                         SEQUENCE LISTING

<110>  greenovation Biotech GmbH
 
<120>  Glycosylated lysosomal proteins, method of production and uses

<130>  r68744

<150>  EP15159443.9
<151>  2015-03-17

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  vacuolar signal

<400>  1

Val Asp Thr Met 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention signal peptide

<400>  2

Lys Asp Glu Leu 
1               


<210>  3
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Asp Asn Gly Leu Ala Arg Thr Pro Thr Met Gly Trp Leu His Trp 
1               5                   10                  15      


Glu Arg Phe Met Cys Asn Leu Asp Cys Gln Glu Glu Pro Asp Ser Cys 
            20                  25                  30          


Ile Ser Glu Lys Leu Phe Met Glu Met Ala Glu Leu Met Val Ser Glu 
        35                  40                  45              


Gly Trp Lys Asp Ala Gly Tyr Glu Tyr Leu Cys Ile Asp Asp Cys Trp 
    50                  55                  60                  


Met Ala Pro Gln Arg Asp Ser Glu Gly Arg Leu Gln Ala Asp Pro Gln 
65                  70                  75                  80  


Arg Phe Pro His Gly Ile Arg Gln Leu Ala Asn Tyr Val His Ser Lys 
                85                  90                  95      


Gly Leu Lys Leu Gly Ile Tyr Ala Asp Val Gly Asn Lys Thr Cys Ala 
            100                 105                 110         


Gly Phe Pro Gly Ser Phe Gly Tyr Tyr Asp Ile Asp Ala Gln Thr Phe 
        115                 120                 125             


Ala Asp Trp Gly Val Asp Leu Leu Lys Phe Asp Gly Cys Tyr Cys Asp 
    130                 135                 140                 


Ser Leu Glu Asn Leu Ala Asp Gly Tyr Lys His Met Ser Leu Ala Leu 
145                 150                 155                 160 


Asn Arg Thr Gly Arg Ser Ile Val Tyr Ser Cys Glu Trp Pro Leu Tyr 
                165                 170                 175     


Met Trp Pro Phe Gln Lys Pro Asn Tyr Thr Glu Ile Arg Gln Tyr Cys 
            180                 185                 190         


Asn His Trp Arg Asn Phe Ala Asp Ile Asp Asp Ser Trp Lys Ser Ile 
        195                 200                 205             


Lys Ser Ile Leu Asp Trp Thr Ser Phe Asn Gln Glu Arg Ile Val Asp 
    210                 215                 220                 


Val Ala Gly Pro Gly Gly Trp Asn Asp Pro Asp Met Leu Val Ile Gly 
225                 230                 235                 240 


Asn Phe Gly Leu Ser Trp Asn Gln Gln Val Thr Gln Met Ala Leu Trp 
                245                 250                 255     


Ala Ile Met Ala Ala Pro Leu Phe Met Ser Asn Asp Leu Arg His Ile 
            260                 265                 270         


Ser Pro Gln Ala Lys Ala Leu Leu Gln Asp Lys Asp Val Ile Ala Ile 
        275                 280                 285             


Asn Gln Asp Pro Leu Gly Lys Gln Gly Tyr Gln Leu Arg Gln Gly Asp 
    290                 295                 300                 


Asn Phe Glu Val Trp Glu Arg Pro Leu Ser Gly Leu Ala Trp Ala Val 
305                 310                 315                 320 


Ala Met Ile Asn Arg Gln Glu Ile Gly Gly Pro Arg Ser Tyr Thr Ile 
                325                 330                 335     


Ala Val Ala Ser Leu Gly Lys Gly Val Ala Cys Asn Pro Ala Cys Phe 
            340                 345                 350         


Ile Thr Gln Leu Leu Pro Val Lys Arg Lys Leu Gly Phe Tyr Glu Trp 
        355                 360                 365             


Thr Ser Arg Leu Arg Ser His Ile Asn Pro Thr Gly Thr Val Leu Leu 
    370                 375                 380                 


Gln Leu Glu Asn Thr Met Gln Met Ser Leu Lys Asp Leu Leu 
385                 390                 395             


<210>  4
<211>  1197
<212>  DNA
<213>  Homo sapiens

<400>  4
ttggataatg gattggctag aactcctact atgggatggt tgcattggga gagattcatg       60

tgcaacttgg actgccaaga ggaacctgat tcttgcatct ctgagaagct gttcatggaa      120

atggctgagt tgatggtgtc tgagggatgg aaggatgctg gatacgagta cttgtgcatt      180

gatgattgct ggatggctcc tcagagagat tctgagggaa gattgcaggc tgatcctcag      240

agattccctc atggaattag gcagttggct aactacgtgc actctaaggg attgaagttg      300

ggcatctacg ctgatgtggg aaacaagact tgcgctggat tccctggatc tttcggctac      360

tacgatattg acgctcagac tttcgctgat tggggagtgg atttgttgaa gttcgatgga      420

tgctactgcg acagcttgga gaatttggct gatggataca agcacatgag cttggctttg      480

aataggactg gacggtctat tgtgtactct tgcgagtggc ctctgtacat gtggcctttc      540

cagaagccta actacactga gattaggcag tactgcaacc actggcgaaa cttcgctgat      600

atcgatgact cttggaagtc catcaagtct atcctggatt ggaccagctt caatcaagag      660

cgaattgtgg atgtggctgg acctggtgga tggaatgatc ctgatatgtt ggtgatcgga      720

aacttcggac tgtcttggaa tcagcaagtg actcagatgg ctctgtgggc tattatggct      780

gctcctttgt tcatgagcaa cgatttgagg catattagcc ctcaggctaa ggctttgttg      840

caggataagg atgtgatcgc tatcaaccag gatcctttgg gaaagcaggg ataccagttg      900

agacagggtg ataatttcga ggtgtgggag aggcctttgt ctggattggc ttgggctgtg      960

gctatgatta acagacaaga gattggaggc cctcggagct atacaattgc tgtggcttct     1020

ttgggaaagg gtgtggcttg caatcctgct tgcttcatta ctcagttgtt gcccgtgaag     1080

aggaagttgg gattctacga gtggacttct aggttgcggt cacacattaa ccctactgga     1140

actgtgttgc tgcagttgga gaacactatg cagatgagct tgaaggatct gctgtga        1197


<210>  5
<211>  26
<212>  PRT
<213>  Physcomitrella patens

<400>  5

Met Ala Phe Tyr Lys Ile Ser Ser Val Phe Phe Ile Phe Cys Phe Phe 
1               5                   10                  15      


Leu Ile Ala Leu Pro Phe His Ser Tyr Ala 
            20                  25      


<210>  6
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Arg Pro Cys Ile Pro Lys Ser Phe Gly Tyr Ser Ser Val Val Cys 
1               5                   10                  15      


Val Cys Asn Ala Thr Tyr Cys Asp Ser Phe Asp Pro Pro Thr Phe Pro 
            20                  25                  30          


Ala Leu Gly Thr Phe Ser Arg Tyr Glu Ser Thr Arg Ser Gly Arg Arg 
        35                  40                  45              


Met Glu Leu Ser Met Gly Pro Ile Gln Ala Asn His Thr Gly Thr Gly 
    50                  55                  60                  


Leu Leu Leu Thr Leu Gln Pro Glu Gln Lys Phe Gln Lys Val Lys Gly 
65                  70                  75                  80  


Phe Gly Gly Ala Met Thr Asp Ala Ala Ala Leu Asn Ile Leu Ala Leu 
                85                  90                  95      


Ser Pro Pro Ala Gln Asn Leu Leu Leu Lys Ser Tyr Phe Ser Glu Glu 
            100                 105                 110         


Gly Ile Gly Tyr Asn Ile Ile Arg Val Pro Met Ala Ser Cys Asp Phe 
        115                 120                 125             


Ser Ile Arg Thr Tyr Thr Tyr Ala Asp Thr Pro Asp Asp Phe Gln Leu 
    130                 135                 140                 


His Asn Phe Ser Leu Pro Glu Glu Asp Thr Lys Leu Lys Ile Pro Leu 
145                 150                 155                 160 


Ile His Arg Ala Leu Gln Leu Ala Gln Arg Pro Val Ser Leu Leu Ala 
                165                 170                 175     


Ser Pro Trp Thr Ser Pro Thr Trp Leu Lys Thr Asn Gly Ala Val Asn 
            180                 185                 190         


Gly Lys Gly Ser Leu Lys Gly Gln Pro Gly Asp Ile Tyr His Gln Thr 
        195                 200                 205             


Trp Ala Arg Tyr Phe Val Lys Phe Leu Asp Ala Tyr Ala Glu His Lys 
    210                 215                 220                 


Leu Gln Phe Trp Ala Val Thr Ala Glu Asn Glu Pro Ser Ala Gly Leu 
225                 230                 235                 240 


Leu Ser Gly Tyr Pro Phe Gln Cys Leu Gly Phe Thr Pro Glu His Gln 
                245                 250                 255     


Arg Asp Phe Ile Ala Arg Asp Leu Gly Pro Thr Leu Ala Asn Ser Thr 
            260                 265                 270         


His His Asn Val Arg Leu Leu Met Leu Asp Asp Gln Arg Leu Leu Leu 
        275                 280                 285             


Pro His Trp Ala Lys Val Val Leu Thr Asp Pro Glu Ala Ala Lys Tyr 
    290                 295                 300                 


Val His Gly Ile Ala Val His Trp Tyr Leu Asp Phe Leu Ala Pro Ala 
305                 310                 315                 320 


Lys Ala Thr Leu Gly Glu Thr His Arg Leu Phe Pro Asn Thr Met Leu 
                325                 330                 335     


Phe Ala Ser Glu Ala Cys Val Gly Ser Lys Phe Trp Glu Gln Ser Val 
            340                 345                 350         


Arg Leu Gly Ser Trp Asp Arg Gly Met Gln Tyr Ser His Ser Ile Ile 
        355                 360                 365             


Thr Asn Leu Leu Tyr His Val Val Gly Trp Thr Asp Trp Asn Leu Ala 
    370                 375                 380                 


Leu Asn Pro Glu Gly Gly Pro Asn Trp Val Arg Asn Phe Val Asp Ser 
385                 390                 395                 400 


Pro Ile Ile Val Asp Ile Thr Lys Asp Thr Phe Tyr Lys Gln Pro Met 
                405                 410                 415     


Phe Tyr His Leu Gly His Phe Ser Lys Phe Ile Pro Glu Gly Ser Gln 
            420                 425                 430         


Arg Val Gly Leu Val Ala Ser Gln Lys Asn Asp Leu Asp Ala Val Ala 
        435                 440                 445             


Leu Met His Pro Asp Gly Ser Ala Val Val Val Val Leu Asn Arg Ser 
    450                 455                 460                 


Ser Lys Asp Val Pro Leu Thr Ile Lys Asp Pro Ala Val Gly Phe Leu 
465                 470                 475                 480 


Glu Thr Ile Ser Pro Gly Tyr Ser Ile His Thr Tyr Leu Trp Arg Arg 
                485                 490                 495     


Gln 
    


<210>  7
<211>  1494
<212>  DNA
<213>  Homo sapiens

<400>  7
gcccgcccct gcatccctaa gagcttcggc tacagctcgg tggtgtgtgt ctgcaatgcc       60

acatactgtg actcctttga ccccccgacc tttcctgccc ttggtacctt cagccgctat      120

gagagtacac gcagtgggcg acggatggag ctgagtatgg ggcccatcca ggctaatcac      180

acgggcacag gcctgctact gaccctgcag ccagaacaga agttccagaa agtgaaggga      240

tttggagggg ccatgacaga tgctgctgct ctcaacatcc ttgccctgtc accccctgcc      300

caaaatttgc tacttaaatc gtacttctct gaagaaggaa tcggatataa catcatccgg      360

gtacccatgg ccagctgtga cttctccatc cgcacctaca cctatgcaga cacccctgat      420

gatttccagt tgcacaactt cagcctccca gaggaagata ccaagctcaa gatacccctg      480

attcaccgag ccctgcagtt ggcccagcgt cccgtttcac tccttgccag cccctggaca      540

tcacccactt ggctcaagac caatggagcg gtgaatggga aggggtcact caagggacag      600

cccggagaca tctaccacca gacctgggcc agatactttg tgaagttcct ggatgcctat      660

gctgagcaca agttacagtt ctgggcagtg acagctgaaa atgagccttc tgctgggctg      720

ttgagtggat accccttcca gtgcctgggc ttcacccctg aacatcagcg agacttcatt      780

gcccgtgacc taggtcctac cctcgccaac agtactcacc acaatgtccg cctactcatg      840

ctggatgacc aacgcttgct gctgccccac tgggcaaagg tggtactgac agacccagaa      900

gcagctaaat atgttcatgg cattgctgta cattggtacc tggactttct ggctccagcc      960

aaagccaccc taggggagac acaccgcctg ttccccaaca ccatgctctt tgcctcagag     1020

gcctgtgtgg gctccaagtt ctgggagcag agtgtgcggc taggctcctg ggatcgaggg     1080

atgcagtaca gccacagcat catcacgaac ctcctgtacc atgtggtcgg ctggaccgac     1140

tggaaccttg ccctgaaccc cgaaggagga cccaattggg tgcgtaactt tgtcgacagt     1200

cccatcattg tagacatcac caaggacacg ttttacaaac agcccatgtt ctaccacctt     1260

ggccacttca gcaagttcat tcctgagggc tcccagagag tggggctggt tgccagtcag     1320

aagaacgacc tggacgcagt ggcactgatg catcccgatg gctctgctgt tgtggtcgtg     1380

ctaaaccgct cctctaagga tgtgcctctt accatcaagg atcctgctgt gggcttcctg     1440

gagacaatct cacctggcta ctccattcac acctacctgt ggcgtcgcca gtga           1494


<210>  8
<211>  896
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Gln Gly Ala Ser Arg Pro Gly Pro Arg Asp Ala Gln Ala His Pro 
1               5                   10                  15      


Gly Arg Pro Arg Ala Val Pro Thr Gln Cys Asp Val Pro Pro Asn Ser 
            20                  25                  30          


Arg Phe Asp Cys Ala Pro Asp Lys Ala Ile Thr Gln Glu Gln Cys Glu 
        35                  40                  45              


Ala Arg Gly Cys Cys Tyr Ile Pro Ala Lys Gln Gly Leu Gln Gly Ala 
    50                  55                  60                  


Gln Met Gly Gln Pro Trp Cys Phe Phe Pro Pro Ser Tyr Pro Ser Tyr 
65                  70                  75                  80  


Lys Leu Glu Asn Leu Ser Ser Ser Glu Met Gly Tyr Thr Ala Thr Leu 
                85                  90                  95      


Thr Arg Thr Thr Pro Thr Phe Phe Pro Lys Asp Ile Leu Thr Leu Arg 
            100                 105                 110         


Leu Asp Val Met Met Glu Thr Glu Asn Arg Leu His Phe Thr Ile Lys 
        115                 120                 125             


Asp Pro Ala Asn Arg Arg Tyr Glu Val Pro Leu Glu Thr Pro His Val 
    130                 135                 140                 


His Ser Arg Ala Pro Ser Pro Leu Tyr Ser Val Glu Phe Ser Glu Glu 
145                 150                 155                 160 


Pro Phe Gly Val Ile Val Arg Arg Gln Leu Asp Gly Arg Val Leu Leu 
                165                 170                 175     


Asn Thr Thr Val Ala Pro Leu Phe Phe Ala Asp Gln Phe Leu Gln Leu 
            180                 185                 190         


Ser Thr Ser Leu Pro Ser Gln Tyr Ile Thr Gly Leu Ala Glu His Leu 
        195                 200                 205             


Ser Pro Leu Met Leu Ser Thr Ser Trp Thr Arg Ile Thr Leu Trp Asn 
    210                 215                 220                 


Arg Asp Leu Ala Pro Thr Pro Gly Ala Asn Leu Tyr Gly Ser His Pro 
225                 230                 235                 240 


Phe Tyr Leu Ala Leu Glu Asp Gly Gly Ser Ala His Gly Val Phe Leu 
                245                 250                 255     


Leu Asn Ser Asn Ala Met Asp Val Val Leu Gln Pro Ser Pro Ala Leu 
            260                 265                 270         


Ser Trp Arg Ser Thr Gly Gly Ile Leu Asp Val Tyr Ile Phe Leu Gly 
        275                 280                 285             


Pro Glu Pro Lys Ser Val Val Gln Gln Tyr Leu Asp Val Val Gly Tyr 
    290                 295                 300                 


Pro Phe Met Pro Pro Tyr Trp Gly Leu Gly Phe His Leu Cys Arg Trp 
305                 310                 315                 320 


Gly Tyr Ser Ser Thr Ala Ile Thr Arg Gln Val Val Glu Asn Met Thr 
                325                 330                 335     


Arg Ala His Phe Pro Leu Asp Val Gln Trp Asn Asp Leu Asp Tyr Met 
            340                 345                 350         


Asp Ser Arg Arg Asp Phe Thr Phe Asn Lys Asp Gly Phe Arg Asp Phe 
        355                 360                 365             


Pro Ala Met Val Gln Glu Leu His Gln Gly Gly Arg Arg Tyr Met Met 
    370                 375                 380                 


Ile Val Asp Pro Ala Ile Ser Ser Ser Gly Pro Ala Gly Ser Tyr Arg 
385                 390                 395                 400 


Pro Tyr Asp Glu Gly Leu Arg Arg Gly Val Phe Ile Thr Asn Glu Thr 
                405                 410                 415     


Gly Gln Pro Leu Ile Gly Lys Val Trp Pro Gly Ser Thr Ala Phe Pro 
            420                 425                 430         


Asp Phe Thr Asn Pro Thr Ala Leu Ala Trp Trp Glu Asp Met Val Ala 
        435                 440                 445             


Glu Phe His Asp Gln Val Pro Phe Asp Gly Met Trp Ile Asp Met Asn 
    450                 455                 460                 


Glu Pro Ser Asn Phe Ile Arg Gly Ser Glu Asp Gly Cys Pro Asn Asn 
465                 470                 475                 480 


Glu Leu Glu Asn Pro Pro Tyr Val Pro Gly Val Val Gly Gly Thr Leu 
                485                 490                 495     


Gln Ala Ala Thr Ile Cys Ala Ser Ser His Gln Phe Leu Ser Thr His 
            500                 505                 510         


Tyr Asn Leu His Asn Leu Tyr Gly Leu Thr Glu Ala Ile Ala Ser His 
        515                 520                 525             


Arg Ala Leu Val Lys Ala Arg Gly Thr Arg Pro Phe Val Ile Ser Arg 
    530                 535                 540                 


Ser Thr Phe Ala Gly His Gly Arg Tyr Ala Gly His Trp Thr Gly Asp 
545                 550                 555                 560 


Val Trp Ser Ser Trp Glu Gln Leu Ala Ser Ser Val Pro Glu Ile Leu 
                565                 570                 575     


Gln Phe Asn Leu Leu Gly Val Pro Leu Val Gly Ala Asp Val Cys Gly 
            580                 585                 590         


Phe Leu Gly Asn Thr Ser Glu Glu Leu Cys Val Arg Trp Thr Gln Leu 
        595                 600                 605             


Gly Ala Phe Tyr Pro Phe Met Arg Asn His Asn Ser Leu Leu Ser Leu 
    610                 615                 620                 


Pro Gln Glu Pro Tyr Ser Phe Ser Glu Pro Ala Gln Gln Ala Met Arg 
625                 630                 635                 640 


Lys Ala Leu Thr Leu Arg Tyr Ala Leu Leu Pro His Leu Tyr Thr Leu 
                645                 650                 655     


Phe His Gln Ala His Val Ala Gly Glu Thr Val Ala Arg Pro Leu Phe 
            660                 665                 670         


Leu Glu Phe Pro Lys Asp Ser Ser Thr Trp Thr Val Asp His Gln Leu 
        675                 680                 685             


Leu Trp Gly Glu Ala Leu Leu Ile Thr Pro Val Leu Gln Ala Gly Lys 
    690                 695                 700                 


Ala Glu Val Thr Gly Tyr Phe Pro Leu Gly Thr Trp Tyr Asp Leu Gln 
705                 710                 715                 720 


Thr Val Pro Val Glu Ala Leu Gly Ser Leu Pro Pro Pro Pro Ala Ala 
                725                 730                 735     


Pro Arg Glu Pro Ala Ile His Ser Glu Gly Gln Trp Val Thr Leu Pro 
            740                 745                 750         


Ala Pro Leu Asp Thr Ile Asn Val His Leu Arg Ala Gly Tyr Ile Ile 
        755                 760                 765             


Pro Leu Gln Gly Pro Gly Leu Thr Thr Thr Glu Ser Arg Gln Gln Pro 
    770                 775                 780                 


Met Ala Leu Ala Val Ala Leu Thr Lys Gly Gly Glu Ala Arg Gly Glu 
785                 790                 795                 800 


Leu Phe Trp Asp Asp Gly Glu Ser Leu Glu Val Leu Glu Arg Gly Ala 
                805                 810                 815     


Tyr Thr Gln Val Ile Phe Leu Ala Arg Asn Asn Thr Ile Val Asn Glu 
            820                 825                 830         


Leu Val Arg Val Thr Ser Glu Gly Ala Gly Leu Gln Leu Gln Lys Val 
        835                 840                 845             


Thr Val Leu Gly Val Ala Thr Ala Pro Gln Gln Val Leu Ser Asn Gly 
    850                 855                 860                 


Val Pro Val Ser Asn Phe Thr Tyr Ser Pro Asp Thr Lys Val Leu Asp 
865                 870                 875                 880 


Ile Cys Val Ser Leu Leu Met Gly Glu Gln Phe Leu Val Ser Trp Cys 
                885                 890                 895     


<210>  9
<211>  2691
<212>  DNA
<213>  Homo sapiens

<400>  9
cagcagggag ccagcagacc agggccccgg gatgcccagg cacaccccgg ccgtcccaga       60

gcagtgccca cacagtgcga cgtccccccc aacagccgct tcgattgcgc ccctgacaag      120

gccatcaccc aggaacagtg cgaggcccgc ggctgttgct acatccctgc aaagcagggg      180

ctgcagggag cccagatggg gcagccctgg tgcttcttcc cacccagcta ccccagctac      240

aagctggaga acctgagctc ctctgaaatg ggctacacgg ccaccctgac ccgtaccacc      300

cccaccttct tccccaagga catcctgacc ctgcggctgg acgtgatgat ggagactgag      360

aaccgcctcc acttcacgat caaagatcca gctaacaggc gctacgaggt gcccttggag      420

accccgcatg tccacagccg ggcaccgtcc ccactctaca gcgtggagtt ctccgaggag      480

cccttcgggg tgatcgtgcg ccggcagctg gacggccgcg tgctgctgaa cacgacggtg      540

gcgcccctgt tctttgcgga ccagttcctt cagctgtcca cctcgctgcc ctcgcagtat      600

atcacaggcc tcgccgagca cctcagtccc ctgatgctca gcaccagctg gaccaggatc      660

accctgtgga accgggacct tgcgcccacg cccggtgcga acctctacgg gtctcaccct      720

ttctacctgg cgctggagga cggcgggtcg gcacacgggg tgttcctgct aaacagcaat      780

gccatggatg tggtcctgca gccgagccct gcccttagct ggaggtcgac aggtgggatc      840

ctggatgtct acatcttcct gggcccagag cccaagagcg tggtgcagca gtacctggac      900

gttgtgggat acccgttcat gccgccatac tggggcctgg gcttccacct gtgccgctgg      960

ggctactcct ccaccgctat cacccgccag gtggtggaga acatgaccag ggcccacttc     1020

cccctggacg tccagtggaa cgacctggac tacatggact cccggaggga cttcacgttc     1080

aacaaggatg gcttccggga cttcccggcc atggtgcagg agctgcacca gggcggccgg     1140

cgctacatga tgatcgtgga tcctgccatc agcagctcgg gccctgccgg gagctacagg     1200

ccctacgacg agggtctgcg gaggggggtt ttcatcacca acgagaccgg ccagccgctg     1260

attgggaagg tatggcccgg gtccactgcc ttccccgact tcaccaaccc cacagccctg     1320

gcctggtggg aggacatggt ggctgagttc catgaccagg tgcccttcga cggcatgtgg     1380

attgacatga acgagccttc caacttcatc aggggctctg aggacggctg ccccaacaat     1440

gagctggaga acccacccta cgtgcctggg gtggttgggg ggaccctcca ggcggccacc     1500

atctgtgcct ccagccacca gtttctctcc acacactaca acctgcacaa cctctacggc     1560

ctgaccgaag ccatcgcctc ccacagggcg ctggtgaagg ctcgggggac acgcccattt     1620

gtgatctccc gctcgacctt tgctggccac ggccgatacg ccggccactg gacgggggac     1680

gtgtggagct cctgggagca gctcgcctcc tccgtgccag aaatcctgca gtttaacctg     1740

ctgggggtgc ctctggtcgg ggccgacgtc tgcggcttcc tgggcaacac ctcagaggag     1800

ctgtgtgtgc gctggaccca gctgggggcc ttctacccct tcatgcggaa ccacaacagc     1860

ctgctcagtc tgccccagga gccgtacagc ttcagcgagc cggcccagca ggccatgagg     1920

aaggccctca ccctgcgcta cgcactcctc ccccacctct acacactgtt ccaccaggcc     1980

cacgtcgcgg gggagaccgt ggcccggccc ctcttcctgg agttccccaa ggactctagc     2040

acctggactg tggaccacca gctcctgtgg ggggaggccc tgctcatcac cccagtgctc     2100

caggccggga aggccgaagt gactggctac ttccccttgg gcacatggta cgacctgcag     2160

acggtgccag tagaggccct tggcagcctc ccacccccac ctgcagctcc ccgtgagcca     2220

gccatccaca gcgaggggca gtgggtgacg ctgccggccc ccctggacac catcaacgtc     2280

cacctccggg ctgggtacat catccccctg cagggccctg gcctcacaac cacagagtcc     2340

cgccagcagc ccatggccct ggctgtggcc ctgaccaagg gtggggaggc ccgaggggag     2400

ctgttctggg acgatggaga gagcctggaa gtgctggagc gaggggccta cacacaggtc     2460

atcttcctgg ccaggaataa cacaatcgtg aatgagctgg tacgtgtgac cagtgaggga     2520

gctggcctgc agctgcagaa ggtgactgtc ctgggcgtgg ccacggcgcc ccagcaggtc     2580

ctctccaacg gtgtccctgt ctccaacttc acctacagcc ccgacaccaa ggtcctggac     2640

atctgtgtct cgctgttgat gggagagcag tttctcgtca gctggtgtta g              2691


