                         SEQUENCE LISTING

<110>  BASF SE
 
<120>  Recombinant microorganism for improved production of fine chemicals

<130>  0000078356

<150>  62-134608
<151>  3-18-2015

<150>  62-134607
<151>  3-18-2015

<150>  62-134611
<151>  3-18-2015

<150>  62-134610
<151>  3-18-2015


<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  1425
<212>  DNA
<213>  E.coli

<400>  1
atgagtactg aaatcaaaac tcaggtcgtg gtacttgggg caggccccgc aggttactcc       60

gctgccttcc gttgcgctga tttaggtctg gaaaccgtaa tcgtagaacg ttacaacacc      120

cttggcggtg tttgcctgaa cgtcggctgt atcccttcta aagcactgct gcacgtagca      180

aaagttatcg aagaagccaa agcgctggct gaacacggta tcgtcttcgg cgaaccgaaa      240

accgatattg acaagattcg tacctggaaa gagaaagtga tcaatcagct gaccggtggt      300

ctggctggta tggcgaaagg ccgcaaagtc aaagtggtca acggtctggg taaatttacc      360

ggggctaaca ccctggaagt tgaaggtgag aacggtaaaa ccgtgatcaa cttcgacaac      420

gcgatcattg cagcgggttc tcgcccgatc caactgccgt ttattccgca tgaagatccg      480

cgtatctggg actccactga cgcgctggaa ctgaaagaag taccagaacg cctgctggta      540

atgggtggcg gtatcatcgg tctggaaatg ggcaccgtat accacgcgct gggttcacag      600

attgacgtgg ttgaaatgtt cgaccaggtt atcccggcag ctgacaaaga catcgttaaa      660

gtcttcacca agcgtatcag caagaaattc aacctgatgc tggaaaccaa agttaccgcc      720

gttgaagcga aagaagacgg tatttatgtg acgatggaag gcaaaaaagc acccgctgaa      780

ccgcagcgtt acgacgccgt gctggtagcg attggtcgtg tgccgaacgg taaaaacctc      840

gacgcaggca aagctggcgt ggaagtggac gaccgtggtt tcatccgcgt tgacaaacag      900

ctgcgtacca acgtaccgca catctttgct atcggcgata tcgtcggtca gccgatgctg      960

gcacacaaag gtgttcacga aggtcacgtt gccgctgaag ttatcgccgg taagaaacac     1020

tacttcgatc cgaaagttat cccgtccatc gcctataccg aaccagaagt tgcatgggta     1080

ggtctgactg agaaagaagc gaaagagaaa ggcatcagct atgaaaccgc caccttcccg     1140

tgggctgctt ctggtcgtgc tatcgcttcc gactgcgcag acggtatgac caagctgatt     1200

ttcgacaaag aatctcaccg tgtgatcggt ggtgcgattg tcggtaccaa cggcggcgag     1260

ctgctgggtg aaatcggcct ggcaatcgaa atgggttgtg atgctgaaga catcgcactg     1320

accatccacg cgcacccgac tctgcacgag tctgtgggcc tggcggcaga agtgttcgaa     1380

ggtagcatta ccgacctgcc gaacccgaaa gcgaagaaga agtaa                     1425


<210>  2
<211>  474
<212>  PRT
<213>  E.coli

<400>  2

Met Ser Thr Glu Ile Lys Thr Gln Val Val Val Leu Gly Ala Gly Pro 
1               5                   10                  15      


Ala Gly Tyr Ser Ala Ala Phe Arg Cys Ala Asp Leu Gly Leu Glu Thr 
            20                  25                  30          


Val Ile Val Glu Arg Tyr Asn Thr Leu Gly Gly Val Cys Leu Asn Val 
        35                  40                  45              


Gly Cys Ile Pro Ser Lys Ala Leu Leu His Val Ala Lys Val Ile Glu 
    50                  55                  60                  


Glu Ala Lys Ala Leu Ala Glu His Gly Ile Val Phe Gly Glu Pro Lys 
65                  70                  75                  80  


Thr Asp Ile Asp Lys Ile Arg Thr Trp Lys Glu Lys Val Ile Asn Gln 
                85                  90                  95      


Leu Thr Gly Gly Leu Ala Gly Met Ala Lys Gly Arg Lys Val Lys Val 
            100                 105                 110         


Val Asn Gly Leu Gly Lys Phe Thr Gly Ala Asn Thr Leu Glu Val Glu 
        115                 120                 125             


Gly Glu Asn Gly Lys Thr Val Ile Asn Phe Asp Asn Ala Ile Ile Ala 
    130                 135                 140                 


Ala Gly Ser Arg Pro Ile Gln Leu Pro Phe Ile Pro His Glu Asp Pro 
145                 150                 155                 160 


Arg Ile Trp Asp Ser Thr Asp Ala Leu Glu Leu Lys Glu Val Pro Glu 
                165                 170                 175     


Arg Leu Leu Val Met Gly Gly Gly Ile Ile Gly Leu Glu Met Gly Thr 
            180                 185                 190         


Val Tyr His Ala Leu Gly Ser Gln Ile Asp Val Val Glu Met Phe Asp 
        195                 200                 205             


Gln Val Ile Pro Ala Ala Asp Lys Asp Ile Val Lys Val Phe Thr Lys 
    210                 215                 220                 


Arg Ile Ser Lys Lys Phe Asn Leu Met Leu Glu Thr Lys Val Thr Ala 
225                 230                 235                 240 


Val Glu Ala Lys Glu Asp Gly Ile Tyr Val Thr Met Glu Gly Lys Lys 
                245                 250                 255     


Ala Pro Ala Glu Pro Gln Arg Tyr Asp Ala Val Leu Val Ala Ile Gly 
            260                 265                 270         


Arg Val Pro Asn Gly Lys Asn Leu Asp Ala Gly Lys Ala Gly Val Glu 
        275                 280                 285             


Val Asp Asp Arg Gly Phe Ile Arg Val Asp Lys Gln Leu Arg Thr Asn 
    290                 295                 300                 


Val Pro His Ile Phe Ala Ile Gly Asp Ile Val Gly Gln Pro Met Leu 
305                 310                 315                 320 


Ala His Lys Gly Val His Glu Gly His Val Ala Ala Glu Val Ile Ala 
                325                 330                 335     


Gly Lys Lys His Tyr Phe Asp Pro Lys Val Ile Pro Ser Ile Ala Tyr 
            340                 345                 350         


Thr Glu Pro Glu Val Ala Trp Val Gly Leu Thr Glu Lys Glu Ala Lys 
        355                 360                 365             


Glu Lys Gly Ile Ser Tyr Glu Thr Ala Thr Phe Pro Trp Ala Ala Ser 
    370                 375                 380                 


Gly Arg Ala Ile Ala Ser Asp Cys Ala Asp Gly Met Thr Lys Leu Ile 
385                 390                 395                 400 


Phe Asp Lys Glu Ser His Arg Val Ile Gly Gly Ala Ile Val Gly Thr 
                405                 410                 415     


Asn Gly Gly Glu Leu Leu Gly Glu Ile Gly Leu Ala Ile Glu Met Gly 
            420                 425                 430         


Cys Asp Ala Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr Leu 
        435                 440                 445             


His Glu Ser Val Gly Leu Ala Ala Glu Val Phe Glu Gly Ser Ile Thr 
    450                 455                 460                 


Asp Leu Pro Asn Pro Lys Ala Lys Lys Lys 
465                 470                 


<210>  3
<211>  1425
<212>  DNA
<213>  E.coli

<400>  3
atgagtactg aaatcaaaac tcaggtcgtg gtacttgggg caggccccgc aggttactcc       60

gctgccttcc gttgcgctga tttaggtctg gaaaccgtaa tcgtagaacg ttacaacacc      120

cttggcggtg tttgcctgaa cgtcggctgt atcccttcta aagcactgct gcacgtagca      180

aaagttatcg aagaagccaa agcgctgcct gaacacggta tcgtcttcgg cgaaccgaaa      240

accgatattg acaagattcg tacctggaaa gagaaagtga tcaatcagct gaccggtggt      300

ctggctggta tggcgaaagg ccgcaaagtc aaagtggtca acggtctggg taaatttacc      360

ggggctaaca ccctggaagt tgaaggtgag aacggtaaaa ccgtgatcaa cttcgacaac      420

gcgatcattg cagcgggttc tcgcccgatc caactgccgt ttattccgca tgaagatccg      480

cgtatctggg actccactga cgcgctggaa ctgaaagaag taccagaacg cctgctggta      540

atgggtggcg gtatcatcgg tctggaaatg ggcaccgtat accacgcgct gggttcacag      600

attgacgtgg ttgaaatgtt cgaccaggtt atcccggcag ctgacaaaga catcgttaaa      660

gtcttcacca agcgtatcag caagaaattc aacctgatgc tggaaaccaa agttaccgcc      720

gttgaagcga aagaagacgg tatttatgtg acgatggaag gcaaaaaagc acccgctgaa      780

ccgcagcgtt acgacgccgt gctggtagcg attggtcgtg tgccgaacgg taaaaacctc      840

gacgcaggca aagctggcgt ggaagtggac gaccgtggtt tcatccgcgt tgacaaacag      900

ctgcgtacca acgtaccgca catctttgct atcggcgata tcgtcggtca gccgatgctg      960

gcacacaaag gtgttcacga aggtcacgtt gccgctgaag ttatcgccgg taagaaacac     1020

tacttcgatc cgaaagttat cccgtccatc gcctataccg aaccagaagt tgcatgggta     1080

ggtctgactg agaaagaagc gaaagagaaa ggcatcagct atgaaaccgc caccttcccg     1140

tgggctgctt ctggtcgtgc tatcgcttcc gactgcgcag acggtatgac caagctgatt     1200

ttcgacaaag aatctcaccg tgtgatcggt ggtgcgattg tcggtaccaa cggcggcgag     1260

ctgctgggtg aaatcggcct ggcaatcgaa atgggttgtg atgctgaaga catcgcactg     1320

accatccacg cgcacccgac tctgcacgag tctgtgggcc tggcggcaga agtgttcgaa     1380

ggtagcatta ccgacctgcc gaacccgaaa gcgaagaaga agtaa                     1425


<210>  4
<211>  474
<212>  PRT
<213>  E.coli

<400>  4

Met Ser Thr Glu Ile Lys Thr Gln Val Val Val Leu Gly Ala Gly Pro 
1               5                   10                  15      


Ala Gly Tyr Ser Ala Ala Phe Arg Cys Ala Asp Leu Gly Leu Glu Thr 
            20                  25                  30          


Val Ile Val Glu Arg Tyr Asn Thr Leu Gly Gly Val Cys Leu Asn Val 
        35                  40                  45              


Gly Cys Ile Pro Ser Lys Ala Leu Leu His Val Ala Lys Val Ile Glu 
    50                  55                  60                  


Glu Ala Lys Ala Leu Pro Glu His Gly Ile Val Phe Gly Glu Pro Lys 
65                  70                  75                  80  


Thr Asp Ile Asp Lys Ile Arg Thr Trp Lys Glu Lys Val Ile Asn Gln 
                85                  90                  95      


Leu Thr Gly Gly Leu Ala Gly Met Ala Lys Gly Arg Lys Val Lys Val 
            100                 105                 110         


Val Asn Gly Leu Gly Lys Phe Thr Gly Ala Asn Thr Leu Glu Val Glu 
        115                 120                 125             


Gly Glu Asn Gly Lys Thr Val Ile Asn Phe Asp Asn Ala Ile Ile Ala 
    130                 135                 140                 


Ala Gly Ser Arg Pro Ile Gln Leu Pro Phe Ile Pro His Glu Asp Pro 
145                 150                 155                 160 


Arg Ile Trp Asp Ser Thr Asp Ala Leu Glu Leu Lys Glu Val Pro Glu 
                165                 170                 175     


Arg Leu Leu Val Met Gly Gly Gly Ile Ile Gly Leu Glu Met Gly Thr 
            180                 185                 190         


Val Tyr His Ala Leu Gly Ser Gln Ile Asp Val Val Glu Met Phe Asp 
        195                 200                 205             


Gln Val Ile Pro Ala Ala Asp Lys Asp Ile Val Lys Val Phe Thr Lys 
    210                 215                 220                 


Arg Ile Ser Lys Lys Phe Asn Leu Met Leu Glu Thr Lys Val Thr Ala 
225                 230                 235                 240 


Val Glu Ala Lys Glu Asp Gly Ile Tyr Val Thr Met Glu Gly Lys Lys 
                245                 250                 255     


Ala Pro Ala Glu Pro Gln Arg Tyr Asp Ala Val Leu Val Ala Ile Gly 
            260                 265                 270         


Arg Val Pro Asn Gly Lys Asn Leu Asp Ala Gly Lys Ala Gly Val Glu 
        275                 280                 285             


Val Asp Asp Arg Gly Phe Ile Arg Val Asp Lys Gln Leu Arg Thr Asn 
    290                 295                 300                 


Val Pro His Ile Phe Ala Ile Gly Asp Ile Val Gly Gln Pro Met Leu 
305                 310                 315                 320 


Ala His Lys Gly Val His Glu Gly His Val Ala Ala Glu Val Ile Ala 
                325                 330                 335     


Gly Lys Lys His Tyr Phe Asp Pro Lys Val Ile Pro Ser Ile Ala Tyr 
            340                 345                 350         


Thr Glu Pro Glu Val Ala Trp Val Gly Leu Thr Glu Lys Glu Ala Lys 
        355                 360                 365             


Glu Lys Gly Ile Ser Tyr Glu Thr Ala Thr Phe Pro Trp Ala Ala Ser 
    370                 375                 380                 


Gly Arg Ala Ile Ala Ser Asp Cys Ala Asp Gly Met Thr Lys Leu Ile 
385                 390                 395                 400 


Phe Asp Lys Glu Ser His Arg Val Ile Gly Gly Ala Ile Val Gly Thr 
                405                 410                 415     


Asn Gly Gly Glu Leu Leu Gly Glu Ile Gly Leu Ala Ile Glu Met Gly 
            420                 425                 430         


Cys Asp Ala Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr Leu 
        435                 440                 445             


His Glu Ser Val Gly Leu Ala Ala Glu Val Phe Glu Gly Ser Ile Thr 
    450                 455                 460                 


Asp Leu Pro Asn Pro Lys Ala Lys Lys Lys 
465                 470                 


<210>  5
<211>  2283
<212>  DNA
<213>  E.coli

<400>  5
atgtccgagc ttaatgaaaa gttagccaca gcctgggaag gttttaccaa aggtgactgg       60

cagaatgaag taaacgtccg tgacttcatt cagaaaaact acactccgta cgagggtgac      120

gagtccttcc tggctggcgc tactgaagcg accaccaccc tgtgggacaa agtaatggaa      180

ggcgttaaac tggaaaaccg cactcacgcg ccagttgact ttgacaccgc tgttgcttcc      240

accatcacct ctcacgacgc tggctacatc aacaaagcgt tggaaaaagt tgttggtcta      300

cagactgaag ctccgctgaa acgtgctctt atcccgttcg gtggtatcaa aatgatcgag      360

ggttcctgca aagcgtacaa ccgcgaactg gacccgatga tcaaaaaaat cttcactgaa      420

taccgtaaaa ctcacaacca gggcgtgttc gacgtttaca ctccggacat cctgcgttgc      480

cgtaaatccg gtgttctgac cggtctgcca gatgcttatg gccgtggccg tatcatcggt      540

gactaccgtc gcgttgcgct gtacggtatc gactacctga tgaaagacaa atacgctcag      600

ttcacctctc tgcaggctga tctggaaaac ggcgtaaacc tggaacagac tatccgtctg      660

cgcgaagaaa tcgctgaaca gcaccgcgct ctgggtcaga tgaaagaaat ggctgcgaaa      720

tacggctacg acatctctgg tccggctacc aacgctcagg aagctatcca gtggacttac      780

ttcggctacc tggctgctgt taagtctcag aacggtgctg caatgtcctt cggtcgtacc      840

tccaccttcc tggatgtgta catcgaacgt gacctgaaag ctggcaagat caccgaacaa      900

gaagcgcagg aaatggttga ccacctggtc atgaaactgc gtatggttcg cttcctgcgt      960

actccggaat acgatgaact gttctctggc gacccgatct gggcaaccga atctatcggt     1020

ggtatgggcc tcgacggtcg taccctggtt accaaaaaca gcttccgttt cctgaacacc     1080

ctgtacacca tgggtccgtc tccggaaccg aacatgacca ttctgtggtc tgaaaaactg     1140

ccgctgaact tcaagaaatt cgccgctaaa gtgtccatcg acacctcttc tctgcaatat     1200

gagaacgatg acctgatgcg tccggacttc aacaacgatg actacgctat tgcttgctgc     1260

gtaagcccga tgatcgttgg taaacaaatg cagttcttcg gtgcgcgtgc aaacctggcg     1320

aaaaccatgc tgtacgcaat caacggcggc gttgacgaaa aactgaaaat gcaggttggt     1380

ccgaagtctg aaccgatcaa aggcgatgtc ctgaactatg atgaagtgat ggagcgcatg     1440

gatcacttca tggactggct ggctaaacag tacatcactg cactgaacat catccactac     1500

atgcacgaca agtacagcta cgaagcctct ctgatggcgc tgcacgaccg tgacgttatc     1560

cgcaccatgg cgtgtggtat cgctggtctg tccgttgctg ctgactccct gtctgcaatc     1620

aaatatgcga aagttaaacc gattcgtgac gaagacggtc tggctatcga cttcgaaatc     1680

gaaggcgaat acccgcagtt tggtaacaat gatccgcgtg tagatgacct ggctgttgac     1740

ctggtagaac gtttcatgaa gaaaattcag aaactgcaca cctaccgtga cgctatcccg     1800

actcagtctg ttctgaccat cacttctaac gttgtgtatg gtaagaaaac tggtaacacc     1860

ccagacggtc gtcgtgctgg cgcgccgttc ggaccgggtg ctaacccgat gcacggtcgt     1920

gaccagaaag gtgctgtagc gtctctgact tccgttgcta aactaccgtt tgcttacgct     1980

aaagatggta tctcctacac cttctctatc gttccgaacg cactgggtaa agacgacgaa     2040

gttcgtaaga ccaacctggc tggtctgatg gatggttact tccaccacga agcatccatc     2100

gaaggtggtc agcacctgaa cgttaacgtg atgaaccgtg aaatgctgct cgacgcgatg     2160

gaaaacccgg aaaaatatcc gcagctgacc atccgtgtat ctggctacgc agtacgtttc     2220

aactcgctga ctaaagaaca gcagcaggac gttattactc gtaccttcac tcaatctatg     2280

taa                                                                   2283


<210>  6
<211>  760
<212>  PRT
<213>  E.coli

<400>  6

Met Ser Glu Leu Asn Glu Lys Leu Ala Thr Ala Trp Glu Gly Phe Thr 
1               5                   10                  15      


Lys Gly Asp Trp Gln Asn Glu Val Asn Val Arg Asp Phe Ile Gln Lys 
            20                  25                  30          


Asn Tyr Thr Pro Tyr Glu Gly Asp Glu Ser Phe Leu Ala Gly Ala Thr 
        35                  40                  45              


Glu Ala Thr Thr Thr Leu Trp Asp Lys Val Met Glu Gly Val Lys Leu 
    50                  55                  60                  


Glu Asn Arg Thr His Ala Pro Val Asp Phe Asp Thr Ala Val Ala Ser 
65                  70                  75                  80  


Thr Ile Thr Ser His Asp Ala Gly Tyr Ile Asn Lys Ala Leu Glu Lys 
                85                  90                  95      


Val Val Gly Leu Gln Thr Glu Ala Pro Leu Lys Arg Ala Leu Ile Pro 
            100                 105                 110         


Phe Gly Gly Ile Lys Met Ile Glu Gly Ser Cys Lys Ala Tyr Asn Arg 
        115                 120                 125             


Glu Leu Asp Pro Met Ile Lys Lys Ile Phe Thr Glu Tyr Arg Lys Thr 
    130                 135                 140                 


His Asn Gln Gly Val Phe Asp Val Tyr Thr Pro Asp Ile Leu Arg Cys 
145                 150                 155                 160 


Arg Lys Ser Gly Val Leu Thr Gly Leu Pro Asp Ala Tyr Gly Arg Gly 
                165                 170                 175     


Arg Ile Ile Gly Asp Tyr Arg Arg Val Ala Leu Tyr Gly Ile Asp Tyr 
            180                 185                 190         


Leu Met Lys Asp Lys Tyr Ala Gln Phe Thr Ser Leu Gln Ala Asp Leu 
        195                 200                 205             


Glu Asn Gly Val Asn Leu Glu Gln Thr Ile Arg Leu Arg Glu Glu Ile 
    210                 215                 220                 


Ala Glu Gln His Arg Ala Leu Gly Gln Met Lys Glu Met Ala Ala Lys 
225                 230                 235                 240 


Tyr Gly Tyr Asp Ile Ser Gly Pro Ala Thr Asn Ala Gln Glu Ala Ile 
                245                 250                 255     


Gln Trp Thr Tyr Phe Gly Tyr Leu Ala Ala Val Lys Ser Gln Asn Gly 
            260                 265                 270         


Ala Ala Met Ser Phe Gly Arg Thr Ser Thr Phe Leu Asp Val Tyr Ile 
        275                 280                 285             


Glu Arg Asp Leu Lys Ala Gly Lys Ile Thr Glu Gln Glu Ala Gln Glu 
    290                 295                 300                 


Met Val Asp His Leu Val Met Lys Leu Arg Met Val Arg Phe Leu Arg 
305                 310                 315                 320 


Thr Pro Glu Tyr Asp Glu Leu Phe Ser Gly Asp Pro Ile Trp Ala Thr 
                325                 330                 335     


Glu Ser Ile Gly Gly Met Gly Leu Asp Gly Arg Thr Leu Val Thr Lys 
            340                 345                 350         


Asn Ser Phe Arg Phe Leu Asn Thr Leu Tyr Thr Met Gly Pro Ser Pro 
        355                 360                 365             


Glu Pro Asn Met Thr Ile Leu Trp Ser Glu Lys Leu Pro Leu Asn Phe 
    370                 375                 380                 


Lys Lys Phe Ala Ala Lys Val Ser Ile Asp Thr Ser Ser Leu Gln Tyr 
385                 390                 395                 400 


Glu Asn Asp Asp Leu Met Arg Pro Asp Phe Asn Asn Asp Asp Tyr Ala 
                405                 410                 415     


Ile Ala Cys Cys Val Ser Pro Met Ile Val Gly Lys Gln Met Gln Phe 
            420                 425                 430         


Phe Gly Ala Arg Ala Asn Leu Ala Lys Thr Met Leu Tyr Ala Ile Asn 
        435                 440                 445             


Gly Gly Val Asp Glu Lys Leu Lys Met Gln Val Gly Pro Lys Ser Glu 
    450                 455                 460                 


Pro Ile Lys Gly Asp Val Leu Asn Tyr Asp Glu Val Met Glu Arg Met 
465                 470                 475                 480 


Asp His Phe Met Asp Trp Leu Ala Lys Gln Tyr Ile Thr Ala Leu Asn 
                485                 490                 495     


Ile Ile His Tyr Met His Asp Lys Tyr Ser Tyr Glu Ala Ser Leu Met 
            500                 505                 510         


Ala Leu His Asp Arg Asp Val Ile Arg Thr Met Ala Cys Gly Ile Ala 
        515                 520                 525             


Gly Leu Ser Val Ala Ala Asp Ser Leu Ser Ala Ile Lys Tyr Ala Lys 
    530                 535                 540                 


Val Lys Pro Ile Arg Asp Glu Asp Gly Leu Ala Ile Asp Phe Glu Ile 
545                 550                 555                 560 


Glu Gly Glu Tyr Pro Gln Phe Gly Asn Asn Asp Pro Arg Val Asp Asp 
                565                 570                 575     


Leu Ala Val Asp Leu Val Glu Arg Phe Met Lys Lys Ile Gln Lys Leu 
            580                 585                 590         


His Thr Tyr Arg Asp Ala Ile Pro Thr Gln Ser Val Leu Thr Ile Thr 
        595                 600                 605             


Ser Asn Val Val Tyr Gly Lys Lys Thr Gly Asn Thr Pro Asp Gly Arg 
    610                 615                 620                 


Arg Ala Gly Ala Pro Phe Gly Pro Gly Ala Asn Pro Met His Gly Arg 
625                 630                 635                 640 


Asp Gln Lys Gly Ala Val Ala Ser Leu Thr Ser Val Ala Lys Leu Pro 
                645                 650                 655     


Phe Ala Tyr Ala Lys Asp Gly Ile Ser Tyr Thr Phe Ser Ile Val Pro 
            660                 665                 670         


Asn Ala Leu Gly Lys Asp Asp Glu Val Arg Lys Thr Asn Leu Ala Gly 
        675                 680                 685             


Leu Met Asp Gly Tyr Phe His His Glu Ala Ser Ile Glu Gly Gly Gln 
    690                 695                 700                 


His Leu Asn Val Asn Val Met Asn Arg Glu Met Leu Leu Asp Ala Met 
705                 710                 715                 720 


Glu Asn Pro Glu Lys Tyr Pro Gln Leu Thr Ile Arg Val Ser Gly Tyr 
                725                 730                 735     


Ala Val Arg Phe Asn Ser Leu Thr Lys Glu Gln Gln Gln Asp Val Ile 
            740                 745                 750         


Thr Arg Thr Phe Thr Gln Ser Met 
        755                 760 


<210>  7
<211>  2676
<212>  DNA
<213>  E.coli

<400>  7
atggctgtta ctaatgtcgc tgaacttaac gcactcgtag agcgtgtaaa aaaagcccag       60

cgtgaatatg ccagtttcac tcaagagcaa gtagacaaaa tcttccgcgc cgccgctctg      120

gctgctgcag atgctcgaat cccactcgcg aaaatggccg ttgccgaatc cggcatgggt      180

atcgtcgaag ataaagtgat caaaaaccac tttgcttctg aatatatcta caacgcctat      240

aaagatgaaa aaacctgtgg tgttctgtct gaagacgaca cttttggtac catcactatc      300

gctgaaccaa tcggtattat ttgcggtatc gttccgacca ctaacccgac ttcaactgct      360

atcttcaaat cgctgatcag tctgaagacc cgtaacgcca ttatcttctc cccgcacccg      420

cgtgcaaaag atgccaccaa caaagcggct gatatcgttc tgcaggctgc tatcgctgcc      480

ggtgctccga aagatctgat cggctggatc gatcaacctt ctgttgaact gtctaacgca      540

ctgatgcacc acccagacat caacctgatc ctcgcgactg gtggtccggg catggttaaa      600

gccgcataca gctccggtaa accagctatc ggtgtaggcg cgggcaacac tccagttgtt      660

atcgatgaaa ctgctgatat caaacgtgca gttgcatctg tactgatgtc caaaaccttc      720

gacaacggcg taatctgtgc ttctgaacag tctgttgttg ttgttgactc tgtttatgac      780

gctgtacgtg aacgttttgc aacccacggc ggctatctgt tgcagggtaa agagctgaaa      840

gctgttcagg atgttatcct gaaaaacggt gcgctgaacg cggctatcgt tggtcagcca      900

gcctataaaa ttgctgaact ggcaggcttc tctgtaccag aaaacaccaa gattctgatc      960

ggtgaagtga ccgttgttga tgaaagcgaa ccgttcgcac atgaaaaact gtccccgact     1020

ctggcaatgt accgcgctaa agatttcgaa gacgcggtag aaaaagcaga gaaactggtt     1080

gctatgggcg gtatcggtca tacctcttgc ctgtacactg accaggataa ccaaccggct     1140

cgcgtttctt acttcggtca gaaaatgaaa acggctcgta tcctgattaa caccccagcg     1200

tctcagggtg gtatcggtga cctgtataac ttcaaactcg caccttccct gactctgggt     1260

tgtggttctt ggggtggtaa ctccatctct gaaaacgttg gtccgaaaca cctgatcaac     1320

aagaaaaccg ttgctaagcg agctgaaaac atgttgtggc acaaacttcc gaaatctatc     1380

tacttccgcc gtggctccct gccaatcgcg ctggatgaag tgattactga tggccacaaa     1440

cgtgcgctca tcgtgactga ccgcttcctg ttcaacaatg gttatgctga tcagatcact     1500

tccgtactga aagcagcagg cgttgaaact gaagtcttct tcgaagtaga agcggacccg     1560

accctgagca tcgttcgtaa aggtgcagaa ctggcaaact ccttcaaacc agacgtgatt     1620

atcgcgctgg gtggtggttc cccgatggac gccgcgaaga tcatgtgggt tatgtacgaa     1680

catccggaaa ctcacttcga agagctggcg ctgcgcttta tggatatccg taaacgtatc     1740

tacaagttcc cgaaaatggg cgtgaaagcg aaaatgatcg ctgtcaccac cacttctggt     1800

acaggttctg aagtcactcc gtttgcggtt gtaactgacg acgctactgg tcagaaatat     1860

ccgctggcag actatgcgct gactccggat atggcgattg tcgacgccaa cctggttatg     1920

gacatgccga agtccctgtg tgctttcggt ggtctggacg cagtaactca cgccatggaa     1980

gcttatgttt ctgtactggc atctgagttc tctgatggtc aggctctgca ggcactgaaa     2040

ctgctgaaag aatatctgcc agcgtcctac cacgaagggt ctaaaaatcc ggtagcgcgt     2100

gaacgtgttc acagtgcagc gactatcgcg ggtatcgcgt ttgcgaacgc cttcctgggt     2160

gtatgtcact caatggcgca caaactgggt tcccagttcc atattccgca cggtctggca     2220

aacgccctgc tgatttgtaa cgttattcgc tacaatgcga acgacaaccc gaccaagcag     2280

actgcattca gccagtatga ccgtccgcag gctcgccgtc gttatgctga aattgccgac     2340

cacttgggtc tgagcgcacc gggcgaccgt actgctgcta agatcgagaa actgctggca     2400

tggctggaaa cgctgaaagc tgaactgggt attccgaaat ctatccgtga agctggcgtt     2460

caggaagcag acttcctggc gaacgtggat aaactgtctg aagatgcgtt cgatgaccag     2520

tgcaccggcg ctaacccgcg ttacccgctg atctccgagc tgaaacagat cctgctggat     2580

acctactacg gtcgtgatta tgtagaaggt gaaactgcag cgaaaaaaga agccgctccg     2640

gctaaagctg agaaaaaagc gaaaaaatcc gcttaa                               2676


<210>  8
<211>  891
<212>  PRT
<213>  E.coli

<400>  8

Met Ala Val Thr Asn Val Ala Glu Leu Asn Ala Leu Val Glu Arg Val 
1               5                   10                  15      


Lys Lys Ala Gln Arg Glu Tyr Ala Ser Phe Thr Gln Glu Gln Val Asp 
            20                  25                  30          


Lys Ile Phe Arg Ala Ala Ala Leu Ala Ala Ala Asp Ala Arg Ile Pro 
        35                  40                  45              


Leu Ala Lys Met Ala Val Ala Glu Ser Gly Met Gly Ile Val Glu Asp 
    50                  55                  60                  


Lys Val Ile Lys Asn His Phe Ala Ser Glu Tyr Ile Tyr Asn Ala Tyr 
65                  70                  75                  80  


Lys Asp Glu Lys Thr Cys Gly Val Leu Ser Glu Asp Asp Thr Phe Gly 
                85                  90                  95      


Thr Ile Thr Ile Ala Glu Pro Ile Gly Ile Ile Cys Gly Ile Val Pro 
            100                 105                 110         


Thr Thr Asn Pro Thr Ser Thr Ala Ile Phe Lys Ser Leu Ile Ser Leu 
        115                 120                 125             


Lys Thr Arg Asn Ala Ile Ile Phe Ser Pro His Pro Arg Ala Lys Asp 
    130                 135                 140                 


Ala Thr Asn Lys Ala Ala Asp Ile Val Leu Gln Ala Ala Ile Ala Ala 
145                 150                 155                 160 


Gly Ala Pro Lys Asp Leu Ile Gly Trp Ile Asp Gln Pro Ser Val Glu 
                165                 170                 175     


Leu Ser Asn Ala Leu Met His His Pro Asp Ile Asn Leu Ile Leu Ala 
            180                 185                 190         


Thr Gly Gly Pro Gly Met Val Lys Ala Ala Tyr Ser Ser Gly Lys Pro 
        195                 200                 205             


Ala Ile Gly Val Gly Ala Gly Asn Thr Pro Val Val Ile Asp Glu Thr 
    210                 215                 220                 


Ala Asp Ile Lys Arg Ala Val Ala Ser Val Leu Met Ser Lys Thr Phe 
225                 230                 235                 240 


Asp Asn Gly Val Ile Cys Ala Ser Glu Gln Ser Val Val Val Val Asp 
                245                 250                 255     


Ser Val Tyr Asp Ala Val Arg Glu Arg Phe Ala Thr His Gly Gly Tyr 
            260                 265                 270         


Leu Leu Gln Gly Lys Glu Leu Lys Ala Val Gln Asp Val Ile Leu Lys 
        275                 280                 285             


Asn Gly Ala Leu Asn Ala Ala Ile Val Gly Gln Pro Ala Tyr Lys Ile 
    290                 295                 300                 


Ala Glu Leu Ala Gly Phe Ser Val Pro Glu Asn Thr Lys Ile Leu Ile 
305                 310                 315                 320 


Gly Glu Val Thr Val Val Asp Glu Ser Glu Pro Phe Ala His Glu Lys 
                325                 330                 335     


Leu Ser Pro Thr Leu Ala Met Tyr Arg Ala Lys Asp Phe Glu Asp Ala 
            340                 345                 350         


Val Glu Lys Ala Glu Lys Leu Val Ala Met Gly Gly Ile Gly His Thr 
        355                 360                 365             


Ser Cys Leu Tyr Thr Asp Gln Asp Asn Gln Pro Ala Arg Val Ser Tyr 
    370                 375                 380                 


Phe Gly Gln Lys Met Lys Thr Ala Arg Ile Leu Ile Asn Thr Pro Ala 
385                 390                 395                 400 


Ser Gln Gly Gly Ile Gly Asp Leu Tyr Asn Phe Lys Leu Ala Pro Ser 
                405                 410                 415     


Leu Thr Leu Gly Cys Gly Ser Trp Gly Gly Asn Ser Ile Ser Glu Asn 
            420                 425                 430         


Val Gly Pro Lys His Leu Ile Asn Lys Lys Thr Val Ala Lys Arg Ala 
        435                 440                 445             


Glu Asn Met Leu Trp His Lys Leu Pro Lys Ser Ile Tyr Phe Arg Arg 
    450                 455                 460                 


Gly Ser Leu Pro Ile Ala Leu Asp Glu Val Ile Thr Asp Gly His Lys 
465                 470                 475                 480 


Arg Ala Leu Ile Val Thr Asp Arg Phe Leu Phe Asn Asn Gly Tyr Ala 
                485                 490                 495     


Asp Gln Ile Thr Ser Val Leu Lys Ala Ala Gly Val Glu Thr Glu Val 
            500                 505                 510         


Phe Phe Glu Val Glu Ala Asp Pro Thr Leu Ser Ile Val Arg Lys Gly 
        515                 520                 525             


Ala Glu Leu Ala Asn Ser Phe Lys Pro Asp Val Ile Ile Ala Leu Gly 
    530                 535                 540                 


Gly Gly Ser Pro Met Asp Ala Ala Lys Ile Met Trp Val Met Tyr Glu 
545                 550                 555                 560 


His Pro Glu Thr His Phe Glu Glu Leu Ala Leu Arg Phe Met Asp Ile 
                565                 570                 575     


Arg Lys Arg Ile Tyr Lys Phe Pro Lys Met Gly Val Lys Ala Lys Met 
            580                 585                 590         


Ile Ala Val Thr Thr Thr Ser Gly Thr Gly Ser Glu Val Thr Pro Phe 
        595                 600                 605             


Ala Val Val Thr Asp Asp Ala Thr Gly Gln Lys Tyr Pro Leu Ala Asp 
    610                 615                 620                 


Tyr Ala Leu Thr Pro Asp Met Ala Ile Val Asp Ala Asn Leu Val Met 
625                 630                 635                 640 


Asp Met Pro Lys Ser Leu Cys Ala Phe Gly Gly Leu Asp Ala Val Thr 
                645                 650                 655     


His Ala Met Glu Ala Tyr Val Ser Val Leu Ala Ser Glu Phe Ser Asp 
            660                 665                 670         


Gly Gln Ala Leu Gln Ala Leu Lys Leu Leu Lys Glu Tyr Leu Pro Ala 
        675                 680                 685             


Ser Tyr His Glu Gly Ser Lys Asn Pro Val Ala Arg Glu Arg Val His 
    690                 695                 700                 


Ser Ala Ala Thr Ile Ala Gly Ile Ala Phe Ala Asn Ala Phe Leu Gly 
705                 710                 715                 720 


Val Cys His Ser Met Ala His Lys Leu Gly Ser Gln Phe His Ile Pro 
                725                 730                 735     


His Gly Leu Ala Asn Ala Leu Leu Ile Cys Asn Val Ile Arg Tyr Asn 
            740                 745                 750         


Ala Asn Asp Asn Pro Thr Lys Gln Thr Ala Phe Ser Gln Tyr Asp Arg 
        755                 760                 765             


Pro Gln Ala Arg Arg Arg Tyr Ala Glu Ile Ala Asp His Leu Gly Leu 
    770                 775                 780                 


Ser Ala Pro Gly Asp Arg Thr Ala Ala Lys Ile Glu Lys Leu Leu Ala 
785                 790                 795                 800 


Trp Leu Glu Thr Leu Lys Ala Glu Leu Gly Ile Pro Lys Ser Ile Arg 
                805                 810                 815     


Glu Ala Gly Val Gln Glu Ala Asp Phe Leu Ala Asn Val Asp Lys Leu 
            820                 825                 830         


Ser Glu Asp Ala Phe Asp Asp Gln Cys Thr Gly Ala Asn Pro Arg Tyr 
        835                 840                 845             


Pro Leu Ile Ser Glu Leu Lys Gln Ile Leu Leu Asp Thr Tyr Tyr Gly 
    850                 855                 860                 


Arg Asp Tyr Val Glu Gly Glu Thr Ala Ala Lys Lys Glu Ala Ala Pro 
865                 870                 875                 880 


Ala Lys Ala Glu Lys Lys Ala Lys Lys Ser Ala 
                885                 890     


<210>  9
<211>  990
<212>  DNA
<213>  E.coli

<400>  9
atgaaactcg ccgtttatag cacaaaacag tacgacaaga agtacctgca acaggtgaac       60

gagtcctttg gctttgagct ggaatttttt gactttctgc tgacggaaaa aaccgctaaa      120

actgccaatg gctgcgaagc ggtatgtatt ttcgtaaacg atgacggcag ccgcccggtg      180

ctggaagagc tgaaaaagca cggcgttaaa tatatcgccc tgcgctgtgc cggtttcaat      240

aacgtcgacc ttgacgcggc aaaagaactg gggctgaaag tagtccgtgt tccagcctat      300

gatccagagg ccgttgctga acacgccatc ggtatgatga tgacgctgaa ccgccgtatt      360

caccgcgcgt atcagcgtac ccgtgacgct aacttctctc tggaaggtct gaccggcttt      420

actatgtatg gcaaaacggc aggcgttatc ggtaccggta aaatcggtgt ggcgatgctg      480

cgcattctga aaggttttgg tatgcgtctg ctggcgttcg atccgtatcc aagtgcagcg      540

gcgctggaac tcggtgtgga gtatgtcgat ctgccaaccc tgttctctga atcagacgtt      600

atctctctgc actgcccgct gacaccggaa aactaccatc tgttgaacga agccgccttc      660

gatcagatga aaaatggcgt gatgatcgtc aataccagtc gcggtgcatt gattgattct      720

caggcagcaa ttgaagcgct gaaaaatcag aaaattggtt cgttgggtat ggacgtgtat      780

gagaacgaac gcgatctatt ctttgaagat aaatccaacg acgtaattca ggatgacgta      840

ttccgtcgcc tgtctgcctg ccacaacgtg ctatttaccg ggcaccaggc attcctgaca      900

gcagaagctc tgaccagtat ttctcagact acgctgcaaa acttaagcaa tctggaaaaa      960

ggcgaaacct gcccgaacga actggtttaa                                       990


<210>  10
<211>  329
<212>  PRT
<213>  E.coli

<400>  10

Met Lys Leu Ala Val Tyr Ser Thr Lys Gln Tyr Asp Lys Lys Tyr Leu 
1               5                   10                  15      


Gln Gln Val Asn Glu Ser Phe Gly Phe Glu Leu Glu Phe Phe Asp Phe 
            20                  25                  30          


Leu Leu Thr Glu Lys Thr Ala Lys Thr Ala Asn Gly Cys Glu Ala Val 
        35                  40                  45              


Cys Ile Phe Val Asn Asp Asp Gly Ser Arg Pro Val Leu Glu Glu Leu 
    50                  55                  60                  


Lys Lys His Gly Val Lys Tyr Ile Ala Leu Arg Cys Ala Gly Phe Asn 
65                  70                  75                  80  


Asn Val Asp Leu Asp Ala Ala Lys Glu Leu Gly Leu Lys Val Val Arg 
                85                  90                  95      


Val Pro Ala Tyr Asp Pro Glu Ala Val Ala Glu His Ala Ile Gly Met 
            100                 105                 110         


Met Met Thr Leu Asn Arg Arg Ile His Arg Ala Tyr Gln Arg Thr Arg 
        115                 120                 125             


Asp Ala Asn Phe Ser Leu Glu Gly Leu Thr Gly Phe Thr Met Tyr Gly 
    130                 135                 140                 


Lys Thr Ala Gly Val Ile Gly Thr Gly Lys Ile Gly Val Ala Met Leu 
145                 150                 155                 160 


Arg Ile Leu Lys Gly Phe Gly Met Arg Leu Leu Ala Phe Asp Pro Tyr 
                165                 170                 175     


Pro Ser Ala Ala Ala Leu Glu Leu Gly Val Glu Tyr Val Asp Leu Pro 
            180                 185                 190         


Thr Leu Phe Ser Glu Ser Asp Val Ile Ser Leu His Cys Pro Leu Thr 
        195                 200                 205             


Pro Glu Asn Tyr His Leu Leu Asn Glu Ala Ala Phe Asp Gln Met Lys 
    210                 215                 220                 


Asn Gly Val Met Ile Val Asn Thr Ser Arg Gly Ala Leu Ile Asp Ser 
225                 230                 235                 240 


Gln Ala Ala Ile Glu Ala Leu Lys Asn Gln Lys Ile Gly Ser Leu Gly 
                245                 250                 255     


Met Asp Val Tyr Glu Asn Glu Arg Asp Leu Phe Phe Glu Asp Lys Ser 
            260                 265                 270         


Asn Asp Val Ile Gln Asp Asp Val Phe Arg Arg Leu Ser Ala Cys His 
        275                 280                 285             


Asn Val Leu Phe Thr Gly His Gln Ala Phe Leu Thr Ala Glu Ala Leu 
    290                 295                 300                 


Thr Ser Ile Ser Gln Thr Thr Leu Gln Asn Leu Ser Asn Leu Glu Lys 
305                 310                 315                 320 


Gly Glu Thr Cys Pro Asn Glu Leu Val 
                325                 


<210>  11
<211>  2145
<212>  DNA
<213>  E.coli

<400>  11
gtgtcccgta ttattatgct gatccctacc ggaaccagcg tcggtctgac cagcgtcagc       60

cttggcgtga tccgtgcaat ggaacgcaaa ggcgttcgtc tgagcgtttt caaacctatc      120

gctcagccgc gtaccggtgg cgatgcgccc gatcagacta cgactatcgt gcgtgcgaac      180

tcttccacca cgacggccgc tgaaccgctg aaaatgagct acgttgaagg tctgctttcc      240

agcaatcaga aagatgtgct gatggaagag atcgtcgcaa actaccacgc taacaccaaa      300

gacgctgaag tcgttctggt tgaaggtctg gtcccgacac gtaagcacca gtttgcccag      360

tctctgaact acgaaatcgc taaaacgctg aatgcggaaa tcgtcttcgt tatgtctcag      420

ggcactgaca ccccggaaca gctgaaagag cgtatcgaac tgacccgcaa cagcttcggc      480

ggtgccaaaa acaccaacat caccggcgtt atcgttaaca aactgaacgc accggttgat      540

gaacagggtc gtactcgccc ggatctgtcc gagattttcg acgactcttc caaagctaaa      600

gtaaacaatg ttgatccggc gaagctgcaa gaatccagcc cgctgccggt tctcggcgct      660

gtgccgtgga gctttgacct gatcgcgact cgtgcgatcg atatggctcg ccacctgaat      720

gcgaccatca tcaacgaagg cgacatcaat actcgccgcg ttaaatccgt cactttctgc      780

gcacgcagca ttccgcacat gctggagcac ttccgtgccg gttctctgct ggtgacttcc      840

gcagaccgtc ctgacgtgct ggtggccgct tgcctggcag ccatgaacgg cgtagaaatc      900

ggtgccctgc tgctgactgg cggctacgaa atggacgcgc gcatttctaa actgtgcgaa      960

cgtgctttcg ctaccggcct gccggtattt atggtgaaca ccaacacctg gcagacctct     1020

ctgagcctgc agagcttcaa cctggaagtt ccggttgacg atcacgagcg tatcgagaaa     1080

gttcaggaat acgttgctaa ctacatcaac gctgactgga tcgaatctct gactgccact     1140

tctgagcgca gccgtcgtct gtctccgcct gcgttccgtt atcagctgac tgaacttgcg     1200

cgcaaagcgg gcaaacgtat cgtactgccg gaaggtgacg aaccgcgtac cgttaaagca     1260

gccgctatct gtgctgaacg tggtatcgca acttgcgtac tgctgggtaa tccggcagag     1320

atcaaccgtg ttgcagcgtc tcagggtgta gaactgggtg cagggattga aatcgttgat     1380

ccagaagtgg ttcgcgaaag ctatgttggt cgtctggtcg aactgcgtaa gaacaaaggc     1440

atgaccgaaa ccgttgcccg cgaacagctg gaagacaacg tggtgctcgg tacgctgatg     1500

ctggaacagg atgaagttga tggtctggtt tccggtgctg ttcacactac cgcaaacacc     1560

atccgtccgc cgctgcagct gatcaaaact gcaccgggca gctccctggt atcttccgtg     1620

ttcttcatgc tgctgccgga acaggtttac gtttacggtg actgtgcgat caacccggat     1680

ccgaccgctg aacagctggc agaaatcgcg attcagtccg ctgattccgc tgcggccttc     1740

ggtatcgaac cgcgcgttgc tatgctctcc tactccaccg gtacttctgg tgcaggtagc     1800

gacgtagaaa aagttcgcga agcaactcgt ctggcgcagg aaaaacgtcc tgacctgatg     1860

atcgacggtc cgctgcagta cgacgctgcg gtaatggctg acgttgcgaa atccaaagcg     1920

ccgaactctc cggttgcagg tcgcgctacc gtgttcatct tcccggatct gaacaccggt     1980

aacaccacct acaaagcggt acagcgttct gccgacctga tctccatcgg gccgatgctg     2040

cagggtatgc gcaagccggt taacgacctg tcccgtggcg cactggttga cgatatcgtc     2100

tacaccatcg cgctgactgc gattcagtct gcacagcagc agtaa                     2145


<210>  12
<211>  714
<212>  PRT
<213>  E.coli

<400>  12

Met Ser Arg Ile Ile Met Leu Ile Pro Thr Gly Thr Ser Val Gly Leu 
1               5                   10                  15      


Thr Ser Val Ser Leu Gly Val Ile Arg Ala Met Glu Arg Lys Gly Val 
            20                  25                  30          


Arg Leu Ser Val Phe Lys Pro Ile Ala Gln Pro Arg Thr Gly Gly Asp 
        35                  40                  45              


Ala Pro Asp Gln Thr Thr Thr Ile Val Arg Ala Asn Ser Ser Thr Thr 
    50                  55                  60                  


Thr Ala Ala Glu Pro Leu Lys Met Ser Tyr Val Glu Gly Leu Leu Ser 
65                  70                  75                  80  


Ser Asn Gln Lys Asp Val Leu Met Glu Glu Ile Val Ala Asn Tyr His 
                85                  90                  95      


Ala Asn Thr Lys Asp Ala Glu Val Val Leu Val Glu Gly Leu Val Pro 
            100                 105                 110         


Thr Arg Lys His Gln Phe Ala Gln Ser Leu Asn Tyr Glu Ile Ala Lys 
        115                 120                 125             


Thr Leu Asn Ala Glu Ile Val Phe Val Met Ser Gln Gly Thr Asp Thr 
    130                 135                 140                 


Pro Glu Gln Leu Lys Glu Arg Ile Glu Leu Thr Arg Asn Ser Phe Gly 
145                 150                 155                 160 


Gly Ala Lys Asn Thr Asn Ile Thr Gly Val Ile Val Asn Lys Leu Asn 
                165                 170                 175     


Ala Pro Val Asp Glu Gln Gly Arg Thr Arg Pro Asp Leu Ser Glu Ile 
            180                 185                 190         


Phe Asp Asp Ser Ser Lys Ala Lys Val Asn Asn Val Asp Pro Ala Lys 
        195                 200                 205             


Leu Gln Glu Ser Ser Pro Leu Pro Val Leu Gly Ala Val Pro Trp Ser 
    210                 215                 220                 


Phe Asp Leu Ile Ala Thr Arg Ala Ile Asp Met Ala Arg His Leu Asn 
225                 230                 235                 240 


Ala Thr Ile Ile Asn Glu Gly Asp Ile Asn Thr Arg Arg Val Lys Ser 
                245                 250                 255     


Val Thr Phe Cys Ala Arg Ser Ile Pro His Met Leu Glu His Phe Arg 
            260                 265                 270         


Ala Gly Ser Leu Leu Val Thr Ser Ala Asp Arg Pro Asp Val Leu Val 
        275                 280                 285             


Ala Ala Cys Leu Ala Ala Met Asn Gly Val Glu Ile Gly Ala Leu Leu 
    290                 295                 300                 


Leu Thr Gly Gly Tyr Glu Met Asp Ala Arg Ile Ser Lys Leu Cys Glu 
305                 310                 315                 320 


Arg Ala Phe Ala Thr Gly Leu Pro Val Phe Met Val Asn Thr Asn Thr 
                325                 330                 335     


Trp Gln Thr Ser Leu Ser Leu Gln Ser Phe Asn Leu Glu Val Pro Val 
            340                 345                 350         


Asp Asp His Glu Arg Ile Glu Lys Val Gln Glu Tyr Val Ala Asn Tyr 
        355                 360                 365             


Ile Asn Ala Asp Trp Ile Glu Ser Leu Thr Ala Thr Ser Glu Arg Ser 
    370                 375                 380                 


Arg Arg Leu Ser Pro Pro Ala Phe Arg Tyr Gln Leu Thr Glu Leu Ala 
385                 390                 395                 400 


Arg Lys Ala Gly Lys Arg Ile Val Leu Pro Glu Gly Asp Glu Pro Arg 
                405                 410                 415     


Thr Val Lys Ala Ala Ala Ile Cys Ala Glu Arg Gly Ile Ala Thr Cys 
            420                 425                 430         


Val Leu Leu Gly Asn Pro Ala Glu Ile Asn Arg Val Ala Ala Ser Gln 
        435                 440                 445             


Gly Val Glu Leu Gly Ala Gly Ile Glu Ile Val Asp Pro Glu Val Val 
    450                 455                 460                 


Arg Glu Ser Tyr Val Gly Arg Leu Val Glu Leu Arg Lys Asn Lys Gly 
465                 470                 475                 480 


Met Thr Glu Thr Val Ala Arg Glu Gln Leu Glu Asp Asn Val Val Leu 
                485                 490                 495     


Gly Thr Leu Met Leu Glu Gln Asp Glu Val Asp Gly Leu Val Ser Gly 
            500                 505                 510         


Ala Val His Thr Thr Ala Asn Thr Ile Arg Pro Pro Leu Gln Leu Ile 
        515                 520                 525             


Lys Thr Ala Pro Gly Ser Ser Leu Val Ser Ser Val Phe Phe Met Leu 
    530                 535                 540                 


Leu Pro Glu Gln Val Tyr Val Tyr Gly Asp Cys Ala Ile Asn Pro Asp 
545                 550                 555                 560 


Pro Thr Ala Glu Gln Leu Ala Glu Ile Ala Ile Gln Ser Ala Asp Ser 
                565                 570                 575     


Ala Ala Ala Phe Gly Ile Glu Pro Arg Val Ala Met Leu Ser Tyr Ser 
            580                 585                 590         


Thr Gly Thr Ser Gly Ala Gly Ser Asp Val Glu Lys Val Arg Glu Ala 
        595                 600                 605             


Thr Arg Leu Ala Gln Glu Lys Arg Pro Asp Leu Met Ile Asp Gly Pro 
    610                 615                 620                 


Leu Gln Tyr Asp Ala Ala Val Met Ala Asp Val Ala Lys Ser Lys Ala 
625                 630                 635                 640 


Pro Asn Ser Pro Val Ala Gly Arg Ala Thr Val Phe Ile Phe Pro Asp 
                645                 650                 655     


Leu Asn Thr Gly Asn Thr Thr Tyr Lys Ala Val Gln Arg Ser Ala Asp 
            660                 665                 670         


Leu Ile Ser Ile Gly Pro Met Leu Gln Gly Met Arg Lys Pro Val Asn 
        675                 680                 685             


Asp Leu Ser Arg Gly Ala Leu Val Asp Asp Ile Val Tyr Thr Ile Ala 
    690                 695                 700                 


Leu Thr Ala Ile Gln Ser Ala Gln Gln Gln 
705                 710                 


<210>  13
<211>  1809
<212>  DNA
<213>  E.coli

<400>  13
gtgcaaacct ttcaagccga tcttgccatt gtaggcgccg gtggcgcggg attacgtgct       60

gcaattgctg ccgcgcaggc aaatccgaat gcaaaaatcg cactaatctc aaaagtatac      120

ccgatgcgta gccataccgt tgctgcagaa gggggctccg ccgctgtcgc gcaggatcat      180

gacagcttcg aatatcactt tcacgataca gtagcgggtg gcgactggtt gtgtgagcag      240

gatgtcgtgg attatttcgt ccaccactgc ccaaccgaaa tgacccaact ggaactgtgg      300

ggatgcccat ggagccgtcg cccggatggt agcgtcaacg tacgtcgctt cggcggcatg      360

aaaatcgagc gcacctggtt cgccgccgat aagaccggct tccatatgct gcacacgctg      420

ttccagacct ctctgcaatt cccgcagatc cagcgttttg acgaacattt cgtgctggat      480

attctggttg atgatggtca tgttcgcggc ctggtagcaa tgaacatgat ggaaggcacg      540

ctggtgcaga tccgtgctaa cgcggtcgtt atggctactg gcggtgcggg tcgcgtttat      600

cgttacaaca ccaacggcgg catcgttacc ggtgacggta tgggtatggc gctaagccac      660

ggcgttccgc tgcgtgacat ggaattcgtt cagtatcacc caaccggtct gccaggttcc      720

ggtatcctga tgaccgaagg ctgccgcggt gaaggcggta ttctggtcaa caaaaatggc      780

taccgttatc tgcaagatta cggcatgggc ccggaaactc cgctgggcga gccgaaaaac      840

aaatatatgg aactgggtcc acgcgacaaa gtttctcagg ccttctggca cgaatggcgt      900

aaaggcaaca ccatctccac gccgcgtggc gatgtggttt atctcgacct gcgtcacctc      960

ggcgagaaaa aactgcatga acgtctgccg ttcatctgcg aactggcgaa agcgtacgtt     1020

ggcgtcgatc cggttaaaga accgattccg gtacgtccga ccgcacacta caccatgggc     1080

ggtatcgaaa ccgatcagaa ctgtgaaacc cgcattaaag gtctgttcgc cgtgggtgaa     1140

tgttcctctg ttggtctgca cggtgcaaac cgtctgggtt ctaactccct ggcggaactg     1200

gtggtcttcg gccgtctggc cggtgaacaa gcgacagagc gtgcagcaac tgccggtaat     1260

ggcaacgaag cggcaattga agcgcaggca gctggcgttg aacaacgtct gaaagatctg     1320

gttaaccagg atggcggcga aaactgggcg aagatccgcg acgaaatggg cctggcaatg     1380

gaagaaggtt gcggtatcta ccgtacgccg gaactgatgc agaaaaccat cgacaagctg     1440

gcagagctgc aggaacgctt caagcgcgtg cgcatcaccg acacctccag cgtgttcaac     1500

accgacctgc tctacaccat tgaactgggc cacggtctga acgttgctga atgtatggcg     1560

cactccgcaa tggcacgtaa agagtcccgc ggcgcacacc agcgtctgga cgaaggttgc     1620

accgagcgtg acgacgtcaa cttcctcaaa cacaccctcg ccttccgcga tgctgatggc     1680

acgactcgcc tggagtacag cgacgtgaag attactacgc tgccgccagc taaacgcgtt     1740

tacggtggcg aagcggatgc agccgataag gcggaagcag ccaataagaa ggagaaggcg     1800

aatggctga                                                             1809


<210>  14
<211>  602
<212>  PRT
<213>  E.coli

<400>  14

Met Gln Thr Phe Gln Ala Asp Leu Ala Ile Val Gly Ala Gly Gly Ala 
1               5                   10                  15      


Gly Leu Arg Ala Ala Ile Ala Ala Ala Gln Ala Asn Pro Asn Ala Lys 
            20                  25                  30          


Ile Ala Leu Ile Ser Lys Val Tyr Pro Met Arg Ser His Thr Val Ala 
        35                  40                  45              


Ala Glu Gly Gly Ser Ala Ala Val Ala Gln Asp His Asp Ser Phe Glu 
    50                  55                  60                  


Tyr His Phe His Asp Thr Val Ala Gly Gly Asp Trp Leu Cys Glu Gln 
65                  70                  75                  80  


Asp Val Val Asp Tyr Phe Val His His Cys Pro Thr Glu Met Thr Gln 
                85                  90                  95      


Leu Glu Leu Trp Gly Cys Pro Trp Ser Arg Arg Pro Asp Gly Ser Val 
            100                 105                 110         


Asn Val Arg Arg Phe Gly Gly Met Lys Ile Glu Arg Thr Trp Phe Ala 
        115                 120                 125             


Ala Asp Lys Thr Gly Phe His Met Leu His Thr Leu Phe Gln Thr Ser 
    130                 135                 140                 


Leu Gln Phe Pro Gln Ile Gln Arg Phe Asp Glu His Phe Val Leu Asp 
145                 150                 155                 160 


Ile Leu Val Asp Asp Gly His Val Arg Gly Leu Val Ala Met Asn Met 
                165                 170                 175     


Met Glu Gly Thr Leu Val Gln Ile Arg Ala Asn Ala Val Val Met Ala 
            180                 185                 190         


Thr Gly Gly Ala Gly Arg Val Tyr Arg Tyr Asn Thr Asn Gly Gly Ile 
        195                 200                 205             


Val Thr Gly Asp Gly Met Gly Met Ala Leu Ser His Gly Val Pro Leu 
    210                 215                 220                 


Arg Asp Met Glu Phe Val Gln Tyr His Pro Thr Gly Leu Pro Gly Ser 
225                 230                 235                 240 


Gly Ile Leu Met Thr Glu Gly Cys Arg Gly Glu Gly Gly Ile Leu Val 
                245                 250                 255     


Asn Lys Asn Gly Tyr Arg Tyr Leu Gln Asp Tyr Gly Met Gly Pro Glu 
            260                 265                 270         


Thr Pro Leu Gly Glu Pro Lys Asn Lys Tyr Met Glu Leu Gly Pro Arg 
        275                 280                 285             


Asp Lys Val Ser Gln Ala Phe Trp His Glu Trp Arg Lys Gly Asn Thr 
    290                 295                 300                 


Ile Ser Thr Pro Arg Gly Asp Val Val Tyr Leu Asp Leu Arg His Leu 
305                 310                 315                 320 


Gly Glu Lys Lys Leu His Glu Arg Leu Pro Phe Ile Cys Glu Leu Ala 
                325                 330                 335     


Lys Ala Tyr Val Gly Val Asp Pro Val Lys Glu Pro Ile Pro Val Arg 
            340                 345                 350         


Pro Thr Ala His Tyr Thr Met Gly Gly Ile Glu Thr Asp Gln Asn Cys 
        355                 360                 365             


Glu Thr Arg Ile Lys Gly Leu Phe Ala Val Gly Glu Cys Ser Ser Val 
    370                 375                 380                 


Gly Leu His Gly Ala Asn Arg Leu Gly Ser Asn Ser Leu Ala Glu Leu 
385                 390                 395                 400 


Val Val Phe Gly Arg Leu Ala Gly Glu Gln Ala Thr Glu Arg Ala Ala 
                405                 410                 415     


Thr Ala Gly Asn Gly Asn Glu Ala Ala Ile Glu Ala Gln Ala Ala Gly 
            420                 425                 430         


Val Glu Gln Arg Leu Lys Asp Leu Val Asn Gln Asp Gly Gly Glu Asn 
        435                 440                 445             


Trp Ala Lys Ile Arg Asp Glu Met Gly Leu Ala Met Glu Glu Gly Cys 
    450                 455                 460                 


Gly Ile Tyr Arg Thr Pro Glu Leu Met Gln Lys Thr Ile Asp Lys Leu 
465                 470                 475                 480 


Ala Glu Leu Gln Glu Arg Phe Lys Arg Val Arg Ile Thr Asp Thr Ser 
                485                 490                 495     


Ser Val Phe Asn Thr Asp Leu Leu Tyr Thr Ile Glu Leu Gly His Gly 
            500                 505                 510         


Leu Asn Val Ala Glu Cys Met Ala His Ser Ala Met Ala Arg Lys Glu 
        515                 520                 525             


Ser Arg Gly Ala His Gln Arg Leu Asp Glu Gly Cys Thr Glu Arg Asp 
    530                 535                 540                 


Asp Val Asn Phe Leu Lys His Thr Leu Ala Phe Arg Asp Ala Asp Gly 
545                 550                 555                 560 


Thr Thr Arg Leu Glu Tyr Ser Asp Val Lys Ile Thr Thr Leu Pro Pro 
                565                 570                 575     


Ala Lys Arg Val Tyr Gly Gly Glu Ala Asp Ala Ala Asp Lys Ala Glu 
            580                 585                 590         


Ala Ala Asn Lys Lys Glu Lys Ala Asn Gly 
        595                 600         


<210>  15
<211>  1119
<212>  DNA
<213>  G.stearothermophilus

<400>  15
atgaaaattg gcatccctaa agagattaag aacaatgaaa accgtgtagc aatcaccccg       60

gcaggtgtta tgactctggt taaagcgggc cacgatgtgt acgtcgaaac cgaagcgggt      120

gccggcagcg gcttcagcga cagcgagtat gagaaggcgg gtgcggttat tgtgactaag      180

gcggaggacg cttgggcagc cgaaatggtt ctgaaggtga aagaaccgct ggcggaggag      240

tttcgctatt ttcgtccggg tctgattttg ttcacctacc tgcacctggc tgcggccgag      300

gcgctgacca aggcactggt ggagcagaag gttgttggca tcgcgtacga aacggttcaa      360

ctggcgaatg gttccctgcc gctgctgacc cctatgtctg aagttgcggg tcgcatgagc      420

gttcaagtcg gcgctcagtt tctggagaaa ccgcacggtg gcaagggcat tttgctgggt      480

ggtgttccgg gtgtccgccg tggtaaagtg acgatcattg gcggtggtac ggccggtacg      540

aacgcggcca agattgccgt aggtctgggt gcagatgtga ccattctgga catcaacgcg      600

gaacgtttgc gtgagctgga cgacctgttt ggcgaccaag tcaccaccct gatgagcaac      660

agctaccaca tcgcggagtg cgtccgtgaa agcgatttgg tcgttggtgc ggtgctgatc      720

ccgggtgcaa aagccccgaa actggtgacc gaggagatgg tccgtagcat gaccccgggt      780

tcggttctgg tcgacgtggc aattgaccag ggcggtatct tcgaaaccac cgaccgcgtc      840

acgacccatg atgacccgac ctatgtgaaa catggcgtgg ttcactatgc ggtcgcgaat      900

atgccgggtg cagtgccgcg cacgtccacg ttcgcgctga cgaacgtgac gattccatac      960

gctctgcaga tcgccaataa gggctatcgt gcggcgtgtc tggataatcc ggcattgctg     1020

aaaggcatca ataccctgga tggtcatatc gtttacgagg ctgtggctgc agcacacaac     1080

atgccgtaca ctgatgtcca tagcttgctg caaggctaa                            1119


<210>  16
<211>  372
<212>  PRT
<213>  G.stearothermophilus

<400>  16

Met Lys Ile Gly Ile Pro Lys Glu Ile Lys Asn Asn Glu Asn Arg Val 
1               5                   10                  15      


Ala Ile Thr Pro Ala Gly Val Met Thr Leu Val Lys Ala Gly His Asp 
            20                  25                  30          


Val Tyr Val Glu Thr Glu Ala Gly Ala Gly Ser Gly Phe Ser Asp Ser 
        35                  40                  45              


Glu Tyr Glu Lys Ala Gly Ala Val Ile Val Thr Lys Ala Glu Asp Ala 
    50                  55                  60                  


Trp Ala Ala Glu Met Val Leu Lys Val Lys Glu Pro Leu Ala Glu Glu 
65                  70                  75                  80  


Phe Arg Tyr Phe Arg Pro Gly Leu Ile Leu Phe Thr Tyr Leu His Leu 
                85                  90                  95      


Ala Ala Ala Glu Ala Leu Thr Lys Ala Leu Val Glu Gln Lys Val Val 
            100                 105                 110         


Gly Ile Ala Tyr Glu Thr Val Gln Leu Ala Asn Gly Ser Leu Pro Leu 
        115                 120                 125             


Leu Thr Pro Met Ser Glu Val Ala Gly Arg Met Ser Val Gln Val Gly 
    130                 135                 140                 


Ala Gln Phe Leu Glu Lys Pro His Gly Gly Lys Gly Ile Leu Leu Gly 
145                 150                 155                 160 


Gly Val Pro Gly Val Arg Arg Gly Lys Val Thr Ile Ile Gly Gly Gly 
                165                 170                 175     


Thr Ala Gly Thr Asn Ala Ala Lys Ile Ala Val Gly Leu Gly Ala Asp 
            180                 185                 190         


Val Thr Ile Leu Asp Ile Asn Ala Glu Arg Leu Arg Glu Leu Asp Asp 
        195                 200                 205             


Leu Phe Gly Asp Gln Val Thr Thr Leu Met Ser Asn Ser Tyr His Ile 
    210                 215                 220                 


Ala Glu Cys Val Arg Glu Ser Asp Leu Val Val Gly Ala Val Leu Ile 
225                 230                 235                 240 


Pro Gly Ala Lys Ala Pro Lys Leu Val Thr Glu Glu Met Val Arg Ser 
                245                 250                 255     


Met Thr Pro Gly Ser Val Leu Val Asp Val Ala Ile Asp Gln Gly Gly 
            260                 265                 270         


Ile Phe Glu Thr Thr Asp Arg Val Thr Thr His Asp Asp Pro Thr Tyr 
        275                 280                 285             


Val Lys His Gly Val Val His Tyr Ala Val Ala Asn Met Pro Gly Ala 
    290                 295                 300                 


Val Pro Arg Thr Ser Thr Phe Ala Leu Thr Asn Val Thr Ile Pro Tyr 
305                 310                 315                 320 


Ala Leu Gln Ile Ala Asn Lys Gly Tyr Arg Ala Ala Cys Leu Asp Asn 
                325                 330                 335     


Pro Ala Leu Leu Lys Gly Ile Asn Thr Leu Asp Gly His Ile Val Tyr 
            340                 345                 350         


Glu Ala Val Ala Ala Ala His Asn Met Pro Tyr Thr Asp Val His Ser 
        355                 360                 365             


Leu Leu Gln Gly 
    370         


<210>  17
<211>  20
<212>  DNA
<213>  Artificial


<220>
<223>  Primer


<400>  17
actgcggtag ttcttcactg                                                   20


<210>  18
<211>  21
<212>  DNA
<213>  Artificial


<220>
<223>  Primer

<400>  18
agtacctttc tggtttagcc g                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial


<220>
<223>  Primer

<400>  19
gatagcagaa acggaaccac                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial


<220>
<223>  Primer

<400>  20
ggtgctgttc acactaccgc                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial


<220>
<223>  Primer

<400>  21
tgacgagatt actgctgctg                                                   20


<210>  22
<211>  21
<212>  DNA
<213>  Artificial


<220>
<223>  Primer

<400>  22
atttccggtt cagatatccg c                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial


<220>
<223>  Primer

<400>  23
gggttgacca gcgcaaataa c                                                 21


<210>  24
<211>  23
<212>  DNA
<213>  Artificial


<220>
<223>  Primer

<400>  24
cagaagtgag taatcttgct tac                                               23


<210>  25
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  25
gatcacttta tcttcgacga tac                                               23


<210>  26
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  26
gcgaacgtgg ataaactgtc tg                                                22


<210>  27
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  27
gctcttaagc accgacgttg ac                                                22


<210>  28
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  28
gtcggctcat taacggctat tc                                                22


<210>  29
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer
<400>  29
gacggatctc cgccataatc                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  30
tcgccacccg ctactgtatc                                                   20


<210>  31
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  31
caaagcgttc tgacgaaccg g                                                 21


<210>  32
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  32
tgtgcgatgc acaatatcgt tg                                                22


<210>  33
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer
<400>  33
ttggttgggt tgacatactg g                                                 21


<210>  34
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  34
tgaacttcat cactgataac c                                                 21


<210>  35
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  35
ttcaaaggag tgaatgcgac c                                                 21


<210>  36
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  36
gtcgcggtta tgacaataca gg                                                22


<210>  37
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  37
taccgtgccg acgttcaata ac                                                22


<210>  38
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  38
catcagcagg cttagcgcaa c                                                 21


<210>  39
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  39
acctttacgc gtaatgcgtg                                                   20


<210>  40
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  40
accgtttacg ctttccagca c                                                 21


<210>  41
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  41
cgaattatcg atctcgctca ac                                                22


<210>  42
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  42
cgtctatatt gctgaaggta cag                                               23


<210>  43
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  43
tcgaaggtcc attcacgcaa c                                                 21


<210>  44
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  44
gattcccacc gcaacgttag                                                   20

<210>  45
<211>  1095
<212>  DNA
<213>  Escherichia coli

<400>  45
atggcacaac agactccttt gtacgaacaa cacacgcttt gcggcgctcg catggtggat       60

ttccacggct ggatgatgcc gctgcattac ggttcgcaaa tcgacgaaca tcatgcggta      120

cgtaccgatg ccggaatgtt tgatgtgtca catatgacca tcgtcgatct ccgcggcagc      180

cgcacccggg agtttctgcg ttatctgctg gcgaacgatg tggcgaagct caccaaaagc      240

ggcaaagccc tttactcggg gatgttgaat gcctctggcg gtgtgataga tgacctcatc      300

gtctactact ttactgaaga tttcttccgc ctcgttgtta actccgccac ccgcgaaaaa      360

gacctctcct ggattaccca acacgctgaa cctttcggca tcgaaattac cgttcgtgat      420

gacctttcca tgattgccgt gcaagggccg aatgcgcagg caaaagctgc cacactgttt      480

aatgacgccc agcgtcaggc ggtggaaggg atgaaaccgt tctttggcgt gcaggcgggc      540

gatctgttta ttgccaccac tggttatacc ggtgaagcgg gctatgaaat tgcgctgccc      600

aatgaaaaag cggccgattt ctggcgtgcg ctggtggaag cgggtgttaa gccatgtggc      660

ttgggcgcgc gtgacacgct gcgtctggaa gcgggcatga atctttatgg tcaggagatg      720

gacgaaacta tttctccttt agccgccaac atgggctgga ctatcgcctg ggaaccggca      780

gatcgtgact ttatcggtcg tgaagccctg gaagtgcagc gtgagcatgg tacagaaaaa      840

ctggttggtc tggtgatgac cgaaaaaggc gtgctgcgta atgaactgcc ggtacgcttt      900

accgatgcgc agggcaacca gcatgaaggc attatcacca gcggtacttt ctccccgacg      960

ctgggttaca gcattgcgct ggcgcgcgtg ccggaaggta ttggcgaaac ggcgattgtg     1020

caaattcgca accgtgaaat gccggttaaa gtgacaaaac ctgtttttgt gcgtaacggc     1080

aaagccgtcg cgtga                                                      1095


<210>  46
<211>  364
<212>  PRT
<213>  Escherichia coli

<400>  46

Met Ala Gln Gln Thr Pro Leu Tyr Glu Gln His Thr Leu Cys Gly Ala 
1               5                   10                  15      


Arg Met Val Asp Phe His Gly Trp Met Met Pro Leu His Tyr Gly Ser 
            20                  25                  30          


Gln Ile Asp Glu His His Ala Val Arg Thr Asp Ala Gly Met Phe Asp 
        35                  40                  45              


Val Ser His Met Thr Ile Val Asp Leu Arg Gly Ser Arg Thr Arg Glu 
    50                  55                  60                  


Phe Leu Arg Tyr Leu Leu Ala Asn Asp Val Ala Lys Leu Thr Lys Ser 
65                  70                  75                  80  


Gly Lys Ala Leu Tyr Ser Gly Met Leu Asn Ala Ser Gly Gly Val Ile 
                85                  90                  95      


Asp Asp Leu Ile Val Tyr Tyr Phe Thr Glu Asp Phe Phe Arg Leu Val 
            100                 105                 110         


Val Asn Ser Ala Thr Arg Glu Lys Asp Leu Ser Trp Ile Thr Gln His 
        115                 120                 125             


Ala Glu Pro Phe Gly Ile Glu Ile Thr Val Arg Asp Asp Leu Ser Met 
    130                 135                 140                 


Ile Ala Val Gln Gly Pro Asn Ala Gln Ala Lys Ala Ala Thr Leu Phe 
145                 150                 155                 160 


Asn Asp Ala Gln Arg Gln Ala Val Glu Gly Met Lys Pro Phe Phe Gly 
                165                 170                 175     


Val Gln Ala Gly Asp Leu Phe Ile Ala Thr Thr Gly Tyr Thr Gly Glu 
            180                 185                 190         


Ala Gly Tyr Glu Ile Ala Leu Pro Asn Glu Lys Ala Ala Asp Phe Trp 
        195                 200                 205             


Arg Ala Leu Val Glu Ala Gly Val Lys Pro Cys Gly Leu Gly Ala Arg 
    210                 215                 220                 


Asp Thr Leu Arg Leu Glu Ala Gly Met Asn Leu Tyr Gly Gln Glu Met 
225                 230                 235                 240 


Asp Glu Thr Ile Ser Pro Leu Ala Ala Asn Met Gly Trp Thr Ile Ala 
                245                 250                 255     


Trp Glu Pro Ala Asp Arg Asp Phe Ile Gly Arg Glu Ala Leu Glu Val 
            260                 265                 270         


Gln Arg Glu His Gly Thr Glu Lys Leu Val Gly Leu Val Met Thr Glu 
        275                 280                 285             


Lys Gly Val Leu Arg Asn Glu Leu Pro Val Arg Phe Thr Asp Ala Gln 
    290                 295                 300                 


Gly Asn Gln His Glu Gly Ile Ile Thr Ser Gly Thr Phe Ser Pro Thr 
305                 310                 315                 320 


Leu Gly Tyr Ser Ile Ala Leu Ala Arg Val Pro Glu Gly Ile Gly Glu 
                325                 330                 335     


Thr Ala Ile Val Gln Ile Arg Asn Arg Glu Met Pro Val Lys Val Thr 
            340                 345                 350         


Lys Pro Val Phe Val Arg Asn Gly Lys Ala Val Ala 
        355                 360                 


<210>  47
<211>  390
<212>  DNA
<213>  Escherichia coli

<400>  47
atgagcaacg taccagcaga actgaaatac agcaaagaac acgaatggct gcgtaaagaa       60

gccgacggca cttacaccgt tggtattacc gaacatgctc aggagctgtt aggcgatatg      120

gtgtttgttg acctgccgga agtgggcgca acggttagcg cgggcgatga ctgcgcggtt      180

gccgaatcag taaaagcggc gtcagacatt tatgcgccag taagcggtga aatcgtggcg      240

gtaaacgacg cactgagcga ttccccggaa ctggtgaaca gcgaaccgta tgcaggtggc      300

tggatcttta aaatcaaagc cagcgatgaa agcgaactgg aatcactgct ggatgcgacc      360

gcatacgaag cattgttaga agacgagtaa                                       390


<210>  48
<211>  129
<212>  PRT
<213>  Escherichia coli

<400>  48

Met Ser Asn Val Pro Ala Glu Leu Lys Tyr Ser Lys Glu His Glu Trp 
1               5                   10                  15      


Leu Arg Lys Glu Ala Asp Gly Thr Tyr Thr Val Gly Ile Thr Glu His 
            20                  25                  30          


Ala Gln Glu Leu Leu Gly Asp Met Val Phe Val Asp Leu Pro Glu Val 
        35                  40                  45              


Gly Ala Thr Val Ser Ala Gly Asp Asp Cys Ala Val Ala Glu Ser Val 
    50                  55                  60                  


Lys Ala Ala Ser Asp Ile Tyr Ala Pro Val Ser Gly Glu Ile Val Ala 
65                  70                  75                  80  


Val Asn Asp Ala Leu Ser Asp Ser Pro Glu Leu Val Asn Ser Glu Pro 
                85                  90                  95      


Tyr Ala Gly Gly Trp Ile Phe Lys Ile Lys Ala Ser Asp Glu Ser Glu 
            100                 105                 110         


Leu Glu Ser Leu Leu Asp Ala Thr Ala Tyr Glu Ala Leu Leu Glu Asp 
        115                 120                 125             


Glu 
    


<210>  49
<211>  2874
<212>  DNA
<213>  Escherichia coli

<400>  49
atgacacaga cgttaagcca gcttgaaaac agcggcgctt ttattgaacg ccatatcgga       60

ccggacgccg cgcaacagca agaaatgctg aatgccgttg gtgcacaatc gttaaacgcg      120

ctgaccggcc agattgtgcc gaaagatatt cagcttgcga ccccgccgca ggttggcgca      180

ccggcgaccg aatacgccgc actggcagaa ctcaaggcta ttgccagtcg caataaacgc      240

ttcacgtctt acatcggcat gggttacacc gccgtgcagc taccgccggt tatcctgcgt      300

aacatgctgg aaaatccggg ctggtatacc gcgtacactc cgtatcaacc tgaagtctcc      360

cagggccgcc ttgaagcact gctcaacttc cagcaggtaa cgctggattt gactggactg      420

gatatggcct ctgcttctct tctggacgag gccaccgctg ccgccgaagc aatggcgatg      480

gcgaaacgcg tcagcaaact gaaaaatgcc aaccgcttct tcgtggcttc cgatgtgcat      540

ccgcaaacgc tggatgtggt ccgtactcgt gccgaaacct ttggttttga agtgattgtc      600

gatgacgcgc aaaaagtgct cgaccatcag gacgtcttcg gcgtgctgtt acagcaggtt      660

ggcacaaccg gtgaaatcca cgactacacc gcgcttatta gcgaactgaa atcacgcaaa      720

attgtggtca gcgttgccgc cgatattatg gcgctggtgc tgttaactgc gccgggtaaa      780

cagggcgcgg atattgtttt tggttcggcg caacgcttcg gcgtgccgat gggctacggt      840

ggcccacacg cggcattctt tgcggcgaaa gatgaataca aacgctcaat gccgggccgt      900

attatcggtg tatcgaaaga tgcagctggc aataccgcgc tgcgcatggc gatgcagact      960

cgcgagcaac atatccgccg tgagaaagcg aactccaaca tttgtacttc ccaggtactg     1020

ctggcaaaca tcgccagcct gtatgccgtt tatcacggcc cgattggcct gaaacgtatc     1080

gctaaccgca ttcaccgttt gaccgatatc ctggcggcag gcctgcaaca aaaaggtctg     1140

aagctgcgcc atgcgcacta tttcgacacc ttgtgtgtgg aagtggccga caaagcgggc     1200

gtactgacgc gtgccgaagc ggctgaaatc aacctgcgta gcgatattct gaacgcggtt     1260

gggatcaccc ttgatgaaac aaccacgcgt gaaaacgtaa tgcagctttt caacgtgctg     1320

ctgggcgata accacggcct ggacatcgac acgctggaca aagacgtggc tcacgacagc     1380

cgctctatcc agcctgcgat gctgcgcgac gacgaaatcc tcacccatcc ggtgtttaat     1440

cgctaccaca gcgaaaccga aatgatgcgc tatatgcact cgctggagcg taaagatctg     1500

gcgctgaatc aggcgatgat cccgctgggt tcctgcacca tgaaactgaa cgccgccgcc     1560

gagatgatcc caatcacctg gccggaattt gccgaactgc acccgttttg tccgccggaa     1620

caggctgaag gttatcagca gatgattgcg cagctggctg actggctggt gaaactgacc     1680

ggttacgacg ccgtttgtat gcagccgaac tccggcgcac agggcgaata cgcgggcctg     1740

ctggcgattc gtcattatca tgaaagccgc aacgaagggc atcgcgatat ctgcctgatc     1800

ccggcttctg cgcacggaac taaccccgct tctgcacata tggcaggaat gcaggtggtg     1860

gttgtggcgt gtgataaaaa cggcaacatc gatctgactg atctgcgcgc gaaagcggaa     1920

caggcgggcg ataacctctc ctgtatcatg gtgacttatc cttctaccca cggcgtgtat     1980

gaagaaacga tccgtgaagt gtgtgaagtc gtgcatcagt tcggcggtca ggtttacctt     2040

gatggcgcga acatgaacgc ccaggttggc atcacctcgc cgggctttat tggcgcggac     2100

gtttcgcacc tcaacctgca taaaactttc tgcattccgc acggcggtgg tggtccgggt     2160

atgggaccga tcggtgtgaa agcgcatctg gcaccgtttg taccgggtca tagcgtggtg     2220

caaatcgaag gcatgttaac ccgtcagggc gcagtttctg cggcaccgtt cggtagcgcc     2280

tctatcctgc caatcagctg gatgtacatc cgcatgatgg gcgcagaagg gctgaaaaaa     2340

gcaagccagg tggcaatcct caacgccaac tatattgcca gccgcctgca ggatgccttc     2400

ccggtgctgt ataccggtcg cgacggtcgc gtggcgcacg aatgtattct cgatattcgc     2460

ccgctgaaag aagaaaccgg catcagcgag ctggatattg ccaagcgcct gatcgactac     2520

ggtttccacg cgccgaccat gtcgttcccg gtggcgggta cgctgatggt tgaaccgact     2580

gaatctgaaa gcaaagtgga actggatcgc tttatcgacg cgatgctggc tatccgcgca     2640

gaaatcgacc aggttaaagc cggtgtctgg ccgctggaag ataacccgct ggtgaacgcg     2700

ccgcacattc agaacgaact ggtcgccgag tgggcgcatc cgtacagccg tgaagttgca     2760

gtattcccgg caggtgtggc agacaaatac tggccgacgg tgaaacgtct ggatgatgtt     2820

tacggcgacc gtaacctgtt ctgctcctgc gtaccgatta gcgaatacca gtaa           2874


<210>  50
<211>  957
<212>  PRT
<213>  Escherichia coli

<400>  50

Met Thr Gln Thr Leu Ser Gln Leu Glu Asn Ser Gly Ala Phe Ile Glu 
1               5                   10                  15      


Arg His Ile Gly Pro Asp Ala Ala Gln Gln Gln Glu Met Leu Asn Ala 
            20                  25                  30          


Val Gly Ala Gln Ser Leu Asn Ala Leu Thr Gly Gln Ile Val Pro Lys 
        35                  40                  45              


Asp Ile Gln Leu Ala Thr Pro Pro Gln Val Gly Ala Pro Ala Thr Glu 
    50                  55                  60                  


Tyr Ala Ala Leu Ala Glu Leu Lys Ala Ile Ala Ser Arg Asn Lys Arg 
65                  70                  75                  80  


Phe Thr Ser Tyr Ile Gly Met Gly Tyr Thr Ala Val Gln Leu Pro Pro 
                85                  90                  95      


Val Ile Leu Arg Asn Met Leu Glu Asn Pro Gly Trp Tyr Thr Ala Tyr 
            100                 105                 110         


Thr Pro Tyr Gln Pro Glu Val Ser Gln Gly Arg Leu Glu Ala Leu Leu 
        115                 120                 125             


Asn Phe Gln Gln Val Thr Leu Asp Leu Thr Gly Leu Asp Met Ala Ser 
    130                 135                 140                 


Ala Ser Leu Leu Asp Glu Ala Thr Ala Ala Ala Glu Ala Met Ala Met 
145                 150                 155                 160 


Ala Lys Arg Val Ser Lys Leu Lys Asn Ala Asn Arg Phe Phe Val Ala 
                165                 170                 175     


Ser Asp Val His Pro Gln Thr Leu Asp Val Val Arg Thr Arg Ala Glu 
            180                 185                 190         


Thr Phe Gly Phe Glu Val Ile Val Asp Asp Ala Gln Lys Val Leu Asp 
        195                 200                 205             


His Gln Asp Val Phe Gly Val Leu Leu Gln Gln Val Gly Thr Thr Gly 
    210                 215                 220                 


Glu Ile His Asp Tyr Thr Ala Leu Ile Ser Glu Leu Lys Ser Arg Lys 
225                 230                 235                 240 


Ile Val Val Ser Val Ala Ala Asp Ile Met Ala Leu Val Leu Leu Thr 
                245                 250                 255     


Ala Pro Gly Lys Gln Gly Ala Asp Ile Val Phe Gly Ser Ala Gln Arg 
            260                 265                 270         


Phe Gly Val Pro Met Gly Tyr Gly Gly Pro His Ala Ala Phe Phe Ala 
        275                 280                 285             


Ala Lys Asp Glu Tyr Lys Arg Ser Met Pro Gly Arg Ile Ile Gly Val 
    290                 295                 300                 


Ser Lys Asp Ala Ala Gly Asn Thr Ala Leu Arg Met Ala Met Gln Thr 
305                 310                 315                 320 


Arg Glu Gln His Ile Arg Arg Glu Lys Ala Asn Ser Asn Ile Cys Thr 
                325                 330                 335     


Ser Gln Val Leu Leu Ala Asn Ile Ala Ser Leu Tyr Ala Val Tyr His 
            340                 345                 350         


Gly Pro Ile Gly Leu Lys Arg Ile Ala Asn Arg Ile His Arg Leu Thr 
        355                 360                 365             


Asp Ile Leu Ala Ala Gly Leu Gln Gln Lys Gly Leu Lys Leu Arg His 
    370                 375                 380                 


Ala His Tyr Phe Asp Thr Leu Cys Val Glu Val Ala Asp Lys Ala Gly 
385                 390                 395                 400 


Val Leu Thr Arg Ala Glu Ala Ala Glu Ile Asn Leu Arg Ser Asp Ile 
                405                 410                 415     


Leu Asn Ala Val Gly Ile Thr Leu Asp Glu Thr Thr Thr Arg Glu Asn 
            420                 425                 430         


Val Met Gln Leu Phe Asn Val Leu Leu Gly Asp Asn His Gly Leu Asp 
        435                 440                 445             


Ile Asp Thr Leu Asp Lys Asp Val Ala His Asp Ser Arg Ser Ile Gln 
    450                 455                 460                 


Pro Ala Met Leu Arg Asp Asp Glu Ile Leu Thr His Pro Val Phe Asn 
465                 470                 475                 480 


Arg Tyr His Ser Glu Thr Glu Met Met Arg Tyr Met His Ser Leu Glu 
                485                 490                 495     


Arg Lys Asp Leu Ala Leu Asn Gln Ala Met Ile Pro Leu Gly Ser Cys 
            500                 505                 510         


Thr Met Lys Leu Asn Ala Ala Ala Glu Met Ile Pro Ile Thr Trp Pro 
        515                 520                 525             


Glu Phe Ala Glu Leu His Pro Phe Cys Pro Pro Glu Gln Ala Glu Gly 
    530                 535                 540                 


Tyr Gln Gln Met Ile Ala Gln Leu Ala Asp Trp Leu Val Lys Leu Thr 
545                 550                 555                 560 


Gly Tyr Asp Ala Val Cys Met Gln Pro Asn Ser Gly Ala Gln Gly Glu 
                565                 570                 575     


Tyr Ala Gly Leu Leu Ala Ile Arg His Tyr His Glu Ser Arg Asn Glu 
            580                 585                 590         


Gly His Arg Asp Ile Cys Leu Ile Pro Ala Ser Ala His Gly Thr Asn 
        595                 600                 605             


Pro Ala Ser Ala His Met Ala Gly Met Gln Val Val Val Val Ala Cys 
    610                 615                 620                 


Asp Lys Asn Gly Asn Ile Asp Leu Thr Asp Leu Arg Ala Lys Ala Glu 
625                 630                 635                 640 


Gln Ala Gly Asp Asn Leu Ser Cys Ile Met Val Thr Tyr Pro Ser Thr 
                645                 650                 655     


His Gly Val Tyr Glu Glu Thr Ile Arg Glu Val Cys Glu Val Val His 
            660                 665                 670         


Gln Phe Gly Gly Gln Val Tyr Leu Asp Gly Ala Asn Met Asn Ala Gln 
        675                 680                 685             


Val Gly Ile Thr Ser Pro Gly Phe Ile Gly Ala Asp Val Ser His Leu 
    690                 695                 700                 


Asn Leu His Lys Thr Phe Cys Ile Pro His Gly Gly Gly Gly Pro Gly 
705                 710                 715                 720 


Met Gly Pro Ile Gly Val Lys Ala His Leu Ala Pro Phe Val Pro Gly 
                725                 730                 735     


His Ser Val Val Gln Ile Glu Gly Met Leu Thr Arg Gln Gly Ala Val 
            740                 745                 750         


Ser Ala Ala Pro Phe Gly Ser Ala Ser Ile Leu Pro Ile Ser Trp Met 
        755                 760                 765             


Tyr Ile Arg Met Met Gly Ala Glu Gly Leu Lys Lys Ala Ser Gln Val 
    770                 775                 780                 


Ala Ile Leu Asn Ala Asn Tyr Ile Ala Ser Arg Leu Gln Asp Ala Phe 
785                 790                 795                 800 


Pro Val Leu Tyr Thr Gly Arg Asp Gly Arg Val Ala His Glu Cys Ile 
                805                 810                 815     


Leu Asp Ile Arg Pro Leu Lys Glu Glu Thr Gly Ile Ser Glu Leu Asp 
            820                 825                 830         


Ile Ala Lys Arg Leu Ile Asp Tyr Gly Phe His Ala Pro Thr Met Ser 
        835                 840                 845             


Phe Pro Val Ala Gly Thr Leu Met Val Glu Pro Thr Glu Ser Glu Ser 
    850                 855                 860                 


Lys Val Glu Leu Asp Arg Phe Ile Asp Ala Met Leu Ala Ile Arg Ala 
865                 870                 875                 880 


Glu Ile Asp Gln Val Lys Ala Gly Val Trp Pro Leu Glu Asp Asn Pro 
                885                 890                 895     


Leu Val Asn Ala Pro His Ile Gln Asn Glu Leu Val Ala Glu Trp Ala 
            900                 905                 910         


His Pro Tyr Ser Arg Glu Val Ala Val Phe Pro Ala Gly Val Ala Asp 
        915                 920                 925             


Lys Tyr Trp Pro Thr Val Lys Arg Leu Asp Asp Val Tyr Gly Asp Arg 
    930                 935                 940                 


Asn Leu Phe Cys Ser Cys Val Pro Ile Ser Glu Tyr Gln 
945                 950                 955         


<210>  51
<211>  4543
<212>  DNA
<213>  Escherichia coli

<400>  51
atatacatat ggcacaacag actcctttgt acgaacaaca cacgctttgc ggcgctcgca       60

tggtggattt ccacggctgg atgatgccgc tgcattacgg ttcgcaaatc gacgaacatc      120

atgcggtacg taccgatgcc ggaatgtttg atgtgtcaca tatgaccatc gtcgatctcc      180

gcggcagccg cacccgggag tttctgcgtt atctgctggc gaacgatgtg gcgaagctca      240

ccaaaagcgg caaagccctt tactcgggga tgttgaatgc ctctggcggt gtgatagatg      300

acctcatcgt ctactacttt actgaagatt tcttccgcct cgttgttaac tccgccaccc      360

gcgaaaaaga cctctcctgg attacccaac acgctgaacc tttcggcatc gaaattaccg      420

ttcgtgatga cctttccatg attgccgtgc aagggccgaa tgcgcaggca aaagctgcca      480

cactgtttaa tgacgcccag cgtcaggcgg tggaagggat gaaaccgttc tttggcgtgc      540

aggcgggcga tctgtttatt gccaccactg gttataccgg tgaagcgggc tatgaaattg      600

cgctgcccaa tgaaaaagcg gccgatttct ggcgtgcgct ggtggaagcg ggtgttaagc      660

catgtggctt gggcgcgcgt gacacgctgc gtctggaagc gggcatgaat ctttatggtc      720

aggagatgga cgaaactatt tctcctttag ccgccaacat gggctggact atcgcctggg      780

aaccggcaga tcgtgacttt atcggtcgtg aagccctgga agtgcagcgt gagcatggta      840

cagaaaaact ggttggtctg gtgatgaccg aaaaaggcgt gctgcgtaat gaactgccgg      900

tacgctttac cgatgcgcag ggcaaccagc atgaaggcat tatcaccagc ggtactttct      960

ccccgacgct gggttacagc attgcgctgg cgcgcgtgcc ggaaggtatt ggcgaaacgg     1020

cgattgtgca aattcgcaac cgtgaaatgc cggttaaagt gacaaaacct gtttttgtgc     1080

gtaacggcaa agccgtcgcg tgatttactt ttttggagat tgattgatga gcaacgtacc     1140

agcagaactg aaatacagca aagaacacga atggctgcgt aaagaagccg acggcactta     1200

caccgttggt attaccgaac atgctcagga gctgttaggc gatatggtgt ttgttgacct     1260

gccggaagtg ggcgcaacgg ttagcgcggg cgatgactgc gcggttgccg aatcagtaaa     1320

agcggcgtca gacatttatg cgccagtaag cggtgaaatc gtggcggtaa acgacgcact     1380

gagcgattcc ccggaactgg tgaacagcga accgtatgca ggtggctgga tctttaaaat     1440

caaagccagc gatgaaagcg aactggaatc actgctggat gcgaccgcat acgaagcatt     1500

gttagaagac gagtaacggc tttattcctc ttctgcggga gaggatcagg gtgaggaaaa     1560

tttatgcctc accctcactc tcttcgtaag gagagaggtt cacaattcac tgcacgtttc     1620

aggaaccatc gctcatgaca cagacgttaa gccagcttga aaacagcggc gcttttattg     1680

aacgccatat cggaccggac gccgcgcaac agcaagaaat gctgaatgcc gttggtgcac     1740

aatcgttaaa cgcgctgacc ggccagattg tgccgaaaga tattcagctt gcgaccccgc     1800

cgcaggttgg cgcaccggcg accgaatacg ccgcactggc agaactcaag gctattgcca     1860

gtcgcaataa acgcttcacg tcttacatcg gcatgggtta caccgccgtg cagctaccgc     1920

cggttatcct gcgtaacatg ctggaaaatc cgggctggta taccgcgtac actccgtatc     1980

aacctgaagt ctcccagggc cgccttgaag cactgctcaa cttccagcag gtaacgctgg     2040

atttgactgg actggatatg gcctctgctt ctcttctgga cgaggccacc gctgccgccg     2100

aagcaatggc gatggcgaaa cgcgtcagca aactgaaaaa tgccaaccgc ttcttcgtgg     2160

cttccgatgt gcatccgcaa acgctggatg tggtccgtac tcgtgccgaa acctttggtt     2220

ttgaagtgat tgtcgatgac gcgcaaaaag tgctcgacca tcaggacgtc ttcggcgtgc     2280

tgttacagca ggttggcaca accggtgaaa tccacgacta caccgcgctt attagcgaac     2340

tgaaatcacg caaaattgtg gtcagcgttg ccgccgatat tatggcgctg gtgctgttaa     2400

ctgcgccggg taaacagggc gcggatattg tttttggttc ggcgcaacgc ttcggcgtgc     2460

cgatgggcta cggtggccca cacgcggcat tctttgcggc gaaagatgaa tacaaacgct     2520

caatgccggg ccgtattatc ggtgtatcga aagatgcagc tggcaatacc gcgctgcgca     2580

tggcgatgca gactcgcgag caacatatcc gccgtgagaa agcgaactcc aacatttgta     2640

cttcccaggt actgctggca aacatcgcca gcctgtatgc cgtttatcac ggcccgattg     2700

gcctgaaacg tatcgctaac cgcattcacc gtttgaccga tatcctggcg gcaggcctgc     2760

aacaaaaagg tctgaagctg cgccatgcgc actatttcga caccttgtgt gtggaagtgg     2820

ccgacaaagc gggcgtactg acgcgtgccg aagcggctga aatcaacctg cgtagcgata     2880

ttctgaacgc ggttgggatc acccttgatg aaacaaccac gcgtgaaaac gtaatgcagc     2940

ttttcaacgt gctgctgggc gataaccacg gcctggacat cgacacgctg gacaaagacg     3000

tggctcacga cagccgctct atccagcctg cgatgctgcg cgacgacgaa atcctcaccc     3060

atccggtgtt taatcgctac cacagcgaaa ccgaaatgat gcgctatatg cactcgctgg     3120

agcgtaaaga tctggcgctg aatcaggcga tgatcccgct gggttcctgc accatgaaac     3180

tgaacgccgc cgccgagatg atcccaatca cctggccgga atttgccgaa ctgcacccgt     3240

tttgtccgcc ggaacaggct gaaggttatc agcagatgat tgcgcagctg gctgactggc     3300

tggtgaaact gaccggttac gacgccgttt gtatgcagcc gaactccggc gcacagggcg     3360

aatacgcggg cctgctggcg attcgtcatt atcatgaaag ccgcaacgaa gggcatcgcg     3420

atatctgcct gatcccggct tctgcgcacg gaactaaccc cgcttctgca catatggcag     3480

gaatgcaggt ggtggttgtg gcgtgtgata aaaacggcaa catcgatctg actgatctgc     3540

gcgcgaaagc ggaacaggcg ggcgataacc tctcctgtat catggtgact tatccttcta     3600

cccacggcgt gtatgaagaa acgatccgtg aagtgtgtga agtcgtgcat cagttcggcg     3660

gtcaggttta ccttgatggc gcgaacatga acgcccaggt tggcatcacc tcgccgggct     3720

ttattggcgc ggacgtttcg cacctcaacc tgcataaaac tttctgcatt ccgcacggcg     3780

gtggtggtcc gggtatggga ccgatcggtg tgaaagcgca tctggcaccg tttgtaccgg     3840

gtcatagcgt ggtgcaaatc gaaggcatgt taacccgtca gggcgcagtt tctgcggcac     3900

cgttcggtag cgcctctatc ctgccaatca gctggatgta catccgcatg atgggcgcag     3960

aagggctgaa aaaagcaagc caggtggcaa tcctcaacgc caactatatt gccagccgcc     4020

tgcaggatgc cttcccggtg ctgtataccg gtcgcgacgg tcgcgtggcg cacgaatgta     4080

ttctcgatat tcgcccgctg aaagaagaaa ccggcatcag cgagctggat attgccaagc     4140

gcctgatcga ctacggtttc cacgcgccga ccatgtcgtt cccggtggcg ggtacgctga     4200

tggttgaacc gactgaatct gaaagcaaag tggaactgga tcgctttatc gacgcgatgc     4260

tggctatccg cgcagaaatc gaccaggtta aagccggtgt ctggccgctg gaagataacc     4320

cgctggtgaa cgcgccgcac attcagaacg aactggtcgc cgagtgggcg catccgtaca     4380

gccgtgaagt tgcagtattc ccggcaggtg tggcagacaa atactggccg acggtgaaac     4440

gtctggatga tgtttacggc gaccgtaacc tgttctgctc ctgcgtaccg attagcgaat     4500

accagtaatt cactgattcg actatcttct aaaggcgctt cgg                       4543

<210>  52
<211>  8433
<212>  DNA
<213>  Artificial

<220>
<223>  Vector

<400>  52

cgataagctt cgactgcacg gtgcaccaat gcttctggcg tcaggcagcc atcggaagct       60

gtggtatggc tgtgcaggtc gtaaatcact gcataattcg tgtcgctcaa ggcgcactcc      120

cgttctggat aatgtttttt gcgccgacat cataacggtt ctggcaaata ttctgaaatg      180

agctgttgac aattaatcat ccggctcgta taatgtgtgg aattgtgagc ggataacaat      240

ttcagaattc aaaagatctt ttaagaagga gatatacata tggcacaaca gactcctttg      300

tacgaacaac acacgctttg cggcgctcgc atggtggatt tccacggctg gatgatgccg      360

ctgcattacg gttcgcaaat cgacgaacat catgcggtac gtaccgatgc cggaatgttt      420

gatgtgtcac atatgaccat cgtcgatctc cgcggcagcc gcacccggga gtttctgcgt      480

tatctgctgg cgaacgatgt ggcgaagctc accaaaagcg gcaaagccct ttactcgggg      540

atgttgaatg cctctggcgg tgtgatagat gacctcatcg tctactactt tactgaagat      600

ttcttccgcc tcgttgttaa ctccgccacc cgcgaaaaag acctctcctg gattacccaa      660

cacgctgaac ctttcggcat cgaaattacc gttcgtgatg acctttccat gattgccgtg      720

caagggccga atgcgcaggc aaaagctgcc acactgttta atgacgccca gcgtcaggcg      780

gtggaaggga tgaaaccgtt ctttggcgtg caggcgggcg atctgtttat tgccaccact      840

ggttataccg gtgaagcggg ctatgaaatt gcgctgccca atgaaaaagc ggccgatttc      900

tggcgtgcgc tggtggaagc gggtgttaag ccatgtggct tgggcgcgcg tgacacgctg      960

cgtctggaag cgggcatgaa tctttatggt caggagatgg acgaaactat ttctccttta     1020

gccgccaaca tgggctggac tatcgcctgg gaaccggcag atcgtgactt tatcggtcgt     1080

gaagccctgg aagtgcagcg tgagcatggt acagaaaaac tggttggtct ggtgatgacc     1140

gaaaaaggcg tgctgcgtaa tgaactgccg gtacgcttta ccgatgcgca gggcaaccag     1200

catgaaggca ttatcaccag cggtactttc tccccgacgc tgggttacag cattgcgctg     1260

gcgcgcgtgc cggaaggtat tggcgaaacg gcgattgtgc aaattcgcaa ccgtgaaatg     1320

ccggttaaag tgacaaaacc tgtttttgtg cgtaacggca aagccgtcgc gtgatttact     1380

tttttggaga ttgattgatg agcaacgtac cagcagaact gaaatacagc aaagaacacg     1440

aatggctgcg taaagaagcc gacggcactt acaccgttgg tattaccgaa catgctcagg     1500

agctgttagg cgatatggtg tttgttgacc tgccggaagt gggcgcaacg gttagcgcgg     1560

gcgatgactg cgcggttgcc gaatcagtaa aagcggcgtc agacatttat gcgccagtaa     1620

gcggtgaaat cgtggcggta aacgacgcac tgagcgattc cccggaactg gtgaacagcg     1680

aaccgtatgc aggtggctgg atctttaaaa tcaaagccag cgatgaaagc gaactggaat     1740

cactgctgga tgcgaccgca tacgaagcat tgttagaaga cgagtaacgg ctttattcct     1800

cttctgcggg agaggatcag ggtgaggaaa atttatgcct caccctcact ctcttcgtaa     1860

ggagagaggt tcacaattca ctgcacgttt caggaaccat cgctcatgac acagacgtta     1920

agccagcttg aaaacagcgg cgcttttatt gaacgccata tcggaccgga cgccgcgcaa     1980

cagcaagaaa tgctgaatgc cgttggtgca caatcgttaa acgcgctgac cggccagatt     2040

gtgccgaaag atattcagct tgcgaccccg ccgcaggttg gcgcaccggc gaccgaatac     2100

gccgcactgg cagaactcaa ggctattgcc agtcgcaata aacgcttcac gtcttacatc     2160

ggcatgggtt acaccgccgt gcagctaccg ccggttatcc tgcgtaacat gctggaaaat     2220

ccgggctggt ataccgcgta cactccgtat caacctgaag tctcccaggg ccgccttgaa     2280

gcactgctca acttccagca ggtaacgctg gatttgactg gactggatat ggcctctgct     2340

tctcttctgg acgaggccac cgctgccgcc gaagcaatgg cgatggcgaa acgcgtcagc     2400

aaactgaaaa atgccaaccg cttcttcgtg gcttccgatg tgcatccgca aacgctggat     2460

gtggtccgta ctcgtgccga aacctttggt tttgaagtga ttgtcgatga cgcgcaaaaa     2520

gtgctcgacc atcaggacgt cttcggcgtg ctgttacagc aggttggcac aaccggtgaa     2580

atccacgact acaccgcgct tattagcgaa ctgaaatcac gcaaaattgt ggtcagcgtt     2640

gccgccgata ttatggcgct ggtgctgtta actgcgccgg gtaaacaggg cgcggatatt     2700

gtttttggtt cggcgcaacg cttcggcgtg ccgatgggct acggtggccc acacgcggca     2760

ttctttgcgg cgaaagatga atacaaacgc tcaatgccgg gccgtattat cggtgtatcg     2820

aaagatgcag ctggcaatac cgcgctgcgc atggcgatgc agactcgcga gcaacatatc     2880

cgccgtgaga aagcgaactc caacatttgt acttcccagg tactgctggc aaacatcgcc     2940

agcctgtatg ccgtttatca cggcccgatt ggcctgaaac gtatcgctaa ccgcattcac     3000

cgtttgaccg atatcctggc ggcaggcctg caacaaaaag gtctgaagct gcgccatgcg     3060

cactatttcg acaccttgtg tgtggaagtg gccgacaaag cgggcgtact gacgcgtgcc     3120

gaagcggctg aaatcaacct gcgtagcgat attctgaacg cggttgggat cacccttgat     3180

gaaacaacca cgcgtgaaaa cgtaatgcag cttttcaacg tgctgctggg cgataaccac     3240

ggcctggaca tcgacacgct ggacaaagac gtggctcacg acagccgctc tatccagcct     3300

gcgatgctgc gcgacgacga aatcctcacc catccggtgt ttaatcgcta ccacagcgaa     3360

accgaaatga tgcgctatat gcactcgctg gagcgtaaag atctggcgct gaatcaggcg     3420

atgatcccgc tgggttcctg caccatgaaa ctgaacgccg ccgccgagat gatcccaatc     3480

acctggccgg aatttgccga actgcacccg ttttgtccgc cggaacaggc tgaaggttat     3540

cagcagatga ttgcgcagct ggctgactgg ctggtgaaac tgaccggtta cgacgccgtt     3600

tgtatgcagc cgaactccgg cgcacagggc gaatacgcgg gcctgctggc gattcgtcat     3660

tatcatgaaa gccgcaacga agggcatcgc gatatctgcc tgatcccggc ttctgcgcac     3720

ggaactaacc ccgcttctgc acatatggca ggaatgcagg tggtggttgt ggcgtgtgat     3780

aaaaacggca acatcgatct gactgatctg cgcgcgaaag cggaacaggc gggcgataac     3840

ctctcctgta tcatggtgac ttatccttct acccacggcg tgtatgaaga aacgatccgt     3900

gaagtgtgtg aagtcgtgca tcagttcggc ggtcaggttt accttgatgg cgcgaacatg     3960

aacgcccagg ttggcatcac ctcgccgggc tttattggcg cggacgtttc gcacctcaac     4020

ctgcataaaa ctttctgcat tccgcacggc ggtggtggtc cgggtatggg accgatcggt     4080

gtgaaagcgc atctggcacc gtttgtaccg ggtcatagcg tggtgcaaat cgaaggcatg     4140

ttaacccgtc agggcgcagt ttctgcggca ccgttcggta gcgcctctat cctgccaatc     4200

agctggatgt acatccgcat gatgggcgca gaagggctga aaaaagcaag ccaggtggca     4260

atcctcaacg ccaactatat tgccagccgc ctgcaggatg ccttcccggt gctgtatacc     4320

ggtcgcgacg gtcgcgtggc gcacgaatgt attctcgata ttcgcccgct gaaagaagaa     4380

accggcatca gcgagctgga tattgccaag cgcctgatcg actacggttt ccacgcgccg     4440

accatgtcgt tcccggtggc gggtacgctg atggttgaac cgactgaatc tgaaagcaaa     4500

gtggaactgg atcgctttat cgacgcgatg ctggctatcc gcgcagaaat cgaccaggtt     4560

aaagccggtg tctggccgct ggaagataac ccgctggtga acgcgccgca cattcagaac     4620

gaactggtcg ccgagtgggc gcatccgtac agccgtgaag ttgcagtatt cccggcaggt     4680

gtggcagaca aatactggcc gacggtgaaa cgtctggatg atgtttacgg cgaccgtaac     4740

ctgttctgct cctgcgtacc gattagcgaa taccagtaat tcactgattc gactatcttc     4800

taaaggcgct tcgggtcgac cgatgccctt gagagccttc aacccagtca gctccttccg     4860

gtgggcgcgg ggcatgacta tcgtcgccgc acttatgact gtcttcttta tcatgcaact     4920

cgtaggacag gtgccggcag cgctctgggt cattttcggc gaggaccgct ttcgctggag     4980

cgcgacgatg atcggcctgt cgcttgcggt attcggaatc ttgcacgccc tcgctcaagc     5040

cttcgtcact ggtcccgcca ccaaacgttt cggcgagaag caggccatta tcgccggcat     5100

ggcggccgac gcgctgggct acgtcttgct ggcgttcgcg acgcgaggct ggatggcctt     5160

ccccattatg attcttctcg cttccggcgg catcgggatg cccgcgttgc aggccatgct     5220

gtccaggcag gtagatgacg accatcaggg acagcttcaa ggatcgctcg cggctcttac     5280

cagcctaact tcgatcactg gaccgctgat cgtcacggcg atttatgccg cctcggcgag     5340

cacatggaac gggttggcat ggattgtagg cgccgcccta taccttgtct gcctccccgc     5400

gttgcgtcgc ggtgcatgga gccgggccac ctcgacctga atggaagccg gcggcacctc     5460

gctaacggat tcaccactcc aagaattgga gccaatcaat tcttgcggag aactgtgaat     5520

gcgcaaacca acccttggca gaacatatcc atcgcgtccg ccatctccag cagccgcacg     5580

cggcgcatct cgggcagcgt tgggtcctgg ccacgggtgc gcatgatcgt gctcctgtcg     5640

ttgaggaccc ggctaggctg gcggggttgc cttactggtt agcagaatga atcaccgata     5700

cgcgagcgaa cgtgaagcga ctgctgctgc aaaacgtctg cgacctgagc aacaacatga     5760

atggtcttcg gtttccgtgt ttcgtaaagt ctggaaacgc ggaagtcccc tacgtgctgc     5820

tgaagttgcc cgcaacagag agtggaacca accggtgata ccacgatact atgactgaga     5880

gtcaacgcca tgagcggcct catttcttat tctgagttac aacagtccgc accgctgtcc     5940

ggtagctcct tccggtgggc gcggggcatg actatcgtcg ccgcacttat gactgtcttc     6000

tttatcatgc aactcgtagg acaggtgccg gcagcgccca acagtccccc ggccacgggg     6060

cctgccacca tacccacgcc gaaacaagcg ccctgcacca ttatgttccg gatctgcatc     6120

gcaggatgct gctggctacc ctgtggaaca cctacatctg tattaacgaa gcgctaaccg     6180

tttttatcag gctctgggag gcagaataaa tgatcatatc gtcaattatt acctccacgg     6240

ggagagcctg agcaaactgg cctcaggcat ttgagaagca cacggtcaca ctgcttccgg     6300

tagtcaataa accggtaaac cagcaataga cataagcggc tatttaacga ccctgccctg     6360

aaccgacgac cgggtcgaat ttgctttcga atttctgcca ttcatccgct tattatcact     6420

tattcaggcg tagcaccagg cgtttaaggg caccaataac tgccttaaaa aaattacgcc     6480

ccgccctgcc actcatcgca gtactgttgt aattcattaa gcattctgcc gacatggaag     6540

ccatcacaga cggcatgatg aacctgaatc gccagcggca tcagcacctt gtcgccttgc     6600

gtataatatt tgcccatggt gaaaacgggg gcgaagaagt tgtccatatt ggccacgttt     6660

aaatcaaaac tggtgaaact cacccaggga ttggctgaga cgaaaaacat attctcaata     6720

aaccctttag ggaaataggc caggttttca ccgtaacacg ccacatcttg cgaatatatg     6780

tgtagaaact gccggaaatc gtcgtggtat tcactccaga gcgatgaaaa cgtttcagtt     6840

tgctcatgga aaacggtgta acaagggtga acactatccc atatcaccag ctcaccgtct     6900

ttcattgcca tacggaattc cggatgagca ttcatcaggc gggcaagaat gtgaataaag     6960

gccggataaa acttgtgctt atttttcttt acggtcttta aaaaggccgt aatatccagc     7020

tgaacggtct ggttataggt acattgagca actgactgaa atgcctcaaa atgttcttta     7080

cgatgccatt gggatatatc aacggtggta tatccagtga tttttttctc cattttagct     7140

tccttagctc ctgaaaatct cgataactca aaaaatacgc ccggtagtga tcttatttca     7200

ttatggtgaa agttggaacc tcttacgtgc cgatcaacgt ctcattttcg ccaaaagttg     7260

gcccagggct tcccggtatc aacagggaca ccaggattta tttattctgc gaagtgatct     7320

tccgtcacag gtatttattc ggcgcaaagt gcgtcgggtg atgctgccaa cttactgatt     7380

tagtgtatga tggtgttttt gaggtgctcc agtggcttct gtttctatca gctgtccctc     7440

ctgttcagct actgacgggg tggtgcgtaa cggcaaaagc accgccggac atcagcgcta     7500

gcggagtgta tactggctta ctatgttggc actgatgagg gtgtcagtga agtgcttcat     7560

gtggcaggag aaaaaaggct gcaccggtgc gtcagcagaa tatgtgatac aggatatatt     7620

ccgcttcctc gctcactgac tcgctacgct cggtcgttcg actgcggcga gcggaaatgg     7680

cttacgaacg gggcggagat ttcctggaag atgccaggaa gatacttaac agggaagtga     7740

gagggccgcg gcaaagccgt ttttccatag gctccgcccc cctgacaagc atcacgaaat     7800

ctgacgctca aatcagtggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc     7860

ccctggcggc tccctcgtgc gctctcctgt tcctgccttt cggtttaccg gtgtcattcc     7920

gctgttatgg ccgcgtttgt ctcattccac gcctgacact cagttccggg taggcagttc     7980

gctccaagct ggactgtatg cacgaacccc ccgttcagtc cgaccgctgc gccttatccg     8040

gtaactatcg tcttgagtcc aacccggaaa gacatgcaaa agcaccactg gcagcagcca     8100

ctggtaattg atttagagga gttagtcttg aagtcatgcg ccggttaagg ctaaactgaa     8160

aggacaagtt ttggtgactg cgctcctcca agccagttac ctcggttcaa agagttggta     8220

gctcagagaa ccttcgaaaa accgccctgc aaggcggttt tttcgttttc agagcaagag     8280

attacgcgca gaccaaaacg atctcaagaa gatcatctta ttaatcagat aaaatatttc     8340

tagatttcag tgcaatttat ctcttcaaat gtagcacctg aagtcagccc catacgatat     8400

aagttgtaat tctcatgttt gacagcttat cat                                  8433



<210>  53
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  53
gaaggagata tacatatggc acaacagact ccttt                                  35


<210>  54
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Primer

<400>  54
aagggcatcg gtcgacccga agcgccttta gaagat                                 36


<210>  55
<211>  285
<212>  DNA
<213>  Artificial

<220>
<223>  Promoter

<400>  55
tatcatcgat aagcttcgac tgcacggtgc accaatgctt ctggcgtcag gcagccatcg       60

gaagctgtgg tatggctgtg caggtcgtaa atcactgcat aattcgtgtc gctcaaggcg      120

cactcccgtt ctggataatg ttttttgcgc cgacatcata acggttctgg caaatattct      180

gaaatgagct gttgacaatt aatcatccgg ctcgtataat gtgtggaatt gtgagcggat      240

aacaatttca gaattcaaaa gatcttttaa gaaggagata tacat                      285

<210>  56
<211>  3898
<212>  DNA
<213>  Artificial

<220>
<223>  Vector

<400>  56
gaattccgga tgagcattca tcaggcgggc aagaatgtga ataaaggccg gataaaactt       60

gtgcttattt ttctttacgg tctttaaaaa ggccgtaata tccagctgaa cggtctggtt      120

ataggtacat tgagcaactg actgaaatgc ctcaaaatgt tctttacgat gccattggga      180

tatatcaacg gtggtatatc cagtgatttt tttctccatt ttagcttcct tagctcctga      240

aaatctcgat aactcaaaaa atacgcccgg tagtgatctt atttcattat ggtgaaagtt      300

ggaacctctt acgtgccgat caacgtctca ttttcgccaa aagttggccc agggcttccc      360

ggtatcaaca gggacaccag gatttattta ttctgcgaag tgatcttccg tcacaggtat      420

ttattcggcg caaagtgcgt cgggtgatgc tgccaactta ctgatttagt gtatgatggt      480

gtttttgagg tgctccagtg gcttctgttt ctatcagctg tccctcctgt tcagctactg      540

acggggtggt gcgtaacggc aaaagcaccg ccggacatca gcgctagcgg agtgtatact      600

ggcttactat gttggcactg atgagggtgt cagtgaagtg cttcatgtgg caggagaaaa      660

aaggctgcac cggtgcgtca gcagaatatg tgatacagga tatattccgc ttcctcgctc      720

actgactcgc tacgctcggt cgttcgactg cggcgagcgg aaatggctta cgaacggggc      780

ggagatttcc tggaagatgc caggaagata cttaacaggg aagtgagagg gccgcggcaa      840

agccgttttt ccataggctc cgcccccctg acaagcatca cgaaatctga cgctcaaatc      900

agtggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggcggctccc      960

tcgtgcgctc tcctgttcct gcctttcggt ttaccggtgt cattccgctg ttatggccgc     1020

gtttgtctca ttccacgcct gacactcagt tccgggtagg cagttcgctc caagctggac     1080

tgtatgcacg aaccccccgt tcagtccgac cgctgcgcct tatccggtaa ctatcgtctt     1140

gagtccaacc cggaaagaca tgcaaaagca ccactggcag cagccactgg taattgattt     1200

agaggagtta gtcttgaagt catgcgccgg ttaaggctaa actgaaagga caagttttgg     1260

tgactgcgct cctccaagcc agttacctcg gttcaaagag ttggtagctc agagaacctt     1320

cgaaaaaccg ccctgcaagg cggttttttc gttttcagag caagagatta cgcgcagacc     1380

aaaacgatct caagaagatc atcttattaa tcagataaaa tatttctaga tttcagtgca     1440

atttatctct tcaaatgtag cacctgaagt cagccccata cgatataagt tgtaattctc     1500

atgtttgaca gcttatcatc gataagcttc gactgcacgg tgcaccaatg cttctggcgt     1560

caggcagcca tcggaagctg tggtatggct gtgcaggtcg taaatcactg cataattcgt     1620

gtcgctcaag gcgcactccc gttctggata atgttttttg cgccgacatc ataacggttc     1680

tggcaaatat tctgaaatga gctgttgaca attaatcatc cggctcgtat aatgtgtgga     1740

attgtgagcg gataacaatt tcagaattca aaagatcttt taagaaggag atatacatgt     1800

cgaccgatgc ccttgagagc cttcaaccca gtcagctcct tccggtgggc gcggggcatg     1860

actatcgtcg ccgcacttat gactgtcttc tttatcatgc aactcgtagg acaggtgccg     1920

gcagcgctct gggtcatttt cggcgaggac cgctttcgct ggagcgcgac gatgatcggc     1980

ctgtcgcttg cggtattcgg aatcttgcac gccctcgctc aagccttcgt cactggtccc     2040

gccaccaaac gtttcggcga gaagcaggcc attatcgccg gcatggcggc cgacgcgctg     2100

ggctacgtct tgctggcgtt cgcgacgcga ggctggatgg ccttccccat tatgattctt     2160

ctcgcttccg gcggcatcgg gatgcccgcg ttgcaggcca tgctgtccag gcaggtagat     2220

gacgaccatc agggacagct tcaaggatcg ctcgcggctc ttaccagcct aacttcgatc     2280

actggaccgc tgatcgtcac ggcgatttat gccgcctcgg cgagcacatg gaacgggttg     2340

gcatggattg taggcgccgc cctatacctt gtctgcctcc ccgcgttgcg tcgcggtgca     2400

tggagccggg ccacctcgac ctgaatggaa gccggcggca cctcgctaac ggattcacca     2460

ctccaagaat tggagccaat caattcttgc ggagaactgt gaatgcgcaa accaaccctt     2520

ggcagaacat atccatcgcg tccgccatct ccagcagccg cacgcggcgc atctcgggca     2580

gcgttgggtc ctggccacgg gtgcgcatga tcgtgctcct gtcgttgagg acccggctag     2640

gctggcgggg ttgccttact ggttagcaga atgaatcacc gatacgcgag cgaacgtgaa     2700

gcgactgctg ctgcaaaacg tctgcgacct gagcaacaac atgaatggtc ttcggtttcc     2760

gtgtttcgta aagtctggaa acgcggaagt cccctacgtg ctgctgaagt tgcccgcaac     2820

agagagtgga accaaccggt gataccacga tactatgact gagagtcaac gccatgagcg     2880

gcctcatttc ttattctgag ttacaacagt ccgcaccgct gtccggtagc tccttccggt     2940

gggcgcgggg catgactatc gtcgccgcac ttatgactgt cttctttatc atgcaactcg     3000

taggacaggt gccggcagcg cccaacagtc ccccggccac ggggcctgcc accataccca     3060

cgccgaaaca agcgccctgc accattatgt tccggatctg catcgcagga tgctgctggc     3120

taccctgtgg aacacctaca tctgtattaa cgaagcgcta accgttttta tcaggctctg     3180

ggaggcagaa taaatgatca tatcgtcaat tattacctcc acggggagag cctgagcaaa     3240

ctggcctcag gcatttgaga agcacacggt cacactgctt ccggtagtca ataaaccggt     3300

aaaccagcaa tagacataag cggctattta acgaccctgc cctgaaccga cgaccgggtc     3360

gaatttgctt tcgaatttct gccattcatc cgcttattat cacttattca ggcgtagcac     3420

caggcgttta agggcaccaa taactgcctt aaaaaaatta cgccccgccc tgccactcat     3480

cgcagtactg ttgtaattca ttaagcattc tgccgacatg gaagccatca cagacggcat     3540

gatgaacctg aatcgccagc ggcatcagca ccttgtcgcc ttgcgtataa tatttgccca     3600

tggtgaaaac gggggcgaag aagttgtcca tattggccac gtttaaatca aaactggtga     3660

aactcaccca gggattggct gagacgaaaa acatattctc aataaaccct ttagggaaat     3720

aggccaggtt ttcaccgtaa cacgccacat cttgcgaata tatgtgtaga aactgccgga     3780

aatcgtcgtg gtattcactc cagagcgatg aaaacgtttc agtttgctca tggaaaacgg     3840

tgtaacaagg gtgaacacta tcccatatca ccagctcacc gtctttcatt gccatacg       3898



