                         SEQUENCE LISTING

<110>  Universitt Stuttgart
       BioNTech AG
 
<120>  Single chain TNF ligand family molecules and fusion proteins and 
       derivatives thereof with improved stability

<130>  762-4 PCT

<150>  EP 15 159 703.6
<151>  2015-03-18

<160>  260   

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can be S, T, or V

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  can be F, Y, or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can be A, L, V or I

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  is a polar or non-polar amino acid

<400>  1

Xaa Xaa Phe Gly Xaa Xaa 
1               5       


<210>  2
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can  be P, K, V, I, or A

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  can  be V, A, or F

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can  be V, L, I, Y

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  can  be V, L, I, or Y

<400>  2

Xaa Xaa Ala His Xaa 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  can be D, S, M, or I

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  can be V, W, F or C

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  can be A or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  can be E, Y, Q, or H

<400>  3

Xaa Xaa Xaa Xaa Leu 
1               5   


<210>  4
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  5
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Phe Phe Gly Ala Phe 
1               5       


<210>  7
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  8
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  9
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Arg Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  10
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  11
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  12
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  13
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro 
1               5                   10                  15      


Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu 
            20                  25                  30          


Ala Cys Leu Gly Leu Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala 
        35                  40                  45              


Ser Leu Ser Ala Gln Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu 
    50                  55                  60                  


Asp Gln Asp Pro Ser Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 
65                  70                  75                  80  


Pro Ala Pro Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 
                85                  90                  95      


Lys Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 
            100                 105                 110         


Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly 
        115                 120                 125             


Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu 
    130                 135                 140                 


Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu 
145                 150                 155                 160 


Tyr Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr 
                165                 170                 175     


Leu Lys Leu Asp Leu Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu 
            180                 185                 190         


Glu Glu Phe Ser Ala Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg 
        195                 200                 205             


Leu Cys Gln Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu 
    210                 215                 220                 


Arg Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu 
225                 230                 235                 240 


Thr Tyr Phe Gly Leu Phe Gln Val His 
                245                 


<210>  14
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  15
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  16
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  16

Thr Phe Phe Gly Leu Tyr 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Tyr Phe Gly Ala Phe 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Phe Phe Gly Ala Phe 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  19

Thr Phe Phe Gly Ala Phe 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  20

Val Tyr Phe Gly Ile Ile 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  21

Thr Ser Phe Gly Leu Leu 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  22

Thr Tyr Phe Gly Leu Phe 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  23

Thr Phe Phe Gly Val Gln 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  24

Thr Phe Phe Gly Ala Leu 
1               5       


<210>  25
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  25

Val Ala Ala His Ile 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  26

Lys Val Ala His Leu 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  27

Pro Ala Ala His Leu 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  28

Pro Val Ala His Val 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  29

Ile Ala Ala His Val 
1               5   


<210>  30
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  30

Ile Ala Ala His Tyr 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  31

Asp Val Ala Glu Leu 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Trp Ala Glu Leu 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  33

Asp Phe Ala Glu Leu 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Cys Ala Glu Leu 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  35

Asp Val Leu Glu Leu 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Val Ala Tyr Leu 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  37

Asp Val Leu Tyr Leu 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  38

Asp Val Ala Gln Leu 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  39

Asp Val Leu Gln Leu 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Val Ala His Leu 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  41

Asp Val Leu His Leu 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  42

Asp Trp Leu Glu Leu 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  43

Asp Trp Ala Tyr Leu 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  44

Asp Trp Leu Tyr Leu 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  45

Asp Trp Ala Gln Leu 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  46

Asp Trp Leu Gln Leu 
1               5   


<210>  47
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  47

Asp Trp Ala His Leu 
1               5   


<210>  48
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  48

Asp Trp Leu His Leu 
1               5   


<210>  49
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Phe Leu Glu Leu 
1               5   


<210>  50
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  50

Asp Phe Ala Tyr Leu 
1               5   


<210>  51
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  51

Asp Phe Leu Tyr Leu 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  52

Asp Phe Ala Gln Leu 
1               5   


<210>  53
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  53

Asp Phe Leu Gln Leu 
1               5   


<210>  54
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  54

Asp Phe Ala His Leu 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  55

Asp Phe Leu His Leu 
1               5   


<210>  56
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  56

Asp Cys Leu Glu Leu 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  57

Asp Cys Ala Tyr Leu 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  58

Asp Cys Leu Tyr Leu 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  59

Asp Cys Ala Gln Leu 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  60

Asp Cys Leu Gln Leu 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  61

Asp Cys Ala His Leu 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  62

Asp Cys Leu His Leu 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  63

Ser Val Ala Glu Leu 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  64

Ser Trp Ala Glu Leu 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  65

Ser Phe Ala Glu Leu 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  66

Ser Cys Ala Glu Leu 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  67

Ser Val Leu Glu Leu 
1               5   


<210>  68
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  68

Ser Val Ala Tyr Leu 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  69

Ser Val Leu Tyr Leu 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  70

Ser Val Ala Gln Leu 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  71

Ser Val Leu Gln Leu 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  72

Ser Val Ala His Leu 
1               5   


<210>  73
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  73

Ser Val Leu His Leu 
1               5   


<210>  74
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  74

Ser Trp Leu Glu Leu 
1               5   


<210>  75
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  75

Ser Trp Ala Tyr Leu 
1               5   


<210>  76
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  76

Ser Trp Leu Tyr Leu 
1               5   


<210>  77
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  77

Ser Trp Ala Gln Leu 
1               5   


<210>  78
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  78

Ser Trp Leu Gln Leu 
1               5   


<210>  79
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  79

Ser Trp Ala His Leu 
1               5   


<210>  80
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  80

Ser Trp Leu His Leu 
1               5   


<210>  81
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  81

Ser Phe Leu Glu Leu 
1               5   


<210>  82
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  82

Ser Phe Ala Tyr Leu 
1               5   


<210>  83
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  83

Ser Phe Leu Tyr Leu 
1               5   


<210>  84
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  84

Ser Phe Ala Gln Leu 
1               5   


<210>  85
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  85

Ser Phe Leu Gln Leu 
1               5   


<210>  86
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  86

Ser Phe Ala His Leu 
1               5   


<210>  87
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  87

Ser Phe Leu His Leu 
1               5   


<210>  88
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  88

Ser Cys Leu Glu Leu 
1               5   


<210>  89
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  89

Ser Cys Ala Tyr Leu 
1               5   


<210>  90
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  90

Ser Cys Leu Tyr Leu 
1               5   


<210>  91
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  91

Ser Cys Ala Gln Leu 
1               5   


<210>  92
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  92

Ser Cys Leu Gln Leu 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  93

Ser Cys Ala His Leu 
1               5   


<210>  94
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  94

Ser Cys Leu His Leu 
1               5   


<210>  95
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Val Ala Glu Leu 
1               5   


<210>  96
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Trp Ala Glu Leu 
1               5   


<210>  97
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Phe Ala Glu Leu 
1               5   


<210>  98
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Cys Ala Glu Leu 
1               5   


<210>  99
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Val Leu Glu Leu 
1               5   


<210>  100
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Val Ala Tyr Leu 
1               5   


<210>  101
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Val Leu Tyr Leu 
1               5   


<210>  102
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Val Ala Gln Leu 
1               5   


<210>  103
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Val Leu Gln Leu 
1               5   


<210>  104
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Val Ala His Leu 
1               5   


<210>  105
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Val Leu His Leu 
1               5   


<210>  106
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Trp Leu Glu Leu 
1               5   


<210>  107
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Trp Ala Tyr Leu 
1               5   


<210>  108
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Trp Leu Tyr Leu 
1               5   


<210>  109
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Trp Ala Gln Leu 
1               5   


<210>  110
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Trp Leu Gln Leu 
1               5   


<210>  111
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Trp Ala His Leu 
1               5   


<210>  112
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Trp Leu His Leu 
1               5   


<210>  113
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Phe Leu Glu Leu 
1               5   


<210>  114
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Phe Ala Tyr Leu 
1               5   


<210>  115
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Phe Leu Tyr Leu 
1               5   


<210>  116
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Phe Ala Gln Leu 
1               5   


<210>  117
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Phe Leu Gln Leu 
1               5   


<210>  118
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Phe Ala His Leu 
1               5   


<210>  119
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Phe Leu His Leu 
1               5   


<210>  120
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Cys Leu Glu Leu 
1               5   


<210>  121
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Cys Ala Tyr Leu 
1               5   


<210>  122
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Cys Leu Tyr Leu 
1               5   


<210>  123
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Cys Ala Gln Leu 
1               5   


<210>  124
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Cys Leu Gln Leu 
1               5   


<210>  125
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Cys Ala His Leu 
1               5   


<210>  126
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Cys Leu His Leu 
1               5   


<210>  127
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  127

Ile Val Ala Glu Leu 
1               5   


<210>  128
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  128

Ile Trp Ala Glu Leu 
1               5   


<210>  129
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  129

Ile Phe Ala Glu Leu 
1               5   


<210>  130
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  130

Ile Cys Ala Glu Leu 
1               5   


<210>  131
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  131

Ile Val Leu Glu Leu 
1               5   


<210>  132
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  132

Ile Val Ala Tyr Leu 
1               5   


<210>  133
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  133

Ile Val Leu Tyr Leu 
1               5   


<210>  134
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  134

Ile Val Ala Gln Leu 
1               5   


<210>  135
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  135

Ile Val Leu Gln Leu 
1               5   


<210>  136
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  136

Ile Val Ala His Leu 
1               5   


<210>  137
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  137

Ile Val Leu His Leu 
1               5   


<210>  138
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  138

Ile Trp Leu Glu Leu 
1               5   


<210>  139
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  139

Ile Trp Ala Tyr Leu 
1               5   


<210>  140
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  140

Ile Trp Leu Tyr Leu 
1               5   


<210>  141
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  141

Ile Trp Ala Gln Leu 
1               5   


<210>  142
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  142

Ile Trp Leu Gln Leu 
1               5   


<210>  143
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  143

Ile Trp Ala His Leu 
1               5   


<210>  144
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  144

Ile Trp Leu His Leu 
1               5   


<210>  145
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  145

Ile Phe Leu Glu Leu 
1               5   


<210>  146
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  146

Ile Phe Ala Tyr Leu 
1               5   


<210>  147
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  147

Ile Phe Leu Tyr Leu 
1               5   


<210>  148
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  148

Ile Phe Ala Gln Leu 
1               5   


<210>  149
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  149

Ile Phe Leu Gln Leu 
1               5   


<210>  150
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  150

Ile Phe Ala His Leu 
1               5   


<210>  151
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  151

Ile Phe Leu His Leu 
1               5   


<210>  152
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  152

Ile Cys Leu Glu Leu 
1               5   


<210>  153
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  153

Ile Cys Ala Tyr Leu 
1               5   


<210>  154
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  154

Ile Cys Leu Tyr Leu 
1               5   


<210>  155
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  155

Ile Cys Ala Gln Leu 
1               5   


<210>  156
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  156

Ile Cys Leu Gln Leu 
1               5   


<210>  157
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  157

Ile Cys Ala His Leu 
1               5   


<210>  158
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  158

Ile Cys Leu His Leu 
1               5   


<210>  159
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  159

Leu Val Gly Gly 
1               


<210>  160
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  160

Leu Val Gly Gly Ile 
1               5   


<210>  161
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  161

Leu Val Ser Gly 
1               


<210>  162
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  162

Ala Val Gly Gly 
1               


<210>  163
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  163

Ala Val Ser Gly 
1               


<210>  164
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  164

Ile Val Gly Gly 
1               


<210>  165
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  165

Ile Val Ser Gly 
1               


<210>  166
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  166

Gly Pro Gln Arg 
1               


<210>  167
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  167

Trp Val Arg Pro 
1               


<210>  168
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  168

Leu Val Val Gly Arg 
1               5   


<210>  169
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  169

Leu Val Gly Gly Gly 
1               5   


<210>  170
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  170

Leu Val Gly Gly Pro 
1               5   


<210>  171
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  171

Leu Val Gly Gly Ala 
1               5   


<210>  172
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  172

Leu Val Gly Gly Pro Gln 
1               5       


<210>  173
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  173

Leu Val Gly Gly Pro Gln Arg 
1               5           


<210>  174
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  174

Leu Val Gly Gly Gly Pro Gln Arg 
1               5               


<210>  175
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  175

Leu Val Gly Gly Gly Gly Pro Gln 
1               5               


<210>  176
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  176

Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Pro Gln Arg Val Ala 
1               5                   10                  15      


Ala His Ile 
            


<210>  177
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  177

Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Pro Gln Arg Val Ala Ala 
1               5                   10                  15      


His Ile 
        


<210>  178
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  178

Ser Phe Phe Gly Ala Phe Leu Val Ser Gly Ile Ala Ala His Ile 
1               5                   10                  15  


<210>  179
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  179

Ser Phe Phe Gly Ala Phe Ala Val Gly Gly Ala Ala Ala His Ile 
1               5                   10                  15  


<210>  180
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  180

Ser Phe Phe Gly Ala Phe Ala Val Gly Gly Ile Ala Ala Ala His Ile 
1               5                   10                  15      


<210>  181
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  181

Ser Phe Phe Gly Ala Phe Ile Val Gly Gly Ile Ala Ala His Ile 
1               5                   10                  15  


<210>  182
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  182

Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ile Ala Ala His Ile 
1               5                   10                  15  


<210>  183
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  183

Ser Phe Phe Gly Ala Phe Ile Val Ser Gly Ile Ala Ala His Ile 
1               5                   10                  15  


<210>  184
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  184

Ser Phe Phe Gly Ala Leu Val Gly Gly Val Ala Ala His Ile 
1               5                   10                  


<210>  185
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  185

Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Arg Val Ala Ala His Ile 
1               5                   10                  15      


<210>  186
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  186

Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Ile Ala Ala His Ile 
1               5                   10                  15  


<210>  187
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  187

Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Ala Ala Ala His Ile 
1               5                   10                  15  


<210>  188
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  188

Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile 
1               5                   10                  15  


<210>  189
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  189

Gly Gly Gly Gly Ser 
1               5   


<210>  190
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  190

Gly Gly Gly Gly Ser Gly Gly Gly 
1               5               


<210>  191
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  191

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  192
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  192

Gly Gly Ser Gly Gly Ala Ser Ser Gly Gly 
1               5                   10  


<210>  193
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  193

Gly Gly Ser Gly Gly Gly Ser Ser Gly Gly 
1               5                   10  


<210>  194
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  194

Ala Ala Ala Gly Asn Gly Thr Ser Asn Gly Thr Ser Glu Phe Gly Gly 
1               5                   10                  15      


<210>  195
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Glu Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            20                  25                  30          


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        35                  40                  45              


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn 
    50                  55                  60                  


Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
65                  70                  75                  80  


Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe 
                85                  90                  95      


Thr Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            100                 105                 110         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        115                 120                 125             


Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys Tyr Ala 
        195                 200                 205             


Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Asn Gly Thr 
            260                 265                 270         


Ser Asn Gly Thr Ser Glu Phe Gly Gly Ile Ala Ala His Ile Thr Gly 
        275                 280                 285             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    290                 295                 300                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
305                 310                 315                 320 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                325                 330                 335     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            340                 345                 350         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        355                 360                 365             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    370                 375                 380                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
385                 390                 395                 400 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                405                 410                 415     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            420                 425                 430         


Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ile Ala Ala His Ile Thr 
        435                 440                 445             


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
    450                 455                 460                 


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
465                 470                 475                 480 


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
                485                 490                 495     


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
            500                 505                 510         


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
        515                 520                 525             


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
    530                 535                 540                 


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
545                 550                 555                 560 


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
                565                 570                 575     


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
            580                 585                 590         


Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ile Ala Ala His Ile 
        595                 600                 605             


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
    610                 615                 620                 


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
625                 630                 635                 640 


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
                645                 650                 655     


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
            660                 665                 670         


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
        675                 680                 685             


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
    690                 695                 700                 


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
705                 710                 715                 720 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
                725                 730                 735     


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
            740                 745                 750         


Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser 
        755                 760             


<210>  196
<211>  752
<212>  PRT
<213>  Homo sapiens

<400>  196

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Gly Thr Glu 
1               5                   10                  15      


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            20                  25                  30          


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr Val 
        35                  40                  45              


Met Ala Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser 
    50                  55                  60                  


Ser Ile Ser Ser Ser Gly Gly Trp Thr Leu Tyr Ala Asp Ser Val Lys 
65                  70                  75                  80  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
                85                  90                  95      


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
            100                 105                 110         


Arg Gly Leu Lys Met Ala Thr Ile Phe Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr 
    130                 135                 140                 


Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr Asn Val Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Glu Val 
            180                 185                 190         


Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Thr Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser Ser Ile Phe Val Ile 
225                 230                 235                 240 


Phe Gly Cys Gly Thr Lys Val Thr Val Leu Ala Ala Ala Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 
            260                 265                 270         


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
        275                 280                 285             


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
    290                 295                 300                 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
305                 310                 315                 320 


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
                325                 330                 335     


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
            340                 345                 350         


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
        355                 360                 365             


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
    370                 375                 380                 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
385                 390                 395                 400 


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
                405                 410                 415     


Gly Ala Phe Leu Val Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile 
            420                 425                 430         


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        435                 440                 445             


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    450                 455                 460                 


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
465                 470                 475                 480 


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                485                 490                 495     


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            500                 505                 510         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        515                 520                 525             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    530                 535                 540                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
545                 550                 555                 560 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                565                 570                 575     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Pro Gln Arg 
            580                 585                 590         


Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
        595                 600                 605             


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
    610                 615                 620                 


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
625                 630                 635                 640 


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
                645                 650                 655     


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
            660                 665                 670         


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
        675                 680                 685             


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
    690                 695                 700                 


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
705                 710                 715                 720 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
                725                 730                 735     


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            740                 745                 750         


<210>  197
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Glu Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            20                  25                  30          


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        35                  40                  45              


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn 
    50                  55                  60                  


Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
65                  70                  75                  80  


Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe 
                85                  90                  95      


Thr Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            100                 105                 110         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        115                 120                 125             


Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 
                165                 170                 175     


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly 
            180                 185                 190         


Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                 200                 205             


Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp 
                245                 250                 255     


Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala 
            260                 265                 270         


Ala Glu Phe Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        275                 280                 285             


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    290                 295                 300                 


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
305                 310                 315                 320 


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                325                 330                 335     


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            340                 345                 350         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        355                 360                 365             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    370                 375                 380                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
385                 390                 395                 400 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                405                 410                 415     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            420                 425                 430         


Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        435                 440                 445             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    450                 455                 460                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
465                 470                 475                 480 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                485                 490                 495     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            500                 505                 510         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        515                 520                 525             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    530                 535                 540                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
545                 550                 555                 560 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                565                 570                 575     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            580                 585                 590         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        595                 600                 605             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    610                 615                 620                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
625                 630                 635                 640 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                645                 650                 655     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            660                 665                 670         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        675                 680                 685             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    690                 695                 700                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
705                 710                 715                 720 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                725                 730                 735     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            740                 745                 750         


Phe Gly Ala Phe Ala Val Ser 
        755                 


<210>  198
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Glu Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            20                  25                  30          


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        35                  40                  45              


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn 
    50                  55                  60                  


Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
65                  70                  75                  80  


Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe 
                85                  90                  95      


Thr Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            100                 105                 110         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        115                 120                 125             


Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys Tyr Ala 
        195                 200                 205             


Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Asn Gly Thr 
            260                 265                 270         


Ser Asn Gly Thr Ser Glu Phe Gly Gly Ala Ala Ala His Ile Thr Gly 
        275                 280                 285             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    290                 295                 300                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
305                 310                 315                 320 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                325                 330                 335     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            340                 345                 350         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        355                 360                 365             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    370                 375                 380                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
385                 390                 395                 400 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                405                 410                 415     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            420                 425                 430         


Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr 
        435                 440                 445             


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
    450                 455                 460                 


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
465                 470                 475                 480 


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
                485                 490                 495     


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
            500                 505                 510         


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
        515                 520                 525             


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
    530                 535                 540                 


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
545                 550                 555                 560 


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
                565                 570                 575     


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
            580                 585                 590         


Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile 
        595                 600                 605             


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
    610                 615                 620                 


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
625                 630                 635                 640 


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
                645                 650                 655     


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
            660                 665                 670         


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
        675                 680                 685             


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
    690                 695                 700                 


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
705                 710                 715                 720 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
                725                 730                 735     


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
            740                 745                 750         


Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser 
        755                 760             


<210>  199
<211>  763
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Glu Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            20                  25                  30          


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        35                  40                  45              


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn 
    50                  55                  60                  


Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
65                  70                  75                  80  


Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe 
                85                  90                  95      


Thr Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            100                 105                 110         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        115                 120                 125             


Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys Tyr Ala 
        195                 200                 205             


Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly 
                245                 250                 255     


Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Asn Gly Thr 
            260                 265                 270         


Ser Asn Gly Thr Ser Glu Phe Gly Gly Ile Ala Ala His Ile Thr Gly 
        275                 280                 285             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    290                 295                 300                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
305                 310                 315                 320 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                325                 330                 335     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            340                 345                 350         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        355                 360                 365             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    370                 375                 380                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
385                 390                 395                 400 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                405                 410                 415     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            420                 425                 430         


Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ile Ala Ala His Ile Thr 
        435                 440                 445             


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
    450                 455                 460                 


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
465                 470                 475                 480 


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
                485                 490                 495     


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
            500                 505                 510         


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
        515                 520                 525             


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
    530                 535                 540                 


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
545                 550                 555                 560 


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
                565                 570                 575     


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
            580                 585                 590         


Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ile Ala Ala His Ile 
        595                 600                 605             


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
    610                 615                 620                 


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
625                 630                 635                 640 


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
                645                 650                 655     


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
            660                 665                 670         


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
        675                 680                 685             


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
    690                 695                 700                 


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
705                 710                 715                 720 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
                725                 730                 735     


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
            740                 745                 750         


Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser 
        755                 760             


<210>  200
<211>  766
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Glu Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            20                  25                  30          


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        35                  40                  45              


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn 
    50                  55                  60                  


Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
65                  70                  75                  80  


Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe 
                85                  90                  95      


Thr Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            100                 105                 110         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        115                 120                 125             


Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
                165                 170                 175     


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            180                 185                 190         


Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        195                 200                 205             


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
225                 230                 235                 240 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                245                 250                 255     


Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly 
            260                 265                 270         


Asn Gly Thr Ser Asn Gly Thr Ser Glu Phe Gly Gly Ala Ala Ala His 
        275                 280                 285             


Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser 
    290                 295                 300                 


Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser 
305                 310                 315                 320 


Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu 
                325                 330                 335     


Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr 
            340                 345                 350         


Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln 
        355                 360                 365             


Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu 
    370                 375                 380                 


Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr 
385                 390                 395                 400 


Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn 
                405                 410                 415     


Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp 
            420                 425                 430         


His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ala Ala Ala 
        435                 440                 445             


His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn 
    450                 455                 460                 


Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser 
465                 470                 475                 480 


Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly 
                485                 490                 495     


Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr 
            500                 505                 510         


Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys 
        515                 520                 525             


Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile 
    530                 535                 540                 


Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu 
545                 550                 555                 560 


Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu 
                565                 570                 575     


Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met 
            580                 585                 590         


Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ala Ala 
        595                 600                 605             


Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
    610                 615                 620                 


Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
625                 630                 635                 640 


Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
                645                 650                 655     


Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
            660                 665                 670         


Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
        675                 680                 685             


Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
    690                 695                 700                 


Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
705                 710                 715                 720 


Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
                725                 730                 735     


Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
            740                 745                 750         


Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser 
        755                 760                 765     


<210>  201
<211>  768
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Glu Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            20                  25                  30          


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
        35                  40                  45              


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn 
    50                  55                  60                  


Tyr Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
65                  70                  75                  80  


Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe 
                85                  90                  95      


Thr Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            100                 105                 110         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        115                 120                 125             


Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser 
                165                 170                 175     


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly 
            180                 185                 190         


Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        195                 200                 205             


Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 
225                 230                 235                 240 


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Asn Trp 
                245                 250                 255     


Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala 
            260                 265                 270         


Ala Gly Asn Gly Thr Ser Asn Gly Thr Ser Glu Phe Gly Gly Ala Ala 
        275                 280                 285             


Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro 
    290                 295                 300                 


Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu 
305                 310                 315                 320 


Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn 
                325                 330                 335     


Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln 
            340                 345                 350         


Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp 
        355                 360                 365             


Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro 
    370                 375                 380                 


Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala 
385                 390                 395                 400 


Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys 
                405                 410                 415     


Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp 
            420                 425                 430         


Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ala 
        435                 440                 445             


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
    450                 455                 460                 


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
465                 470                 475                 480 


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
                485                 490                 495     


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
            500                 505                 510         


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
        515                 520                 525             


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
    530                 535                 540                 


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
545                 550                 555                 560 


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
                565                 570                 575     


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
            580                 585                 590         


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly 
        595                 600                 605             


Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
    610                 615                 620                 


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
625                 630                 635                 640 


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
                645                 650                 655     


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
            660                 665                 670         


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
        675                 680                 685             


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
    690                 695                 700                 


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
705                 710                 715                 720 


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
                725                 730                 735     


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
            740                 745                 750         


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser 
        755                 760                 765             


<210>  202
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  202

Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly 
1               5                   10                  15      


Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly 
            20                  25                  30          


Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val 
        35                  40                  45              


Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu 
    50                  55                  60                  


Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser 
65                  70                  75                  80  


Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu 
                85                  90                  95      


Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn 
            100                 105     


<210>  203
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFvhu225-EHD2 fusion protein

<400>  203

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg Ala Ala Ala Gly Gly Ser Gly Gly Asp Phe Thr Pro Pro Thr 
                245                 250                 255     


Val Lys Ile Leu Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro 
            260                 265                 270         


Thr Ile Gln Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile 
        275                 280                 285             


Asn Ile Thr Trp Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser 
    290                 295                 300                 


Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu 
305                 310                 315                 320 


Leu Thr Leu Ser Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys 
                325                 330                 335     


Gln Val Thr Tyr Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys 
            340                 345                 350         


Ala Asp Ser Asn 
        355     


<210>  204
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv4D5-EHD2

<400>  204

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys Arg Ala Ala Ala Gly Gly Ser Gly Gly Asp Phe Thr Pro Pro 
                245                 250                 255     


Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro 
            260                 265                 270         


Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr 
        275                 280                 285             


Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu 
    290                 295                 300                 


Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser 
305                 310                 315                 320 


Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr 
                325                 330                 335     


Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys 
            340                 345                 350         


Cys Ala Asp Ser Asn 
        355         


<210>  205
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein hu225 IgG heavy chain-scTRAIL3-FAVSGAA

<400>  205

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala 
            20                  25                  30          


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        35                  40                  45              


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr 
    50                  55                  60                  


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
65                  70                  75                  80  


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
                85                  90                  95      


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 480 


Ala Ala Gly Asn Gly Thr Ser Asn Gly Thr Ser Glu Phe Gly Gly Ala 
                485                 490                 495     


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
            500                 505                 510         


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
        515                 520                 525             


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
    530                 535                 540                 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
545                 550                 555                 560 


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
                565                 570                 575     


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
            580                 585                 590         


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
        595                 600                 605             


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
    610                 615                 620                 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
625                 630                 635                 640 


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly 
                645                 650                 655     


Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
            660                 665                 670         


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
        675                 680                 685             


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
    690                 695                 700                 


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
705                 710                 715                 720 


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
                725                 730                 735     


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
            740                 745                 750         


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
        755                 760                 765             


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
    770                 775                 780                 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
785                 790                 795                 800 


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser 
                805                 810                 815     


Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
            820                 825                 830         


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
        835                 840                 845             


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
    850                 855                 860                 


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
865                 870                 875                 880 


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
                885                 890                 895     


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
            900                 905                 910         


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
        915                 920                 925             


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
    930                 935                 940                 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
945                 950                 955                 960 


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val 
                965                 970                 975     


Ser 
    


<210>  206
<211>  359
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv3M6-EHD2D

<400>  206

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Trp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Leu Lys Met Ala Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val 
    130                 135                 140                 


Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser 
145                 150                 155                 160 


Ser Asp Val Gly Ser Tyr Asn Val Val Ser Trp Tyr Gln Gln His Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Ile Ile Tyr Glu Val Ser Gln Arg Pro Ser 
            180                 185                 190         


Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser 
        195                 200                 205             


Leu Thr Ile Ser Gly Leu Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ser Ser Tyr Ala Gly Ser Ser Ile Phe Val Ile Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Thr Val Leu Ala Ala Ala Gly Gly Ser Gly Gly Asp Phe Thr 
                245                 250                 255     


Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly Gly Gly His 
            260                 265                 270         


Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro 
        275                 280                 285             


Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val Met Asp Val 
    290                 295                 300                 


Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr 
305                 310                 315                 320 


Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser Asp Arg Thr 
                325                 330                 335     


Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu Asp Ser Thr 
            340                 345                 350         


Lys Lys Cys Ala Asp Ser Asn 
        355                 


<210>  207
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  207

Gly Gly Gly Gly Ser Gly Gly Gly 
1               5               


<210>  208
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  208

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  209
<211>  996
<212>  PRT
<213>  Homo sapiens

<400>  209

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Gly Thr Glu 
1               5                   10                  15      


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            20                  25                  30          


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
        35                  40                  45              


Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 
    50                  55                  60                  


Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 
65                  70                  75                  80  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                85                  90                  95      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            100                 105                 110         


Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu 
145                 150                 155                 160 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
                165                 170                 175     


Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            180                 185                 190         


Pro Lys Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn 
225                 230                 235                 240 


Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Arg Ala Ala Ala Gly Gly Ser Gly Gly Asp Lys Thr His Thr Cys Pro 
            260                 265                 270         


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        275                 280                 285             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    290                 295                 300                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
305                 310                 315                 320 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                325                 330                 335     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            340                 345                 350         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        355                 360                 365             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    370                 375                 380                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
385                 390                 395                 400 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                405                 410                 415     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            420                 425                 430         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        435                 440                 445             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    450                 455                 460                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
465                 470                 475                 480 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Gly Gly Ser Gly 
                485                 490                 495     


Gly Gly Ser Ser Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr 
            500                 505                 510         


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
        515                 520                 525             


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
    530                 535                 540                 


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
545                 550                 555                 560 


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
                565                 570                 575     


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
            580                 585                 590         


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
        595                 600                 605             


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
    610                 615                 620                 


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
625                 630                 635                 640 


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
                645                 650                 655     


Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Pro Gln Arg Val 
            660                 665                 670         


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
        675                 680                 685             


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
    690                 695                 700                 


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
705                 710                 715                 720 


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
                725                 730                 735     


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
            740                 745                 750         


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
        755                 760                 765             


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
    770                 775                 780                 


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
785                 790                 795                 800 


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
                805                 810                 815     


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly 
            820                 825                 830         


Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
        835                 840                 845             


Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
    850                 855                 860                 


Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
865                 870                 875                 880 


Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
                885                 890                 895     


Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
            900                 905                 910         


Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
        915                 920                 925             


Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
    930                 935                 940                 


Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
945                 950                 955                 960 


Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
                965                 970                 975     


Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
            980                 985                 990         


Phe Leu Val Gly 
        995     


<210>  210
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  210

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Gly Thr Asp 
1               5                   10                  15      


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Gln Gly Gly Ser Gly Gly Gly Ser Ser Gly Gly Gly Pro Gln Arg 
                245                 250                 255     


Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
            260                 265                 270         


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
        275                 280                 285             


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
    290                 295                 300                 


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
305                 310                 315                 320 


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
                325                 330                 335     


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
            340                 345                 350         


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
        355                 360                 365             


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
    370                 375                 380                 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
385                 390                 395                 400 


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
                405                 410                 415     


Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
            420                 425                 430         


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
        435                 440                 445             


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
    450                 455                 460                 


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
465                 470                 475                 480 


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
                485                 490                 495     


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
            500                 505                 510         


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
        515                 520                 525             


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
    530                 535                 540                 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
545                 550                 555                 560 


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
                565                 570                 575     


Ala Phe Leu Val Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr 
            580                 585                 590         


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
        595                 600                 605             


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
    610                 615                 620                 


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
625                 630                 635                 640 


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
                645                 650                 655     


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
            660                 665                 670         


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
        675                 680                 685             


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
    690                 695                 700                 


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
705                 710                 715                 720 


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
                725                 730                 735     


Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            740                 745     


<210>  211
<211>  997
<212>  PRT
<213>  Homo sapiens

<400>  211

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Gly Thr Glu 
1               5                   10                  15      


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            20                  25                  30          


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
        35                  40                  45              


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
    50                  55                  60                  


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
65                  70                  75                  80  


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
                85                  90                  95      


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
            100                 105                 110         


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
145                 150                 155                 160 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
                165                 170                 175     


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
            180                 185                 190         


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
        195                 200                 205             


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
225                 230                 235                 240 


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys Arg Ala Ala Ala Gly Gly Ser Gly Gly Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
        275                 280                 285             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    290                 295                 300                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
305                 310                 315                 320 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                325                 330                 335     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            340                 345                 350         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        355                 360                 365             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    370                 375                 380                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
385                 390                 395                 400 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                405                 410                 415     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            420                 425                 430         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        435                 440                 445             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    450                 455                 460                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
465                 470                 475                 480 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Ser Ser Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile 
            500                 505                 510         


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
        515                 520                 525             


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
    530                 535                 540                 


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
545                 550                 555                 560 


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
                565                 570                 575     


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
            580                 585                 590         


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
        595                 600                 605             


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
    610                 615                 620                 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
625                 630                 635                 640 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
                645                 650                 655     


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Pro Gln Arg 
            660                 665                 670         


Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
        675                 680                 685             


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
    690                 695                 700                 


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
705                 710                 715                 720 


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
                725                 730                 735     


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
            740                 745                 750         


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
        755                 760                 765             


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
    770                 775                 780                 


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
785                 790                 795                 800 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
                805                 810                 815     


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            820                 825                 830         


Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        835                 840                 845             


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    850                 855                 860                 


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
865                 870                 875                 880 


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                885                 890                 895     


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            900                 905                 910         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        915                 920                 925             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    930                 935                 940                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
945                 950                 955                 960 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                965                 970                 975     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            980                 985                 990         


Ala Phe Leu Val Gly 
        995         


<210>  212
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein scTRAIL3-FLVGGGGSVRERGPQRVA

<400>  212

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        35                  40                  45              


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    50                  55                  60                  


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
65                  70                  75                  80  


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                85                  90                  95      


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            100                 105                 110         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        115                 120                 125             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    130                 135                 140                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
145                 150                 155                 160 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                165                 170                 175     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            180                 185                 190         


Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Val Arg Glu 
        195                 200                 205             


Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
    210                 215                 220                 


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
225                 230                 235                 240 


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
                245                 250                 255     


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
            260                 265                 270         


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
        275                 280                 285             


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
    290                 295                 300                 


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
305                 310                 315                 320 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
                325                 330                 335     


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
            340                 345                 350         


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
        355                 360                 365             


Ala Phe Leu Val Gly Gly Gly Gly Ser Val Arg Glu Arg Gly Pro Gln 
    370                 375                 380                 


Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
385                 390                 395                 400 


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
                405                 410                 415     


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
            420                 425                 430         


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
        435                 440                 445             


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
    450                 455                 460                 


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
465                 470                 475                 480 


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
                485                 490                 495     


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
            500                 505                 510         


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
        515                 520                 525             


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
    530                 535                 540                 


Gly 
545 


<210>  213
<211>  553
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVGGGGSGGGSVRERGPQRVA

<400>  213

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        35                  40                  45              


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    50                  55                  60                  


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
65                  70                  75                  80  


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                85                  90                  95      


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            100                 105                 110         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        115                 120                 125             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    130                 135                 140                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
145                 150                 155                 160 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                165                 170                 175     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            180                 185                 190         


Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Ser Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
    210                 215                 220                 


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
225                 230                 235                 240 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
                245                 250                 255     


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
            260                 265                 270         


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
        275                 280                 285             


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
    290                 295                 300                 


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
305                 310                 315                 320 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
                325                 330                 335     


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
            340                 345                 350         


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
        355                 360                 365             


Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gly Gly Gly 
    370                 375                 380                 


Ser Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
385                 390                 395                 400 


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
                405                 410                 415     


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
            420                 425                 430         


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
        435                 440                 445             


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
    450                 455                 460                 


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
465                 470                 475                 480 


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
                485                 490                 495     


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
            500                 505                 510         


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
        515                 520                 525             


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
    530                 535                 540                 


Ser Phe Phe Gly Ala Phe Leu Val Gly 
545                 550             


<210>  214
<211>  527
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FLVGGGGSQRVA

<400>  214

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        35                  40                  45              


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    50                  55                  60                  


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
65                  70                  75                  80  


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                85                  90                  95      


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            100                 105                 110         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        115                 120                 125             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    130                 135                 140                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
145                 150                 155                 160 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                165                 170                 175     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            180                 185                 190         


Leu Val Gly Gly Gly Gly Ser Gln Arg Val Ala Ala His Ile Thr Gly 
        195                 200                 205             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    210                 215                 220                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
225                 230                 235                 240 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                245                 250                 255     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            260                 265                 270         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        275                 280                 285             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    290                 295                 300                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
305                 310                 315                 320 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                325                 330                 335     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            340                 345                 350         


Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Ser Gln Arg Val 
        355                 360                 365             


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
385                 390                 395                 400 


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
                405                 410                 415     


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
            420                 425                 430         


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
        435                 440                 445             


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
    450                 455                 460                 


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
465                 470                 475                 480 


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
                485                 490                 495     


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
            500                 505                 510         


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
        515                 520                 525         


<210>  215
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVGGGGSGGGSQRVA

<400>  215

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        35                  40                  45              


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    50                  55                  60                  


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
65                  70                  75                  80  


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                85                  90                  95      


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            100                 105                 110         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        115                 120                 125             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    130                 135                 140                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
145                 150                 155                 160 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                165                 170                 175     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            180                 185                 190         


Leu Val Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Arg Val Ala Ala 
        195                 200                 205             


His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn 
    210                 215                 220                 


Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser 
225                 230                 235                 240 


Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly 
                245                 250                 255     


Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr 
            260                 265                 270         


Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys 
        275                 280                 285             


Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile 
    290                 295                 300                 


Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu 
305                 310                 315                 320 


Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu 
                325                 330                 335     


Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met 
            340                 345                 350         


Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Ser Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
    370                 375                 380                 


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
385                 390                 395                 400 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
                405                 410                 415     


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
            420                 425                 430         


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
        435                 440                 445             


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
    450                 455                 460                 


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
465                 470                 475                 480 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
                485                 490                 495     


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
            500                 505                 510         


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
        515                 520                 525             


Phe Gly Ala Phe Leu Val Gly 
    530                 535 


<210>  216
<211>  525
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVGGPQRVA

<400>  216

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Leu Val Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        195                 200                 205             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    210                 215                 220                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
225                 230                 235                 240 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                245                 250                 255     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            260                 265                 270         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        275                 280                 285             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    290                 295                 300                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
305                 310                 315                 320 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                325                 330                 335     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            340                 345                 350         


Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Pro Gln Arg Val Ala Ala 
        355                 360                 365             


His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn 
    370                 375                 380                 


Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser 
385                 390                 395                 400 


Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly 
                405                 410                 415     


Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr 
            420                 425                 430         


Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys 
        435                 440                 445             


Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile 
    450                 455                 460                 


Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu 
465                 470                 475                 480 


Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu 
                485                 490                 495     


Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met 
            500                 505                 510         


Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
        515                 520                 525 


<210>  217
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVGGGPQRVA

<400>  217

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Leu Val Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr 
        195                 200                 205             


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
    210                 215                 220                 


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
225                 230                 235                 240 


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
                245                 250                 255     


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
            260                 265                 270         


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
        275                 280                 285             


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
    290                 295                 300                 


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
305                 310                 315                 320 


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
                325                 330                 335     


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
            340                 345                 350         


Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Pro Gln Arg Val 
        355                 360                 365             


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
385                 390                 395                 400 


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
                405                 410                 415     


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
            420                 425                 430         


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
        435                 440                 445             


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
    450                 455                 460                 


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
465                 470                 475                 480 


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
                485                 490                 495     


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
            500                 505                 510         


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
        515                 520                 525     


<210>  218
<211>  529
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVGGGGPQRVA

<400>  218

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Leu Val Gly Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile 
        195                 200                 205             


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
    210                 215                 220                 


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
225                 230                 235                 240 


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
                245                 250                 255     


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
            260                 265                 270         


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
        275                 280                 285             


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
    290                 295                 300                 


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
305                 310                 315                 320 


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
                325                 330                 335     


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
            340                 345                 350         


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Gly Pro Gln 
        355                 360                 365             


Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
    370                 375                 380                 


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
385                 390                 395                 400 


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
                405                 410                 415     


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
            420                 425                 430         


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
        435                 440                 445             


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
    450                 455                 460                 


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
465                 470                 475                 480 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
                485                 490                 495     


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
            500                 505                 510         


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
        515                 520                 525             


Gly 
    


<210>  219
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  219

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        35                  40                  45              


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    50                  55                  60                  


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
65                  70                  75                  80  


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                85                  90                  95      


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            100                 105                 110         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        115                 120                 125             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    130                 135                 140                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
145                 150                 155                 160 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                165                 170                 175     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            180                 185                 190         


Leu Val Gly Gly Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 
        195                 200                 205             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    210                 215                 220                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
225                 230                 235                 240 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                245                 250                 255     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            260                 265                 270         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        275                 280                 285             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    290                 295                 300                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
305                 310                 315                 320 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                325                 330                 335     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            340                 345                 350         


Gly Ala Phe Leu Val Gly Gly Gln Arg Val Ala Ala His Ile Thr Gly 
        355                 360                 365             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    370                 375                 380                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
385                 390                 395                 400 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                405                 410                 415     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            420                 425                 430         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        435                 440                 445             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    450                 455                 460                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
465                 470                 475                 480 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                485                 490                 495     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            500                 505                 510         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        515                 520     


<210>  220
<211>  518
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVGGRVA

<400>  220

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        35                  40                  45              


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    50                  55                  60                  


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
65                  70                  75                  80  


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                85                  90                  95      


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            100                 105                 110         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        115                 120                 125             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    130                 135                 140                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
145                 150                 155                 160 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                165                 170                 175     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
            180                 185                 190         


Val Gly Gly Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser 
        195                 200                 205             


Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg 
    210                 215                 220                 


Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser 
225                 230                 235                 240 


Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe 
                245                 250                 255     


Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys 
            260                 265                 270         


Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr 
        275                 280                 285             


Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser 
    290                 295                 300                 


Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly 
305                 310                 315                 320 


Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr 
                325                 330                 335     


Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala 
            340                 345                 350         


Phe Leu Val Gly Gly Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 
        355                 360                 365             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    370                 375                 380                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
385                 390                 395                 400 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                405                 410                 415     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            420                 425                 430         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        435                 440                 445             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    450                 455                 460                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
465                 470                 475                 480 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                485                 490                 495     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            500                 505                 510         


Gly Ala Phe Leu Val Gly 
        515             


<210>  221
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FLVGGVA

<400>  221

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
            180                 185                 190         


Gly Gly Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
            340                 345                 350         


Val Gly Gly Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Leu Val Gly 
        515 


<210>  222
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVGGGA

<400>  222

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Gly Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
            180                 185                 190         


Gly Gly Gly Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
            340                 345                 350         


Val Gly Gly Gly Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Leu Val Gly 
        515 


<210>  223
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLGGGA

<400>  223

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
        35                  40                  45              


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
    50                  55                  60                  


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
65                  70                  75                  80  


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
                85                  90                  95      


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
            100                 105                 110         


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
        115                 120                 125             


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
    130                 135                 140                 


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
145                 150                 155                 160 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
                165                 170                 175     


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Gly Gly 
            180                 185                 190         


Gly Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
        195                 200                 205             


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
    210                 215                 220                 


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
225                 230                 235                 240 


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
                245                 250                 255     


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
            260                 265                 270         


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
        275                 280                 285             


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
    290                 295                 300                 


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
305                 310                 315                 320 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
                325                 330                 335     


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Gly Gly 
            340                 345                 350         


Gly Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
        355                 360                 365             


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
    370                 375                 380                 


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
385                 390                 395                 400 


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
                405                 410                 415     


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
            420                 425                 430         


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
        435                 440                 445             


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
    450                 455                 460                 


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
465                 470                 475                 480 


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
                485                 490                 495     


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            500                 505                 510         


<210>  224
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVGGIA

<400>  224

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
            180                 185                 190         


Gly Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
            340                 345                 350         


Val Gly Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Leu Val Gly 
        515 


<210>  225
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVGGAA

<400>  225

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
            180                 185                 190         


Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
            340                 345                 350         


Val Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Leu Val Gly 
        515 


<210>  226
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FAVGGAA

<400>  226

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val 
            180                 185                 190         


Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala 
            340                 345                 350         


Val Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Ala Val Gly 
        515 


<210>  227
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FAVSGAA

<400>  227

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val 
            180                 185                 190         


Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala 
            340                 345                 350         


Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Ala Val Ser 
        515 


<210>  228
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FAVGGIA

<400>  228

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val 
            180                 185                 190         


Gly Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala 
            340                 345                 350         


Val Gly Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Ala Val Gly 
        515 


<210>  229
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FIVGGIA

<400>  229

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ile Val 
            180                 185                 190         


Gly Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ile 
            340                 345                 350         


Val Gly Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Ile Val Gly 
        515 


<210>  230
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVSGIA

<400>  230

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
            180                 185                 190         


Ser Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
            340                 345                 350         


Val Ser Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Leu Val Ser 
        515 


<210>  231
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FIVSGIA

<400>  231

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ile Val 
            180                 185                 190         


Ser Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ile 
            340                 345                 350         


Val Ser Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Ile Val Ser 
        515 


<210>  232
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FAVSGIA

<400>  232

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val 
            180                 185                 190         


Ser Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala 
            340                 345                 350         


Val Ser Gly Ile Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Ala Val Ser 
        515 


<210>  233
<211>  515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scTRAIL3-FLVGGVA

<400>  233

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Asp Asp Tyr Lys Asp Asp Asp Asp Lys Glu Phe Gly 
            20                  25                  30          


Gly Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
        35                  40                  45              


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
    50                  55                  60                  


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
65                  70                  75                  80  


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
                85                  90                  95      


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
            100                 105                 110         


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
        115                 120                 125             


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
    130                 135                 140                 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
145                 150                 155                 160 


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
                165                 170                 175     


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
            180                 185                 190         


Gly Gly Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
        195                 200                 205             


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
    210                 215                 220                 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
225                 230                 235                 240 


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
                245                 250                 255     


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
            260                 265                 270         


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
        275                 280                 285             


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
    290                 295                 300                 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
305                 310                 315                 320 


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
                325                 330                 335     


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
            340                 345                 350         


Val Gly Gly Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
        355                 360                 365             


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
    370                 375                 380                 


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
385                 390                 395                 400 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
                405                 410                 415     


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
            420                 425                 430         


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
        435                 440                 445             


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
    450                 455                 460                 


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
465                 470                 475                 480 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
                485                 490                 495     


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
            500                 505                 510         


Leu Val Gly 
        515 


<210>  234
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein Db-scTRAIL3

<400>  234

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Gly Thr Glu 
1               5                   10                  15      


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            20                  25                  30          


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
        35                  40                  45              


Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 
    50                  55                  60                  


Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 
65                  70                  75                  80  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                85                  90                  95      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            100                 105                 110         


Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Glu 
            180                 185                 190         


Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
            260                 265                 270         


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
        275                 280                 285             


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
    290                 295                 300                 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
305                 310                 315                 320 


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
                325                 330                 335     


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
            340                 345                 350         


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
        355                 360                 365             


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
    370                 375                 380                 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
385                 390                 395                 400 


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
                405                 410                 415     


Leu Val Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
            420                 425                 430         


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
        435                 440                 445             


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
    450                 455                 460                 


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
465                 470                 475                 480 


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
                485                 490                 495     


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
            500                 505                 510         


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
        515                 520                 525             


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
    530                 535                 540                 


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
545                 550                 555                 560 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
                565                 570                 575     


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Pro Gln Arg Val Ala Ala 
            580                 585                 590         


His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn 
        595                 600                 605             


Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser 
    610                 615                 620                 


Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly 
625                 630                 635                 640 


Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr 
                645                 650                 655     


Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys 
            660                 665                 670         


Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile 
        675                 680                 685             


Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu 
    690                 695                 700                 


Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu 
705                 710                 715                 720 


Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met 
                725                 730                 735     


Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            740                 745                 


<210>  235
<211>  749
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein dsDb-scTRAIL3

<400>  235

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Gly Thr Glu 
1               5                   10                  15      


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            20                  25                  30          


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
        35                  40                  45              


Val His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Leu Gly 
    50                  55                  60                  


Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 
65                  70                  75                  80  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                85                  90                  95      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            100                 105                 110         


Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Lys Tyr Ala Ser Glu 
            180                 185                 190         


Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Cys Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
            260                 265                 270         


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
        275                 280                 285             


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
    290                 295                 300                 


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
305                 310                 315                 320 


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
                325                 330                 335     


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
            340                 345                 350         


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
        355                 360                 365             


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
    370                 375                 380                 


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
385                 390                 395                 400 


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
                405                 410                 415     


Leu Val Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr 
            420                 425                 430         


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
        435                 440                 445             


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
    450                 455                 460                 


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
465                 470                 475                 480 


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
                485                 490                 495     


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
            500                 505                 510         


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
        515                 520                 525             


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
    530                 535                 540                 


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
545                 550                 555                 560 


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
                565                 570                 575     


Phe Phe Gly Ala Phe Leu Val Gly Gly Gly Pro Gln Arg Val Ala Ala 
            580                 585                 590         


His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn 
        595                 600                 605             


Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser 
    610                 615                 620                 


Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly 
625                 630                 635                 640 


Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr 
                645                 650                 655     


Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys 
            660                 665                 670         


Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile 
        675                 680                 685             


Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu 
    690                 695                 700                 


Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu 
705                 710                 715                 720 


Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met 
                725                 730                 735     


Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
            740                 745                 


<210>  236
<211>  875
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein scFv-EHD2-scTRAIL3

<400>  236

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly Ser Gly Thr Glu 
1               5                   10                  15      


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            20                  25                  30          


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
        35                  40                  45              


Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly 
    50                  55                  60                  


Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 
65                  70                  75                  80  


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                85                  90                  95      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            100                 105                 110         


Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu 
145                 150                 155                 160 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
                165                 170                 175     


Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
            180                 185                 190         


Pro Lys Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro 
        195                 200                 205             


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
    210                 215                 220                 


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn 
225                 230                 235                 240 


Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
                245                 250                 255     


Arg Ala Ala Ala Gly Gly Ser Gly Gly Asp Phe Thr Pro Pro Thr Val 
            260                 265                 270         


Lys Ile Leu Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr 
        275                 280                 285             


Ile Gln Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn 
    290                 295                 300                 


Ile Thr Trp Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr 
305                 310                 315                 320 


Ala Ser Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu 
                325                 330                 335     


Thr Leu Ser Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln 
            340                 345                 350         


Val Thr Tyr Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala 
        355                 360                 365             


Asp Ser Asn Gly Gly Ser Gly Gly Ala Ser Ser Gly Gly Gly Pro Gln 
    370                 375                 380                 


Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
385                 390                 395                 400 


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
                405                 410                 415     


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
            420                 425                 430         


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
        435                 440                 445             


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
    450                 455                 460                 


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
465                 470                 475                 480 


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
                485                 490                 495     


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
            500                 505                 510         


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
        515                 520                 525             


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu Val 
    530                 535                 540                 


Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly 
545                 550                 555                 560 


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
                565                 570                 575     


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
            580                 585                 590         


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
        595                 600                 605             


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
    610                 615                 620                 


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
625                 630                 635                 640 


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
                645                 650                 655     


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
            660                 665                 670         


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
        675                 680                 685             


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
    690                 695                 700                 


Gly Ala Phe Leu Val Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile 
705                 710                 715                 720 


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
                725                 730                 735     


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
            740                 745                 750         


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
        755                 760                 765             


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
    770                 775                 780                 


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
785                 790                 795                 800 


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
                805                 810                 815     


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
            820                 825                 830         


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
        835                 840                 845             


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
    850                 855                 860                 


Glu Ala Ser Phe Phe Gly Ala Phe Leu Val Gly 
865                 870                 875 


<210>  237
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion of scTRAIL3-FAVSGAA

<400>  237

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  238
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  238

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  239
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  239

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  240
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  240

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Ser Tyr 
            20                  25                  30          


Asn Val Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Gln Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      


Ser Ile Phe Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110     


<210>  241
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  241

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Gly Trp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Leu Lys Met Ala Thr Ile Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  242
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ala 
            20                  25                  30          


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        35                  40                  45              


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asn Tyr 
    50                  55                  60                  


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
65                  70                  75                  80  


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
                85                  90                  95      


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
            100                 105                 110         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
145                 150                 155                 160 


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
            180                 185                 190         


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
    210                 215                 220                 


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
225                 230                 235                 240 


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    370                 375                 380                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
385                 390                 395                 400 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        435                 440                 445             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    450                 455                 460                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 480 


<210>  243
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
            100                 105                 110         


Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  244
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion protein hu225 IgG light chain-scTRAIL3-FAVSGAA

<400>  244

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser 
        35                  40                  45              


Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
            100                 105                 110         


Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Ala Ala Gly Asn Gly Thr 
225                 230                 235                 240 


Ser Asn Gly Thr Ser Glu Phe Gly Gly Ala Ala Ala His Ile Thr Gly 
                245                 250                 255     


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
            260                 265                 270         


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
        275                 280                 285             


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
    290                 295                 300                 


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
305                 310                 315                 320 


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
                325                 330                 335     


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
            340                 345                 350         


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
        355                 360                 365             


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
    370                 375                 380                 


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
385                 390                 395                 400 


Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr 
                405                 410                 415     


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
            420                 425                 430         


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
        435                 440                 445             


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
    450                 455                 460                 


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
465                 470                 475                 480 


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
                485                 490                 495     


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
            500                 505                 510         


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
        515                 520                 525             


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
    530                 535                 540                 


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
545                 550                 555                 560 


Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile 
                565                 570                 575     


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
            580                 585                 590         


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
        595                 600                 605             


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
    610                 615                 620                 


Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe 
625                 630                 635                 640 


Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met 
                645                 650                 655     


Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu 
            660                 665                 670         


Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly 
        675                 680                 685             


Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp 
    690                 695                 700                 


Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His 
705                 710                 715                 720 


Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser 
                725                 730     


<210>  245
<211>  762
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FAVSGAA-Fc

<400>  245

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        195                 200                 205             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    210                 215                 220                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
225                 230                 235                 240 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                245                 250                 255     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            260                 265                 270         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        275                 280                 285             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    290                 295                 300                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
305                 310                 315                 320 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                325                 330                 335     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            340                 345                 350         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        355                 360                 365             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    370                 375                 380                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
385                 390                 395                 400 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                405                 410                 415     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            420                 425                 430         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        435                 440                 445             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    450                 455                 460                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
465                 470                 475                 480 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                485                 490                 495     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            500                 505                 510         


Phe Gly Ala Phe Ala Val Ser Gly Ser Gly Asn Gly Thr Ser Asn Gly 
        515                 520                 525             


Thr Ser Gly Ser Ser Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            660                 665                 670         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760         


<210>  246
<211>  760
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc-scTRAIL3-FAVSGAA

<400>  246

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Gln Gly Ser Gly Asn Gly Thr Ser Asn Gly Thr 
            260                 265                 270         


Ser Gly Ser Ser Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        275                 280                 285             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    290                 295                 300                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
305                 310                 315                 320 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                325                 330                 335     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            340                 345                 350         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        355                 360                 365             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    370                 375                 380                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
385                 390                 395                 400 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                405                 410                 415     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            420                 425                 430         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        435                 440                 445             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    450                 455                 460                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
465                 470                 475                 480 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                485                 490                 495     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            500                 505                 510         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        515                 520                 525             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    530                 535                 540                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
545                 550                 555                 560 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                565                 570                 575     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            580                 585                 590         


Phe Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr 
        595                 600                 605             


Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys 
    610                 615                 620                 


Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His 
625                 630                 635                 640 


Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His 
                645                 650                 655     


Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln 
            660                 665                 670         


Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr 
        675                 680                 685             


Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser 
    690                 695                 700                 


Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser 
705                 710                 715                 720 


Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe 
                725                 730                 735     


Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser 
            740                 745                 750         


Phe Phe Gly Ala Phe Ala Val Ser 
        755                 760 


<210>  247
<211>  1260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FAVSGAA-Fc-scTRAIL3-FAVSGAA

<400>  247

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        195                 200                 205             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    210                 215                 220                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
225                 230                 235                 240 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                245                 250                 255     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            260                 265                 270         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        275                 280                 285             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    290                 295                 300                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
305                 310                 315                 320 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                325                 330                 335     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            340                 345                 350         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        355                 360                 365             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    370                 375                 380                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
385                 390                 395                 400 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                405                 410                 415     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            420                 425                 430         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        435                 440                 445             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    450                 455                 460                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
465                 470                 475                 480 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                485                 490                 495     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            500                 505                 510         


Phe Gly Ala Phe Ala Val Ser Gly Ser Gly Asn Gly Thr Ser Asn Gly 
        515                 520                 525             


Thr Ser Gly Ser Ser Arg Thr Asp Lys Thr His Thr Cys Pro Pro Cys 
    530                 535                 540                 


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
545                 550                 555                 560 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                565                 570                 575     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            580                 585                 590         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        595                 600                 605             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    610                 615                 620                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
625                 630                 635                 640 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                645                 650                 655     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            660                 665                 670         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        675                 680                 685             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    690                 695                 700                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
705                 710                 715                 720 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                725                 730                 735     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            740                 745                 750         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Gly Ser Gly Asn Gly Thr 
        755                 760                 765             


Ser Asn Gly Thr Ser Gly Ser Ser Gly Gly Ala Ala Ala His Ile Thr 
    770                 775                 780                 


Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn 
785                 790                 795                 800 


Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser 
                805                 810                 815     


Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val 
            820                 825                 830         


Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg 
        835                 840                 845             


Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val 
    850                 855                 860                 


Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met 
865                 870                 875                 880 


Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu 
                885                 890                 895     


Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg 
            900                 905                 910         


Ile Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu 
        915                 920                 925             


Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile 
    930                 935                 940                 


Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys 
945                 950                 955                 960 


Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg 
                965                 970                 975     


Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu 
            980                 985                 990         


Val Ile His Glu Lys Gly Phe Tyr  Tyr Ile Tyr Ser Gln  Thr Tyr Phe 
        995                 1000                 1005             


Arg Phe  Gln Glu Glu Ile Lys  Glu Asn Thr Lys Asn  Asp Lys Gln 
    1010                 1015                 1020             


Met Val  Gln Tyr Ile Tyr Lys  Tyr Thr Ser Tyr Pro  Asp Pro Ile 
    1025                 1030                 1035             


Leu Leu  Met Lys Ser Ala Arg  Asn Ser Cys Trp Ser  Lys Asp Ala 
    1040                 1045                 1050             


Glu Tyr  Gly Leu Tyr Ser Ile  Tyr Gln Gly Gly Ile  Phe Glu Leu 
    1055                 1060                 1065             


Lys Glu  Asn Asp Arg Ile Phe  Val Ser Val Thr Asn  Glu His Leu 
    1070                 1075                 1080             


Ile Asp  Met Asp His Glu Ala  Ser Phe Phe Gly Ala  Phe Ala Val 
    1085                 1090                 1095             


Ser Gly  Ala Ala Ala His Ile  Thr Gly Thr Arg Gly  Arg Ser Asn 
    1100                 1105                 1110             


Thr Leu  Ser Ser Pro Asn Ser  Lys Asn Glu Lys Ala  Leu Gly Arg 
    1115                 1120                 1125             


Lys Ile  Asn Ser Trp Glu Ser  Ser Arg Ser Gly His  Ser Phe Leu 
    1130                 1135                 1140             


Ser Asn  Leu His Leu Arg Asn  Gly Glu Leu Val Ile  His Glu Lys 
    1145                 1150                 1155             


Gly Phe  Tyr Tyr Ile Tyr Ser  Gln Thr Tyr Phe Arg  Phe Gln Glu 
    1160                 1165                 1170             


Glu Ile  Lys Glu Asn Thr Lys  Asn Asp Lys Gln Met  Val Gln Tyr 
    1175                 1180                 1185             


Ile Tyr  Lys Tyr Thr Ser Tyr  Pro Asp Pro Ile Leu  Leu Met Lys 
    1190                 1195                 1200             


Ser Ala  Arg Asn Ser Cys Trp  Ser Lys Asp Ala Glu  Tyr Gly Leu 
    1205                 1210                 1215             


Tyr Ser  Ile Tyr Gln Gly Gly  Ile Phe Glu Leu Lys  Glu Asn Asp 
    1220                 1225                 1230             


Arg Ile  Phe Val Ser Val Thr  Asn Glu His Leu Ile  Asp Met Asp 
    1235                 1240                 1245             


His Glu  Ala Ser Phe Phe Gly  Ala Phe Ala Val Ser  
    1250                 1255                 1260 


<210>  248
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FAVSGAA-0-Fc

<400>  248

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        195                 200                 205             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    210                 215                 220                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
225                 230                 235                 240 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                245                 250                 255     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            260                 265                 270         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        275                 280                 285             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    290                 295                 300                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
305                 310                 315                 320 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                325                 330                 335     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            340                 345                 350         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        355                 360                 365             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    370                 375                 380                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
385                 390                 395                 400 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                405                 410                 415     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            420                 425                 430         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        435                 440                 445             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    450                 455                 460                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
465                 470                 475                 480 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                485                 490                 495     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            500                 505                 510         


Phe Gly Ala Phe Ala Val Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
        515                 520                 525             


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
    530                 535                 540                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
545                 550                 555                 560 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                565                 570                 575     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            580                 585                 590         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        595                 600                 605             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    610                 615                 620                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
625                 630                 635                 640 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                645                 650                 655     


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            660                 665                 670         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        675                 680                 685             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    690                 695                 700                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
705                 710                 715                 720 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                725                 730                 735     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745     


<210>  249
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FAVSGAA-5 G/S-Fc

<400>  249

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        195                 200                 205             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    210                 215                 220                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
225                 230                 235                 240 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                245                 250                 255     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            260                 265                 270         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        275                 280                 285             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    290                 295                 300                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
305                 310                 315                 320 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                325                 330                 335     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            340                 345                 350         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        355                 360                 365             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    370                 375                 380                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
385                 390                 395                 400 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                405                 410                 415     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            420                 425                 430         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        435                 440                 445             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    450                 455                 460                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
465                 470                 475                 480 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                485                 490                 495     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            500                 505                 510         


Phe Gly Ala Phe Ala Val Ser Gly Gly Ser Gly Gly Asp Lys Thr His 
        515                 520                 525             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    530                 535                 540                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
545                 550                 555                 560 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                565                 570                 575     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            580                 585                 590         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        595                 600                 605             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    610                 615                 620                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
625                 630                 635                 640 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                645                 650                 655     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            660                 665                 670         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        675                 680                 685             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    690                 695                 700                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
705                 710                 715                 720 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                725                 730                 735     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745                 750     


<210>  250
<211>  756
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FAVSGAA-10 G/S-Fc

<400>  250

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        195                 200                 205             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    210                 215                 220                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
225                 230                 235                 240 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                245                 250                 255     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            260                 265                 270         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        275                 280                 285             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    290                 295                 300                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
305                 310                 315                 320 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                325                 330                 335     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            340                 345                 350         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        355                 360                 365             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    370                 375                 380                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
385                 390                 395                 400 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                405                 410                 415     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            420                 425                 430         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        435                 440                 445             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    450                 455                 460                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
465                 470                 475                 480 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                485                 490                 495     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            500                 505                 510         


Phe Gly Ala Phe Ala Val Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    530                 535                 540                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
545                 550                 555                 560 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                565                 570                 575     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            580                 585                 590         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        595                 600                 605             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    610                 615                 620                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
625                 630                 635                 640 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                645                 650                 655     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            660                 665                 670         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        675                 680                 685             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    690                 695                 700                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
705                 710                 715                 720 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                725                 730                 735     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            740                 745                 750         


Ser Pro Gly Lys 
        755     


<210>  251
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FAVSGAA-15 G/S-Fc

<400>  251

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        195                 200                 205             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    210                 215                 220                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
225                 230                 235                 240 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                245                 250                 255     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            260                 265                 270         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        275                 280                 285             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    290                 295                 300                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
305                 310                 315                 320 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                325                 330                 335     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            340                 345                 350         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        355                 360                 365             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    370                 375                 380                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
385                 390                 395                 400 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                405                 410                 415     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            420                 425                 430         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        435                 440                 445             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    450                 455                 460                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
465                 470                 475                 480 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                485                 490                 495     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            500                 505                 510         


Phe Gly Ala Phe Ala Val Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    530                 535                 540                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
545                 550                 555                 560 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                565                 570                 575     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            580                 585                 590         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        595                 600                 605             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    610                 615                 620                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
625                 630                 635                 640 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                645                 650                 655     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            660                 665                 670         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        675                 680                 685             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    690                 695                 700                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
705                 710                 715                 720 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                725                 730                 735     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            740                 745                 750         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760     


<210>  252
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FAVSGAA-20 G/S-Fc

<400>  252

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        195                 200                 205             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    210                 215                 220                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
225                 230                 235                 240 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                245                 250                 255     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            260                 265                 270         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        275                 280                 285             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    290                 295                 300                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
305                 310                 315                 320 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                325                 330                 335     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            340                 345                 350         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        355                 360                 365             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    370                 375                 380                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
385                 390                 395                 400 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                405                 410                 415     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            420                 425                 430         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        435                 440                 445             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    450                 455                 460                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
465                 470                 475                 480 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                485                 490                 495     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            500                 505                 510         


Phe Gly Ala Phe Ala Val Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Lys Thr His Thr 
    530                 535                 540                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
545                 550                 555                 560 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                565                 570                 575     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            580                 585                 590         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        595                 600                 605             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    610                 615                 620                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
625                 630                 635                 640 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                645                 650                 655     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            660                 665                 670         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        675                 680                 685             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    690                 695                 700                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
705                 710                 715                 720 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                725                 730                 735     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            740                 745                 750         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760                 765     


<210>  253
<211>  771
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FAVSGAA-25 G/S-Fc

<400>  253

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        195                 200                 205             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    210                 215                 220                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
225                 230                 235                 240 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                245                 250                 255     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            260                 265                 270         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        275                 280                 285             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    290                 295                 300                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
305                 310                 315                 320 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                325                 330                 335     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            340                 345                 350         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        355                 360                 365             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    370                 375                 380                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
385                 390                 395                 400 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                405                 410                 415     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            420                 425                 430         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        435                 440                 445             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    450                 455                 460                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
465                 470                 475                 480 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                485                 490                 495     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            500                 505                 510         


Phe Gly Ala Phe Ala Val Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        515                 520                 525             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
545                 550                 555                 560 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                565                 570                 575     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            580                 585                 590         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        595                 600                 605             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    610                 615                 620                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
625                 630                 635                 640 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                645                 650                 655     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            660                 665                 670         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        675                 680                 685             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    690                 695                 700                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
705                 710                 715                 720 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                725                 730                 735     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            740                 745                 750         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        755                 760                 765             


Pro Gly Lys 
    770     


<210>  254
<211>  779
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scTRAIL3-FAVSGAA-"W"-Fc

<400>  254

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Gly Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg 
        35                  40                  45              


Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly 
    50                  55                  60                  


Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu 
65                  70                  75                  80  


Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly 
                85                  90                  95      


Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile 
            100                 105                 110         


Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys 
        115                 120                 125             


Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn 
    130                 135                 140                 


Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln 
145                 150                 155                 160 


Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val 
                165                 170                 175     


Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly 
            180                 185                 190         


Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly 
        195                 200                 205             


Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu 
    210                 215                 220                 


Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe 
225                 230                 235                 240 


Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys 
                245                 250                 255     


Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu 
            260                 265                 270         


Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr 
        275                 280                 285             


Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg 
    290                 295                 300                 


Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr 
305                 310                 315                 320 


Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser 
                325                 330                 335     


Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe 
            340                 345                 350         


Gly Ala Phe Ala Val Ser Gly Ala Ala Ala His Ile Thr Gly Thr Arg 
        355                 360                 365             


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
    370                 375                 380                 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
385                 390                 395                 400 


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
                405                 410                 415     


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
            420                 425                 430         


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
        435                 440                 445             


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
    450                 455                 460                 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
465                 470                 475                 480 


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
                485                 490                 495     


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
            500                 505                 510         


Phe Gly Ala Phe Ala Val Ser Gly Gly Ser Gly Glu Ala Ala Ala Lys 
        515                 520                 525             


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
    530                 535                 540                 


Ala Ala Ala Lys Gly Ser Gly Gly Asp Lys Thr His Thr Cys Pro Pro 
545                 550                 555                 560 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                565                 570                 575     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            580                 585                 590         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        595                 600                 605             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    610                 615                 620                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
625                 630                 635                 640 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                645                 650                 655     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            660                 665                 670         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        675                 680                 685             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    690                 695                 700                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
705                 710                 715                 720 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                725                 730                 735     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            740                 745                 750         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        755                 760                 765             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 


<210>  255
<211>  769
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Db anti-FAP-Glyco-scTRAIL3-FAVSGAA

<400>  255

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Leu Glu Ala Ser Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
            20                  25                  30          


Thr Gly Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
        35                  40                  45              


Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
    50                  55                  60                  


Glu Asn Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu 
65                  70                  75                  80  


Trp Met Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn Glu 
                85                  90                  95      


Lys Phe Lys Asp Arg Val Thr Met Thr Ala Asp Thr Ser Thr Ser Thr 
            100                 105                 110         


Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
        115                 120                 125             


Tyr Cys Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr Trp 
    130                 135                 140                 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser Ala 
            180                 185                 190         


Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        195                 200                 205             


Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
225                 230                 235                 240 


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu 
                245                 250                 255     


Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            260                 265                 270         


Ala Ala Gly Asn Gly Thr Ser Asn Gly Thr Ser Glu Phe Gly Gly Ala 
        275                 280                 285             


Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser 
    290                 295                 300                 


Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp 
305                 310                 315                 320 


Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg 
                325                 330                 335     


Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser 
            340                 345                 350         


Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn 
        355                 360                 365             


Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp 
    370                 375                 380                 


Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp 
385                 390                 395                 400 


Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu 
                405                 410                 415     


Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu Ile 
            420                 425                 430         


Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser Gly 
        435                 440                 445             


Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser 
    450                 455                 460                 


Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser 
465                 470                 475                 480 


Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu 
                485                 490                 495     


Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr 
            500                 505                 510         


Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys 
        515                 520                 525             


Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro 
    530                 535                 540                 


Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys 
545                 550                 555                 560 


Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu 
                565                 570                 575     


Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His Leu 
            580                 585                 590         


Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val Ser 
        595                 600                 605             


Gly Ala Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu 
    610                 615                 620                 


Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn 
625                 630                 635                 640 


Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu His 
                645                 650                 655     


Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile 
            660                 665                 670         


Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr 
        675                 680                 685             


Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr 
    690                 695                 700                 


Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser 
705                 710                 715                 720 


Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe 
                725                 730                 735     


Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu His 
            740                 745                 750         


Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Ala Val 
        755                 760                 765             


Ser 
    


<210>  256
<211>  1020
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv36-Fc- scTRAIL3-FLVGGGPQRVA

<400>  256

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Lys Asp Asp Asp Asp Lys Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Thr Gln Val Gln Leu Lys Gln Ser Gly Ala Glu Leu Val Lys 
        35                  40                  45              


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
    50                  55                  60                  


Thr Glu Asn Ile Ile His Trp Val Lys Gln Arg Ser Gly Gln Gly Leu 
65                  70                  75                  80  


Glu Trp Ile Gly Trp Phe His Pro Gly Ser Gly Ser Ile Lys Tyr Asn 
                85                  90                  95      


Glu Lys Phe Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
            100                 105                 110         


Thr Val Tyr Met Glu Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val 
        115                 120                 125             


Tyr Phe Cys Ala Arg His Gly Gly Thr Gly Arg Gly Ala Met Asp Tyr 
    130                 135                 140                 


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Ser Ala Gln Ile Leu Met Thr Gln Ser 
                165                 170                 175     


Pro Ala Ser Ser Val Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 
            180                 185                 190         


Arg Ala Ser Lys Ser Val Ser Thr Ser Ala Tyr Ser Tyr Met His Trp 
        195                 200                 205             


Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala 
    210                 215                 220                 


Ser Asn Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Gly Ser Gly Ser 
225                 230                 235                 240 


Gly Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala 
                245                 250                 255     


Ala Thr Tyr Tyr Cys Gln His Ser Arg Glu Leu Pro Tyr Thr Phe Gly 
            260                 265                 270         


Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Ala Ala Gly Gly Ser Gly 
        275                 280                 285             


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    290                 295                 300                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
305                 310                 315                 320 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                325                 330                 335     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            340                 345                 350         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        355                 360                 365             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    370                 375                 380                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
385                 390                 395                 400 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                405                 410                 415     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            420                 425                 430         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        435                 440                 445             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    450                 455                 460                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
465                 470                 475                 480 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                485                 490                 495     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            500                 505                 510         


Ser Pro Gly Gln Gly Gly Ser Gly Gly Gly Ser Ser Gly Gly Gly Pro 
        515                 520                 525             


Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr 
    530                 535                 540                 


Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile 
545                 550                 555                 560 


Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn Leu 
                565                 570                 575     


His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr Tyr 
            580                 585                 590         


Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn 
        595                 600                 605             


Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser 
    610                 615                 620                 


Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys Trp 
625                 630                 635                 640 


Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile 
                645                 650                 655     


Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn Glu 
            660                 665                 670         


His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe Leu 
        675                 680                 685             


Val Gly Gly Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg 
    690                 695                 700                 


Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala 
705                 710                 715                 720 


Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser 
                725                 730                 735     


Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu 
            740                 745                 750         


Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu 
        755                 760                 765             


Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile 
    770                 775                 780                 


Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala 
785                 790                 795                 800 


Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile 
                805                 810                 815     


Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val 
            820                 825                 830         


Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe 
        835                 840                 845             


Phe Gly Ala Phe Leu Val Gly Gly Gly Pro Gln Arg Val Ala Ala His 
    850                 855                 860                 


Ile Thr Gly Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser 
865                 870                 875                 880 


Lys Asn Glu Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser 
                885                 890                 895     


Arg Ser Gly His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu 
            900                 905                 910         


Leu Val Ile His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr 
        915                 920                 925             


Phe Arg Phe Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln 
    930                 935                 940                 


Met Val Gln Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu 
945                 950                 955                 960 


Leu Met Lys Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr 
                965                 970                 975     


Gly Leu Tyr Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn 
            980                 985                 990         


Asp Arg Ile Phe Val Ser Val Thr  Asn Glu His Leu Ile  Asp Met Asp 
        995                 1000                 1005             


His Glu  Ala Ser Phe Phe Gly  Ala Phe Leu Val Gly  
    1010                 1015                 1020 


<210>  257
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible peptide

<400>  257

Gly Gly Ser Gly Gly 
1               5   


<210>  258
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexibel linker with glycosylation motif

<400>  258

Gly Ser Gly Asn Gly Thr Ser Asn Gly Thr Ser Gly Ser Ser Gly Gly 
1               5                   10                  15      


<210>  259
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible peptide with glycosylation motif

<400>  259

Gly Ser Gly Asn Gly Thr Ser Asn Gly Thr Ser Gly Ser Ser Arg Thr 
1               5                   10                  15      


<210>  260
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  flexible peptide

<400>  260

Gly Gly Gly Gly Ser 
1               5   


