                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       YARDEN, Yosef
       CARVALHO, Silvia
       LINDZEN, Moshit
 
<120>  ANTI AMPHIREGULIN ANTIBODIES, COMPOSITIONS COMPRISING SAME AND 
       USES THEREOF

<130>  65359

<150>  IL 237852
<151>  2015-03-19

<160>  92    

<170>  PatentIn version 3.5

<210>  1
<211>  360
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain (IgG) complete nucleotide coding sequence

<400>  1
gaggttcagc tgcagcagtc tggggcagag cttgtgaggt caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gactcctata tgcactgggt gaaacagagg      120

cctgaacagg gcctggagtg gattggatgg gttgatcctg ataatggtga tactgaatat      180

gccccggagt tccagggcag ggccactctg actgcagaca cattctccag cacagcctac      240

ctgcagctca ccagcctgac atctgaggac actgccgtct attactgtaa tgccccatct      300

acctatggtc actacggttt tgcttactgg ggccaaggaa ctctggtcac tgtctctgca      360


<210>  2
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain (IgG) complete amino acids coding sequence

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Val Asp Pro Asp Asn Gly Asp Thr Glu Tyr Ala Pro Glu Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Leu Thr Ala Asp Thr Phe Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Pro Ser Thr Tyr Gly His Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  3
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain CDR1 nucleotide coding sequence

<400>  3
ggcttcaaca ttaaagactc ctat                                              24


<210>  4
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain CDR1 amino acids coding sequence

<400>  4

Gly Phe Asn Ile Lys Asp Ser Tyr 
1               5               


<210>  5
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain CDR2 nucleotide coding sequence

<400>  5
gttgatcctg ataatggtga tact                                              24


<210>  6
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain CDR2 amino acids coding sequence

<400>  6

Val Asp Pro Asp Asn Gly Asp Thr 
1               5               


<210>  7
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain CDR3 nucleotide coding sequence

<400>  7
aatgccccat ctacctatgg tcactacggt tttgcttac                              39


<210>  8
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain CDR3 amino acids coding sequence

<400>  8

Asn Ala Pro Ser Thr Tyr Gly His Tyr Gly Phe Ala Tyr 
1               5                   10              


<210>  9
<211>  75
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain FRM1 nucleotide coding sequence

<400>  9
gaggttcagc tgcagcagtc tggggcagag cttgtgaggt caggggcctc agtcaagttg       60

tcctgcacag cttct                                                        75


<210>  10
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain FRM1 amino acids coding sequence

<400>  10

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  11
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain FRM2 nucleotide coding sequence

<400>  11
atgcactggg tgaaacagag gcctgaacag ggcctggagt ggattggatg g                51


<210>  12
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain FRM2 amino acids coding sequence

<400>  12

Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Trp 
    


<210>  13
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain FRM3 nucleotide coding sequence

<400>  13

Gly Ala Ala Thr Ala Thr Gly Cys Cys Cys Cys Gly Gly Ala Gly Thr 
1               5                   10                  15      


Thr Cys Cys Ala Gly Gly Gly Cys Ala Gly Gly Gly Cys Cys Ala Cys 
            20                  25                  30          


Thr Cys Thr Gly Ala Cys Thr Gly Cys Ala Gly Ala Cys Ala Cys Ala 
        35                  40                  45              


Thr Thr Cys Thr Cys Cys Ala Gly Cys Ala Cys Ala Gly Cys Cys Thr 
    50                  55                  60                  


Ala Cys Cys Thr Gly Cys Ala Gly Cys Thr Cys Ala Cys Cys Ala Gly 
65                  70                  75                  80  


Cys Cys Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala Gly Gly Ala Cys 
                85                  90                  95      


Ala Cys Thr Gly Cys Cys Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr 
            100                 105                 110         


Gly Thr 
        


<210>  14
<211>  26
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 heavy chain FRM3 amino acids coding sequence

<400>  14
yagrattadt sstaytstsd tavyyc                                            26


<210>  15
<211>  339
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 light chain (kappa) complete nucleotide coding sequence

<400>  15
gatattgtga tgacccaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaaagctta cttgtattgg      120

ttcctgcaga ggccgggcca gtctcctcag ctcctaatat atcggatgtc caaccttgcc      180

tcaggagtcc cagacaggtt cagtggcagt gggtcgggaa ctgcttttac actgagaatc      240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatccg      300

ctcacgttcg gtgctggcac aaagctcgag ctaaaacgt                             339


<210>  16
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 light chain (kappa) complete amino acids coding sequence

<400>  16

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Lys Ala Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  17
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 light chain CDR1 nucleotide coding sequence

<400>  17
aagagtctcc tgcatagtaa tggcaaagct tac                                    33


<210>  18
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 light chain CDR1 amino acids coding sequence

<400>  18

Lys Ser Leu Leu His Ser Asn Gly Lys Ala Tyr 
1               5                   10      


<210>  19
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 light chain CDR2 nucleotide coding sequence

<400>  19
cggatgtcc                                                                9


<210>  20
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 light chain CDR2 amino acids coding sequence

<400>  20

Arg Met Ser 
1           


<210>  21
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 light chain CDR3 nucleotide coding sequence

<400>  21
atgcaacatc tagaatatcc gctcacg                                           27


<210>  22
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 light chain CDR3 amino acids coding sequence

<400>  22

Met Gln His Leu Glu Tyr Pro Leu Thr 
1               5                   


<210>  23
<211>  78
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 light chain FRM1 nucleotide coding sequence

<400>  23
gatattgtga tgacccaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc       60

atctcctgca ggtctagt                                                     78


<210>  24
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 light chain FRM1 amino acids coding sequence

<400>  24

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  25
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 light chain FRM2 nucleotide coding sequence

<400>  25
ttgtattggt tcctgcagag gccgggccag tctcctcagc tcctaatata t                51


<210>  26
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 light chain FRM2 amino acids coding sequence

<400>  26

Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  27
<211>  108
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR30 light chain FRM3 nucleotide coding sequence

<400>  27
aaccttgcct caggagtccc agacaggttc agtggcagtg ggtcgggaac tgcttttaca       60

ctgagaatca gtagagtgga ggctgaggat gtgggtgttt attactgt                   108


<210>  28
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR30 light chain FRM3 amino acids coding sequence

<400>  28

Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  29
<211>  369
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain (IgG) complete nucleotide coding sequence


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  n is a, c, g, or t

<400>  29
caggtccngc tgcagcagtc tggggcagaa cttgtgaagc cnggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gacacctata tgcactgggt gaaacagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatcgtag tactaaatat      180

gacccgaagt tccagggcaa ggccactata acagcagaca catcctccaa cacagccgac      240

ctgcacctca gcagcctgac atctgaggac actgccgtct attactgtgc tagactttat      300

ggtgactccg tctggtactt cgatgtctgg ggcgcaggga ccacggtcac cgtctcctca      360

gccaaaacg                                                              369


<210>  30
<211>  123
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain IgG complete amino acids coding sequence

<400>  30

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Arg Ser Thr Lys Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Asp 
65                  70                  75                  80  


Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Gly Asp Ser Val Trp Tyr Phe Asp Val Trp Gly Ala 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Lys Thr 
        115                 120             


<210>  31
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain CDR1 nucleotide coding sequence

<400>  31
ggcttcaaca ttaaagacac ctat                                              24


<210>  32
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain CDR1 amino acids coding sequence

<400>  32

Gly Phe Asn Ile Lys Asp Thr Tyr 
1               5               


<210>  33
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain CDR2 nucleotide coding sequence

<400>  33
attgatcctg cgaatcgtag tact                                              24


<210>  34
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain CDR2 amino acids coding sequence

<400>  34

Ile Asp Pro Ala Asn Arg Ser Thr 
1               5               


<210>  35
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain CDR3 nucleotide coding sequence

<400>  35
gctagacttt atggtgactc cgtctggtac ttcgatgtc                              39


<210>  36
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain CDR3 amino acids coding sequence

<400>  36

Ala Arg Leu Tyr Gly Asp Ser Val Trp Tyr Phe Asp Val 
1               5                   10              


<210>  37
<211>  75
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain FRM1 nucleotide coding sequence

<400>  37
gaggtccagc tgcagcagtc tggggcagaa cttgtgaagc caggggcctc agtcaagttg       60

tcctgcacag cttct                                                        75


<210>  38
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain FRM1 amino acids coding sequence

<400>  38

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  39
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain FRM2 nucleotide coding sequence

<400>  39
atgcactggg tgaaacagag gcctgaacag ggcctggagt ggattggaag g                51


<210>  40
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain FRM2 amino acids coding sequence

<400>  40

Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Arg 
    


<210>  41
<211>  114
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain FRM3 nucleotide coding sequence

<400>  41
aaatatgacc cgaagttcca gggcaaggcc actataacag cagacacatc ctccaacaca       60

gccgacctgc acctcagcag cctgacatct gaggacactg ccgtctatta ctgt            114


<210>  42
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain FRM3 amino acids coding sequence

<400>  42

Lys Tyr Asp Pro Lys Phe Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asn Thr Ala Asp Leu His Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  43
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain FRM4 nucleotide coding sequence

<400>  43
tggggcgcag ggaccacggt caccgtctcc tcagccaaaa cg                          42


<210>  44
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 heavy chain FRM4 amino acids coding sequence

<400>  44

Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
1               5                   10                  


<210>  45
<211>  327
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 light chain (kappa) complete nucleotide coding sequence

<400>  45
caaattgttc tctcccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacttgca gggccggctc aagtgtaaat tacatacact ggtaccagca gaagccagga      120

tcctccccca aaccctggat ttatgccaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagagt ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtggttacc cccccatgct cacgttcggt      300

gctggcacaa agctcgagct aaaacgt                                          327


<210>  46
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 light chain (kappa) complete amino acids coding sequence

<400>  46

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Gly Ser Ser Val Asn Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro Pro Met 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105                 


<210>  47
<211>  15
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 light chain CDR1 nucleotide coding sequence

<400>  47
tcaagtgtaa attac                                                        15


<210>  48
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 light chain CDR1 amino acids coding sequence

<400>  48

Ser Ser Val Asn Tyr 
1               5   


<210>  49
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 light chain CDR2 nucleotide coding sequence

<400>  49
gccacatcc                                                                9


<210>  50
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 light chain CDR2 amino acids coding sequence

<400>  50

Ala Thr Ser 
1           


<210>  51
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 light chain CDR3 nucleotide coding sequence

<400>  51
cagcagtgga gtggttaccc ccccatgctc acg                                    33


<210>  52
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 light chain CDR3 amino acids coding sequence

<400>  52

Gln Gln Trp Ser Gly Tyr Pro Pro Met Leu Thr 
1               5                   10      


<210>  53
<211>  78
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 light chain FRM1 nucleotide coding sequence

<400>  53
caaattgttc tctcccagtc tccagcaatc ctgtctgcat ctccagggga gaaggtcaca       60

atgacttgca gggccggc                                                     78


<210>  54
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 light chain FRM1 amino acids coding sequence

<400>  54

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Gly 
            20                  25      


<210>  55
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 light chain FRM2 nucleotide coding sequence

<400>  55
atacactggt accagcagaa gccaggatcc tcccccaaac cctggattta t                51


<210>  56
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 light chain FRM2 amino acids coding sequence

<400>  56

Ile His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  57
<211>  108
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 light chain FRM3 nucleotide coding sequence

<400>  57
aacctggctt ctggagtccc tgctcgcttc agtggcagtg ggtctgggac ctcttactct       60

ctcacaatca gcagagtgga ggctgaagat gctgccactt attactgc                   108


<210>  58
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 light chain FRM3 amino acids coding sequence

<400>  58

Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  59
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR558 light chain FRM4 nucleotide coding sequence

<400>  59
ttcggtgctg gcacaaagct cgagctaaaa cgt                                    33


<210>  60
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR558 light chain FRM4 amino acids coding sequence

<400>  60

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
1               5                   10      


<210>  61
<211>  351
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain (IgG) complete nucleotide coding sequence

<400>  61
gaggtgaagc tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt aactctggca tgtcttggtt tcgcctgact      120

ccagacaaga ggctggagtg ggtcgcaacc attagtagtg gtagtactta caccttctat      180

ccagacactg tgaaggggcg attcatcatc tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatat attactgtgt aagagaaata      300

tggcccgtct ggggcgcagg gaccacgatc accgtctcct cagccaaaac g               351


<210>  62
<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain IgG complete amino acids coding sequence


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa can be any naturally occurring amino acid

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met Xaa Trp Phe Arg Leu Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Ser Thr Tyr Thr Phe Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Xaa Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Arg Glu Ile Trp Pro Val Trp Gly Ala Gly Thr Thr Ile Thr Val 
            100                 105                 110         


Ser Ser Ala Lys Thr 
        115         


<210>  63
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain CDR1 nucleotide coding sequence

<400>  63
ggattcactt tcagtaactc tggc                                              24


<210>  64
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain CDR1 amino acids coding sequence

<400>  64

Gly Phe Thr Phe Ser Asn Ser Gly 
1               5               


<210>  65
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain CDR2 nucleotide coding sequence

<400>  65
attagtagtg gtagtactta cacc                                              24


<210>  66
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain CDR2 amino acids coding sequence

<400>  66

Ile Ser Ser Gly Ser Thr Tyr Thr 
1               5               


<210>  67
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain CDR3 nucleotide coding sequence

<400>  67
gtaagagaaa tatggcccgt c                                                 21


<210>  68
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain CDR3 amino acids coding sequence

<400>  68

Val Arg Glu Ile Trp Pro Val 
1               5           


<210>  69
<211>  75
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain FRM1 nucleotide coding sequence

<400>  69
gaggtgcagc tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctct                                                        75


<210>  70
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain FRM1 amino acids coding sequence

<400>  70

Glu Val Gln Leu Gln Gln Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  71
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain FRM2 nucleotide coding sequence

<400>  71
atgtcttggt ttcgcctgac tccagacaag aggctggagt gggtcgcaac c                51


<210>  72
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain FRM2 amino acids coding sequence

<400>  72

Met Ser Trp Phe Arg Leu Thr Pro Asp Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  73
<211>  114
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain FRM3 nucleotide coding sequence

<400>  73
ttctatccag acactgtgaa ggggcgattc atcatctcca gagacaatgc caagaacacc       60

ctgtacctgc aaatgagcag tctgaagtct gaggacacag ccatatatta ctgt            114


<210>  74
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain FRM3 amino acids coding sequence

<400>  74

Phe Tyr Pro Asp Thr Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  75
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain FRM4 nucleotide coding sequence

<400>  75
tggggcgcag ggaccacgat caccgtctcc tcagccaaaa cg                          42


<210>  76
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AR37 heavy chain FRM4 amino acids coding sequence

<400>  76

Trp Gly Ala Gly Thr Thr Ile Thr Val Ser Ser Ala Lys Thr 
1               5                   10                  


<210>  77
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  77
acttcataga ctccatcaag aa                                                22


<210>  78
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  78
ctcgtccagc ttgactcgat                                                   20


<210>  79
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  79
tccatcttct acaggcagtc ct                                                22


<210>  80
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  80
agccacacgt ggattgtctt                                                   20


<210>  81
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  81
cactggagcc aaaacctgtc                                                   20


<210>  82
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  82
agtgactgag cggctaatgc                                                   20


<210>  83
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  83
gctgtggtgc tgtcatctgt                                                   20


<210>  84
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  84
tcatgcccaa cttcactttc t                                                 21


<210>  85
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  85
gtttttggtg caggaggaca                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  86
caccaacgta cccagaatgg                                                   20


<210>  87
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  87
gccactgctt tgcagaaaat                                                   20


<210>  88
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  88
cctcttcatg tggtcccaag                                                   20


<210>  89
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  89
tgcctgccgt gtgaaccatg t                                                 21


<210>  90
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  90
tgcggcatct tcaaacctcc atga                                              24


<210>  91
<211>  294
<212>  DNA
<213>  Artificial sequence

<220>
<223>  AREGs EGF-like domain (human)

<400>  91
tcagtcagag ttgaacaggt agttaagccc ccccaaaaca agacggaaag tgaaaatact       60

tcagataaac ccaaaagaaa gaaaaaggga ggcaaaaatg gaaaaaatag aagaaacaga      120

aagaagaaaa atccatgtaa tgcagaattt caaaatttct gcattcacgg agaatgcaaa      180

tatatagagc acctggaagc agtaacatgc aaatgtcagc aagaatattt cggtgaacgg      240

tgtggggaaa agtccatgaa aactcacagc atgattgaca gtagtttatc aaaa            294


<210>  92
<211>  98
<212>  PRT
<213>  Artificial sequence

<220>
<223>  AREGs EGF-like domain (human)

<400>  92

Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln Asn Lys Thr Glu 
1               5                   10                  15      


Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys Lys Gly Gly Lys 
            20                  25                  30          


Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn Pro Cys Asn Ala 
        35                  40                  45              


Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys Tyr Ile Glu His 
    50                  55                  60                  


Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr Phe Gly Glu Arg 
65                  70                  75                  80  


Cys Gly Glu Lys Ser Met Lys Thr His Ser Met Ile Asp Ser Ser Leu 
                85                  90                  95      


Ser Lys 
        


