                         SEQUENCE LISTING

<110>  Electrophoretics Limited
 
<120>  Materials and Methods for Diagnosis and Treatment of Alzheimer's 
       Disease

<130>  CSF Microglia-PCT

<150>  GB1504432.4
<151>  2015-03-17

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Lys Ile Val Thr Val Lys Thr Gln Ala Tyr Gln Asp Gln Lys 
1               5                   10                  15      


Pro Gly Thr Ser Gly Leu Arg Lys Arg Val Lys Val Phe Gln Ser Ser 
            20                  25                  30          


Ala Asn Tyr Ala Glu Asn Phe Ile Gln Ser Ile Ile Ser Thr Val Glu 
        35                  40                  45              


Pro Ala Gln Arg Gln Glu Ala Thr Leu Val Val Gly Gly Asp Gly Arg 
    50                  55                  60                  


Phe Tyr Met Lys Glu Ala Ile Gln Leu Ile Ala Arg Ile Ala Ala Ala 
65                  70                  75                  80  


Asn Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu Ser Thr 
                85                  90                  95      


Pro Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly Gly Ile 
            100                 105                 110         


Ile Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp Phe Gly 
        115                 120                 125             


Ile Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala Ile Thr 
    130                 135                 140                 


Asp Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala Val Cys 
145                 150                 155                 160 


Pro Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln Phe Asp 
                165                 170                 175     


Leu Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp Ser Val 
            180                 185                 190         


Glu Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe Ser Ala Leu 
        195                 200                 205             


Lys Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile Asp Ala 
    210                 215                 220                 


Met His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys Glu Glu 
225                 230                 235                 240 


Leu Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu Glu Asp 
                245                 250                 255     


Phe Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala Asp Leu 
            260                 265                 270         


Val Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala Phe Asp 
        275                 280                 285             


Gly Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe Phe Val 
    290                 295                 300                 


Asn Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe Ser Ile 
305                 310                 315                 320 


Pro Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser Met Pro 
                325                 330                 335     


Thr Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys Ile Ala Leu 
            340                 345                 350         


Tyr Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met Asp Ala 
        355                 360                 365             


Ser Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly Ser Asp 
    370                 375                 380                 


His Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp Leu Ser 
385                 390                 395                 400 


Ile Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu Lys Asp His 
                405                 410                 415     


Trp Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr Glu Glu 
            420                 425                 430         


Val Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu Ala Leu 
        435                 440                 445             


Met Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn Asp Lys 
    450                 455                 460                 


Val Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp Pro Val 
465                 470                 475                 480 


Asp Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile Phe Thr Asp 
                485                 490                 495     


Gly Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser Ala Gly Ala 
            500                 505                 510         


Thr Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val Ala Lys Ile 
        515                 520                 525             


Asn Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile Ala Leu 
    530                 535                 540                 


Lys Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro Thr Val 
545                 550                 555                 560 


Ile Thr 
        


<210>  2
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Asp Lys Pro Asp Met Ala Glu Ile Glu Lys Phe Asp Lys Ser 
1               5                   10                  15      


Lys Leu Lys Lys Thr Glu Thr Gln Glu Lys Asn Pro Leu Pro Ser Lys 
            20                  25                  30          


Glu Thr Ile Glu Gln Glu Lys Gln Ala Gly Glu Ser 
        35                  40                  


<210>  3
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Asp Phe Glu Glu Trp Ile Ser Gly Thr Tyr Arg Lys Met Glu 
1               5                   10                  15      


Glu Gly Pro Leu Pro Leu Leu Thr Phe Ala Thr Ala Pro Tyr His Asp 
            20                  25                  30          


Gln Lys Pro Gly Thr Ser Gly Leu Arg Lys Lys Thr Tyr Tyr Phe Glu 
        35                  40                  45              


Glu Lys Pro Cys Tyr Leu Glu Asn Phe Ile Gln Ser Ile Phe Phe Ser 
    50                  55                  60                  


Ile Asp Leu Lys Asp Arg Gln Gly Ser Ser Leu Val Val Gly Gly Asp 
65                  70                  75                  80  


Gly Arg Tyr Phe Asn Lys Ser Ala Ile Glu Thr Ile Val Gln Met Ala 
                85                  90                  95      


Ala Ala Asn Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu 
            100                 105                 110         


Ser Thr Pro Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly 
        115                 120                 125             


Gly Ile Ile Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp 
    130                 135                 140                 


Phe Gly Ile Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala 
145                 150                 155                 160 


Ile Thr Asp Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala 
                165                 170                 175     


Val Cys Pro Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln 
            180                 185                 190         


Phe Asp Leu Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp 
        195                 200                 205             


Ser Val Glu Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe Ser 
    210                 215                 220                 


Ala Leu Lys Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile 
225                 230                 235                 240 


Asp Ala Met His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys 
                245                 250                 255     


Glu Glu Leu Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu 
            260                 265                 270         


Glu Asp Phe Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala 
        275                 280                 285             


Asp Leu Val Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala 
    290                 295                 300                 


Phe Asp Gly Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe 
305                 310                 315                 320 


Phe Val Asn Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe 
                325                 330                 335     


Ser Ile Pro Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser 
            340                 345                 350         


Met Pro Thr Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys Ile 
        355                 360                 365             


Ala Leu Tyr Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met 
    370                 375                 380                 


Asp Ala Ser Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly 
385                 390                 395                 400 


Ser Asp His Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp 
                405                 410                 415     


Leu Ser Ile Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu Lys 
            420                 425                 430         


Asp His Trp Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr 
        435                 440                 445             


Glu Glu Val Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu 
    450                 455                 460                 


Ala Leu Met Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn 
465                 470                 475                 480 


Asp Lys Val Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp 
                485                 490                 495     


Pro Val Asp Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile Phe 
            500                 505                 510         


Thr Asp Gly Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser Ala 
        515                 520                 525             


Gly Ala Thr Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val Ala 
    530                 535                 540                 


Lys Ile Asn Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile 
545                 550                 555                 560 


Ala Leu Lys Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro 
                565                 570                 575     


Thr Val Ile Thr 
            580 


<210>  4
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gln Leu Lys Pro Met Glu Ile Asn Pro Glu Met Leu Asn Lys Val 
1               5                   10                  15      


Leu Ser Arg Leu Gly Val Ala Gly Gln Trp Arg Phe Val Asp Val Leu 
            20                  25                  30          


Gly Leu Glu Glu Glu Ser Leu Gly Ser Val Pro Ala Pro Ala Cys Ala 
        35                  40                  45              


Leu Leu Leu Leu Phe Pro Leu Thr Ala Gln His Glu Asn Phe Arg Lys 
    50                  55                  60                  


Lys Gln Ile Glu Glu Leu Lys Gly Gln Glu Val Ser Pro Lys Val Tyr 
65                  70                  75                  80  


Phe Met Lys Gln Thr Ile Gly Asn Ser Cys Gly Thr Ile Gly Leu Ile 
                85                  90                  95      


His Ala Val Ala Asn Asn Gln Asp Lys Leu Gly Phe Glu Asp Gly Ser 
            100                 105                 110         


Val Leu Lys Gln Phe Leu Ser Glu Thr Glu Lys Met Ser Pro Glu Asp 
        115                 120                 125             


Arg Ala Lys Cys Phe Glu Lys Asn Glu Ala Ile Gln Ala Ala His Asp 
    130                 135                 140                 


Ala Val Ala Gln Glu Gly Gln Cys Arg Val Asp Asp Lys Val Asn Phe 
145                 150                 155                 160 


His Phe Ile Leu Phe Asn Asn Val Asp Gly His Leu Tyr Glu Leu Asp 
                165                 170                 175     


Gly Arg Met Pro Phe Pro Val Asn His Gly Ala Ser Ser Glu Asp Thr 
            180                 185                 190         


Leu Leu Lys Val Ile Phe Gly Met His Leu Phe Leu Met Thr Leu Pro 
        195                 200                 205             


Arg Ser Ala Glu Asn Ser Pro Ser Val Ser Lys Glu Lys Ser Ala Ser 
    210                 215                 220                 


Leu Pro Trp Leu Ser Ala Arg Gln Pro Asn Ala Leu Trp Glu Gly Leu 
225                 230                 235                 240 


Cys 
    


<210>  5
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Lys Arg Val Leu Val Leu Leu Leu Ala Val Ala Phe Gly His Ala 
1               5                   10                  15      


Leu Glu Arg Gly Arg Asp Tyr Glu Lys Asn Lys Val Cys Lys Glu Phe 
            20                  25                  30          


Ser His Leu Gly Lys Glu Asp Phe Thr Ser Leu Ser Leu Val Leu Tyr 
        35                  40                  45              


Ser Arg Lys Phe Pro Ser Gly Thr Phe Glu Gln Val Ser Gln Leu Val 
    50                  55                  60                  


Lys Glu Val Val Ser Leu Thr Glu Ala Cys Cys Ala Glu Gly Ala Asp 
65                  70                  75                  80  


Pro Asp Cys Tyr Asp Thr Arg Thr Ser Ala Leu Ser Ala Lys Ser Cys 
                85                  90                  95      


Glu Ser Asn Ser Pro Phe Pro Val His Pro Gly Thr Ala Glu Cys Cys 
            100                 105                 110         


Thr Lys Glu Gly Leu Glu Arg Lys Leu Cys Met Ala Ala Leu Lys His 
        115                 120                 125             


Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu Ile 
    130                 135                 140                 


Cys Glu Ala Phe Arg Lys Asp Pro Lys Glu Tyr Ala Asn Gln Phe Met 
145                 150                 155                 160 


Trp Glu Tyr Ser Thr Asn Tyr Gly Gln Ala Pro Leu Ser Leu Leu Val 
                165                 170                 175     


Ser Tyr Thr Lys Ser Tyr Leu Ser Met Val Gly Ser Cys Cys Thr Ser 
            180                 185                 190         


Ala Ser Pro Thr Val Cys Phe Leu Lys Glu Arg Leu Gln Leu Lys His 
        195                 200                 205             


Leu Ser Leu Leu Thr Thr Leu Ser Asn Arg Val Cys Ser Gln Tyr Ala 
    210                 215                 220                 


Ala Tyr Gly Glu Lys Lys Ser Arg Leu Ser Asn Leu Ile Lys Leu Ala 
225                 230                 235                 240 


Gln Lys Val Pro Thr Ala Asp Leu Glu Asp Val Leu Pro Leu Ala Glu 
                245                 250                 255     


Asp Ile Thr Asn Ile Leu Ser Lys Cys Cys Glu Ser Ala Ser Glu Asp 
            260                 265                 270         


Cys Met Ala Lys Glu Leu Pro Glu His Thr Val Lys Leu Cys Asp Asn 
        275                 280                 285             


Leu Ser Thr Lys Asn Ser Lys Phe Glu Asp Cys Cys Gln Glu Lys Thr 
    290                 295                 300                 


Ala Met Asp Val Phe Val Cys Thr Tyr Phe Met Pro Ala Ala Gln Leu 
305                 310                 315                 320 


Pro Glu Leu Pro Asp Val Glu Leu Pro Thr Asn Lys Asp Val Cys Asp 
                325                 330                 335     


Pro Gly Asn Thr Lys Val Met Asp Lys Ala Leu Tyr 
            340                 345             


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphoglucomutase 1 - peptide 1

<400>  6

Gln Phe Ser Ala Asn Asp Lys 
1               5           


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphoglucomutase 1 - peptide 2

<400>  7

Ile Asp Ala Met His Gly Val Val Gly Pro Tyr Val Lys 
1               5                   10              


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphoglucomutase 1 - peptide 3

<400>  8

Val Asp Leu Gly Val Leu Gly Lys 
1               5               


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphoglucomutase 1 - peptide 4

<400>  9

Leu Tyr Ile Asp Ser Tyr Glu Lys 
1               5               


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphoglucomutase 1 - peptide 5

<400>  10

Ser Met Pro Thr Ser Gly Ala Leu Asp Arg 
1               5                   10  


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphoglucomutase 1 - peptide 6

<400>  11

Tyr Asp Tyr Glu Glu Val Glu Ala Glu Gly Ala Asn Lys 
1               5                   10              


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphoglucomutase 1 - peptide 7

<400>  12

Ile Ala Leu Tyr Glu Thr Pro Thr Gly Trp Lys 
1               5                   10      


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Phosphoglucomutase 1 - peptide 8

<400>  13

Gln Ser Val Glu Asp Ile Leu Lys 
1               5               


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thymosine beta-4 - peptide 1

<400>  14

Asn Pro Leu Pro Ser Lys Glu Thr Ile Glu Gln Glu Lys 
1               5                   10              


<210>  15
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thymosine beta-4 - peptide 2

<400>  15

Thr Glu Thr Gln Glu Lys Asn Pro Leu Pro Ser Lys 
1               5                   10          


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thymosine beta-4 - peptide 3

<400>  16

Glu Thr Ile Glu Gln Glu Lys 
1               5           


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ubiquitin carboxyl-terminal hydrolase isoenzyme L1 - peptide 1

<400>  17

Gln Ile Glu Glu Leu Lys Gly Gln Glu Val Ser Pro Lys 
1               5                   10              


<210>  18
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vitamin D binding protein - peptide 1

<400>  18

His Gln Pro Gln Glu Phe Pro Thr Tyr Val Glu Pro Thr Asn Asp Glu 
1               5                   10                  15      


Ile Cys Glu Ala Phe Arg Lys 
            20              


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Apolipoprotein E - peptide 1

<400>  19

Ala Tyr Lys Ser Glu Leu Glu Glu Gln Leu Thr Pro Val Ala Glu Glu 
1               5                   10                  15      


Thr Arg 
        


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Secretogranin-1 - peptide 1

<400>  20

Gly Tyr Pro Gly Val Gln Ala Pro Glu Asp Leu Glu Trp Glu Arg 
1               5                   10                  15  


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Serine/threonine-protein phosphatase 2A 65 kDa reregulatory 
       subunit A alpha isoform - peptide 1

<400>  21

Ala Val Gly Pro Glu Ile Thr Lys 
1               5               


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cytoplasmic dynein 1 heavy chain 1- peptide 1

<400>  22

Leu Arg Asp Gln Leu Gly Thr Ala Lys 
1               5                   


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvB-like 1- peptide 1

<400>  23

Lys Thr Glu Ile Thr Asp Lys 
1               5           


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cDNA FLJ54806- peptide 1

<400>  24

Trp Glu Leu Asn Thr Tyr Leu Tyr Ala Pro Lys 
1               5                   10      


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha-1-acid glycoprotein 2- peptide 1

<400>  25

Ser Asp Val Met Tyr Thr Asp Trp Lys Lys 
1               5                   10  


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ras-related protein Rab-13- peptide 1

<400>  26

Phe Phe Glu Thr Ser Ala Lys 
1               5           


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Serum albumin - peptide 1

<400>  27

Asp Ala His Lys Ser Glu Val Ala His Arg 
1               5                   10  


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pigment epithelium-derived factor - peptide 1

<400>  28

Leu Lys Leu Ser Tyr Glu Gly Glu Val Thr Lys 
1               5                   10      


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amyloid A-4 protein - peptide 1

<400>  29

Glu Ala Leu Gln Gly Val Gly Asp Met Gly Arg 
1               5                   10      


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated apolipoprotein A-I - peptide 1

<400>  30

Leu Ala Glu Tyr His Ala Lys 
1               5           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fibrinogen alpha chain - peptide 1

<400>  31

Thr Val Ile Gly Pro Asp Gly His Lys 
1               5                   


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Haptoglobin - peptide 1

<400>  32

Asp Ile Ala Pro Thr Leu Thr Leu Tyr Val Gly Lys 
1               5                   10          


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha-1-antitrypsin - peptide 1

<400>  33

Ser Ala Ser Leu His Leu Pro Lys 
1               5               


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ig mu chain C region - peptide 1

<400>  34

Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys 
1               5                   10                  15  


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hemoglobin subunit delta - peptide 1

<400>  35

Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp Asn Leu Lys 
1               5                   10                  15      


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hemoglobin subunit delta - peptide 1

<400>  36

Ile Ser Val Ala Gln Gly Ala Ser Lys 
1               5                   


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Dynactin Subunit 1 - peptide 1

<400>  37

Ile Lys Asp Ala Leu Val Arg 
1               5           


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cofilin-1 - peptide 1

<400>  38

Met Ile Tyr Ala Ser Ser Lys 
1               5           


<210>  39
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210>  40
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gln Pro Thr Leu Leu Leu Ser Leu Leu Gly Ala Val Gly Leu Ala 
1               5                   10                  15      


Ala Val Asn Ser Met Pro Val Asp Asn Arg Asn His Asn Glu Gly Met 
            20                  25                  30          


Val Thr Arg Cys Ile Ile Glu Val Leu Ser Asn Ala Leu Ser Lys Ser 
        35                  40                  45              


Ser Ala Pro Pro Ile Thr Pro Glu Cys Arg Gln Val Leu Lys Thr Ser 
    50                  55                  60                  


Arg Lys Asp Val Lys Asp Lys Glu Thr Thr Glu Asn Glu Asn Thr Lys 
65                  70                  75                  80  


Phe Glu Val Arg Leu Leu Arg Asp Pro Ala Asp Ala Ser Glu Ala His 
                85                  90                  95      


Glu Ser Ser Ser Arg Gly Glu Ala Gly Ala Pro Gly Glu Glu Asp Ile 
            100                 105                 110         


Gln Gly Pro Thr Lys Ala Asp Thr Glu Lys Trp Ala Glu Gly Gly Gly 
        115                 120                 125             


His Ser Arg Glu Arg Ala Asp Glu Pro Gln Trp Ser Leu Tyr Pro Ser 
    130                 135                 140                 


Asp Ser Gln Val Ser Glu Glu Val Lys Thr Arg His Ser Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Glu Asp Glu Glu Glu Glu Glu Gly Glu Asn Tyr Gln Lys Gly 
                165                 170                 175     


Glu Arg Gly Glu Asp Ser Ser Glu Glu Lys His Leu Glu Glu Pro Gly 
            180                 185                 190         


Glu Thr Gln Asn Ala Phe Leu Asn Glu Arg Lys Gln Ala Ser Ala Ile 
        195                 200                 205             


Lys Lys Glu Glu Leu Val Ala Arg Ser Glu Thr His Ala Ala Gly His 
    210                 215                 220                 


Ser Gln Glu Lys Thr His Ser Arg Glu Lys Ser Ser Gln Glu Ser Gly 
225                 230                 235                 240 


Glu Glu Thr Gly Ser Gln Glu Asn His Pro Gln Glu Ser Lys Gly Gln 
                245                 250                 255     


Pro Arg Ser Gln Glu Glu Ser Glu Glu Gly Glu Glu Asp Ala Thr Ser 
            260                 265                 270         


Glu Val Asp Lys Arg Arg Thr Arg Pro Arg His His His Gly Arg Ser 
        275                 280                 285             


Arg Pro Asp Arg Ser Ser Gln Gly Gly Ser Leu Pro Ser Glu Glu Lys 
    290                 295                 300                 


Gly His Pro Gln Glu Glu Ser Glu Glu Ser Asn Val Ser Met Ala Ser 
305                 310                 315                 320 


Leu Gly Glu Lys Arg Asp His His Ser Thr His Tyr Arg Ala Ser Glu 
                325                 330                 335     


Glu Glu Pro Glu Tyr Gly Glu Glu Ile Lys Gly Tyr Pro Gly Val Gln 
            340                 345                 350         


Ala Pro Glu Asp Leu Glu Trp Glu Arg Tyr Arg Gly Arg Gly Ser Glu 
        355                 360                 365             


Glu Tyr Arg Ala Pro Arg Pro Gln Ser Glu Glu Ser Trp Asp Glu Glu 
    370                 375                 380                 


Asp Lys Arg Asn Tyr Pro Ser Leu Glu Leu Asp Lys Met Ala His Gly 
385                 390                 395                 400 


Tyr Gly Glu Glu Ser Glu Glu Glu Arg Gly Leu Glu Pro Gly Lys Gly 
                405                 410                 415     


Arg His His Arg Gly Arg Gly Gly Glu Pro Arg Ala Tyr Phe Met Ser 
            420                 425                 430         


Asp Thr Arg Glu Glu Lys Arg Phe Leu Gly Glu Gly His His Arg Val 
        435                 440                 445             


Gln Glu Asn Gln Met Asp Lys Ala Arg Arg His Pro Gln Gly Ala Trp 
    450                 455                 460                 


Lys Glu Leu Asp Arg Asn Tyr Leu Asn Tyr Gly Glu Glu Gly Ala Pro 
465                 470                 475                 480 


Gly Lys Trp Gln Gln Gln Gly Asp Leu Gln Asp Thr Lys Glu Asn Arg 
                485                 490                 495     


Glu Glu Ala Arg Phe Gln Asp Lys Gln Tyr Ser Ser His His Thr Ala 
            500                 505                 510         


Glu Lys Arg Lys Arg Leu Gly Glu Leu Phe Asn Pro Tyr Tyr Asp Pro 
        515                 520                 525             


Leu Gln Trp Lys Ser Ser His Phe Glu Arg Arg Asp Asn Met Asn Asp 
    530                 535                 540                 


Asn Phe Leu Glu Gly Glu Glu Glu Asn Glu Leu Thr Leu Asn Glu Lys 
545                 550                 555                 560 


Asn Phe Phe Pro Glu Tyr Asn Tyr Asp Trp Trp Glu Lys Lys Pro Phe 
                565                 570                 575     


Ser Glu Asp Val Asn Trp Gly Tyr Glu Lys Arg Asn Leu Ala Arg Val 
            580                 585                 590         


Pro Lys Leu Asp Leu Lys Arg Gln Tyr Asp Arg Val Ala Gln Leu Asp 
        595                 600                 605             


Gln Leu Leu His Tyr Arg Lys Lys Ser Ala Glu Phe Pro Asp Phe Tyr 
    610                 615                 620                 


Asp Ser Glu Glu Pro Val Ser Thr His Gln Glu Ala Glu Asn Glu Lys 
625                 630                 635                 640 


Asp Arg Ala Asp Gln Thr Val Leu Thr Glu Asp Glu Lys Lys Glu Leu 
                645                 650                 655     


Glu Asn Leu Ala Ala Met Asp Leu Glu Leu Gln Lys Ile Ala Glu Lys 
            660                 665                 670         


Phe Ser Gln Arg Gly 
        675         


<210>  41
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu 
1               5                   10                  15      


Ile Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile 
            20                  25                  30          


Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg 
        35                  40                  45              


Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu 
    50                  55                  60                  


Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val 
65                  70                  75                  80  


Gly Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu 
                85                  90                  95      


Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu 
            100                 105                 110         


Arg Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe 
        115                 120                 125             


Val Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg 
    130                 135                 140                 


Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser 
145                 150                 155                 160 


Ala Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp 
                165                 170                 175     


Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe 
            180                 185                 190         


Ala Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met 
        195                 200                 205             


Phe Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala 
    210                 215                 220                 


Val Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu 
225                 230                 235                 240 


Glu Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser 
                245                 250                 255     


Trp Arg Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys 
            260                 265                 270         


Ala Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln 
        275                 280                 285             


Asn Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His 
    290                 295                 300                 


Lys Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn 
305                 310                 315                 320 


Val Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp 
                325                 330                 335     


Ala Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu 
            340                 345                 350         


Ser Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu 
        355                 360                 365             


Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile 
    370                 375                 380                 


Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu 
385                 390                 395                 400 


Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys 
                405                 410                 415     


Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly 
            420                 425                 430         


Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met 
        435                 440                 445             


Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser 
    450                 455                 460                 


Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala 
465                 470                 475                 480 


Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu 
                485                 490                 495     


His Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys 
            500                 505                 510         


Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met 
        515                 520                 525             


Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu 
    530                 535                 540                 


Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val 
545                 550                 555                 560 


Lys Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys 
                565                 570                 575     


Tyr Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala 
            580                 585                 


<210>  42
<211>  4646
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Glu Pro Gly Gly Gly Gly Gly Glu Asp Gly Ser Ala Gly Leu 
1               5                   10                  15      


Glu Val Ser Ala Val Gln Asn Val Ala Asp Val Ser Val Leu Gln Lys 
            20                  25                  30          


His Leu Arg Lys Leu Val Pro Leu Leu Leu Glu Asp Gly Gly Glu Ala 
        35                  40                  45              


Pro Ala Ala Leu Glu Ala Ala Leu Glu Glu Lys Ser Ala Leu Glu Gln 
    50                  55                  60                  


Met Arg Lys Phe Leu Ser Asp Pro Gln Val His Thr Val Leu Val Glu 
65                  70                  75                  80  


Arg Ser Thr Leu Lys Glu Asp Val Gly Asp Glu Gly Glu Glu Glu Lys 
                85                  90                  95      


Glu Phe Ile Ser Tyr Asn Ile Asn Ile Asp Ile His Tyr Gly Val Lys 
            100                 105                 110         


Ser Asn Ser Leu Ala Phe Ile Lys Arg Thr Pro Val Ile Asp Ala Asp 
        115                 120                 125             


Lys Pro Val Ser Ser Gln Leu Arg Val Leu Thr Leu Ser Glu Asp Ser 
    130                 135                 140                 


Pro Tyr Glu Thr Leu His Ser Phe Ile Ser Asn Ala Val Ala Pro Phe 
145                 150                 155                 160 


Phe Lys Ser Tyr Ile Arg Glu Ser Gly Lys Ala Asp Arg Asp Gly Asp 
                165                 170                 175     


Lys Met Ala Pro Ser Val Glu Lys Lys Ile Ala Glu Leu Glu Met Gly 
            180                 185                 190         


Leu Leu His Leu Gln Gln Asn Ile Glu Ile Pro Glu Ile Ser Leu Pro 
        195                 200                 205             


Ile His Pro Met Ile Thr Asn Val Ala Lys Gln Cys Tyr Glu Arg Gly 
    210                 215                 220                 


Glu Lys Pro Lys Val Thr Asp Phe Gly Asp Lys Val Glu Asp Pro Thr 
225                 230                 235                 240 


Phe Leu Asn Gln Leu Gln Ser Gly Val Asn Arg Trp Ile Arg Glu Ile 
                245                 250                 255     


Gln Lys Val Thr Lys Leu Asp Arg Asp Pro Ala Ser Gly Thr Ala Leu 
            260                 265                 270         


Gln Glu Ile Ser Phe Trp Leu Asn Leu Glu Arg Ala Leu Tyr Arg Ile 
        275                 280                 285             


Gln Glu Lys Arg Glu Ser Pro Glu Val Leu Leu Thr Leu Asp Ile Leu 
    290                 295                 300                 


Lys His Gly Lys Arg Phe His Ala Thr Val Ser Phe Asp Thr Asp Thr 
305                 310                 315                 320 


Gly Leu Lys Gln Ala Leu Glu Thr Val Asn Asp Tyr Asn Pro Leu Met 
                325                 330                 335     


Lys Asp Phe Pro Leu Asn Asp Leu Leu Ser Ala Thr Glu Leu Asp Lys 
            340                 345                 350         


Ile Arg Gln Ala Leu Val Ala Ile Phe Thr His Leu Arg Lys Ile Arg 
        355                 360                 365             


Asn Thr Lys Tyr Pro Ile Gln Arg Ala Leu Arg Leu Val Glu Ala Ile 
    370                 375                 380                 


Ser Arg Asp Leu Ser Ser Gln Leu Leu Lys Val Leu Gly Thr Arg Lys 
385                 390                 395                 400 


Leu Met His Val Ala Tyr Glu Glu Phe Glu Lys Val Met Val Ala Cys 
                405                 410                 415     


Phe Glu Val Phe Gln Thr Trp Asp Asp Glu Tyr Glu Lys Leu Gln Val 
            420                 425                 430         


Leu Leu Arg Asp Ile Val Lys Arg Lys Arg Glu Glu Asn Leu Lys Met 
        435                 440                 445             


Val Trp Arg Ile Asn Pro Ala His Arg Lys Leu Gln Ala Arg Leu Asp 
    450                 455                 460                 


Gln Met Arg Lys Phe Arg Arg Gln His Glu Gln Leu Arg Ala Val Ile 
465                 470                 475                 480 


Val Arg Val Leu Arg Pro Gln Val Thr Ala Val Ala Gln Gln Asn Gln 
                485                 490                 495     


Gly Glu Val Pro Glu Pro Gln Asp Met Lys Val Ala Glu Val Leu Phe 
            500                 505                 510         


Asp Ala Ala Asp Ala Asn Ala Ile Glu Glu Val Asn Leu Ala Tyr Glu 
        515                 520                 525             


Asn Val Lys Glu Val Asp Gly Leu Asp Val Ser Lys Glu Gly Thr Glu 
    530                 535                 540                 


Ala Trp Glu Ala Ala Met Lys Arg Tyr Asp Glu Arg Ile Asp Arg Val 
545                 550                 555                 560 


Glu Thr Arg Ile Thr Ala Arg Leu Arg Asp Gln Leu Gly Thr Ala Lys 
                565                 570                 575     


Asn Ala Asn Glu Met Phe Arg Ile Phe Ser Arg Phe Asn Ala Leu Phe 
            580                 585                 590         


Val Arg Pro His Ile Arg Gly Ala Ile Arg Glu Tyr Gln Thr Gln Leu 
        595                 600                 605             


Ile Gln Arg Val Lys Asp Asp Ile Glu Ser Leu His Asp Lys Phe Lys 
    610                 615                 620                 


Val Gln Tyr Pro Gln Ser Gln Ala Cys Lys Met Ser His Val Arg Asp 
625                 630                 635                 640 


Leu Pro Pro Val Ser Gly Ser Ile Ile Trp Ala Lys Gln Ile Asp Arg 
                645                 650                 655     


Gln Leu Thr Ala Tyr Met Lys Arg Val Glu Asp Val Leu Gly Lys Gly 
            660                 665                 670         


Trp Glu Asn His Val Glu Gly Gln Lys Leu Lys Gln Asp Gly Asp Ser 
        675                 680                 685             


Phe Arg Met Lys Leu Asn Thr Gln Glu Ile Phe Asp Asp Trp Ala Arg 
    690                 695                 700                 


Lys Val Gln Gln Arg Asn Leu Gly Val Ser Gly Arg Ile Phe Thr Ile 
705                 710                 715                 720 


Glu Ser Thr Arg Val Arg Gly Arg Thr Gly Asn Val Leu Lys Leu Lys 
                725                 730                 735     


Val Asn Phe Leu Pro Glu Ile Ile Thr Leu Ser Lys Glu Val Arg Asn 
            740                 745                 750         


Leu Lys Trp Leu Gly Phe Arg Val Pro Leu Ala Ile Val Asn Lys Ala 
        755                 760                 765             


His Gln Ala Asn Gln Leu Tyr Pro Phe Ala Ile Ser Leu Ile Glu Ser 
    770                 775                 780                 


Val Arg Thr Tyr Glu Arg Thr Cys Glu Lys Val Glu Glu Arg Asn Thr 
785                 790                 795                 800 


Ile Ser Leu Leu Val Ala Gly Leu Lys Lys Glu Val Gln Ala Leu Ile 
                805                 810                 815     


Ala Glu Gly Ile Ala Leu Val Trp Glu Ser Tyr Lys Leu Asp Pro Tyr 
            820                 825                 830         


Val Gln Arg Leu Ala Glu Thr Val Phe Asn Phe Gln Glu Lys Val Asp 
        835                 840                 845             


Asp Leu Leu Ile Ile Glu Glu Lys Ile Asp Leu Glu Val Arg Ser Leu 
    850                 855                 860                 


Glu Thr Cys Met Tyr Asp His Lys Thr Phe Ser Glu Ile Leu Asn Arg 
865                 870                 875                 880 


Val Gln Lys Ala Val Asp Asp Leu Asn Leu His Ser Tyr Ser Asn Leu 
                885                 890                 895     


Pro Ile Trp Val Asn Lys Leu Asp Met Glu Ile Glu Arg Ile Leu Gly 
            900                 905                 910         


Val Arg Leu Gln Ala Gly Leu Arg Ala Trp Thr Gln Val Leu Leu Gly 
        915                 920                 925             


Gln Ala Glu Asp Lys Ala Glu Val Asp Met Asp Thr Asp Ala Pro Gln 
    930                 935                 940                 


Val Ser His Lys Pro Gly Gly Glu Pro Lys Ile Lys Asn Val Val His 
945                 950                 955                 960 


Glu Leu Arg Ile Thr Asn Gln Val Ile Tyr Leu Asn Pro Pro Ile Glu 
                965                 970                 975     


Glu Cys Arg Tyr Lys Leu Tyr Gln Glu Met Phe Ala Trp Lys Met Val 
            980                 985                 990         


Val Leu Ser Leu Pro Arg Ile Gln  Ser Gln Arg Tyr Gln  Val Gly Val 
        995                 1000                 1005             


His Tyr  Glu Leu Thr Glu Glu  Glu Lys Phe Tyr Arg  Asn Ala Leu 
    1010                 1015                 1020             


Thr Arg  Met Pro Asp Gly Pro  Val Ala Leu Glu Glu  Ser Tyr Ser 
    1025                 1030                 1035             


Ala Val  Met Gly Ile Val Ser  Glu Val Glu Gln Tyr  Val Lys Val 
    1040                 1045                 1050             


Trp Leu  Gln Tyr Gln Cys Leu  Trp Asp Met Gln Ala  Glu Asn Ile 
    1055                 1060                 1065             


Tyr Asn  Arg Leu Gly Glu Asp  Leu Asn Lys Trp Gln  Ala Leu Leu 
    1070                 1075                 1080             


Val Gln  Ile Arg Lys Ala Arg  Gly Thr Phe Asp Asn  Ala Glu Thr 
    1085                 1090                 1095             


Lys Lys  Glu Phe Gly Pro Val  Val Ile Asp Tyr Gly  Lys Val Gln 
    1100                 1105                 1110             


Ser Lys  Val Asn Leu Lys Tyr  Asp Ser Trp His Lys  Glu Val Leu 
    1115                 1120                 1125             


Ser Lys  Phe Gly Gln Met Leu  Gly Ser Asn Met Thr  Glu Phe His 
    1130                 1135                 1140             


Ser Gln  Ile Ser Lys Ser Arg  Gln Glu Leu Glu Gln  His Ser Val 
    1145                 1150                 1155             


Asp Thr  Ala Ser Thr Ser Asp  Ala Val Thr Phe Ile  Thr Tyr Val 
    1160                 1165                 1170             


Gln Ser  Leu Lys Arg Lys Ile  Lys Gln Phe Glu Lys  Gln Val Glu 
    1175                 1180                 1185             


Leu Tyr  Arg Asn Gly Gln Arg  Leu Leu Glu Lys Gln  Arg Phe Gln 
    1190                 1195                 1200             


Phe Pro  Pro Ser Trp Leu Tyr  Ile Asp Asn Ile Glu  Gly Glu Trp 
    1205                 1210                 1215             


Gly Ala  Phe Asn Asp Ile Met  Arg Arg Lys Asp Ser  Ala Ile Gln 
    1220                 1225                 1230             


Gln Gln  Val Ala Asn Leu Gln  Met Lys Ile Val Gln  Glu Asp Arg 
    1235                 1240                 1245             


Ala Val  Glu Ser Arg Thr Thr  Asp Leu Leu Thr Asp  Trp Glu Lys 
    1250                 1255                 1260             


Thr Lys  Pro Val Thr Gly Asn  Leu Arg Pro Glu Glu  Ala Leu Gln 
    1265                 1270                 1275             


Ala Leu  Thr Ile Tyr Glu Gly  Lys Phe Gly Arg Leu  Lys Asp Asp 
    1280                 1285                 1290             


Arg Glu  Lys Cys Ala Lys Ala  Lys Glu Ala Leu Glu  Leu Thr Asp 
    1295                 1300                 1305             


Thr Gly  Leu Leu Ser Gly Ser  Glu Glu Arg Val Gln  Val Ala Leu 
    1310                 1315                 1320             


Glu Glu  Leu Gln Asp Leu Lys  Gly Val Trp Ser Glu  Leu Ser Lys 
    1325                 1330                 1335             


Val Trp  Glu Gln Ile Asp Gln  Met Lys Glu Gln Pro  Trp Val Ser 
    1340                 1345                 1350             


Val Gln  Pro Arg Lys Leu Arg  Gln Asn Leu Asp Ala  Leu Leu Asn 
    1355                 1360                 1365             


Gln Leu  Lys Ser Phe Pro Ala  Arg Leu Arg Gln Tyr  Ala Ser Tyr 
    1370                 1375                 1380             


Glu Phe  Val Gln Arg Leu Leu  Lys Gly Tyr Met Lys  Ile Asn Met 
    1385                 1390                 1395             


Leu Val  Ile Glu Leu Lys Ser  Glu Ala Leu Lys Asp  Arg His Trp 
    1400                 1405                 1410             


Lys Gln  Leu Met Lys Arg Leu  His Val Asn Trp Val  Val Ser Glu 
    1415                 1420                 1425             


Leu Thr  Leu Gly Gln Ile Trp  Asp Val Asp Leu Gln  Lys Asn Glu 
    1430                 1435                 1440             


Ala Ile  Val Lys Asp Val Leu  Leu Val Ala Gln Gly  Glu Met Ala 
    1445                 1450                 1455             


Leu Glu  Glu Phe Leu Lys Gln  Ile Arg Glu Val Trp  Asn Thr Tyr 
    1460                 1465                 1470             


Glu Leu  Asp Leu Val Asn Tyr  Gln Asn Lys Cys Arg  Leu Ile Arg 
    1475                 1480                 1485             


Gly Trp  Asp Asp Leu Phe Asn  Lys Val Lys Glu His  Ile Asn Ser 
    1490                 1495                 1500             


Val Ser  Ala Met Lys Leu Ser  Pro Tyr Tyr Lys Val  Phe Glu Glu 
    1505                 1510                 1515             


Asp Ala  Leu Ser Trp Glu Asp  Lys Leu Asn Arg Ile  Met Ala Leu 
    1520                 1525                 1530             


Phe Asp  Val Trp Ile Asp Val  Gln Arg Arg Trp Val  Tyr Leu Glu 
    1535                 1540                 1545             


Gly Ile  Phe Thr Gly Ser Ala  Asp Ile Lys His Leu  Leu Pro Val 
    1550                 1555                 1560             


Glu Thr  Gln Arg Phe Gln Ser  Ile Ser Thr Glu Phe  Leu Ala Leu 
    1565                 1570                 1575             


Met Lys  Lys Val Ser Lys Ser  Pro Leu Val Met Asp  Val Leu Asn 
    1580                 1585                 1590             


Ile Gln  Gly Val Gln Arg Ser  Leu Glu Arg Leu Ala  Asp Leu Leu 
    1595                 1600                 1605             


Gly Lys  Ile Gln Lys Ala Leu  Gly Glu Tyr Leu Glu  Arg Glu Arg 
    1610                 1615                 1620             


Ser Ser  Phe Pro Arg Phe Tyr  Phe Val Gly Asp Glu  Asp Leu Leu 
    1625                 1630                 1635             


Glu Ile  Ile Gly Asn Ser Lys  Asn Val Ala Lys Leu  Gln Lys His 
    1640                 1645                 1650             


Phe Lys  Lys Met Phe Ala Gly  Val Ser Ser Ile Ile  Leu Asn Glu 
    1655                 1660                 1665             


Asp Asn  Ser Val Val Leu Gly  Ile Ser Ser Arg Glu  Gly Glu Glu 
    1670                 1675                 1680             


Val Met  Phe Lys Thr Pro Val  Ser Ile Thr Glu His  Pro Lys Ile 
    1685                 1690                 1695             


Asn Glu  Trp Leu Thr Leu Val  Glu Lys Glu Met Arg  Val Thr Leu 
    1700                 1705                 1710             


Ala Lys  Leu Leu Ala Glu Ser  Val Thr Glu Val Glu  Ile Phe Gly 
    1715                 1720                 1725             


Lys Ala  Thr Ser Ile Asp Pro  Asn Thr Tyr Ile Thr  Trp Ile Asp 
    1730                 1735                 1740             


Lys Tyr  Gln Ala Gln Leu Val  Val Leu Ser Ala Gln  Ile Ala Trp 
    1745                 1750                 1755             


Ser Glu  Asn Val Glu Thr Ala  Leu Ser Ser Met Gly  Gly Gly Gly 
    1760                 1765                 1770             


Asp Ala  Ala Pro Leu His Ser  Val Leu Ser Asn Val  Glu Val Thr 
    1775                 1780                 1785             


Leu Asn  Val Leu Ala Asp Ser  Val Leu Met Glu Gln  Pro Pro Leu 
    1790                 1795                 1800             


Arg Arg  Arg Lys Leu Glu His  Leu Ile Thr Glu Leu  Val His Gln 
    1805                 1810                 1815             


Arg Asp  Val Thr Arg Ser Leu  Ile Lys Ser Lys Ile  Asp Asn Ala 
    1820                 1825                 1830             


Lys Ser  Phe Glu Trp Leu Ser  Gln Met Arg Phe Tyr  Phe Asp Pro 
    1835                 1840                 1845             


Lys Gln  Thr Asp Val Leu Gln  Gln Leu Ser Ile Gln  Met Ala Asn 
    1850                 1855                 1860             


Ala Lys  Phe Asn Tyr Gly Phe  Glu Tyr Leu Gly Val  Gln Asp Lys 
    1865                 1870                 1875             


Leu Val  Gln Thr Pro Leu Thr  Asp Arg Cys Tyr Leu  Thr Met Thr 
    1880                 1885                 1890             


Gln Ala  Leu Glu Ala Arg Leu  Gly Gly Ser Pro Phe  Gly Pro Ala 
    1895                 1900                 1905             


Gly Thr  Gly Lys Thr Glu Ser  Val Lys Ala Leu Gly  His Gln Leu 
    1910                 1915                 1920             


Gly Arg  Phe Val Leu Val Phe  Asn Cys Asp Glu Thr  Phe Asp Phe 
    1925                 1930                 1935             


Gln Ala  Met Gly Arg Ile Phe  Val Gly Leu Cys Gln  Val Gly Ala 
    1940                 1945                 1950             


Trp Gly  Cys Phe Asp Glu Phe  Asn Arg Leu Glu Glu  Arg Met Leu 
    1955                 1960                 1965             


Ser Ala  Val Ser Gln Gln Val  Gln Cys Ile Gln Glu  Ala Leu Arg 
    1970                 1975                 1980             


Glu His  Ser Asn Pro Asn Tyr  Asp Lys Thr Ser Ala  Pro Ile Thr 
    1985                 1990                 1995             


Cys Glu  Leu Leu Asn Lys Gln  Val Lys Val Ser Pro  Asp Met Ala 
    2000                 2005                 2010             


Ile Phe  Ile Thr Met Asn Pro  Gly Tyr Ala Gly Arg  Ser Asn Leu 
    2015                 2020                 2025             


Pro Asp  Asn Leu Lys Lys Leu  Phe Arg Ser Leu Ala  Met Thr Lys 
    2030                 2035                 2040             


Pro Asp  Arg Gln Leu Ile Ala  Gln Val Met Leu Tyr  Ser Gln Gly 
    2045                 2050                 2055             


Phe Arg  Thr Ala Glu Val Leu  Ala Asn Lys Ile Val  Pro Phe Phe 
    2060                 2065                 2070             


Lys Leu  Cys Asp Glu Gln Leu  Ser Ser Gln Ser His  Tyr Asp Phe 
    2075                 2080                 2085             


Gly Leu  Arg Ala Leu Lys Ser  Val Leu Val Ser Ala  Gly Asn Val 
    2090                 2095                 2100             


Lys Arg  Glu Arg Ile Gln Lys  Ile Lys Arg Glu Lys  Glu Glu Arg 
    2105                 2110                 2115             


Gly Glu  Ala Val Asp Glu Gly  Glu Ile Ala Glu Asn  Leu Pro Glu 
    2120                 2125                 2130             


Gln Glu  Ile Leu Ile Gln Ser  Val Cys Glu Thr Met  Val Pro Lys 
    2135                 2140                 2145             


Leu Val  Ala Glu Asp Ile Pro  Leu Leu Phe Ser Leu  Leu Ser Asp 
    2150                 2155                 2160             


Val Phe  Pro Gly Val Gln Tyr  His Arg Gly Glu Met  Thr Ala Leu 
    2165                 2170                 2175             


Arg Glu  Glu Leu Lys Lys Val  Cys Gln Glu Met Tyr  Leu Thr Tyr 
    2180                 2185                 2190             


Gly Asp  Gly Glu Glu Val Gly  Gly Met Trp Val Glu  Lys Val Leu 
    2195                 2200                 2205             


Gln Leu  Tyr Gln Ile Thr Gln  Ile Asn His Gly Leu  Met Met Val 
    2210                 2215                 2220             


Gly Pro  Ser Gly Ser Gly Lys  Ser Met Ala Trp Arg  Val Leu Leu 
    2225                 2230                 2235             


Lys Ala  Leu Glu Arg Leu Glu  Gly Val Glu Gly Val  Ala His Ile 
    2240                 2245                 2250             


Ile Asp  Pro Lys Ala Ile Ser  Lys Asp His Leu Tyr  Gly Thr Leu 
    2255                 2260                 2265             


Asp Pro  Asn Thr Arg Glu Trp  Thr Asp Gly Leu Phe  Thr His Val 
    2270                 2275                 2280             


Leu Arg  Lys Ile Ile Asp Ser  Val Arg Gly Glu Leu  Gln Lys Arg 
    2285                 2290                 2295             


Gln Trp  Ile Val Phe Asp Gly  Asp Val Asp Pro Glu  Trp Val Glu 
    2300                 2305                 2310             


Asn Leu  Asn Ser Val Leu Asp  Asp Asn Lys Leu Leu  Thr Leu Pro 
    2315                 2320                 2325             


Asn Gly  Glu Arg Leu Ser Leu  Pro Pro Asn Val Arg  Ile Met Phe 
    2330                 2335                 2340             


Glu Val  Gln Asp Leu Lys Tyr  Ala Thr Leu Ala Thr  Val Ser Arg 
    2345                 2350                 2355             


Cys Gly  Met Val Trp Phe Ser  Glu Asp Val Leu Ser  Thr Asp Met 
    2360                 2365                 2370             


Ile Phe  Asn Asn Phe Leu Ala  Arg Leu Arg Ser Ile  Pro Leu Asp 
    2375                 2380                 2385             


Glu Gly  Glu Asp Glu Ala Gln  Arg Arg Arg Lys Gly  Lys Glu Asp 
    2390                 2395                 2400             


Glu Gly  Glu Glu Ala Ala Ser  Pro Met Leu Gln Ile  Gln Arg Asp 
    2405                 2410                 2415             


Ala Ala  Thr Ile Met Gln Pro  Tyr Phe Thr Ser Asn  Gly Leu Val 
    2420                 2425                 2430             


Thr Lys  Ala Leu Glu His Ala  Phe Gln Leu Glu His  Ile Met Asp 
    2435                 2440                 2445             


Leu Thr  Arg Leu Arg Cys Leu  Gly Ser Leu Phe Ser  Met Leu His 
    2450                 2455                 2460             


Gln Ala  Cys Arg Asn Val Ala  Gln Tyr Asn Ala Asn  His Pro Asp 
    2465                 2470                 2475             


Phe Pro  Met Gln Ile Glu Gln  Leu Glu Arg Tyr Ile  Gln Arg Tyr 
    2480                 2485                 2490             


Leu Val  Tyr Ala Ile Leu Trp  Ser Leu Ser Gly Asp  Ser Arg Leu 
    2495                 2500                 2505             


Lys Met  Arg Ala Glu Leu Gly  Glu Tyr Ile Arg Arg  Ile Thr Thr 
    2510                 2515                 2520             


Val Pro  Leu Pro Thr Ala Pro  Asn Ile Pro Ile Ile  Asp Tyr Glu 
    2525                 2530                 2535             


Val Ser  Ile Ser Gly Glu Trp  Ser Pro Trp Gln Ala  Lys Val Pro 
    2540                 2545                 2550             


Gln Ile  Glu Val Glu Thr His  Lys Val Ala Ala Pro  Asp Val Val 
    2555                 2560                 2565             


Val Pro  Thr Leu Asp Thr Val  Arg His Glu Ala Leu  Leu Tyr Thr 
    2570                 2575                 2580             


Trp Leu  Ala Glu His Lys Pro  Leu Val Leu Cys Gly  Pro Pro Gly 
    2585                 2590                 2595             


Ser Gly  Lys Thr Met Thr Leu  Phe Ser Ala Leu Arg  Ala Leu Pro 
    2600                 2605                 2610             


Asp Met  Glu Val Val Gly Leu  Asn Phe Ser Ser Ala  Thr Thr Pro 
    2615                 2620                 2625             


Glu Leu  Leu Leu Lys Thr Phe  Asp His Tyr Cys Glu  Tyr Arg Arg 
    2630                 2635                 2640             


Thr Pro  Asn Gly Val Val Leu  Ala Pro Val Gln Leu  Gly Lys Trp 
    2645                 2650                 2655             


Leu Val  Leu Phe Cys Asp Glu  Ile Asn Leu Pro Asp  Met Asp Lys 
    2660                 2665                 2670             


Tyr Gly  Thr Gln Arg Val Ile  Ser Phe Ile Arg Gln  Met Val Glu 
    2675                 2680                 2685             


His Gly  Gly Phe Tyr Arg Thr  Ser Asp Gln Thr Trp  Val Lys Leu 
    2690                 2695                 2700             


Glu Arg  Ile Gln Phe Val Gly  Ala Cys Asn Pro Pro  Thr Asp Pro 
    2705                 2710                 2715             


Gly Arg  Lys Pro Leu Ser His  Arg Phe Leu Arg His  Val Pro Val 
    2720                 2725                 2730             


Val Tyr  Val Asp Tyr Pro Gly  Pro Ala Ser Leu Thr  Gln Ile Tyr 
    2735                 2740                 2745             


Gly Thr  Phe Asn Arg Ala Met  Leu Arg Leu Ile Pro  Ser Leu Arg 
    2750                 2755                 2760             


Thr Tyr  Ala Glu Pro Leu Thr  Ala Ala Met Val Glu  Phe Tyr Thr 
    2765                 2770                 2775             


Met Ser  Gln Glu Arg Phe Thr  Gln Asp Thr Gln Pro  His Tyr Ile 
    2780                 2785                 2790             


Tyr Ser  Pro Arg Glu Met Thr  Arg Trp Val Arg Gly  Ile Phe Glu 
    2795                 2800                 2805             


Ala Leu  Arg Pro Leu Glu Thr  Leu Pro Val Glu Gly  Leu Ile Arg 
    2810                 2815                 2820             


Ile Trp  Ala His Glu Ala Leu  Arg Leu Phe Gln Asp  Arg Leu Val 
    2825                 2830                 2835             


Glu Asp  Glu Glu Arg Arg Trp  Thr Asp Glu Asn Ile  Asp Thr Val 
    2840                 2845                 2850             


Ala Leu  Lys His Phe Pro Asn  Ile Asp Arg Glu Lys  Ala Met Ser 
    2855                 2860                 2865             


Arg Pro  Ile Leu Tyr Ser Asn  Trp Leu Ser Lys Asp  Tyr Ile Pro 
    2870                 2875                 2880             


Val Asp  Gln Glu Glu Leu Arg  Asp Tyr Val Lys Ala  Arg Leu Lys 
    2885                 2890                 2895             


Val Phe  Tyr Glu Glu Glu Leu  Asp Val Pro Leu Val  Leu Phe Asn 
    2900                 2905                 2910             


Glu Val  Leu Asp His Val Leu  Arg Ile Asp Arg Ile  Phe Arg Gln 
    2915                 2920                 2925             


Pro Gln  Gly His Leu Leu Leu  Ile Gly Val Ser Gly  Ala Gly Lys 
    2930                 2935                 2940             


Thr Thr  Leu Ser Arg Phe Val  Ala Trp Met Asn Gly  Leu Ser Val 
    2945                 2950                 2955             


Tyr Gln  Ile Lys Val His Arg  Lys Tyr Thr Gly Glu  Asp Phe Asp 
    2960                 2965                 2970             


Glu Asp  Leu Arg Thr Val Leu  Arg Arg Ser Gly Cys  Lys Asn Glu 
    2975                 2980                 2985             


Lys Ile  Ala Phe Ile Met Asp  Glu Ser Asn Val Leu  Asp Ser Gly 
    2990                 2995                 3000             


Phe Leu  Glu Arg Met Asn Thr  Leu Leu Ala Asn Gly  Glu Val Pro 
    3005                 3010                 3015             


Gly Leu  Phe Glu Gly Asp Glu  Tyr Ala Thr Leu Met  Thr Gln Cys 
    3020                 3025                 3030             


Lys Glu  Gly Ala Gln Lys Glu  Gly Leu Met Leu Asp  Ser His Glu 
    3035                 3040                 3045             


Glu Leu  Tyr Lys Trp Phe Thr  Ser Gln Val Ile Arg  Asn Leu His 
    3050                 3055                 3060             


Val Val  Phe Thr Met Asn Pro  Ser Ser Glu Gly Leu  Lys Asp Arg 
    3065                 3070                 3075             


Ala Ala  Thr Ser Pro Ala Leu  Phe Asn Arg Cys Val  Leu Asn Trp 
    3080                 3085                 3090             


Phe Gly  Asp Trp Ser Thr Glu  Ala Leu Tyr Gln Val  Gly Lys Glu 
    3095                 3100                 3105             


Phe Thr  Ser Lys Met Asp Leu  Glu Lys Pro Asn Tyr  Ile Val Pro 
    3110                 3115                 3120             


Asp Tyr  Met Pro Val Val Tyr  Asp Lys Leu Pro Gln  Pro Pro Ser 
    3125                 3130                 3135             


His Arg  Glu Ala Ile Val Asn  Ser Cys Val Phe Val  His Gln Thr 
    3140                 3145                 3150             


Leu His  Gln Ala Asn Ala Arg  Leu Ala Lys Arg Gly  Gly Arg Thr 
    3155                 3160                 3165             


Met Ala  Ile Thr Pro Arg His  Tyr Leu Asp Phe Ile  Asn His Tyr 
    3170                 3175                 3180             


Ala Asn  Leu Phe His Glu Lys  Arg Ser Glu Leu Glu  Glu Gln Gln 
    3185                 3190                 3195             


Met His  Leu Asn Val Gly Leu  Arg Lys Ile Lys Glu  Thr Val Asp 
    3200                 3205                 3210             


Gln Val  Glu Glu Leu Arg Arg  Asp Leu Arg Ile Lys  Ser Gln Glu 
    3215                 3220                 3225             


Leu Glu  Val Lys Asn Ala Ala  Ala Asn Asp Lys Leu  Lys Lys Met 
    3230                 3235                 3240             


Val Lys  Asp Gln Gln Glu Ala  Glu Lys Lys Lys Val  Met Ser Gln 
    3245                 3250                 3255             


Glu Ile  Gln Glu Gln Leu His  Lys Gln Gln Glu Val  Ile Ala Asp 
    3260                 3265                 3270             


Lys Gln  Met Ser Val Lys Glu  Asp Leu Asp Lys Val  Glu Pro Ala 
    3275                 3280                 3285             


Val Ile  Glu Ala Gln Asn Ala  Val Lys Ser Ile Lys  Lys Gln His 
    3290                 3295                 3300             


Leu Val  Glu Val Arg Ser Met  Ala Asn Pro Pro Ala  Ala Val Lys 
    3305                 3310                 3315             


Leu Ala  Leu Glu Ser Ile Cys  Leu Leu Leu Gly Glu  Ser Thr Thr 
    3320                 3325                 3330             


Asp Trp  Lys Gln Ile Arg Ser  Ile Ile Met Arg Glu  Asn Phe Ile 
    3335                 3340                 3345             


Pro Thr  Ile Val Asn Phe Ser  Ala Glu Glu Ile Ser  Asp Ala Ile 
    3350                 3355                 3360             


Arg Glu  Lys Met Lys Lys Asn  Tyr Met Ser Asn Pro  Ser Tyr Asn 
    3365                 3370                 3375             


Tyr Glu  Ile Val Asn Arg Ala  Ser Leu Ala Cys Gly  Pro Met Val 
    3380                 3385                 3390             


Lys Trp  Ala Ile Ala Gln Leu  Asn Tyr Ala Asp Met  Leu Lys Arg 
    3395                 3400                 3405             


Val Glu  Pro Leu Arg Asn Glu  Leu Gln Lys Leu Glu  Asp Asp Ala 
    3410                 3415                 3420             


Lys Asp  Asn Gln Gln Lys Ala  Asn Glu Val Glu Gln  Met Ile Arg 
    3425                 3430                 3435             


Asp Leu  Glu Ala Ser Ile Ala  Arg Tyr Lys Glu Glu  Tyr Ala Val 
    3440                 3445                 3450             


Leu Ile  Ser Glu Ala Gln Ala  Ile Lys Ala Asp Leu  Ala Ala Val 
    3455                 3460                 3465             


Glu Ala  Lys Val Asn Arg Ser  Thr Ala Leu Leu Lys  Ser Leu Ser 
    3470                 3475                 3480             


Ala Glu  Arg Glu Arg Trp Glu  Lys Thr Ser Glu Thr  Phe Lys Asn 
    3485                 3490                 3495             


Gln Met  Ser Thr Ile Ala Gly  Asp Cys Leu Leu Ser  Ala Ala Phe 
    3500                 3505                 3510             


Ile Ala  Tyr Ala Gly Tyr Phe  Asp Gln Gln Met Arg  Gln Asn Leu 
    3515                 3520                 3525             


Phe Thr  Thr Trp Ser His His  Leu Gln Gln Ala Asn  Ile Gln Phe 
    3530                 3535                 3540             


Arg Thr  Asp Ile Ala Arg Thr  Glu Tyr Leu Ser Asn  Ala Asp Glu 
    3545                 3550                 3555             


Arg Leu  Arg Trp Gln Ala Ser  Ser Leu Pro Ala Asp  Asp Leu Cys 
    3560                 3565                 3570             


Thr Glu  Asn Ala Ile Met Leu  Lys Arg Phe Asn Arg  Tyr Pro Leu 
    3575                 3580                 3585             


Ile Ile  Asp Pro Ser Gly Gln  Ala Thr Glu Phe Ile  Met Asn Glu 
    3590                 3595                 3600             


Tyr Lys  Asp Arg Lys Ile Thr  Arg Thr Ser Phe Leu  Asp Asp Ala 
    3605                 3610                 3615             


Phe Arg  Lys Asn Leu Glu Ser  Ala Leu Arg Phe Gly  Asn Pro Leu 
    3620                 3625                 3630             


Leu Val  Gln Asp Val Glu Ser  Tyr Asp Pro Val Leu  Asn Pro Val 
    3635                 3640                 3645             


Leu Asn  Arg Glu Val Arg Arg  Thr Gly Gly Arg Val  Leu Ile Thr 
    3650                 3655                 3660             


Leu Gly  Asp Gln Asp Ile Asp  Leu Ser Pro Ser Phe  Val Ile Phe 
    3665                 3670                 3675             


Leu Ser  Thr Arg Asp Pro Thr  Val Glu Phe Pro Pro  Asp Leu Cys 
    3680                 3685                 3690             


Ser Arg  Val Thr Phe Val Asn  Phe Thr Val Thr Arg  Ser Ser Leu 
    3695                 3700                 3705             


Gln Ser  Gln Cys Leu Asn Glu  Val Leu Lys Ala Glu  Arg Pro Asp 
    3710                 3715                 3720             


Val Asp  Glu Lys Arg Ser Asp  Leu Leu Lys Leu Gln  Gly Glu Phe 
    3725                 3730                 3735             


Gln Leu  Arg Leu Arg Gln Leu  Glu Lys Ser Leu Leu  Gln Ala Leu 
    3740                 3745                 3750             


Asn Glu  Val Lys Gly Arg Ile  Leu Asp Asp Asp Thr  Ile Ile Thr 
    3755                 3760                 3765             


Thr Leu  Glu Asn Leu Lys Arg  Glu Ala Ala Glu Val  Thr Arg Lys 
    3770                 3775                 3780             


Val Glu  Glu Thr Asp Ile Val  Met Gln Glu Val Glu  Thr Val Ser 
    3785                 3790                 3795             


Gln Gln  Tyr Leu Pro Leu Ser  Thr Ala Cys Ser Ser  Ile Tyr Phe 
    3800                 3805                 3810             


Thr Met  Glu Ser Leu Lys Gln  Ile His Phe Leu Tyr  Gln Tyr Ser 
    3815                 3820                 3825             


Leu Gln  Phe Phe Leu Asp Ile  Tyr His Asn Val Leu  Tyr Glu Asn 
    3830                 3835                 3840             


Pro Asn  Leu Lys Gly Val Thr  Asp His Thr Gln Arg  Leu Ser Ile 
    3845                 3850                 3855             


Ile Thr  Lys Asp Leu Phe Gln  Val Ala Phe Asn Arg  Val Ala Arg 
    3860                 3865                 3870             


Gly Met  Leu His Gln Asp His  Ile Thr Phe Ala Met  Leu Leu Ala 
    3875                 3880                 3885             


Arg Ile  Lys Leu Lys Gly Thr  Val Gly Glu Pro Thr  Tyr Asp Ala 
    3890                 3895                 3900             


Glu Phe  Gln His Phe Leu Arg  Gly Asn Glu Ile Val  Leu Ser Ala 
    3905                 3910                 3915             


Gly Ser  Thr Pro Arg Ile Gln  Gly Leu Thr Val Glu  Gln Ala Glu 
    3920                 3925                 3930             


Ala Val  Val Arg Leu Ser Cys  Leu Pro Ala Phe Lys  Asp Leu Ile 
    3935                 3940                 3945             


Ala Lys  Val Gln Ala Asp Glu  Gln Phe Gly Ile Trp  Leu Asp Ser 
    3950                 3955                 3960             


Ser Ser  Pro Glu Gln Thr Val  Pro Tyr Leu Trp Ser  Glu Glu Thr 
    3965                 3970                 3975             


Pro Ala  Thr Pro Ile Gly Gln  Ala Ile His Arg Leu  Leu Leu Ile 
    3980                 3985                 3990             


Gln Ala  Phe Arg Pro Asp Arg  Leu Leu Ala Met Ala  His Met Phe 
    3995                 4000                 4005             


Val Ser  Thr Asn Leu Gly Glu  Ser Phe Met Ser Ile  Met Glu Gln 
    4010                 4015                 4020             


Pro Leu  Asp Leu Thr His Ile  Val Gly Thr Glu Val  Lys Pro Asn 
    4025                 4030                 4035             


Thr Pro  Val Leu Met Cys Ser  Val Pro Gly Tyr Asp  Ala Ser Gly 
    4040                 4045                 4050             


His Val  Glu Asp Leu Ala Ala  Glu Gln Asn Thr Gln  Ile Thr Ser 
    4055                 4060                 4065             


Ile Ala  Ile Gly Ser Ala Glu  Gly Phe Asn Gln Ala  Asp Lys Ala 
    4070                 4075                 4080             


Ile Asn  Thr Ala Val Lys Ser  Gly Arg Trp Val Met  Leu Lys Asn 
    4085                 4090                 4095             


Val His  Leu Ala Pro Gly Trp  Leu Met Gln Leu Glu  Lys Lys Leu 
    4100                 4105                 4110             


His Ser  Leu Gln Pro His Ala  Cys Phe Arg Leu Phe  Leu Thr Met 
    4115                 4120                 4125             


Glu Ile  Asn Pro Lys Val Pro  Val Asn Leu Leu Arg  Ala Gly Arg 
    4130                 4135                 4140             


Ile Phe  Val Phe Glu Pro Pro  Pro Gly Val Lys Ala  Asn Met Leu 
    4145                 4150                 4155             


Arg Thr  Phe Ser Ser Ile Pro  Val Ser Arg Ile Cys  Lys Ser Pro 
    4160                 4165                 4170             


Asn Glu  Arg Ala Arg Leu Tyr  Phe Leu Leu Ala Trp  Phe His Ala 
    4175                 4180                 4185             


Ile Ile  Gln Glu Arg Leu Arg  Tyr Ala Pro Leu Gly  Trp Ser Lys 
    4190                 4195                 4200             


Lys Tyr  Glu Phe Gly Glu Ser  Asp Leu Arg Ser Ala  Cys Asp Thr 
    4205                 4210                 4215             


Val Asp  Thr Trp Leu Asp Asp  Thr Ala Lys Gly Arg  Gln Asn Ile 
    4220                 4225                 4230             


Ser Pro  Asp Lys Ile Pro Trp  Ser Ala Leu Lys Thr  Leu Met Ala 
    4235                 4240                 4245             


Gln Ser  Ile Tyr Gly Gly Arg  Val Asp Asn Glu Phe  Asp Gln Arg 
    4250                 4255                 4260             


Leu Leu  Asn Thr Phe Leu Glu  Arg Leu Phe Thr Thr  Arg Ser Phe 
    4265                 4270                 4275             


Asp Ser  Glu Phe Lys Leu Ala  Cys Lys Val Asp Gly  His Lys Asp 
    4280                 4285                 4290             


Ile Gln  Met Pro Asp Gly Ile  Arg Arg Glu Glu Phe  Val Gln Trp 
    4295                 4300                 4305             


Val Glu  Leu Leu Pro Asp Thr  Gln Thr Pro Ser Trp  Leu Gly Leu 
    4310                 4315                 4320             


Pro Asn  Asn Ala Glu Arg Val  Leu Leu Thr Thr Gln  Gly Val Asp 
    4325                 4330                 4335             


Met Ile  Ser Lys Met Leu Lys  Met Gln Met Leu Glu  Asp Glu Asp 
    4340                 4345                 4350             


Asp Leu  Ala Tyr Ala Glu Thr  Glu Lys Lys Thr Arg  Thr Asp Ser 
    4355                 4360                 4365             


Thr Ser  Asp Gly Arg Pro Ala  Trp Met Arg Thr Leu  His Thr Thr 
    4370                 4375                 4380             


Ala Ser  Asn Trp Leu His Leu  Ile Pro Gln Thr Leu  Ser His Leu 
    4385                 4390                 4395             


Lys Arg  Thr Val Glu Asn Ile  Lys Asp Pro Leu Phe  Arg Phe Phe 
    4400                 4405                 4410             


Glu Arg  Glu Val Lys Met Gly  Ala Lys Leu Leu Gln  Asp Val Arg 
    4415                 4420                 4425             


Gln Asp  Leu Ala Asp Val Val  Gln Val Cys Glu Gly  Lys Lys Lys 
    4430                 4435                 4440             


Gln Thr  Asn Tyr Leu Arg Thr  Leu Ile Asn Glu Leu  Val Lys Gly 
    4445                 4450                 4455             


Ile Leu  Pro Arg Ser Trp Ser  His Tyr Thr Val Pro  Ala Gly Met 
    4460                 4465                 4470             


Thr Val  Ile Gln Trp Val Ser  Asp Phe Ser Glu Arg  Ile Lys Gln 
    4475                 4480                 4485             


Leu Gln  Asn Ile Ser Leu Ala  Ala Ala Ser Gly Gly  Ala Lys Glu 
    4490                 4495                 4500             


Leu Lys  Asn Ile His Val Cys  Leu Gly Gly Leu Phe  Val Pro Glu 
    4505                 4510                 4515             


Ala Tyr  Ile Thr Ala Thr Arg  Gln Tyr Val Ala Gln  Ala Asn Ser 
    4520                 4525                 4530             


Trp Ser  Leu Glu Glu Leu Cys  Leu Glu Val Asn Val  Thr Thr Ser 
    4535                 4540                 4545             


Gln Gly  Ala Thr Leu Asp Ala  Cys Ser Phe Gly Val  Thr Gly Leu 
    4550                 4555                 4560             


Lys Leu  Gln Gly Ala Thr Cys  Asn Asn Asn Lys Leu  Ser Leu Ser 
    4565                 4570                 4575             


Asn Ala  Ile Ser Thr Ala Leu  Pro Leu Thr Gln Leu  Arg Trp Val 
    4580                 4585                 4590             


Lys Gln  Thr Asn Thr Glu Lys  Lys Ala Ser Val Val  Thr Leu Pro 
    4595                 4600                 4605             


Val Tyr  Leu Asn Phe Thr Arg  Ala Asp Leu Ile Phe  Thr Val Asp 
    4610                 4615                 4620             


Phe Glu  Ile Ala Thr Lys Glu  Asp Pro Arg Ser Phe  Tyr Glu Arg 
    4625                 4630                 4635             


Gly Val  Ala Val Leu Cys Thr  Glu 
    4640                 4645     


<210>  43
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Lys Ile Glu Glu Val Lys Ser Thr Thr Lys Thr Gln Arg Ile Ala 
1               5                   10                  15      


Ser His Ser His Val Lys Gly Leu Gly Leu Asp Glu Ser Gly Leu Ala 
            20                  25                  30          


Lys Gln Ala Ala Ser Gly Leu Val Gly Gln Glu Asn Ala Arg Glu Ala 
        35                  40                  45              


Cys Gly Val Ile Val Glu Leu Ile Lys Ser Lys Lys Met Ala Gly Arg 
    50                  55                  60                  


Ala Val Leu Leu Ala Gly Pro Pro Gly Thr Gly Lys Thr Ala Leu Ala 
65                  70                  75                  80  


Leu Ala Ile Ala Gln Glu Leu Gly Ser Lys Val Pro Phe Cys Pro Met 
                85                  90                  95      


Val Gly Ser Glu Val Tyr Ser Thr Glu Ile Lys Lys Thr Glu Val Leu 
            100                 105                 110         


Met Glu Asn Phe Arg Arg Ala Ile Gly Leu Arg Ile Lys Glu Thr Lys 
        115                 120                 125             


Glu Val Tyr Glu Gly Glu Val Thr Glu Leu Thr Pro Cys Glu Thr Glu 
    130                 135                 140                 


Asn Pro Met Gly Gly Tyr Gly Lys Thr Ile Ser His Val Ile Ile Gly 
145                 150                 155                 160 


Leu Lys Thr Ala Lys Gly Thr Lys Gln Leu Lys Leu Asp Pro Ser Ile 
                165                 170                 175     


Phe Glu Ser Leu Gln Lys Glu Arg Val Glu Ala Gly Asp Val Ile Tyr 
            180                 185                 190         


Ile Glu Ala Asn Ser Gly Ala Val Lys Arg Gln Gly Arg Cys Asp Thr 
        195                 200                 205             


Tyr Ala Thr Glu Phe Asp Leu Glu Ala Glu Glu Tyr Val Pro Leu Pro 
    210                 215                 220                 


Lys Gly Asp Val His Lys Lys Lys Glu Ile Ile Gln Asp Val Thr Leu 
225                 230                 235                 240 


His Asp Leu Asp Val Ala Asn Ala Arg Pro Gln Gly Gly Gln Asp Ile 
                245                 250                 255     


Leu Ser Met Met Gly Gln Leu Met Lys Pro Lys Lys Thr Glu Ile Thr 
            260                 265                 270         


Asp Lys Leu Arg Gly Glu Ile Asn Lys Val Val Asn Lys Tyr Ile Asp 
        275                 280                 285             


Gln Gly Ile Ala Glu Leu Val Pro Gly Val Leu Phe Val Asp Glu Val 
    290                 295                 300                 


His Met Leu Asp Ile Glu Cys Phe Thr Tyr Leu His Arg Ala Leu Glu 
305                 310                 315                 320 


Ser Ser Ile Ala Pro Ile Val Ile Phe Ala Ser Asn Arg Gly Asn Cys 
                325                 330                 335     


Val Ile Arg Gly Thr Glu Asp Ile Thr Ser Pro His Gly Ile Pro Leu 
            340                 345                 350         


Asp Leu Leu Asp Arg Val Met Ile Ile Arg Thr Met Leu Tyr Thr Pro 
        355                 360                 365             


Gln Glu Met Lys Gln Ile Ile Lys Ile Arg Ala Gln Thr Glu Gly Ile 
    370                 375                 380                 


Asn Ile Ser Glu Glu Ala Leu Asn His Leu Gly Glu Ile Gly Thr Lys 
385                 390                 395                 400 


Thr Thr Leu Arg Tyr Ser Val Gln Leu Leu Thr Pro Ala Asn Leu Leu 
                405                 410                 415     


Ala Lys Ile Asn Gly Lys Asp Ser Ile Glu Lys Glu His Val Glu Glu 
            420                 425                 430         


Ile Ser Glu Leu Phe Tyr Asp Ala Lys Ser Ser Ala Lys Ile Leu Ala 
        435                 440                 445             


Asp Gln Gln Asp Lys Tyr Met Lys 
    450                 455     


<210>  44
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Val Gln Lys Glu Ser Gln Ala Thr Leu Glu Glu Arg Glu Ser Glu 
1               5                   10                  15      


Leu Ser Ser Asn Pro Ala Ala Ser Ala Gly Ala Ser Leu Glu Pro Pro 
            20                  25                  30          


Ala Ala Pro Ala Pro Gly Glu Asp Asn Pro Ala Gly Ala Gly Gly Ala 
        35                  40                  45              


Ala Val Ala Gly Ala Ala Gly Gly Ala Arg Arg Phe Leu Cys Gly Val 
    50                  55                  60                  


Val Glu Gly Phe Tyr Gly Arg Pro Trp Val Met Glu Gln Arg Lys Glu 
65                  70                  75                  80  


Leu Phe Arg Arg Leu Gln Lys Trp Glu Leu Asn Thr Tyr Leu Tyr Ala 
                85                  90                  95      


Pro Lys Asp Asp Tyr Lys His Arg Met Phe Trp Arg Glu Met Tyr Ser 
            100                 105                 110         


Val Glu Glu Ala Gly Ser Phe Leu Phe Phe Tyr Leu Val Thr Ile Gln 
        115                 120                 125             


Leu Ala Glu Ile Glu Arg Val Leu Cys Ala Ser Lys Val Met Thr Ile 
    130                 135                 140                 


Cys Val Ile Ser Trp Ala Cys 
145                 150     


<210>  45
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Leu Ser Trp Val Leu Thr Val Leu Ser Leu Leu Pro Leu Leu 
1               5                   10                  15      


Glu Ala Gln Ile Pro Leu Cys Ala Asn Leu Val Pro Val Pro Ile Thr 
            20                  25                  30          


Asn Ala Thr Leu Asp Arg Ile Thr Gly Lys Trp Phe Tyr Ile Ala Ser 
        35                  40                  45              


Ala Phe Arg Asn Glu Glu Tyr Asn Lys Ser Val Gln Glu Ile Gln Ala 
    50                  55                  60                  


Thr Phe Phe Tyr Phe Thr Pro Asn Lys Thr Glu Asp Thr Ile Phe Leu 
65                  70                  75                  80  


Arg Glu Tyr Gln Thr Arg Gln Asn Gln Cys Phe Tyr Asn Ser Ser Tyr 
                85                  90                  95      


Leu Asn Val Gln Arg Glu Asn Gly Thr Val Ser Arg Tyr Glu Gly Gly 
            100                 105                 110         


Arg Glu His Val Ala His Leu Leu Phe Leu Arg Asp Thr Lys Thr Leu 
        115                 120                 125             


Met Phe Gly Ser Tyr Leu Asp Asp Glu Lys Asn Trp Gly Leu Ser Phe 
    130                 135                 140                 


Tyr Ala Asp Lys Pro Glu Thr Thr Lys Glu Gln Leu Gly Glu Phe Tyr 
145                 150                 155                 160 


Glu Ala Leu Asp Cys Leu Cys Ile Pro Arg Ser Asp Val Met Tyr Thr 
                165                 170                 175     


Asp Trp Lys Lys Asp Lys Cys Glu Pro Leu Glu Lys Gln His Glu Lys 
            180                 185                 190         


Glu Arg Lys Gln Glu Glu Gly Glu Ser 
        195                 200     


<210>  46
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Lys Ala Tyr Asp His Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Cys Leu Ile Ile Arg Phe Ala Glu Asp Asn 
            20                  25                  30          


Phe Asn Asn Thr Tyr Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Val Asp Ile Glu Gly Lys Lys Ile Lys Leu Gln Val Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Lys Thr Ile Thr Thr Ala Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Met Gly Ile Ile Leu Val Tyr Asp Ile Thr Asp Glu Lys Ser Phe 
                85                  90                  95      


Glu Asn Ile Gln Asn Trp Met Lys Ser Ile Lys Glu Asn Ala Ser Ala 
            100                 105                 110         


Gly Val Glu Arg Leu Leu Leu Gly Asn Lys Cys Asp Met Glu Ala Lys 
        115                 120                 125             


Arg Lys Val Gln Lys Glu Gln Ala Asp Lys Leu Ala Arg Glu His Gly 
    130                 135                 140                 


Ile Arg Phe Phe Glu Thr Ser Ala Lys Ser Ser Met Asn Val Asp Glu 
145                 150                 155                 160 


Ala Phe Ser Ser Leu Ala Arg Asp Ile Leu Leu Lys Ser Gly Gly Arg 
                165                 170                 175     


Arg Ser Gly Asn Gly Asn Lys Pro Pro Ser Thr Asp Leu Lys Thr Cys 
            180                 185                 190         


Asp Lys Lys Asn Thr Asn Lys Cys Ser Leu Gly 
        195                 200             


<210>  47
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  48
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210>  49
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 
1               5                   10                  15      


Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 
            20                  25                  30          


Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 
        35                  40                  45              


Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 
    50                  55                  60                  


Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 
65                  70                  75                  80  


Val Tyr Leu Gln Gly Leu Ile Asp Cys Tyr Leu Phe Gly Asn Ser Ser 
                85                  90                  95      


Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 
            100                 105                 110         


Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 
        115                 120                 125             


Lys Tyr 
    130 


<210>  50
<211>  267
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala Arg His Phe Trp Gln Gln Asp Glu Pro Pro Gln Ser Pro Trp 
            20                  25                  30          


Asp Arg Val Lys Asp Leu Ala Thr Val Tyr Val Asp Val Leu Lys Asp 
        35                  40                  45              


Ser Gly Arg Asp Tyr Val Ser Gln Phe Glu Gly Ser Ala Leu Gly Lys 
    50                  55                  60                  


Gln Leu Asn Leu Lys Leu Leu Asp Asn Trp Asp Ser Val Thr Ser Thr 
65                  70                  75                  80  


Phe Ser Lys Leu Arg Glu Gln Leu Gly Pro Val Thr Gln Glu Phe Trp 
                85                  90                  95      


Asp Asn Leu Glu Lys Glu Thr Glu Gly Leu Arg Gln Glu Met Ser Lys 
            100                 105                 110         


Asp Leu Glu Glu Val Lys Ala Lys Val Gln Pro Tyr Leu Asp Asp Phe 
        115                 120                 125             


Gln Lys Lys Trp Gln Glu Glu Met Glu Leu Tyr Arg Gln Lys Val Glu 
    130                 135                 140                 


Pro Leu Arg Ala Glu Leu Gln Glu Gly Ala Arg Gln Lys Leu His Glu 
145                 150                 155                 160 


Leu Gln Glu Lys Leu Ser Pro Leu Gly Glu Glu Met Arg Asp Arg Ala 
                165                 170                 175     


Arg Ala His Val Asp Ala Leu Arg Thr His Leu Ala Pro Tyr Ser Asp 
            180                 185                 190         


Glu Leu Arg Gln Arg Leu Ala Ala Arg Leu Glu Ala Leu Lys Glu Asn 
        195                 200                 205             


Gly Gly Ala Arg Leu Ala Glu Tyr His Ala Lys Ala Thr Glu His Leu 
    210                 215                 220                 


Ser Thr Leu Ser Glu Lys Ala Lys Pro Ala Leu Glu Asp Leu Arg Gln 
225                 230                 235                 240 


Gly Leu Leu Pro Val Leu Glu Ser Phe Lys Val Ser Phe Leu Ser Ala 
                245                 250                 255     


Leu Glu Glu Tyr Thr Lys Lys Leu Asn Thr Gln 
            260                 265         


<210>  51
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr Ala Asp Ser Gly Glu Gly Asp Phe Leu Ala Glu Gly Gly 
            20                  25                  30          


Gly Val Arg Gly Pro Arg Val Val Glu Arg His Gln Ser Ala Cys Lys 
        35                  40                  45              


Asp Ser Asp Trp Pro Phe Cys Ser Asp Glu Asp Trp Asn Tyr Lys Cys 
    50                  55                  60                  


Pro Ser Gly Cys Arg Met Lys Gly Leu Ile Asp Glu Val Asn Gln Asp 
65                  70                  75                  80  


Phe Thr Asn Arg Ile Asn Lys Leu Lys Asn Ser Leu Phe Glu Tyr Gln 
                85                  90                  95      


Lys Asn Asn Lys Asp Ser His Ser Leu Thr Thr Asn Ile Met Glu Ile 
            100                 105                 110         


Leu Arg Gly Asp Phe Ser Ser Ala Asn Asn Arg Asp Asn Thr Tyr Asn 
        115                 120                 125             


Arg Val Ser Glu Asp Leu Arg Ser Arg Ile Glu Val Leu Lys Arg Lys 
    130                 135                 140                 


Val Ile Glu Lys Val Gln His Ile Gln Leu Leu Gln Lys Asn Val Arg 
145                 150                 155                 160 


Ala Gln Leu Val Asp Met Lys Arg Leu Glu Val Asp Ile Asp Ile Lys 
                165                 170                 175     


Ile Arg Ser Cys Arg Gly Ser Cys Ser Arg Ala Leu Ala Arg Glu Val 
            180                 185                 190         


Asp Leu Lys Asp Tyr Glu Asp Gln Gln Lys Gln Leu Glu Gln Val Ile 
        195                 200                 205             


Ala Lys Asp Leu Leu Pro Ser Arg Asp Arg Gln His Leu Pro Leu Ile 
    210                 215                 220                 


Lys Met Lys Pro Val Pro Asp Leu Val Pro Gly Asn Phe Lys Ser Gln 
225                 230                 235                 240 


Leu Gln Lys Val Pro Pro Glu Trp Lys Ala Leu Thr Asp Met Pro Gln 
                245                 250                 255     


Met Arg Met Glu Leu Glu Arg Pro Gly Gly Asn Glu Ile Thr Arg Gly 
            260                 265                 270         


Gly Ser Thr Ser Tyr Gly Thr Gly Ser Glu Thr Glu Ser Pro Arg Asn 
        275                 280                 285             


Pro Ser Ser Ala Gly Ser Trp Asn Ser Gly Ser Ser Gly Pro Gly Ser 
    290                 295                 300                 


Thr Gly Asn Arg Asn Pro Gly Ser Ser Gly Thr Gly Gly Thr Ala Thr 
305                 310                 315                 320 


Trp Lys Pro Gly Ser Ser Gly Pro Gly Ser Thr Gly Ser Trp Asn Ser 
                325                 330                 335     


Gly Ser Ser Gly Thr Gly Ser Thr Gly Asn Gln Asn Pro Gly Ser Pro 
            340                 345                 350         


Arg Pro Gly Ser Thr Gly Thr Trp Asn Pro Gly Ser Ser Glu Arg Gly 
        355                 360                 365             


Ser Ala Gly His Trp Thr Ser Glu Ser Ser Val Ser Gly Ser Thr Gly 
    370                 375                 380                 


Gln Trp His Ser Glu Ser Gly Ser Phe Arg Pro Asp Ser Pro Gly Ser 
385                 390                 395                 400 


Gly Asn Ala Arg Pro Asn Asn Pro Asp Trp Gly Thr Phe Glu Glu Val 
                405                 410                 415     


Ser Gly Asn Val Ser Pro Gly Thr Arg Arg Glu Tyr His Thr Glu Lys 
            420                 425                 430         


Leu Val Thr Ser Lys Gly Asp Lys Glu Leu Arg Thr Gly Lys Glu Lys 
        435                 440                 445             


Val Thr Ser Gly Ser Thr Thr Thr Thr Arg Arg Ser Cys Ser Lys Thr 
    450                 455                 460                 


Val Thr Lys Thr Val Ile Gly Pro Asp Gly His Lys Glu Val Thr Lys 
465                 470                 475                 480 


Glu Val Val Thr Ser Glu Asp Gly Ser Asp Cys Pro Glu Ala Met Asp 
                485                 490                 495     


Leu Gly Thr Leu Ser Gly Ile Gly Thr Leu Asp Gly Phe Arg His Arg 
            500                 505                 510         


His Pro Asp Glu Ala Ala Phe Phe Asp Thr Ala Ser Thr Gly Lys Thr 
        515                 520                 525             


Phe Pro Gly Phe Phe Ser Pro Met Leu Gly Glu Phe Val Ser Glu Thr 
    530                 535                 540                 


Glu Ser Arg Gly Ser Glu Ser Gly Ile Phe Thr Asn Thr Lys Glu Ser 
545                 550                 555                 560 


Ser Ser His His Pro Gly Ile Ala Glu Phe Pro Ser Arg Gly Lys Ser 
                565                 570                 575     


Ser Ser Tyr Ser Lys Gln Phe Thr Ser Ser Thr Ser Tyr Asn Arg Gly 
            580                 585                 590         


Asp Ser Thr Phe Glu Ser Lys Ser Tyr Lys Met Ala Asp Glu Ala Gly 
        595                 600                 605             


Ser Glu Ala Asp His Glu Gly Thr His Ser Thr Lys Arg Gly His Ala 
    610                 615                 620                 


Lys Ser Arg Pro Val Arg Asp Cys Asp Asp Val Leu Gln Thr His Pro 
625                 630                 635                 640 


Ser Gly Thr Gln Ser Gly Ile Phe Asn Ile Lys Leu Pro Gly Ser Ser 
                645                 650                 655     


Lys Ile Phe Ser Val Tyr Cys Asp Gln Glu Thr Ser Leu Gly Gly Trp 
            660                 665                 670         


Leu Leu Ile Gln Gln Arg Met Asp Gly Ser Leu Asn Phe Asn Arg Thr 
        675                 680                 685             


Trp Gln Asp Tyr Lys Arg Gly Phe Gly Ser Leu Asn Asp Glu Gly Glu 
    690                 695                 700                 


Gly Glu Phe Trp Leu Gly Asn Asp Tyr Leu His Leu Leu Thr Gln Arg 
705                 710                 715                 720 


Gly Ser Val Leu Arg Val Glu Leu Glu Asp Trp Ala Gly Asn Glu Ala 
                725                 730                 735     


Tyr Ala Glu Tyr His Phe Arg Val Gly Ser Glu Ala Glu Gly Tyr Ala 
            740                 745                 750         


Leu Gln Val Ser Ser Tyr Glu Gly Thr Ala Gly Asp Ala Leu Ile Glu 
        755                 760                 765             


Gly Ser Val Glu Glu Gly Ala Glu Tyr Thr Ser His Asn Asn Met Gln 
    770                 775                 780                 


Phe Ser Thr Phe Asp Arg Asp Ala Asp Gln Trp Glu Glu Asn Cys Ala 
785                 790                 795                 800 


Glu Val Tyr Gly Gly Gly Trp Trp Tyr Asn Asn Cys Gln Ala Ala Asn 
                805                 810                 815     


Leu Asn Gly Ile Tyr Tyr Pro Gly Gly Ser Tyr Asp Pro Arg Asn Asn 
            820                 825                 830         


Ser Pro Tyr Glu Ile Glu Asn Gly Val Val Trp Val Ser Phe Arg Gly 
        835                 840                 845             


Ala Asp Tyr Ser Leu Arg Ala Val Arg Met Lys Ile Arg Pro Leu Val 
    850                 855                 860                 


Thr Gln 
865     


<210>  52
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Ala Leu Gly Ala Val Ile Ala Leu Leu Leu Trp Gly Gln Leu 
1               5                   10                  15      


Phe Ala Val Asp Ser Gly Asn Asp Val Thr Asp Ile Ala Asp Asp Gly 
            20                  25                  30          


Cys Pro Lys Pro Pro Glu Ile Ala His Gly Tyr Val Glu His Ser Val 
        35                  40                  45              


Arg Tyr Gln Cys Lys Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly 
    50                  55                  60                  


Val Tyr Thr Leu Asn Asp Lys Lys Gln Trp Ile Asn Lys Ala Val Gly 
65                  70                  75                  80  


Asp Lys Leu Pro Glu Cys Glu Ala Asp Asp Gly Cys Pro Lys Pro Pro 
                85                  90                  95      


Glu Ile Ala His Gly Tyr Val Glu His Ser Val Arg Tyr Gln Cys Lys 
            100                 105                 110         


Asn Tyr Tyr Lys Leu Arg Thr Glu Gly Asp Gly Val Tyr Thr Leu Asn 
        115                 120                 125             


Asn Glu Lys Gln Trp Ile Asn Lys Ala Val Gly Asp Lys Leu Pro Glu 
    130                 135                 140                 


Cys Glu Ala Val Cys Gly Lys Pro Lys Asn Pro Ala Asn Pro Val Gln 
145                 150                 155                 160 


Arg Ile Leu Gly Gly His Leu Asp Ala Lys Gly Ser Phe Pro Trp Gln 
                165                 170                 175     


Ala Lys Met Val Ser His His Asn Leu Thr Thr Gly Ala Thr Leu Ile 
            180                 185                 190         


Asn Glu Gln Trp Leu Leu Thr Thr Ala Lys Asn Leu Phe Leu Asn His 
        195                 200                 205             


Ser Glu Asn Ala Thr Ala Lys Asp Ile Ala Pro Thr Leu Thr Leu Tyr 
    210                 215                 220                 


Val Gly Lys Lys Gln Leu Val Glu Ile Glu Lys Val Val Leu His Pro 
225                 230                 235                 240 


Asn Tyr Ser Gln Val Asp Ile Gly Leu Ile Lys Leu Lys Gln Lys Val 
                245                 250                 255     


Ser Val Asn Glu Arg Val Met Pro Ile Cys Leu Pro Ser Lys Asp Tyr 
            260                 265                 270         


Ala Glu Val Gly Arg Val Gly Tyr Val Ser Gly Trp Gly Arg Asn Ala 
        275                 280                 285             


Asn Phe Lys Phe Thr Asp His Leu Lys Tyr Val Met Leu Pro Val Ala 
    290                 295                 300                 


Asp Gln Asp Gln Cys Ile Arg His Tyr Glu Gly Ser Thr Val Pro Glu 
305                 310                 315                 320 


Lys Lys Thr Pro Lys Ser Pro Val Gly Val Gln Pro Ile Leu Asn Glu 
                325                 330                 335     


His Thr Phe Cys Ala Gly Met Ser Lys Tyr Gln Glu Asp Thr Cys Tyr 
            340                 345                 350         


Gly Asp Ala Gly Ser Ala Phe Ala Val His Asp Leu Glu Glu Asp Thr 
        355                 360                 365             


Trp Tyr Ala Thr Gly Ile Leu Ser Phe Asp Lys Ser Cys Ala Val Ala 
    370                 375                 380                 


Glu Tyr Gly Val Tyr Val Lys Val Thr Ser Ile Gln Asp Trp Val Gln 
385                 390                 395                 400 


Lys Thr Ile Ala Glu Asn 
                405     


<210>  53
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210>  54
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 
                405                 410                 415     


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
            420                 425                 430         


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
        435                 440                 445             


Gly Thr Cys Tyr 
    450         


<210>  55
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Val His Leu Thr Pro Glu Glu Lys Thr Ala Val Asn Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Ala Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Ser Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ser Gln Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala Arg Asn Phe Gly Lys Glu Phe Thr Pro Gln Met Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  56
<211>  5405
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly Ala Leu Trp Ser Trp Trp Ile Leu Trp Ala Gly Ala Thr Leu 
1               5                   10                  15      


Leu Trp Gly Leu Thr Gln Glu Ala Ser Val Asp Leu Lys Asn Thr Gly 
            20                  25                  30          


Arg Glu Glu Phe Leu Thr Ala Phe Leu Gln Asn Tyr Gln Leu Ala Tyr 
        35                  40                  45              


Ser Lys Ala Tyr Pro Arg Leu Leu Ile Ser Ser Leu Ser Glu Ser Pro 
    50                  55                  60                  


Ala Ser Val Ser Ile Leu Ser Gln Ala Asp Asn Thr Ser Lys Lys Val 
65                  70                  75                  80  


Thr Val Arg Pro Gly Glu Ser Val Met Val Asn Ile Ser Ala Lys Ala 
                85                  90                  95      


Glu Met Ile Gly Ser Lys Ile Phe Gln His Ala Val Val Ile His Ser 
            100                 105                 110         


Asp Tyr Ala Ile Ser Val Gln Ala Leu Asn Ala Lys Pro Asp Thr Ala 
        115                 120                 125             


Glu Leu Thr Leu Leu Arg Pro Ile Gln Ala Leu Gly Thr Glu Tyr Phe 
    130                 135                 140                 


Val Leu Thr Pro Pro Gly Thr Ser Ala Arg Asn Val Lys Glu Phe Ala 
145                 150                 155                 160 


Val Val Ala Gly Ala Ala Gly Ala Ser Val Ser Val Thr Leu Lys Gly 
                165                 170                 175     


Ser Val Thr Phe Asn Gly Lys Phe Tyr Pro Ala Gly Asp Val Leu Arg 
            180                 185                 190         


Val Thr Leu Gln Pro Tyr Asn Val Ala Gln Leu Gln Ser Ser Val Asp 
        195                 200                 205             


Leu Ser Gly Ser Lys Val Thr Ala Ser Ser Pro Val Ala Val Leu Ser 
    210                 215                 220                 


Gly His Ser Cys Ala Gln Lys His Thr Thr Cys Asn His Val Val Glu 
225                 230                 235                 240 


Gln Leu Leu Pro Thr Ser Ala Trp Gly Thr His Tyr Val Val Pro Thr 
                245                 250                 255     


Leu Ala Ser Gln Ser Arg Tyr Asp Leu Ala Phe Val Val Ala Ser Gln 
            260                 265                 270         


Ala Thr Lys Leu Thr Tyr Asn His Gly Gly Ile Thr Gly Ser Arg Gly 
        275                 280                 285             


Leu Gln Ala Gly Asp Val Val Glu Phe Glu Val Arg Pro Ser Trp Pro 
    290                 295                 300                 


Leu Tyr Leu Ser Ala Asn Val Gly Ile Gln Val Leu Leu Phe Gly Thr 
305                 310                 315                 320 


Gly Ala Ile Arg Asn Glu Val Thr Tyr Asp Pro Tyr Leu Val Leu Ile 
                325                 330                 335     


Pro Asp Val Ala Ala Tyr Cys Pro Ala Tyr Val Val Lys Ser Val Pro 
            340                 345                 350         


Gly Cys Glu Gly Val Ala Leu Val Val Ala Gln Thr Lys Ala Ile Ser 
        355                 360                 365             


Gly Leu Thr Ile Asp Gly His Ala Val Gly Ala Lys Leu Thr Trp Glu 
    370                 375                 380                 


Ala Val Pro Gly Ser Glu Phe Ser Tyr Ala Glu Val Glu Leu Gly Thr 
385                 390                 395                 400 


Ala Asp Met Ile His Thr Ala Glu Ala Thr Thr Asn Leu Gly Leu Leu 
                405                 410                 415     


Thr Phe Gly Leu Ala Lys Ala Ile Gly Tyr Ala Thr Ala Ala Asp Cys 
            420                 425                 430         


Gly Arg Thr Val Leu Ser Pro Val Glu Pro Ser Cys Glu Gly Met Gln 
        435                 440                 445             


Cys Ala Ala Gly Gln Arg Cys Gln Val Val Gly Gly Lys Ala Gly Cys 
    450                 455                 460                 


Val Ala Glu Ser Thr Ala Val Cys Arg Ala Gln Gly Asp Pro His Tyr 
465                 470                 475                 480 


Thr Thr Phe Asp Gly Arg Arg Tyr Asp Met Met Gly Thr Cys Ser Tyr 
                485                 490                 495     


Thr Met Val Glu Leu Cys Ser Glu Asp Asp Thr Leu Pro Ala Phe Ser 
            500                 505                 510         


Val Glu Ala Lys Asn Glu His Arg Gly Ser Arg Arg Val Ser Tyr Val 
        515                 520                 525             


Gly Leu Val Thr Val Arg Ala Tyr Ser His Ser Val Ser Leu Thr Arg 
    530                 535                 540                 


Gly Glu Val Gly Phe Val Leu Val Asp Asn Gln Arg Ser Arg Leu Pro 
545                 550                 555                 560 


Val Ser Leu Ser Glu Gly Arg Leu Arg Val Tyr Gln Ser Gly Pro Arg 
                565                 570                 575     


Ala Val Val Glu Leu Val Phe Gly Leu Val Val Thr Tyr Asp Trp Asp 
            580                 585                 590         


Cys Gln Leu Ala Leu Ser Leu Pro Ala Arg Phe Gln Asp Gln Val Cys 
        595                 600                 605             


Gly Leu Cys Gly Asn Tyr Asn Gly Asp Pro Ala Asp Asp Phe Leu Thr 
    610                 615                 620                 


Pro Asp Gly Ala Leu Ala Pro Asp Ala Val Glu Phe Ala Ser Ser Trp 
625                 630                 635                 640 


Lys Leu Asp Asp Gly Asp Tyr Leu Cys Glu Asp Gly Cys Gln Asn Asn 
                645                 650                 655     


Cys Pro Ala Cys Thr Pro Gly Gln Ala Gln His Tyr Glu Gly Asp Arg 
            660                 665                 670         


Leu Cys Gly Met Leu Thr Lys Leu Asp Gly Pro Phe Ala Val Cys His 
        675                 680                 685             


Asp Thr Leu Asp Pro Arg Pro Phe Leu Glu Gln Cys Val Tyr Asp Leu 
    690                 695                 700                 


Cys Val Val Gly Gly Glu Arg Leu Ser Leu Cys Arg Gly Leu Ser Ala 
705                 710                 715                 720 


Tyr Ala Gln Ala Cys Leu Glu Leu Gly Ile Ser Val Gly Asp Trp Arg 
                725                 730                 735     


Ser Pro Ala Asn Cys Pro Leu Ser Cys Pro Ala Asn Ser Arg Tyr Glu 
            740                 745                 750         


Leu Cys Gly Pro Ala Cys Pro Thr Ser Cys Asn Gly Ala Ala Ala Pro 
        755                 760                 765             


Ser Asn Cys Ser Gly Arg Pro Cys Val Glu Gly Cys Val Cys Leu Pro 
    770                 775                 780                 


Gly Phe Val Ala Ser Gly Gly Ala Cys Val Pro Ala Ser Ser Cys Gly 
785                 790                 795                 800 


Cys Thr Phe Gln Gly Leu Gln Leu Ala Pro Gly Gln Glu Val Trp Ala 
                805                 810                 815     


Asp Glu Leu Cys Gln Arg Arg Cys Thr Cys Asn Gly Ala Thr His Gln 
            820                 825                 830         


Val Thr Cys Arg Asp Lys Gln Ser Cys Pro Ala Gly Glu Arg Cys Ser 
        835                 840                 845             


Val Gln Asn Gly Leu Leu Gly Cys Tyr Pro Asp Arg Phe Gly Thr Cys 
    850                 855                 860                 


Gln Gly Ser Gly Asp Pro His Tyr Val Ser Phe Asp Gly Arg Arg Phe 
865                 870                 875                 880 


Asp Phe Met Gly Thr Cys Thr Tyr Leu Leu Val Gly Ser Cys Gly Gln 
                885                 890                 895     


Asn Ala Ala Leu Pro Ala Phe Arg Val Leu Val Glu Asn Glu His Arg 
            900                 905                 910         


Gly Ser Gln Thr Val Ser Tyr Thr Arg Ala Val Arg Val Glu Ala Arg 
        915                 920                 925             


Gly Val Lys Val Ala Val Arg Arg Glu Tyr Pro Gly Gln Val Leu Val 
    930                 935                 940                 


Asp Asp Val Leu Gln Tyr Leu Pro Phe Gln Ala Ala Asp Gly Gln Val 
945                 950                 955                 960 


Gln Val Phe Arg Gln Gly Arg Asp Ala Val Val Arg Thr Asp Phe Gly 
                965                 970                 975     


Leu Thr Val Thr Tyr Asp Trp Asn Ala Arg Val Thr Ala Lys Val Pro 
            980                 985                 990         


Ser Ser Tyr Ala Glu Ala Leu Cys  Gly Leu Cys Gly Asn  Phe Asn Gly 
        995                 1000                 1005             


Asp Pro  Ala Asp Asp Leu Ala  Leu Arg Gly Gly Gly  Gln Ala Ala 
    1010                 1015                 1020             


Asn Ala  Leu Ala Phe Gly Asn  Ser Trp Gln Glu Glu  Thr Arg Pro 
    1025                 1030                 1035             


Gly Cys  Gly Ala Thr Glu Pro  Gly Asp Cys Pro Lys  Leu Asp Ser 
    1040                 1045                 1050             


Leu Val  Ala Gln Gln Leu Gln  Ser Lys Asn Glu Cys  Gly Ile Leu 
    1055                 1060                 1065             


Ala Asp  Pro Lys Gly Pro Phe  Arg Glu Cys His Ser  Lys Leu Asp 
    1070                 1075                 1080             


Pro Gln  Gly Ala Val Arg Asp  Cys Val Tyr Asp Arg  Cys Leu Leu 
    1085                 1090                 1095             


Pro Gly  Gln Ser Gly Pro Leu  Cys Asp Ala Leu Ala  Thr Tyr Ala 
    1100                 1105                 1110             


Ala Ala  Cys Gln Ala Ala Gly  Ala Thr Val His Pro  Trp Arg Ser 
    1115                 1120                 1125             


Glu Glu  Leu Cys Pro Leu Ser  Cys Pro Pro His Ser  His Tyr Glu 
    1130                 1135                 1140             


Ala Cys  Ser Tyr Gly Cys Pro  Leu Ser Cys Gly Asp  Leu Pro Val 
    1145                 1150                 1155             


Pro Gly  Gly Cys Gly Ser Glu  Cys His Glu Gly Cys  Val Cys Asp 
    1160                 1165                 1170             


Glu Gly  Phe Ala Leu Ser Gly  Glu Ser Cys Leu Pro  Leu Ala Ser 
    1175                 1180                 1185             


Cys Gly  Cys Val His Gln Gly  Thr Tyr His Pro Pro  Gly Gln Thr 
    1190                 1195                 1200             


Phe Tyr  Pro Gly Pro Gly Cys  Asp Ser Leu Cys His  Cys Gln Glu 
    1205                 1210                 1215             


Gly Gly  Leu Val Ser Cys Glu  Ser Ser Ser Cys Gly  Pro His Glu 
    1220                 1225                 1230             


Ala Cys  Gln Pro Ser Gly Gly  Ser Leu Gly Cys Val  Ala Val Gly 
    1235                 1240                 1245             


Ser Ser  Thr Cys Gln Ala Ser  Gly Asp Pro His Tyr  Thr Thr Phe 
    1250                 1255                 1260             


Asp Gly  Arg Arg Phe Asp Phe  Met Gly Thr Cys Val  Tyr Val Leu 
    1265                 1270                 1275             


Ala Gln  Thr Cys Gly Thr Arg  Pro Gly Leu His Arg  Phe Ala Val 
    1280                 1285                 1290             


Leu Gln  Glu Asn Val Ala Trp  Gly Asn Gly Arg Val  Ser Val Thr 
    1295                 1300                 1305             


Arg Val  Ile Thr Val Gln Val  Ala Asn Phe Thr Leu  Arg Leu Glu 
    1310                 1315                 1320             


Gln Arg  Gln Trp Lys Val Thr  Val Asn Gly Val Asp  Met Lys Leu 
    1325                 1330                 1335             


Pro Val  Val Leu Ala Asn Gly  Gln Ile Arg Ala Ser  Gln His Gly 
    1340                 1345                 1350             


Ser Asp  Val Val Ile Glu Thr  Asp Phe Gly Leu Arg  Val Ala Tyr 
    1355                 1360                 1365             


Asp Leu  Val Tyr Tyr Val Arg  Val Thr Val Pro Gly  Asn Tyr Tyr 
    1370                 1375                 1380             


Gln Gln  Met Cys Gly Leu Cys  Gly Asn Tyr Asn Gly  Asp Pro Lys 
    1385                 1390                 1395             


Asp Asp  Phe Gln Lys Pro Asn  Gly Ser Gln Ala Gly  Asn Ala Asn 
    1400                 1405                 1410             


Glu Phe  Gly Asn Ser Trp Glu  Glu Val Val Pro Asp  Ser Pro Cys 
    1415                 1420                 1425             


Leu Pro  Pro Thr Pro Cys Pro  Pro Gly Ser Glu Asp  Cys Ile Pro 
    1430                 1435                 1440             


Ser His  Lys Cys Pro Pro Glu  Leu Glu Lys Lys Tyr  Gln Lys Glu 
    1445                 1450                 1455             


Glu Phe  Cys Gly Leu Leu Ser  Ser Pro Thr Gly Pro  Leu Ser Ser 
    1460                 1465                 1470             


Cys His  Lys Leu Val Asp Pro  Gln Gly Pro Leu Lys  Asp Cys Ile 
    1475                 1480                 1485             


Phe Asp  Leu Cys Leu Gly Gly  Gly Asn Leu Ser Ile  Leu Cys Ser 
    1490                 1495                 1500             


Asn Ile  His Ala Tyr Val Ser  Ala Cys Gln Ala Ala  Gly Gly His 
    1505                 1510                 1515             


Val Glu  Pro Trp Arg Thr Glu  Thr Phe Cys Pro Met  Glu Cys Pro 
    1520                 1525                 1530             


Pro Asn  Ser His Tyr Glu Leu  Cys Ala Asp Thr Cys  Ser Leu Gly 
    1535                 1540                 1545             


Cys Ser  Ala Leu Ser Ala Pro  Pro Gln Cys Gln Asp  Gly Cys Ala 
    1550                 1555                 1560             


Glu Gly  Cys Gln Cys Asp Ser  Gly Phe Leu Tyr Asn  Gly Gln Ala 
    1565                 1570                 1575             


Cys Val  Pro Ile Gln Gln Cys  Gly Cys Tyr His Asn  Gly Val Tyr 
    1580                 1585                 1590             


Tyr Glu  Pro Glu Gln Thr Val  Leu Ile Asp Asn Cys  Arg Gln Gln 
    1595                 1600                 1605             


Cys Thr  Cys His Ala Gly Lys  Gly Met Val Cys Gln  Glu His Ser 
    1610                 1615                 1620             


Cys Lys  Pro Gly Gln Val Cys  Gln Pro Ser Gly Gly  Ile Leu Ser 
    1625                 1630                 1635             


Cys Val  Thr Lys Asp Pro Cys  His Gly Val Thr Cys  Arg Pro Gln 
    1640                 1645                 1650             


Glu Thr  Cys Lys Glu Gln Gly  Gly Gln Gly Val Cys  Leu Pro Asn 
    1655                 1660                 1665             


Tyr Glu  Ala Thr Cys Trp Leu  Trp Gly Asp Pro His  Tyr His Ser 
    1670                 1675                 1680             


Phe Asp  Gly Arg Lys Phe Asp  Phe Gln Gly Thr Cys  Asn Tyr Val 
    1685                 1690                 1695             


Leu Ala  Thr Thr Gly Cys Pro  Gly Val Ser Thr Gln  Gly Leu Thr 
    1700                 1705                 1710             


Pro Phe  Thr Val Thr Thr Lys  Asn Gln Asn Arg Gly  Asn Pro Ala 
    1715                 1720                 1725             


Val Ser  Tyr Val Arg Val Val  Thr Val Ala Ala Leu  Gly Thr Asn 
    1730                 1735                 1740             


Ile Ser  Ile His Lys Asp Glu  Ile Gly Lys Val Arg  Val Asn Gly 
    1745                 1750                 1755             


Val Leu  Thr Ala Leu Pro Val  Ser Val Ala Asp Gly  Arg Ile Ser 
    1760                 1765                 1770             


Val Thr  Gln Gly Ala Ser Lys  Ala Leu Leu Val Ala  Asp Phe Gly 
    1775                 1780                 1785             


Leu Gln  Val Ser Tyr Asp Trp  Asn Trp Arg Val Asp  Val Thr Leu 
    1790                 1795                 1800             


Pro Ser  Ser Tyr His Gly Ala  Val Cys Gly Leu Cys  Gly Asn Met 
    1805                 1810                 1815             


Asp Arg  Asn Pro Asn Asn Asp  Gln Val Phe Pro Asn  Gly Thr Leu 
    1820                 1825                 1830             


Ala Pro  Ser Ile Pro Ile Trp  Gly Gly Ser Trp Arg  Ala Pro Gly 
    1835                 1840                 1845             


Trp Asp  Pro Leu Cys Trp Asp  Glu Cys Arg Gly Ser  Cys Pro Thr 
    1850                 1855                 1860             


Cys Pro  Glu Asp Arg Leu Glu  Gln Tyr Glu Gly Pro  Gly Phe Cys 
    1865                 1870                 1875             


Gly Pro  Leu Ala Pro Gly Thr  Gly Gly Pro Phe Thr  Thr Cys His 
    1880                 1885                 1890             


Ala His  Val Pro Pro Glu Ser  Phe Phe Lys Gly Cys  Val Leu Asp 
    1895                 1900                 1905             


Val Cys  Met Gly Gly Gly Asp  Arg Asp Ile Leu Cys  Lys Ala Leu 
    1910                 1915                 1920             


Ala Ser  Tyr Val Ala Ala Cys  Gln Ala Ala Gly Val  Val Ile Glu 
    1925                 1930                 1935             


Asp Trp  Arg Ala Gln Val Gly  Cys Glu Ile Thr Cys  Pro Glu Asn 
    1940                 1945                 1950             


Ser His  Tyr Glu Val Cys Gly  Ser Pro Cys Pro Ala  Ser Cys Pro 
    1955                 1960                 1965             


Ser Pro  Ala Pro Leu Thr Thr  Pro Ala Val Cys Glu  Gly Pro Cys 
    1970                 1975                 1980             


Val Glu  Gly Cys Gln Cys Asp  Ala Gly Phe Val Leu  Ser Ala Asp 
    1985                 1990                 1995             


Arg Cys  Val Pro Leu Asn Asn  Gly Cys Gly Cys Trp  Ala Asn Gly 
    2000                 2005                 2010             


Thr Tyr  His Glu Ala Gly Ser  Glu Phe Trp Ala Asp  Gly Thr Cys 
    2015                 2020                 2025             


Ser Gln  Trp Cys Arg Cys Gly  Pro Gly Gly Gly Ser  Leu Val Cys 
    2030                 2035                 2040             


Thr Pro  Ala Ser Cys Gly Leu  Gly Glu Val Cys Gly  Leu Leu Pro 
    2045                 2050                 2055             


Ser Gly  Gln His Gly Cys Gln  Pro Val Ser Thr Ala  Glu Cys Gln 
    2060                 2065                 2070             


Ala Trp  Gly Asp Pro His Tyr  Val Thr Leu Asp Gly  His Arg Phe 
    2075                 2080                 2085             


Asn Phe  Gln Gly Thr Cys Glu  Tyr Leu Leu Ser Ala  Pro Cys His 
    2090                 2095                 2100             


Gly Pro  Pro Leu Gly Ala Glu  Asn Phe Thr Val Thr  Val Ala Asn 
    2105                 2110                 2115             


Glu His  Arg Gly Ser Gln Ala  Val Ser Tyr Thr Arg  Ser Val Thr 
    2120                 2125                 2130             


Leu Gln  Ile Tyr Asn His Ser  Leu Thr Leu Ser Ala  Arg Trp Pro 
    2135                 2140                 2145             


Arg Lys  Leu Gln Val Asp Gly  Val Phe Val Thr Leu  Pro Phe Gln 
    2150                 2155                 2160             


Leu Asp  Ser Leu Leu His Ala  His Leu Ser Gly Ala  Asp Val Val 
    2165                 2170                 2175             


Val Thr  Thr Thr Ser Gly Leu  Ser Leu Ala Phe Asp  Gly Asp Ser 
    2180                 2185                 2190             


Phe Val  Arg Leu Arg Val Pro  Ala Ala Tyr Ala Gly  Ser Leu Cys 
    2195                 2200                 2205             


Gly Leu  Cys Gly Asn Tyr Asn  Gln Asp Pro Ala Asp  Asp Leu Lys 
    2210                 2215                 2220             


Ala Val  Gly Gly Lys Pro Ala  Gly Trp Gln Val Gly  Gly Ala Gln 
    2225                 2230                 2235             


Gly Cys  Gly Glu Cys Val Ser  Lys Pro Cys Pro Ser  Pro Cys Thr 
    2240                 2245                 2250             


Pro Glu  Gln Gln Glu Ser Phe  Gly Gly Pro Asp Ala  Cys Gly Val 
    2255                 2260                 2265             


Ile Ser  Ala Thr Asp Gly Pro  Leu Ala Pro Cys His  Gly Leu Val 
    2270                 2275                 2280             


Pro Pro  Ala Gln Tyr Phe Gln  Gly Cys Leu Leu Asp  Ala Cys Gln 
    2285                 2290                 2295             


Val Gln  Gly His Pro Gly Gly  Leu Cys Pro Ala Val  Ala Thr Tyr 
    2300                 2305                 2310             


Val Ala  Ala Cys Gln Ala Ala  Gly Ala Gln Leu Arg  Glu Trp Arg 
    2315                 2320                 2325             


Arg Pro  Asp Phe Cys Pro Phe  Gln Cys Pro Ala His  Ser His Tyr 
    2330                 2335                 2340             


Glu Leu  Cys Gly Asp Ser Cys  Pro Gly Ser Cys Pro  Ser Leu Ser 
    2345                 2350                 2355             


Ala Pro  Glu Gly Cys Glu Ser  Ala Cys Arg Glu Gly  Cys Val Cys 
    2360                 2365                 2370             


Asp Ala  Gly Phe Val Leu Ser  Gly Asp Thr Cys Val  Pro Val Gly 
    2375                 2380                 2385             


Gln Cys  Gly Cys Leu His Asp  Asp Arg Tyr Tyr Pro  Leu Gly Gln 
    2390                 2395                 2400             


Thr Phe  Tyr Pro Gly Pro Gly  Cys Asp Ser Leu Cys  Arg Cys Arg 
    2405                 2410                 2415             


Glu Gly  Gly Glu Val Ser Cys  Glu Pro Ser Ser Cys  Gly Pro His 
    2420                 2425                 2430             


Glu Thr  Cys Arg Pro Ser Gly  Gly Ser Leu Gly Cys  Val Ala Val 
    2435                 2440                 2445             


Gly Ser  Thr Thr Cys Gln Ala  Ser Gly Asp Pro His  Tyr Thr Thr 
    2450                 2455                 2460             


Phe Asp  Gly Arg Arg Phe Asp  Phe Met Gly Thr Cys  Val Tyr Val 
    2465                 2470                 2475             


Leu Ala  Gln Thr Cys Gly Thr  Arg Pro Gly Leu His  Arg Phe Ala 
    2480                 2485                 2490             


Val Leu  Gln Glu Asn Val Ala  Trp Gly Asn Gly Arg  Val Ser Val 
    2495                 2500                 2505             


Thr Arg  Val Ile Thr Val Gln  Val Ala Asn Phe Thr  Leu Arg Leu 
    2510                 2515                 2520             


Glu Gln  Arg Gln Trp Lys Val  Thr Val Asn Gly Val  Asp Met Lys 
    2525                 2530                 2535             


Leu Pro  Val Val Leu Ala Asn  Gly Gln Ile Arg Ala  Ser Gln His 
    2540                 2545                 2550             


Gly Ser  Asp Val Val Ile Glu  Thr Asp Phe Gly Leu  Arg Val Ala 
    2555                 2560                 2565             


Tyr Asp  Leu Val Tyr Tyr Val  Arg Val Thr Val Pro  Gly Asn Tyr 
    2570                 2575                 2580             


Tyr Gln  Leu Met Cys Gly Leu  Cys Gly Asn Tyr Asn  Gly Asp Pro 
    2585                 2590                 2595             


Lys Asp  Asp Phe Gln Lys Pro  Asn Gly Ser Gln Ala  Gly Asn Ala 
    2600                 2605                 2610             


Asn Glu  Phe Gly Asn Ser Trp  Glu Glu Val Val Pro  Asp Ser Pro 
    2615                 2620                 2625             


Cys Leu  Pro Pro Pro Thr Cys  Pro Pro Gly Ser Glu  Gly Cys Ile 
    2630                 2635                 2640             


Pro Ser  Glu Glu Cys Pro Pro  Glu Leu Glu Lys Lys  Tyr Gln Lys 
    2645                 2650                 2655             


Glu Glu  Phe Cys Gly Leu Leu  Ser Ser Pro Thr Gly  Pro Leu Ser 
    2660                 2665                 2670             


Ser Cys  His Lys Leu Val Asp  Pro Gln Gly Pro Leu  Lys Asp Cys 
    2675                 2680                 2685             


Ile Phe  Asp Leu Cys Leu Gly  Gly Gly Asn Leu Ser  Ile Leu Cys 
    2690                 2695                 2700             


Ser Asn  Ile His Ala Tyr Val  Ser Ala Cys Gln Ala  Ala Gly Gly 
    2705                 2710                 2715             


Gln Val  Glu Pro Trp Arg Asn  Glu Thr Phe Cys Pro  Met Glu Cys 
    2720                 2725                 2730             


Pro Gln  Asn Ser His Tyr Glu  Leu Cys Ala Asp Thr  Cys Ser Leu 
    2735                 2740                 2745             


Gly Cys  Ser Ala Leu Ser Ala  Pro Leu Gln Cys Pro  Asp Gly Cys 
    2750                 2755                 2760             


Ala Glu  Gly Cys Gln Cys Asp  Ser Gly Phe Leu Tyr  Asn Gly Gln 
    2765                 2770                 2775             


Ala Cys  Val Pro Ile Gln Gln  Cys Gly Cys Tyr His  Asn Gly Ala 
    2780                 2785                 2790             


Tyr Tyr  Glu Pro Glu Gln Thr  Val Leu Ile Asp Asn  Cys Arg Gln 
    2795                 2800                 2805             


Gln Cys  Thr Cys His Val Gly  Lys Val Val Val Cys  Gln Glu His 
    2810                 2815                 2820             


Ser Cys  Lys Pro Gly Gln Val  Cys Gln Pro Ser Gly  Gly Ile Leu 
    2825                 2830                 2835             


Ser Cys  Val Asn Lys Asp Pro  Cys His Gly Val Thr  Cys Arg Pro 
    2840                 2845                 2850             


Gln Glu  Thr Cys Lys Glu Gln  Gly Gly Gln Gly Val  Cys Leu Pro 
    2855                 2860                 2865             


Asn Tyr  Glu Ala Thr Cys Trp  Leu Trp Gly Asp Pro  His Tyr His 
    2870                 2875                 2880             


Ser Phe  Asp Gly Arg Lys Phe  Asp Phe Gln Gly Thr  Cys Asn Tyr 
    2885                 2890                 2895             


Val Leu  Ala Thr Thr Gly Cys  Pro Gly Val Ser Thr  Gln Gly Leu 
    2900                 2905                 2910             


Thr Pro  Phe Thr Val Thr Thr  Lys Asn Gln Asn Arg  Gly Asn Pro 
    2915                 2920                 2925             


Ala Val  Ser Tyr Val Arg Val  Val Thr Val Ala Ala  Leu Gly Thr 
    2930                 2935                 2940             


Asn Ile  Ser Ile His Lys Asp  Glu Ile Gly Lys Val  Arg Val Asn 
    2945                 2950                 2955             


Gly Val  Leu Thr Ala Leu Pro  Val Ser Val Ala Asp  Gly Arg Ile 
    2960                 2965                 2970             


Ser Val  Thr Gln Gly Ala Ser  Lys Ala Leu Leu Val  Ala Asp Phe 
    2975                 2980                 2985             


Gly Leu  Gln Val Ser Tyr Asp  Trp Asn Trp Arg Val  Asp Val Thr 
    2990                 2995                 3000             


Leu Pro  Ser Ser Tyr His Gly  Ala Val Cys Gly Leu  Cys Gly Asn 
    3005                 3010                 3015             


Met Asp  Arg Asn Pro Asn Asn  Asp Gln Val Phe Pro  Asn Gly Thr 
    3020                 3025                 3030             


Leu Ala  Pro Ser Ile Pro Ile  Trp Gly Gly Ser Trp  Arg Ala Pro 
    3035                 3040                 3045             


Gly Trp  Asp Pro Leu Cys Trp  Asp Glu Cys Arg Gly  Ser Cys Pro 
    3050                 3055                 3060             


Thr Cys  Pro Glu Asp Arg Leu  Glu Gln Tyr Glu Gly  Pro Gly Phe 
    3065                 3070                 3075             


Cys Gly  Pro Leu Ala Pro Gly  Thr Gly Gly Pro Phe  Thr Thr Cys 
    3080                 3085                 3090             


His Ala  His Val Pro Pro Glu  Ser Phe Phe Lys Gly  Cys Val Leu 
    3095                 3100                 3105             


Asp Val  Cys Met Gly Gly Gly  Asp Arg Asp Ile Leu  Cys Lys Ala 
    3110                 3115                 3120             


Leu Ala  Ser Tyr Val Ala Ala  Cys Gln Ala Ala Gly  Val Val Ile 
    3125                 3130                 3135             


Glu Asp  Trp Arg Ala Gln Val  Gly Cys Glu Ile Thr  Cys Pro Glu 
    3140                 3145                 3150             


Asn Ser  His Tyr Glu Val Cys  Gly Pro Pro Cys Pro  Ala Ser Cys 
    3155                 3160                 3165             


Pro Ser  Pro Ala Pro Leu Thr  Thr Pro Ala Val Cys  Glu Gly Pro 
    3170                 3175                 3180             


Cys Val  Glu Gly Cys Gln Cys  Asp Ala Gly Phe Val  Leu Ser Ala 
    3185                 3190                 3195             


Asp Arg  Cys Val Pro Leu Asn  Asn Gly Cys Gly Cys  Trp Ala Asn 
    3200                 3205                 3210             


Gly Thr  Tyr His Glu Ala Gly  Ser Glu Phe Trp Ala  Asp Gly Thr 
    3215                 3220                 3225             


Cys Ser  Gln Trp Cys Arg Cys  Gly Pro Gly Gly Gly  Ser Leu Val 
    3230                 3235                 3240             


Cys Thr  Pro Ala Ser Cys Gly  Leu Gly Glu Val Cys  Gly Leu Leu 
    3245                 3250                 3255             


Pro Ser  Gly Gln His Gly Cys  Gln Pro Val Ser Thr  Ala Glu Cys 
    3260                 3265                 3270             


Gln Ala  Trp Gly Asp Pro His  Tyr Val Thr Leu Asp  Gly His Arg 
    3275                 3280                 3285             


Phe Asp  Phe Gln Gly Thr Cys  Glu Tyr Leu Leu Ser  Ala Pro Cys 
    3290                 3295                 3300             


His Gly  Pro Pro Leu Gly Ala  Glu Asn Phe Thr Val  Thr Val Ala 
    3305                 3310                 3315             


Asn Glu  His Arg Gly Ser Gln  Ala Val Ser Tyr Thr  Arg Ser Val 
    3320                 3325                 3330             


Thr Leu  Gln Ile Tyr Asn His  Ser Leu Thr Leu Ser  Ala Arg Trp 
    3335                 3340                 3345             


Pro Arg  Lys Leu Gln Val Asp  Gly Val Phe Val Thr  Leu Pro Phe 
    3350                 3355                 3360             


Gln Leu  Asp Ser Leu Leu His  Ala His Leu Ser Gly  Ala Asp Val 
    3365                 3370                 3375             


Val Val  Thr Thr Thr Ser Gly  Leu Ser Leu Ala Phe  Asp Gly Asp 
    3380                 3385                 3390             


Ser Phe  Val Arg Leu Arg Val  Pro Ala Ala Tyr Ala  Gly Ser Leu 
    3395                 3400                 3405             


Cys Gly  Leu Cys Gly Asn Tyr  Asn Gln Asp Pro Ala  Asp Asp Leu 
    3410                 3415                 3420             


Lys Ala  Val Gly Gly Lys Pro  Ala Gly Trp Gln Val  Gly Gly Ala 
    3425                 3430                 3435             


Gln Gly  Cys Gly Glu Cys Val  Ser Lys Pro Cys Pro  Ser Pro Cys 
    3440                 3445                 3450             


Thr Pro  Glu Gln Gln Glu Ser  Phe Gly Gly Pro Asp  Ala Cys Gly 
    3455                 3460                 3465             


Val Ile  Ser Ala Thr Asp Gly  Pro Leu Ala Pro Cys  His Gly Leu 
    3470                 3475                 3480             


Val Pro  Pro Ala Gln Tyr Phe  Gln Gly Cys Leu Leu  Asp Ala Cys 
    3485                 3490                 3495             


Gln Val  Gln Gly His Pro Gly  Gly Leu Cys Pro Ala  Val Ala Thr 
    3500                 3505                 3510             


Tyr Val  Ala Ala Cys Gln Ala  Ala Gly Ala Gln Leu  Arg Glu Trp 
    3515                 3520                 3525             


Arg Arg  Pro Asp Phe Cys Pro  Phe Gln Cys Pro Ala  His Ser His 
    3530                 3535                 3540             


Tyr Glu  Leu Cys Gly Asp Ser  Cys Pro Gly Ser Cys  Pro Ser Leu 
    3545                 3550                 3555             


Ser Ala  Pro Glu Gly Cys Glu  Ser Ala Cys Arg Glu  Gly Cys Val 
    3560                 3565                 3570             


Cys Asp  Ala Gly Phe Val Leu  Ser Gly Asp Thr Cys  Val Pro Val 
    3575                 3580                 3585             


Gly Gln  Cys Gly Cys Leu His  Asp Asp Arg Tyr Tyr  Pro Leu Gly 
    3590                 3595                 3600             


Gln Thr  Phe Tyr Pro Gly Pro  Gly Cys Asp Ser Leu  Cys Arg Cys 
    3605                 3610                 3615             


Arg Glu  Gly Gly Glu Val Ser  Cys Glu Pro Ser Ser  Cys Gly Pro 
    3620                 3625                 3630             


His Glu  Thr Cys Arg Pro Ser  Gly Gly Ser Leu Gly  Cys Val Ala 
    3635                 3640                 3645             


Val Gly  Ser Thr Thr Cys Gln  Ala Ser Gly Asp Pro  His Tyr Thr 
    3650                 3655                 3660             


Thr Phe  Asp Gly His Arg Phe  Asp Phe Met Gly Thr  Cys Val Tyr 
    3665                 3670                 3675             


Val Leu  Ala Gln Thr Cys Gly  Thr Arg Pro Gly Leu  His Arg Phe 
    3680                 3685                 3690             


Ala Val  Leu Gln Glu Asn Val  Ala Trp Gly Asn Gly  Arg Val Ser 
    3695                 3700                 3705             


Val Thr  Arg Val Ile Thr Val  Gln Val Ala Asn Phe  Thr Leu Arg 
    3710                 3715                 3720             


Leu Glu  Gln Arg Gln Trp Lys  Val Thr Val Asn Gly  Val Asp Met 
    3725                 3730                 3735             


Lys Leu  Pro Val Val Leu Ala  Asn Gly Gln Ile Arg  Ala Ser Gln 
    3740                 3745                 3750             


His Gly  Ser Asp Val Val Ile  Glu Thr Asp Phe Gly  Leu Arg Val 
    3755                 3760                 3765             


Ala Tyr  Asp Leu Val Tyr Tyr  Val Arg Val Thr Val  Pro Gly Asn 
    3770                 3775                 3780             


Tyr Tyr  Gln Leu Met Cys Gly  Leu Cys Gly Asn Tyr  Asn Gly Asp 
    3785                 3790                 3795             


Pro Lys  Asp Asp Phe Gln Lys  Pro Asn Gly Ser Gln  Ala Gly Asn 
    3800                 3805                 3810             


Ala Asn  Glu Phe Gly Asn Ser  Trp Glu Glu Val Val  Pro Asp Ser 
    3815                 3820                 3825             


Pro Cys  Leu Pro Pro Pro Thr  Cys Pro Pro Gly Ser  Ala Gly Cys 
    3830                 3835                 3840             


Ile Pro  Ser Asp Lys Cys Pro  Pro Glu Leu Glu Lys  Lys Tyr Gln 
    3845                 3850                 3855             


Lys Glu  Glu Phe Cys Gly Leu  Leu Ser Ser Pro Thr  Gly Pro Leu 
    3860                 3865                 3870             


Ser Ser  Cys His Lys Leu Val  Asp Pro Gln Gly Pro  Leu Lys Asp 
    3875                 3880                 3885             


Cys Ile  Phe Asp Leu Cys Leu  Gly Gly Gly Asn Leu  Ser Ile Leu 
    3890                 3895                 3900             


Cys Ser  Asn Ile His Ala Tyr  Val Ser Ala Cys Gln  Ala Ala Gly 
    3905                 3910                 3915             


Gly His  Val Glu Pro Trp Arg  Asn Glu Thr Phe Cys  Pro Met Glu 
    3920                 3925                 3930             


Cys Pro  Gln Asn Ser His Tyr  Glu Leu Cys Ala Asp  Thr Cys Ser 
    3935                 3940                 3945             


Leu Gly  Cys Ser Ala Leu Ser  Ala Pro Leu Gln Cys  Pro Asp Gly 
    3950                 3955                 3960             


Cys Ala  Glu Gly Cys Gln Cys  Asp Ser Gly Phe Leu  Tyr Asn Gly 
    3965                 3970                 3975             


Gln Ala  Cys Val Pro Ile Gln  Gln Cys Gly Cys Tyr  His Asn Gly 
    3980                 3985                 3990             


Val Tyr  Tyr Glu Pro Glu Gln  Thr Val Leu Ile Asp  Asn Cys Arg 
    3995                 4000                 4005             


Gln Gln  Cys Thr Cys His Val  Gly Lys Val Val Val  Cys Gln Glu 
    4010                 4015                 4020             


His Ser  Cys Lys Pro Gly Gln  Val Cys Gln Pro Ser  Gly Gly Ile 
    4025                 4030                 4035             


Leu Ser  Cys Val Thr Lys Asp  Pro Cys His Gly Val  Thr Cys Arg 
    4040                 4045                 4050             


Pro Gln  Glu Thr Cys Lys Glu  Gln Gly Gly Gln Gly  Val Cys Leu 
    4055                 4060                 4065             


Pro Asn  Tyr Glu Ala Thr Cys  Trp Leu Trp Gly Asp  Pro His Tyr 
    4070                 4075                 4080             


His Ser  Phe Asp Gly Arg Lys  Phe Asp Phe Gln Gly  Thr Cys Asn 
    4085                 4090                 4095             


Tyr Val  Leu Ala Thr Thr Gly  Cys Pro Gly Val Ser  Thr Gln Gly 
    4100                 4105                 4110             


Leu Thr  Pro Phe Thr Val Thr  Thr Lys Asn Gln Asn  Arg Gly Asn 
    4115                 4120                 4125             


Pro Ala  Val Ser Tyr Val Arg  Val Val Thr Val Ala  Ala Leu Gly 
    4130                 4135                 4140             


Thr Asn  Ile Ser Ile His Lys  Asp Glu Ile Gly Lys  Val Arg Val 
    4145                 4150                 4155             


Asn Gly  Val Leu Thr Ala Leu  Pro Val Ser Val Ala  Asp Gly Arg 
    4160                 4165                 4170             


Ile Ser  Val Ala Gln Gly Ala  Ser Lys Ala Leu Leu  Val Ala Asp 
    4175                 4180                 4185             


Phe Gly  Leu Gln Val Ser Tyr  Asp Trp Asn Trp Arg  Val Asp Val 
    4190                 4195                 4200             


Thr Leu  Pro Ser Ser Tyr His  Gly Ala Val Cys Gly  Leu Cys Gly 
    4205                 4210                 4215             


Asn Met  Asp Arg Asn Pro Asn  Asn Asp Gln Val Phe  Pro Asn Gly 
    4220                 4225                 4230             


Thr Leu  Ala Pro Ser Ile Pro  Ile Trp Gly Gly Ser  Trp Arg Ala 
    4235                 4240                 4245             


Pro Gly  Trp Asp Pro Leu Cys  Trp Asp Glu Cys Arg  Gly Ser Cys 
    4250                 4255                 4260             


Pro Thr  Cys Pro Glu Asp Arg  Leu Glu Gln Tyr Glu  Gly Pro Gly 
    4265                 4270                 4275             


Phe Cys  Gly Pro Leu Ser Ser  Gly Thr Gly Gly Pro  Phe Thr Thr 
    4280                 4285                 4290             


Cys His  Ala His Val Pro Pro  Glu Ser Phe Phe Lys  Gly Cys Val 
    4295                 4300                 4305             


Leu Asp  Val Cys Met Gly Gly  Gly Asp Arg Asp Ile  Leu Cys Lys 
    4310                 4315                 4320             


Ala Leu  Ala Ser Tyr Val Ala  Ala Cys Gln Ala Ala  Gly Val Val 
    4325                 4330                 4335             


Ile Glu  Asp Trp Arg Ala Gln  Val Gly Cys Glu Ile  Thr Cys Pro 
    4340                 4345                 4350             


Glu Asn  Ser His Tyr Glu Val  Cys Gly Pro Pro Cys  Pro Ala Ser 
    4355                 4360                 4365             


Cys Pro  Ser Pro Ala Pro Leu  Thr Thr Pro Ala Val  Cys Glu Gly 
    4370                 4375                 4380             


Pro Cys  Val Glu Gly Cys Gln  Cys Asp Ala Gly Phe  Val Leu Ser 
    4385                 4390                 4395             


Ala Asp  Arg Cys Val Pro Leu  Asn Asn Gly Cys Gly  Cys Trp Ala 
    4400                 4405                 4410             


Asn Gly  Thr Tyr His Glu Ala  Gly Ser Glu Phe Trp  Ala Asp Gly 
    4415                 4420                 4425             


Thr Cys  Ser Gln Trp Cys Arg  Cys Gly Pro Gly Gly  Gly Ser Leu 
    4430                 4435                 4440             


Val Cys  Thr Pro Ala Ser Cys  Gly Leu Gly Glu Val  Cys Gly Leu 
    4445                 4450                 4455             


Leu Pro  Ser Gly Gln His Gly  Cys Gln Pro Val Ser  Thr Ala Glu 
    4460                 4465                 4470             


Cys Gln  Ala Trp Gly Asp Pro  His Tyr Val Thr Leu  Asp Gly His 
    4475                 4480                 4485             


Arg Phe  Asp Phe Gln Gly Thr  Cys Glu Tyr Leu Leu  Ser Ala Pro 
    4490                 4495                 4500             


Cys His  Gly Pro Pro Leu Gly  Ala Glu Asn Phe Thr  Val Thr Val 
    4505                 4510                 4515             


Ala Asn  Glu His Arg Gly Ser  Gln Ala Val Ser Tyr  Thr Arg Ser 
    4520                 4525                 4530             


Val Thr  Leu Gln Ile Tyr Asn  His Ser Leu Thr Leu  Ser Ala Arg 
    4535                 4540                 4545             


Trp Pro  Arg Lys Leu Gln Val  Asp Gly Val Phe Val  Ala Leu Pro 
    4550                 4555                 4560             


Phe Gln  Leu Asp Ser Leu Leu  His Ala His Leu Ser  Gly Ala Asp 
    4565                 4570                 4575             


Val Val  Val Thr Thr Thr Ser  Gly Leu Ser Leu Ala  Phe Asp Gly 
    4580                 4585                 4590             


Asp Ser  Phe Val Arg Leu Arg  Val Pro Ala Ala Tyr  Ala Ala Ser 
    4595                 4600                 4605             


Leu Cys  Gly Leu Cys Gly Asn  Tyr Asn Gln Asp Pro  Ala Asp Asp 
    4610                 4615                 4620             


Leu Lys  Ala Val Gly Gly Lys  Pro Ala Gly Trp Gln  Val Gly Gly 
    4625                 4630                 4635             


Ala Gln  Gly Cys Gly Glu Cys  Val Ser Lys Pro Cys  Pro Ser Pro 
    4640                 4645                 4650             


Cys Thr  Pro Glu Gln Gln Glu  Ser Phe Gly Gly Pro  Asp Ala Cys 
    4655                 4660                 4665             


Gly Val  Ile Ser Ala Thr Asp  Gly Pro Leu Ala Pro  Cys His Gly 
    4670                 4675                 4680             


Leu Val  Pro Pro Ala Gln Tyr  Phe Gln Gly Cys Leu  Leu Asp Ala 
    4685                 4690                 4695             


Cys Gln  Val Gln Gly His Pro  Gly Gly Leu Cys Pro  Ala Val Ala 
    4700                 4705                 4710             


Thr Tyr  Val Ala Ala Cys Gln  Ala Ala Gly Ala Gln  Leu Gly Glu 
    4715                 4720                 4725             


Trp Arg  Arg Pro Asp Phe Cys  Pro Leu Gln Cys Pro  Ala His Ser 
    4730                 4735                 4740             


His Tyr  Glu Leu Cys Gly Asp  Ser Cys Pro Val Ser  Cys Pro Ser 
    4745                 4750                 4755             


Leu Ser  Ala Pro Glu Gly Cys  Glu Ser Ala Cys Arg  Glu Gly Cys 
    4760                 4765                 4770             


Val Cys  Asp Ala Gly Phe Val  Leu Ser Gly Asp Thr  Cys Val Pro 
    4775                 4780                 4785             


Val Gly  Gln Cys Gly Cys Leu  His Asp Gly Arg Tyr  Tyr Pro Leu 
    4790                 4795                 4800             


Gly Glu  Val Phe Tyr Pro Gly  Pro Glu Cys Glu Arg  Arg Cys Glu 
    4805                 4810                 4815             


Cys Gly  Pro Gly Gly His Val  Thr Cys Gln Glu Gly  Ala Ala Cys 
    4820                 4825                 4830             


Gly Pro  His Glu Glu Cys Arg  Leu Glu Asp Gly Val  Gln Ala Cys 
    4835                 4840                 4845             


His Ala  Thr Gly Cys Gly Arg  Cys Leu Ala Asn Gly  Gly Ile His 
    4850                 4855                 4860             


Tyr Ile  Thr Leu Asp Gly Arg  Val Tyr Asp Leu His  Gly Ser Cys 
    4865                 4870                 4875             


Ser Tyr  Val Leu Ala Gln Val  Cys His Pro Lys Pro  Gly Asp Glu 
    4880                 4885                 4890             


Asp Phe  Ser Ile Val Leu Glu  Lys Asn Ala Ala Gly  Asp Leu Gln 
    4895                 4900                 4905             


Arg Leu  Leu Val Thr Val Ala  Gly Gln Val Val Ser  Leu Ala Gln 
    4910                 4915                 4920             


Gly Gln  Gln Val Thr Val Asp  Gly Glu Ala Val Ala  Leu Pro Val 
    4925                 4930                 4935             


Ala Val  Gly Arg Val Arg Val  Thr Ala Glu Gly Arg  Asn Met Val 
    4940                 4945                 4950             


Leu Gln  Thr Thr Lys Gly Leu  Arg Leu Leu Phe Asp  Gly Asp Ala 
    4955                 4960                 4965             


His Leu  Leu Met Ser Ile Pro  Ser Pro Phe Arg Gly  Arg Leu Cys 
    4970                 4975                 4980             


Gly Leu  Cys Gly Asn Phe Asn  Gly Asn Trp Ser Asp  Asp Phe Val 
    4985                 4990                 4995             


Leu Pro  Asn Gly Ser Ala Ala  Ser Ser Val Glu Thr  Phe Gly Ala 
    5000                 5005                 5010             


Ala Trp  Arg Ala Pro Gly Ser  Ser Lys Gly Cys Gly  Glu Gly Cys 
    5015                 5020                 5025             


Gly Pro  Gln Gly Cys Pro Val  Cys Leu Ala Glu Glu  Thr Ala Pro 
    5030                 5035                 5040             


Tyr Glu  Ser Asn Glu Ala Cys  Gly Gln Leu Arg Asn  Pro Gln Gly 
    5045                 5050                 5055             


Pro Phe  Ala Thr Cys Gln Ala  Val Leu Ser Pro Ser  Glu Tyr Phe 
    5060                 5065                 5070             


Arg Gln  Cys Val Tyr Asp Leu  Cys Ala Gln Lys Gly  Asp Lys Ala 
    5075                 5080                 5085             


Phe Leu  Cys Arg Ser Leu Ala  Ala Tyr Thr Ala Ala  Cys Gln Ala 
    5090                 5095                 5100             


Ala Gly  Val Ala Val Lys Pro  Trp Arg Thr Asp Ser  Phe Cys Pro 
    5105                 5110                 5115             


Leu His  Cys Pro Ala His Ser  His Tyr Ser Ile Cys  Thr Arg Thr 
    5120                 5125                 5130             


Cys Gln  Gly Ser Cys Ala Ala  Leu Ser Gly Leu Thr  Gly Cys Thr 
    5135                 5140                 5145             


Thr Arg  Cys Phe Glu Gly Cys  Glu Cys Asp Asp Arg  Phe Leu Leu 
    5150                 5155                 5160             


Ser Gln  Gly Val Cys Ile Pro  Val Gln Asp Cys Gly  Cys Thr His 
    5165                 5170                 5175             


Asn Gly  Arg Tyr Leu Pro Val  Asn Ser Ser Leu Leu  Thr Ser Asp 
    5180                 5185                 5190             


Cys Ser  Glu Arg Cys Ser Cys  Ser Ser Ser Ser Gly  Leu Thr Cys 
    5195                 5200                 5205             


Gln Ala  Ala Gly Cys Pro Pro  Gly Arg Val Cys Glu  Val Lys Ala 
    5210                 5215                 5220             


Glu Ala  Arg Asn Cys Trp Ala  Thr Arg Gly Leu Cys  Val Leu Ser 
    5225                 5230                 5235             


Val Gly  Ala Asn Leu Thr Thr  Phe Asp Gly Ala Arg  Gly Ala Thr 
    5240                 5245                 5250             


Thr Ser  Pro Gly Val Tyr Glu  Leu Ser Ser Arg Cys  Pro Gly Leu 
    5255                 5260                 5265             


Gln Asn  Thr Ile Pro Trp Tyr  Arg Val Val Ala Glu  Val Gln Ile 
    5270                 5275                 5280             


Cys His  Gly Lys Thr Glu Ala  Val Gly Gln Val His  Ile Phe Phe 
    5285                 5290                 5295             


Gln Asp  Gly Met Val Thr Leu  Thr Pro Asn Lys Gly  Val Trp Val 
    5300                 5305                 5310             


Asn Gly  Leu Arg Val Asp Leu  Pro Ala Glu Lys Leu  Ala Ser Val 
    5315                 5320                 5325             


Ser Val  Ser Arg Thr Pro Asp  Gly Ser Leu Leu Val  Arg Gln Lys 
    5330                 5335                 5340             


Ala Gly  Val Gln Val Trp Leu  Gly Ala Asn Gly Lys  Val Ala Val 
    5345                 5350                 5355             


Ile Val  Ser Asn Asp His Ala  Gly Lys Leu Cys Gly  Ala Cys Gly 
    5360                 5365                 5370             


Asn Phe  Asp Gly Asp Gln Thr  Asn Asp Trp His Asp  Ser Gln Glu 
    5375                 5380                 5385             


Lys Pro  Ala Met Glu Lys Trp  Arg Ala Gln Asp Phe  Ser Pro Cys 
    5390                 5395                 5400             


Tyr Gly  
    5405 


<210>  57
<211>  1278
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Gln Ser Lys Arg His Val Tyr Ser Arg Thr Pro Ser Gly Ser 
1               5                   10                  15      


Arg Met Ser Ala Glu Ala Ser Ala Arg Pro Leu Arg Val Gly Ser Arg 
            20                  25                  30          


Val Glu Val Ile Gly Lys Gly His Arg Gly Thr Val Ala Tyr Val Gly 
        35                  40                  45              


Ala Thr Leu Phe Ala Thr Gly Lys Trp Val Gly Val Ile Leu Asp Glu 
    50                  55                  60                  


Ala Lys Gly Lys Asn Asp Gly Thr Val Gln Gly Arg Lys Tyr Phe Thr 
65                  70                  75                  80  


Cys Asp Glu Gly His Gly Ile Phe Val Arg Gln Ser Gln Ile Gln Val 
                85                  90                  95      


Phe Glu Asp Gly Ala Asp Thr Thr Ser Pro Glu Thr Pro Asp Ser Ser 
            100                 105                 110         


Ala Ser Lys Val Leu Lys Arg Glu Gly Thr Asp Thr Thr Ala Lys Thr 
        115                 120                 125             


Ser Lys Leu Arg Gly Leu Lys Pro Lys Lys Ala Pro Thr Ala Arg Lys 
    130                 135                 140                 


Thr Thr Thr Arg Arg Pro Lys Pro Thr Arg Pro Ala Ser Thr Gly Val 
145                 150                 155                 160 


Ala Gly Ala Ser Ser Ser Leu Gly Pro Ser Gly Ser Ala Ser Ala Gly 
                165                 170                 175     


Glu Leu Ser Ser Ser Glu Pro Ser Thr Pro Ala Gln Thr Pro Leu Ala 
            180                 185                 190         


Ala Pro Ile Ile Pro Thr Pro Val Leu Thr Ser Pro Gly Ala Val Pro 
        195                 200                 205             


Pro Leu Pro Ser Pro Ser Lys Glu Glu Glu Gly Leu Arg Ala Gln Val 
    210                 215                 220                 


Arg Asp Leu Glu Glu Lys Leu Glu Thr Leu Arg Leu Lys Arg Ala Glu 
225                 230                 235                 240 


Asp Lys Ala Lys Leu Lys Glu Leu Glu Lys His Lys Ile Gln Leu Glu 
                245                 250                 255     


Gln Val Gln Glu Trp Lys Ser Lys Met Gln Glu Gln Gln Ala Asp Leu 
            260                 265                 270         


Gln Arg Arg Leu Lys Glu Ala Arg Lys Glu Ala Lys Glu Ala Leu Glu 
        275                 280                 285             


Ala Lys Glu Arg Tyr Met Glu Glu Met Ala Asp Thr Ala Asp Ala Ile 
    290                 295                 300                 


Glu Met Ala Thr Leu Asp Lys Glu Met Ala Glu Glu Arg Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Gln Glu Val Glu Ala Leu Lys Glu Arg Val Asp Glu Leu Thr 
                325                 330                 335     


Thr Asp Leu Glu Ile Leu Lys Ala Glu Ile Glu Glu Lys Gly Ser Asp 
            340                 345                 350         


Gly Ala Ala Ser Ser Tyr Gln Leu Lys Gln Leu Glu Glu Gln Asn Ala 
        355                 360                 365             


Arg Leu Lys Asp Ala Leu Val Arg Met Arg Asp Leu Ser Ser Ser Glu 
    370                 375                 380                 


Lys Gln Glu His Val Lys Leu Gln Lys Leu Met Glu Lys Lys Asn Gln 
385                 390                 395                 400 


Glu Leu Glu Val Val Arg Gln Gln Arg Glu Arg Leu Gln Glu Glu Leu 
                405                 410                 415     


Ser Gln Ala Glu Ser Thr Ile Asp Glu Leu Lys Glu Gln Val Asp Ala 
            420                 425                 430         


Ala Leu Gly Ala Glu Glu Met Val Glu Met Leu Thr Asp Arg Asn Leu 
        435                 440                 445             


Asn Leu Glu Glu Lys Val Arg Glu Leu Arg Glu Thr Val Gly Asp Leu 
    450                 455                 460                 


Glu Ala Met Asn Glu Met Asn Asp Glu Leu Gln Glu Asn Ala Arg Glu 
465                 470                 475                 480 


Thr Glu Leu Glu Leu Arg Glu Gln Leu Asp Met Ala Gly Ala Arg Val 
                485                 490                 495     


Arg Glu Ala Gln Lys Arg Val Glu Ala Ala Gln Glu Thr Val Ala Asp 
            500                 505                 510         


Tyr Gln Gln Thr Ile Lys Lys Tyr Arg Gln Leu Thr Ala His Leu Gln 
        515                 520                 525             


Asp Val Asn Arg Glu Leu Thr Asn Gln Gln Glu Ala Ser Val Glu Arg 
    530                 535                 540                 


Gln Gln Gln Pro Pro Pro Glu Thr Phe Asp Phe Lys Ile Lys Phe Ala 
545                 550                 555                 560 


Glu Thr Lys Ala His Ala Lys Ala Ile Glu Met Glu Leu Arg Gln Met 
                565                 570                 575     


Glu Val Ala Gln Ala Asn Arg His Met Ser Leu Leu Thr Ala Phe Met 
            580                 585                 590         


Pro Asp Ser Phe Leu Arg Pro Gly Gly Asp His Asp Cys Val Leu Val 
        595                 600                 605             


Leu Leu Leu Met Pro Arg Leu Ile Cys Lys Ala Glu Leu Ile Arg Lys 
    610                 615                 620                 


Gln Ala Gln Glu Lys Phe Glu Leu Ser Glu Asn Cys Ser Glu Arg Pro 
625                 630                 635                 640 


Gly Leu Arg Gly Ala Ala Gly Glu Gln Leu Ser Phe Ala Ala Gly Leu 
                645                 650                 655     


Val Tyr Ser Leu Ser Leu Leu Gln Ala Thr Leu His Arg Tyr Glu His 
            660                 665                 670         


Ala Leu Ser Gln Cys Ser Val Asp Val Tyr Lys Lys Val Gly Ser Leu 
        675                 680                 685             


Tyr Pro Glu Met Ser Ala His Glu Arg Ser Leu Asp Phe Leu Ile Glu 
    690                 695                 700                 


Leu Leu His Lys Asp Gln Leu Asp Glu Thr Val Asn Val Glu Pro Leu 
705                 710                 715                 720 


Thr Lys Ala Ile Lys Tyr Tyr Gln His Leu Tyr Ser Ile His Leu Ala 
                725                 730                 735     


Glu Gln Pro Glu Asp Cys Thr Met Gln Leu Ala Asp His Ile Lys Phe 
            740                 745                 750         


Thr Gln Ser Ala Leu Asp Cys Met Ser Val Glu Val Gly Arg Leu Arg 
        755                 760                 765             


Ala Phe Leu Gln Gly Gly Gln Glu Ala Thr Asp Ile Ala Leu Leu Leu 
    770                 775                 780                 


Arg Asp Leu Glu Thr Ser Cys Ser Asp Ile Arg Gln Phe Cys Lys Lys 
785                 790                 795                 800 


Ile Arg Arg Arg Met Pro Gly Thr Asp Ala Pro Gly Ile Pro Ala Ala 
                805                 810                 815     


Leu Ala Phe Gly Pro Gln Val Ser Asp Thr Leu Leu Asp Cys Arg Lys 
            820                 825                 830         


His Leu Thr Trp Val Val Ala Val Leu Gln Glu Val Ala Ala Ala Ala 
        835                 840                 845             


Ala Gln Leu Ile Ala Pro Leu Ala Glu Asn Glu Gly Leu Leu Val Ala 
    850                 855                 860                 


Ala Leu Glu Glu Leu Ala Phe Lys Ala Ser Glu Gln Ile Tyr Gly Thr 
865                 870                 875                 880 


Pro Ser Ser Ser Pro Tyr Glu Cys Leu Arg Gln Ser Cys Asn Ile Leu 
                885                 890                 895     


Ile Ser Thr Met Asn Lys Leu Ala Thr Ala Met Gln Glu Gly Glu Tyr 
            900                 905                 910         


Asp Ala Glu Arg Pro Pro Ser Lys Pro Pro Pro Val Glu Leu Arg Ala 
        915                 920                 925             


Ala Ala Leu Arg Ala Glu Ile Thr Asp Ala Glu Gly Leu Gly Leu Lys 
    930                 935                 940                 


Leu Glu Asp Arg Glu Thr Val Ile Lys Glu Leu Lys Lys Ser Leu Lys 
945                 950                 955                 960 


Ile Lys Gly Glu Glu Leu Ser Glu Ala Asn Val Arg Leu Ser Leu Leu 
                965                 970                 975     


Glu Lys Lys Leu Asp Ser Ala Ala Lys Asp Ala Asp Glu Arg Ile Glu 
            980                 985                 990         


Lys Val Gln Thr Arg Leu Glu Glu  Thr Gln Ala Leu Leu  Arg Lys Lys 
        995                 1000                 1005             


Glu Lys  Glu Phe Glu Glu Thr  Met Asp Ala Leu Gln  Ala Asp Ile 
    1010                 1015                 1020             


Asp Gln  Leu Glu Ala Glu Lys  Ala Glu Leu Lys Gln  Arg Leu Asn 
    1025                 1030                 1035             


Ser Gln  Ser Lys Arg Thr Ile  Glu Gly Leu Arg Gly  Pro Pro Pro 
    1040                 1045                 1050             


Ser Gly  Ile Ala Thr Leu Val  Ser Gly Ile Ala Gly  Glu Glu Gln 
    1055                 1060                 1065             


Gln Arg  Gly Ala Ile Pro Gly  Gln Ala Pro Gly Ser  Val Pro Gly 
    1070                 1075                 1080             


Pro Gly  Leu Val Lys Asp Ser  Pro Leu Leu Leu Gln  Gln Ile Ser 
    1085                 1090                 1095             


Ala Met  Arg Leu His Ile Ser  Gln Leu Gln His Glu  Asn Ser Ile 
    1100                 1105                 1110             


Leu Lys  Gly Ala Gln Met Lys  Ala Ser Leu Ala Ser  Leu Pro Pro 
    1115                 1120                 1125             


Leu His  Val Ala Lys Leu Ser  His Glu Gly Pro Gly  Ser Glu Leu 
    1130                 1135                 1140             


Pro Ala  Gly Ala Leu Tyr Arg  Lys Thr Ser Gln Leu  Leu Glu Thr 
    1145                 1150                 1155             


Leu Asn  Gln Leu Ser Thr His  Thr His Val Val Asp  Ile Thr Arg 
    1160                 1165                 1170             


Thr Ser  Pro Ala Ala Lys Ser  Pro Ser Ala Gln Leu  Met Glu Gln 
    1175                 1180                 1185             


Val Ala  Gln Leu Lys Ser Leu  Ser Asp Thr Val Glu  Lys Leu Lys 
    1190                 1195                 1200             


Asp Glu  Val Leu Lys Glu Thr  Val Ser Gln Arg Pro  Gly Ala Thr 
    1205                 1210                 1215             


Val Pro  Thr Asp Phe Ala Thr  Phe Pro Ser Ser Ala  Phe Leu Arg 
    1220                 1225                 1230             


Ala Lys  Glu Glu Gln Gln Asp  Asp Thr Val Tyr Met  Gly Lys Val 
    1235                 1240                 1245             


Thr Phe  Ser Cys Ala Ala Gly  Phe Gly Gln Arg His  Arg Leu Val 
    1250                 1255                 1260             


Leu Thr  Gln Glu Gln Leu His  Gln Leu His Ser Arg  Leu Ile Ser 
    1265                 1270                 1275             


<210>  58
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Ser Gly Val Ala Val Ser Asp Gly Val Ile Lys Val Phe Asn 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Ser Ser Thr Pro Glu Glu Val Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Leu Phe Cys Leu Ser Glu Asp Lys Lys Asn Ile Ile 
        35                  40                  45              


Leu Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Gln Thr Val 
    50                  55                  60                  


Asp Asp Pro Tyr Ala Thr Phe Val Lys Met Leu Pro Asp Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Thr Tyr Glu Thr Lys Glu Ser Lys Lys 
                85                  90                  95      


Glu Asp Leu Val Phe Ile Phe Trp Ala Pro Glu Ser Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Leu 
        115                 120                 125             


Thr Gly Ile Lys His Glu Leu Gln Ala Asn Cys Tyr Glu Glu Val Lys 
    130                 135                 140                 


Asp Arg Cys Thr Leu Ala Glu Lys Leu Gly Gly Ser Ala Val Ile Ser 
145                 150                 155                 160 


Leu Glu Gly Lys Pro Leu 
                165     


<210>  59
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Gly Ser Gln Ser Ser Lys Ala Pro Arg Gly Asp Val Thr Ala Glu 
1               5                   10                  15      


Glu Ala Ala Gly Ala Ser Pro Ala Lys Ala Asn Gly Gln Glu Asn Gly 
            20                  25                  30          


His Val Lys Ser Asn Gly Asp Leu Ser Pro Lys Gly Glu Gly Glu Ser 
        35                  40                  45              


Pro Pro Val Asn Gly Thr Asp Glu Ala Ala Gly Ala Thr Gly Asp Ala 
    50                  55                  60                  


Ile Glu Pro Ala Pro Pro Ser Gln Gly Ala Glu Ala Lys Gly Glu Val 
65                  70                  75                  80  


Pro Pro Lys Glu Thr Pro Lys Lys Lys Lys Lys Phe Ser Phe Lys Lys 
                85                  90                  95      


Pro Phe Lys Leu Ser Gly Leu Ser Phe Lys Arg Asn Arg Lys Glu Gly 
            100                 105                 110         


Gly Gly Asp Ser Ser Ala Ser Ser Pro Thr Glu Glu Glu Gln Glu Gln 
        115                 120                 125             


Gly Glu Ile Gly Ala Cys Ser Asp Glu Gly Thr Ala Gln Glu Gly Lys 
    130                 135                 140                 


Ala Ala Ala Thr Pro Glu Ser Gln Glu Pro Gln Ala Lys Gly Ala Glu 
145                 150                 155                 160 


Ala Ser Ala Ala Ser Glu Glu Glu Ala Gly Pro Gln Ala Thr Glu Pro 
                165                 170                 175     


Ser Thr Pro Ser Gly Pro Glu Ser Gly Pro Thr Pro Ala Ser Ala Glu 
            180                 185                 190         


Gln Asn Glu 
        195 


