                         SEQUENCE LISTING

<110>  Arrowhead Research Corporation
       Kanner, Steven B
       Lewis, David L
       Wakefield, Darren H
       Almeida, Lauren J
 
<120>  Compositions and Methods for Inhibiting Gene Expression 
       of Factor XII 

<130>  30626-WO1

<150>  62134186
<151>  2015-03-17

<160>  2322

<210>  1
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1
tggugguagc acaccagggt t             21


<210>  2
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  2
tgggugguag cacaccaggt t             21


<210>  3
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  3
tgggguggua gcacaccagt t             21


<210>  4
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  4
tcacuuucuu gggcuccaat t             21


<210>  5
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  5
tucacuuucu ugggcuccat t             21


<210>  6
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  6
tuucacuuuc uugggcucct t             21


<210>  7
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  7
tuuucacuuu cuugggcuct t             21


<210>  8
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  8
tcuuucacuu ucuugggcut t             21


<210>  9
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  9
tucuuucacu uucuugggct t             21


<210>  10
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  10
tgucuuucac uuucuugggt t             21


<210>  11
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  11
tggucuuuca cuuucuuggt t             21


<210>  12
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  12
tuggucuuuc acuuucuugt t             21


<210>  13
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  13
tagcugaggc ucaaagcact t             21


<210>  14
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  14
taagcugagg cucaaagcat t             21


<210>  15
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  15
tgaagcugag gcucaaagct t             21


<210>  16
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  16
tgagaagcug aggcucaaat t             21


<210>  17
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  17
tgcaggccug gcuggccagt t             21


<210>  18
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  18
tgcccccucg aacugguggt t             21


<210>  19
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  19
tuugcgguca ccacagccct t             21


<210>  20
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  20
tguugcgguc accacagcct t             21


<210>  21
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  21
tuguugcggu caccacagct t             21


<210>  22
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  22
tuuguugcgg ucaccacagt t             21


<210>  23
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  23
tcuuguugcg gucaccacat t             21


<210>  24
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  24
tgcuuguugc ggucaccact t             21


<210>  25
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  25
tggcuuguug cggucaccat t             21


<210>  26
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  26
taagcacuuu auugaguuct t             21


<210>  27
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  27
taaagcacuu uauugaguut t             21


<210>  28
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  28
tcaaagcacu uuauugagut t             21


<210>  29
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  29
tucaaagcac uuuauugagt t             21


<210>  30
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  30
tuucaaagca cuuuauugat t             21


<210>  31
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  31
tuuucaaagc acuuuauugt t             21


<210>  32
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  32
tuuuucaaag cacuuuauut t             21


<210>  33
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  33
tcauccgucc guugguccat t             21


<210>  34
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  34
tgcauccguc cguuggucct t             21


<210>  35
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  35
tggcauccgu ccguugguct t             21


<210>  36
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  36
tuggcauccg uccguuggut t             21


<210>  37
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  37
tauggcaucc guccguuggt t             21


<210>  38
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  38
tcauggcauc cguccguugt t             21


<210>  39
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  39
tucauggcau ccguccguut t             21


<210>  40
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  40
tcucauggca uccguccgut t             21


<210>  41
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  41
tcagagcccu cauggcauct t             21


<210>  42
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  42
tgcagagccc ucauggcaut t             21


<210>  43
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  43
taccccagga gcagcagagt t             21


<210>  44
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  44
tgggaagugg cagggcucct t             21


<210>  45
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  45
tugguacagc ugccgguggt t             21


<210>  46
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  46
tcugguccug aucaaaguut t             21


<210>  47
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  47
tgcugguccu gaucaaagut t             21


<210>  48
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  48
tucgcugguc cugaucaaat t             21


<210>  49
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  49
tccaucgcug guccugauct t             21


<210>  50
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  50
tcccaucgcu gguccugaut t             21


<210>  51
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  51
tuccccaucg cugguccugt t             21


<210>  52
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  52
tcuuucuugg gcuccaaact t             21


<210>  53
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  53
tacuuucuug ggcuccaaat t             21


<210>  54
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  54
tcugagcccg cggccaucat t             21


<210>  55
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  55
tuccgaggcc cacggcugat t             21


<210>  56
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  56
tcuccgaggc ccacggcugt t             21


<210>  57
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  57
tccuccgagg cccacggcut t             21


<210>  58
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  58
tgguggccuc cgaggcccat t             21


<210>  59
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  59
tagguggccu ccgaggccct t             21


<210>  60
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  60
tuagguggcc uccgaggcct t             21


<210>  61
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  61
tguagguggc cuccgaggct t             21


<210>  62
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  62
tguccccagu uccgcgcuut t             21


<210>  63
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  63
tuuccggcag aaggcguggt t             21


<210>  64
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  64
tguuccggca gaaggcgugt t             21


<210>  65
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  65
tgguuccggc agaaggcgut t             21


<210>  66
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  66
tccggguucc ggcagaaggt t             21


<210>  67
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  67
tuccggguuc cggcagaagt t             21


<210>  68
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  68
tguccggguu ccggcagaat t             21


<210>  69
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  69
tuguccgggu uccggcagat t             21


<210>  70
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  70
tcguuguccg gguuccggct t             21


<210>  71
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  71
tucguugucc ggguuccggt t             21


<210>  72
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  72
tuuccugguc agggaaggct t             21


<210>  73
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  73
tguuccuggu cagggaaggt t             21


<210>  74
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  74
tcguuccugg ucagggaagt t             21


<210>  75
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  75
tccguuccug gucagggaat t             21


<210>  76
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  76
tgccguuccu ggucagggat t             21


<210>  77
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  77
tcagugggcc guuccuggut t             21


<210>  78
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  78
tagcucagug ggccguucct t             21


<210>  79
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  79
tgaagacaga cucuugcggt t             21


<210>  80
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  80
tugccggcgc agaaacugut t             21


<210>  81
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  81
tggcgaugag gcugccggct t             21


<210>  82
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  82
tgggcgauga ggcugccggt t             21


<210>  83
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  83
tggggcgaug aggcugccgt t             21


<210>  84
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  84
tacccagcag ggggcgaugt t             21


<210>  85
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  85
tgcacccagc agggggcgat t             21


<210>  86
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  86
tagcacccag cagggggcgt t             21


<210>  87
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  87
tucagcaccc agcagggggt t             21


<210>  88
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  88
tccgagcacc accgucagat t             21


<210>  89
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  89
tggccgagca ccaccgucat t             21


<210>  90
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  90
tuggccgagc accaccguct t             21


<210>  91
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  91
tuccuggccg agcaccacct t             21


<210>  92
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  92
tcagcugccg uccgcaucct t             21


<210>  93
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  93
tggagcgcgc agcugccgut t             21


<210>  94
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  94
tacguaaggc gacaggagct t             21


<210>  95
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  95
tcugaacgua aggcgacagt t             21


<210>  96
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  96
tcuggcauau uccuccgcct t             21


<210>  97
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  97
tagcuggcau auuccuccgt t             21


<210>  98
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  98
tgaagcuggc auauuccuct t             21


<210>  99
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  99
tggaagcugg cauauuccut t             21


<210>  100
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  100
tcgggccucc ggaaucacct t             21


<210>  101
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  101
tgccacucuc ucacugcggt t             21


<210>  102
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  102
tagccacucu cucacugcgt t             21


<210>  103
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  103
taacagagcc gucauggcgt t             21


<210>  104
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  104
tcaacagagc cgucauggct t             21


<210>  105
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  105
tacaacagag ccgucauggt t             21


<210>  106
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  106
taacaacaga gccgucaugt t             21


<210>  107
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  107
tgaacaacag agccgucaut t             21


<210>  108
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  108
tggaacaaca gagccgucat t             21


<210>  109
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  109
tcggugguac ugaaagggat t             21


<210>  110
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  110
tuuguggaug cauuuguggt t             21


<210>  111
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  111
tcaagcagua uccccauugt t             21


<210>  112
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  112
tcuccaagca guauccccat t             21


<210>  113
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  113
tgcuccaagc aguaucccct t             21


<210>  114
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  114
tgggcuccaa gcaguaucct t             21


<210>  115
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  115
tguguuugcu gcaaugguct t             21


<210>  116
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  116
tuuccgguag guggccucct t             21


<210>  117
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  117
tguuccggua gguggccuct t             21


<210>  118
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  118
tuguuccggu agguggccut t             21


<210>  119
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  119
tcucagucau guuccgguat t             21


<210>  120
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  120
tgacgugugu cauuaucugt t             21


<210>  121
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  121
tggacgugug ucauuaucut t             21


<210>  122
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  122
tuggacgugu gucauuauct t             21


<210>  123
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  123
tauggacgug ugucauuaut t             21


<210>  124
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  124
taccauggac gugugucaut t             21


<210>  125
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  125
taguccgccc accacgcgct t             21


<210>  126
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  126
tuaguccgcc caccacgcgt t             21


<210>  127
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  127
tcuaguccgc ccaccacgct t             21


<210>  128
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  128
tacuaguccg cccaccacgt t             21


<210>  129
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  129
tcagagccac uaguccgcct t             21


<210>  130
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  130
tguuccucgg gcgcuggcct t             21


<210>  131
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  131
taguaccacu gucaguucct t             21


<210>  132
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  132
tucuugacca aguaccacut t             21


<210>  133
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  133
tgaucuugac caaguaccat t             21


<210>  134
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  134
tcgaucuuga ccaaguacct t             21


<210>  135
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  135
tggcgaucuu gaccaaguat t             21


<210>  136
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  136
tucgugaagg cgguaggagt t             21


<210>  137
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  137
tccucgugaa ggcgguaggt t             21


<210>  138
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  138
tcccucguga aggcgguagt t             21


<210>  139
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  139
tcgcagagca cugucucagt t             21


<210>  140
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  140
tcuucagccc ccucgaacut t             21


<210>  141
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  141
tucuucagcc cccucgaact t             21


<210>  142
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  142
tauucuucag cccccucgat t             21


<210>  143
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  143
tucuccgugc acguuagagt t             21


<210>  144
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  144
tcgucuccgu gcacguuagt t             21


<210>  145
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  145
tuggcgucuc cgugcacgut t             21


<210>  146
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  146
acuuucacuu ucuugggcut t             21


<210>  147
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  147
aggucuuuca cuuucuuggt t             21


<210>  148
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  148
uggucuuuca cuuucuuggt t             21


<210>  149
<211>  23
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  149
uggucuuuca cuuucuuggg cuc           23


<210>  150
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  150
tggucuuuca cuuucuuggg cucuau        26


<210>  151
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  151
tggucuuuca cuuucuuggg cucutt        26


<210>  152
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  152
tggucuuuca cuuucuuggg cucu          24


<210>  153
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  153
tggucuuuca cuuucuuggg cuc           23


<210>  154
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  154
tcuuucacuu ucuugggcuc caa           23


<210>  155
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  155
tucuuucacu uucuugggcu cca           23


<210>  156
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  156
tgucuuucac uuucuugggc ucc           23


<210>  157
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  157
tuggucuuuc acuuucuugg gcu           23


<210>  158
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  158
tgagaagcug aggcucaaag cac           23


<210>  159
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  159
tgagaagcug aggcucaaag cacuau        26


<210>  160
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  160
tggucuuuca cuuucuuggg cauaua        26


<210>  161
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-28
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  161
tggucuuuca cuuucuuggg cucauaua      28


<210>  162
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  162
tgagaagcug aggcucaaag cauaua        26


<210>  163
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-28
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  163
tgagaagcug aggcucaaag cacauaua      28


<210>  164
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  164
tggucuuuca cuuucuuggg cucua         25


<210>  165
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  165
tcacuuucuu gggcuccaaa caguau        26


<210>  166
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  166
tucacuuucu ugggcuccaa acauau        26


<210>  167
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  167
tuucacuuuc uugggcucca aacuau        26


<210>  168
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  168
tuuucacuuu cuugggcucc aaauau        26


<210>  169
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  169
tagcugaggc ucaaagcacu ucuuau        26


<210>  170
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  170
tgaagcugag gcucaaagca cuuuau        26


<210>  171
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  171
tuuguugcgg ucaccacagc ccguau        26


<210>  172
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  172
tgcuuguugc ggucaccaca gccuau        26


<210>  173
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  173
tggcuuguug cggucaccac agcuau        26


<210>  174
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  174
tggucuuuca cuuucuugg                19


<210>  175
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-18
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  175
tggucuuuca cuuucuug                 18


<210>  176
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-17
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  176
tggucuuuca cuuucuu                  17


<210>  177
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  177
uggucuuuca cuuucuuggg cucuau        26


<210>  178
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  178
ugaagcugag gcucaaagca cuuuau        26


<210>  179
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  179
ucacuuucuu gggcucca                 18


<210>  180
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  180
uucacuuucu ugggcucc                 18


<210>  181
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  181
uuucacuuuc uugggcuc                 18


<210>  182
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  182
uuuucacuuu cuugggcu                 18


<210>  183
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  183
ucuuucacuu ucuugggc                 18


<210>  184
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  184
uucuuucacu uucuuggg                 18


<210>  185
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  185
ugucuuucac uuucuugg                 18


<210>  186
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  186
uggucuuuca cuuucuug                 18


<210>  187
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  187
uuggucuuuc acuuucuu                 18


<210>  188
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  188
uagcugaggc ucaaagca                 18


<210>  189
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  189
ugaagcugag gcucaaag                 18


<210>  190
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  190
ugagaagcug aggcucaa                 18


<210>  191
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  191
uuuguugcgg ucaccaca                 18


<210>  192
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  192
ucuuguugcg gucaccac                 18


<210>  193
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  193
ugcuuguugc ggucacca                 18


<210>  194
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  194
uggcuuguug cggucacc                 18


<210>  195
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  195
ucacuuucuu gggcucc                  17


<210>  196
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  196
uucacuuucu ugggcuc                  17


<210>  197
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  197
uuucacuuuc uugggcu                  17


<210>  198
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  198
uuuucacuuu cuugggc                  17


<210>  199
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  199
ucuuucacuu ucuuggg                  17


<210>  200
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  200
uucuuucacu uucuugg                  17


<210>  201
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  201
ugucuuucac uuucuug                  17


<210>  202
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  202
uggucuuuca cuuucuu                  17


<210>  203
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  203
uuggucuuuc acuuucu                  17


<210>  204
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  204
uagcugaggc ucaaagc                  17


<210>  205
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  205
ugaagcugag gcucaaa                  17


<210>  206
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  206
ugagaagcug aggcuca                  17


<210>  207
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  207
uuuguugcgg ucaccac                  17


<210>  208
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  208
ucuuguugcg gucacca                  17


<210>  209
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  209
ugcuuguugc ggucacc                  17


<210>  210
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  210
uggcuuguug cggucac                  17


<210>  211
<211>  24
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  211
ggucuuucac uuucuugggc ucua          24


<210>  212
<211>  23
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  212
gucuuucacu uucuugggcu cua           23


<210>  213
<211>  22
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  213
ucuuucacuu ucuugggcuc ua            22


<210>  214
<211>  25
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  214
ggucuuucac uuucuugggc ucuau         25


<210>  215
<211>  24
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  215
gucuuucacu uucuugggcu cuau          24


<210>  216
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  216
uggucuuuca cuuucuuggg ctcuau        26


<210>  217
<211>  23
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  217
ggucuuucac uuucuugggc ucu           23


<210>  218
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-22
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  218
tggucuuuca cuuucuuggg cu            22


<210>  219
<211>  22
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  219
ggucuuucac uuucuugggc uc            22


<210>  220
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  220
uauggucuuu cacuuucuug ggcucu        26


<210>  221
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-21
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  221
tggucuuuca cuuucuuggg c             21


<210>  222
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  222
uggucuuuca cuuucuuggg cuucau        26


<210>  223
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  223
uuauggucuu ucacuuucuu gggcuc        26


<210>  224
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  224
ugauggucuu ucacuuucuu gggcuc        26


<210>  225
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  225
cccuggugug cuaccaccat               20


<210>  226
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  226
ccuggugugc uaccacccat               20


<210>  227
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  227
cuggugugcu accaccccat               20


<210>  228
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  228
uuggagccca agaaagugat               20


<210>  229
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  229
uggagcccaa gaaagugaat               20


<210>  230
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  230
ggagcccaag aaagugaaat               20


<210>  231
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  231
gagcccaaga aagugaaaat               20


<210>  232
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  232
agcccaagaa agugaaagat               20


<210>  233
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  233
gcccaagaaa gugaaagaat               20


<210>  234
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  234
cccaagaaag ugaaagacat               20


<210>  235
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  235
ccaagaaagu gaaagaccat               20


<210>  236
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  236
caagaaagug aaagaccaat               20


<210>  237
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  237
gugcuuugag ccucagcuat               20


<210>  238
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  238
ugcuuugagc cucagcuuat               20


<210>  239
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  239
gcuuugagcc ucagcuucat               20


<210>  240
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  240
uuugagccuc agcuucucat               20


<210>  241
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  241
cuggccagcc aggccugcat               20


<210>  242
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  242
ccaccaguuc gagggggcat               20


<210>  243
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  243
gggcuguggu gaccgcaaat               20


<210>  244
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  244
ggcuguggug accgcaacat               20


<210>  245
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  245
gcugugguga ccgcaacaat               20


<210>  246
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  246
cuguggugac cgcaacaaat               20


<210>  247
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  247
uguggugacc gcaacaagat               20


<210>  248
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  248
guggugaccg caacaagcat               20


<210>  249
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  249
uggugaccgc aacaagccat               20


<210>  250
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  250
gaacucaaua aagugcuuat               20


<210>  251
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  251
aacucaauaa agugcuuuat               20


<210>  252
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  252
acucaauaaa gugcuuugat               20


<210>  253
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  253
cucaauaaag ugcuuugaat               20


<210>  254
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  254
ucaauaaagu gcuuugaaat               20


<210>  255
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  255
caauaaagug cuuugaaaat               20


<210>  256
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  256
aauaaagugc uuugaaaaat               20


<210>  257
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  257
uggaccaacg gacggaugat               20


<210>  258
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  258
ggaccaacgg acggaugcat               20


<210>  259
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  259
gaccaacgga cggaugccat               20


<210>  260
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  260
accaacggac ggaugccaat               20


<210>  261
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  261
ccaacggacg gaugccauat               20


<210>  262
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  262
caacggacgg augccaugat               20


<210>  263
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  263
aacggacgga ugccaugaat               20


<210>  264
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  264
acggacggau gccaugagat               20


<210>  265
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  265
gaugccauga gggcucugat               20


<210>  266
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  266
augccaugag ggcucugcat               20


<210>  267
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  267
cucugcugcu ccugggguat               20


<210>  268
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  268
ggagcccugc cacuucccat               20


<210>  269
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  269
ccaccggcag cuguaccaat               20


<210>  270
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  270
aacuuugauc aggaccagat               20


<210>  271
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  271
acuuugauca ggaccagcat               20


<210>  272
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  272
uuugaucagg accagcgaat               20


<210>  273
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  273
gaucaggacc agcgauggat               20


<210>  274
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  274
aucaggacca gcgaugggat               20


<210>  275
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  275
caggaccagc gauggggaat               20


<210>  276
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  276
guuuggagcc caagaaagat               20


<210>  277
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  277
uuuggagccc aagaaaguat               20


<210>  278
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  278
ugauggccgc gggcucagat               20


<210>  279
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  279
ucagccgugg gccucggaat               20


<210>  280
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  280
cagccguggg ccucggagat               20


<210>  281
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  281
agccgugggc cucggaggat               20


<210>  282
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  282
ugggccucgg aggccaccat               20


<210>  283
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  283
gggccucgga ggccaccuat               20


<210>  284
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  284
ggccucggag gccaccuaat               20


<210>  285
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  285
gccucggagg ccaccuacat               20


<210>  286
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  286
aagcgcggaa cuggggacat               20


<210>  287
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  287
ccacgccuuc ugccggaaat               20


<210>  288
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  288
cacgccuucu gccggaacat               20


<210>  289
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  289
acgccuucug ccggaaccat               20


<210>  290
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  290
ccuucugccg gaacccggat               20


<210>  291
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  291
cuucugccgg aacccggaat               20


<210>  292
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  292
uucugccgga acccggacat               20


<210>  293
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  293
ucugccggaa cccggacaat               20


<210>  294
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  294
gccggaaccc ggacaacgat               20


<210>  295
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  295
ccggaacccg gacaacgaat               20


<210>  296
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  296
gccuucccug accaggaaat               20


<210>  297
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  297
ccuucccuga ccaggaacat               20


<210>  298
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  298
cuucccugac caggaacgat               20


<210>  299
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  299
uucccugacc aggaacggat               20


<210>  300
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  300
ucccugacca ggaacggcat               20


<210>  301
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  301
accaggaacg gcccacugat               20


<210>  302
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  302
ggaacggccc acugagcuat               20


<210>  303
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  303
ccgcaagagu cugucuucat               20


<210>  304
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  304
acaguuucug cgccggcaat               20


<210>  305
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  305
gccggcagcc ucaucgccat               20


<210>  306
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  306
ccggcagccu caucgcccat               20


<210>  307
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  307
cggcagccuc aucgccccat               20


<210>  308
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  308
caucgccccc ugcuggguat               20


<210>  309
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  309
ucgcccccug cugggugcat               20


<210>  310
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  310
cgcccccugc ugggugcuat               20


<210>  311
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  311
cccccugcug ggugcugaat               20


<210>  312
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  312
ucugacggug gugcucggat               20


<210>  313
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  313
ugacgguggu gcucggccat               20


<210>  314
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  314
gacgguggug cucggccaat               20


<210>  315
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  315
gguggugcuc ggccaggaat               20


<210>  316
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  316
ggaugcggac ggcagcugat               20


<210>  317
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  317
acggcagcug cgcgcuccat               20


<210>  318
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  318
gcuccugucg ccuuacguat               20


<210>  319
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  319
cugucgccuu acguucagat               20


<210>  320
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  320
ggcggaggaa uaugccagat               20


<210>  321
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  321
cggaggaaua ugccagcuat               20


<210>  322
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  322
gaggaauaug ccagcuucat               20


<210>  323
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  323
aggaauaugc cagcuuccat               20


<210>  324
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  324
ggugauuccg gaggcccgat               20


<210>  325
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  325
ccgcagugag agaguggcat               20


<210>  326
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  326
cgcagugaga gaguggcuat               20


<210>  327
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  327
cgccaugacg gcucuguuat               20


<210>  328
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  328
gccaugacgg cucuguugat               20


<210>  329
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  329
ccaugacggc ucuguuguat               20


<210>  330
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  330
caugacggcu cuguuguuat               20


<210>  331
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  331
augacggcuc uguuguucat               20


<210>  332
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  332
ugacggcucu guuguuccat               20


<210>  333
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  333
ucccuuucag uaccaccgat               20


<210>  334
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  334
ccacaaaugc auccacaaat               20


<210>  335
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  335
caauggggau acugcuugat               20


<210>  336
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  336
uggggauacu gcuuggagat               20


<210>  337
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  337
ggggauacug cuuggagcat               20


<210>  338
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  338
ggauacugcu uggagcccat               20


<210>  339
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  339
gaccauugca gcaaacacat               20


<210>  340
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  340
ggaggccacc uaccggaaat               20


<210>  341
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  341
gaggccaccu accggaacat               20


<210>  342
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  342
aggccaccua ccggaacaat               20


<210>  343
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  343
uaccggaaca ugacugagat               20


<210>  344
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  344
cagauaauga cacacgucat               20


<210>  345
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  345
agauaaugac acacguccat               20


<210>  346
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  346
gauaaugaca cacguccaat               20


<210>  347
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  347
auaaugacac acguccauat               20


<210>  348
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  348
augacacacg uccaugguat               20


<210>  349
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  349
gcgcguggug ggcggacuat               20


<210>  350
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  350
cgcguggugg gcggacuaat               20


<210>  351
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  351
gcgugguggg cggacuagat               20


<210>  352
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  352
cguggugggc ggacuaguat               20


<210>  353
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  353
ggcggacuag uggcucugat               20


<210>  354
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  354
ggccagcgcc cgaggaacat               20


<210>  355
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  355
ggaacugaca gugguacuat               20


<210>  356
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  356
agugguacuu ggucaagaat               20


<210>  357
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  357
ugguacuugg ucaagaucat               20


<210>  358
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  358
gguacuuggu caagaucgat               20


<210>  359
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  359
uacuugguca agaucgccat               20


<210>  360
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  360
cuccuaccgc cuucacgaat               20


<210>  361
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  361
ccuaccgccu ucacgaggat               20


<210>  362
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  362
cuaccgccuu cacgagggat               20


<210>  363
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  363
cugagacagu gcucugcgat               20


<210>  364
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  364
aguucgaggg ggcugaagat               20


<210>  365
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  365
guucgagggg gcugaagaat               20


<210>  366
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  366
ucgagggggc ugaagaauat               20


<210>  367
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  367
cucuaacgug cacggagaat               20


<210>  368
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  368
cuaacgugca cggagacgat               20


<210>  369
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  369
acgugcacgg agacgccaat               20


<210>  370
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-22
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  370
uauagcccaa gaaagugaaa gat           23


<210>  371
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  371
agcccaagaa agugaaagut               20


<210>  372
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-22
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  372
uaugcccaag aaagugaaag aat           23


<210>  373
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-22
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  373
uaucccaaga aagugaaaga cat           23


<210>  374
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-22
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  374
uauccaagaa agugaaagac cat           23


<210>  375
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  375
ccaagaaagu gaaagaccut               20


<210>  376
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-22
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  376
uaucaagaaa gugaaagacc aat           23


<210>  377
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-22
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  377
uauuuugagc cucagcuucu cat           23


<210>  378
<211>  24
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  378
gcccaagaaa gugaaagacc auau          24


<210>  379
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  379
uauaugccca agaaagugaa agacca        26


<210>  380
<211>  22
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  380
ugcccaagaa agugaaagac ca            22


<210>  381
<211>  21
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  381
gcccaagaaa gugaaagacc a             21


<210>  382
<211>  21
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  382
ggagcccaag aaagugaaag a             21


<210>  383
<211>  21
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  383
gagcccaaga aagugaaaga a             21


<210>  384
<211>  21
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  384
agcccaagaa agugaaagac a             21


<210>  385
<211>  21
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  385
cccaagaaag ugaaagacca a             21


<210>  386
<211>  21
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  386
gcuuugagcc ucagcuucuc a             21


<210>  387
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  387
uauaugcuuu gagccucagc uucuca        26


<210>  388
<211>  28
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  388
uauaugagcc caagaaagug aaagacca      28


<210>  389
<211>  28
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  389
uauaugugcu uugagccuca gcuucuca      28


<210>  390
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  390
uauauguuug gagcccaaga aaguga        26


<210>  391
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  391
uauauuuugg agcccaagaa agugaa        26


<210>  392
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  392
uauauuugga gcccaagaaa gugaaa        26


<210>  393
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  393
uauauuggag cccaagaaag ugaaaa        26


<210>  394
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  394
uauauaagug cuuugagccu cagcua        26


<210>  395
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  395
uauaugugcu uugagccuca gcuuca        26


<210>  396
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  396
uauauggcug uggugaccgc aacaaa        26


<210>  397
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  397
uauaucugug gugaccgcaa caagca        26


<210>  398
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  398
uauauugugg ugaccgcaac aagcca        26


<210>  399
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  399
uauuagccca agaaagugaa agacca        26


<210>  400
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  400
uauaagccca agaaagugaa agacca        26


<210>  401
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  401
auauugccca agaaagugaa agacca        26


<210>  402
<211>  22
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  402
ccaagaaagu gaaagaccau au            22


<210>  403
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  403
uggagcccaa gaaaguga                 18


<210>  404
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  404
ggagcccaag aaagugaa                 18


<210>  405
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  405
gagcccaaga aagugaaa                 18


<210>  406
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  406
agcccaagaa agugaaaa                 18


<210>  407
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  407
gcccaagaaa gugaaaga                 18


<210>  408
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  408
cccaagaaag ugaaagaa                 18


<210>  409
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  409
ccaagaaagu gaaagaca                 18


<210>  410
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  410
caagaaagug aaagacca                 18


<210>  411
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  411
aagaaaguga aagaccaa                 18


<210>  412
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  412
ugcuuugagc cucagcua                 18


<210>  413
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  413
cuuugagccu cagcuuca                 18


<210>  414
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  414
uugagccuca gcuucuca                 18


<210>  415
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  415
uguggugacc gcaacaaa                 18


<210>  416
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  416
guggugaccg caacaaga                 18


<210>  417
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  417
uggugaccgc aacaagca                 18


<210>  418
<211>  18
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  418
ggugaccgca acaagcca                 18


<210>  419
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  419
ggagcccaag aaaguga                  17


<210>  420
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  420
gagcccaaga aagugaa                  17


<210>  421
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  421
agcccaagaa agugaaa                  17


<210>  422
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  422
gcccaagaaa gugaaaa                  17


<210>  423
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  423
cccaagaaag ugaaaga                  17


<210>  424
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  424
ccaagaaagu gaaagaa                  17


<210>  425
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  425
caagaaagug aaagaca                  17


<210>  426
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  426
aagaaaguga aagacca                  17


<210>  427
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  427
agaaagugaa agaccaa                  17


<210>  428
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  428
gcuuugagcc ucagcua                  17


<210>  429
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  429
uuugagccuc agcuuca                  17


<210>  430
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  430
ugagccucag cuucuca                  17


<210>  431
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  431
guggugaccg caacaaa                  17


<210>  432
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  432
uggugaccgc aacaaga                  17


<210>  433
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  433
ggugaccgca acaagca                  17


<210>  434
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  434
gugaccgcaa caagcca                  17


<210>  435
<211>  25
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  435
auaugcccaa gaaagugaaa gacca         25


<210>  436
<211>  24
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  436
uaugcccaag aaagugaaag acca          24


<210>  437
<211>  23
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  437
augcccaaga aagugaaaga cca           23


<210>  438
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  438
uauaugccca agaaagugaa agauau        26


<210>  439
<211>  25
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  439
uauaugccca agaaagugaa agacc         25


<210>  440
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  440
uaugcccaag aaagugaaag accuau        26


<210>  441
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  441
uaugcccaag aaagugaaag accaau        26


<210>  442
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  442
uaugcccaag aaagugaaag accauu        26


<210>  443
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  443
uaugcccaag aaagugaaag accaua        26


<210>  444
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  444
uuagagccca agaaagugaa agacca        26


<210>  445
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  445
uuauugccca agaaagugaa agacca        26


<210>  446
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  446
uugaugccca agaaagugaa agacca        26


<210>  447
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  447
uaugagccca agaaagugaa agacca        26


<210>  448
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  448
auagagccca agaaagugaa agacca        26


<210>  449
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  449
augcccaaga aagugaaaga ccuauu        26


<210>  450
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  450
augcccaaga aagugaaaga ccugau        26


<210>  451
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  451
tggugguagc acaccagggt t             21


<210>  452
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  452
tgggugguag cacaccaggt t             21


<210>  453
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  453
tgggguggua gcacaccagt t             21


<210>  454
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  454
tcacuuucuu gggcuccaat t             21


<210>  455
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  455
tucacuuucu ugggcuccat t             21


<210>  456
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  456
tuucacuuuc uugggcucct t             21


<210>  457
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  457
tuuucacuuu cuugggcuct t             21


<210>  458
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  458
tcuuucacuu ucuugggcut t             21


<210>  459
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  459
tucuuucacu uucuugggct t             21


<210>  460
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  460
tgucuuucac uuucuugggt t             21


<210>  461
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  461
tggucuuuca cuuucuuggt t             21


<210>  462
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  462
tuggucuuuc acuuucuugt t             21


<210>  463
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  463
tagcugaggc ucaaagcact t             21


<210>  464
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  464
taagcugagg cucaaagcat t             21


<210>  465
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  465
tgaagcugag gcucaaagct t             21


<210>  466
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  466
tgagaagcug aggcucaaat t             21


<210>  467
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  467
tgcaggccug gcuggccagt t             21


<210>  468
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  468
tgcccccucg aacugguggt t             21


<210>  469
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  469
tuugcgguca ccacagccct t             21


<210>  470
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  470
tguugcgguc accacagcct t             21


<210>  471
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  471
tuguugcggu caccacagct t             21


<210>  472
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  472
tuuguugcgg ucaccacagt t             21


<210>  473
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  473
tcuuguugcg gucaccacat t             21


<210>  474
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  474
tgcuuguugc ggucaccact t             21


<210>  475
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  475
tggcuuguug cggucaccat t             21


<210>  476
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  476
taagcacuuu auugaguuct t             21


<210>  477
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  477
taaagcacuu uauugaguut t             21


<210>  478
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  478
tcaaagcacu uuauugagut t             21


<210>  479
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  479
tucaaagcac uuuauugagt t             21


<210>  480
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  480
tuucaaagca cuuuauugat t             21


<210>  481
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  481
tuuucaaagc acuuuauugt t             21


<210>  482
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  482
tuuuucaaag cacuuuauut t             21


<210>  483
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  483
tcauccgucc guugguccat t             21


<210>  484
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  484
tgcauccguc cguuggucct t             21


<210>  485
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  485
tggcauccgu ccguugguct t             21


<210>  486
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  486
tuggcauccg uccguuggut t             21


<210>  487
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  487
tauggcaucc guccguuggt t             21


<210>  488
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  488
tcauggcauc cguccguugt t             21


<210>  489
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  489
tucauggcau ccguccguut t             21


<210>  490
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  490
tcucauggca uccguccgut t             21


<210>  491
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  491
tcagagcccu cauggcauct t             21


<210>  492
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  492
tgcagagccc ucauggcaut t             21


<210>  493
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  493
taccccagga gcagcagagt t             21


<210>  494
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  494
tgggaagugg cagggcucct t             21


<210>  495
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  495
tugguacagc ugccgguggt t             21


<210>  496
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  496
tcugguccug aucaaaguut t             21


<210>  497
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  497
tgcugguccu gaucaaagut t             21


<210>  498
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  498
tucgcugguc cugaucaaat t             21


<210>  499
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  499
tccaucgcug guccugauct t             21


<210>  500
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  500
tcccaucgcu gguccugaut t             21


<210>  501
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  501
tuccccaucg cugguccugt t             21


<210>  502
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  502
tcuuucuugg gcuccaaact t             21


<210>  503
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  503
tacuuucuug ggcuccaaat t             21


<210>  504
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  504
tcugagcccg cggccaucat t             21


<210>  505
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  505
tuccgaggcc cacggcugat t             21


<210>  506
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  506
tcuccgaggc ccacggcugt t             21


<210>  507
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  507
tccuccgagg cccacggcut t             21


<210>  508
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  508
tgguggccuc cgaggcccat t             21


<210>  509
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  509
tagguggccu ccgaggccct t             21


<210>  510
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  510
tuagguggcc uccgaggcct t             21


<210>  511
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  511
tguagguggc cuccgaggct t             21


<210>  512
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  512
tguccccagu uccgcgcuut t             21


<210>  513
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  513
tuuccggcag aaggcguggt t             21


<210>  514
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  514
tguuccggca gaaggcgugt t             21


<210>  515
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  515
tgguuccggc agaaggcgut t             21


<210>  516
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  516
tccggguucc ggcagaaggt t             21


<210>  517
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  517
tuccggguuc cggcagaagt t             21


<210>  518
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  518
tguccggguu ccggcagaat t             21


<210>  519
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  519
tuguccgggu uccggcagat t             21


<210>  520
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  520
tcguuguccg gguuccggct t             21


<210>  521
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  521
tucguugucc ggguuccggt t             21


<210>  522
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  522
tuuccugguc agggaaggct t             21


<210>  523
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  523
tguuccuggu cagggaaggt t             21


<210>  524
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  524
tcguuccugg ucagggaagt t             21


<210>  525
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  525
tccguuccug gucagggaat t             21


<210>  526
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  526
tgccguuccu ggucagggat t             21


<210>  527
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  527
tcagugggcc guuccuggut t             21


<210>  528
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  528
tagcucagug ggccguucct t             21


<210>  529
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  529
tgaagacaga cucuugcggt t             21


<210>  530
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  530
tugccggcgc agaaacugut t             21


<210>  531
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  531
tggcgaugag gcugccggct t             21


<210>  532
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  532
tgggcgauga ggcugccggt t             21


<210>  533
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  533
tggggcgaug aggcugccgt t             21


<210>  534
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  534
tacccagcag ggggcgaugt t             21


<210>  535
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  535
tgcacccagc agggggcgat t             21


<210>  536
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  536
tagcacccag cagggggcgt t             21


<210>  537
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  537
tucagcaccc agcagggggt t             21


<210>  538
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  538
tccgagcacc accgucagat t             21


<210>  539
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  539
tggccgagca ccaccgucat t             21


<210>  540
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  540
tuggccgagc accaccguct t             21


<210>  541
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  541
tuccuggccg agcaccacct t             21


<210>  542
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  542
tcagcugccg uccgcaucct t             21


<210>  543
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  543
tggagcgcgc agcugccgut t             21


<210>  544
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  544
tacguaaggc gacaggagct t             21


<210>  545
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  545
tcugaacgua aggcgacagt t             21


<210>  546
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  546
tcuggcauau uccuccgcct t             21


<210>  547
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  547
tagcuggcau auuccuccgt t             21


<210>  548
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  548
tgaagcuggc auauuccuct t             21


<210>  549
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  549
tggaagcugg cauauuccut t             21


<210>  550
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  550
tcgggccucc ggaaucacct t             21


<210>  551
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  551
tgccacucuc ucacugcggt t             21


<210>  552
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  552
tagccacucu cucacugcgt t             21


<210>  553
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  553
taacagagcc gucauggcgt t             21


<210>  554
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  554
tcaacagagc cgucauggct t             21


<210>  555
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  555
tacaacagag ccgucauggt t             21


<210>  556
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  556
taacaacaga gccgucaugt t             21


<210>  557
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  557
tgaacaacag agccgucaut t             21


<210>  558
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  558
tggaacaaca gagccgucat t             21


<210>  559
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  559
tcggugguac ugaaagggat t             21


<210>  560
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  560
tuuguggaug cauuuguggt t             21


<210>  561
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  561
tcaagcagua uccccauugt t             21


<210>  562
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  562
tcuccaagca guauccccat t             21


<210>  563
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  563
tgcuccaagc aguaucccct t             21


<210>  564
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  564
tgggcuccaa gcaguaucct t             21


<210>  565
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  565
tguguuugcu gcaaugguct t             21


<210>  566
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  566
tuuccgguag guggccucct t             21


<210>  567
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  567
tguuccggua gguggccuct t             21


<210>  568
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  568
tuguuccggu agguggccut t             21


<210>  569
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  569
tcucagucau guuccgguat t             21


<210>  570
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  570
tgacgugugu cauuaucugt t             21


<210>  571
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  571
tggacgugug ucauuaucut t             21


<210>  572
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  572
tuggacgugu gucauuauct t             21


<210>  573
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  573
tauggacgug ugucauuaut t             21


<210>  574
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  574
taccauggac gugugucaut t             21


<210>  575
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  575
taguccgccc accacgcgct t             21


<210>  576
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  576
tuaguccgcc caccacgcgt t             21


<210>  577
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  577
tcuaguccgc ccaccacgct t             21


<210>  578
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  578
tacuaguccg cccaccacgt t             21


<210>  579
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  579
tcagagccac uaguccgcct t             21


<210>  580
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  580
tguuccucgg gcgcuggcct t             21


<210>  581
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  581
taguaccacu gucaguucct t             21


<210>  582
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  582
tucuugacca aguaccacut t             21


<210>  583
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  583
tgaucuugac caaguaccat t             21


<210>  584
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  584
tcgaucuuga ccaaguacct t             21


<210>  585
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  585
tcgaucuuga ccaaguacct t             21


<210>  586
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  586
tucgugaagg cgguaggagt t             21


<210>  587
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  587
tccucgugaa ggcgguaggt t             21


<210>  588
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  588
tcccucguga aggcgguagt t             21


<210>  589
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  589
tcgcagagca cugucucagt t             21


<210>  590
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  590
tcuucagccc ccucgaacut t             21


<210>  591
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  591
tucuucagcc cccucgaact t             21


<210>  592
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  592
tauucuucag cccccucgat t             21


<210>  593
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  593
tucuccgugc acguuagagt t             21


<210>  594
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  594
tcgucuccgu gcacguuagt t             21


<210>  595
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  595
tuggcgucuc cgugcacgut t             21


<210>  596
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  596
acuuucacuu ucuugggcut t             21


<210>  597
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  597
tcuuucacuu ucuugggcut t             21


<210>  598
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  598
tcuuucacuu ucuugggcut t             21


<210>  599
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  599
tucuuucacu uucuugggct t             21


<210>  600
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  600
tucuuucacu uucuugggct t             21


<210>  601
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  601
tgucuuucac uuucuugggt t             21


<210>  602
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  602
tgucuuucac uuucuugggt t             21


<210>  603
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  603
aggucuuuca cuuucuuggt t             21


<210>  604
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  604
tggucuuuca cuuucuuggt t             21


<210>  605
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  605
tggucuuuca cuuucuuggt t             21


<210>  606
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  606
tuggucuuuc acuuucuugt t             21


<210>  607
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  607
tuggucuuuc acuuucuugt t             21


<210>  608
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  608
tgagaagcug aggcucaaat t             21


<210>  609
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  609
tgagaagcug aggcucaaat t             21


<210>  610
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5'-vinyl phosphonate nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  610
tgucuuucac uuucuugggt t             21


<210>  611
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5'-vinyl phosphonate nucleotide"

<220>
<221>  modified_base
<222>  20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  611
tgucuuucac uuucuugggt t             21


<210>  612
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5'-vinyl phosphonate nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  612
tggucuuuca cuuucuuggt t             21


<210>  613
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5'-vinyl phosphonate nucleotide"

<220>
<221>  modified_base
<222>  20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  613
tggucuuuca cuuucuuggt t             21


<210>  614
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5'-vinyl phosphonate nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  614
tgagaagcug aggcucaaat t             21


<210>  615
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5'-vinyl phosphonate nucleotide"

<220>
<221>  modified_base
<222>  20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  615
tgagaagcug aggcucaaat t             21


<210>  616
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5'-vinyl phosphonate nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  616
tggucuuuca cuuucuuggt t             21


<210>  617
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5'-vinyl phosphonate nucleotide"

<220>
<221>  modified_base
<222>  20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  617
tggucuuuca cuuucuuggt t             21


<210>  618
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  618
tggucuuuca cuuucuuggt t             21


<210>  619
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  619
tgucuuucac uuucuugggt t             21


<210>  620
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  620
tggucuuuca cuuucuuggt t             21


<210>  621
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  621
tgagaagcug aggcucaaat t             21


<210>  622
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  622
tgucuuucac uuucuugggt t             21


<210>  623
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  623
tggucuuuca cuuucuuggt t             21


<210>  624
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  624
tgagaagcug aggcucaaat t             21


<210>  625
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  625
tggucuuuca cuuucuuggt t             21


<210>  626
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  626
uggucuuuca cuuucuuggt t             21


<210>  627
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  627
uggucuuuca cuuucuuggt t             21


<210>  628
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,12,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  628
uggucuuuca cuuucuuggg cuc           23


<210>  629
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,9,11,12,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  629
uggucuuuca cuuucuuggg cuc           23


<210>  630
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  630
tggucuuuca cuuucuuggt t             21


<210>  631
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  631
tggucuuuca cuuucuuggt t             21


<210>  632
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  632
tgucuuucac uuucuugggt t             21


<210>  633
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  633
tgagaagcug aggcucaaat t             21


<210>  634
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1
<223>  modified_base = "5'-phosphate nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  634
tggucuuuca cuuucuuggt t             21


<210>  635
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1
<223>  modified_base = "5'-phosphate nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  635
tggucuuuca cuuucuuggt t             21


<210>  636
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  636
tggucuuuca cuuucuuggg cucuau        26


<210>  637
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  637
tggucuuuca cuuucuuggg cucuau        26


<210>  638
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  638
tggucuuuca cuuucuuggg cucutt        26


<210>  639
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  639
tggucuuuca cuuucuuggg cucutt        26


<210>  640
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  640
tggucuuuca cuuucuuggg cucu          24


<210>  641
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  641
tggucuuuca cuuucuuggg cuc           23


<210>  642
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  642
tcuuucacuu ucuugggcuc caa           23


<210>  643
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  643
tucuuucacu uucuugggcu cca           23


<210>  644
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  644
tgucuuucac uuucuugggc ucc           23


<210>  645
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  645
tuggucuuuc acuuucuugg gcu           23


<210>  646
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  646
tgagaagcug aggcucaaag cac           23


<210>  647
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  647
tggucuuuca cuuucuuggg cucuau        26


<210>  648
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  648
tggucuuuca cuuucuuggg cucuau        26


<210>  649
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  649
tggucuuuca cuuucuuggg cucuau        26


<210>  650
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  8
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  650
tggucuuuca cuuucuuggg cucuau        26


<210>  651
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  9
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  651
tggucuuuca cuuucuuggg cucuau        26


<210>  652
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  10
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  652
tggucuuuca cuuucuuggg cucuau        26


<210>  653
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  11
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  653
tggucuuuca cuuucuuggg cucuau        26


<210>  654
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  654
tggucuuuca cuuucuuggg cucuau        26


<210>  655
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  13
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  655
tggucuuuca cuuucuuggg cucuau        26


<210>  656
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  656
tggucuuuca cuuucuuggg cucuau        26


<210>  657
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  15
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  657
tggucuuuca cuuucuuggg cucuau        26


<210>  658
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  658
tggucuuuca cuuucuuggg cucuau        26


<210>  659
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  659
tggucuuuca cuuucuuggg cucuau        26


<210>  660
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,14,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  660
tggucuuuca cuuucuuggg cucuau        26


<210>  661
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,13,15,17,19,21,23
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  661
tggucuuuca cuuucuuggg cucuau        26


<210>  662
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  662
tgagaagcug aggcucaaag cacuau        26


<210>  663
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  663
tgagaagcug aggcucaaag cacuau        26


<210>  664
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,14,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  664
tgagaagcug aggcucaaag cacuau        26


<210>  665
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,13,15,17,19,21,23
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,14,16,18,20,22,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  665
tgagaagcug aggcucaaag cacuau        26


<210>  666
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  666
tggucuuuca cuuucuuggg cauaua        26


<210>  667
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  667
tggucuuuca cuuucuuggg cauaua        26


<210>  668
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,25,27,28
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  668
tggucuuuca cuuucuuggg cucauaua      28


<210>  669
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  669
tgagaagcug aggcucaaag cauaua        26


<210>  670
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  670
tgagaagcug aggcucaaag cauaua        26


<210>  671
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,25,27,28
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  671
tgagaagcug aggcucaaag cacauaua      28


<210>  672
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  672
tggucuuuca cuuucuuggg cucuau        26


<210>  673
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  673
tggucuuuca cuuucuuggg cucua         25


<210>  674
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  674
tggucuuuca cuuucuuggg cucua         25


<210>  675
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  675
tcacuuucuu gggcuccaaa caguau        26


<210>  676
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  676
tucacuuucu ugggcuccaa acauau        26


<210>  677
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  677
tuucacuuuc uugggcucca aacuau        26


<210>  678
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  678
tuuucacuuu cuugggcucc aaauau        26


<210>  679
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  679
tagcugaggc ucaaagcacu ucuuau        26


<210>  680
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  680
tgaagcugag gcucaaagca cuuuau        26


<210>  681
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  681
tuuguugcgg ucaccacagc ccguau        26


<210>  682
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  682
tgcuuguugc ggucaccaca gccuau        26


<210>  683
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  683
tggcuuguug cggucaccac agcuau        26


<210>  684
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  684
tggucuuuca cuuucuuggg cucuau        26


<210>  685
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  685
tggucuuuca cuuucuuggg cucuau        26


<210>  686
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  686
tggucuuuca cuuucuuggg cucuau        26


<210>  687
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  687
tggucuuuca cuuucuuggg cucuau        26


<210>  688
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,13,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,14,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  688
tggucuuuca cuuucuuggg cucuau        26


<210>  689
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,13,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,14,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  689
tggucuuuca cuuucuuggg cucuau        26


<210>  690
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,15,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,14,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  690
tggucuuuca cuuucuuggg cucuau        26


<210>  691
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,15,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,14,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  691
tggucuuuca cuuucuuggg cucuau        26


<210>  692
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  692
tggucuuuca cuuucuuggg cucuau        26


<210>  693
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  693
tggucuuuca cuuucuuggg cucuau        26


<210>  694
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  13
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  694
tggucuuuca cuuucuuggg cucuau        26


<210>  695
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  10
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  695
tggucuuuca cuuucuuggg cucuau        26


<210>  696
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  4,6,8,10,14,16,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,5,7,9,11,12,13,15,17,18,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  696
tgucuuucac uuucuugggc ucc           23


<210>  697
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,5,7,9,11,12,13,15,17,19,20,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  697
tuggucuuuc acuuucuugg gcu           23


<210>  698
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  4,6,8,10,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,5,7,9,11,12,13,15,17,19,20,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  698
tgagaagcug aggcucaaag cac           23


<210>  699
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  23,24,25,26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,15,17,19,21,22
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  699
tggucuuuca cuuucuuggg cucuau        26


<210>  700
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,14,16,18,20,25
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,15,17,19,21,22,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  700
tggucuuuca cuuucuuggg cucuau        26


<210>  701
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,15,17,19,21,22,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  701
tggucuuuca cuuucuuggg cucuau        26


<210>  702
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,13,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  702
tggucuuuca cuuucuuggg cucuau        26


<210>  703
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (PaZ) modification"

<400>  703
tggucuuuca cuuucuuggt a             21


<210>  704
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end (PaZ) modification"

<400>  704
tggucuuuca cuuucuugg                19


<210>  705
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end (PaZ) modification"

<400>  705
tggucuuuca cuuucuugx                19


<210>  706
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  2,4,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end (PaZ) modification"

<400>  706
tggucuuuca cuuucuuxx                19


<210>  707
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (PaZ) modification"

<400>  707
tggucuuuca cuuucuuggt a             21


<210>  708
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end (PaZ) modification"

<400>  708
tggucuuuca cuuucuugg                19


<210>  709
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end (PaZ) modification"

<400>  709
tggucuuuca cuuucuugx                19


<210>  710
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end (PaZ) modification"

<400>  710
tggucuuuca cuuucuuxx                19


<210>  711
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  4,6,8,10,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,5,7,9,11,12,13,15,17,18,19,20,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  711
tggucuuuca cuuucuuggg cuc           23


<210>  712
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,12,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  712
uggucuuuca cuuucuuggg cucuau        26


<210>  713
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  713
ugaagcugag gcucaaagca cuuuau        26


<210>  714
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,5,7,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  714
tgaagcugag gcucaaagca cuuuau        26


<210>  715
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,8,9,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  715
tgaagcugag gcucaaagca cuuuau        26


<210>  716
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,10,11,13,15,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  716
tgaagcugag gcucaaagca cuuuau        26


<210>  717
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,18,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  717
tgaagcugag gcucaaagca cuuuau        26


<210>  718
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,12,14,16,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,5,7,8,9,10,11,13,15,17,18,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  718
tgaagcugag gcucaaagca cuuuau        26


<210>  719
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  719
ucacuuucuu gggcuccax                19


<210>  720
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  720
uucacuuucu ugggcuccx                19


<210>  721
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  721
uuucacuuuc uugggcucx                19


<210>  722
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  722
uuuucacuuu cuugggcux                19


<210>  723
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  723
ucuuucacuu ucuugggcx                19


<210>  724
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  724
uucuuucacu uucuugggx                19


<210>  725
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  725
ugucuuucac uuucuuggx                19


<210>  726
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  726
uggucuuuca cuuucuugx                19


<210>  727
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  727
uuggucuuuc acuuucuux                19


<210>  728
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  728
uagcugaggc ucaaagcax                19


<210>  729
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  729
ugaagcugag gcucaaagx                19


<210>  730
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  730
ugagaagcug aggcucaax                19


<210>  731
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  731
uuuguugcgg ucaccacax                19


<210>  732
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  732
ucuuguugcg gucaccacx                19


<210>  733
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  733
ugcuuguugc ggucaccax                19


<210>  734
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  734
uggcuuguug cggucaccx                19


<210>  735
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  735
ucacuuucuu gggcuccxx                19


<210>  736
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  736
uucacuuucu ugggcucxx                19


<210>  737
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  737
uuucacuuuc uugggcuxx                19


<210>  738
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  738
uuuucacuuu cuugggcxx                19


<210>  739
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  739
ucuuucacuu ucuugggxx                19


<210>  740
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  740
uucuuucacu uucuuggxx                19


<210>  741
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  741
ugucuuucac uuucuugxx                19


<210>  742
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  742
uggucuuuca cuuucuuxx                19


<210>  743
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  743
uuggucuuuc acuuucuxx                19


<210>  744
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  744
uagcugaggc ucaaagcxx                19


<210>  745
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  745
ugaagcugag gcucaaaxx                19


<210>  746
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  746
ugagaagcug aggcucaxx                19


<210>  747
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  747
uuuguugcgg ucaccacxx                19


<210>  748
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  748
ucuuguugcg gucaccaxx                19


<210>  749
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  749
ugcuuguugc ggucaccxx                19


<210>  750
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  750
uggcuuguug cggucacxx                19


<210>  751
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,24
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  751
tggucuuuca cuuucuuggg cucuau        26


<210>  752
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  752
tggucuuuca cuuucuuggg cucuau        26


<210>  753
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,16,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  753
uggucuuuca cuuucuuggg cucuau        26


<210>  754
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  754
tggucuuuca cuuucuuggg cucua         25


<210>  755
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,15,16,18,20,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  755
ggucuuucac uuucuugggc ucua          24


<210>  756
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,13,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,14,15,17,19,20,21,22
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  756
gucuuucacu uucuugggcu cua           23


<210>  757
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  22
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,12,15,17
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,14,16,18,19,20,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  757
ucuuucacuu ucuugggcuc ua            22


<210>  758
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  758
tggucuuuca cuuucuuggg cucua         25


<210>  759
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,15,16,18,20,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "3' end phosphate modification"

<400>  759
ggucuuucac uuucuugggc ucua          24


<210>  760
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' phosphorylated nucleotide"

<220>
<221>
<222>  2,4,6,8,10,12,13,16,18
<223>

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,14,15,17,19,20,21,22
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end phosphate modification"

<400>  760
gucuuucacu uucuugggcu cua           23


<210>  761
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  22
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' phosphorylated nucleotide"

<220>
<221>
<222>  1,3,5,7,9,11,12,15,17
<223>

<220>
<221>  modified_base
<222>  2,4,6,8,10,13,14,16,18,19,20,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end phosphate modification"

<400>  761
ucuuucacuu ucuugggcuc ua            22


<210>  762
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,15,16,18,20,21,22,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  762
ggucuuucac uuucuugggc ucuau         25


<210>  763
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,15,16,18,20,21,22,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  763
ggucuuucac uuucuugggc ucuau         25


<210>  764
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  764
tggucuuuca cuuucuuggg cucu          24


<210>  765
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  765
tggucuuuca cuuucuuggg cucu          24


<210>  766
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,5,7,9,11,12,13,15,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  766
uggucuuuca cuuucuuggg cucuau        26


<210>  767
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,12,13,15,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  767
uggucuuuca cuuucuuggg cucuau        26


<210>  768
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,8,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  768
uggucuuuca cuuucuuggg cucuau        26


<210>  769
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  769
uggucuuuca cuuucuuggg cucuau        26


<210>  770
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,6,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  770
uggucuuuca cuuucuuggg cucuau        26


<210>  771
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,10,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,11,12,13,15,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  771
uggucuuuca cuuucuuggg cucuau        26


<210>  772
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,6,10,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,7,8,9,11,12,13,15,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  772
uggucuuuca cuuucuuggg cucuau        26


<210>  773
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  773
uggucuuuca cuuucuuggg cucuau        26


<210>  774
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,5,6,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,7,8,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  774
uggucuuuca cuuucuuggg cucuau        26


<210>  775
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,5,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  775
uggucuuuca cuuucuuggg cucuau        26


<210>  776
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,5,6,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  776
uggucuuuca cuuucuuggg cucuau        26


<210>  777
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,6,8,10,11,12,14,16,17,18,19,20,21,22,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,21,22
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  777
ggucuuucac uuucuugggc ucuau         25


<210>  778
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,16,17,18,19,20,21,22,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  778
gucuuucacu uucuugggcu cuau          24


<210>  779
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  779
tggucuuuca cuuucuuggg cucuau        26


<210>  780
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,13,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,14,15,17,19,20,21,22,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  780
gucuuucacu uucuugggcu cuau          24


<210>  781
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  781
ucacuuucuu gggcuccxx                19


<210>  782
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  782
ucuuucacuu ucuugggxx                19


<210>  783
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  783
uggucuuuca cuuucuuxx                19


<210>  784
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  784
uuggucuuuc acuuucuxx                19


<210>  785
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,12,13,15,17,19,21,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  22,23
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  785
uggucuuuca cuuucuuggg ctcuau        26


<210>  786
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,12,13,15,17,19,21,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  22,23
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  786
uggucuuuca cuuucuuggg ctcuau        26


<210>  787
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,12,13,15,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  787
uggucuuuca cuuucuuggg cucuau        26


<210>  788
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  788
uggucuuuca cuuucuuggg cucuau        26


<210>  789
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  789
uggucuuuca cuuucuuggg cucuau        26


<210>  790
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,10,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  790
uggucuuuca cuuucuuggg cucuau        26


<210>  791
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  791
uggucuuuca cuuucuuggg cucuau        26


<210>  792
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  792
tggucuuuca cuuucuuggg cuc           23


<210>  793
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1
<223>  5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  793
tggucuuuca cuuucuuggg cuc           23


<210>  794
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,15,16,18,20,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  794
ggucuuucac uuucuugggc ucu           23


<210>  795
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1
<223>  5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,15,16,18,20,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  795
ggucuuucac uuucuugggc ucu           23


<210>  796
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  796
tggucuuuca cuuucuuggg cu            22


<210>  797
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1
<223>  5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  797
tggucuuuca cuuucuuggg cu            22


<210>  798
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,15,16,18,20,21,22
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  798
ggucuuucac uuucuugggc uc            22


<210>  799
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1
<223>  5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,15,16,18,20,21,22
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  799
ggucuuucac uuucuugggc uc            22


<210>  800
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,5,6,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  800
uggucuuuca cuuucuuggg cucuau        26


<210>  801
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,5,6,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  801
uggucuuuca cuuucuuggg cucuau        26


<210>  802
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,7,8,10,12,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,9,11,13,14,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,5,24,25
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  802
uauggucuuu cacuuucuug ggcucu        26


<210>  803
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  803
ucuuucacuu ucuugggxx                19


<210>  804
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end (PaZ) modification"

<400>  804
ucuuucacuu ucuugggxx                19


<210>  805
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,19
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  805
ucuuucacuu ucuugggxx                19


<210>  806
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  806
ucuuucacuu ucuugggx                 18


<210>  807
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,17
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  807
ucuuucacuu ucuuggg                  17


<210>  808
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  808
ucuuucacuu ucuugggxx                19


<210>  809
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c3)(c3)s(PaZ) modification"

<400>  809
ucuuucacuu ucuuggg                  17


<210>  810
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Sp9)s(PaZ) modification"

<400>  810
ucuuucacuu ucuuggg                  17


<210>  811
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Sp18)s(PaZ) modification"

<400>  811
ucuuucacuu ucuuggg                  17


<210>  812
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c12)s(PaZ) modification"

<400>  812
ucuuucacuu ucuuggg                  17


<210>  813
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c3)s(PaZ) modification"

<400>  813
ucuuucacuu ucuuggg                  17


<210>  814
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end (PaZ) modification"

<400>  814
ucuuucacuu ucuugggxx                19


<210>  815
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,6,8,12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,7,9,10,11,13,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  815
ucuuucacuu ucuugggxx                19


<210>  816
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,12,13,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  816
uggucuuuca cuuucuuxx                19


<210>  817
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  817
uggucuuuca cuuucuuxx                19


<210>  818
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  818
tggucuuuca cuuucuuggg c             21


<210>  819
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1
<223>  5' phosphorylated nucleotide"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  819
tggucuuuca cuuucuuggg c             21


<210>  820
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,10,12,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,11,13,14,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,5,24,25
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  820
uauggucuuu cacuuucuug ggcucu        26


<210>  821
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,21,22
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  821
uggucuuuca cuuucuuggg cucuau        26


<210>  822
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,20,21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  822
uggucuuuca cuuucuuggg cucuau        26


<210>  823
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  823
uggucuuuca cuuucuuggg cucuau        26


<210>  824
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  824
uggucuuuca cuuucuuggg cucuau        26


<210>  825
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  825
uggucuuuca cuuucuuggg cucuau        26


<210>  826
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5'-vinyl phosphonate nucleotide"

<220>
<221>  modified_base
<222>  3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  826
tggucuuuca cuuucuuggg cucuau        26


<210>  827
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5'-vinyl phosphonate nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  827
tggucuuuca cuuucuuggg cucuau        26


<210>  828
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  828
tggucuuuca cuuucuuggg cucuau        26


<210>  829
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  829
uggucuuuca cuuucuuggg cuucau        26


<210>  830
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  830
uggucuuuca cuuucuuggg cucuau        26


<210>  831
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  831
tggucuuuca cuuucuuggg cauaua        26


<210>  832
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,15,18,20
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,16,17,19,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  832
tggucuuuca cuuucuuggg cucuau        26


<210>  833
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,11,13,17
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,6,7,8,9,10,12,14,15,16,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  833
uuauggucuu ucacuuucuu gggcuc        26


<210>  834
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,11,13,17
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,4,6,7,8,9,10,12,14,15,16,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  834
ugauggucuu ucacuuucuu gggcuc        26


<210>  835
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<400>  835
uggucuuuca cuuucuuggg cucuau        26


<210>  836
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (cy5-c6) modification"

<400>  836
uggucuuuca cuuucuuggg cucuau        26


<210>  837
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  837
cccuggugug cuaccaccat               20


<210>  838
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  838
ccuggugugc uaccacccat               20


<210>  839
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  839
cuggugugcu accaccccat               20


<210>  840
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  840
uuggagccca agaaagugat               20


<210>  841
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  841
uggagcccaa gaaagugaat               20


<210>  842
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  842
ggagcccaag aaagugaaat               20


<210>  843
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  843
gagcccaaga aagugaaaat               20


<210>  844
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  844
agcccaagaa agugaaagat               20


<210>  845
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  845
gcccaagaaa gugaaagaat               20


<210>  846
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  846
cccaagaaag ugaaagacat               20


<210>  847
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  847
ccaagaaagu gaaagaccat               20


<210>  848
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  848
caagaaagug aaagaccaat               20


<210>  849
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  849
gugcuuugag ccucagcuat               20


<210>  850
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  850
ugcuuugagc cucagcuuat               20


<210>  851
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  851
gcuuugagcc ucagcuucat               20


<210>  852
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  852
uuugagccuc agcuucucat               20


<210>  853
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  853
cuggccagcc aggccugcat               20


<210>  854
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  854
ccaccaguuc gagggggcat               20


<210>  855
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  855
gggcuguggu gaccgcaaat               20


<210>  856
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  856
ggcuguggug accgcaacat               20


<210>  857
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  857
gcugugguga ccgcaacaat               20


<210>  858
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  858
cuguggugac cgcaacaaat               20


<210>  859
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  859
uguggugacc gcaacaagat               20


<210>  860
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  860
guggugaccg caacaagcat               20


<210>  861
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  861
uggugaccgc aacaagccat               20


<210>  862
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  862
gaacucaaua aagugcuuat               20


<210>  863
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  863
aacucaauaa agugcuuuat               20


<210>  864
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  864
acucaauaaa gugcuuugat               20


<210>  865
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  865
cucaauaaag ugcuuugaat               20


<210>  866
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  866
ucaauaaagu gcuuugaaat               20


<210>  867
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  867
caauaaagug cuuugaaaat               20


<210>  868
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  868
aauaaagugc uuugaaaaat               20


<210>  869
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  869
uggaccaacg gacggaugat               20


<210>  870
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  870
ggaccaacgg acggaugcat               20


<210>  871
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  871
gaccaacgga cggaugccat               20


<210>  872
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  872
accaacggac ggaugccaat               20


<210>  873
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  873
ccaacggacg gaugccauat               20


<210>  874
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  874
caacggacgg augccaugat               20


<210>  875
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  875
aacggacgga ugccaugaat               20


<210>  876
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  876
acggacggau gccaugagat               20


<210>  877
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  877
gaugccauga gggcucugat               20


<210>  878
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  878
augccaugag ggcucugcat               20


<210>  879
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  879
cucugcugcu ccugggguat               20


<210>  880
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  880
ggagcccugc cacuucccat               20


<210>  881
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  881
ccaccggcag cuguaccaat               20


<210>  882
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  882
aacuuugauc aggaccagat               20


<210>  883
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  883
acuuugauca ggaccagcat               20


<210>  884
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  884
uuugaucagg accagcgaat               20


<210>  885
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  885
gaucaggacc agcgauggat               20


<210>  886
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  886
aucaggacca gcgaugggat               20


<210>  887
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  887
caggaccagc gauggggaat               20


<210>  888
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  888
guuuggagcc caagaaagat               20


<210>  889
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  889
uuuggagccc aagaaaguat               20


<210>  890
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  890
ugauggccgc gggcucagat               20


<210>  891
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  891
ucagccgugg gccucggaat               20


<210>  892
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  892
cagccguggg ccucggagat               20


<210>  893
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  893
agccgugggc cucggaggat               20


<210>  894
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  894
ugggccucgg aggccaccat               20


<210>  895
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  895
gggccucgga ggccaccuat               20


<210>  896
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  896
ggccucggag gccaccuaat               20


<210>  897
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  897
gccucggagg ccaccuacat               20


<210>  898
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  898
aagcgcggaa cuggggacat               20


<210>  899
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  899
ccacgccuuc ugccggaaat               20


<210>  900
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  900
cacgccuucu gccggaacat               20


<210>  901
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  901
acgccuucug ccggaaccat               20


<210>  902
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  902
ccuucugccg gaacccggat               20


<210>  903
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  903
cuucugccgg aacccggaat               20


<210>  904
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  904
uucugccgga acccggacat               20


<210>  905
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  905
ucugccggaa cccggacaat               20


<210>  906
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  906
gccggaaccc ggacaacgat               20


<210>  907
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  907
ccggaacccg gacaacgaat               20


<210>  908
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  908
gccuucccug accaggaaat               20


<210>  909
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  909
ccuucccuga ccaggaacat               20


<210>  910
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  910
cuucccugac caggaacgat               20


<210>  911
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  911
uucccugacc aggaacggat               20


<210>  912
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  912
ucccugacca ggaacggcat               20


<210>  913
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  913
accaggaacg gcccacugat               20


<210>  914
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  914
ggaacggccc acugagcuat               20


<210>  915
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  915
ccgcaagagu cugucuucat               20


<210>  916
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  916
acaguuucug cgccggcaat               20


<210>  917
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  917
gccggcagcc ucaucgccat               20


<210>  918
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  918
ccggcagccu caucgcccat               20


<210>  919
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  919
cggcagccuc aucgccccat               20


<210>  920
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  920
caucgccccc ugcuggguat               20


<210>  921
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  921
ucgcccccug cugggugcat               20


<210>  922
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  922
cgcccccugc ugggugcuat               20


<210>  923
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  923
cccccugcug ggugcugaat               20


<210>  924
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  924
ucugacggug gugcucggat               20


<210>  925
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  925
ugacgguggu gcucggccat               20


<210>  926
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  926
gacgguggug cucggccaat               20


<210>  927
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  927
gguggugcuc ggccaggaat               20


<210>  928
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  928
ggaugcggac ggcagcugat               20


<210>  929
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  929
acggcagcug cgcgcuccat               20


<210>  930
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  930
gcuccugucg ccuuacguat               20


<210>  931
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  931
cugucgccuu acguucagat               20


<210>  932
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  932
ggcggaggaa uaugccagat               20


<210>  933
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  933
cggaggaaua ugccagcuat               20


<210>  934
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  934
gaggaauaug ccagcuucat               20


<210>  935
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  935
aggaauaugc cagcuuccat               20


<210>  936
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  936
ggugauuccg gaggcccgat               20


<210>  937
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  937
ccgcagugag agaguggcat               20


<210>  938
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  938
cgcagugaga gaguggcuat               20


<210>  939
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  939
cgccaugacg gcucuguuat               20


<210>  940
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  940
gccaugacgg cucuguugat               20


<210>  941
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  941
ccaugacggc ucuguuguat               20


<210>  942
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  942
caugacggcu cuguuguuat               20


<210>  943
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  943
augacggcuc uguuguucat               20


<210>  944
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  944
ugacggcucu guuguuccat               20


<210>  945
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  945
ucccuuucag uaccaccgat               20


<210>  946
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  946
ccacaaaugc auccacaaat               20


<210>  947
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  947
caauggggau acugcuugat               20


<210>  948
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  948
uggggauacu gcuuggagat               20


<210>  949
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  949
ggggauacug cuuggagcat               20


<210>  950
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  950
ggauacugcu uggagcccat               20


<210>  951
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  951
gaccauugca gcaaacacat               20


<210>  952
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  952
ggaggccacc uaccggaaat               20


<210>  953
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  953
gaggccaccu accggaacat               20


<210>  954
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  954
aggccaccua ccggaacaat               20


<210>  955
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  955
uaccggaaca ugacugagat               20


<210>  956
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  956
cagauaauga cacacgucat               20


<210>  957
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  957
agauaaugac acacguccat               20


<210>  958
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  958
gauaaugaca cacguccaat               20


<210>  959
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  959
auaaugacac acguccauat               20


<210>  960
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  960
augacacacg uccaugguat               20


<210>  961
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  961
gcgcguggug ggcggacuat               20


<210>  962
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  962
cgcguggugg gcggacuaat               20


<210>  963
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  963
gcgugguggg cggacuagat               20


<210>  964
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  964
cguggugggc ggacuaguat               20


<210>  965
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  965
ggcggacuag uggcucugat               20


<210>  966
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  966
ggccagcgcc cgaggaacat               20


<210>  967
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  967
ggaacugaca gugguacuat               20


<210>  968
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  968
agugguacuu ggucaagaat               20


<210>  969
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  969
ugguacuugg ucaagaucat               20


<210>  970
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  970
gguacuuggu caagaucgat               20


<210>  971
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  971
uacuugguca agaucgccat               20


<210>  972
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  972
cuccuaccgc cuucacgaat               20


<210>  973
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  973
ccuaccgccu ucacgaggat               20


<210>  974
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  974
cuaccgccuu cacgagggat               20


<210>  975
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  975
cugagacagu gcucugcgat               20


<210>  976
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  976
aguucgaggg ggcugaagat               20


<210>  977
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  977
guucgagggg gcugaagaat               20


<210>  978
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  978
ucgagggggc ugaagaauat               20


<210>  979
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  979
cucuaacgug cacggagaat               20


<210>  980
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  980
cuaacgugca cggagacgat               20


<210>  981
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  981
acgugcacgg agacgccaat               20


<210>  982
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  982
uauagcccaa gaaagugaaa gat           23


<210>  983
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  983
agcccaagaa agugaaagut               20


<210>  984
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  984
uaugcccaag aaagugaaag aat           23


<210>  985
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  985
uaucccaaga aagugaaaga cat           23


<210>  986
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  986
uauccaagaa agugaaagac cat           23


<210>  987
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<400>  987
ccaagaaagu gaaagaccut               20


<210>  988
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  988
uaucaagaaa gugaaagacc aat           23


<210>  989
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  989
uauuuugagc cucagcuucu cat           23


<210>  990
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  21,22
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  990
uaucccaaga aagugaaaga cat           23


<210>  991
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  21,22
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  991
uauccaagaa agugaaagac cat           23


<210>  992
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  21,22
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  992
uauuuugagc cucagcuucu cat           23


<210>  993
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  21,22
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  993
uaucccaaga aagugaaaga cat           23


<210>  994
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  21,22
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  994
uauccaagaa agugaaagac cat           23


<210>  995
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  21,22
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  995
uauuuugagc cucagcuucu cat           23


<210>  996
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  22
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "3' end (tEg-chol) modification"

<400>  996
gcccaagaaa gugaaagacc axuau         25


<210>  997
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  997
uauccaagaa agugaaagac cat           23


<210>  998
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  998
uaucccaaga aagugaaaga cat           23


<210>  999
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  999
uauuuugagc cucagcuucu cat           23


<210>  1000
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-SS-c6) modification"

<400>  1000
ccaagaaagu gaaagaccat               20


<210>  1001
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  20
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<400>  1001
ccaagaaagu gaaagaccat               20


<210>  1002
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-c6)(tEg-chol) modification"

<400>  1002
uauaugccca agaaagugaa agacca        26


<210>  1003
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1003
uauaugccca agaaagugaa agacca        26


<210>  1004
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,11,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,13,15,17,19,21
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  22
<223>  /mod_base = "3' end (c6-SS-c6)(tEg-chol) modification"

<400>  1004
ugcccaagaa agugaaagac ca            22


<210>  1005
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-SS-c6)(tEg-chol) modification"

<400>  1005
gcccaagaaa gugaaagacc a             21


<210>  1006
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1006
uauaugccca agaaagugaa agacca        26


<210>  1007
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1007
ggagcccaag aaagugaaag a             21


<210>  1008
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1008
gagcccaaga aagugaaaga a             21


<210>  1009
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1009
agcccaagaa agugaaagac a             21


<210>  1010
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1010
gcccaagaaa gugaaagacc a             21


<210>  1011
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1011
cccaagaaag ugaaagacca a             21


<210>  1012
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1012
gcuuugagcc ucagcuucuc a             21


<210>  1013
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1013
uauaugccca agaaagugaa agacca        26


<210>  1014
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1014
ggagcccaag aaagugaaag a             21


<210>  1015
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1015
gagcccaaga aagugaaaga a             21


<210>  1016
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1016
agcccaagaa agugaaagac a             21


<210>  1017
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1017
gcccaagaaa gugaaagacc a             21


<210>  1018
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1018
cccaagaaag ugaaagacca a             21


<210>  1019
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1019
gcuuugagcc ucagcuucuc a             21


<210>  1020
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1020
uauaugccca agaaagugaa agacca        26


<210>  1021
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag3) modification"

<400>  1021
uauaugccca agaaagugaa agacca        26


<210>  1022
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-Nag3) modification"

<400>  1022
uauaugccca agaaagugaa agacca        26


<210>  1023
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1023
uauaugccca agaaagugaa agacca        26


<210>  1024
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1024
uauaugccca agaaagugaa agacca        26


<210>  1025
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,13,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1025
uauaugccca agaaagugaa agacca        26


<210>  1026
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,9,11,13,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,8,10,12,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1026
uauaugccca agaaagugaa agacca        26


<210>  1027
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1027
uauaugccca agaaagugaa agacca        26


<210>  1028
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1028
uauaugccca agaaagugaa agacca        26


<210>  1029
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1029
uauaugccca agaaagugaa agacca        26


<210>  1030
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  16
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,14,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1030
uauaugccca agaaagugaa agacca        26


<210>  1031
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  15
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1031
uauaugccca agaaagugaa agacca        26


<210>  1032
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1032
uauaugccca agaaagugaa agacca        26


<210>  1033
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  13
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1033
uauaugccca agaaagugaa agacca        26


<210>  1034
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1034
uauaugccca agaaagugaa agacca        26


<210>  1035
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1035
uauaugcuuu gagccucagc uucuca        26


<210>  1036
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1036
uauaugcuuu gagccucagc uucuca        26


<210>  1037
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,13,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1037
uauaugcuuu gagccucagc uucuca        26


<210>  1038
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,9,11,13,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,8,10,12,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1038
uauaugcuuu gagccucagc uucuca        26


<210>  1039
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag4) modification"

<400>  1039
uauaugccca agaaagugaa agacca        26


<210>  1040
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1040
uauaugccca agaaagugaa agacca        26


<210>  1041
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,7,9,11,13,15,17,19,21,23,25,27
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  28
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  4,5
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1041
uauaugagcc caagaaagug aaagacca      28


<210>  1042
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1042
uauaugcuuu gagccucagc uucuca        26


<210>  1043
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,7,9,11,13,15,17,19,21,23,25,27
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  28
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  4,5
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1043
uauaugugcu uugagccuca gcuucuca      28


<210>  1044
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-SMPt-alk) modification"

<400>  1044
gcuuugagcc ucagcuucuc a             21


<210>  1045
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SMPt-alk) modification"

<400>  1045
uauaugccca agaaagugaa agacca        26


<210>  1046
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"26

<400>  1046
uauaugccca agaaagugaa agacca        26


<210>  1047
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1047
uauauguuug gagcccaaga aaguga        26


<210>  1048
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1048
uauauuuugg agcccaagaa agugaa        26


<210>  1049
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1049
uauauuugga gcccaagaaa gugaaa        26


<210>  1050
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1050
uauauuggag cccaagaaag ugaaaa        26


<210>  1051
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1051
uauauaagug cuuugagccu cagcua        26


<210>  1052
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1052
uauaugugcu uugagccuca gcuuca        26


<210>  1053
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1053
uauauggcug uggugaccgc aacaaa        26


<210>  1054
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1054
uauaucugug gugaccgcaa caagca        26


<210>  1055
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1055
uauauugugg ugaccgcaac aagcca        26


<210>  1056
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1056
uauaugccca agaaagugaa agacca        26


<210>  1057
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1057
uauaugccca agaaagugaa agacca        26


<210>  1058
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1058
uauaugccca agaaagugaa agacca        26


<210>  1059
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1059
uauaugccca agaaagugaa agacca        26


<210>  1060
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,13,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,14,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1060
uauaugccca agaaagugaa agacca        26


<210>  1061
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,13,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,14,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1061
uauaugccca agaaagugaa agacca        26


<210>  1062
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,13,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1062
uauaugccca agaaagugaa agacca        26


<210>  1063
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,13,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,12,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1063
uauaugccca agaaagugaa agacca        26


<210>  1064
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,11,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1064
uauaugccca agaaagugaa agacca        26


<210>  1065
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,11,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1065
uauaugccca agaaagugaa agacca        26


<210>  1066
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1066
uauauguuug gagcccaaga aaguga        26


<210>  1067
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1067
uauauuuugg agcccaagaa agugaa        26


<210>  1068
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1068
uauauuugga gcccaagaaa gugaaa        26


<210>  1069
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1069
uauauuggag cccaagaaag ugaaaa        26


<210>  1070
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1070
uauauaagug cuuugagccu cagcua        26


<210>  1071
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1071
uauaugugcu uugagccuca gcuuca        26


<210>  1072
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1072
uauauggcug uggugaccgc aacaaa        26


<210>  1073
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1073
uauaucugug gugaccgcaa caagca        26


<210>  1074
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1074
uauauugugg ugaccgcaac aagcca        26


<210>  1075
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1075
gcccaagaaa gugaaagacc a             21


<210>  1076
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1076
uauaugccca agaaagugaa agacca        26


<210>  1077
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Me-alk-SS-c6) modification"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1077
gcccaagaaa gugaaagacc a             21


<210>  1078
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  15
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1078
uauaugccca agaaagugaa agacca        26


<210>  1079
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1079
uauaugccca agaaagugaa agacca        26


<210>  1080
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  13
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1080
uauaugccca agaaagugaa agacca        26


<210>  1081
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1081
uauaugccca agaaagugaa agacca        26


<210>  1082
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1082
agcccaagaa agugaaagac a             21


<210>  1083
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1083
agcccaagaa agugaaagac a             21


<210>  1084
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,9,10,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1084
cccaagaaag ugaaagacca a             21


<210>  1085
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,9,10,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1085
cccaagaaag ugaaagacca a             21


<210>  1086
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,2,3,4,5
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1086
uauuagccca agaaagugaa agacca        26


<210>  1087
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  5
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1087
uauaagccca agaaagugaa agacca        26


<210>  1088
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  5
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1088
uauaagccca agaaagugaa agacca        26


<210>  1089
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,2,3,4,5
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1089
auauugccca agaaagugaa agacca        26


<210>  1090
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  5
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1090
auauugccca agaaagugaa agacca        26


<210>  1091
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  5
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,7,9,11,13,14,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1091
auauugccca agaaagugaa agacca        26


<210>  1092
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18,20,22
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  22
<223>  /mod_base = "3' end (tEg-chol) modification"

<400>  1092
ccaagaaagu gaaagaccau au            22


<210>  1093
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,5,9,10,11,15,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,6,7,8,12,13,14,16,17,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1093
gcccaagaaa gugaaagacc a             21


<210>  1094
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,5,9,10,11,15,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,6,7,8,12,13,14,16,17,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1094
gcccaagaaa gugaaagacc a             21


<210>  1095
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1095
uauaugccca agaaagugaa agacca        26


<210>  1096
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (DBcO-tEg) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1096
uauaugccca agaaagugaa agacca        26


<210>  1097
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1097
uauaugugcu uugagccuca gcuuca        26


<210>  1098
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1098
uauaugugcu uugagccuca gcuuca        26


<210>  1099
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,8,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1099
uauaugugcu uugagccuca gcuuca        26


<210>  1100
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1100
uauaugugcu uugagccuca gcuuca        26


<210>  1101
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (DBcO-tEg) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1101
uauaugugcu uugagccuca gcuuca        26


<210>  1102
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1102
uggagcccaa gaaaguga                 18


<210>  1103
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1103
ggagcccaag aaagugaa                 18


<210>  1104
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1104
gagcccaaga aagugaaa                 18


<210>  1105
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1105
agcccaagaa agugaaaa                 18


<210>  1106
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1106
gcccaagaaa gugaaaga                 18


<210>  1107
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1107
cccaagaaag ugaaagaa                 18


<210>  1108
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1108
ccaagaaagu gaaagaca                 18


<210>  1109
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1109
caagaaagug aaagacca                 18


<210>  1110
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1110
aagaaaguga aagaccaa                 18


<210>  1111
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1111
ugcuuugagc cucagcua                 18


<210>  1112
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1112
cuuugagccu cagcuuca                 18


<210>  1113
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1113
uugagccuca gcuucuca                 18


<210>  1114
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1114
uguggugacc gcaacaaa                 18


<210>  1115
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1115
guggugaccg caacaaga                 18


<210>  1116
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1116
uggugaccgc aacaagca                 18


<210>  1117
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1117
ggugaccgca acaagcca                 18


<210>  1118
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1118
ggagcccaag aaaguga                  17


<210>  1119
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1119
gagcccaaga aagugaa                  17


<210>  1120
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1120
agcccaagaa agugaaa                  17


<210>  1121
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1121
gcccaagaaa gugaaaa                  17


<210>  1122
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1122
cccaagaaag ugaaaga                  17


<210>  1123
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1123
ccaagaaagu gaaagaa                  17


<210>  1124
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1124
caagaaagug aaagaca                  17


<210>  1125
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1125
aagaaaguga aagacca                  17


<210>  1126
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1126
agaaagugaa agaccaa                  17


<210>  1127
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1127
gcuuugagcc ucagcua                  17


<210>  1128
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1128
uuugagccuc agcuuca                  17


<210>  1129
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1129
ugagccucag cuucuca                  17


<210>  1130
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1130
guggugaccg caacaaa                  17


<210>  1131
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1131
uggugaccgc aacaaga                  17


<210>  1132
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1132
ggugaccgca acaagca                  17


<210>  1133
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1133
gugaccgcaa caagcca                  17


<210>  1134
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1134
uauaugccca agaaagugaa agacca        26


<210>  1135
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1135
uauaugugcu uugagccuca gcuuca        26


<210>  1136
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1136
uauaugccca agaaagugaa agacca        26


<210>  1137
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1137
uauaugugcu uugagccuca gcuuca        26


<210>  1138
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Spermine) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1138
uauaugugcu uugagccuca gcuuca        26


<210>  1139
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Spermine)2 modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1139
uauaugugcu uugagccuca gcuuca        26


<210>  1140
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Spermine)3 modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1140
uauaugugcu uugagccuca gcuuca        26


<210>  1141
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,11,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1141
uauaugccca agaaagugaa agacca        26


<210>  1142
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  8,10,14,15,16,20,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,9,11,12,13,17,18,19,21,22,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1142
uauaugccca agaaagugaa agacca        26


<210>  1143
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  8,10,14,15,16,20,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,9,11,12,13,17,18,19,21,22,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-alk-Me) modification"

<400>  1143
uauaugccca agaaagugaa agacca        26


<210>  1144
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  8,10,14,15,16,20,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,9,11,12,13,17,18,19,21,22,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1144
uauaugccca agaaagugaa agacca        26


<210>  1145
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  15,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,14,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1145
uauaugccca agaaagugaa agacca        26


<210>  1146
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1146
uauaugccca agaaagugaa agacca        26


<210>  1147
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Stearyl) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1147
uauaugccca agaaagugaa agacca        26


<210>  1148
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,7,9,10,13,15,17,19,21,23
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,11,12,14,16,18,20,22,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  5
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1148
auaugcccaa gaaagugaaa gacca         25


<210>  1149
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,9,12,14,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,10,11,13,15,17,19,21,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  4
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1149
uaugcccaag aaagugaaag acca          24


<210>  1150
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (BcN) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1150
uauaugccca agaaagugaa agacca        26


<210>  1151
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1151
uauaugccca agaaagugaa agacca        26


<210>  1152
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Me-alk-SS-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1152
uauaugccca agaaagugaa agacca        26


<210>  1153
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1153
uauaugccca agaaagugaa agacca        26


<210>  1154
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,12,13,15,17,19,21,23
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,14,16,18,20,22
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,5
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1154
augcccaaga aagugaaaga cca           23


<210>  1155
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Norbornene-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1155
uauaugccca agaaagugaa agacca        26


<210>  1156
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-Bc9-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1156
uauaugccca agaaagugaa agacca        26


<210>  1157
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  8,10,14,15,16,20,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,9,11,12,13,17,18,19,21,22,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-Nag3) modification"

<400>  1157
uauaugccca agaaagugaa agacca        26


<210>  1158
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-Ser) modification"

<400>  1158
uauaugccca agaaagugaa agacca        26


<210>  1159
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-Ser)3 modification"

<400>  1159
uauaugccca agaaagugaa agacca        26


<210>  1160
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Norbornene-Ser) modification"

<400>  1160
uauaugccca agaaagugaa agacca        26


<210>  1161
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Norbornene-Ser)3 modification"

<400>  1161
uauaugccca agaaagugaa agacca        26


<210>  1162
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<400>  1162
uauaugccca agaaagugaa agacca        26


<210>  1163
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Norbornene-c6) modification"

<400>  1163
uauaugccca agaaagugaa agacca        26


<210>  1164
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1164
ggagcccaag aaaguga                  17


<210>  1165
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1165
cccaagaaag ugaaaga                  17


<210>  1166
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1166
aagaaaguga aagacca                  17


<210>  1167
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1167
agaaagugaa agaccaa                  17


<210>  1168
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Spermine) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1168
uauaugccca agaaagugaa agacca        26


<210>  1169
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Spermine)2 modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1169
uauaugccca agaaagugaa agacca        26


<210>  1170
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Spermine)3 modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1170
uauaugccca agaaagugaa agacca        26


<210>  1171
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1171
uauaugccca agaaagugaa agacca        26


<210>  1172
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  25, 26
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1172
uauaugccca agaaagugaa agacca        26


<210>  1173
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  5
<223>  /mod_base = "2'-3' seco corresponding nucleotide"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1173
uauaugccca agaaagugaa agacca        26


<210>  1174
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Spermine) modification"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1174
gcccaagaaa gugaaagacc a             21


<210>  1175
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,10,11,13,15,17,19,21
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,12,14,16,18,20
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Spermine)3 modification"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1175
gcccaagaaa gugaaagacc a             21


<210>  1176
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1176
uauaugccca agaaagugaa agacca        26


<210>  1177
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg4-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1177
uauaugccca agaaagugaa agacca        26


<210>  1178
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1178
uauaugccca agaaagugaa agacca        26


<210>  1179
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-PEg4-Nag3) modification"

<400>  1179
uauaugccca agaaagugaa agacca        26


<210>  1180
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (c6-PEg4-Nag3) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1180
uauaugccca agaaagugaa agacca        26


<210>  1181
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1181
uauaugccca agaaagugaa agauau        26


<210>  1182
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-PEg4-Nag3) modification"

<400>  1182
uauaugccca agaaagugaa agauau        26


<210>  1183
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (tetz-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1183
uauaugccca agaaagugaa agacca        26


<210>  1184
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg5-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1184
uauaugccca agaaagugaa agacca        26


<210>  1185
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-NHcO-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1185
uauaugccca agaaagugaa agacca        26


<210>  1186
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-NHcO-SS-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1186
uauaugccca agaaagugaa agacca        26


<210>  1187
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1187
uauaugccca agaaagugaa agacca        26


<210>  1188
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1188
uauaugugcu uugagccuca gcuuca        26


<210>  1189
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6)(NH2-Ser) modification"

<400>  1189
uauaugccca agaaagugaa agacca        26


<210>  1190
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6)(NH2-Ser)2 modification"

<400>  1190
uauaugccca agaaagugaa agacca        26


<210>  1191
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6)(NH2-Ser)3 modification"

<400>  1191
uauaugccca agaaagugaa agacca        26


<210>  1192
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,14,15,17,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1192
uauaugccca agaaagugaa agacca        26


<210>  1193
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,14,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1193
uauaugccca agaaagugaa agacca        26


<210>  1194
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-c12-Nag3) modification"

<400>  1194
uauaugccca agaaagugaa agacca        26


<210>  1195
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-palm-Nag3) modification"

<400>  1195
uauaugccca agaaagugaa agacca        26


<210>  1196
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-c6)(c11-palm-Nag3) modification"

<400>  1196
uauaugccca agaaagugaa agacca        26


<210>  1197
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-palm-Nag3) modification"

<400>  1197
uauaugccca agaaagugaa agauau        26


<210>  1198
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6)(alk-c6-Ser) modification"

<400>  1198
uauaugccca agaaagugaa agacca        26


<210>  1199
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6)(alk-c6-Ser)2 modification"

<400>  1199
uauaugccca agaaagugaa agacca        26


<210>  1200
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6)(alk-c6-Ser)3 modification"

<400>  1200
uauaugccca agaaagugaa agacca        26


<210>  1201
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1201
uauaugccca agaaagugaa agacca        26


<210>  1202
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1202
uauaugccca agaaagugaa agacca        26


<210>  1203
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1203
uauaugccca agaaagugaa agacca        26


<210>  1204
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1204
uaugcccaag aaagugaaag accuau        26


<210>  1205
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-c6-Nag3) modification"

<400>  1205
uauaugccca agaaagugaa agacca        26


<210>  1206
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,12,14,15,16,18,20,22,24,26
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-SS-c6)(c11-PEg3-Nag3) modification"

<400>  1206
uauaugccca agaaagugaa agacca        26


<210>  1207
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  15,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,14,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  25,26
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1207
uauaugccca agaaagugaa agacca        26


<210>  1208
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  15,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,14,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1208
uauaugccca agaaagugaa agacca        26


<210>  1209
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  15,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,14,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-Nag3) modification"

<400>  1209
uauaugccca agaaagugaa agacca        26


<210>  1210
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  15,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,14,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (NH2-c7) modification"

<400>  1210
uauaugccca agaaagugaa agacca        26


<210>  1211
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  15,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,14,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1211
uauaugccca agaaagugaa agacca        26


<210>  1212
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,6,8,9,10,11,12,13,14,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1212
cccaagaaag ugaaaga                  17


<210>  1213
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,8,9,10,11,12,13,14,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1213
cccaagaaag ugaaaga                  17


<210>  1214
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  16/17
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1214
cccaagaaag ugaaaga                  17


<210>  1215
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,16,17
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1215
cccaagaaag ugaaaga                  17


<210>  1216
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1216
cccaagaaag ugaaaga                  17


<210>  1217
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,6,8,9,10,11,12,13,14,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1217
aagaaaguga aagacca                  17


<210>  1218
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,8,9,10,11,12,13,14,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1218
aagaaaguga aagacca                  17


<210>  1219
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  16,17
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1219
aagaaaguga aagacca                  17


<210>  1220
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,16,17
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1220
aagaaaguga aagacca                  17


<210>  1221
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,6,8,10,12,14,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (c11-PEg3-Nag3) modification"

<400>  1221
aagaaaguga aagacca                  17


<210>  1222
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-Ser) modification"

<400>  1222
uauaugccca agaaagugaa agacca        26


<210>  1223
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6)(NH2-Ser) modification"

<400>  1223
uauaugccca agaaagugaa agacca        26


<210>  1224
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6)(NH2-Ser)3 modification"

<400>  1224
uauaugccca agaaagugaa agacca        26


<210>  1225
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-SS-c6) modification"

<400>  1225
uauaugccca agaaagugaa agacca        26


<210>  1226
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6)(alk-c6-Ser) modification"

<400>  1226
uauaugccca agaaagugaa agacca        26


<210>  1227
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6)(alk-c6-Ser)3 modification"

<400>  1227
uauaugccca agaaagugaa agacca        26


<210>  1228
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1228
uauaugccca agaaagugaa agacca        26


<210>  1229
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1229
uauaugccca agaaagugaa agacca        26


<210>  1230
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-Ser) modification"

<400>  1230
uauaugccca agaaagugaa agacca        26


<210>  1231
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-SS-c6) modification"

<400>  1231
uauaugccca agaaagugaa agacca        26


<210>  1232
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1232
uauaugccca agaaagugaa agacca        26


<210>  1233
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,15,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1233
uauaugccca agaaagugaa agacca        26


<210>  1234
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1234
uauaugccca agaaagugaa agacca        26


<210>  1235
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  16,17
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,14,15,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1235
uauaugccca agaaagugaa agacca        26


<210>  1236
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  25,26
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1236
uauaugccca agaaagugaa agacca        26


<210>  1237
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1237
uaugcccaag aaagugaaag accaau        26


<210>  1238
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1238
uaugcccaag aaagugaaag accuau        26


<210>  1239
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1239
uaugcccaag aaagugaaag accuau        26


<210>  1240
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1240
uauaugccca agaaagugaa agacca        26


<210>  1241
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1241
uauaugccca agaaagugaa agacca        26


<210>  1242
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1242
uauaugccca agaaagugaa agacca        26


<210>  1243
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1243
uauaugccca agaaagugaa agacca        26


<210>  1244
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6)(NH2-Ser) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Ser-NH2)(c6-NH2) modification"

<400>  1244
uaugcccaag aaagugaaag accuau        26


<210>  1245
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6)(alk-c6-Ser) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Ser-c6-alk)(c6-c6-alk) modification"

<400>  1245
uaugcccaag aaagugaaag accuau        26


<210>  1246
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1246
uaugcccaag aaagugaaag accuau        26


<210>  1247
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-c6-alk) modification"

<400>  1247
uaugcccaag aaagugaaag accuau        26


<210>  1248
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6,24,25
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1248
uaugcccaag aaagugaaag accuau        26


<210>  1249
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1249
uaugcccaag aaagugaaag accaau        26


<210>  1250
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23,24
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1250
uaugcccaag aaagugaaag accaau        26


<210>  1251
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<400>  1251
uauaugccca agaaagugaa agacca        26


<210>  1252
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6) modification"

<400>  1252
uauaugccca agaaagugaa agacca        26


<210>  1253
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<400>  1253
uauaugccca agaaagugaa agacca        26


<210>  1254
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6) modification"

<400>  1254
uauaugccca agaaagugaa agacca        26


<210>  1255
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg5-Ser) modification"

<400>  1255
uauaugccca agaaagugaa agacca        26


<210>  1256
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg5-c6)(alk-PEg5-Ser) modification"

<400>  1256
uauaugccca agaaagugaa agacca        26


<210>  1257
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg5-Ser) modification"

<400>  1257
uauaugccca agaaagugaa agacca        26


<210>  1258
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg5-c6) modification"

<400>  1258
uauaugccca agaaagugaa agacca        26


<210>  1259
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg5-c6) modification"

<400>  1259
uauaugccca agaaagugaa agacca        26


<210>  1260
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg5-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-PEg5-alk) modification"

<400>  1260
uaugcccaag aaagugaaag accuau        26


<210>  1261
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1261
uauaugccca agaaagugaa agacca        26


<210>  1262
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,26
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1262
uauaugccca agaaagugaa agacca        26


<210>  1263
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1263
uauaugccca agaaagugaa agacca        26


<210>  1264
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1264
uaugcccaag aaagugaaag accuau        26


<210>  1265
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1265
uaugcccaag aaagugaaag accuau        26


<210>  1266
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1266
uaugcccaag aaagugaaag accaau        26


<210>  1267
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1267
uaugcccaag aaagugaaag accauu        26


<210>  1268
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1268
uaugcccaag aaagugaaag accaua        26


<210>  1269
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1269
uaugcccaag aaagugaaag accauu        26


<210>  1270
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1270
uaugcccaag aaagugaaag accaua        26


<210>  1271
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1271
uauaugccca agaaagugaa agacca        26


<210>  1272
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,26
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1272
uauaugccca agaaagugaa agacca        26


<210>  1273
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg13-c6) modification"

<400>  1273
uauaugccca agaaagugaa agacca        26


<210>  1274
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg13-c6)(alk-PEg13-Ser) modification"

<400>  1274
uauaugccca agaaagugaa agacca        26


<210>  1275
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<400>  1275
uuagagccca agaaagugaa agacca        26


<210>  1276
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6) modification"

<400>  1276
uuagagccca agaaagugaa agacca        26


<210>  1277
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<400>  1277
uuauugccca agaaagugaa agacca        26


<210>  1278
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6) modification"

<400>  1278
uuauugccca agaaagugaa agacca        26


<210>  1279
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<400>  1279
uugaugccca agaaagugaa agacca        26


<210>  1280
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  3,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6) modification"

<400>  1280
uugaugccca agaaagugaa agacca        26


<210>  1281
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<400>  1281
uuagagccca agaaagugaa agacca        26


<210>  1282
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6) modification"

<400>  1282
uuagagccca agaaagugaa agacca        26


<210>  1283
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (NH2-c6) modification"

<400>  1283
uaugagccca agaaagugaa agacca        26


<210>  1284
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-c6-c6) modification"

<400>  1284
uaugagccca agaaagugaa agacca        26


<210>  1285
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1285
uauaugccca agaaagugaa agacca        26


<210>  1286
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (c6-NH2) modification"

<400>  1286
uaugcccaag aaagugaaag accuau        26


<210>  1287
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  6,8,10,11,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1287
auagagccca agaaagugaa agacca        26


<210>  1288
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6,8,10,11,14,16,18,20,22,24
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,7,9,12,13,15,17,19,21,23,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (chol-tEg) modification"

<400>  1288
uauaugccca agaaagugaa agacca        26


<210>  1289
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag14) modification"

<400>  1289
uauaugccca agaaagugaa agacca        26


<210>  1290
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  11,13
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,4,5,6,7,8,9,10,12,14,15,16,17,18,19,20,21,22,23,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,5
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1290
augcccaaga aagugaaaga ccuauu        26


<210>  1291
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,24,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  11,13
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,4,5,6,7,8,9,10,12,14,15,16,17,18,19,20,21,22,23,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,5
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1291
augcccaaga aagugaaaga ccugau        26


<210>  1292
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag15) modification"

<400>  1292
uauaugccca agaaagugaa agacca        26


<210>  1293
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag16) modification"

<400>  1293
uauaugccca agaaagugaa agacca        26


<210>  1294
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag17) modification"

<400>  1294
uauaugccca agaaagugaa agacca        26


<210>  1295
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag18) modification"

<400>  1295
uauaugccca agaaagugaa agacca        26


<210>  1296
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag18) modification"

<400>  1296
uauaugccca agaaagugaa agacca        26


<210>  1297
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag18) modification"

<400>  1297
uauaugccca agaaagugaa agacca        26


<210>  1298
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag18) modification"

<400>  1298
uaugcccaag aaagugaaag accuau        26


<210>  1299
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag19) modification"

<400>  1299
uauaugccca agaaagugaa agacca        26


<210>  1300
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag19) modification"

<400>  1300
uauaugccca agaaagugaa agacca        26


<210>  1301
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag19) modification"

<400>  1301
uauaugccca agaaagugaa agacca        26


<210>  1302
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag19) modification"

<400>  1302
uaugcccaag aaagugaaag accuau        26


<210>  1303
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag20) modification"

<400>  1303
uauaugccca agaaagugaa agacca        26


<210>  1304
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag20) modification"

<400>  1304
uauaugccca agaaagugaa agacca        26


<210>  1305
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag20) modification"

<400>  1305
uauaugccca agaaagugaa agacca        26


<210>  1306
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  5,6
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag20) modification"

<400>  1306
uaugcccaag aaagugaaag accuau        26


<210>  1307
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1307
uggucuuuca cuuucuuggg cuauau        26


<210>  1308
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1308
ucuuucacuu ucuuggg                  17


<210>  1309
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1309
acuuucacuu ucuuggg                  17


<210>  1310
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1310
uggucuuuca cuuucuuggg cauuau        26


<210>  1311
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1311
uggucuuuca cuuucuuggg cucaua        26


<210>  1312
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1312
aggucuuuca cuuucuuggg cucuau        26


<210>  1313
<211>  25
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1313
ggucuuucac uuucuugggc ucuau         25


<210>  1314
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1314
ucgucuuuca cuuucuuggg cucuau        26


<210>  1315
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1315
uagucuuuca cuuucuuggg cucuau        26


<210>  1316
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1316
uugucuuuca cuuucuuggg cucuau        26


<210>  1317
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1, 3-26
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1317
atagagccca agaaagugaa agacca        26


<210>  1318
<211>  17
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1318
cccaagaaag ugaaagu                  17


<210>  1319
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1319
gagcccaaga aagugaaaga ccuauu        26


<210>  1320
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1320
gagcccaaga aagugaaaga ccugau        26


<210>  1321
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1321
uauaugccca agaaagugaa agaccu        26


<210>  1322
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1322
uggucuuuca cuuucuuggg cucuau        26


<210>  1323
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,8,9,11,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,4,5,6,7,10,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1323
uggucuuuca cuuucuuggg cucuau        26


<210>  1324
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,9,11,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,10,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1324
uggucuuuca cuuucuuggg cucuau        26


<210>  1325
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,5,8,9,11,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,6,7,10,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1325
uggucuuuca cuuucuuggg cucuau        26


<210>  1326
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,5,9,11,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,6,7,8,10,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1326
uggucuuuca cuuucuuggg cucuau        26


<210>  1327
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,9,11,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,4,5,6,7,8,10,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1327
uggucuuuca cuuucuuggg cucuau        26


<210>  1328
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  23
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1328
uggucuuuca cuuucuuggg cuauau        26


<210>  1329
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  16,17
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  1329
ucuuucacuu ucuugggxx                19


<210>  1330
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,16,17
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  1330
ucuuucacuu ucuugggxx                19


<210>  1331
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,16,17
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end (PaZ) modification"

<400>  1331
ucuuucacuu ucuugggxx                19


<210>  1332
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  1332
acuuucacuu ucuugggxx                19


<210>  1333
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,6,8,12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,7,9,10,11,13,15
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  16,17
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  1333
ucuuucacuu ucuugggxx                19


<210>  1334
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,6,8,12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,7,9,10,11,13,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  1334
acuuucacuu ucuugggxx                19


<210>  1335
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1335
uggucuuuca cuuucuuggg cucuau        26


<210>  1336
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1336
uggucuuuca cuuucuuggg cauuau        26


<210>  1337
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1337
uggucuuuca cuuucuuggg cucaua        26


<210>  1338
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1338
uggucuuuca cuuucuuggg cucuau        26


<210>  1339
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1339
aggucuuuca cuuucuuggg cucuau        26


<210>  1340
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1340
aggucuuuca cuuucuuggg cucuau        26


<210>  1341
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1341  xggucuuuca cuuucuuggg cucuau        26


<210>  1342
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1342  xggucuuuca cuuucuuggg cucuau        26


<210>  1343
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1343
uggucuuuca cuuucuuggg cucuau        26


<210>  1344
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "3'-O-methoxy nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1344
uggucuuuca cuuucuuggg cucuau        26


<210>  1345
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1345
ucgucuuuca cuuucuuggg cucuau        26


<210>  1346
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1346
uagucuuuca cuuucuuggg cucuau        26


<210>  1347
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1347
uugucuuuca cuuucuuggg cucuau        26


<210>  1348
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1348
uggucuuuca cuuucuuggg cucuau        26


<210>  1349
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1349
atagagccca agaaagugaa agacca        26


<210>  1350
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1350
auagagccca agaaagugaa agacca        26


<210>  1351
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,6,8,9,10,11,12,13,14,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1351
cccaagaaag ugaaaga                  17


<210>  1352
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  6,8
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,4,5,7,9,10,11,12,13,14,15,16,17,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  18
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1352  xcccaagaaa gugaaaga                 18


<210>  1353
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  7,9
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,5,6,8,10,11,12,13,14,15,16,17,18,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1353  xxcccaagaa agugaaaga                19


<210>  1354
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,6,8,9,10,11,12,13,14,15
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,16,17
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1354
cccaagaaag ugaaaga                  17


<210>  1355
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,6,8,9,10,11,12,13,14,15
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  16,17
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1355
cccaagaaag ugaaaga                  17


<210>  1356
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,6,8,9,10,11,12,13,14,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1356
cccaagaaag ugaaagu                  17


<210>  1357
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  24
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  11,13
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,12,14,15,16,17,18,19,20,21,22,23,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,5
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1357
gagcccaaga aagugaaaga ccuauu        26


<210>  1358
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  24,25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  11,13
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,12,14,15,16,17,18,19,20,21,22,23,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  4,5
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1358
gagcccaaga aagugaaaga ccugau        26


<210>  1359
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1359
uauaugccca agaaagugaa agacca        26


<210>  1360
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1360
uauaugccca agaaagugaa agacca        26


<210>  1361
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1361
uauaugccca agaaagugaa agacca        26


<210>  1362
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  1362
uauaugccca agaaagugaa agacca        26


<210>  1363
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag21) modification"

<400>  1363
uauaugccca agaaagugaa agacca        26


<210>  1364
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag21) modification"

<400>  1364
uauaugccca agaaagugaa agacca        26


<210>  1365
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag23) modification"

<400>  1365
uauaugccca agaaagugaa agacca        26


<210>  1366
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag23) modification"

<400>  1366
uauaugccca agaaagugaa agacca        26


<210>  1367
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1367
uauaugccca agaaagugaa agacca        26


<210>  1368
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1368
uauaugccca agaaagugaa agacca        26


<210>  1369
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1369
uauaugccca agaaagugaa agacca        26


<210>  1370
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1370
uauaugccca agaaagugaa agacca        26


<210>  1371
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1371
uauaugccca agaaagugaa agacca        26


<210>  1372
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-O-methoxy nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1372
uauaugccca agaaagugaa agacca        26


<210>  1373
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1373
uauaugccca agaaagugaa agaccu        26


<210>  1374
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  1374
uaugagccca agaaagugaa agacca        26


<210>  1375
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1375
cccuggugug cuaccaccc                19


<210>  1376
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1376
ccuggugugc uaccacccc                19


<210>  1377
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1377
cuggugugcu accaccccc                19


<210>  1378
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1378
uuggagccca agaaaguga                19


<210>  1379
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1379
uggagcccaa gaaagugaa                19


<210>  1380
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1380
ggagcccaag aaagugaaa                19


<210>  1381
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1381
gagcccaaga aagugaaag                19


<210>  1382
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1382
agcccaagaa agugaaaga                19


<210>  1383
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1383
gcccaagaaa gugaaagac                19


<210>  1384
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1384
cccaagaaag ugaaagacc                19


<210>  1385
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1385
ccaagaaagu gaaagacca                19


<210>  1386
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1386
caagaaagug aaagaccac                19


<210>  1387
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1387
gugcuuugag ccucagcuu                19


<210>  1388
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1388
ugcuuugagc cucagcuuc                19


<210>  1389
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1389
gcuuugagcc ucagcuucu                19


<210>  1390
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1390
uuugagccuc agcuucucc                19


<210>  1391
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1391
cuggccagcc aggccugcc                19


<210>  1392
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1392
ccaccaguuc gagggggcg                19


<210>  1393
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1393
gggcuguggu gaccgcaac                19


<210>  1394
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1394
ggcuguggug accgcaaca                19


<210>  1395
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1395
gcugugguga ccgcaacaa                19


<210>  1396
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1396
cuguggugac cgcaacaag                19


<210>  1397
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1397
uguggugacc gcaacaagc                19


<210>  1398
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1398
guggugaccg caacaagcc                19


<210>  1399
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1399
uggugaccgc aacaagcca                19


<210>  1400
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1400
gaacucaaua aagugcuuu                19


<210>  1401
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1401
aacucaauaa agugcuuug                19


<210>  1402
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1402
acucaauaaa gugcuuuga                19


<210>  1403
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1403
cucaauaaag ugcuuugaa                19


<210>  1404
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1404
ucaauaaagu gcuuugaaa                19


<210>  1405
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1405
caauaaagug cuuugaaaa                19


<210>  1406
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1406
aauaaagugc uuugaaaau                19


<210>  1407
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1407
gggugguagc acaccaggg                19


<210>  1408
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1408
ggggugguag cacaccagg                19


<210>  1409
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1409
ggggguggua gcacaccag                19


<210>  1410
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1410
ucacuuucuu gggcuccaa                19


<210>  1411
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1411
uucacuuucu ugggcucca                19


<210>  1412
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1412
uuucacuuuc uugggcucc                19


<210>  1413
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1413
cuuucacuuu cuugggcuc                19


<210>  1414
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1414
ucuuucacuu ucuugggcu                19


<210>  1415
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1415
gucuuucacu uucuugggc                19


<210>  1416
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1416
ggucuuucac uuucuuggg                19


<210>  1417
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1417
uggucuuuca cuuucuugg                19


<210>  1418
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1418
guggucuuuc acuuucuug                19


<210>  1419
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1419
aagcugaggc ucaaagcac                19


<210>  1420
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1420
gaagcugagg cucaaagca                19


<210>  1421
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1421
agaagcugag gcucaaagc                19


<210>  1422
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1422
ggagaagcug aggcucaaa                19


<210>  1423
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1423
ggcaggccug gcuggccag                19


<210>  1424
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1424
cgcccccucg aacuggugg                19


<210>  1425
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1425
guugcgguca ccacagccc                19


<210>  1426
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1426
uguugcgguc accacagcc                19


<210>  1427
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1427
uuguugcggu caccacagc                19


<210>  1428
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1428
cuuguugcgg ucaccacag                19


<210>  1429
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1429
gcuuguugcg gucaccaca                19


<210>  1430
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1430
ggcuuguugc ggucaccac                19


<210>  1431
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1431
uggcuuguug cggucacca                19


<210>  1432
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1432
aaagcacuuu auugaguuc                19


<210>  1433
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1433
caaagcacuu uauugaguu                19


<210>  1434
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1434
ucaaagcacu uuauugagu                19


<210>  1435
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1435
uucaaagcac uuuauugag                19


<210>  1436
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1436
uuucaaagca cuuuauuga                19


<210>  1437
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1437
uuuucaaagc acuuuauug                19


<210>  1438
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1438
auuuucaaag cacuuuauu                19


<210>  1439
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1439
cccuggugug cuaccaccat               20


<210>  1440
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1440
ccuggugugc uaccacccat               20


<210>  1441
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1441
cuggugugcu accaccccat               20


<210>  1442
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1442
uuggagccca agaaagugat               20


<210>  1443
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1443
uggagcccaa gaaagugaat               20


<210>  1444
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1444
ggagcccaag aaagugaaat               20


<210>  1445
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1445
gagcccaaga aagugaaaat               20


<210>  1446
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1446
gcccaagaaa gugaaagaat               20


<210>  1447
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1447
gugcuuugag ccucagcuat               20


<210>  1448
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1448
ugcuuugagc cucagcuuat               20


<210>  1449
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1449
gcuuugagcc ucagcuucat               20


<210>  1450
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1450
cuggccagcc aggccugcat               20


<210>  1451
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1451
ccaccaguuc gagggggcat               20


<210>  1452
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1452
gggcuguggu gaccgcaaat               20


<210>  1453
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1453
ggcuguggug accgcaacat               20


<210>  1454
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1454
gcugugguga ccgcaacaat               20


<210>  1455
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1455
cuguggugac cgcaacaaat               20


<210>  1456
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1456
uguggugacc gcaacaagat               20


<210>  1457
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1457
guggugaccg caacaagcat               20


<210>  1458
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1458
uggugaccgc aacaagccat               20


<210>  1459
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1459
gaacucaaua aagugcuuat               20


<210>  1460
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1460
cucaauaaag ugcuuugaat               20


<210>  1461
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1461
ucaauaaagu gcuuugaaat               20


<210>  1462
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1462
caauaaagug cuuugaaaat               20


<210>  1463
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1463
tggugguagc acaccagggt t             21


<210>  1464
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1464
tgggugguag cacaccaggt t             21


<210>  1465
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1465
tgggguggua gcacaccagt t             21


<210>  1466
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1466
tcacuuucuu gggcuccaat t             21


<210>  1467
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1467
tucacuuucu ugggcuccat t             21


<210>  1468
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1468
tuucacuuuc uugggcucct t             21


<210>  1469
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1469
tuuucacuuu cuugggcuct t             21


<210>  1470
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1470
tagcugaggc ucaaagcact t             21


<210>  1471
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1471
taagcugagg cucaaagcat t             21


<210>  1472
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1472
tgaagcugag gcucaaagct t             21


<210>  1473
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1473
tgcaggccug gcuggccagt t             21


<210>  1474
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1474
tgcccccucg aacugguggt t             21


<210>  1475
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1475
tuugcgguca ccacagccct t             21


<210>  1476
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1476
tguugcgguc accacagcct t             21


<210>  1477
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1477
tuguugcggu caccacagct t             21


<210>  1478
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1478
tuuguugcgg ucaccacagt t             21


<210>  1479
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1479
tcuuguugcg gucaccacat t             21


<210>  1480
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1480
tgcuuguugc ggucaccact t             21


<210>  1481
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1481
tggcuuguug cggucaccat t             21


<210>  1482
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1482
taagcacuuu auugaguuct t             21


<210>  1483
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1483
taaagcacuu uauugaguut t             21


<210>  1484
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1484
tcaaagcacu uuauugagut t             21


<210>  1485
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1485
tucaaagcac uuuauugagt t             21


<210>  1486
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1486
tuucaaagca cuuuauugat t             21


<210>  1487
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1487
tuuucaaagc acuuuauugt t             21


<210>  1488
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1488
tuuuucaaag cacuuuauut t             21


<210>  1489
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1489
uggagucaac acuuucgau                19


<210>  1490
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1490
ggagucaaca cuuucgauu                19


<210>  1491
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1491
cccaaggagc auaaguaca                19


<210>  1492
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1492
ccaaggagca uaaguacaa                19


<210>  1493
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1493
caaggagcau aaguacaaa                19


<210>  1494
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1494
agcauaagua caaagcuga                19


<210>  1495
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1495
ugaagagcac acagucguu                19


<210>  1496
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1496
gaagagcaca cagucguuc                19


<210>  1497
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1497
aagagcacac agucguucu                19


<210>  1498
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1498
cacagucguu cucacuguc                19


<210>  1499
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1499
cagucguucu cacugucac                19


<210>  1500
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1500
gcuguaccac aaauguacc                19


<210>  1501
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1501
cuguaccaca aauguaccc                19


<210>  1502
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1502
uguaccacaa auguaccca                19


<210>  1503
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1503
ccacaaaugu acccacaag                19


<210>  1504
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1504
agaugccagu gcaaggguc                19


<210>  1505
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1505
ggggucgcug ccuagaggu                19


<210>  1506
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1506
gcugcuauga uggccgcgg                19


<210>  1507
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1507
cugcuaugau ggccgcggg                19


<210>  1508
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1508
uggccgcggg cucagcuac                19


<210>  1509
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1509
ccgcgggcuc agcuaccgc                19


<210>  1510
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1510
gaccacgcuc ucgggugcg                19


<210>  1511
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1511
accacgcucu cgggugcgc                19


<210>  1512
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1512
ccacgcucuc gggugcgcc                19


<210>  1513
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1513
aagcgcggaa cuggggacu                19


<210>  1514
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1514
ggacugggcg gccacgccu                19


<210>  1515
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1515
gccggaaccc ggacaacga                19


<210>  1516
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1516
cggaacccgg acaacgaca                19


<210>  1517
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1517
ggaacccgga caacgacau                19


<210>  1518
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1518
gaacccggac aacgacauc                19


<210>  1519
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1519
ccggacaacg acauccgcc                19


<210>  1520
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1520
acaacgacau ccgcccgug                19


<210>  1521
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1521
caacgacauc cgcccgugg                19


<210>  1522
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1522
aacgacaucc gcccguggu                19


<210>  1523
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1523
acgacauccg cccguggug                19


<210>  1524
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1524
cauccgcccg uggugcuuc                19


<210>  1525
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1525
auccgcccgu ggugcuucg                19


<210>  1526
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1526
ccgcccgugg ugcuucgug                19


<210>  1527
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1527
gcccguggug cuucgugcu                19


<210>  1528
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1528
cuucaugucc cacucaugc                19


<210>  1529
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1529
gcagccggca ccgccgaag                19


<210>  1530
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1530
ggcuccgcaa gagucuguc                19


<210>  1531
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1531
gcuccgcaag agucugucu                19


<210>  1532
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1532
gagucugucu ucgaugacc                19


<210>  1533
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1533
agucugucuu cgaugaccc                19


<210>  1534
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1534
gucuucgaug acccgcguc                19


<210>  1535
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1535
ucuucgauga cccgcgucg                19


<210>  1536
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1536
cuucgaugac ccgcgucgu                19


<210>  1537
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1537
uucgaugacc cgcgucguu                19


<210>  1538
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1538
ucgaugaccc gcgucguug                19


<210>  1539
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1539
cgaugacccg cgucguugg                19


<210>  1540
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1540
gaugacccgc gucguuggc                19


<210>  1541
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1541
ugacccgcgu cguuggcgg                19


<210>  1542
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1542
gacccgcguc guuggcggg                19


<210>  1543
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1543
gcugguggcg cuacgcggg                19


<210>  1544
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1544
ugguggcgcu acgcggggc                19


<210>  1545
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1545
gguggcgcua cgcggggcg                19


<210>  1546
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1546
guggcgcuac gcggggcgc                19


<210>  1547
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1547
gcuacgcggg gcgcacccc                19


<210>  1548
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1548
ggcgcacccc uacaucgcc                19


<210>  1549
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1549
caccccuaca ucgccgcgc                19


<210>  1550
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1550
ccccuacauc gccgcgcug                19


<210>  1551
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1551
cccuacaucg ccgcgcugu                19


<210>  1552
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1552
ccuacaucgc cgcgcugua                19


<210>  1553
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1553
cuacaucgcc gcgcuguac                19


<210>  1554
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1554
uacaucgccg cgcuguacu                19


<210>  1555
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1555
caucgccgcg cuguacugg                19


<210>  1556
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1556
ucgccgcgcu guacugggg                19


<210>  1557
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1557
cugcgccggc agccucauc                19


<210>  1558
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1558
gcacccgagg aucugacgg                19


<210>  1559
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1559
cacccgagga ucugacggu                19


<210>  1560
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1560
uugcacgagg ccuucucgc                19


<210>  1561
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1561
ugcacgaggc cuucucgcc                19


<210>  1562
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1562
gcacgaccug gcucuguug                19


<210>  1563
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1563
gcucuguugc gccuucagg                19


<210>  1564
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1564
uugcgccuuc aggaggaug                19


<210>  1565
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1565
ggacggcagc ugcgcgcuc                19


<210>  1566
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1566
cgcgcuccug ucgccuuac                19


<210>  1567
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1567
gcgcuccugu cgccuuacg                19


<210>  1568
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1568
cgcuccuguc gccuuacgu                19


<210>  1569
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1569
gcuccugucg ccuuacguu                19


<210>  1570
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1570
cuccugucgc cuuacguuc                19


<210>  1571
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1571
uccugucgcc uuacguuca                19


<210>  1572
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1572
ugucgccuua cguucagcc                19


<210>  1573
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1573
gucgccuuac guucagccg                19


<210>  1574
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1574
ucgccuuacg uucagccgg                19


<210>  1575
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1575
cgccuuacgu ucagccggu                19


<210>  1576
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1576
gccuuacguu cagccggug                19


<210>  1577
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1577
cuuacguuca gccggugug                19


<210>  1578
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1578
acguucagcc ggugugccu                19


<210>  1579
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1579
ggugugccug ccaagcggc                19


<210>  1580
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1580
gccaccaguu cgagggggc                19


<210>  1581
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1581
caccaguucg agggggcgg                19


<210>  1582
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1582
ucgagggggc ggaggaaua                19


<210>  1583
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1583
cugcgcaggg uuccucgag                19


<210>  1584
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1584
ugcgcagggu uccucgagg                19


<210>  1585
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1585
gcgcaggguu ccucgaggg                19


<210>  1586
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1586
uuccucgagg gcggcaccg                19


<210>  1587
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1587
cucgagggcg gcaccgaug                19


<210>  1588
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1588
ucgagggcgg caccgaugc                19


<210>  1589
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1589
cagagcgccg gcucacccu                19


<210>  1590
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1590
aucagcuggg gaucgggcu                19


<210>  1591
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1591
gaucgggcug uggugaccg                19


<210>  1592
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1592
ccgcaacaag ccaggcguc                19


<210>  1593
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1593
gcaacaagcc aggcgucua                19


<210>  1594
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1594
aggcgucuac accgaugug                19


<210>  1595
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1595
ggcgucuaca ccgaugugg                19


<210>  1596
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1596
gcgucuacac cgauguggc                19


<210>  1597
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1597
cuggauccgg gagcacacc                19


<210>  1598
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1598
cugauugcuc agggacuca                19


<210>  1599
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1599
auugcucagg gacucaucu                19


<210>  1600
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1600
aggaacucaa uaaagugcu                19


<210>  1601
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<400>  1601
ggaacucaau aaagugcuu                19


<210>  1602
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1602
aucgaaagug uugacucca                19


<210>  1603
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1603
aaucgaaagu guugacucc                19


<210>  1604
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1604
uguacuuaug cuccuuggg                19


<210>  1605
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1605
uuguacuuau gcuccuugg                19


<210>  1606
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1606
uuuguacuua ugcuccuug                19


<210>  1607
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1607
ucagcuuugu acuuaugcu                19


<210>  1608
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1608
aacgacugug ugcucuuca                19


<210>  1609
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1609
gaacgacugu gugcucuuc                19


<210>  1610
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1610
agaacgacug ugugcucuu                19


<210>  1611
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1611
gacagugaga acgacugug                19


<210>  1612
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1612
gugacaguga gaacgacug                19


<210>  1613
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1613
gguacauuug ugguacagc                19


<210>  1614
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1614
ggguacauuu gugguacag                19


<210>  1615
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1615
uggguacauu ugugguaca                19


<210>  1616
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1616
cuugugggua cauuugugg                19


<210>  1617
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1617
gacccuugca cuggcaucu                19


<210>  1618
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1618
accucuaggc agcgacccc                19


<210>  1619
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1619
ccgcggccau cauagcagc                19


<210>  1620
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1620
cccgcggcca ucauagcag                19


<210>  1621
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1621
guagcugagc ccgcggcca                19


<210>  1622
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1622
gcgguagcug agcccgcgg                19


<210>  1623
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1623
cgcacccgag agcgugguc                19


<210>  1624
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1624
gcgcacccga gagcguggu                19


<210>  1625
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1625
ggcgcacccg agagcgugg                19


<210>  1626
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1626
aguccccagu uccgcgcuu                19


<210>  1627
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1627
aggcguggcc gcccagucc                19


<210>  1628
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1628
ucguuguccg gguuccggc                19


<210>  1629
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1629
ugucguuguc cggguuccg                19


<210>  1630
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1630
augucguugu ccggguucc                19


<210>  1631
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1631
gaugucguug uccggguuc                19


<210>  1632
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1632
ggcggauguc guuguccgg                19


<210>  1633
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1633
cacgggcgga ugucguugu                19


<210>  1634
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1634
ccacgggcgg augucguug                19


<210>  1635
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1635
accacgggcg gaugucguu                19


<210>  1636
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1636
caccacgggc ggaugucgu                19


<210>  1637
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1637
gaagcaccac gggcggaug                19


<210>  1638
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1638
cgaagcacca cgggcggau                19


<210>  1639
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1639
cacgaagcac cacgggcgg                19


<210>  1640
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1640
agcacgaagc accacgggc                19


<210>  1641
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1641
gcaugagugg gacaugaag                19


<210>  1642
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1642
cuucggcggu gccggcugc                19


<210>  1643
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1643
gacagacucu ugcggagcc                19


<210>  1644
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1644
agacagacuc uugcggagc                19


<210>  1645
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1645
ggucaucgaa gacagacuc                19


<210>  1646
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1646
gggucaucga agacagacu                19


<210>  1647
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1647
gacgcggguc aucgaagac                19


<210>  1648
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1648
cgacgcgggu caucgaaga                19


<210>  1649
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1649
acgacgcggg ucaucgaag                19


<210>  1650
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1650
aacgacgcgg gucaucgaa                19


<210>  1651
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1651
caacgacgcg ggucaucga                19


<210>  1652
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1652
ccaacgacgc gggucaucg                19


<210>  1653
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1653
gccaacgacg cgggucauc                19


<210>  1654
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1654
ccgccaacga cgcggguca                19


<210>  1655
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1655
cccgccaacg acgcggguc                19


<210>  1656
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1656
cccgcguagc gccaccagc                19


<210>  1657
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1657
gccccgcgua gcgccacca                19


<210>  1658
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1658
cgccccgcgu agcgccacc                19


<210>  1659
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1659
gcgccccgcg uagcgccac                19


<210>  1660
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1660
ggggugcgcc ccgcguagc                19


<210>  1661
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1661
ggcgauguag gggugcgcc                19


<210>  1662
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1662
gcgcggcgau guaggggug                19


<210>  1663
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1663
cagcgcggcg auguagggg                19


<210>  1664
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1664
acagcgcggc gauguaggg                19


<210>  1665
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1665
uacagcgcgg cgauguagg                19


<210>  1666
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1666
guacagcgcg gcgauguag                19


<210>  1667
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1667
aguacagcgc ggcgaugua                19


<210>  1668
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1668
ccaguacagc gcggcgaug                19


<210>  1669
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1669
ccccaguaca gcgcggcga                19


<210>  1670
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1670
gaugaggcug ccggcgcag                19


<210>  1671
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1671
ccgucagauc cucgggugc                19


<210>  1672
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1672
accgucagau ccucgggug                19


<210>  1673
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1673
gcgagaaggc cucgugcaa                19


<210>  1674
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1674
ggcgagaagg ccucgugca                19


<210>  1675
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1675
caacagagcc aggucgugc                19


<210>  1676
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1676
ccugaaggcg caacagagc                19


<210>  1677
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1677
cauccuccug aaggcgcaa                19


<210>  1678
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1678
gagcgcgcag cugccgucc                19


<210>  1679
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1679
guaaggcgac aggagcgcg                19


<210>  1680
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1680
cguaaggcga caggagcgc                19


<210>  1681
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1681
acguaaggcg acaggagcg                19


<210>  1682
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1682
aacguaaggc gacaggagc                19


<210>  1683
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1683
gaacguaagg cgacaggag                19


<210>  1684
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1684
ugaacguaag gcgacagga                19


<210>  1685
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1685
ggcugaacgu aaggcgaca                19


<210>  1686
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1686
cggcugaacg uaaggcgac                19


<210>  1687
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1687
ccggcugaac guaaggcga                19


<210>  1688
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1688
accggcugaa cguaaggcg                19


<210>  1689
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1689
caccggcuga acguaaggc                19


<210>  1690
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1690
cacaccggcu gaacguaag                19


<210>  1691
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1691
aggcacaccg gcugaacgu                19


<210>  1692
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1692
gccgcuuggc aggcacacc                19


<210>  1693
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1693
gcccccucga acugguggc                19


<210>  1694
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1694
ccgcccccuc gaacuggug                19


<210>  1695
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1695
uauuccuccg cccccucga                19


<210>  1696
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1696
cucgaggaac ccugcgcag                19


<210>  1697
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1697
ccucgaggaa cccugcgca                19


<210>  1698
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1698
cccucgagga acccugcgc                19


<210>  1699
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1699
cggugccgcc cucgaggaa                19


<210>  1700
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1700
caucggugcc gcccucgag                19


<210>  1701
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1701
gcaucggugc cgcccucga                19


<210>  1702
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1702
agggugagcc ggcgcucug                19


<210>  1703
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1703
agcccgaucc ccagcugau                19


<210>  1704
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1704
cggucaccac agcccgauc                19


<210>  1705
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1705
gacgccuggc uuguugcgg                19


<210>  1706
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1706
uagacgccug gcuuguugc                19


<210>  1707
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1707
cacaucggug uagacgccu                19


<210>  1708
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1708
ccacaucggu guagacgcc                19


<210>  1709
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1709
gccacaucgg uguagacgc                19


<210>  1710
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1710
ggugugcucc cggauccag                19


<210>  1711
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1711
ugagucccug agcaaucag                19


<210>  1712
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1712
agaugagucc cugagcaau                19


<210>  1713
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1713
agcacuuuau ugaguuccu                19


<210>  1714
<211>  19
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<400>  1714
aagcacuuua uugaguucc                19


<210>  1715
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1715
uggagucaac acuuucgaat               20


<210>  1716
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1716
ggagucaaca cuuucgauat               20


<210>  1717
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1717
cccaaggagc auaaguacat               20


<210>  1718
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1718
ccaaggagca uaaguacaat               20


<210>  1719
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1719
caaggagcau aaguacaaat               20


<210>  1720
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1720
agcauaagua caaagcugat               20


<210>  1721
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1721
ugaagagcac acagucguat               20


<210>  1722
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1722
gaagagcaca cagucguuat               20


<210>  1723
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1723
aagagcacac agucguucat               20


<210>  1724
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1724
cacagucguu cucacuguat               20


<210>  1725
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1725
cagucguucu cacugucaat               20


<210>  1726
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1726
gcuguaccac aaauguacat               20


<210>  1727
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1727
cuguaccaca aauguaccat               20


<210>  1728
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1728
uguaccacaa auguacccat               20


<210>  1729
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1729
ccacaaaugu acccacaaat               20


<210>  1730
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1730
agaugccagu gcaaggguat               20


<210>  1731
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1731
ggggucgcug ccuagaggat               20


<210>  1732
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1732
gcugcuauga uggccgcgat               20


<210>  1733
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1733
cugcuaugau ggccgcggat               20


<210>  1734
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1734
uggccgcggg cucagcuaat               20


<210>  1735
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1735
ccgcgggcuc agcuaccgat               20


<210>  1736
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1736
gaccacgcuc ucgggugcat               20


<210>  1737
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1737
accacgcucu cgggugcgat               20


<210>  1738
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1738
ccacgcucuc gggugcgcat               20


<210>  1739
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1739
ggacugggcg gccacgccat               20


<210>  1740
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1740
gccggaaccc ggacaacgat               20


<210>  1741
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1741
cggaacccgg acaacgacat               20


<210>  1742
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1742
ggaacccgga caacgacaat               20


<210>  1743
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1743
gaacccggac aacgacauat               20


<210>  1744
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1744
ccggacaacg acauccgcat               20


<210>  1745
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1745
acaacgacau ccgcccguat               20


<210>  1746
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1746
caacgacauc cgcccgugat               20


<210>  1747
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1747
aacgacaucc gcccguggat               20


<210>  1748
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1748
acgacauccg cccgugguat               20


<210>  1749
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1749
cauccgcccg uggugcuuat               20


<210>  1750
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1750
auccgcccgu ggugcuucat               20


<210>  1751
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1751
ccgcccgugg ugcuucguat               20


<210>  1752
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1752
gcccguggug cuucgugcat               20


<210>  1753
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1753
cuucaugucc cacucaugat               20


<210>  1754
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1754
gcagccggca ccgccgaaat               20


<210>  1755
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1755
ggcuccgcaa gagucuguat               20


<210>  1756
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1756
gcuccgcaag agucugucat               20


<210>  1757
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1757
gagucugucu ucgaugacat               20


<210>  1758
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1758
agucugucuu cgaugaccat               20


<210>  1759
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1759
gucuucgaug acccgcguat               20


<210>  1760
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1760
ucuucgauga cccgcgucat               20


<210>  1761
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1761
cuucgaugac ccgcgucgat               20


<210>  1762
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1762
uucgaugacc cgcgucguat               20


<210>  1763
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1763
ucgaugaccc gcgucguuat               20


<210>  1764
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1764
cgaugacccg cgucguugat               20


<210>  1765
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1765
gaugacccgc gucguuggat               20


<210>  1766
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1766
ugacccgcgu cguuggcgat               20


<210>  1767
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1767
gacccgcguc guuggcggat               20


<210>  1768
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1768
gcugguggcg cuacgcggat               20


<210>  1769
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1769
ugguggcgcu acgcggggat               20


<210>  1770
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1770
gguggcgcua cgcggggcat               20


<210>  1771
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1771
guggcgcuac gcggggcgat               20


<210>  1772
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1772
gcuacgcggg gcgcacccat               20


<210>  1773
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1773
ggcgcacccc uacaucgcat               20


<210>  1774
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1774
caccccuaca ucgccgcgat               20


<210>  1775
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1775
ccccuacauc gccgcgcuat               20


<210>  1776
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1776
cccuacaucg ccgcgcugat               20


<210>  1777
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1777
ccuacaucgc cgcgcuguat               20


<210>  1778
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1778
cuacaucgcc gcgcuguaat               20


<210>  1779
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1779
uacaucgccg cgcuguacat               20


<210>  1780
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1780
caucgccgcg cuguacugat               20


<210>  1781
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1781
ucgccgcgcu guacugggat               20


<210>  1782
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1782
cugcgccggc agccucauat               20


<210>  1783
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1783
gcacccgagg aucugacgat               20


<210>  1784
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1784
cacccgagga ucugacggat               20


<210>  1785
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1785
uugcacgagg ccuucucgat               20


<210>  1786
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1786
ugcacgaggc cuucucgcat               20


<210>  1787
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1787
gcacgaccug gcucuguuat               20


<210>  1788
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1788
gcucuguugc gccuucagat               20


<210>  1789
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1789
uugcgccuuc aggaggauat               20


<210>  1790
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1790
ggacggcagc ugcgcgcuat               20


<210>  1791
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1791
cgcgcuccug ucgccuuaat               20


<210>  1792
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1792
gcgcuccugu cgccuuacat               20


<210>  1793
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1793
cgcuccuguc gccuuacgat               20


<210>  1794
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1794
gcuccugucg ccuuacguat               20


<210>  1795
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1795
cuccugucgc cuuacguuat               20


<210>  1796
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1796
uccugucgcc uuacguucat               20


<210>  1797
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1797
ugucgccuua cguucagcat               20


<210>  1798
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1798
gucgccuuac guucagccat               20


<210>  1799
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1799
ucgccuuacg uucagccgat               20


<210>  1800
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1800
cgccuuacgu ucagccggat               20


<210>  1801
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1801
gccuuacguu cagccgguat               20


<210>  1802
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1802
cuuacguuca gccgguguat               20


<210>  1803
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1803
acguucagcc ggugugccat               20


<210>  1804
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1804
ggugugccug ccaagcggat               20


<210>  1805
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1805
gccaccaguu cgagggggat               20


<210>  1806
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1806
caccaguucg agggggcgat               20


<210>  1807
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1807
ucgagggggc ggaggaauat               20


<210>  1808
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1808
cugcgcaggg uuccucgaat               20


<210>  1809
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1809
ugcgcagggu uccucgagat               20


<210>  1810
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1810
gcgcaggguu ccucgaggat               20


<210>  1811
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1811
uuccucgagg gcggcaccat               20


<210>  1812
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1812
cucgagggcg gcaccgauat               20


<210>  1813
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1813
ucgagggcgg caccgaugat               20


<210>  1814
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1814
cagagcgccg gcucacccat               20


<210>  1815
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1815
aucagcuggg gaucgggcat               20


<210>  1816
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1816
gaucgggcug uggugaccat               20


<210>  1817
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1817
ccgcaacaag ccaggcguat               20


<210>  1818
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1818
gcaacaagcc aggcgucuat               20


<210>  1819
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1819
aggcgucuac accgauguat               20


<210>  1820
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1820
ggcgucuaca ccgaugugat               20


<210>  1821
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1821
gcgucuacac cgauguggat               20


<210>  1822
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1822
cuggauccgg gagcacacat               20


<210>  1823
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1823
cugauugcuc agggacucat               20


<210>  1824
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1824
auugcucagg gacucaucat               20


<210>  1825
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1825
aggaacucaa uaaagugcat               20


<210>  1826
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1826
ggaacucaau aaagugcuat               20


<210>  1827
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1827
tucgaaagug uugacuccat t             21


<210>  1828
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1828
taucgaaagu guugacucct t             21


<210>  1829
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1829
tguacuuaug cuccuugggt t             21


<210>  1830
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1830
tuguacuuau gcuccuuggt t             21


<210>  1831
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1831
tuuguacuua ugcuccuugt t             21


<210>  1832
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1832
tcagcuuugu acuuaugcut t             21


<210>  1833
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1833
tacgacugug ugcucuucat t             21


<210>  1834
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1834
taacgacugu gugcucuuct t             21


<210>  1835
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1835
tgaacgacug ugugcucuut t             21


<210>  1836
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1836
tacagugaga acgacugugt t             21


<210>  1837
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1837
tugacaguga gaacgacugt t             21


<210>  1838
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1838
tguacauuug ugguacagct t             21


<210>  1839
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1839
tgguacauuu gugguacagt t             21


<210>  1840
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1840
tggguacauu ugugguacat t             21


<210>  1841
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1841
tuugugggua cauuuguggt t             21


<210>  1842
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1842
tacccuugca cuggcaucut t             21


<210>  1843
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1843
tccucuaggc agcgacccct t             21


<210>  1844
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1844
tcgcggccau cauagcagct t             21


<210>  1845
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1845
tccgcggcca ucauagcagt t             21


<210>  1846
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1846
tuagcugagc ccgcggccat t             21


<210>  1847
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1847
tcgguagcug agcccgcggt t             21


<210>  1848
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1848
tgcacccgag agcgugguct t             21


<210>  1849
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1849
tcgcacccga gagcguggut t             21


<210>  1850
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1850
tgcgcacccg agagcguggt t             21


<210>  1851
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1851
tguccccagu uccgcgcuut t             21


<210>  1852
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1852
tggcguggcc gcccagucct t             21


<210>  1853
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1853
tcguuguccg gguuccggct t             21


<210>  1854
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1854
tgucguuguc cggguuccgt t             21


<210>  1855
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1855
tugucguugu ccggguucct t             21


<210>  1856
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1856
taugucguug uccggguuct t             21


<210>  1857
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1857
tgcggauguc guuguccggt t             21


<210>  1858
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1858
tacgggcgga ugucguugut t             21


<210>  1859
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1859
tcacgggcgg augucguugt t             21


<210>  1860
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1860
tccacgggcg gaugucguut t             21


<210>  1861
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1861
taccacgggc ggaugucgut t             21


<210>  1862
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1862
taagcaccac gggcggaugt t             21


<210>  1863
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1863
tgaagcacca cgggcggaut t             21


<210>  1864
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1864
tacgaagcac cacgggcggt t             21


<210>  1865
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1865
tgcacgaagc accacgggct t             21


<210>  1866
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1866
tcaugagugg gacaugaagt t             21


<210>  1867
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1867
tuucggcggu gccggcugct t             21


<210>  1868
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1868
tacagacucu ugcggagcct t             21


<210>  1869
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1869
tgacagacuc uugcggagct t             21


<210>  1870
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1870
tgucaucgaa gacagacuct t             21


<210>  1871
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1871
tggucaucga agacagacut t             21


<210>  1872
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1872
tacgcggguc aucgaagact t             21


<210>  1873
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1873
tgacgcgggu caucgaagat t             21


<210>  1874
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1874
tcgacgcggg ucaucgaagt t             21


<210>  1875
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1875
tacgacgcgg gucaucgaat t             21


<210>  1876
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1876
taacgacgcg ggucaucgat t             21


<210>  1877
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1877
tcaacgacgc gggucaucgt t             21


<210>  1878
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1878
tccaacgacg cgggucauct t             21


<210>  1879
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1879
tcgccaacga cgcgggucat t             21


<210>  1880
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1880
tccgccaacg acgcggguct t             21


<210>  1881
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1881
tccgcguagc gccaccagct t             21


<210>  1882
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1882
tccccgcgua gcgccaccat t             21


<210>  1883
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1883
tgccccgcgu agcgccacct t             21


<210>  1884
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1884
tcgccccgcg uagcgccact t             21


<210>  1885
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1885
tgggugcgcc ccgcguagct t             21


<210>  1886
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1886
tgcgauguag gggugcgcct t             21


<210>  1887
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1887
tcgcggcgau guaggggugt t             21


<210>  1888
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1888
tagcgcggcg auguaggggt t             21


<210>  1889
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1889
tcagcgcggc gauguagggt t             21


<210>  1890
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1890
tacagcgcgg cgauguaggt t             21


<210>  1891
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1891
tuacagcgcg gcgauguagt t             21


<210>  1892
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1892
tguacagcgc ggcgauguat t             21


<210>  1893
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1893
tcaguacagc gcggcgaugt t             21


<210>  1894
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1894
tcccaguaca gcgcggcgat t             21


<210>  1895
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1895
taugaggcug ccggcgcagt t             21


<210>  1896
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1896
tcgucagauc cucgggugct t             21


<210>  1897
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1897
tccgucagau ccucgggugt t             21


<210>  1898
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1898
tcgagaaggc cucgugcaat t             21


<210>  1899
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1899
tgcgagaagg ccucgugcat t             21


<210>  1900
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1900
taacagagcc aggucgugct t             21


<210>  1901
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1901
tcugaaggcg caacagagct t             21


<210>  1902
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1902
tauccuccug aaggcgcaat t             21


<210>  1903
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1903
tagcgcgcag cugccgucct t             21


<210>  1904
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1904
tuaaggcgac aggagcgcgt t             21


<210>  1905
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1905
tguaaggcga caggagcgct t             21


<210>  1906
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1906
tcguaaggcg acaggagcgt t             21


<210>  1907
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1907
tacguaaggc gacaggagct t             21


<210>  1908
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1908
taacguaagg cgacaggagt t             21


<210>  1909
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1909
tgaacguaag gcgacaggat t             21


<210>  1910
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1910
tgcugaacgu aaggcgacat t             21


<210>  1911
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1911
tggcugaacg uaaggcgact t             21


<210>  1912
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1912
tcggcugaac guaaggcgat t             21


<210>  1913
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1913
tccggcugaa cguaaggcgt t             21


<210>  1914
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1914
taccggcuga acguaaggct t             21


<210>  1915
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1915
tacaccggcu gaacguaagt t             21


<210>  1916
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1916
tggcacaccg gcugaacgut t             21


<210>  1917
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1917
tccgcuuggc aggcacacct t             21


<210>  1918
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1918
tcccccucga acugguggct t             21


<210>  1919
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1919
tcgcccccuc gaacuggugt t             21


<210>  1920
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1920
tauuccuccg cccccucgat t             21


<210>  1921
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1921
tucgaggaac ccugcgcagt t             21


<210>  1922
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1922
tcucgaggaa cccugcgcat t             21


<210>  1923
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1923
tccucgagga acccugcgct t             21


<210>  1924
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1924
tggugccgcc cucgaggaat t             21


<210>  1925
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1925
taucggugcc gcccucgagt t             21


<210>  1926
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1926
tcaucggugc cgcccucgat t             21


<210>  1927
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1927
tgggugagcc ggcgcucugt t             21


<210>  1928
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1928
tgcccgaucc ccagcugaut t             21


<210>  1929
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1929
tggucaccac agcccgauct t             21


<210>  1930
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1930
tacgccuggc uuguugcggt t             21


<210>  1931
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1931
tagacgccug gcuuguugct t             21


<210>  1932
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1932
tacaucggug uagacgccut t             21


<210>  1933
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1933
tcacaucggu guagacgcct t             21


<210>  1934
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1934
tccacaucgg uguagacgct t             21


<210>  1935
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1935
tgugugcucc cggauccagt t             21


<210>  1936
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1936
tgagucccug agcaaucagt t             21


<210>  1937
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1937
tgaugagucc cugagcaaut t             21


<210>  1938
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1938
tgcacuuuau ugaguuccut t             21


<210>  1939
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2-19
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  1939
tagcacuuua uugaguucct t             21


<210>  1940
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1940
uggagucaac acuuucgaat               20


<210>  1941
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1941
ggagucaaca cuuucgauat               20


<210>  1942
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1942
cccaaggagc auaaguacat               20


<210>  1943
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1943
ccaaggagca uaaguacaat               20


<210>  1944
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1944
caaggagcau aaguacaaat               20


<210>  1945
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1945
agcauaagua caaagcugat               20


<210>  1946
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1946
ugaagagcac acagucguat               20


<210>  1947
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1947
gaagagcaca cagucguuat               20


<210>  1948
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1948
aagagcacac agucguucat               20


<210>  1949
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1949
cacagucguu cucacuguat               20


<210>  1950
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1950
cagucguucu cacugucaat               20


<210>  1951
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1951
gcuguaccac aaauguacat               20


<210>  1952
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1952
cuguaccaca aauguaccat               20


<210>  1953
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1953
uguaccacaa auguacccat               20


<210>  1954
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1954
ccacaaaugu acccacaaat               20


<210>  1955
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1955
agaugccagu gcaaggguat               20


<210>  1956
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1956
ggggucgcug ccuagaggat               20


<210>  1957
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1957
gcugcuauga uggccgcgat               20


<210>  1958
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1958
cugcuaugau ggccgcggat               20


<210>  1959
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1959
uggccgcggg cucagcuaat               20


<210>  1960
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1960
ccgcgggcuc agcuaccgat               20


<210>  1961
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1961
gaccacgcuc ucgggugcat               20


<210>  1962
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1962
accacgcucu cgggugcgat               20


<210>  1963
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1963
ccacgcucuc gggugcgcat               20


<210>  1964
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1964
aagcgcggaa cuggggacat               20


<210>  1965
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1965
ggacugggcg gccacgccat               20


<210>  1966
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1966
gccggaaccc ggacaacgat               20


<210>  1967
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1967
cggaacccgg acaacgacat               20


<210>  1968
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1968
ggaacccgga caacgacaat               20


<210>  1969
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1969
gaacccggac aacgacauat               20


<210>  1970
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1970
ccggacaacg acauccgcat               20


<210>  1971
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1971
acaacgacau ccgcccguat               20


<210>  1972
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1972
caacgacauc cgcccgugat               20


<210>  1973
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1973
aacgacaucc gcccguggat               20


<210>  1974
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1974
acgacauccg cccgugguat               20


<210>  1975
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1975
cauccgcccg uggugcuuat               20


<210>  1976
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1976
auccgcccgu ggugcuucat               20


<210>  1977
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1977
ccgcccgugg ugcuucguat               20


<210>  1978
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1978
gcccguggug cuucgugcat               20


<210>  1979
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1979
cuucaugucc cacucaugat               20


<210>  1980
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1980
gcagccggca ccgccgaaat               20


<210>  1981
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1981
ggcuccgcaa gagucuguat               20


<210>  1982
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1982
gcuccgcaag agucugucat               20


<210>  1983
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1983
gagucugucu ucgaugacat               20


<210>  1984
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1984
agucugucuu cgaugaccat               20


<210>  1985
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1985
gucuucgaug acccgcguat               20


<210>  1986
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1986
ucuucgauga cccgcgucat               20


<210>  1987
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1987
cuucgaugac ccgcgucgat               20


<210>  1988
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1988
uucgaugacc cgcgucguat               20


<210>  1989
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1989
ucgaugaccc gcgucguuat               20


<210>  1990
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1990
cgaugacccg cgucguugat               20


<210>  1991
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1991
gaugacccgc gucguuggat               20


<210>  1992
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1992
ugacccgcgu cguuggcgat               20


<210>  1993
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1993
gacccgcguc guuggcggat               20


<210>  1994
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1994
gcugguggcg cuacgcggat               20


<210>  1995
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1995
ugguggcgcu acgcggggat               20


<210>  1996
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1996
gguggcgcua cgcggggcat               20


<210>  1997
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1997
guggcgcuac gcggggcgat               20


<210>  1998
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1998
gcuacgcggg gcgcacccat               20


<210>  1999
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  1999
ggcgcacccc uacaucgcat               20


<210>  2000
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2000
caccccuaca ucgccgcgat               20


<210>  2001
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2001
ccccuacauc gccgcgcuat               20


<210>  2002
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2002
cccuacaucg ccgcgcugat               20


<210>  2003
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2003
ccuacaucgc cgcgcuguat               20


<210>  2004
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2004
cuacaucgcc gcgcuguaat               20


<210>  2005
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2005
uacaucgccg cgcuguacat               20


<210>  2006
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2006
caucgccgcg cuguacugat               20


<210>  2007
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2007
ucgccgcgcu guacugggat               20


<210>  2008
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2008
cugcgccggc agccucauat               20


<210>  2009
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2009
gcacccgagg aucugacgat               20


<210>  2010
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2010
cacccgagga ucugacggat               20


<210>  2011
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2011
uugcacgagg ccuucucgat               20


<210>  2012
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2012
ugcacgaggc cuucucgcat               20


<210>  2013
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2013
gcacgaccug gcucuguuat               20


<210>  2014
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2014
gcucuguugc gccuucagat               20


<210>  2015
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2015
uugcgccuuc aggaggauat               20


<210>  2016
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2016
ggacggcagc ugcgcgcuat               20


<210>  2017
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2017
cgcgcuccug ucgccuuaat               20


<210>  2018
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2018
gcgcuccugu cgccuuacat               20


<210>  2019
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2019
cgcuccuguc gccuuacgat               20


<210>  2020
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2020
gcuccugucg ccuuacguat               20


<210>  2021
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2021
cuccugucgc cuuacguuat               20


<210>  2022
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2022
uccugucgcc uuacguucat               20


<210>  2023
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2023
ugucgccuua cguucagcat               20


<210>  2024
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2024
gucgccuuac guucagccat               20


<210>  2025
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2025
ucgccuuacg uucagccgat               20


<210>  2026
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2026
cgccuuacgu ucagccggat               20


<210>  2027
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2027
gccuuacguu cagccgguat               20


<210>  2028
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2028
cuuacguuca gccgguguat               20


<210>  2029
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2029
acguucagcc ggugugccat               20


<210>  2030
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2030
ggugugccug ccaagcggat               20


<210>  2031
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2031
gccaccaguu cgagggggat               20


<210>  2032
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2032
caccaguucg agggggcgat               20


<210>  2033
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2033
ucgagggggc ggaggaauat               20


<210>  2034
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2034
cugcgcaggg uuccucgaat               20


<210>  2035
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2035
ugcgcagggu uccucgagat               20


<210>  2036
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2036
gcgcaggguu ccucgaggat               20


<210>  2037
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2037
uuccucgagg gcggcaccat               20


<210>  2038
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2038
cucgagggcg gcaccgauat               20


<210>  2039
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2039
ucgagggcgg caccgaugat               20


<210>  2040
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2040
cagagcgccg gcucacccat               20


<210>  2041
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2041
aucagcuggg gaucgggcat               20


<210>  2042
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2042
gaucgggcug uggugaccat               20


<210>  2043
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2043
ccgcaacaag ccaggcguat               20


<210>  2044
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2044
gcaacaagcc aggcgucuat               20


<210>  2045
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2045
aggcgucuac accgauguat               20


<210>  2046
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2046
ggcgucuaca ccgaugugat               20


<210>  2047
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2047
gcgucuacac cgauguggat               20


<210>  2048
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2048
cuggauccgg gagcacacat               20


<210>  2049
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2049
cugauugcuc agggacucat               20


<210>  2050
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2050
auugcucagg gacucaucat               20


<210>  2051
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2051
aggaacucaa uaaagugcat               20


<210>  2052
<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNAi agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<400>  2052
ggaacucaau aaagugcuat               20


<210>  2053
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2053
tucgaaagug uugacuccat t             21


<210>  2054
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2054
taucgaaagu guugacucct t             21


<210>  2055
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2055
tguacuuaug cuccuugggt t             21


<210>  2056
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2056
tuguacuuau gcuccuuggt t             21


<210>  2057
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2057
tuuguacuua ugcuccuugt t             21


<210>  2058
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2058
tcagcuuugu acuuaugcut t             21


<210>  2059
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2059
tacgacugug ugcucuucat t             21


<210>  2060
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2060
taacgacugu gugcucuuct t             21


<210>  2061
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2061
tgaacgacug ugugcucuut t             21


<210>  2062
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2062
tacagugaga acgacugugt t             21


<210>  2063
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2063
tugacaguga gaacgacugt t             21


<210>  2064
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2064
tguacauuug ugguacagct t             21


<210>  2065
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2065
tgguacauuu gugguacagt t             21


<210>  2066
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2066
tggguacauu ugugguacat t             21


<210>  2067
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2067
tuugugggua cauuuguggt t             21


<210>  2068
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2068
tacccuugca cuggcaucut t             21


<210>  2069
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2069
tccucuaggc agcgacccct t             21


<210>  2070
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2070
tcgcggccau cauagcagct t             21


<210>  2071
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2071
tccgcggcca ucauagcagt t             21


<210>  2072
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2072
tuagcugagc ccgcggccat t             21


<210>  2073
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2073
tcgguagcug agcccgcggt t             21


<210>  2074
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2074
tgcacccgag agcgugguct t             21


<210>  2075
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2075
tcgcacccga gagcguggut t             21


<210>  2076
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2076
tgcgcacccg agagcguggt t             21


<210>  2077
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2077
tguccccagu uccgcgcuut t             21


<210>  2078
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2078
tggcguggcc gcccagucct t             21


<210>  2079
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2079
tcguuguccg gguuccggct t             21


<210>  2080
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2080
tgucguuguc cggguuccgt t             21


<210>  2081
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2081
tugucguugu ccggguucct t             21


<210>  2082
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNAi agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2082
taugucguug uccggguuct t             21


<210>  2083
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2083
tgcggauguc guuguccggt t             21


<210>  2084
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2084
tacgggcgga ugucguugut t             21


<210>  2085
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2085
tcacgggcgg augucguugt t             21


<210>  2086
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2086
tccacgggcg gaugucguut t             21


<210>  2087
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2087
taccacgggc ggaugucgut t             21


<210>  2088
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2088
taagcaccac gggcggaugt t             21


<210>  2089
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2089
tgaagcacca cgggcggaut t             21


<210>  2090
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2090
tacgaagcac cacgggcggt t             21


<210>  2091
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2091
tgcacgaagc accacgggct t             21


<210>  2092
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2092
tcaugagugg gacaugaagt t             21


<210>  2093
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2093
tuucggcggu gccggcugct t             21


<210>  2094
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2094
tacagacucu ugcggagcct t             21


<210>  2095
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2095
tgacagacuc uugcggagct t             21


<210>  2096
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2096
tgucaucgaa gacagacuct t             21


<210>  2097
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2097
tggucaucga agacagacut t             21


<210>  2098
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2098
tacgcggguc aucgaagact t             21


<210>  2099
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2099
tgacgcgggu caucgaagat t             21


<210>  2100
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2100
tcgacgcggg ucaucgaagt t             21


<210>  2101
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2101
tacgacgcgg gucaucgaat t             21


<210>  2102
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2102
taacgacgcg ggucaucgat t             21


<210>  2103
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2103
tcaacgacgc gggucaucgt t             21


<210>  2104
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2104
tccaacgacg cgggucauct t             21


<210>  2105
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2105
tcgccaacga cgcgggucat t             21


<210>  2106
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2106
tccgccaacg acgcggguct t             21


<210>  2107
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2107
tccgcguagc gccaccagct t             21


<210>  2108
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2108
tccccgcgua gcgccaccat t             21


<210>  2109
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2109
tgccccgcgu agcgccacct t             21


<210>  2110
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2110
tcgccccgcg uagcgccact t             21


<210>  2111
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2111
tgggugcgcc ccgcguagct t             21


<210>  2112
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2112
tgcgauguag gggugcgcct t             21


<210>  2113
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2113
tcgcggcgau guaggggugt t             21


<210>  2114
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2114
tagcgcggcg auguaggggt t             21


<210>  2115
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2115
tcagcgcggc gauguagggt t             21


<210>  2116
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2116
tacagcgcgg cgauguaggt t             21


<210>  2117
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2117
tuacagcgcg gcgauguagt t             21


<210>  2118
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2118
tguacagcgc ggcgauguat t             21


<210>  2119
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2119
tcaguacagc gcggcgaugt t             21


<210>  2120
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2120
tcccaguaca gcgcggcgat t             21


<210>  2121
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2121
taugaggcug ccggcgcagt t             21


<210>  2122
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2122
tcgucagauc cucgggugct t             21


<210>  2123
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2123
tccgucagau ccucgggugt t             21


<210>  2124
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2124
tcgagaaggc cucgugcaat t             21


<210>  2125
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2125
tgcgagaagg ccucgugcat t             21


<210>  2126
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2126
taacagagcc aggucgugct t             21


<210>  2127
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2127
tcugaaggcg caacagagct t             21


<210>  2128
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2128
tauccuccug aaggcgcaat t             21


<210>  2129
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2129
tagcgcgcag cugccgucct t             21


<210>  2130
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2130
tuaaggcgac aggagcgcgt t             21


<210>  2131
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2131
tguaaggcga caggagcgct t             21


<210>  2132
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2132
tcguaaggcg acaggagcgt t             21


<210>  2133
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2133
tacguaaggc gacaggagct t             21


<210>  2134
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2134
taacguaagg cgacaggagt t             21


<210>  2135
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2135
tgaacguaag gcgacaggat t             21


<210>  2136
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2136
tgcugaacgu aaggcgacat t             21


<210>  2137
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2137
tggcugaacg uaaggcgact t             21


<210>  2138
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2138
tcggcugaac guaaggcgat t             21


<210>  2139
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2139
tccggcugaa cguaaggcgt t             21


<210>  2140
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2140
taccggcuga acguaaggct t             21


<210>  2141
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2141
tacaccggcu gaacguaagt t             21


<210>  2142
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2142
tggcacaccg gcugaacgut t             21


<210>  2143
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2143
tccgcuuggc aggcacacct t             21


<210>  2144
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2144
tcccccucga acugguggct t             21


<210>  2145
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2145
tcgcccccuc gaacuggugt t             21


<210>  2146
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2146
tauuccuccg cccccucgat t             21


<210>  2147
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2147
tucgaggaac ccugcgcagt t             21


<210>  2148
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2148
tcucgaggaa cccugcgcat t             21


<210>  2149
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2149
tccucgagga acccugcgct t             21


<210>  2150
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2150
tggugccgcc cucgaggaat t             21


<210>  2151
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2151
taucggugcc gcccucgagt t             21


<210>  2152
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2152
tcaucggugc cgcccucgat t             21


<210>  2153
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2153
tgggugagcc ggcgcucugt t             21


<210>  2154
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2154
tgcccgaucc ccagcugaut t             21


<210>  2155
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2155
tggucaccac agcccgauct t             21


<210>  2156
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2156
tacgccuggc uuguugcggt t             21


<210>  2157
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2157
tagacgccug gcuuguugct t             21


<210>  2158
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2158
tacaucggug uagacgccut t             21


<210>  2159
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2159
tcacaucggu guagacgcct t             21


<210>  2160
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2160
tccacaucgg uguagacgct t             21


<210>  2161
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2161
tgugugcucc cggauccagt t             21


<210>  2162
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2162
tgagucccug agcaaucagt t             21


<210>  2163
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2163
tgaugagucc cugagcaaut t             21


<210>  2164
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2164
tgcacuuuau ugaguuccut t             21


<210>  2165
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16,18
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,5,7,9,11,13,15,17,19
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  21
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2165
tagcacuuua uugaguucct t             21


<210>  2166
<211>  20
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<400>  2166
gcccaagaaa gugaaagacc               20


<210>  2167
<211>  20
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<400>  2167
gcuuugagcc ucagcuucuc               20


<210>  2168
<211>  20
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<400>  2168
agcccaagaa agugaaagac               20


<210>  2169
<211>  20
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<400>  2169
ggagcccaag aaagugaaag               20


<210>  2170
<211>  20
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<400>  2170
gagcccaaga aagugaaaga               20


<210>  2171
<211>  20
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<400>  2171
cccaagaaag ugaaagacca               20


<210>  2172
<211>  22
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<400>  2172
ggucuuucac uuucuugggc uc            22


<210>  2173
<211>  22
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<400>  2173
gagaagcuga ggcucaaagc ac            22


<210>  2174
<211>  22
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<400>  2174
gucuuucacu uucuugggcu cc            22


<210>  2175
<211>  22
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<400>  2175
cuuucacuuu cuugggcucc aa            22


<210>  2176
<211>  22
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<400>  2176
ucuuucacuu ucuugggcuc ca            22


<210>  2177
<211>  22
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<400>  2177
uggucuuuca cuuucuuggg cu            22


<210>  2178
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<400>  2178
uggucuuuca cuuucuuggg cucagu        26


<210>  2179
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<400>  2179
uggucuuuca cuuucuuggg cuccaa        26


<210>  2180
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<400>  2180
uggucuuuca cuuucuuggg cuccag        26


<210>  2181
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<400>  2181
uggucuuuca cuuucuuggg cucgcg        26


<210>  2182
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  1-25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<400>  2182
uggucuuuca cuuucuuggg cucuat        26


<210>  2183
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<400>  2183
gacaugccca agaaagugaa agacca        26


<210>  2184
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<400>  2184
gcgaugccca agaaagugaa agacca        26


<210>  2185
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<400>  2185
ugaaugccca agaaagugaa agacca        26


<210>  2186
<211>  26
<212>  RNa
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<400>  2186
uuggagccca agaaagugaa agacca        26


<210>  2187
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (SO3) modification"

<400>  2187
uggucuuuca cuuucuuggg cucuau        26


<210>  2188
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2188
uggucuuuca cuuucuuggg cuccag        26


<210>  2189
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2189
uggucuuuca cuuucuuggg cucagu        26


<210>  2190
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2190
uggucuuuca cuuucuuggg cucgcg        26


<210>  2191
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2191
uggucuuuca cuuucuuggg cuccaa        26


<210>  2192
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  2192
ucuuucacuu ucuugggxx                19


<210>  2193
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  2193
ucuuucacuu ucuugggxx                19


<210>  2194
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  16,17
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  2194
ucuuucacuu ucuugggxx                19


<210>  2195
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "2'-F-arabino nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2195
uggucuuuca cuuucuuggg cucuau        26


<210>  2196
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  8
<223>  /mod_base = "2'-F-arabino nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2196
uggucuuuca cuuucuuggg cucuau        26


<210>  2197
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,8,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  10
<223>  /mod_base = "2'-F-arabino nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2197
uggucuuuca cuuucuuggg cucuau        26


<210>  2198
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,8,10
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  14
<223>  /mod_base = "2'-F-arabino nucleotide"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2198
uggucuuuca cuuucuuggg cucuau        26


<210>  2199
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  18,19
<223>  /mod_base = "abasic corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,18
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  19
<223>  /mod_base = "3' end thioate(PaZ) modification"

<400>  2199
ucuuucacuu ucuugggxx                19


<210>  2200
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end thioate(c12)s(PaZ) modification"

<400>  2200
ucuuucacuu ucuuggg                  17


<210>  2201
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2201
uggucuuuca cuuucuuggg cucuau        26


<210>  2202
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2202
uggucuuuca cuuucuuggg cucuau        26


<210>  2203
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  25,26
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2203
uggucuuuca cuuucuuggg cucuat        26


<210>  2204
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  25,26
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3,25,26
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2204
uggucuuuca cuuucuuggg cucuat        26


<210>  2205
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  antisense strand of an RNai agent

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-hydroxy corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,8,10,14
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,5,6,7,9,11,12,13,15,16,17,18,19,20,21,22,23,24,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,22,23
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<400>  2205
tggucuuuca cuuucuuggg cucuau        26


<210>  2206
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2206
gacaugccca agaaagugaa agacca        26


<210>  2207
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2207
ugaaugccca agaaagugaa agacca        26


<210>  2208
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2208
gcgaugccca agaaagugaa agacca        26


<210>  2209
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2209
uaugagccca agaaagugaa agacca        26


<210>  2210
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2210
uuggagccca agaaagugaa agacca        26


<210>  2211
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,6,8,9,10,11,12,13,14,15,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2211
cccaagaaag ugaaaga                  17


<210>  2212
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,6,8,9,10,11,12,13,14,15,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  16
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2212
cccaagaaag ugaaaga                  17


<210>  2213
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,3,4,6,8,9,10,11,12,13,14,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  2
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2213
cccaagaaag ugaaaga                  17


<210>  2214
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,4,6,8,9,10,11,12,13,14,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2214
cccaagaaag ugaaaga                  17


<210>  2215
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,6,8,9,10,11,12,13,14,15
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  16,17
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2215
cccaagaaag ugaaaga                  17


<210>  2216
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  3,4,6,8,9,10,11,12,13,14,15,16,17
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2216
cccaagaaag ugaaaga                  17


<210>  2217
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  5,7
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,3,4,6,8,9,10,11,12,13,14,15,16
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,17
<223>  /mod_base = "locked nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2217
cccaagaaag ugaaaga                  17


<210>  2218
<211>  17
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  1,3,5,7,9,11,13,15
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  2,4,6,8,10,12,14
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  16,17
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  2,3
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  17
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2218
cccaagaaag ugaaaga                  17


<210>  2219
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag18) modification"

<400>  2219
uaugagccca agaaagugaa agacca        26


<210>  2220
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag18) modification"

<400>  2220
auagagccca agaaagugaa agacca        26


<210>  2221
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag18) modification"

<400>  2221
gacaugccca agaaagugaa agacca        26


<210>  2222
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag18) modification"

<400>  2222
ugaaugccca agaaagugaa agacca        26


<210>  2223
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag18) modification"

<400>  2223
gcgaugccca agaaagugaa agacca        26


<210>  2224
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag18) modification"

<400>  2224
uauaugccca agaaagugaa agacca        26


<210>  2225
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  25
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag18) modification"

<400>  2225
uauaugccca agaaagugaa agacca        26


<210>  2226
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3'-3'-linked nucleotide"

<220>
<221>  modified_base
<222>  24,25
<223>  /mod_base = "2'-MOE nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (Nag18) modification"

<400>  2226
uauaugccca agaaagugaa agacca        26


<210>  2227
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  sense strand of an RNai agent

<220>
<221>  modified_base
<222>  14,16
<223>  /mod_base = "2'-deoxy-2'-fluoro corresponding nucleoside"

<220>
<221>  modified_base
<222>  1,2,3,4,5,6,7,8,9,10,11,12,13,15,17,18,19,20,21,22,23,24,25,26
<223>  /mod_base = "2'-O-methyl corresponding nucleoside"

<220>
<221>  modified_base
<222>  7,8
<223>  /mod_base = "5'-phosphorothioate corresponding nucleotide"

<220>
<221>  modified_base
<222>  1
<223>  /mod_base = "5' end (alk-PEg4-c6) modification"

<220>
<221>  modified_base
<222>  26
<223>  /mod_base = "3' end (Nag13) modification"

<400>  2227
uauaugccca agaaagugaa agacca        26


<210>  2228
<211>  26
<212>  PRT
<213>  Apis florea

<400>  2228

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2229
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2229

Ala Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     

<210>  2230
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>    

<400>  2230

Cys Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2231
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2231

Phe Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2232
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2232

His Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2233
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2233

Ile Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2234
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2234
Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2235
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<220>  
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle

<400>  2235

Xaa Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2236
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2236

Val Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2237
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2237

Trp Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2238
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2238

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2239
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D-form Apis florea melittin sequence

<400>  2239

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2240
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2240

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Leu Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2241
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2241

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Trp Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2242
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2242

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Thr Lys Arg Lys Gln 
            20                  25     


<210>  2243
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2243

Tyr Ile Gly Ala Ile Leu Asn Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2244
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2244

Tyr Ile Gly Ala Ile Leu Ala Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2245
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2245

Leu Ile Gly Ala Ile Leu Ser Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2246
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2246

Leu Ile Gly Ala Ile Leu Arg Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2247
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2247

Leu Ile Gly Ala Ile Leu His Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2248
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2248

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2249
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2249

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Leu Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2250
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2250

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Leu Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2251
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2251

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Cys Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2252
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2252

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Cys Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2253
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2253

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Ala Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2254
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2254

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Leu Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2255
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2255

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Ala Asn Lys Arg Lys Gln 
            20                  25     


<210>  2256
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2256

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Ala Arg Lys Gln 
            20                  25     


<210>  2257
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2257

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Ala Lys Gln 
            20                  25     


<210>  2258
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2258

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Ala Gln 
            20                  25     


<210>  2259
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2259

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Cys 
            20                  25     


<210>  2260
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2260

Leu Leu Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2261
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2261

Leu Ile Gly Ala Leu Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2262
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2262

Tyr Ile Gly Ala Ile Leu Ala Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Ala Asn Lys Arg Lys Gln 
            20                  25     


<210>  2263
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2263

Tyr Ile Gly Ala Ile Leu Ala Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Ala Arg Lys Gln 
            20                  25     


<210>  2264
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2264

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Leu Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2265
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2265

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Cys Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2266
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2266

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Gly Leu 
1               5                   10                  15      

Ile Gly Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2267
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2267

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Cys Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ala Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2268
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2268

Tyr Ile Gly Ala Ile Leu Ala Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Ala Asn Ala Arg Lys Gln 
            20                  25     


<210>  2269
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2269

Tyr Ile Ala Ala Ile Leu Lys Val Leu Ala Ala Ala Leu Ala Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2270
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<400>  2270

Leu Leu Gly Ala Leu Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Leu Ser Trp Leu Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2271
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Melittin-like peptide

<220>
<221>  misc_feature
<222>  2, 5, 17, 20
<223>  Xaa is Nle

<400>  2271

Leu Xaa Gly Ala Xaa Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Xaa Ser Trp Xaa Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2272
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2272

Leu Val Gly Ala Val Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Val Ser Trp Val Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2273
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2273

Gly Leu Gly Ala Leu Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Leu Ser Trp Leu Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2274
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<220>  
<221>  misc_feature
<222>  2, 5, 17, 20
<223>  Xaa is Nle

<400>  2274

Gly Xaa Gly Ala Xaa Leu Lys Val Leu Ala Cys Gly Leu Pro Thr Leu 
1               5                   10                  15      

Xaa Ser Trp Xaa Lys Asn Lys Arg Lys Gln 
            20                  25     


<210>  2275
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2275

Cys Glu Asp Asp Leu Leu Leu Gly Ala Ile Leu Lys Val Leu Ala Thr 
1               5                   10                  15      

Gly Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  2276
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2276

Cys Leu Val Val Leu Ile Val Val Ala Ile Leu Lys Val Leu Ala Thr 
1               5                   10                  15      

Gly Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  2277
<211>  26
<212>  PRT
<213>  Apis mellifera

<400>  2277

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25    


<210>  2278
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2278

Cys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr 
1               5                   10                  15      

Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  2279
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<220>  
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Nle

<400>  2279

Cys Xaa Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr 
1               5                   10                  15      

Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  2280
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2280

Gly Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr 
1               5                   10                  15      

Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  2281
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2281

Leu Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr 
1               5                   10                  15      

Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  2282
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2282

Lys Leu Lys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu 
1               5                   10                  15      

Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  2283
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2283

Lys Leu Lys Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu 
1               5                   10                  15      

Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25    


<210>  2284
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2284

Cys Lys Leu Lys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly 
1               5                   10                  15      

Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  2285
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<220>  
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Nle

<400>  2285

Cys Lys Leu Lys Xaa Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly 
1               5                   10                  15      

Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  2286
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2286

Gly Lys Leu Lys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly 
1               5                   10                  15      

Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  2287
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  D-form Melittin-like peptide

<400>  2287

Cys Pro Ala Asn Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly 
1               5                   10                  15      

Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  2288
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2288

Asp Glu Pro Leu Arg Ala Ile Gly Ala Ile Leu Lys Val Leu Ala Thr 
1               5                   10                  15      

Gly Leu Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25                  30


<210>  2289
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2289

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Cys 
            20                  25        


<210>  2290
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2290

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Cys 
            20                  25        


<210>  2291
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<220>  
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Nle

<400>  2291

Xaa Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Cys 
            20                  25        


<210>  2292
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2292

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Lys Leu Lys Cys 
            20                  25                  30


<210>  2293
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2293

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Pro Leu Gly Ile Ala Gly 
            20                  25                  30

Gln Cys 


<210>  2294
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2294

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Lys Lys Lys Lys Lys 
            20                  25                  30


<210>  2295
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2295

Tyr Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Gly Phe Lys Gly Cys 
            20                  25                  30


<210>  2296
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2296

Cys Phe Lys Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu 
1               5                   10                  15      

Pro Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Cys 
            20                  25                  30


<210>  2297
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2297

Phe Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu Ile 
1               5                   10                  15      

Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25


<210>  2298
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2298

Leu Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys 
            20


<210>  2299
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2299

Leu Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys 
            20


<210>  2300
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2300

Leu Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Gly Glu 
            20


<210>  2301
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2301

Gln Lys Arg Lys Asn Lys Ile Trp Ser Ile Leu Thr Pro Leu Gly Thr 
1               5                   10                  15      

Ala Leu Val Lys Leu Ile Ala Gly Ile Leu 
            20                  25


<210>  2302
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2302

Lys Leu Lys Gln Lys Arg Lys Asn Lys Ile Trp Ser Ile Leu Thr Pro 
1               5                   10                  15      

Leu Gly Thr Ala Leu Val Lys Leu Ile Ala Gly Ile Leu 
            20                  25


<210>  2303
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2303

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Ser Arg Lys Lys Arg Gln Gln 
            20                  25


<210>  2304
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2304

Gly Ile Gly Ala Arg Leu Lys Val Leu Thr Thr Gly Leu Pro Arg Ile 
1               5                   10                  15      

Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25


<210>  2305
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2305

Gly Ile Gly Ala Ile Leu Lys Val Leu Ser Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Gln Glu 
            20                  25


<210>  2306
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2306

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Gly Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25


<210>  2307
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2307

Gly Ile Gly Ala Val Leu Lys Val Leu Ala Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25


<210>  2308
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2308

Gly Ile Gly Ala Val Leu Lys Val Leu Ser Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25


<210>  2309
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2309

Gly Ile Gly Ala Ile Leu Arg Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25


<210>  2310
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2310

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Lys Gln 
            20                  25


<210>  2311
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2311

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Lys Lys Lys Gln Gln 
            20                  25


<210>  2312
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2312

Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln Gly Ser Lys Lys Lys Lys 
            20                  25                  30


<210>  2313
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2313

Lys Lys Gly Ile Gly Ala Ile Leu Lys Val Leu Ala Thr Gly Leu Pro 
1               5                   10                  15      

Thr Leu Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25


<210>  2314
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2314

Gly Ile Gly Ala Ile Leu Glu Val Leu Ala Thr Gly Leu Pro Thr Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Asn Lys Arg Lys Gln 
            20                  25


<210>  2315
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2315

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg 
            20


<210>  2316
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2316

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg 
            20


<210>  2317
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2317

Cys Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      

Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25


<210>  2318
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2318

Gln Gln Arg Lys Arg Lys Ile Trp Ser Ile Leu Ala Pro Leu Gly Thr 
1               5                   10                  15      

Thr Leu Val Lys Leu Val Ala Gly Ile Gly 
            20                  25


<210>  2319
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2319

Gln Gln Arg Lys Arg Lys Ile Trp Ser Ile Leu Ala Pro Leu Gly Thr 
1               5                   10                  15      

Thr Leu Val Lys Leu Val Ala Gly Ile Cys 
            20                  25


<210>  2320
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2320

Gln Gln Lys Lys Lys Lys Ile Trp Ser Ile Leu Ala Pro Leu Gly Thr 
1               5                   10                  15      

Thr Leu Val Lys Leu Val Ala Gly Ile Cys 
            20                  25


<210>  2321
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2321

Gln Lys Arg Lys Asn Lys Ile Trp Ser Ile Leu Thr Pro Leu Gly Thr 
1               5                   10                  15      

Ala Leu Val Lys Leu Ile Ala Gly Ile Gly 
            20                  25


<210>  2322
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>  
<223>  Melittin-like peptide

<400>  2322

Gln Gln Arg Lys Arg Lys Ile Trp Ser Ile Leu Ala Ala Leu Gly Thr 
1               5                   10                  15      

Thr Leu Val Lys Leu Val Ala Gly Ile Cys
            20                  25
