                         SEQUENCE LISTING

<110>  CASE WESTERN RESERVE UNIVERSITY
 
<120>  INSULIN ANALOGUES CONTAINING A GLUCOSE-REGULATED CONFORMATIONAL 
       SWITCH

<130>  20051200321

<140>  PCT/US16/022390
<141>  2016-03-14

<150>  US 62/133,251
<151>  2015-03-13

<150>  US 62/133,704
<151>  2015-03-13

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  5
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr Glu Glu 
            20                  25                  30          


<210>  6
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is an amino acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Ornithine

<400>  6

Phe Val Glu Gln His Leu Cys Gly Ser Xaa Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Xaa Thr 
            20                  25                  30  


<210>  7
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic acid moiety or 
       halogenic derivative of a phenylboronic acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta fluoro Phe, 2 chloro Phe, 2 bromo 
       Phe, 4 chloro Phe, 2 methyl Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Thr or Ser linked to one or more saccharide subunits 
       selected from alpha-D mannopyranoside, alpha-D glucopyranoside, N
       acetyl b D galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Ornithine, Arginine, di amino butyric acid, di 
       amino propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  7

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Xaa Pro Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  8
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic acid moiety or 
       halogenic derivative of a phenylboronic acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta fluoro Phe, 2 chloro Phe, 2 bromo 
       Phe, 4 chloro Phe, 2 methyl Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Thr or Ser linked to one or more saccharide subunits 
       selected from alpha-D mannopyranoside, alpha-D  glucopyranoside, 
       N acetyl b D galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lysine, Arginine, Ornithine, di aminobutyric acid, di 
       aminopropionic acid, Alanine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  8

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Xaa Xaa Pro Thr Xaa Xaa 
            20                  25                  30          


<210>  9
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic acid moiety or 
       halogenic derivative of a phenylboronic acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta fluoro Phe, 2 chloro Phe, 2 bromo 
       Phe, 4 chloro Phe, 2 methyl Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Asn or Gln linked to one or more saccharide subunits 
       selected from alpha-D mannopyranoside, alpha-D glucopyranoside, N
       acetyl b D galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Ornithine, Arginine, di amino butyric acid, di 
       amino propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  9

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Xaa Pro Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  10
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic acid moiety or 
       halogenic derivative of a phenylboronic acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta fluoro Phe, 2 chloro Phe, 2 bromo 
       Phe, 4 chloro Phe, 2 methyl Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Asn or Gln linked to one or more saccharide subunits 
       selected from alpha-D mannopyranoside, alpha-D glucopyranoside, N
       acetyl b D galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lysine, Arginine, Ornithine, di aminobutyric acid, di 
       aminopropionic acid, Alanine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  10

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Xaa Xaa Pro Thr Xaa Xaa 
            20                  25                  30          


<210>  11
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is an Arginine, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  11

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Xaa Pro Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  12
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Arginine, Alanine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  12

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Xaa Xaa Pro Thr Xaa Xaa 
            20                  25                  30          


<210>  13
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is an Arginine, di-amino-butyric acid, di-amino-propionic 
       acid, Norleucine, aminobutyric acid, aminopropionic acid, 
       Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  13

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Xaa Pro Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  14
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Arginine, Ornithine, di-aminobutyric acid, 
       di-aminopropionic acid, Alanine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  14

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Xaa Xaa Pro Thr Xaa Xaa 
            20                  25                  30          


<210>  15
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Ornithine, Arginine, di-amino-butyric acid, 
       di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Thr or Ser linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl-b-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  15

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  16
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lysine, Arginine, Ornithine, di-aminobutyric acid, 
       di-aminopropionic acid, Alanine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Thr or Ser linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl-b-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  16

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Pro Xaa Xaa Xaa 
            20                  25                  30          


<210>  17
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Ornithine, Arginine, di-amino-butyric acid, 
       di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Asn or Gln linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl-b-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  17

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  18
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lysine, Arginine, Ornithine, di-aminobutyric acid, 
       di-aminopropionic acid, Alanine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is Asn or Gln linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl-b-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  18

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Pro Xaa Xaa Xaa 
            20                  25                  30          


<210>  19
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Alanine, Arginine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  19

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  20
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Alanine, Arginine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  20

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Pro Xaa Xaa Xaa 
            20                  25                  30          


<210>  21
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Alanine, Arginine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  21

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Xaa Xaa Xaa 
            20                  25                  30          


<210>  22
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Alanine, Arginine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  22

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Pro Xaa Xaa Xaa 
            20                  25                  30          


<210>  23
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Ornithine, Arginine, di-amino-butyric acid, 
       di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Thr or Ser linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl-Beta-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is Glu, Gln, Gly, Ala, or Ser

<400>  23

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  24
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lysine, Arginine, Ornithine, di-aminobutyric acid, 
       di-aminopropionic acid, Alanine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Asn or Gln linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl- Beta-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is Glu, Gln, Gly, Ala, or Ser

<400>  24

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Pro Thr Xaa Xaa 
            20                  25                  30          


<210>  25
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Ornithine, Arginine, di-amino-butyric acid, 
       di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Asn or Gln linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl- Beta-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is Glu, Gln, Gly, Ala, or Ser

<400>  25

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  26
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lysine, Ornithine, Arginine, di-aminobutyric acid, 
       di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Asn or Gln linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl- Beta-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is Glu, Gln, Gly, Ala, or Ser

<400>  26

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Pro Thr Xaa Xaa 
            20                  25                  30          


<210>  27
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Ornithine, Arginine, di-amino-butyric acid, 
       di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Alanine, Arginine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent or 
       is Glu, Gln, Gly, Ala, or Ser

<400>  27

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  28
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Alanine, Arginine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Alanine, Arginine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent or 
       Glu, Gln, Gly, Ala, or Ser

<400>  28

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Pro Thr Xaa Xaa 
            20                  25                  30          


<210>  29
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Arginine, Norleucine, aminobutyric acid, aminopropionic 
       acid, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Alanine, Arginine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<400>  29

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  30
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Alanine, Arginine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Alanine, Arginine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<400>  30

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Pro Thr Xaa Xaa 
            20                  25                  30          


<210>  31
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Ornithine, Arginine, di-amino-butyric acid, 
       di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Alanine, Arginine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<400>  31

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  32
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Alanine, Arginine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is Alanine, Arginine, Aspartic Acid, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<400>  32

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Pro Thr Xaa Xaa 
            20                  25                  30          


<210>  33
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Proline, Alanine, Arginine, Aspartic Acid, or Glutamic 
       Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  33

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  34
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Proline, Alanine, Arginine, Aspartic Acid, or Glutamic 
       Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<400>  34

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa 
            20                  25                  


<210>  35
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Proline, Lysine, Ornithine, Arginine, di-amino-butyric 
       acid, di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  35

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  36
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Proline, Lysine, Ornithine, Arginine, di-amino-butyric 
       acid, di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<400>  36

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa 
            20                  25                  


<210>  37
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Proline, Arginine, Alanine, Arginine, Aspartic 
       Acid, Glutamic Acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Ornithine, di-aminobutyric acid, or 
       di-aminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  37

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  38
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Proline, Arginine, Alanine, Arginine, Aspartic 
       Acid, Glutamic Acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Ornithine, di-aminobutyric acid, or 
       di-aminopropionic acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<400>  38

Xaa Phe Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu 
1               5                   10                  15      


Tyr Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa 
            20                  25                  30  


<210>  39
<211>  28
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<400>  39

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa 
            20                  25              


<210>  40
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  40

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  41
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Lysine, Proline, Arginine, Alanine, Arginine, Aspartic 
       Acid, Glutamic Acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Ornithine, di-aminobutyric acid, or 
       di-aminopropionic acid

<400>  41

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa 
            20                  25                  


<210>  42
<211>  28
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<400>  42

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa 
            20                  25              


<210>  43
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Proline, Alanine, Arginine, Aspartic Acid, or Glutamic 
       Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  43

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  44
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Proline, Alanine, Arginine, Aspartic Acid, or Glutamic 
       Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is a derivative of the D or L stereoisomer of Lysine, 
       Ornithine, di-aminobutyric acid or di-aminopropionic acid whose 
       side chain amino group is linked to a diol-containing reagent

<400>  44

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa 
            20                  25                  


<210>  45
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lysine, Ornithine, Arginine, di-amino-butyric acid, 
       di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is a derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  45

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  46
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Lysine, Ornithine, Arginine, di-amino-butyric acid, 
       di-amino-propionic acid, Norleucine, aminobutyric acid, 
       aminopropionic acid, Alanine, Aspartic Acid or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa isa derivative of the D or L stereoisomer of Cysteine or 
       Homocysteine whose side-chain sulfur atom is linked to a 
       diol-containing reagent

<400>  46

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa 
            20                  25                  


<210>  47
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Thr or Ser linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl-b-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Arginine, Ornithine, di-aminobutyric acid, 
       di-aminopropionic acid, Proline, Alanine, Aspartic Acid, 
       Glutamine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  47

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  48
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Asn or Gln linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl-b-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Arginine, Ornithine, di-aminobutyric acid, 
       di-aminopropionic acid, Proline, Alanine, Aspartic Acid, 
       Glutamine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  48

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  49
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Arginine, Ornithine, di-aminobutyric acid, 
       di-aminopropionic acid, Proline, Alanine, Aspartic Acid, 
       Glutamine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Thr or Ser linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl-b-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  49

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  50
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Phe modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phenylalanine, penta-fluoro-Phe, 2-chloro-Phe, 
       2-bromo-Phe, 4-chloro-Phe, 2-methyl-Phe, or Cyclohexanylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Arginine, Ornithine, di-aminobutyric acid, 
       di-aminopropionic acid, Proline, Alanine, Aspartic Acid, 
       Glutamine, or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is Asn or Gln linked to one or more saccharide subunits 
       selected from alpha-D-mannopyranoside, alpha-D-glucopyranoside, 
       N-acetyl-b-D-galactopyranoside

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa Xaa is 0-2 amino acids selected from Glu, Gln, Gly, Ala, or 
       Ser and if present, at least one amino acid is Glutamic Acid

<400>  50

Xaa Val Glu Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Xaa Thr Xaa Xaa 
            20                  25                  30          


<210>  51
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Gly or Gly modified with a phenylboronic-acid moiety or 
       halogenic derivative of a phenylboronic-acid moiety connected by 
       peptide linkage or optional acyl linker to the a-amino group of 
       Gly

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Threonine, Alanine, Histidine, Glutamine, Arginine, or 
       Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Trp

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Tyrosine, Alanine or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Glutamic Acid, Glutamine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asparagine, Aspartic Acid, Alanine or Glycine

<400>  51

Xaa Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Xaa Xaa Gln Leu 
1               5                   10                  15      


Xaa Asn Tyr Cys Xaa 
            20      


<210>  52
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is a phenylboronic-acid moiety or halogenic derivative of a 
       phenylboronic-acid moiety connected by to the side-chain amino 
       group of Lysine, Ornithine, di-aminobutyric acid or 
       di-aminopropionic acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Threonine, Alanine, Histidine, Glutamine, Arginine, or 
       Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Trp

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Tyrosine, Alanine or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Glutamic Acid, Glutamine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asparagine, Aspartic Acid, Alanine or Glycine

<400>  52

Gly Ile Val Xaa Gln Cys Cys Xaa Ser Ile Cys Ser Xaa Xaa Gln Leu 
1               5                   10                  15      


Xaa Asn Tyr Cys Xaa 
            20      


<210>  53
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is a basic residue selected from the group consisting of D- 
       or L-Lys, D- or L-Orn, D- or L-di-aminopropionic acid derivatized
       by a phenylboronic acid moiety optionally including a halogenic 
       modification and optionally attached via an acyl linker

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Threonine, Alanine, Histidine, Glutamine, Arginine, or 
       Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Trp

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Tyrosine, Alanine or Glutamic Acid

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Glutamic Acid, Glutamine or Arginine

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asparagine, Aspartic Acid, Alanine or Glycine

<400>  53

Xaa Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Xaa Xaa Gln Leu 
1               5                   10                  15      


Xaa Asn Tyr Cys Xaa 
            20      


