                         SEQUENCE LISTING

<110>  Institut de Cardiologie de Montreal
 
<120>  PCSK9 INHIBITORY POLYPEPTIDES AND METHODS OF USE

<130>  20111-185

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  692
<212>  PRT
<213>  Homo Sapien

<400>  1

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Val Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Gly Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln 
    690         


<210>  2
<211>  860
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  3
<211>  803
<212>  PRT
<213>  Homo Sapien

<400>  3

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Lys 
785                 790                 795                 800 


Asp Glu Leu 
            


<210>  4
<211>  27
<212>  PRT
<213>  Synthetic

<400>  4

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  5
<211>  48
<212>  PRT
<213>  Synthetic

<400>  5

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met 
            20                  25                  30          


Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
        35                  40                  45              


<210>  6
<211>  148
<212>  PRT
<213>  Synthetic

<400>  6

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys 
            20                  25                  30          


Thr Phe Glu Ile Asn Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg 
        35                  40                  45              


Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val 
    50                  55                  60                  


Val Leu Phe Glu Thr Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp 
65                  70                  75                  80  


Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu 
                85                  90                  95      


Asn Ile Asp Pro Asp Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro 
            100                 105                 110         


Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp 
        115                 120                 125             


Glu Glu Met Asp Val Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu 
    130                 135                 140                 


Ser Thr Ala Glu 
145             


<210>  7
<211>  169
<212>  PRT
<213>  Synthetic

<400>  7

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met 
            20                  25                  30          


Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
        35                  40                  45              


Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn Pro Arg His Pro Leu Ile 
    50                  55                  60                  


Arg Asp Met Leu Arg Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr Val 
65                  70                  75                  80  


Leu Asp Leu Ala Val Val Leu Phe Glu Thr Ala Thr Leu Arg Ser Gly 
                85                  90                  95      


Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg Met 
            100                 105                 110         


Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp Ala Lys Val Glu Glu Glu 
        115                 120                 125             


Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp Thr 
    130                 135                 140                 


Glu Gln Asp Glu Asp Glu Glu Met Asp Val Gly Thr Asp Glu Glu Glu 
145                 150                 155                 160 


Glu Thr Ala Lys Glu Ser Thr Ala Glu 
                165                 


<210>  8
<211>  27
<212>  PRT
<213>  Synthetic

<400>  8

Tyr Gly Trp Thr Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  9
<211>  27
<212>  PRT
<213>  Synthetic

<400>  9

Tyr Gly Trp Ser Gly Asn Ser Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  10
<211>  27
<212>  PRT
<213>  Synthetic

<400>  10

Tyr Gly Trp Ser Gly Asn Ser Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  11
<211>  27
<212>  PRT
<213>  Synthetic

<400>  11

Tyr Gly Trp Ser Gly Asn Met Asn Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  12
<211>  27
<212>  PRT
<213>  Synthetic

<400>  12

Tyr Gly Trp Ser Gly Asn Met Glu Lys Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  13
<211>  27
<212>  PRT
<213>  Synthetic

<400>  13

Tyr Gly Trp Ser Gly Asn Met Glu Arg Leu Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  14
<211>  27
<212>  PRT
<213>  Synthetic

<400>  14

Tyr Gly Trp Ser Gly Asn Met Glu Arg Val Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  15
<211>  27
<212>  PRT
<213>  Synthetic

<400>  15

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Ser Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  16
<211>  27
<212>  PRT
<213>  Synthetic

<400>  16

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Arg Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  17
<211>  27
<212>  PRT
<213>  Synthetic

<400>  17

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Leu Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  18
<211>  27
<212>  PRT
<213>  Synthetic

<400>  18

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Val Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  19
<211>  27
<212>  PRT
<213>  Synthetic

<400>  19

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Asn Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  20
<211>  27
<212>  PRT
<213>  Synthetic

<400>  20

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Val Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  21
<211>  27
<212>  PRT
<213>  Synthetic

<400>  21

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Leu Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  22
<211>  27
<212>  PRT
<213>  Synthetic

<400>  22

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ile Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  23
<211>  27
<212>  PRT
<213>  Synthetic

<400>  23

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Asn Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  24
<211>  27
<212>  PRT
<213>  Synthetic

<400>  24

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Ser Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  25
<211>  27
<212>  PRT
<213>  Synthetic

<400>  25

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Arg Asp Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  26
<211>  27
<212>  PRT
<213>  Synthetic

<400>  26

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Glu Ile Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  27
<211>  27
<212>  PRT
<213>  Synthetic

<400>  27

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Leu Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  28
<211>  27
<212>  PRT
<213>  Synthetic

<400>  28

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Val Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  29
<211>  27
<212>  PRT
<213>  Synthetic

<400>  29

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ala Ser Thr Asn Tyr Tyr 
            20                  25          


<210>  30
<211>  27
<212>  PRT
<213>  Synthetic

<400>  30

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Thr Thr Asn Tyr Tyr 
            20                  25          


<210>  31
<211>  27
<212>  PRT
<213>  Synthetic

<400>  31

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Ser Asn Tyr Tyr 
            20                  25          


<210>  32
<211>  27
<212>  PRT
<213>  Synthetic

<400>  32

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Gln Tyr Tyr 
            20                  25          


<210>  33
<211>  81
<212>  DNA
<213>  synthetic

<400>  33
tacggatggt ctggcaacat ggagagaatc atgaaagcac aagcgtacca aacgggcaag       60

gacatctcta caaattacta t                                                 81


<210>  34
<211>  147
<212>  DNA
<213>  Synthetic

<400>  34
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gcttacggat ggtctggcaa catggagaga atcatgaaag cacaagcgta ccaaacgggc      120

aaggacatct ctacaaatta ctattaa                                          147


<210>  35
<211>  444
<212>  DNA
<213>  synthetic

<400>  35
tacggatggt ctggcaacat ggagagaatc atgaaagcac aagcgtacca aacgggcaag       60

gacatctcta caaattacta tgcgagtcag aagaaaacat ttgaaattaa tcccagacac      120

ccgctgatca gagacatgct tcgacgaatt aaggaagatg aagatgataa aacagttttg      180

gatcttgctg tggttttgtt tgaaacagca acgcttcggt cagggtatct tttaccagac      240

actaaagcat atggagatag aatagaaaga atgcttcgcc tcagtttgaa cattgaccct      300

gatgcaaagg tggaagaaga gcctgaagaa gaacctgaag agacagcaga agacacaaca      360

gaagacacag agcaagacga agatgaagaa atggatgtgg gaacagatga agaagaagaa      420

acagcaaagg aatctacagc tgaa                                             444


<210>  36
<211>  510
<212>  DNA
<213>  Synthetic

<400>  36
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gcttacggat ggtctggcaa catggagaga atcatgaaag cacaagcgta ccaaacgggc      120

aaggacatct ctacaaatta ctatgcgagt cagaagaaaa catttgaaat taatcccaga      180

cacccgctga tcagagacat gcttcgacga attaaggaag atgaagatga taaaacagtt      240

ttggatcttg ctgtggtttt gtttgaaaca gcaacgcttc ggtcagggta tcttttacca      300

gacactaaag catatggaga tagaatagaa agaatgcttc gcctcagttt gaacattgac      360

cctgatgcaa aggtggaaga agagcctgaa gaagaacctg aagagacagc agaagacaca      420

acagaagaca cagagcaaga cgaagatgaa gaaatggatg tgggaacaga tgaagaagaa      480

gaaacagcaa aggaatctac agctgaataa                                       510


<210>  37
<211>  108
<212>  PRT
<213>  synthetic

<400>  37

Thr Ala Cys Gly Gly Ala Thr Gly Gly Thr Cys Thr Gly Gly Cys Ala 
1               5                   10                  15      


Ala Cys Ala Thr Gly Gly Ala Gly Ala Gly Ala Ala Thr Cys Ala Thr 
            20                  25                  30          


Gly Ala Ala Ala Gly Cys Ala Cys Ala Ala Gly Cys Gly Thr Ala Cys 
        35                  40                  45              


Cys Ala Ala Ala Cys Gly Gly Gly Cys Ala Ala Gly Gly Ala Cys Ala 
    50                  55                  60                  


Thr Cys Thr Cys Thr Ala Cys Ala Ala Ala Thr Thr Ala Cys Thr Ala 
65                  70                  75                  80  


Thr Thr Ala Cys Cys Cys Ala Thr Ala Thr Gly Ala Cys Gly Thr Cys 
                85                  90                  95      


Cys Cys Gly Gly Ala Thr Thr Ala Cys Gly Cys Thr 
            100                 105             


<210>  38
<211>  99
<212>  PRT
<213>  synthetic

<400>  38

Thr Ala Cys Gly Gly Ala Thr Gly Gly Thr Cys Thr Gly Gly Cys Ala 
1               5                   10                  15      


Ala Cys Ala Thr Gly Gly Ala Gly Ala Gly Ala Ala Thr Cys Ala Thr 
            20                  25                  30          


Gly Ala Ala Ala Gly Cys Ala Cys Ala Ala Gly Cys Gly Thr Ala Cys 
        35                  40                  45              


Cys Ala Ala Ala Cys Gly Gly Gly Cys Ala Ala Gly Gly Ala Cys Ala 
    50                  55                  60                  


Thr Cys Thr Cys Thr Ala Cys Ala Ala Ala Thr Thr Ala Cys Thr Ala 
65                  70                  75                  80  


Thr Cys Ala Cys Cys Ala Cys Cys Ala Cys Cys Ala Cys Cys Ala Cys 
                85                  90                  95      


Cys Ala Cys 
            


<210>  39
<211>  126
<212>  PRT
<213>  synthetic

<400>  39

Thr Ala Cys Gly Gly Ala Thr Gly Gly Thr Cys Thr Gly Gly Cys Ala 
1               5                   10                  15      


Ala Cys Ala Thr Gly Gly Ala Gly Ala Gly Ala Ala Thr Cys Ala Thr 
            20                  25                  30          


Gly Ala Ala Ala Gly Cys Ala Cys Ala Ala Gly Cys Gly Thr Ala Cys 
        35                  40                  45              


Cys Ala Ala Ala Cys Gly Gly Gly Cys Ala Ala Gly Gly Ala Cys Ala 
    50                  55                  60                  


Thr Cys Thr Cys Thr Ala Cys Ala Ala Ala Thr Thr Ala Cys Thr Ala 
65                  70                  75                  80  


Thr Thr Ala Cys Cys Cys Ala Thr Ala Thr Gly Ala Cys Gly Thr Cys 
                85                  90                  95      


Cys Cys Gly Gly Ala Thr Thr Ala Cys Gly Cys Thr Cys Ala Cys Cys 
            100                 105                 110         


Ala Cys Cys Ala Cys Cys Ala Cys Cys Ala Cys Cys Ala Cys 
        115                 120                 125     


<210>  40
<211>  57
<212>  PRT
<213>  Synthetic

<400>  40

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met 
            20                  25                  30          


Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
        35                  40                  45              


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
    50                  55          


<210>  41
<211>  189
<212>  PRT
<213>  synthetic

<400>  41

Ala Thr Gly Ala Gly Gly Gly Cys Cys Cys Thr Gly Thr Gly Gly Gly 
1               5                   10                  15      


Thr Gly Cys Thr Gly Gly Gly Cys Cys Thr Cys Thr Gly Cys Thr Gly 
            20                  25                  30          


Cys Gly Thr Cys Cys Thr Gly Cys Thr Gly Ala Cys Cys Thr Thr Cys 
        35                  40                  45              


Gly Gly Gly Thr Cys Gly Gly Thr Cys Ala Gly Ala Gly Cys Thr Thr 
    50                  55                  60                  


Ala Cys Gly Gly Ala Thr Gly Gly Thr Cys Thr Gly Gly Cys Ala Ala 
65                  70                  75                  80  


Cys Ala Thr Gly Gly Ala Gly Ala Gly Ala Ala Thr Cys Ala Thr Gly 
                85                  90                  95      


Ala Ala Ala Gly Cys Ala Cys Ala Ala Gly Cys Gly Thr Ala Cys Cys 
            100                 105                 110         


Ala Ala Ala Cys Gly Gly Gly Cys Ala Ala Gly Gly Ala Cys Ala Thr 
        115                 120                 125             


Cys Thr Cys Thr Ala Cys Ala Ala Ala Thr Thr Ala Cys Thr Ala Thr 
    130                 135                 140                 


Thr Ala Cys Cys Cys Ala Thr Ala Thr Gly Ala Cys Gly Thr Cys Cys 
145                 150                 155                 160 


Cys Gly Gly Ala Thr Thr Ala Cys Gly Cys Thr Cys Ala Cys Cys Ala 
                165                 170                 175     


Cys Cys Ala Cys Cys Ala Cys Cys Ala Cys Cys Ala Cys 
            180                 185                 


<210>  42
<211>  126
<212>  PRT
<213>  synthetic

<400>  42

Thr Ala Cys Gly Gly Ala Thr Gly Gly Thr Cys Thr Gly Gly Cys Ala 
1               5                   10                  15      


Ala Cys Ala Thr Gly Gly Ala Gly Ala Gly Ala Ala Thr Cys Ala Thr 
            20                  25                  30          


Gly Ala Ala Ala Gly Cys Ala Cys Ala Ala Gly Cys Gly Thr Ala Cys 
        35                  40                  45              


Cys Ala Ala Ala Cys Gly Gly Gly Cys Ala Ala Gly Gly Ala Cys Ala 
    50                  55                  60                  


Thr Cys Thr Cys Thr Ala Cys Ala Ala Ala Thr Thr Ala Cys Thr Ala 
65                  70                  75                  80  


Thr Thr Ala Cys Cys Cys Ala Thr Ala Thr Gly Ala Cys Gly Thr Cys 
                85                  90                  95      


Cys Cys Gly Gly Ala Thr Thr Ala Cys Gly Cys Thr Cys Ala Cys Cys 
            100                 105                 110         


Ala Cys Cys Ala Cys Cys Ala Cys Cys Ala Cys Cys Ala Cys 
        115                 120                 125     


<210>  43
<211>  157
<212>  PRT
<213>  Synthetic

<400>  43

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys 
            20                  25                  30          


Thr Phe Glu Ile Asn Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg 
        35                  40                  45              


Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val 
    50                  55                  60                  


Val Leu Phe Glu Thr Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp 
65                  70                  75                  80  


Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu 
                85                  90                  95      


Asn Ile Asp Pro Asp Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro 
            100                 105                 110         


Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp 
        115                 120                 125             


Glu Glu Met Asp Val Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu 
    130                 135                 140                 


Ser Thr Ala Glu Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
145                 150                 155         


<210>  44
<211>  163
<212>  PRT
<213>  synthetic

<400>  44

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys 
            20                  25                  30          


Thr Phe Glu Ile Asn Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg 
        35                  40                  45              


Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val 
    50                  55                  60                  


Val Leu Phe Glu Thr Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp 
65                  70                  75                  80  


Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu 
                85                  90                  95      


Asn Ile Asp Pro Asp Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro 
            100                 105                 110         


Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp 
        115                 120                 125             


Glu Glu Met Asp Val Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu 
    130                 135                 140                 


Ser Thr Ala Glu Tyr Pro Tyr Asp Val Pro Asp Tyr Ala His His His 
145                 150                 155                 160 


His His His 
            


<210>  45
<211>  154
<212>  PRT
<213>  synthetic

<400>  45

Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr 
1               5                   10                  15      


Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys 
            20                  25                  30          


Thr Phe Glu Ile Asn Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg 
        35                  40                  45              


Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val 
    50                  55                  60                  


Val Leu Phe Glu Thr Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp 
65                  70                  75                  80  


Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu 
                85                  90                  95      


Asn Ile Asp Pro Asp Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro 
            100                 105                 110         


Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp 
        115                 120                 125             


Glu Glu Met Asp Val Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu 
    130                 135                 140                 


Ser Thr Ala Glu His His His His His His 
145                 150                 


<210>  46
<211>  178
<212>  PRT
<213>  Synthetic

<400>  46

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met 
            20                  25                  30          


Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
        35                  40                  45              


Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn Pro Arg His Pro Leu Ile 
    50                  55                  60                  


Arg Asp Met Leu Arg Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr Val 
65                  70                  75                  80  


Leu Asp Leu Ala Val Val Leu Phe Glu Thr Ala Thr Leu Arg Ser Gly 
                85                  90                  95      


Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg Met 
            100                 105                 110         


Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp Ala Lys Val Glu Glu Glu 
        115                 120                 125             


Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp Thr 
    130                 135                 140                 


Glu Gln Asp Glu Asp Glu Glu Met Asp Val Gly Thr Asp Glu Glu Glu 
145                 150                 155                 160 


Glu Thr Ala Lys Glu Ser Thr Ala Glu Tyr Pro Tyr Asp Val Pro Asp 
                165                 170                 175     


Tyr Ala 
        


<210>  47
<211>  184
<212>  PRT
<213>  synthetic

<400>  47

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met 
            20                  25                  30          


Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
        35                  40                  45              


Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn Pro Arg His Pro Leu Ile 
    50                  55                  60                  


Arg Asp Met Leu Arg Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr Val 
65                  70                  75                  80  


Leu Asp Leu Ala Val Val Leu Phe Glu Thr Ala Thr Leu Arg Ser Gly 
                85                  90                  95      


Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg Met 
            100                 105                 110         


Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp Ala Lys Val Glu Glu Glu 
        115                 120                 125             


Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp Thr 
    130                 135                 140                 


Glu Gln Asp Glu Asp Glu Glu Met Asp Val Gly Thr Asp Glu Glu Glu 
145                 150                 155                 160 


Glu Thr Ala Lys Glu Ser Thr Ala Glu Tyr Pro Tyr Asp Val Pro Asp 
                165                 170                 175     


Tyr Ala His His His His His His 
            180                 


<210>  48
<211>  175
<212>  PRT
<213>  synthetic

<400>  48

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Tyr Gly Trp Ser Gly Asn Met Glu Arg Ile Met 
            20                  25                  30          


Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp Ile Ser Thr Asn Tyr Tyr 
        35                  40                  45              


Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn Pro Arg His Pro Leu Ile 
    50                  55                  60                  


Arg Asp Met Leu Arg Arg Ile Lys Glu Asp Glu Asp Asp Lys Thr Val 
65                  70                  75                  80  


Leu Asp Leu Ala Val Val Leu Phe Glu Thr Ala Thr Leu Arg Ser Gly 
                85                  90                  95      


Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly Asp Arg Ile Glu Arg Met 
            100                 105                 110         


Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp Ala Lys Val Glu Glu Glu 
        115                 120                 125             


Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu Asp Thr Thr Glu Asp Thr 
    130                 135                 140                 


Glu Gln Asp Glu Asp Glu Glu Met Asp Val Gly Thr Asp Glu Glu Glu 
145                 150                 155                 160 


Glu Thr Ala Lys Glu Ser Thr Ala Glu His His His His His His 
                165                 170                 175 


<210>  49
<211>  489
<212>  DNA
<213>  synthetic

<400>  49
tacggatggt ctggcaacat ggagagaatc atgaaagcac aagcgtacca aacgggcaag       60

gacatctcta caaattacta tgcgagtcag aagaaaacat ttgaaattaa tcccagacac      120

ccgctgatca gagacatgct tcgacgaatt aaggaagatg aagatgataa aacagttttg      180

gatcttgctg tggttttgtt tgaaacagca acgcttcggt cagggtatct tttaccagac      240

actaaagcat atggagatag aatagaaaga atgcttcgcc tcagtttgaa cattgaccct      300

gatgcaaagg tggaagaaga gcctgaagaa gaacctgaag agacagcaga agacacaaca      360

gaagacacag agcaagacga agatgaagaa atggatgtgg gaacagatga agaagaagaa      420

acagcaaagg aatctacagc tgaataccca tatgacgtcc cggattacgc tcaccaccac      480

caccaccac                                                              489


<210>  50
<211>  116
<212>  DNA
<213>  Synthetic

<400>  50
atggctagct acggatggtc tggcaacatg gagagaatca tgaaagcaca agcgtaccaa       60

acgggcaagg acatctctac aaattactat tcgagcacca ccaccaccac cactaa          116


<210>  51
<211>  126
<212>  DNA
<213>  synthetic

<400>  51
tacggatggt ctggcaacat ggagagaatc atgaaagcac aagcgtacca aacgggcaag       60

gacatctcta caaattacta ttacccatat gacgtcccgg attacgctca ccaccaccac      120

caccac                                                                 126


<210>  52
<211>  189
<212>  DNA
<213>  Synthetic

<400>  52
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gcttacggat ggtctggcaa catggagaga atcatgaaag cacaagcgta ccaaacgggc      120

aaggacatct ctacaaatta ctattaccca tatgacgtcc cggattacgc tcaccaccac      180

caccaccac                                                              189


<210>  53
<211>  189
<212>  DNA
<213>  synthetic

<400>  53
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gcttacggat ggtctggcaa catggagaga atcatgaaag cacaagcgta ccaaacgggc      120

aaggacatct ctacaaatta ctattaccca tatgacgtcc cggattacgc tcaccaccac      180

caccaccac                                                              189


<210>  54
<211>  462
<212>  DNA
<213>  synthetic

<400>  54
tacggatggt ctggcaacat ggagagaatc atgaaagcac aagcgtacca aacgggcaag       60

gacatctcta caaattacta tgcgagtcag aagaaaacat ttgaaattaa tcccagacac      120

ccgctgatca gagacatgct tcgacgaatt aaggaagatg aagatgataa aacagttttg      180

gatcttgctg tggttttgtt tgaaacagca acgcttcggt cagggtatct tttaccagac      240

actaaagcat atggagatag aatagaaaga atgcttcgcc tcagtttgaa cattgaccct      300

gatgcaaagg tggaagaaga gcctgaagaa gaacctgaag agacagcaga agacacaaca      360

gaagacacag agcaagacga agatgaagaa atggatgtgg gaacagatga agaagaagaa      420

acagcaaagg aatctacagc tgaacaccac caccaccacc ac                         462


<210>  55
<211>  471
<212>  DNA
<213>  synthetic

<400>  55
tacggatggt ctggcaacat ggagagaatc atgaaagcac aagcgtacca aacgggcaag       60

gacatctcta caaattacta tgcgagtcag aagaaaacat ttgaaattaa tcccagacac      120

ccgctgatca gagacatgct tcgacgaatt aaggaagatg aagatgataa aacagttttg      180

gatcttgctg tggttttgtt tgaaacagca acgcttcggt cagggtatct tttaccagac      240

actaaagcat atggagatag aatagaaaga atgcttcgcc tcagtttgaa cattgaccct      300

gatgcaaagg tggaagaaga gcctgaagaa gaacctgaag agacagcaga agacacaaca      360

gaagacacag agcaagacga agatgaagaa atggatgtgg gaacagatga agaagaagaa      420

acagcaaagg aatctacagc tgaataccca tatgacgtcc cggattacgc t               471


<210>  56
<211>  507
<212>  DNA
<213>  Synthetic

<400>  56
atggctagct acggatggtc tggcaacatg gagagaatca tgaaagcaca agcgtaccaa       60

acgggcaagg acatctctac aaattactat gcgagtcaga agaaaacatt tgaaattaat      120

cccagacacc cgctgatcag agacatgctt cgacgaatta aggaagatga agatgataaa      180

acagttttgg atcttgctgt ggttttgttt gaaacagcaa cgcttcggtc agggtatctt      240

ttaccagaca ctaaagcata tggagataga atagaaagaa tgcttcgcct cagtttgaac      300

attgaccctg atgcaaaggt ggaagaagag cctgaagaag aacctgaaga gacagcagaa      360

gacacaacag aagacacaga gcaagacgaa gatgaagaaa tggatgtggg aacagatgaa      420

gaagaagaaa cagcaaagga atctacagct gaatacccat atgacgtccc ggattacgct      480

ctcgagcacc accaccacca ccactaa                                          507


<210>  57
<211>  479
<212>  DNA
<213>  Synthetic

<400>  57
atggctagct acggatggtc tggcaacatg gagagaatca tgaaagcaca agcgtaccaa       60

acgggcaagg acatctctac aaattactat gcgagtcaga agaaaacatt tgaaattaat      120

cccagacacc cgctgatcag agacatgctt cgacgaatta aggaagatga agatgataaa      180

acagttttgg atcttgctgt ggttttgttt gaaacagcaa cgcttcggtc agggtatctt      240

ttaccagaca ctaaagcata tggagataga atagaaagaa tgcttcgcct cagtttgaac      300

attgaccctg atgcaaaggt ggaagaagag cctgaagaag aacctgaaga gacagcagaa      360

gacacaacag aagacacaga gcaagacgaa gatgaagaaa tggatgtggg aacagatgaa      420

gaagaagaaa cagcaaagga atctacagct gaatcgagca ccaccaccac caccactaa       479


<210>  58
<211>  537
<212>  DNA
<213>  Synthetic

<400>  58
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gcttacggat ggtctggcaa catggagaga atcatgaaag cacaagcgta ccaaacgggc      120

aaggacatct ctacaaatta ctatgcgagt cagaagaaaa catttgaaat taatcccaga      180

cacccgctga tcagagacat gcttcgacga attaaggaag atgaagatga taaaacagtt      240

ttggatcttg ctgtggtttt gtttgaaaca gcaacgcttc ggtcagggta tcttttacca      300

gacactaaag catatggaga tagaatagaa agaatgcttc gcctcagttt gaacattgac      360

cctgatgcaa aggtggaaga agagcctgaa gaagaacctg aagagacagc agaagacaca      420

acagaagaca cagagcaaga cgaagatgaa gaaatggatg tgggaacaga tgaagaagaa      480

gaaacagcaa aggaatctac agctgaatac ccatatgacg tcccggatta cgcttaa         537


<210>  59
<211>  552
<212>  DNA
<213>  synthetic

<400>  59
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gcttacggat ggtctggcaa catggagaga atcatgaaag cacaagcgta ccaaacgggc      120

aaggacatct ctacaaatta ctatgcgagt cagaagaaaa catttgaaat taatcccaga      180

cacccgctga tcagagacat gcttcgacga attaaggaag atgaagatga taaaacagtt      240

ttggatcttg ctgtggtttt gtttgaaaca gcaacgcttc ggtcagggta tcttttacca      300

gacactaaag catatggaga tagaatagaa agaatgcttc gcctcagttt gaacattgac      360

cctgatgcaa aggtggaaga agagcctgaa gaagaacctg aagagacagc agaagacaca      420

acagaagaca cagagcaaga cgaagatgaa gaaatggatg tgggaacaga tgaagaagaa      480

gaaacagcaa aggaatctac agctgaatac ccatatgacg tcccggatta cgctcaccac      540

caccaccacc ac                                                          552


<210>  60
<211>  525
<212>  DNA
<213>  synthetic

<400>  60
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gcttacggat ggtctggcaa catggagaga atcatgaaag cacaagcgta ccaaacgggc      120

aaggacatct ctacaaatta ctatgcgagt cagaagaaaa catttgaaat taatcccaga      180

cacccgctga tcagagacat gcttcgacga attaaggaag atgaagatga taaaacagtt      240

ttggatcttg ctgtggtttt gtttgaaaca gcaacgcttc ggtcagggta tcttttacca      300

gacactaaag catatggaga tagaatagaa agaatgcttc gcctcagttt gaacattgac      360

cctgatgcaa aggtggaaga agagcctgaa gaagaacctg aagagacagc agaagacaca      420

acagaagaca cagagcaaga cgaagatgaa gaaatggatg tgggaacaga tgaagaagaa      480

gaaacagcaa aggaatctac agctgaacac caccaccacc accac                      525


<210>  61
<211>  134
<212>  PRT
<213>  Homo Sapiens

<400>  61

Met Asp Pro Gln Thr Ala Pro Ser Arg Ala Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Leu His Leu Ala Phe Leu Gly Gly Arg Ser His Pro Leu Gly Ser Pro 
            20                  25                  30          


Gly Ser Ala Ser Asp Leu Glu Thr Ser Gly Leu Gln Glu Gln Arg Asn 
        35                  40                  45              


His Leu Gln Gly Lys Leu Ser Glu Leu Gln Val Glu Gln Thr Ser Leu 
    50                  55                  60                  


Glu Pro Leu Gln Glu Ser Pro Arg Pro Thr Gly Val Trp Lys Ser Arg 
65                  70                  75                  80  


Glu Val Ala Thr Glu Gly Ile Arg Gly His Arg Lys Met Val Leu Tyr 
                85                  90                  95      


Thr Leu Arg Ala Pro Arg Ser Pro Lys Met Val Gln Gly Ser Gly Cys 
            100                 105                 110         


Phe Gly Arg Lys Met Asp Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys 
        115                 120                 125             


Lys Val Leu Arg Arg His 
    130                 


<210>  62
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  62

Met His Leu Ser Gln Leu Leu Ala Cys Ala Leu Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Ala Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly 
        35                  40                  45              


Gly Gln Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  63
<211>  153
<212>  PRT
<213>  Homo Sapiens

<400>  63

Met Ser Ser Phe Ser Thr Thr Thr Val Ser Phe Leu Leu Leu Leu Ala 
1               5                   10                  15      


Phe Gln Leu Leu Gly Gln Thr Arg Ala Asn Pro Met Tyr Asn Ala Val 
            20                  25                  30          


Ser Asn Ala Asp Leu Met Asp Phe Lys Asn Leu Leu Asp His Leu Glu 
        35                  40                  45              


Glu Lys Met Pro Leu Glu Asp Glu Val Val Pro Pro Gln Val Leu Ser 
    50                  55                  60                  


Glu Pro Asn Glu Glu Ala Gly Ala Ala Leu Ser Pro Leu Pro Glu Val 
65                  70                  75                  80  


Pro Pro Trp Thr Gly Glu Val Ser Pro Ala Gln Arg Asp Gly Gly Ala 
                85                  90                  95      


Leu Gly Arg Gly Pro Trp Asp Ser Ser Asp Arg Ser Ala Leu Leu Lys 
            100                 105                 110         


Ser Lys Leu Arg Ala Leu Leu Thr Ala Pro Arg Ser Leu Arg Arg Ser 
        115                 120                 125             


Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly Ala Gln Ser Gly Leu 
    130                 135                 140                 


Gly Cys Asn Ser Phe Arg Tyr Arg Arg 
145                 150             


<210>  64
<211>  808
<212>  PRT
<213>  Homo Sapiens

<400>  64

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Ala Ala Ser Ala 
                645                 650                 655     


Ala Ala Ala Ala Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Tyr 
785                 790                 795                 800 


Pro Tyr Asp Val Pro Asp Tyr Ala 
                805             


<210>  65
<211>  808
<212>  PRT
<213>  Homo Sapiens

<400>  65

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Ala Thr Gly Lys Ala 
            660                 665                 670         


Ile Ser Thr Asn Ala Ala Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Tyr 
785                 790                 795                 800 


Pro Tyr Asp Val Pro Asp Tyr Ala 
                805             


<210>  66
<211>  808
<212>  PRT
<213>  Synthetic

<400>  66

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu Tyr 
785                 790                 795                 800 


Pro Tyr Asp Val Pro Asp Tyr Ala 
                805             


<210>  67
<211>  799
<212>  PRT
<213>  Homo Sapiens

<400>  67

Met Arg Ala Leu Trp Val Leu Gly Leu Cys Cys Val Leu Leu Thr Phe 
1               5                   10                  15      


Gly Ser Val Arg Ala Asp Asp Glu Val Asp Val Asp Gly Thr Val Glu 
            20                  25                  30          


Glu Asp Leu Gly Lys Ser Arg Glu Gly Ser Arg Thr Asp Asp Glu Val 
        35                  40                  45              


Val Gln Arg Glu Glu Glu Ala Ile Gln Leu Asp Gly Leu Asn Ala Ser 
    50                  55                  60                  


Gln Ile Arg Glu Leu Arg Glu Lys Ser Glu Lys Phe Ala Phe Gln Ala 
65                  70                  75                  80  


Glu Val Asn Arg Met Met Lys Leu Ile Ile Asn Ser Leu Tyr Lys Asn 
                85                  90                  95      


Lys Glu Ile Phe Leu Arg Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu 
            100                 105                 110         


Asp Lys Ile Arg Leu Ile Ser Leu Thr Asp Glu Asn Ala Leu Ser Gly 
        115                 120                 125             


Asn Glu Glu Leu Thr Val Lys Ile Lys Cys Asp Lys Glu Lys Asn Leu 
    130                 135                 140                 


Leu His Val Thr Asp Thr Gly Val Gly Met Thr Arg Glu Glu Leu Val 
145                 150                 155                 160 


Lys Asn Leu Gly Thr Ile Ala Lys Ser Gly Thr Ser Glu Phe Leu Asn 
                165                 170                 175     


Lys Met Thr Glu Ala Gln Glu Asp Gly Gln Ser Thr Ser Glu Leu Ile 
            180                 185                 190         


Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Phe Leu Val Ala Asp Lys 
        195                 200                 205             


Val Ile Val Thr Ser Lys His Asn Asn Asp Thr Gln His Ile Trp Glu 
    210                 215                 220                 


Ser Asp Ser Asn Glu Phe Ser Val Ile Ala Asp Pro Arg Gly Asn Thr 
225                 230                 235                 240 


Leu Gly Arg Gly Thr Thr Ile Thr Leu Val Leu Lys Glu Glu Ala Ser 
                245                 250                 255     


Asp Tyr Leu Glu Leu Asp Thr Ile Lys Asn Leu Val Lys Lys Tyr Ser 
            260                 265                 270         


Gln Phe Ile Asn Phe Pro Ile Tyr Val Trp Ser Ser Lys Thr Glu Thr 
        275                 280                 285             


Val Glu Glu Pro Met Glu Glu Glu Glu Ala Ala Lys Glu Glu Lys Glu 
    290                 295                 300                 


Glu Ser Asp Asp Glu Ala Ala Val Glu Glu Glu Glu Glu Glu Lys Lys 
305                 310                 315                 320 


Pro Lys Thr Lys Lys Val Glu Lys Thr Val Trp Asp Trp Glu Leu Met 
                325                 330                 335     


Asn Asp Ile Lys Pro Ile Trp Gln Arg Pro Ser Lys Glu Val Glu Glu 
            340                 345                 350         


Asp Glu Tyr Lys Ala Phe Tyr Lys Ser Phe Ser Lys Glu Ser Asp Asp 
        355                 360                 365             


Pro Met Ala Tyr Ile His Phe Thr Ala Glu Gly Glu Val Thr Phe Lys 
    370                 375                 380                 


Ser Ile Leu Phe Val Pro Thr Ser Ala Pro Arg Gly Leu Phe Asp Glu 
385                 390                 395                 400 


Tyr Gly Ser Lys Lys Ser Asp Tyr Ile Lys Leu Tyr Val Arg Arg Val 
                405                 410                 415     


Phe Ile Thr Asp Asp Phe His Asp Met Met Pro Lys Tyr Leu Asn Phe 
            420                 425                 430         


Val Lys Gly Val Val Asp Ser Asp Asp Leu Pro Leu Asn Val Ser Arg 
        435                 440                 445             


Glu Thr Leu Gln Gln His Lys Leu Leu Lys Val Ile Arg Lys Lys Leu 
    450                 455                 460                 


Val Arg Lys Thr Leu Asp Met Ile Lys Lys Ile Ala Asp Asp Lys Tyr 
465                 470                 475                 480 


Asn Asp Thr Phe Trp Lys Glu Phe Gly Thr Asn Ile Lys Leu Gly Val 
                485                 490                 495     


Ile Glu Asp His Ser Asn Arg Thr Arg Leu Ala Lys Leu Leu Arg Phe 
            500                 505                 510         


Gln Ser Ser His His Pro Thr Asp Ile Thr Ser Leu Asp Gln Tyr Val 
        515                 520                 525             


Glu Arg Met Lys Glu Lys Gln Asp Lys Ile Tyr Phe Met Ala Gly Ser 
    530                 535                 540                 


Ser Arg Lys Glu Ala Glu Ser Ser Pro Phe Val Glu Arg Leu Leu Lys 
545                 550                 555                 560 


Lys Gly Tyr Glu Val Ile Tyr Leu Thr Glu Pro Val Asp Glu Tyr Cys 
                565                 570                 575     


Ile Gln Ala Leu Pro Glu Phe Asp Gly Lys Arg Phe Gln Asn Val Ala 
            580                 585                 590         


Lys Glu Gly Val Lys Phe Asp Glu Ser Glu Lys Thr Lys Glu Ser Arg 
        595                 600                 605             


Glu Ala Val Glu Lys Glu Phe Glu Pro Leu Leu Asn Trp Met Lys Asp 
    610                 615                 620                 


Lys Ala Leu Lys Asp Lys Ile Glu Lys Ala Val Val Ser Gln Arg Leu 
625                 630                 635                 640 


Thr Glu Ser Pro Cys Ala Leu Val Ala Ser Gln Tyr Gly Trp Ser Gly 
                645                 650                 655     


Asn Met Glu Arg Ile Met Lys Ala Gln Ala Tyr Gln Thr Gly Lys Asp 
            660                 665                 670         


Ile Ser Thr Asn Tyr Tyr Ala Ser Gln Lys Lys Thr Phe Glu Ile Asn 
        675                 680                 685             


Pro Arg His Pro Leu Ile Arg Asp Met Leu Arg Arg Ile Lys Glu Asp 
    690                 695                 700                 


Glu Asp Asp Lys Thr Val Leu Asp Leu Ala Val Val Leu Phe Glu Thr 
705                 710                 715                 720 


Ala Thr Leu Arg Ser Gly Tyr Leu Leu Pro Asp Thr Lys Ala Tyr Gly 
                725                 730                 735     


Asp Arg Ile Glu Arg Met Leu Arg Leu Ser Leu Asn Ile Asp Pro Asp 
            740                 745                 750         


Ala Lys Val Glu Glu Glu Pro Glu Glu Glu Pro Glu Glu Thr Ala Glu 
        755                 760                 765             


Asp Thr Thr Glu Asp Thr Glu Gln Asp Glu Asp Glu Glu Met Asp Val 
    770                 775                 780                 


Gly Thr Asp Glu Glu Glu Glu Thr Ala Lys Glu Ser Thr Ala Glu 
785                 790                 795                 


<210>  68
<211>  2799
<212>  DNA
<213>  synthetic

<400>  68
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgagac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaggacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgtg     1380

tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctacagaccg gtcgccacat ggtgagcaag     2100

ggcgaggagg ataacatggc catcatcaag gagttcatgc gcttcaaggt gcacatggag     2160

ggctccgtga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag     2220

ggcacccaga ccgccaagct gaaggtgacc aagggtggcc ccctgccctt cgcctgggac     2280

atcctgtccc ctcagttcat gtacggctcc aaggcctacg tgaagcaccc cgccgacatc     2340

cccgactact tgaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc     2400

gaggacggcg gcgtggtgac cgtgacccag gactcctccc tgcaggacgg cgagttcatc     2460

tacaaggtga agctgcgcgg caccaacttc ccctccgacg gccccgtaat gcagaagaag     2520

accatgggct gggaggcctc ctccgagcgg atgtaccccg aggacggcgc cctgaagggc     2580

gagatcaagc agaggctgaa gctgaaggac ggcggccact acgacgctga ggtcaagacc     2640

acctacaagg ccaagaagcc cgtgcagctg cccggcgcct acaacgtcaa catcaagttg     2700

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgaacg cgccgagggc     2760

cgccactcca ccggcggcat ggacgagctg tacaagtaa                            2799


<210>  69
<211>  7267
<212>  DNA
<213>  sythetic

<400>  69
cccattgacg caaatgggcg gtaggcgtgt acggtgggag gtctatataa gcagagctgg       60

tttagtgaac cgtcagatcc gctagcctcg agaattcatg atcagcttaa tacacaatgg      120

ggccctgggg ctggaaattg cgctggaccg tcgccttgct cctcgccgcg gcggggactg      180

cagtgggcga cagatgtgaa agaaacgagt tccagtgcca agacgggaaa tgcatctcct      240

acaagtgggt ctgcgatggc agcgctgagt gccaggatgg ctctgatgag tcccaggaga      300

cgtgcttgtc tgtcacctgc aaatccgggg acttcagctg tgggggccgt gtcaaccgct      360

gcattcctca gttctggagg tgcgatggcc aagtggactg cgacaacggc tcagacgagc      420

aaggctgtcc ccccaagacg tgctcccagg acgagtttcg ctgccacgat gggaagtgca      480

tctctcggca gttcgtctgt gactcagacc gggactgctt ggacggctca gacgaggcct      540

cctgcccggt gctcacctgt ggtcccgcca gcttccagtg caacagctcc acctgcatcc      600

cccagctgtg ggcctgcgac aacgaccccg actgcgaaga tggctcggat gagtggccgc      660

agcgctgtag gggtctttac gtgttccaag gggacagtag cccctgctcg gccttcgagt      720

tccactgcct aagtggcgag tgcatccact ccagctggcg ctgtgatggt ggccccgact      780

gcaaggacaa atctgacgag gaaaactgcg ctgtggccac ctgtcgccct gacgaattcc      840

agtgctctga tggaaactgc atccatggca gccggcagtg tgaccgggaa tatgactgca      900

aggacatgag cgatgaagtt ggctgcgtta atgtgacact ctgcgaggga cccaacaagt      960

tcaagtgtca cagcggcgaa tgcatcaccc tggacaaagt ctgcaacatg gctagagact     1020

gccgggactg gtcagatgaa cccatcaaag agtgcgggac caacgaatgc ttggacaaca     1080

acggcggctg ttcccacgtc tgcaatgacc ttaagatcgg ctacgagtgc ctgtgccccg     1140

acggcttcca gctggtggcc cagcgaagat gcgaagatat cgatgagtgt caggatcccg     1200

acacctgcag ccagctctgc gtgaacctgg agggtggcta caagtgccag tgtgaggaag     1260

gcttccagct ggacccccac acgaaggcct gcaaggctgt gggctccatc gcctacctct     1320

tcttcaccaa ccggcacgag gtcaggaaga tgacgctgga ccggagcgag tacaccagcc     1380

tcatccccaa cctgaggaac gtggtcgctc tggacacgga ggtggccagc aatagaatct     1440

actggtctga cctgtcccag agaatgatct gcagcaccca gcttgacaga gcccacggcg     1500

tctcttccta tgacaccgtc atcagcaggg acatccaggc ccccgacggg ctggctgtgg     1560

actggatcca cagcaacatc tactggaccg actctgtcct gggcactgtc tctgttgcgg     1620

ataccaaggg cgtgaagagg aaaacgttat tcagggagaa cggctccaag ccaagggcca     1680

tcgtggtgga tcctgttcat ggcttcatgt actggactga ctggggaact cccgccaaga     1740

tcaagaaagg gggcctgaat ggtgtggaca tctactcgct ggtgactgaa aacattcagt     1800

ggcccaatgg catcacccta gatctcctca gtggccgcct ctactgggtt gactccaaac     1860

ttcactccat ctcaagcatc gatgtcaatg ggggcaaccg gaagaccatc ttggaggatg     1920

aaaagaggct ggcccacccc ttctccttgg ccgtctttga ggacaaagta ttttggacag     1980

atatcatcaa cgaagccatt ttcagtgcca accgcctcac aggttccgat gtcaacttgt     2040

tggctgaaaa cctactgtcc ccagaggata tggtcctctt ccacaacctc acccagccaa     2100

gaggagtgaa ctggtgtgag aggaccaccc tgagcaatgg cggctgccag tatctgtgcc     2160

tccctgcccc gcagatcaac ccccactcgc ccaagtttac ctgcgcctgc ccggacggca     2220

tgctgctggc cagggacatg aggagctgcc tcacagaggc tgaggctgca gtggccaccc     2280

aggagacatc caccgtcagg ctaaaggtca gctccacagc cgtaaggaca cagcacacaa     2340

ccacccggcc tgttcccgac acctcccggc tgcctggggc cacccctggg ctcaccacgg     2400

tggagatagt gacaatgtct caccaagctc tgggcgacgt tgctggcaga ggaaatgaga     2460

agaagcccag tagcgtgagg gctctgtcca ttgtcctccc catcgtgctc ctcgtcttcc     2520

tttgcctggg ggtcttcctt ctatggaaga actggcggct taagaacatc aacagcatca     2580

actttgacaa ccccgtctat cagaagacca cagaggatga ggtccacatt tgccacaacc     2640

aggacggcta cagctacccc tcgagacaga tggtcagtct ggaggatgac gtggcgaccg     2700

gtatggtgag caagggcgag gagctgttca ccggggtggt gcccatcctg gtcgagctgg     2760

acggcgacgt aaacggccac aagttcagcg tgtccggcga gggcgagggc gatgccacct     2820

acggcaagct gaccctgaag ttcatctgca ccaccggcaa gctgcccgtg ccctggccca     2880

ccctcgtgac caccctgacc tacggcgtgc agtgcttcag ccgctacccc gaccacatga     2940

agcagcacga cttcttcaag tccgccatgc ccgaaggcta cgtccaggag cgcaccatct     3000

tcttcaagga cgacggcaac tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc     3060

tggtgaaccg catcgagctg aagggcatcg acttcaagga ggacggcaac atcctggggc     3120

acaagctgga gtacaactac aacagccaca acgtctatat catggccgac aagcagaaga     3180

acggcatcaa ggtgaacttc aagatccgcc acaacatcga ggacggcagc gtgcagctcg     3240

ccgaccacta ccagcagaac acccccatcg gcgacggccc cgtgctgctg cccgacaacc     3300

actacctgag cacccagtcc gccctgagca aagaccccaa cgagaagcgc gatcacatgg     3360

tcctgctgga gttcgtgacc gccgccggga tcactctcgg catggacgag ctgtacaagt     3420

aaagcggccg cgactctaga tcataatcag ccataccaca tttgtagagg ttttacttgc     3480

tttaaaaaac ctcccacacc tccccctgaa cctgaaacat aaaatgaatg caattgttgt     3540

tgttaacttg tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt     3600

cacaaataaa gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt     3660

atcttaaggc gtaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt     3720

aaatcagctc attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag     3780

aatagaccga gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga     3840

acgtggactc caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg     3900

aaccatcacc ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc     3960

ctaaagggag cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg     4020

aagggaagaa agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc     4080

gcgtaaccac cacacccgcc gcgcttaatg cgccgctaca gggcgcgtca ggtggcactt     4140

ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt     4200

atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagtc     4260

ctgaggcgga aagaaccagc tgtggaatgt gtgtcagtta gggtgtggaa agtccccagg     4320

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccaggtgtgg     4380

aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc     4440

aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca gttccgccca     4500

ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg ccgcctcggc     4560

ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct tttgcaaaga     4620

tcgatcaaga gacaggatga ggatcgtttc gcatgattga acaagatgga ttgcacgcag     4680

gttctccggc cgcttgggtg gagaggctat tcggctatga ctgggcacaa cagacaatcg     4740

gctgctctga tgccgccgtg ttccggctgt cagcgcaggg gcgcccggtt ctttttgtca     4800

agaccgacct gtccggtgcc ctgaatgaac tgcaagacga ggcagcgcgg ctatcgtggc     4860

tggccacgac gggcgttcct tgcgcagctg tgctcgacgt tgtcactgaa gcgggaaggg     4920

actggctgct attgggcgaa gtgccggggc aggatctcct gtcatctcac cttgctcctg     4980

ccgagaaagt atccatcatg gctgatgcaa tgcggcggct gcatacgctt gatccggcta     5040

cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg agcacgtact cggatggaag     5100

ccggtcttgt cgatcaggat gatctggacg aagagcatca ggggctcgcg ccagccgaac     5160

tgttcgccag gctcaaggcg agcatgcccg acggcgagga tctcgtcgtg acccatggcg     5220

atgcctgctt gccgaatatc atggtggaaa atggccgctt ttctggattc atcgactgtg     5280

gccggctggg tgtggcggac cgctatcagg acatagcgtt ggctacccgt gatattgctg     5340

aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct ttacggtatc gccgctcccg     5400

attcgcagcg catcgccttc tatcgccttc ttgacgagtt cttctgagcg ggactctggg     5460

gttcgaaatg accgaccaag cgacgcccaa cctgccatca cgagatttcg attccaccgc     5520

cgccttctat gaaaggttgg gcttcggaat cgttttccgg gacgccggct ggatgatcct     5580

ccagcgcggg gatctcatgc tggagttctt cgcccaccct agggggaggc taactgaaac     5640

acggaaggag acaataccgg aaggaacccg cgctatgacg gcaataaaaa gacagaataa     5700

aacgcacggt gttgggtcgt ttgttcataa acgcggggtt cggtcccagg gctggcactc     5760

tgtcgatacc ccaccgagac cccattgggg ccaatacgcc cgcgtttctt ccttttcccc     5820

accccacccc ccaagttcgg gtgaaggccc agggctcgca gccaacgtcg gggcggcagg     5880

ccctgccata gcctcaggtt actcatatat actttagatt gatttaaaac ttcattttta     5940

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     6000

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     6060

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     6120

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     6180

agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa     6240

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     6300

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     6360

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     6420

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     6480

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     6540

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     6600

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     6660

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc     6720

ccctgattct gtggataacc gtattaccgc catgcattag ttattaatag taatcaatta     6780

cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg     6840

gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc     6900

ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa     6960

ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct attgacgtca     7020

atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg gactttccta     7080

cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt     7140

acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg     7200

acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca     7260

actccgc                                                               7267


<210>  70
<211>  2427
<212>  DNA
<213>  Synthetic

<400>  70
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gctgacgatg aagttgatgt ggatggtaca gtagaagagg atctgggtaa aagtagagaa      120

ggatcaagga cggatgatga agtagtacag agagaggaag aagctattca gttggatgga      180

ttaaatgcat cacaaataag agaacttaga gagaagtcgg aaaagtttgc cttccaagcc      240

gaagttaaca gaatgatgaa acttatcatc aattcattgt ataaaaataa agagattttc      300

ctgagagaac tgatttcaaa tgcttctgat gctttagata agataaggct aatatcactg      360

actgatgaaa atgctctttc tggaaatgag gaactaacag tcaaaattaa gtgtgataag      420

gagaagaacc tgctgcatgt cacagacacc ggtgtaggaa tgaccagaga agagttggtt      480

aaaaaccttg gtaccatagc caaatctggg acaagcgagt ttttaaacaa aatgactgaa      540

gcacaggaag atggccagtc aacttctgaa ttgattggcc agtttggtgt cggtttctat      600

tccgccttcc ttgtagcaga taaggttatt gtcacttcaa aacacaacaa cgatacccag      660

cacatctggg agtctgactc caatgaattt tctgtaattg ctgacccaag aggaaacact      720

ctaggacggg gaacgacaat tacccttgtc ttaaaagaag aagcatctga ttaccttgaa      780

ttggatacaa ttaaaaatct cgtcaaaaaa tattcacagt tcataaactt tcctatttat      840

gtatggagca gcaagactga aactgttgag gagcccatgg aggaagaaga agcagccaaa      900

gaagagaaag aagaatctga tgatgaagct gcagtagagg aagaagaaga agaaaagaaa      960

ccaaagacta aaaaagttga aaaaactgtc tgggactggg aacttatgaa tgatatcaaa     1020

ccaatatggc agagaccatc aaaagaagta gaagaagatg aatacaaagc tttctacaaa     1080

tcattttcaa aggaaagtga tgaccccatg gcttatattc actttactgc tgaaggggaa     1140

gttaccttca aatcaatttt atttgtaccc acatctgctc cacgtggtct gtttgacgaa     1200

tatggatcta aaaagagcga ttacattaag ctctatgtgc gccgtgtatt catcacagac     1260

gacttccatg atatgatgcc taaatacctc aattttgtca agggtgtggt ggactcagat     1320

gatctcccct tgaatgtttc ccgcgagact cttcagcaac ataaactgct taaggtgatt     1380

aggaagaagc ttgttcgtaa aacgctggac atgatcaaga agattgctga tgataaatac     1440

aatgatactt tttggaaaga atttggtacc aacatcaagc ttggtgtgat tgaagaccac     1500

tcgaatcgaa cacgtcttgc taaacttctt aggttccagt cttctcatca tccaactgac     1560

attactagcc tagaccagta tgtggaaaga atgaaggaaa aacaagacaa aatctacttc     1620

atggctgggt ccagcagaaa agaggctgaa tcttctccat ttgttgagcg acttctgaaa     1680

aagggctatg aagttattta cctcacagaa cctgtggatg aatactgtat tcaggccctt     1740

cccgaatttg atgggaagag gttccagaat gttgccaagg aaggagtgaa gttcgatgaa     1800

agtgagaaaa ctaaggagag tcgtgaagca gttgagaaag aatttgagcc tctgctgaat     1860

tggatgaaag ataaagccct taaggacaag attgaaaagg ctgtggtgtc tcagcgcctg     1920

acagaatctc cgtgtgcttt ggtggccagc cagtacgcag cgtctgccgc agctgctgca     1980

atcatgaaag cacaagcgta ccaaacgggc aaggacatct ctacaaatta ctatgcgagt     2040

cagaagaaaa catttgaaat taatcccaga cacccgctga tcagagacat gcttcgacga     2100

attaaggaag atgaagatga taaaacagtt ttggatcttg ctgtggtttt gtttgaaaca     2160

gcaacgcttc ggtcagggta tcttttacca gacactaaag catatggaga tagaatagaa     2220

agaatgcttc gcctcagttt gaacattgac cctgatgcaa aggtggaaga agagcctgaa     2280

gaagaacctg aagagacagc agaagacaca acagaagaca cagagcaaga cgaagatgaa     2340

gaaatggatg tgggaacaga tgaagaagaa gaaacagcaa aggaatctac agctgaatac     2400

ccatatgacg tcccggatta cgcttaa                                         2427


<210>  71
<211>  2428
<212>  DNA
<213>  Synthetic

<400>  71
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gctgacgatg aagttgatgt ggatggtaca gtagaagagg atctgggtaa aagtagagaa      120

ggatcaagga cggatgatga agtagtacag agagaggaag aagctattca gttggatgga      180

ttaaatgcat cacaaataag agaacttaga gagaagtcgg aaaagtttgc cttccaagcc      240

gaagttaaca gaatgatgaa acttatcatc aattcattgt ataaaaataa agagattttc      300

ctgagagaac tgatttcaaa tgcttctgat gctttagata agataaggct aatatcactg      360

actgatgaaa atgctctttc tggaaatgag gaactaacag tcaaaattaa gtgtgataag      420

gagaagaacc tgctgcatgt cacagacacc ggtgtaggaa tgaccagaga agagttggtt      480

aaaaaccttg gtaccatagc caaatctggg acaagcgagt ttttaaacaa aatgactgaa      540

gcacaggaag atggccagtc aacttctgaa ttgattggcc agtttggtgt cggtttctat      600

tccgccttcc ttgtagcaga taaggttatt gtcacttcaa aacacaacaa cgatacccag      660

cacatctggg agtctgactc caatgaattt tctgtaattg ctgacccaag aggaaacact      720

ctaggacggg gaacgacaat tacccttgtc ttaaaagaag aagcatctga ttaccttgaa      780

ttggatacaa ttaaaaatct cgtcaaaaaa tattcacagt tcataaactt tcctatttat      840

gtatggagca gcaagactga aactgttgag gagcccatgg aggaagaaga agcagccaaa      900

gaagagaaag aagaatctga tgatgaagct gcagtagagg aagaagaaga agaaaagaaa      960

ccaaagacta aaaaagttga aaaaactgtc tgggactggg aacttatgaa tgatatcaaa     1020

ccaatatggc agagaccatc aaaagaagta gaagaagatg aatacaaagc tttctacaaa     1080

tcattttcaa aggaaagtga tgaccccatg gcttatattc actttactgc tgaaggggaa     1140

gttaccttca aatcaatttt atttgtaccc acatctgctc cacgtggtct gtttgacgaa     1200

tatggatcta aaaagagcga ttacattaag ctctatgtgc gccgtgtatt catcacagac     1260

gacttccatg atatgatgcc taaatacctc aattttgtca agggtgtggt ggactcagat     1320

gatctcccct tgaatgtttc ccgcgagact cttcagcaac ataaactgct taaggtgatt     1380

aggaagaagc ttgttcgtaa aacgctggac atgatcaaga agattgctga tgataaatac     1440

aatgatactt tttggaaaga atttggtacc aacatcaagc ttggtgtgat tgaagaccac     1500

tcgaatcgaa cacgtcttgc taaacttctt aggttccagt cttctcatca tccaactgac     1560

attactagcc tagaccagta tgtggaaaga atgaaggaaa aacaagacaa aatctacttc     1620

atggctgggt ccagcagaaa agaggctgaa tcttctccat ttgttgagcg acttctgaaa     1680

aagggctatg aagttattta cctcacagaa cctgtggatg aatactgtat tcaggccctt     1740

cccgaatttg atgggaagag gttccagaat gttgccaagg aaggagtgaa gttcgatgaa     1800

agtgagaaaa ctaaggagag tcgtgaagca gttgagaaag aatttgagcc tctgctgaat     1860

tggatgaaag ataaagccct taaggacaag attgaaaagg ctgtggtgtc tcagcgcctg     1920

acagaatctc cgtgtgcttt ggtggccagc cagtacggat ggtctggcaa catggagaga     1980

atcatgaaag cacaagctta cgcaacgggc aaggccatct ctacaaatgc cgctgcgagt     2040

cagaagaaaa catttgaaat taattcccag acacccgctg atcagagaca tgcttcgacg     2100

aattaaggaa gatgaagatg ataaaacagt tttggatctt gctgtggttt tgtttgaaac     2160

agcaacgctt cggtcagggt atcttttacc agacactaaa gcatatggag atagaataga     2220

aagaatgctt cgcctcagtt tgaacattga ccctgatgca aaggtggaag aagagcctga     2280

agaagaacct gaagagacag cagaagacac aacagaagac acagagcaag acgaagatga     2340

agaaatggat gtgggaacag atgaagaaga agaaacagca aaggaatcta cagctgaata     2400

cccatatgac gtcccggatt acgcttaa                                        2428


<210>  72
<211>  2400
<212>  DNA
<213>  Homo Sapien

<400>  72
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gctgacgatg aagttgatgt ggatggtaca gtagaagagg atctgggtaa aagtagagaa      120

ggatcaagga cggatgatga agtagtacag agagaggaag aagctattca gttggatgga      180

ttaaatgcat cacaaataag agaacttaga gagaagtcgg aaaagtttgc cttccaagcc      240

gaagttaaca gaatgatgaa acttatcatc aattcattgt ataaaaataa agagattttc      300

ctgagagaac tgatttcaaa tgcttctgat gctttagata agataaggct aatatcactg      360

actgatgaaa atgctctttc tggaaatgag gaactaacag tcaaaattaa gtgtgataag      420

gagaagaacc tgctgcatgt cacagacacc ggtgtaggaa tgaccagaga agagttggtt      480

aaaaaccttg gtaccatagc caaatctggg acaagcgagt ttttaaacaa aatgactgaa      540

gcacaggaag atggccagtc aacttctgaa ttgattggcc agtttggtgt cggtttctat      600

tccgccttcc ttgtagcaga taaggttatt gtcacttcaa aacacaacaa cgatacccag      660

cacatctggg agtctgactc caatgaattt tctgtaattg ctgacccaag aggaaacact      720

ctaggacggg gaacgacaat tacccttgtc ttaaaagaag aagcatctga ttaccttgaa      780

ttggatacaa ttaaaaatct cgtcaaaaaa tattcacagt tcataaactt tcctatttat      840

gtatggagca gcaagactga aactgttgag gagcccatgg aggaagaaga agcagccaaa      900

gaagagaaag aagaatctga tgatgaagct gcagtagagg aagaagaaga agaaaagaaa      960

ccaaagacta aaaaagttga aaaaactgtc tgggactggg aacttatgaa tgatatcaaa     1020

ccaatatggc agagaccatc aaaagaagta gaagaagatg aatacaaagc tttctacaaa     1080

tcattttcaa aggaaagtga tgaccccatg gcttatattc actttactgc tgaaggggaa     1140

gttaccttca aatcaatttt atttgtaccc acatctgctc cacgtggtct gtttgacgaa     1200

tatggatcta aaaagagcga ttacattaag ctctatgtgc gccgtgtatt catcacagac     1260

gacttccatg atatgatgcc taaatacctc aattttgtca agggtgtggt ggactcagat     1320

gatctcccct tgaatgtttc ccgcgagact cttcagcaac ataaactgct taaggtgatt     1380

aggaagaagc ttgttcgtaa aacgctggac atgatcaaga agattgctga tgataaatac     1440

aatgatactt tttggaaaga atttggtacc aacatcaagc ttggtgtgat tgaagaccac     1500

tcgaatcgaa cacgtcttgc taaacttctt aggttccagt cttctcatca tccaactgac     1560

attactagcc tagaccagta tgtggaaaga atgaaggaaa aacaagacaa aatctacttc     1620

atggctgggt ccagcagaaa agaggctgaa tcttctccat ttgttgagcg acttctgaaa     1680

aagggctatg aagttattta cctcacagaa cctgtggatg aatactgtat tcaggccctt     1740

cccgaatttg atgggaagag gttccagaat gttgccaagg aaggagtgaa gttcgatgaa     1800

agtgagaaaa ctaaggagag tcgtgaagca gttgagaaag aatttgagcc tctgctgaat     1860

tggatgaaag ataaagccct taaggacaag attgaaaagg ctgtggtgtc tcagcgcctg     1920

acagaatctc cgtgtgcttt ggtggccagc cagtacggat ggtctggcaa catggagaga     1980

atcatgaaag cacaagcgta ccaaacgggc aaggacatct ctacaaatta ctatgcgagt     2040

cagaagaaaa catttgaaat taatcccaga cacccgctga tcagagacat gcttcgacga     2100

attaaggaag atgaagatga taaaacagtt ttggatcttg ctgtggtttt gtttgaaaca     2160

gcaacgcttc ggtcagggta tcttttacca gacactaaag catatggaga tagaatagaa     2220

agaatgcttc gcctcagttt gaacattgac cctgatgcaa aggtggaaga agagcctgaa     2280

gaagaacctg aagagacagc agaagacaca acagaagaca cagagcaaga cgaagatgaa     2340

gaaatggatg tgggaacaga tgaagaagaa gaaacagcaa aggaatctac agctgaataa     2400


<210>  73
<211>  2427
<212>  DNA
<213>  Synthetic

<400>  73
atgagggccc tgtgggtgct gggcctctgc tgcgtcctgc tgaccttcgg gtcggtcaga       60

gctgacgatg aagttgatgt ggatggtaca gtagaagagg atctgggtaa aagtagagaa      120

ggatcaagga cggatgatga agtagtacag agagaggaag aagctattca gttggatgga      180

ttaaatgcat cacaaataag agaacttaga gagaagtcgg aaaagtttgc cttccaagcc      240

gaagttaaca gaatgatgaa acttatcatc aattcattgt ataaaaataa agagattttc      300

ctgagagaac tgatttcaaa tgcttctgat gctttagata agataaggct aatatcactg      360

actgatgaaa atgctctttc tggaaatgag gaactaacag tcaaaattaa gtgtgataag      420

gagaagaacc tgctgcatgt cacagacacc ggtgtaggaa tgaccagaga agagttggtt      480

aaaaaccttg gtaccatagc caaatctggg acaagcgagt ttttaaacaa aatgactgaa      540

gcacaggaag atggccagtc aacttctgaa ttgattggcc agtttggtgt cggtttctat      600

tccgccttcc ttgtagcaga taaggttatt gtcacttcaa aacacaacaa cgatacccag      660

cacatctggg agtctgactc caatgaattt tctgtaattg ctgacccaag aggaaacact      720

ctaggacggg gaacgacaat tacccttgtc ttaaaagaag aagcatctga ttaccttgaa      780

ttggatacaa ttaaaaatct cgtcaaaaaa tattcacagt tcataaactt tcctatttat      840

gtatggagca gcaagactga aactgttgag gagcccatgg aggaagaaga agcagccaaa      900

gaagagaaag aagaatctga tgatgaagct gcagtagagg aagaagaaga agaaaagaaa      960

ccaaagacta aaaaagttga aaaaactgtc tgggactggg aacttatgaa tgatatcaaa     1020

ccaatatggc agagaccatc aaaagaagta gaagaagatg aatacaaagc tttctacaaa     1080

tcattttcaa aggaaagtga tgaccccatg gcttatattc actttactgc tgaaggggaa     1140

gttaccttca aatcaatttt atttgtaccc acatctgctc cacgtggtct gtttgacgaa     1200

tatggatcta aaaagagcga ttacattaag ctctatgtgc gccgtgtatt catcacagac     1260

gacttccatg atatgatgcc taaatacctc aattttgtca agggtgtggt ggactcagat     1320

gatctcccct tgaatgtttc ccgcgagact cttcagcaac ataaactgct taaggtgatt     1380

aggaagaagc ttgttcgtaa aacgctggac atgatcaaga agattgctga tgataaatac     1440

aatgatactt tttggaaaga atttggtacc aacatcaagc ttggtgtgat tgaagaccac     1500

tcgaatcgaa cacgtcttgc taaacttctt aggttccagt cttctcatca tccaactgac     1560

attactagcc tagaccagta tgtggaaaga atgaaggaaa aacaagacaa aatctacttc     1620

atggctgggt ccagcagaaa agaggctgaa tcttctccat ttgttgagcg acttctgaaa     1680

aagggctatg aagttattta cctcacagaa cctgtggatg aatactgtat tcaggccctt     1740

cccgaatttg atgggaagag gttccagaat gttgccaagg aaggagtgaa gttcgatgaa     1800

agtgagaaaa ctaaggagag tcgtgaagca gttgagaaag aatttgagcc tctgctgaat     1860

tggatgaaag ataaagccct taaggacaag attgaaaagg ctgtggtgtc tcagcgcctg     1920

acagaatctc cgtgtgcttt ggtggccagc cagtacggat ggtctggcaa catggagaga     1980

atcatgaaag cacaagcgta ccaaacgggc aaggacatct ctacaaatta ctatgcgagt     2040

cagaagaaaa catttgaaat taatcccaga cacccgctga tcagagacat gcttcgacga     2100

attaaggaag atgaagatga taaaacagtt ttggatcttg ctgtggtttt gtttgaaaca     2160

gcaacgcttc ggtcagggta tcttttacca gacactaaag catatggaga tagaatagaa     2220

agaatgcttc gcctcagttt gaacattgac cctgatgcaa aggtggaaga agagcctgaa     2280

gaagaacctg aagagacagc agaagacaca acagaagaca cagagcaaga cgaagatgaa     2340

gaaatggatg tgggaacaga tgaagaagaa gaaacagcaa aggaatctac agctgaatac     2400

ccatatgacg tcccggatta cgcttaa                                         2427


<210>  74
<211>  2799
<212>  DNA
<213>  synthetic

<400>  74
atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg       60

ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag      120

ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc      180

acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg      240

gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc      300

caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct      360

ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc      420

gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg      480

attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg      540

gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc      600

atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc      660

agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc      720

gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg      780

gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg      840

gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc      900

tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgagac      960

gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat     1020

gcccaggacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac     1080

ctctttgccc caggggagga catcattggt gcctccagct actgcagcac ctgctttgtg     1140

tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg     1200

tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc     1260

aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg     1320

gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgtg     1380

tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat     1440

gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg     1500

gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc     1560

tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca     1620

ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca     1680

ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg     1740

ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc     1800

tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag     1860

caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg     1920

acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac     1980

gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg     2040

agccggcacc tggcgcaggc ctcccaggag ctacagaccg gtcgccacat ggtgagcaag     2100

ggcgaggagg ataacatggc catcatcaag gagttcatgc gcttcaaggt gcacatggag     2160

ggctccgtga acggccacga gttcgagatc gagggcgagg gcgagggccg cccctacgag     2220

ggcacccaga ccgccaagct gaaggtgacc aagggtggcc ccctgccctt cgcctgggac     2280

atcctgtccc ctcagttcat gtacggctcc aaggcctacg tgaagcaccc cgccgacatc     2340

cccgactact tgaagctgtc cttccccgag ggcttcaagt gggagcgcgt gatgaacttc     2400

gaggacggcg gcgtggtgac cgtgacccag gactcctccc tgcaggacgg cgagttcatc     2460

tacaaggtga agctgcgcgg caccaacttc ccctccgacg gccccgtaat gcagaagaag     2520

accatgggct gggaggcctc ctccgagcgg atgtaccccg aggacggcgc cctgaagggc     2580

gagatcaagc agaggctgaa gctgaaggac ggcggccact acgacgctga ggtcaagacc     2640

acctacaagg ccaagaagcc cgtgcagctg cccggcgcct acaacgtcaa catcaagttg     2700

gacatcacct cccacaacga ggactacacc atcgtggaac agtacgaacg cgccgagggc     2760

cgccactcca ccggcggcat ggacgagctg tacaagtaa                            2799


<210>  75
<211>  932
<212>  PRT
<213>  synthetic

<400>  75

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Asp Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln Thr Gly Arg His Met Val Ser Lys Gly Glu Glu Asp 
    690                 695                 700                 


Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu 
705                 710                 715                 720 


Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly 
                725                 730                 735     


Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly 
            740                 745                 750         


Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr 
        755                 760                 765             


Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu 
    770                 775                 780                 


Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe 
785                 790                 795                 800 


Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp 
                805                 810                 815     


Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser 
            820                 825                 830         


Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser 
        835                 840                 845             


Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln 
    850                 855                 860                 


Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr 
865                 870                 875                 880 


Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val 
                885                 890                 895     


Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val 
            900                 905                 910         


Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp 
        915                 920                 925             


Glu Leu Tyr Lys 
    930         


<210>  76
<211>  932
<212>  PRT
<213>  synthetic

<400>  76

Met Gly Thr Val Ser Ser Arg Arg Ser Trp Trp Pro Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Gly Pro Ala Gly Ala Arg Ala Gln Glu 
            20                  25                  30          


Asp Glu Asp Gly Asp Tyr Glu Glu Leu Val Leu Ala Leu Arg Ser Glu 
        35                  40                  45              


Glu Asp Gly Leu Ala Glu Ala Pro Glu His Gly Thr Thr Ala Thr Phe 
    50                  55                  60                  


His Arg Cys Ala Lys Asp Pro Trp Arg Leu Pro Gly Thr Tyr Val Val 
65                  70                  75                  80  


Val Leu Lys Glu Glu Thr His Leu Ser Gln Ser Glu Arg Thr Ala Arg 
                85                  90                  95      


Arg Leu Gln Ala Gln Ala Ala Arg Arg Gly Tyr Leu Thr Lys Ile Leu 
            100                 105                 110         


His Val Phe His Gly Leu Leu Pro Gly Phe Leu Val Lys Met Ser Gly 
        115                 120                 125             


Asp Leu Leu Glu Leu Ala Leu Lys Leu Pro His Val Asp Tyr Ile Glu 
    130                 135                 140                 


Glu Asp Ser Ser Val Phe Ala Gln Ser Ile Pro Trp Asn Leu Glu Arg 
145                 150                 155                 160 


Ile Thr Pro Pro Arg Tyr Arg Ala Asp Glu Tyr Gln Pro Pro Asp Gly 
                165                 170                 175     


Gly Ser Leu Val Glu Val Tyr Leu Leu Asp Thr Ser Ile Gln Ser Asp 
            180                 185                 190         


His Arg Glu Ile Glu Gly Arg Val Met Val Thr Asp Phe Glu Asn Val 
        195                 200                 205             


Pro Glu Glu Asp Gly Thr Arg Phe His Arg Gln Ala Ser Lys Cys Asp 
    210                 215                 220                 


Ser His Gly Thr His Leu Ala Gly Val Val Ser Gly Arg Asp Ala Gly 
225                 230                 235                 240 


Val Ala Lys Gly Ala Ser Met Arg Ser Leu Arg Val Leu Asn Cys Gln 
                245                 250                 255     


Gly Lys Gly Thr Val Ser Gly Thr Leu Ile Gly Leu Glu Phe Ile Arg 
            260                 265                 270         


Lys Ser Gln Leu Val Gln Pro Val Gly Pro Leu Val Val Leu Leu Pro 
        275                 280                 285             


Leu Ala Gly Gly Tyr Ser Arg Val Leu Asn Ala Ala Cys Gln Arg Leu 
    290                 295                 300                 


Ala Arg Ala Gly Val Val Leu Val Thr Ala Ala Gly Asn Phe Arg Asp 
305                 310                 315                 320 


Asp Ala Cys Leu Tyr Ser Pro Ala Ser Ala Pro Glu Val Ile Thr Val 
                325                 330                 335     


Gly Ala Thr Asn Ala Gln Asp Gln Pro Val Thr Leu Gly Thr Leu Gly 
            340                 345                 350         


Thr Asn Phe Gly Arg Cys Val Asp Leu Phe Ala Pro Gly Glu Asp Ile 
        355                 360                 365             


Ile Gly Ala Ser Ser Tyr Cys Ser Thr Cys Phe Val Ser Gln Ser Gly 
    370                 375                 380                 


Thr Ser Gln Ala Ala Ala His Val Ala Gly Ile Ala Ala Met Met Leu 
385                 390                 395                 400 


Ser Ala Glu Pro Glu Leu Thr Leu Ala Glu Leu Arg Gln Arg Leu Ile 
                405                 410                 415     


His Phe Ser Ala Lys Asp Val Ile Asn Glu Ala Trp Phe Pro Glu Asp 
            420                 425                 430         


Gln Arg Val Leu Thr Pro Asn Leu Val Ala Ala Leu Pro Pro Ser Thr 
        435                 440                 445             


His Gly Ala Gly Trp Gln Leu Phe Cys Arg Thr Val Trp Ser Ala His 
    450                 455                 460                 


Ser Gly Pro Thr Arg Met Ala Thr Ala Ile Ala Arg Cys Ala Pro Asp 
465                 470                 475                 480 


Glu Glu Leu Leu Ser Cys Ser Ser Phe Ser Arg Ser Gly Lys Arg Arg 
                485                 490                 495     


Gly Glu Arg Met Glu Ala Gln Gly Gly Lys Leu Val Cys Arg Ala His 
            500                 505                 510         


Asn Ala Phe Gly Gly Glu Gly Val Tyr Ala Ile Ala Arg Cys Cys Leu 
        515                 520                 525             


Leu Pro Gln Ala Asn Cys Ser Val His Thr Ala Pro Pro Ala Glu Ala 
    530                 535                 540                 


Ser Met Gly Thr Arg Val His Cys His Gln Gln Gly His Val Leu Thr 
545                 550                 555                 560 


Gly Cys Ser Ser His Trp Glu Val Glu Asp Leu Gly Thr His Lys Pro 
                565                 570                 575     


Pro Val Leu Arg Pro Arg Gly Gln Pro Asn Gln Cys Val Gly His Arg 
            580                 585                 590         


Glu Ala Ser Ile His Ala Ser Cys Cys His Ala Pro Gly Leu Glu Cys 
        595                 600                 605             


Lys Val Lys Glu His Gly Ile Pro Ala Pro Gln Glu Gln Val Thr Val 
    610                 615                 620                 


Ala Cys Glu Glu Gly Trp Thr Leu Thr Gly Cys Ser Ala Leu Pro Gly 
625                 630                 635                 640 


Thr Ser His Val Leu Gly Ala Tyr Ala Val Asp Asn Thr Cys Val Val 
                645                 650                 655     


Arg Ser Arg Asp Val Ser Thr Thr Gly Ser Thr Ser Glu Glu Ala Val 
            660                 665                 670         


Thr Ala Val Ala Ile Cys Cys Arg Ser Arg His Leu Ala Gln Ala Ser 
        675                 680                 685             


Gln Glu Leu Gln Thr Gly Arg His Met Val Ser Lys Gly Glu Glu Asp 
    690                 695                 700                 


Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu 
705                 710                 715                 720 


Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly 
                725                 730                 735     


Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly 
            740                 745                 750         


Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr 
        755                 760                 765             


Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu 
    770                 775                 780                 


Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe 
785                 790                 795                 800 


Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp 
                805                 810                 815     


Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser 
            820                 825                 830         


Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser 
        835                 840                 845             


Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln 
    850                 855                 860                 


Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr 
865                 870                 875                 880 


Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val 
                885                 890                 895     


Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val 
            900                 905                 910         


Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp 
        915                 920                 925             


Glu Leu Tyr Lys 
    930         


<210>  77
<211>  1101
<212>  PRT
<213>  synthetic

<400>  77

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala Thr Gly Met Val 
    850                 855                 860                 


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
865                 870                 875                 880 


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
                885                 890                 895     


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
            900                 905                 910         


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
        915                 920                 925             


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
    930                 935                 940                 


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
945                 950                 955                 960 


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
                965                 970                 975     


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
            980                 985                 990         


Phe Lys Glu Asp Gly Asn Ile Leu  Gly His Lys Leu Glu  Tyr Asn Tyr 
        995                 1000                 1005             


Asn Ser  His Asn Val Tyr Ile  Met Ala Asp Lys Gln  Lys Asn Gly 
    1010                 1015                 1020             


Ile Lys  Val Asn Phe Lys Ile  Arg His Asn Ile Glu  Asp Gly Ser 
    1025                 1030                 1035             


Val Gln  Leu Ala Asp His Tyr  Gln Gln Asn Thr Pro  Ile Gly Asp 
    1040                 1045                 1050             


Gly Pro  Val Leu Leu Pro Asp  Asn His Tyr Leu Ser  Thr Gln Ser 
    1055                 1060                 1065             


Ala Leu  Ser Lys Asp Pro Asn  Glu Lys Arg Asp His  Met Val Leu 
    1070                 1075                 1080             


Leu Glu  Phe Val Thr Ala Ala  Gly Ile Thr Leu Gly  Met Asp Glu 
    1085                 1090                 1095             


Leu Tyr  Lys 
    1100     


