                         SEQUENCE LISTING

<110>  Zimmer, Danna
       McIntush, Eric W.
       Carwile, Henry F.
       Carwile, John M.
 
<120>  ANTIBODIES TARGETING S100B AND METHODS OF USE

<130>  2016-0245A

<150>  US 62/132,975
<151>  2015-03-13

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1398
<212>  DNA
<213>  Mus musculus

<400>  1
atgggatgga gctatatcat cctctttttg gtagcaacag ctacagatgt ccactcccag       60

gtccaactgc agcagcctgg ggctgaactg gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaaggctt ctggctacac cttcaccagg tattggatgc actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tgcagagatt aatcctacca acggtcgtag taactacaat      240

gagaagttca agagcaaggc cacactgact gtagacaggt cctccagcac agccttcatg      300

caactcagca gcctgacatc tgacgactct gcggtctatt actgtgctcc aacagggacg      360

gggtttgctt actggggcca agggactctg gtcactgtct ctgcagccaa aacaacagcc      420

ccatcggtct atccactggc ccctgtgtgt ggagatacaa ctggctcctc ggtgactcta      480

ggatgcctgg tcaagggtta tttccctgag ccagtgacct tgacctggaa ctctggatcc      540

ctgtccagtg gtgtgcacac cttcccagct gtcctgcagt ctgacctcta caccctcagc      600

agctcagtga ctgtaacctc gagcacctgg cccagccagt ccatcacctg caatgtggcc      660

cacccggcaa gcagcaccaa ggtggacaag aaaattgagc ccagagggcc cacaatcaag      720

ccctgtcctc catgcaaatg cccagcacct aacctcttgg gtggaccatc cgtcttcatc      780

ttccctccaa agatcaagga tgtactcatg atctccctga gccccatagt cacatgtgtg      840

gtggtggatg tgagcgagga tgacccagat gtccagatca gctggtttgt gaacaacgtg      900

gaagtacaca cagctcagac acaaacccat agagaggatt acaacagtac tctccgggtg      960

gtcagtgccc tccccatcca gcaccaggac tggatgagtg gcaaggagtt caaatgcaag     1020

gtcaacaaca aagacctccc agcgcccatc gagagaacca tctcaaaacc caaagggtca     1080

gtaagagctc cacaggtata tgtcttgcct ccaccagaag aagagatgac taagaaacag     1140

gtcactctga cctgcatggt cacagacttc atgcctgaag acatttacgt ggagtggacc     1200

aacaacggga aaacagagct aaactacaag aacactgaac cagtcctgga ctctgatggt     1260

tcttacttca tgtacagcaa gctgagagtg gaaaagaaga actgggtgga aagaaatagc     1320

tactcctgtt cagtggtcca cgagggtctg cacaatcacc acacgactaa gagcttctcc     1380

cggactccgg gtaaatga                                                   1398


<210>  2
<211>  465
<212>  PRT
<213>  Mus musculus

<400>  2

Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Asp 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Arg Tyr Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ala Glu Ile Asn Pro Thr Asn Gly Arg Ser Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Phe Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Pro Thr Gly Thr Gly Phe Ala Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val Tyr 
    130                 135                 140                 


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
145                 150                 155                 160 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
                165                 170                 175     


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
        195                 200                 205             


Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 
    210                 215                 220                 


Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys 
225                 230                 235                 240 


Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
            260                 265                 270         


Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
        275                 280                 285             


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
    290                 295                 300                 


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
305                 310                 315                 320 


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
                325                 330                 335     


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
            340                 345                 350         


Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
        355                 360                 365             


Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
    370                 375                 380                 


Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
385                 390                 395                 400 


Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 
            420                 425                 430         


Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
        435                 440                 445             


Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  3
<211>  720
<212>  DNA
<213>  Mus musculus

<400>  3
atgatgagtc ctgcccagtt cctgtttctg ttagtgctct ggattcagga aaccaacggt       60

gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctct      120

atctcttgca agtcaagtca gagcctctta tatagtaatg gaaaaaccta tttgaattgg      180

ttattacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      240

tctggagtcc ctgacaggtt cactggcagt ggatcaggaa cagattttac actgaaaatc      300

agcagagtgg aggctgagga tttgggagtt tattactgcg tgcaaggtac acattttccg      360

tggacgttcg gtggaggcac caagctggaa atcaaacggg ctgatgctgc accaactgta      420

tccatcttcc caccatccag tgagcagtta acatctggag gtgcctcagt cgtgtgcttc      480

ttgaacaact tctaccccaa agacatcaat gtcaagtgga agattgatgg cagtgaacga      540

caaaatggcg tcctgaacag ttggactgat caggacagca aagacagcac ctacagcatg      600

agcagcaccc tcacgttgac caaggacgag tatgaacgac ataacagcta tacctgtgag      660

gccactcaca agacatcaac ttcacccatt gtcaagagct tcaacaggaa tgagtgttag      720


<210>  4
<211>  239
<212>  PRT
<213>  Mus musculus

<400>  4

Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Gln 
1               5                   10                  15      


Glu Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
            20                  25                  30          


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Val Gln Gly Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  5
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  5

Glu Leu Ser His Phe Leu Glu Glu Ile Lys Glu Gln Glu 
1               5                   10              


<210>  6
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Glu Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His 
1               5                   10                  15      


Gln Tyr Ser Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu 
            20                  25                  30          


Leu Lys Glu Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile 
        35                  40                  45              


Lys Glu Gln Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Asn Asp 
    50                  55                  60                  


Gly Asp Gly Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met 
65                  70                  75                  80  


Val Thr Thr Ala Cys His Glu Phe Phe Glu His Glu 
                85                  90          


<210>  7
<211>  92
<212>  PRT
<213>  Mus musculus

<400>  7

Met Ser Glu Leu Glu Lys Ala Met Val Ala Leu Ile Asp Val Phe His 
1               5                   10                  15      


Gln Tyr Ser Gly Arg Glu Gly Asp Lys His Lys Leu Lys Lys Ser Glu 
            20                  25                  30          


Leu Lys Glu Leu Ile Asn Asn Glu Leu Ser His Phe Leu Glu Glu Ile 
        35                  40                  45              


Lys Glu Gln Glu Val Val Asp Lys Val Met Glu Thr Leu Asp Glu Asp 
    50                  55                  60                  


Gly Asp Gly Glu Cys Asp Phe Gln Glu Phe Met Ala Phe Val Ala Met 
65                  70                  75                  80  


Val Thr Thr Ala Cys His Glu Phe Phe Glu His Glu 
                85                  90          


<210>  8
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  8
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc aggtattgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattgcagag attaatccta ccaacggtcg tagtaactac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca ggtcctccag cacagccttc      240

atgcaactca gcagcctgac atctgacgac tctgcggtct attactgtgc tccaacaggg      300

acggggtttg cttactgggg ccaagggact ctggtcactg tctctgca                   348


<210>  9
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Glu Ile Asn Pro Thr Asn Gly Arg Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Thr Gly Thr Gly Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ala 
        115     


<210>  10
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  10
gatgttgtga tgacccagac tccactcact ttgtcggtta ccattggaca accagcctct       60

atctcttgca agtcaagtca gagcctctta tatagtaatg gaaaaaccta tttgaattgg      120

ttattacaga ggccaggcca gtctccaaag cgcctaatct atctggtgtc taaactggac      180

tctggagtcc ctgacaggtt cactggcagt ggatcaggaa cagattttac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tattactgcg tgcaaggtac acattttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaa                                336


<210>  11
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  11

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly 
                85                  90                  95      


Thr His Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


