
                                SEQUENCE LISTING

<110> CARY, Stephen P. L.
      KRTOLICA, Ana
      LE MOAN, Natacha
      WINGER, Jonathan A.
      LEONG, Kevin G.

<120> MODULATION OF TUMOR IMMUNITY BY
  PROTEIN-MEDIATED O2 DELIVERY

<130> 627042000940

<140> Not Yet Assigned
<141> Concurently Herewith

<150> 62/134,523          
<151> 2015-03-17  

<160> 30

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 555
<212> DNA
<213> Thermoanaerobacter tengcongensis

<400> 1
atgaagggga caatcgtcgg gacatggata aagaccctga gggaccttta cgggaatgat 60
gtggttgatg aatctttaaa aagtgtgggt tgggaaccag atagggtaat tacacctctg 120
gaggatattg atgacgatga ggttaggaga atttttgcta aggtgagtga aaaaactggt 180
aaaaatgtca acgaaatatg gagagaggta ggaaggcaga acataaaaac tttcagcgaa 240
tggtttccct cctattttgc agggagaagg ctagtgaatt ttttaatgat gatggatgag 300
gtacacctac agcttaccaa gatgataaaa ggagccactc ctccaaggct tattgcaaag 360
cctgttgcaa aagatgccat tgaaatggag tacgtttcta aaagaaagat gtacgattac 420
tttttagggc ttatagaggg tagttctaaa tttttcaagg aagaaatttc agtggaagag 480
gtcgaaagag gcgaaaaaga tggcttttca aggctaaaag tcaggataaa atttaaaaac 540
cccgtttttg agtga                                                  555

<210> 2
<211> 184
<212> PRT
<213> Thermoanaerobacter tengcongensis

<400> 2
Met Lys Gly Thr Ile Val Gly Thr Trp Ile Lys Thr Leu Arg Asp Leu
 1               5                  10                  15      
Tyr Gly Asn Asp Val Val Asp Glu Ser Leu Lys Ser Val Gly Trp Glu
            20                  25                  30          
Pro Asp Arg Val Ile Thr Pro Leu Glu Asp Ile Asp Asp Asp Glu Val
        35                  40                  45              
Arg Arg Ile Phe Ala Lys Val Ser Glu Lys Thr Gly Lys Asn Val Asn
    50                  55                  60                  
Glu Ile Trp Arg Glu Val Gly Arg Gln Asn Ile Lys Thr Phe Ser Glu
65                  70                  75                  80  
Trp Phe Pro Ser Tyr Phe Ala Gly Arg Arg Leu Val Asn Phe Leu Met
                85                  90                  95      
Met Met Asp Glu Val His Leu Gln Leu Thr Lys Met Ile Lys Gly Ala
            100                 105                 110         
Thr Pro Pro Arg Leu Ile Ala Lys Pro Val Ala Lys Asp Ala Ile Glu
        115                 120                 125             
Met Glu Tyr Val Ser Lys Arg Lys Met Tyr Asp Tyr Phe Leu Gly Leu
    130                 135                 140                 
Ile Glu Gly Ser Ser Lys Phe Phe Lys Glu Glu Ile Ser Val Glu Glu
145                 150                 155                 160 
Val Glu Arg Gly Glu Lys Asp Gly Phe Ser Arg Leu Lys Val Arg Ile
                165                 170                 175     
Lys Phe Lys Asn Pro Val Phe Glu
            180                 


<210> 3
<211> 81
<212> DNA
<213> Thermoanaerobacter tengcongensis

<400> 3
ggttatattc ctgaagctcc aagagatggg caagcttacg ttcgtaaaga tggcgaatgg 60
gtattacttt ctaccttttt a                                           81

<210> 4
<211> 27
<212> PRT
<213> Thermoanaerobacter tengcongensis

<400> 4
Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys
 1               5                  10                  15      
Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu
            20                  25          


<210> 5
<211> 690
<212> DNA
<213> Thermoanaerobacter tengcongensis

<400> 5
atgaagggga caatcgtcgg gacatggata aagaccctga gggaccttta cgggaatgat 60
gtggttgatg aatctttaaa aagtgtgggt tgggaaccag atagggtaat tacacctctg 120
gaggatattg atgacgatga ggttaggaga atttttgcta aggtgagtga aaaaactggt 180
aaaaatgtca acgaaatatg gagagaggta ggaaggcaga acataaaaac tttcagcgaa 240
tggtttccct cctattttgc agggagaagg ctagtgaatt ttttaatgat gatggatgag 300
gtacacctac agcttaccaa gatgataaaa ggagccactc ctccaaggct tattgcaaag 360
cctgttgcaa aagatgccat tgaaatggag tacgtttcta aaagaaagat gtacgattac 420
tttttagggt ttatagaggg tagttctaaa tttttcaagg aagaaatttc agtggaagag 480
gtcgaaagag gcgaaaaaga tggcttttca aggctaaaag tcaggataaa atttaaaaac 540
cccgtttttg agtataagaa aaatctcgag ggcagcggcg gttatattcc tgaagctcca 600
agagatgggc aggcttacgt tcgtaaagat ggcgaatggg tattactttc taccttttta 660
aggggtagtc accatcacca tcaccattga                                  690

<210> 6
<211> 225
<212> PRT
<213> Thermoanaerobacter tengcongensis

<400> 6
Met Lys Gly Thr Ile Val Gly Thr Trp Ile Lys Thr Leu Arg Asp Leu
 1               5                  10                  15      
Tyr Gly Asn Asp Val Val Asp Glu Ser Leu Lys Ser Val Gly Trp Glu
            20                  25                  30          
Pro Asp Arg Val Ile Thr Pro Leu Glu Asp Ile Asp Asp Asp Glu Val
        35                  40                  45              
Arg Arg Ile Phe Ala Lys Val Ser Glu Lys Thr Gly Lys Asn Val Asn
    50                  55                  60                  
Glu Ile Trp Arg Glu Val Gly Arg Gln Asn Ile Lys Thr Phe Ser Glu
65                  70                  75                  80  
Trp Phe Pro Ser Tyr Phe Ala Gly Arg Arg Leu Val Asn Phe Leu Met
                85                  90                  95      
Met Met Asp Glu Val His Leu Gln Leu Thr Lys Met Ile Lys Gly Ala
            100                 105                 110         
Thr Pro Pro Arg Leu Ile Ala Lys Pro Val Ala Lys Asp Ala Ile Glu
        115                 120                 125             
Met Glu Tyr Val Ser Lys Arg Lys Met Tyr Asp Tyr Phe Leu Gly Phe
    130                 135                 140                 
Ile Glu Gly Lys Phe Phe Lys Glu Glu Ile Glu Glu Val Glu Arg Gly
145                 150                 155                 160 
Glu Lys Asp Gly Phe Ser Arg Leu Lys Val Arg Ile Lys Phe Lys Asn
                165                 170                 175     
Pro Val Phe Glu Tyr Lys Lys Asn Leu Glu Gly Ser Gly Gly Tyr Ile
            180                 185                 190         
Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu
        195                 200                 205             
Trp Val Leu Leu Ser Thr Phe Leu Arg Gly Ser His His His His His
    210                 215                 220                 
His
225 


<210> 7
<211> 663
<212> DNA
<213> Thermoanaerobacter tengcongensis

<400> 7
atgaagggga caatcgtcgg gacatggata aagaccctga gggaccttta cgggaatgat 60
gtggttgatg aatctttaaa aagtgtgggt tgggaaccag atagggtaat tacacctctg 120
gaggatattg atgacgatga ggttaggaga atttttgcta aggtgagtga aaaaactggt 180
aaaaatgtca acgaaatatg gagagaggta ggaaggcaga acataaaaac tttcagcgaa 240
tggtttccct cctattttgc agggagaagg ctagtgaatt ttttaatgat gatggatgag 300
gtacacctac agcttaccaa gatgataaaa ggagccactc ctccaaggct tattgcaaag 360
cctgttgcaa aagatgccat tgaaatggag tacgtttcta aaagaaagat gtacgattac 420
tttttagggt ttatagaggg tagttctaaa tttttcaagg aagaaatttc agtggaagag 480
gtcgaaagag gcgaaaaaga tggcttttca aggctaaaag tcaggataaa atttaaaaac 540
cccgtttttg agtataagaa aaatctcgag ggcagcggcg gttatattcc tgaagctcca 600
agagatgggc aggcttacgt tcgtaaagat ggcgaatggg tattactttc taccttttta 660
tga                                                               663

<210> 8
<211> 167
<212> PRT
<213> Thermoanaerobacter tengcongensis

<400> 8
Met Lys Gly Thr Ile Gly Thr Ile Lys Thr Leu Arg Asp Leu Gly Asn
 1               5                  10                  15      
Asp Asp Glu Leu Lys Gly Glu Asp Arg Ile Thr Leu Glu Asp Ile Asp
            20                  25                  30          
Asp Asp Glu Arg Arg Ile Phe Ala Lys Glu Lys Thr Gly Lys Asn Asn
        35                  40                  45              
Glu Ile Arg Glu Gly Arg Gln Asn Ile Lys Thr Phe Glu Phe Phe Ala
    50                  55                  60                  
Gly Arg Arg Leu Asn Phe Leu Met Met Met Asp Glu His Leu Gln Leu
65                  70                  75                  80  
Thr Lys Met Ile Lys Gly Ala Thr Arg Leu Ile Ala Lys Ala Lys Asp
                85                  90                  95      
Ala Ile Glu Met Glu Lys Arg Lys Met Asp Phe Leu Gly Phe Ile Glu
            100                 105                 110         
Gly Lys Phe Phe Lys Glu Glu Ile Glu Glu Glu Arg Gly Glu Lys Asp
        115                 120                 125             
Gly Phe Arg Leu Lys Arg Ile Lys Phe Lys Asn Phe Glu Lys Lys Asn
    130                 135                 140                 
Leu Glu Gly Gly Gly Ile Glu Ala Arg Asp Gly Gln Ala Arg Lys Asp
145                 150                 155                 160 
Gly Glu Leu Leu Thr Phe Leu
                165         


<210> 9
<211> 564
<212> DNA
<213> Legionella pneumophila

<400> 9
atgatgtcta tgaaaggaat catattcaac gaatttctca attttgtaga aaaaagtgaa 60
tcctacaccc tggtagatca aattattatg gatagtcatt tgaagtccca tggtgcctac 120
acgtctatcg gtacatactc tcccaaagaa ttatttcaat tggttaaagc gcttgctatg 180
aaaaatggca aaccaacatc agtgatttta caagaatatg gtgagtattt gtttgaggtt 240
tttgcaaaaa aatatcctca atttttcagg gaaaaaaagt cggtgtttca atttttggaa 300
gcgcttgaaa cacatattca tttcgaagtg aaaaaattgt atgactatac tgaactaccc 360
cattttgaat gccaatatca cagtcaaaat caaatggaaa tgatttacac ttcttcgcgt 420
cctttggccg attttgcgga aggtttaata aaaggttgta ttaaatatca taaagaaaac 480
atgactattg ttcgtgaaaa tctgcctgca aaaacaggct ttaaggtaag atttgtatta 540
acaaaaggcg atcctgatga gtga                                        564

<210> 10
<211> 187
<212> PRT
<213> Legionella pneumophila

<400> 10
Met Met Ser Met Lys Gly Ile Ile Phe Asn Glu Phe Leu Asn Phe Val
 1               5                  10                  15      
Glu Lys Ser Glu Ser Tyr Thr Leu Val Asp Gln Ile Ile Met Asp Ser
            20                  25                  30          
His Leu Lys Ser His Gly Ala Tyr Thr Ser Ile Gly Thr Tyr Ser Pro
        35                  40                  45              
Lys Glu Leu Phe Gln Leu Val Lys Ala Leu Ala Met Lys Asn Gly Lys
    50                  55                  60                  
Pro Thr Ser Val Ile Leu Gln Glu Tyr Gly Glu Tyr Leu Phe Glu Val
65                  70                  75                  80  
Phe Ala Lys Lys Tyr Pro Gln Phe Phe Arg Glu Lys Lys Ser Val Phe
                85                  90                  95      
Gln Phe Leu Glu Ala Leu Glu Thr His Ile His Phe Glu Val Lys Lys
            100                 105                 110         
Leu Tyr Asp Tyr Thr Glu Leu Pro His Phe Glu Cys Gln Tyr His Ser
        115                 120                 125             
Gln Asn Gln Met Glu Met Ile Tyr Thr Ser Ser Arg Pro Leu Ala Asp
    130                 135                 140                 
Phe Ala Glu Gly Leu Ile Lys Gly Cys Ile Lys Tyr His Lys Glu Asn
145                 150                 155                 160 
Met Thr Ile Val Arg Glu Asn Leu Pro Ala Lys Thr Gly Phe Lys Val
                165                 170                 175     
Arg Phe Val Leu Thr Lys Gly Asp Pro Asp Glu
            180                 185         


<210> 11
<211> 543
<212> DNA
<213> Legionella pneumophila

<400> 11
atgaaaggta tcgtttttac ctccttaaat gacatgatta tagaacaatt tggcatagaa 60
acctgggacc aactcgtatc ctcactagac cttccaagtg gtggaagtta tacagcaggc 120
ggcacttact cggatacaga atttcagcaa ttgattaagg ccattgcgaa gaggaccaat 180
cagcacgctt ctgttttttt agaggccttt ggtgaataca tgtttcctat cttatcgagt 240
aagtgcgcaa tttttttaaa aaaggacatg acattaaaag aatttttaaa aagcattgat 300
ggaacaattc atgtggaagt agaaaagtta tacccagatg aaacattacc taccattagc 360
tatgaagagc ctgctgcaaa ccaattggtt atggtgtatc gatcgcatag aagactctgt 420
cattttgcaa tggggctcat ccagggagca gcgcaacatt ttaaaaagaa aattaccatt 480
aagcagactc actgcatgtt aaaaaaagat gatcattgtc gtttggagat tacctttgag 540
tga                                                               543

<210> 12
<211> 180
<212> PRT
<213> Legionella pneumophila

<400> 12
Met Lys Gly Ile Val Phe Thr Ser Leu Asn Asp Met Ile Ile Glu Gln
 1               5                  10                  15      
Phe Gly Ile Glu Thr Trp Asp Gln Leu Val Ser Ser Leu Asp Leu Pro
            20                  25                  30          
Ser Gly Gly Ser Tyr Thr Ala Gly Gly Thr Tyr Ser Asp Thr Glu Phe
        35                  40                  45              
Gln Gln Leu Ile Lys Ala Ile Ala Lys Arg Thr Asn Gln His Ala Ser
    50                  55                  60                  
Val Phe Leu Glu Ala Phe Gly Glu Tyr Met Phe Pro Ile Leu Ser Ser
65                  70                  75                  80  
Lys Cys Ala Ile Phe Leu Lys Lys Asp Met Thr Leu Lys Glu Phe Leu
                85                  90                  95      
Lys Ser Ile Asp Gly Thr Ile His Val Glu Val Glu Lys Leu Tyr Pro
            100                 105                 110         
Asp Glu Thr Leu Pro Thr Ile Ser Tyr Glu Glu Pro Ala Ala Asn Gln
        115                 120                 125             
Leu Val Met Val Tyr Arg Ser His Arg Arg Leu Cys His Phe Ala Met
    130                 135                 140                 
Gly Leu Ile Gln Gly Ala Ala Gln His Phe Lys Lys Lys Ile Thr Ile
145                 150                 155                 160 
Lys Gln Thr His Cys Met Leu Lys Lys Asp Asp His Cys Arg Leu Glu
                165                 170                 175     
Ile Thr Phe Glu
            180 


<210> 13
<211> 1158
<212> DNA
<213> Homo sapiens

<400> 13
atgtacggat ttgtgaatca cgccctggag ttgctggtga tccgcaatta cggccccgag 60
gtgtgggaag acatcaaaaa agaggcacag ttagatgaag aaggacagtt tcttgtcaga 120
ataatatatg atgactccaa aacttatgat ttggttgctg ctgcaagcaa agtcctcaat 180
ctcaatgctg gagaaatcct ccaaatgttt gggaagatgt ttttcgtctt ttgccaagaa 240
tctggttatg atacaatctt gcgtgtcctg ggctctaatg tcagagaatt tctacagaac 300
cttgatgctc tgcacgacca ccttgctacc atctacccag gaatgcgtgc accttccttt 360
aggtgcactg atgcagaaaa gggcaaagga ctcattttgc actactactc agagagagaa 420
ggacttcagg atattgtcat tggaatcatc aaaacagtgg cacaacaaat ccatggcact 480
gaaatagaca tgaaggttat tcagcaaaga aatgaagaat gtgatcatac tcaattttta 540
attgaagaaa aagagtcaaa agaagaggat ttttatgaag atcttgacag atttgaagaa 600
aatggtaccc aggaatcacg catcagccca tatacattct gcaaagcttt tccttttcat 660
ataatatttg accgggacct agtggtcact cagtgtggca atgctatata cagagttctc 720
ccccagctcc agcctgggaa ttgcagcctt ctgtctgtct tctcgctggt tcgtcctcat 780
attgatatta gtttccatgg gatcctttct cacatcaata ctgtttttgt attgagaagc 840
aaggaaggat tgttggatgt ggagaaatta gaatgtgagg atgaactgac tgggactgag 900
atcagctgct tacgtctcaa gggtcaaatg atctacttac ctgaagcaga tagcatactt 960
tttctatgtt caccaagtgt catgaacctg gacgatttga caaggagagg gctgtatcta 1020
agtgacatcc ctctgcatga tgccacgcgc gatcttgttc ttttgggaga acaatttaga 1080
gaggaataca aactcaccca agaactggaa atcctcactg acaggctaca gctcacgtta 1140
agagccctgg aagattga                                               1158

<210> 14
<211> 385
<212> PRT
<213> Homo sapiens

<400> 14
Met Tyr Gly Phe Val Asn His Ala Leu Glu Leu Leu Val Ile Arg Asn
 1               5                  10                  15      
Tyr Gly Pro Glu Val Trp Glu Asp Ile Lys Lys Glu Ala Gln Leu Asp
            20                  25                  30          
Glu Glu Gly Gln Phe Leu Val Arg Ile Ile Tyr Asp Asp Ser Lys Thr
        35                  40                  45              
Tyr Asp Leu Val Ala Ala Ala Ser Lys Val Leu Asn Leu Asn Ala Gly
    50                  55                  60                  
Glu Ile Leu Gln Met Phe Gly Lys Met Phe Phe Val Phe Cys Gln Glu
65                  70                  75                  80  
Ser Gly Tyr Asp Thr Ile Leu Arg Val Leu Gly Ser Asn Val Arg Glu
                85                  90                  95      
Phe Leu Gln Asn Leu Asp Ala Leu His Asp His Leu Ala Thr Ile Tyr
            100                 105                 110         
Pro Gly Met Arg Ala Pro Ser Phe Arg Cys Thr Asp Ala Glu Lys Gly
        115                 120                 125             
Lys Gly Leu Ile Leu His Tyr Tyr Ser Glu Arg Glu Gly Leu Gln Asp
    130                 135                 140                 
Ile Val Ile Gly Ile Ile Lys Thr Val Ala Gln Gln Ile His Gly Thr
145                 150                 155                 160 
Glu Ile Asp Met Lys Val Ile Gln Gln Arg Asn Glu Glu Cys Asp His
                165                 170                 175     
Thr Gln Phe Leu Ile Glu Glu Lys Glu Ser Lys Glu Glu Asp Phe Tyr
            180                 185                 190         
Glu Asp Leu Asp Arg Phe Glu Glu Asn Gly Thr Gln Glu Ser Arg Ile
        195                 200                 205             
Ser Pro Tyr Thr Phe Cys Lys Ala Phe Pro Phe His Ile Ile Phe Asp
    210                 215                 220                 
Arg Asp Leu Val Val Thr Gln Cys Gly Asn Ala Ile Tyr Arg Val Leu
225                 230                 235                 240 
Pro Gln Leu Gln Pro Gly Asn Cys Ser Leu Leu Ser Val Phe Ser Leu
                245                 250                 255     
Val Arg Pro His Ile Asp Ile Ser Phe His Gly Ile Leu Ser His Ile
            260                 265                 270         
Asn Thr Val Phe Val Leu Arg Ser Lys Glu Gly Leu Leu Asp Val Glu
        275                 280                 285             
Lys Leu Glu Cys Glu Asp Glu Leu Thr Gly Thr Glu Ile Ser Cys Leu
    290                 295                 300                 
Arg Leu Lys Gly Gln Met Ile Tyr Leu Pro Glu Ala Asp Ser Ile Leu
305                 310                 315                 320 
Phe Leu Cys Ser Pro Ser Val Met Asn Leu Asp Asp Leu Thr Arg Arg
                325                 330                 335     
Gly Leu Tyr Leu Ser Asp Ile Pro Leu His Asp Ala Thr Arg Asp Leu
            340                 345                 350         
Val Leu Leu Gly Glu Gln Phe Arg Glu Glu Tyr Lys Leu Thr Gln Glu
        355                 360                 365             
Leu Glu Ile Leu Thr Asp Arg Leu Gln Leu Thr Leu Arg Ala Leu Glu
    370                 375                 380                 
Asp
385 


<210> 15
<211> 651
<212> DNA
<213> Homo sapiens

<400> 15
atgtatggat tcatcaacac ctgcctgcag tctcttgtga cagagaaatt tggtgaggag 60
acatgggaga agctgaaggc tcctgcagaa gtgcaagatg tcttcatgac ctacaccgtg 120
tatgatgaca tcatcaccat taagctcatc caagaagcct gcaaggttct ggatgtgtcc 180
atggaagcca ttctgaagct ctttggcgaa tacttcttta agttctgtaa gatgtctggc 240
tatgacagga tgctgcggac acttggagga aatctcaccg agtttattga aaacctagat 300
gcactccaca gttacctggc actgtcctat caggaaatga acgcaccatc ctttcgagtg 360
gaggaaggag ctgacggggc gatgcttctc cactactact cagacagaca tggtctgtgt 420
cacattgtac caggtatcat tgaagctgtg gccaaggact tctttgacac tgatgtggcc 480
atgagtatcc tggatatgaa cgaagaggtg gaaaggacag ggaagaaaga acatgttgtg 540
tttctggtcg tgcagaaggc tcacagacag ataagaggag caaaggcaag ccggccacaa 600
ggcagtgagg acagccaggc agaccaggag gctctccagg gaacactcct t          651

<210> 16
<211> 217
<212> PRT
<213> Homo sapiens

<400> 16
Met Tyr Gly Phe Ile Asn Thr Cys Leu Gln Ser Leu Val Thr Glu Lys
 1               5                  10                  15      
Phe Gly Glu Glu Thr Trp Glu Lys Leu Lys Ala Pro Ala Glu Val Gln
            20                  25                  30          
Asp Val Phe Met Thr Tyr Thr Val Tyr Asp Asp Ile Ile Thr Ile Lys
        35                  40                  45              
Leu Ile Gln Glu Ala Cys Lys Val Leu Asp Val Ser Met Glu Ala Ile
    50                  55                  60                  
Leu Lys Leu Phe Gly Glu Tyr Phe Phe Lys Phe Cys Lys Met Ser Gly
65                  70                  75                  80  
Tyr Asp Arg Met Leu Arg Thr Leu Gly Gly Asn Leu Thr Glu Phe Ile
                85                  90                  95      
Glu Asn Leu Asp Ala Leu His Ser Tyr Leu Ala Leu Ser Tyr Gln Glu
            100                 105                 110         
Met Asn Ala Pro Ser Phe Arg Val Glu Glu Gly Ala Asp Gly Ala Met
        115                 120                 125             
Leu Leu His Tyr Tyr Ser Asp Arg His Gly Leu Cys His Ile Val Pro
    130                 135                 140                 
Gly Ile Ile Glu Ala Val Ala Lys Asp Phe Phe Asp Thr Asp Val Ala
145                 150                 155                 160 
Met Ser Ile Leu Asp Met Asn Glu Glu Val Glu Arg Thr Gly Lys Lys
                165                 170                 175     
Glu His Val Val Phe Leu Val Val Gln Lys Ala His Arg Gln Ile Arg
            180                 185                 190         
Gly Ala Lys Ala Ser Arg Pro Gln Gly Ser Glu Asp Ser Gln Ala Asp
        195                 200                 205             
Gln Glu Ala Leu Gln Gly Thr Leu Leu
    210                 215         


<210> 17
<211> 1158
<212> DNA
<213> Rattus norvegicus

<400> 17
atgtacggtt ttgtgaacca tgccctggag ctgctggtga tccgcaatta cggtcccgag 60
gtgtgggaag acatcaaaaa agaggcgcag ctggatgaag aaggccagtt tcttgtgaga 120
ataatctacg atgattccaa aacctatgac ttggtggctg ctgcgagcaa agtcctcaac 180
ctcaatgctg gtgaaatcct gcagatgttt gggaagatgt ttttcgtctt ctgtcaagag 240
tctggctatg ataccatctt gcgtgtcctg ggatctaatg tcagggagtt tttgcagaac 300
ctcgacgccc tgcacgacca cctcgccacc atctacccag ggatgcgcgc accttccttc 360
cggtgcaccg atgcagaaaa aggcaaaggg ctcattctgc actactactc ggaaagagag 420
gggcttcagg acattgtgat cgggattatc aagactgtag ctcaacagat ccatggcact 480
gagatagaca tgaaggttat tcagcaaaga agtgaagaat gtgatcatac ccaattttta 540
attgaagaaa aagaatcaaa agaagaggat ttttatgaag atctggacag gtttgaagag 600
aacggtaccc aggactcccg tatcagcccg tacaccttct gcaaagcgtt tccttttcac 660
atcatatttg accgggacct agtagtcacg cagtgtggaa atgctatcta cagagtgctc 720
ccccagctcc agcctgggaa gtgcagcctt ctgtctgtct tctctctggt ccgccctcat 780
attgacatca gtttccacgg gattctttca cacatcaata ccgtctttgt actgagaagc 840
aaggaagggt tgctggatgt tgagaaactt gaatgtgagg atgaactgac tggggcagag 900
attagctgcc tccgtctcaa aggccaaatg atctatttac cggaagcaga tagcatcctc 960
ttcctctgtt caccaagtgt gatgaacttg gatgacctaa caagaagagg cctgtacctg 1020
agtgacatcc ctctccatga tgctacacga gacctggtcc ttttgggaga acagttccgg 1080
gaggagtaca aactgacaca agagctggaa atcctcacag acaggctgca gctcacactg 1140
agggctttgg aggattga                                               1158

<210> 18
<211> 385
<212> PRT
<213> Rattus norvegicus

<400> 18
Met Tyr Gly Phe Val Asn His Ala Leu Glu Leu Leu Val Ile Arg Asn
 1               5                  10                  15      
Tyr Gly Pro Glu Val Trp Glu Asp Ile Lys Lys Glu Ala Gln Leu Asp
            20                  25                  30          
Glu Glu Gly Gln Phe Leu Val Arg Ile Ile Tyr Asp Asp Ser Lys Thr
        35                  40                  45              
Tyr Asp Leu Val Ala Ala Ala Ser Lys Val Leu Asn Leu Asn Ala Gly
    50                  55                  60                  
Glu Ile Leu Gln Met Phe Gly Lys Met Phe Phe Val Phe Cys Gln Glu
65                  70                  75                  80  
Ser Gly Tyr Asp Thr Ile Leu Arg Val Leu Gly Ser Asn Val Arg Glu
                85                  90                  95      
Phe Leu Gln Asn Leu Asp Ala Leu His Asp His Leu Ala Thr Ile Tyr
            100                 105                 110         
Pro Gly Met Arg Ala Pro Ser Phe Arg Cys Thr Asp Ala Glu Lys Gly
        115                 120                 125             
Lys Gly Leu Ile Leu His Tyr Tyr Ser Glu Arg Glu Gly Leu Gln Asp
    130                 135                 140                 
Ile Val Ile Gly Ile Ile Lys Thr Val Ala Gln Gln Ile His Gly Thr
145                 150                 155                 160 
Glu Ile Asp Met Lys Val Ile Gln Gln Arg Ser Glu Glu Cys Asp His
                165                 170                 175     
Thr Gln Phe Leu Ile Glu Glu Lys Glu Ser Lys Glu Glu Asp Phe Tyr
            180                 185                 190         
Glu Asp Leu Asp Arg Phe Glu Glu Asn Gly Thr Gln Asp Ser Arg Ile
        195                 200                 205             
Ser Pro Tyr Thr Phe Cys Lys Ala Phe Pro Phe His Ile Ile Phe Asp
    210                 215                 220                 
Arg Asp Leu Val Val Thr Gln Cys Gly Asn Ala Ile Tyr Arg Val Leu
225                 230                 235                 240 
Pro Gln Leu Gln Pro Gly Lys Cys Ser Leu Leu Ser Val Phe Ser Leu
                245                 250                 255     
Val Arg Pro His Ile Asp Ile Ser Phe His Gly Ile Leu Ser His Ile
            260                 265                 270         
Asn Thr Val Phe Val Leu Arg Ser Lys Glu Gly Leu Leu Asp Val Glu
        275                 280                 285             
Lys Leu Glu Cys Glu Asp Glu Leu Thr Gly Ala Glu Ile Ser Cys Leu
    290                 295                 300                 
Arg Leu Lys Gly Gln Met Ile Tyr Leu Pro Glu Ala Asp Ser Ile Leu
305                 310                 315                 320 
Phe Leu Cys Ser Pro Ser Val Met Asn Leu Asp Asp Leu Thr Arg Arg
                325                 330                 335     
Gly Leu Tyr Leu Ser Asp Ile Pro Leu His Asp Ala Thr Arg Asp Leu
            340                 345                 350         
Val Leu Leu Gly Glu Gln Phe Arg Glu Glu Tyr Lys Leu Thr Gln Glu
        355                 360                 365             
Leu Glu Ile Leu Thr Asp Arg Leu Gln Leu Thr Leu Arg Ala Leu Glu
    370                 375                 380                 
Asp
385 


<210> 19
<211> 1158
<212> DNA
<213> Rattus norvegicus

<400> 19
atgtacggtt ttgtgaacca tgccctggag ctgctggtga tccgcaatta cggtcccgag 60
gtgtgggaag acatcaaaaa agaggcgcag ctggatgaag aaggccagtt tcttgtgaga 120
ataatctacg atgattccaa aacctatgac ttggtggctg ctgcgagcaa agtcctcaac 180
ctcaatgctg gtgaaatcct gcagatgttt gggaagatgt ttttcgtctt ctgtcaagag 240
tctggctatg ataccatctt gcgtgtcctg ggatctaatg tcagggagtt tttgcagaac 300
ctcgacgccc tgcacgacca cctcgccacc atctacccag ggatgcgcgc accttccttc 360
cggtgcaccg atgcagaaaa aggcaaaggg ctcattctgc actactactc ggaaagagag 420
gggcttcagg acattgtgat cgggattatc aagactgtag ctcaacagat ccatggcact 480
gagatagaca tgaaggttat tcagcaaaga agtgaagaat gtgatcatac ccaattttta 540
attgaagaaa aagaatcaaa agaagaggat ttttatgaag atctggacag gtttgaagag 600
aacggtaccc aggactcccg tatcagcccg tacaccttct gcaaagcgtt tccttttcac 660
atcatatttg accgggacct agtagtcacg cagtgtggaa atgctatcta cagagtgctc 720
ccccagctcc agcctgggaa gtgcagcctt ctgtctgtct tctctctggt ccgccctcat 780
attgacatca gtttccacgg gattctttca cacatcaata ccgtctttgt actgagaagc 840
aaggaagggt tgctggatgt tgagaaactt gaatgtgagg atgaactgac tggggcagag 900
attagctgcc tccgtctcaa aggccaaatg atctatttac cggaagcaga tagcatcctc 960
ttcctctgtt caccaagtgt gatgaacttg gatgacctaa caagaagagg cctgtacctg 1020
agtgacatcc ctctccatga tgctacacga gacctggtcc ttttgggaga acagttccgg 1080
gaggagtaca aactgacaca agagctggaa atcctcacag acaggctgca gctcacactg 1140
agggctttgg aggattga                                               1158

<210> 20
<211> 385
<212> PRT
<213> Rattus norvegicus

<400> 20
Met Tyr Gly Phe Val Asn His Ala Leu Glu Leu Leu Val Ile Arg Asn
 1               5                  10                  15      
Tyr Gly Pro Glu Val Trp Glu Asp Ile Lys Lys Glu Ala Gln Leu Asp
            20                  25                  30          
Glu Glu Gly Gln Phe Leu Val Arg Ile Ile Tyr Asp Asp Ser Lys Thr
        35                  40                  45              
Tyr Asp Leu Val Ala Ala Ala Ser Lys Val Leu Asn Leu Asn Ala Gly
    50                  55                  60                  
Glu Ile Leu Gln Met Phe Gly Lys Met Phe Phe Val Phe Cys Gln Glu
65                  70                  75                  80  
Ser Gly Tyr Asp Thr Ile Leu Arg Val Leu Gly Ser Asn Val Arg Glu
                85                  90                  95      
Phe Leu Gln Asn Leu Asp Ala Leu His Asp His Leu Ala Thr Ile Tyr
            100                 105                 110         
Pro Gly Met Arg Ala Pro Ser Phe Arg Cys Thr Asp Ala Glu Lys Gly
        115                 120                 125             
Lys Gly Leu Ile Leu His Tyr Tyr Ser Glu Arg Glu Gly Leu Gln Asp
    130                 135                 140                 
Ile Val Ile Gly Ile Ile Lys Thr Val Ala Gln Gln Ile His Gly Thr
145                 150                 155                 160 
Glu Ile Asp Met Lys Val Ile Gln Gln Arg Ser Glu Glu Cys Asp His
                165                 170                 175     
Thr Gln Phe Leu Ile Glu Glu Lys Glu Ser Lys Glu Glu Asp Phe Tyr
            180                 185                 190         
Glu Asp Leu Asp Arg Phe Glu Glu Asn Gly Thr Gln Asp Ser Arg Ile
        195                 200                 205             
Ser Pro Tyr Thr Phe Cys Lys Ala Phe Pro Phe His Ile Ile Phe Asp
    210                 215                 220                 
Arg Asp Leu Val Val Thr Gln Cys Gly Asn Ala Ile Tyr Arg Val Leu
225                 230                 235                 240 
Pro Gln Leu Gln Pro Gly Lys Cys Ser Leu Leu Ser Val Phe Ser Leu
                245                 250                 255     
Val Arg Pro His Ile Asp Ile Ser Phe His Gly Ile Leu Ser His Ile
            260                 265                 270         
Asn Thr Val Phe Val Leu Arg Ser Lys Glu Gly Leu Leu Asp Val Glu
        275                 280                 285             
Lys Leu Glu Cys Glu Asp Glu Leu Thr Gly Ala Glu Ile Ser Cys Leu
    290                 295                 300                 
Arg Leu Lys Gly Gln Met Ile Tyr Leu Pro Glu Ala Asp Ser Ile Leu
305                 310                 315                 320 
Phe Leu Cys Ser Pro Ser Val Met Asn Leu Asp Asp Leu Thr Arg Arg
                325                 330                 335     
Gly Leu Tyr Leu Ser Asp Ile Pro Leu His Asp Ala Thr Arg Asp Leu
            340                 345                 350         
Val Leu Leu Gly Glu Gln Phe Arg Glu Glu Tyr Lys Leu Thr Gln Glu
        355                 360                 365             
Leu Glu Ile Leu Thr Asp Arg Leu Gln Leu Thr Leu Arg Ala Leu Glu
    370                 375                 380                 
Asp
385 


<210> 21
<211> 2229
<212> DNA
<213> Rattus norvegicus

<400> 21
atgtatggat tcatcaacac ctgcctgcag tctcttgtga cagagaaatt tggtgaggag 60
acatgggaga agctgaaggc tcctgcagaa gtgcaagatg tcttcatgac ctacaccgtg 120
tatgatgaca tcatcaccat taagctcatc caagaagcct gcaaggttct ggatgtgtcc 180
atggaagcca ttctgaagct ctttggcgaa tacttcttta agttctgtaa gatgtctggc 240
tatgacagga tgctgcggac acttggagga aatctcaccg agtttattga aaacctagat 300
gcactccaca gttacctggc actgtcctat caggaaatga acgcaccatc ctttcgagtg 360
gaggaaggag ctgacggggc gatgcttctc cactactact cagacagaca tggtctgtgt 420
cacattgtac caggtatcat tgaagctgtg gccaaggact tctttgacac tgatgtggcc 480
atgagtatcc tggatatgaa cgaagaggtg gaaaggacag ggaagaaaga acatgttgtg 540
tttctggtcg tgcagaaggc tcacagacag ataagaggag caaaggcaag ccggccacaa 600
ggcagtgagg acagccaggc agaccaggag gctctccagg gaacactcct tcggatgaag 660
gagagatatt taaacatccc tgtttgccct ggggagaaat ctcactcaac tgctgtgagg 720
gcatcggtcc tttttggaaa agggcccctc agggacacct tccagcccgt ctatcctgag 780
agactatggg tcgaagagga ggtgttctgt gatgcttttc ctttccacat tgtctttgat 840
gaagcactaa gggtcaagca agctggagtg aatattcaga agtatgtccc tggaatctta 900
acccagaagt ttgcactaga tgagtatttt tccatcatcc accctcaagt tactttcaac 960
atctccagca tctgcaagtt cattaacagt cagtttgtct tgaagacaag aaaagaaatg 1020
atgcccaaag caaggaagag ccagccgatg ctcaaactcc ggggtcagat gatctggatg 1080
gagtctctga ggtgcatgat cttcatgtgt tccccaaacg tccgcagcct gcaagagctg 1140
gaagagagca agatgcatct ttctgatatc gctccgcacg acacgaccag ggatctcatc 1200
ctcctcaacc agcagaggct ggcagagatg gagctgtcct gccaactgga aaagaagaag 1260
gaggagttgc gtgtcctttc caatcacctg gccatcgaga agaagaagac agagaccttg 1320
ctgtatgcca tgctgcctga acatgtggcc aaccaactca aggagggcag aaaggtggct 1380
gcaggagaat ttgaaacatg tacaatcctt ttcagcgatg ttgtgacatt taccaacatc 1440
tgtgcagcct gtgaacctat ccaaatcgtg aacatgctga attcaatgta ctccaagttt 1500
gacaggttaa ccagtgtcca tgatgtctac aaagtagaaa caatagggga tgcttacatg 1560
gtggtgggtg gagtaccagt acccgttgaa agccatgctc aaagagtcgc caattttgct 1620
ctggggatga gaatttctgc aaaagaagtg atgaatcctg tcactgggga acctatccag 1680
atcagagtgg gaatccacac tggaccagtc ttagcaggtg ttgtgggaga caagatgcct 1740
cggtactgct tgtttggtga cactgtaaac acagcctcta ggatggaaag tcacgggctt 1800
cccagcaaag tgcatctgag ccccacagcc cacagagccc tgaaaaacaa agggtttgaa 1860
attgtcagga gaggcgagat cgaagtgaag gggaaaggaa agatgaccac atactttctg 1920
atccagaacc tgaatgccac cgaggatgag ataatggggc gaccttcagc ccccgctgat 1980
gggaaggaag tatgtactcc cggaaaccaa gtcaggaagt cccctgctgt cccgaggaac 2040
acagaccatc agcaacaagt ctacaaagga gacccagcag acgcttctaa tgaagtcaca 2100
cttgctggga gcccagtggc agggcgaaac tccacagatg cagtcaataa ccagccatca 2160
ccagatgaga ccaagacaag tgtcgttgct agtggccctg tgctgtctgc tttctgtgtt 2220
gtgctgtga                                                         2229

<210> 22
<211> 742
<212> PRT
<213> Rattus norvegicus

<400> 22
Met Tyr Gly Phe Ile Asn Thr Cys Leu Gln Ser Leu Val Thr Glu Lys
 1               5                  10                  15      
Phe Gly Glu Glu Thr Trp Glu Lys Leu Lys Ala Pro Ala Glu Val Gln
            20                  25                  30          
Asp Val Phe Met Thr Tyr Thr Val Tyr Asp Asp Ile Ile Thr Ile Lys
        35                  40                  45              
Leu Ile Gln Glu Ala Cys Lys Val Leu Asp Val Ser Met Glu Ala Ile
    50                  55                  60                  
Leu Lys Leu Phe Gly Glu Tyr Phe Phe Lys Phe Cys Lys Met Ser Gly
65                  70                  75                  80  
Tyr Asp Arg Met Leu Arg Thr Leu Gly Gly Asn Leu Thr Glu Phe Ile
                85                  90                  95      
Glu Asn Leu Asp Ala Leu His Ser Tyr Leu Ala Leu Ser Tyr Gln Glu
            100                 105                 110         
Met Asn Ala Pro Ser Phe Arg Val Glu Glu Gly Ala Asp Gly Ala Met
        115                 120                 125             
Leu Leu His Tyr Tyr Ser Asp Arg His Gly Leu Cys His Ile Val Pro
    130                 135                 140                 
Gly Ile Ile Glu Ala Val Ala Lys Asp Phe Phe Asp Thr Asp Val Ala
145                 150                 155                 160 
Met Ser Ile Leu Asp Met Asn Glu Glu Val Glu Arg Thr Gly Lys Lys
                165                 170                 175     
Glu His Val Val Phe Leu Val Val Gln Lys Ala His Arg Gln Ile Arg
            180                 185                 190         
Gly Ala Lys Ala Ser Arg Pro Gln Gly Ser Glu Asp Ser Gln Ala Asp
        195                 200                 205             
Gln Glu Ala Leu Gln Gly Thr Leu Leu Arg Met Lys Glu Arg Tyr Leu
    210                 215                 220                 
Asn Ile Pro Val Cys Pro Gly Glu Lys Ser His Ser Thr Ala Val Arg
225                 230                 235                 240 
Ala Ser Val Leu Phe Gly Lys Gly Pro Leu Arg Asp Thr Phe Gln Pro
                245                 250                 255     
Val Tyr Pro Glu Arg Leu Trp Val Glu Glu Glu Val Phe Cys Asp Ala
            260                 265                 270         
Phe Pro Phe His Ile Val Phe Asp Glu Ala Leu Arg Val Lys Gln Ala
        275                 280                 285             
Gly Val Asn Ile Gln Lys Tyr Val Pro Gly Ile Leu Thr Gln Lys Phe
    290                 295                 300                 
Ala Leu Asp Glu Tyr Phe Ser Ile Ile His Pro Gln Val Thr Phe Asn
305                 310                 315                 320 
Ile Ser Ser Ile Cys Lys Phe Ile Asn Ser Gln Phe Val Leu Lys Thr
                325                 330                 335     
Arg Lys Glu Met Met Pro Lys Ala Arg Lys Ser Gln Pro Met Leu Lys
            340                 345                 350         
Leu Arg Gly Gln Met Ile Trp Met Glu Ser Leu Arg Cys Met Ile Phe
        355                 360                 365             
Met Cys Ser Pro Asn Val Arg Ser Leu Gln Glu Leu Glu Glu Ser Lys
    370                 375                 380                 
Met His Leu Ser Asp Ile Ala Pro His Asp Thr Thr Arg Asp Leu Ile
385                 390                 395                 400 
Leu Leu Asn Gln Gln Arg Leu Ala Glu Met Glu Leu Ser Cys Gln Leu
                405                 410                 415     
Glu Lys Lys Lys Glu Glu Leu Arg Val Leu Ser Asn His Leu Ala Ile
            420                 425                 430         
Glu Lys Lys Lys Thr Glu Thr Leu Leu Tyr Ala Met Leu Pro Glu His
        435                 440                 445             
Val Ala Asn Gln Leu Lys Glu Gly Arg Lys Val Ala Ala Gly Glu Phe
    450                 455                 460                 
Glu Thr Cys Thr Ile Leu Phe Ser Asp Val Val Thr Phe Thr Asn Ile
465                 470                 475                 480 
Cys Ala Ala Cys Glu Pro Ile Gln Ile Val Asn Met Leu Asn Ser Met
                485                 490                 495     
Tyr Ser Lys Phe Asp Arg Leu Thr Ser Val His Asp Val Tyr Lys Val
            500                 505                 510         
Glu Thr Ile Gly Asp Ala Tyr Met Val Val Gly Gly Val Pro Val Pro
        515                 520                 525             
Val Glu Ser His Ala Gln Arg Val Ala Asn Phe Ala Leu Gly Met Arg
    530                 535                 540                 
Ile Ser Ala Lys Glu Val Met Asn Pro Val Thr Gly Glu Pro Ile Gln
545                 550                 555                 560 
Ile Arg Val Gly Ile His Thr Gly Pro Val Leu Ala Gly Val Val Gly
                565                 570                 575     
Asp Lys Met Pro Arg Tyr Cys Leu Phe Gly Asp Thr Val Asn Thr Ala
            580                 585                 590         
Ser Arg Met Glu Ser His Gly Leu Pro Ser Lys Val His Leu Ser Pro
        595                 600                 605             
Thr Ala His Arg Ala Leu Lys Asn Lys Gly Phe Glu Ile Val Arg Arg
    610                 615                 620                 
Gly Glu Ile Glu Val Lys Gly Lys Gly Lys Met Thr Thr Tyr Phe Leu
625                 630                 635                 640 
Ile Gln Asn Leu Asn Ala Thr Glu Asp Glu Ile Met Gly Arg Pro Ser
                645                 650                 655     
Ala Pro Ala Asp Gly Lys Glu Val Cys Thr Pro Gly Asn Gln Val Arg
            660                 665                 670         
Lys Ser Pro Ala Val Pro Arg Asn Thr Asp His Gln Gln Gln Val Tyr
        675                 680                 685             
Lys Gly Asp Pro Ala Asp Ala Ser Asn Glu Val Thr Leu Ala Gly Ser
    690                 695                 700                 
Pro Val Ala Gly Arg Asn Ser Thr Asp Ala Val Asn Asn Gln Pro Ser
705                 710                 715                 720 
Pro Asp Glu Thr Lys Thr Ser Val Val Ala Ser Gly Pro Val Leu Ser
                725                 730                 735     
Ala Phe Cys Val Val Leu
            740         


<210> 23
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Cys Ala Ala Thr Cys Gly Ala Gly Ala Cys Cys Cys Thr Gly Gly Thr
 1               5                  10                  15      
Gly Gly Ala
            


<210> 24
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Gly Cys Ala Cys Ala Cys Ala Cys Thr Cys Cys Ala Gly Gly Cys Cys
 1               5                  10                  15      
Cys Thr
        


<210> 25
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Cys Ala Ala Cys Cys Ala Gly Ala Cys Ala Thr Gly Gly Gly Thr Cys
 1               5                  10                  15      
Cys Ala Cys
            


<210> 26
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Gly Thr Thr Ala Ala Cys Gly Ala Ala Ala Ala Gly Gly Cys Cys Cys
 1               5                  10                  15      
Ala Cys Ala Gly Ala
            20      


<210> 27
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Gly Thr Thr Gly Thr Gly Gly Ala Thr Cys Cys Ala Gly Thr Cys Ala
 1               5                  10                  15      
Cys Cys Thr Cys Thr
            20      


<210> 28
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Gly Ala Thr Thr Cys Thr Cys Ala Gly Thr Gly Thr Gly Cys Thr Gly
 1               5                  10                  15      
Gly Thr Cys Ala Cys
            20      


<210> 29
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Cys Ala Ala Gly Gly Ala Gly Gly Ala Ala Gly Cys Thr Thr Ala Thr
 1               5                  10                  15      
Cys Thr Ala Thr Gly Ala Ala
            20              


<210> 30
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Ala Thr Thr Thr Gly Ala Cys Gly Ala Ala Gly Gly Cys Gly Ala Ala
 1               5                  10                  15      
Gly Ala Ala Gly Cys Thr
            20          

