               SEQUENCE LISTING

<110> Max-Delbrueck-Centrum fuer Moleculare Medizin

<120> Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO

<130> MDC15875EP

<160> 112

<170> BiSSAP 1.3

<210> 1
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3598 alpha chain CDR3

<400> 1
Cys Ala Met Arg Gln Gly Gly Ser Glu Lys Leu Val Phe 
1               5                   10              

<210> 2
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3598_2 alpha chain CDR3

<400> 2
Cys Ala Leu Arg Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe 
1               5                   10                  15  

<210> 3
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412 alpha chain CDR3

<400> 3
Cys Ala Val Thr Leu Asn Arg Asp Asp Lys Ile Ile Phe 
1               5                   10              

<210> 4
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412_2 alpha chain CDR3

<400> 4
Cys Ala Val Thr Arg Asn Ser Gly Asn Thr Pro Leu Val Phe 
1               5                   10                  

<210> 5
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412_3

<400> 5
Cys Ala Gly Gln Gln Asn Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe 
1               5                   10                  15      



<210> 6
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3600 alpha chain CDR3

<400> 6
Cys Ala Val Pro Asn Ser Gly Asn Thr Pro Leu Val Phe 
1               5                   10              

<210> 7
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5712 alpha chain CDR3

<400> 7
Cys Ala Val Pro Asn Ser Gly Asn Thr Pro Leu Val Phe 
1               5                   10              

<210> 8
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5415 alpha chain CDR3

<400> 8
Cys Ala Val Pro Asn Ser Gly Asn Thr Pro Leu Val Phe 
1               5                   10              

<210> 9
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5713 alpha chain CDR3

<400> 9
Cys Ala Glu Ala Asn Gln Ala Gly Thr Ala Leu Ile Phe 
1               5                   10              

<210> 10
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3598 beta chain CDR3

<400> 10
Cys Ala Ser Ser Gly Gln Gly Ala Gly Thr Gln Tyr Phe 
1               5                   10              

<210> 11
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3598_2 beta chain CDR3

<400> 11
Cys Ala Ser Ser Val Met Thr Gly Leu Asn Thr Glu Ala Phe Phe 
1               5                   10                  15  

<210> 12
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412 beta chain CDR3

<400> 12
Cys Ala Ser Ser Leu Asp Arg Pro Tyr Asn Glu Gln Phe Phe 
1               5                   10                  

<210> 13
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412_2 beta chain CDR3

<400> 13
Cys Ala Ser Ser Phe Leu Ala Ser Val Gly Tyr Glu Gln Tyr Phe 
1               5                   10                  15  

<210> 14
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412_3 beta chain CDR3

<400> 14
Cys Ala Ser Ser Pro Pro Leu Gly Glu Gln Tyr Phe 
1               5                   10          

<210> 15
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3600 beta chain CDR3

<400> 15
Cys Ala Ser Ser Val Ile Tyr Glu Gln Tyr Phe 
1               5                   10      

<210> 16
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5712 beta chain CDR3

<400> 16
Cys Ala Ser Ser Ile Ile Tyr Glu Gln Tyr Phe 
1               5                   10      

<210> 17
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5415 beta chain CDR3

<400> 17
Cys Ala Ser Ser Val Tyr Tyr Glu Gln Tyr Phe 
1               5                   10      

<210> 18
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5713 beta chain CDR3

<400> 18
Cys Ala Ser Ser Gly Leu Ala Gly Val Thr Gly Glu Leu Phe Phe 
1               5                   10                  15  

<210> 19
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-A2 restricted TCR-ESO alpha chain CDR3

<400> 19
Cys Ala Gly Glu Gly Asn Tyr Gly Gln Asn Phe Val Phe 
1               5                   10              

<210> 20
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-A2 restricted TCR-ESO beta chain CDR3

<400> 20
Cys Ala Ser Asn Ile Ala Gly Gly Tyr Asn Glu Gln Phe Phe 
1               5                   10                  

<210> 21
<211> 20
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-DR4 epitope NY-ESO-1 116-135

<400> 21
Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val Ser Gly Asn 
1               5                   10                  15      
Ile Leu Thr Ile 
            20  

<210> 22
<211> 134
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3598 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 22
Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      
Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          
Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              
Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  
Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  
Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      
Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         
Met Arg Gln Gly Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys 
        115                 120                 125             
Leu Thr Val Asn Pro Tyr 
    130                 

<210> 23
<211> 134
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3598_2 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 23
Met Asn Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      
Arg Thr Arg Gly Asp Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          
Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              
Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  
Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  
Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      
Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Arg 
            100                 105                 110         
Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr His 
        115                 120                 125             
Leu Ile Ile Gln Pro Tyr 
    130                 

<210> 24
<211> 133
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 24
Met Leu Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      
Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          
Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              
Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  
Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  
Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      
Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         
Thr Leu Asn Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg Leu 
        115                 120                 125             
His Ile Leu Pro Asn 
    130             

<210> 25
<211> 134
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412_2 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 25
Met Leu Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      
Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          
Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              
Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  
Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  
Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      
Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         
Thr Arg Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg 
        115                 120                 125             
Leu Ser Val Ile Ala Asn 
    130                 

<210> 26
<211> 133
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412_3 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 26
Met Leu Leu Glu His Leu Leu Ile Ile Leu Trp Met Gln Leu Thr Trp 
1               5                   10                  15      
Val Ser Gly Gln Gln Leu Asn Gln Ser Pro Gln Ser Met Phe Ile Gln 
            20                  25                  30          
Glu Gly Glu Asp Val Ser Met Asn Cys Thr Ser Ser Ser Ile Phe Asn 
        35                  40                  45              
Thr Trp Leu Trp Tyr Lys Gln Asp Pro Gly Glu Gly Pro Val Leu Leu 
    50                  55                  60                  
Ile Ala Leu Tyr Lys Ala Gly Glu Leu Thr Ser Asn Gly Arg Leu Thr 
65                  70                  75                  80  
Ala Gln Phe Gly Ile Thr Arg Lys Asp Ser Phe Leu Asn Ile Ser Ala 
                85                  90                  95      
Ser Ile Pro Ser Asp Val Gly Ile Tyr Phe Cys Ala Gly Gln Gln Asn 
            100                 105                 110         
Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu Leu 
        115                 120                 125             
Thr Val Asn Pro Asn 
    130             

<210> 27
<211> 132
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3600 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 27
Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      
Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          
Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              
Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  
Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  
Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      
Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Pro 
            100                 105                 110         
Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser 
        115                 120                 125             
Val Ile Ala Asn 
    130         

<210> 28
<211> 132
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5712 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 28
Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      
Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          
Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              
Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  
Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  
Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      
Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Pro 
            100                 105                 110         
Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser 
        115                 120                 125             
Val Ile Ala Asn 
    130         

<210> 29
<211> 132
<212> PRT
<213> Homo sapiens

<400> 29
Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      
Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          
Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              
Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  
Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  
Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      
Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Pro 
            100                 105                 110         
Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser 
        115                 120                 125             
Val Ile Ala Asn 
    130         

<210> 30
<211> 133
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5713 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 30
Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      
Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          
Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              
Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  
Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  
Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      
Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         
Ala Asn Gln Ala Gly Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu 
        115                 120                 125             
Ser Val Ser Ser Asn 
    130             

<210> 31
<211> 400
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3598 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 31
atgatgaaat ccttgagagt tttactggtg atcctgtggc ttcagttaag ctgggtttgg      60

agccaacaga aggaggtgga gcaggatcct ggaccactca gtgttccaga gggagccatt     120

gtttctctca actgcactta cagcaacagt gcttttcaat acttcatgtg gtacagacag     180

tattccagaa aaggccctga gttgctgatg tacacatact ccagtggtaa caaagaagat     240

ggaaggttta cagcacaggt cgataaatcc agcaagtata tctccttgtt catcagagac     300

tcacagccca gtgattcagc cacctacctc tgtgcaatga ggcagggcgg atctgaaaag     360

ctggtctttg gaaagggaac gaaactgaca gtaaacccat                           400


<210> 32
<211> 400
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3598_2 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 32
atgaactact ctcccggcct ggtgtctctg attctgctgc tgctgggccg gaccagaggc      60

gattctgtga cccagatgga aggccccgtg accctgagcg aggaagcctt cctgaccatc     120

aattgcacct acaccgccac cggctacccc agcctgtttt ggtacgtgca gtaccccggc     180

gagggcctgc agctgctgct gaaagccacc aaggccgacg acaagggcag caacaagggc     240

ttcgaggcca cctaccggaa agagacaacc agcttccacc tggaaaaggg cagcgtgcag     300

gtgtccgact ccgccgtgta tttctgcgcc ctgagagatt ctggcggcgg agccgatggc     360

ctgacctttg gcaagggcac acacctgatc atccagccct                           400


<210> 33
<211> 397
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 33
atgctcctgc tgctggtgcc tgccttccaa gtgatcttca ccctgggcgg caccagagcc      60

cagagcgtga cacagctgga tagccaggtg cccgtgttcg aagaggcccc tgtggaactg     120

cggtgcaact actccagcag cgtgtccgtg tacctgtttt ggtacgtgca gtaccccaac     180

cagggcctgc agctgctgct gaagtacctg agcggctcca ccctggtgga atccatcaac     240

ggcttcgagg ccgagttcaa caagagccag accagcttcc acctgagaaa gcccagcgtg     300

cacatcagcg ataccgccga gtacttctgc gccgtgaccc tgaaccggga cgacaagatc     360

atcttcggca agggcaccag actgcacatc ctgccca                              397


<210> 34
<211> 400
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412_2 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 34
atgctcctgc tgctggtgcc tgccttccaa gtgatcttca ccctgggcgg caccagggcc      60

cagtctgtga cacagctgga tagccaggtg cccgtgttcg aagaggcccc tgtggaactg     120

cggtgcaact actccagcag cgtgtccgtg tacctgtttt ggtacgtgca gtaccccaac     180

cagggcctgc agctgctgct gaagtacctg agcggctcca ccctggtgga atccatcaac     240

ggcttcgagg ccgagttcaa caagagccag accagcttcc atctgcggaa gcccagcgtg     300

cacatcagcg ataccgccga gtacttctgt gccgtgaccc ggaactccgg caacacccct     360

ctggtgtttg gcaagggcac acggctgagc gtgatcgcca                           400


<210> 35
<211> 397
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412_3 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 35
atgctgctgg aacatctgct gatcatcctg tggatgcagc tgacctgggt gtccggccag      60

cagctgaatc agagccccca gagcatgttc atccaggaag gcgaggacgt gtccatgaac     120

tgcaccagca gcagcatctt caatacctgg ctgtggtaca agcaggaccc cggcgaagga     180

cccgtgctgc tgatcgccct gtacaaagcc ggcgagctga ccagcaatgg caggctgaca     240

gcccagttcg gcattacccg gaaggacagc ttcctgaaca tcagcgcctc catccccagc     300

gacgtgggca tctatttctg cgccggacag cagaactccg gcggctccaa ctacaagctg     360

accttcggca agggcacact gctgacagtg aacccca                              397


<210> 36
<211> 394
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3600 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 36
atggtcaaaa tccggcagtt cctgctggcc atcctgtggc tgcagctgag ctgtgtgtcc      60

gccgccaaga acgaggtgga acagagcccc cagaacctga ccgctcagga aggcgagttc     120

atcaccatca actgcagcta cagcgtgggc atcagcgccc tgcattggct gcagcagcat     180

cctggcggag gcatcgtgtc tctgttcatg ctgagcagcg gaaagaagaa gcacggccgg     240

ctgatcgcca caatcaacat ccaggaaaag cacagcagcc tgcacatcac cgccagccac     300

cctagagaca gcgccgtgta catctgcgcc gtgcccaata gcggcaacac ccctctggtg     360

ttcggcaagg gcaccagact gagcgtgatc gcca                                 394


<210> 37
<211> 394
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5712 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 37
atggtcaaaa tccggcagtt cctgctggcc atcctgtggc tgcagctgag ctgtgtgtcc      60

gccgccaaga acgaggtgga acagagcccc cagaacctga ccgctcagga aggcgagttc     120

atcaccatca actgcagcta cagcgtgggc atcagcgccc tgcattggct gcagcagcat     180

cctggcggag gcatcgtgtc tctgttcatg ctgagcagcg gaaagaagaa gcacggccgg     240

ctgatcgcca caatcaacat ccaggaaaag cacagcagcc tgcacatcac cgccagccac     300

cctagagaca gcgccgtgta catctgcgcc gtgcccaata gcggcaacac ccctctggtg     360

ttcggcaagg gcaccagact gagcgtgatc gcca                                 394


<210> 38
<211> 394
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5415 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 38
atggtcaaaa tccggcagtt cctgctggcc atcctgtggc tgcagctgag ctgtgtgtcc      60

gccgccaaga acgaggtgga acagagcccc cagaacctga ccgctcagga aggcgagttc     120

atcaccatca actgcagcta cagcgtgggc atcagcgccc tgcattggct gcagcagcat     180

cctggcggag gcatcgtgtc tctgttcatg ctgagcagcg gaaagaagaa gcacggccgg     240

ctgatcgcca caatcaacat ccaggaaaag cacagcagcc tgcacatcac cgccagccac     300

cctagagaca gcgccgtgta catctgcgcc gtgcccaata gcggcaacac ccctctggtg     360

ttcggcaagg gcaccagact gagcgtgatc gcca                                 394


<210> 39
<211> 397
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5713 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 39
atgaagacct tcgccggctt cagcttcctg ttcctgtggc tgcagctgga ctgcatgagc      60

agaggcgagg acgtggaaca gagcctgttt ctgagcgtgc gcgagggcga cagcagcgtg     120

atcaattgca cctacaccga cagctccagc acatacctgt actggtataa gcaggaaccc     180

ggcgctggcc tgcagctgct gacctacatc ttctccaaca tggacatgaa gcaggaccag     240

cggctgacag tgctgctgaa caagaaggac aagcacctga gcctgcggat cgccgatacc     300

cagacaggcg actccgccat ctatttctgc gccgaggcca atcaggccgg caccgccctg     360

atctttggca agggcacaac actgagcgtg tccagca                              397


<210> 40
<211> 270
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR3598 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 40
Met Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      
Ser Trp Val Trp Ser Gln Gln Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          
Leu Ser Val Pro Glu Gly Ala Ile Val Ser Leu Asn Cys Thr Tyr Ser 
        35                  40                  45              
Asn Ser Ala Phe Gln Tyr Phe Met Trp Tyr Arg Gln Tyr Ser Arg Lys 
    50                  55                  60                  
Gly Pro Glu Leu Leu Met Tyr Thr Tyr Ser Ser Gly Asn Lys Glu Asp 
65                  70                  75                  80  
Gly Arg Phe Thr Ala Gln Val Asp Lys Ser Ser Lys Tyr Ile Ser Leu 
                85                  90                  95      
Phe Ile Arg Asp Ser Gln Pro Ser Asp Ser Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         
Met Arg Gln Gly Gly Ser Glu Lys Leu Val Phe Gly Lys Gly Thr Lys 
        115                 120                 125             
Leu Thr Val Asn Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 
Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 
Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     
Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         
Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             
Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 
Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 
Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 

<210> 41
<211> 270
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR3598_2 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 41
Met Asn Tyr Ser Pro Gly Leu Val Ser Leu Ile Leu Leu Leu Leu Gly 
1               5                   10                  15      
Arg Thr Arg Gly Asp Ser Val Thr Gln Met Glu Gly Pro Val Thr Leu 
            20                  25                  30          
Ser Glu Glu Ala Phe Leu Thr Ile Asn Cys Thr Tyr Thr Ala Thr Gly 
        35                  40                  45              
Tyr Pro Ser Leu Phe Trp Tyr Val Gln Tyr Pro Gly Glu Gly Leu Gln 
    50                  55                  60                  
Leu Leu Leu Lys Ala Thr Lys Ala Asp Asp Lys Gly Ser Asn Lys Gly 
65                  70                  75                  80  
Phe Glu Ala Thr Tyr Arg Lys Glu Thr Thr Ser Phe His Leu Glu Lys 
                85                  90                  95      
Gly Ser Val Gln Val Ser Asp Ser Ala Val Tyr Phe Cys Ala Leu Arg 
            100                 105                 110         
Asp Ser Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr His 
        115                 120                 125             
Leu Ile Ile Gln Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 
Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 
Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     
Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         
Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             
Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 
Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 
Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 

<210> 42
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5412 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 42
Met Leu Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      
Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          
Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              
Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  
Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  
Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      
Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         
Thr Leu Asn Arg Asp Asp Lys Ile Ile Phe Gly Lys Gly Thr Arg Leu 
        115                 120                 125             
His Ile Leu Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 
Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 
Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     
Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         
Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             
Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 
Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 
Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 

<210> 43
<211> 270
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5412_2 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 43
Met Leu Leu Leu Leu Val Pro Ala Phe Gln Val Ile Phe Thr Leu Gly 
1               5                   10                  15      
Gly Thr Arg Ala Gln Ser Val Thr Gln Leu Asp Ser Gln Val Pro Val 
            20                  25                  30          
Phe Glu Glu Ala Pro Val Glu Leu Arg Cys Asn Tyr Ser Ser Ser Val 
        35                  40                  45              
Ser Val Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Asn Gln Gly Leu Gln 
    50                  55                  60                  
Leu Leu Leu Lys Tyr Leu Ser Gly Ser Thr Leu Val Glu Ser Ile Asn 
65                  70                  75                  80  
Gly Phe Glu Ala Glu Phe Asn Lys Ser Gln Thr Ser Phe His Leu Arg 
                85                  90                  95      
Lys Pro Ser Val His Ile Ser Asp Thr Ala Glu Tyr Phe Cys Ala Val 
            100                 105                 110         
Thr Arg Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg 
        115                 120                 125             
Leu Ser Val Ile Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln 
    130                 135                 140                 
Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp 
145                 150                 155                 160 
Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe 
                165                 170                 175     
Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser 
            180                 185                 190         
Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp 
        195                 200                 205             
Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys 
    210                 215                 220                 
Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn 
225                 230                 235                 240 
Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val 
                245                 250                 255     
Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 270 

<210> 44
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5412_3 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 44
Met Leu Leu Glu His Leu Leu Ile Ile Leu Trp Met Gln Leu Thr Trp 
1               5                   10                  15      
Val Ser Gly Gln Gln Leu Asn Gln Ser Pro Gln Ser Met Phe Ile Gln 
            20                  25                  30          
Glu Gly Glu Asp Val Ser Met Asn Cys Thr Ser Ser Ser Ile Phe Asn 
        35                  40                  45              
Thr Trp Leu Trp Tyr Lys Gln Asp Pro Gly Glu Gly Pro Val Leu Leu 
    50                  55                  60                  
Ile Ala Leu Tyr Lys Ala Gly Glu Leu Thr Ser Asn Gly Arg Leu Thr 
65                  70                  75                  80  
Ala Gln Phe Gly Ile Thr Arg Lys Asp Ser Phe Leu Asn Ile Ser Ala 
                85                  90                  95      
Ser Ile Pro Ser Asp Val Gly Ile Tyr Phe Cys Ala Gly Gln Gln Asn 
            100                 105                 110         
Ser Gly Gly Ser Asn Tyr Lys Leu Thr Phe Gly Lys Gly Thr Leu Leu 
        115                 120                 125             
Thr Val Asn Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 
Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 
Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     
Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         
Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             
Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 
Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 
Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 

<210> 45
<211> 268
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR3600 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 45
Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      
Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          
Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              
Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  
Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  
Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      
Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Pro 
            100                 105                 110         
Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser 
        115                 120                 125             
Val Ile Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 
Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 
Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     
Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         
Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             
Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 
Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 
Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             

<210> 46
<211> 268
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5712 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 46
Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      
Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          
Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              
Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  
Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  
Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      
Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Pro 
            100                 105                 110         
Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser 
        115                 120                 125             
Val Ile Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 
Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 
Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     
Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         
Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             
Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 
Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 
Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             

<210> 47
<211> 268
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5415 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 47
Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      
Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          
Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              
Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  
Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  
Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      
Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Pro 
            100                 105                 110         
Asn Ser Gly Asn Thr Pro Leu Val Phe Gly Lys Gly Thr Arg Leu Ser 
        115                 120                 125             
Val Ile Ala Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 
Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 
Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     
Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         
Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             
Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 
Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 
Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             

<210> 48
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5713 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 48
Met Lys Thr Phe Ala Gly Phe Ser Phe Leu Phe Leu Trp Leu Gln Leu 
1               5                   10                  15      
Asp Cys Met Ser Arg Gly Glu Asp Val Glu Gln Ser Leu Phe Leu Ser 
            20                  25                  30          
Val Arg Glu Gly Asp Ser Ser Val Ile Asn Cys Thr Tyr Thr Asp Ser 
        35                  40                  45              
Ser Ser Thr Tyr Leu Tyr Trp Tyr Lys Gln Glu Pro Gly Ala Gly Leu 
    50                  55                  60                  
Gln Leu Leu Thr Tyr Ile Phe Ser Asn Met Asp Met Lys Gln Asp Gln 
65                  70                  75                  80  
Arg Leu Thr Val Leu Leu Asn Lys Lys Asp Lys His Leu Ser Leu Arg 
                85                  90                  95      
Ile Ala Asp Thr Gln Thr Gly Asp Ser Ala Ile Tyr Phe Cys Ala Glu 
            100                 105                 110         
Ala Asn Gln Ala Gly Thr Ala Leu Ile Phe Gly Lys Gly Thr Thr Leu 
        115                 120                 125             
Ser Val Ser Ser Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 
Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 
Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     
Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         
Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             
Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 
Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 
Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 

<210> 49
<211> 813
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3598 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 49
atgatgaagt ccctgcgggt gctgctcgtg atcctgtggc tgcagctgag ctgggtgtgg      60

tcccagcaga aagaggtgga acaggaccca ggccctctga gcgtgccaga gggcgctatc     120

gtgtccctga attgcaccta cagcaacagc gccttccagt acttcatgtg gtatcggcag     180

tacagccgga agggccccga gctgctgatg tacacctact ccagcggcaa caaagaggac     240

ggccggttca cagcccaggt ggacaagagc agcaagtaca tctccctgtt catccgggac     300

agccagccca gcgacagcgc cacatatctg tgcgccatga gacagggcgg ctccgagaag     360

ctggtgttcg gcaagggcac aaagctgacc gtgaacccct acatccagaa ccccgagccc     420

gccgtgtacc agctgaagga ccctagaagc caggacagca ccctgtgcct gttcaccgac     480

ttcgacagcc agatcaacgt gcccaagacc atggaaagcg gcaccttcat caccgacaag     540

accgtgctgg acatgaaggc catggacagc aagagcaacg gcgccattgc ctggtccaac     600

cagaccagct tcacatgcca ggacatcttc aaagagacaa acgccaccta ccccagcagc     660

gacgtgccct gtgatgccac cctgaccgag aagtctttcg agacagacat gaacctgaac     720

ttccagaacc tgagcgtgat gggcctgaga atcctgctgc tgaaagtggc cggattcaac     780

ctgctgatga ccctgcggct gtggtccagc tga                                  813


<210> 50
<211> 813
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3598_2 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 50
atgaactact ctcccggcct ggtgtctctg attctgctgc tgctgggccg gaccagaggc      60

gattctgtga cccagatgga aggccccgtg accctgagcg aggaagcctt cctgaccatc     120

aattgcacct acaccgccac cggctacccc agcctgtttt ggtacgtgca gtaccccggc     180

gagggcctgc agctgctgct gaaagccacc aaggccgacg acaagggcag caacaagggc     240

ttcgaggcca cctaccggaa agagacaacc agcttccacc tggaaaaggg cagcgtgcag     300

gtgtccgact ccgccgtgta tttctgcgcc ctgagagatt ctggcggcgg agccgatggc     360

ctgacctttg gcaagggcac acacctgatc atccagccct acatccagaa ccccgagcct     420

gccgtgtacc agctgaagga ccctagaagc caggacagca ccctgtgcct gttcaccgac     480

ttcgacagcc agatcaacgt gcccaagacc atggaaagcg gcaccttcat caccgacaag     540

accgtgctgg acatgaaggc catggacagc aagagcaacg gcgccattgc ctggtccaac     600

cagaccagct tcacatgcca ggacatcttc aaagagacta acgccacata ccccagcagc     660

gacgtgccct gtgatgccac cctgaccgag aagtctttcg agacagacat gaacctgaac     720

ttccagaacc tgagcgtgat gggcctgaga atcctgctgc tgaaggtggc cggcttcaac     780

ctgctgatga ccctgagact gtggtccagc tga                                  813


<210> 51
<211> 810
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 51
atgctcctgc tgctggtgcc tgccttccaa gtgatcttca ccctgggcgg caccagagcc      60

cagagcgtga cacagctgga tagccaggtg cccgtgttcg aagaggcccc tgtggaactg     120

cggtgcaact actccagcag cgtgtccgtg tacctgtttt ggtacgtgca gtaccccaac     180

cagggcctgc agctgctgct gaagtacctg agcggctcca ccctggtgga atccatcaac     240

ggcttcgagg ccgagttcaa caagagccag accagcttcc acctgagaaa gcccagcgtg     300

cacatcagcg ataccgccga gtacttctgc gccgtgaccc tgaaccggga cgacaagatc     360

atcttcggca agggcaccag actgcacatc ctgcccaaca tccagaaccc cgagcccgcc     420

gtgtaccagc tgaaggaccc tagaagccag gatagcaccc tgtgtctgtt caccgacttc     480

gacagccaga tcaacgtgcc caagaccatg gaaagcggca ccttcatcac cgacaagaca     540

gtgctggaca tgaaggccat ggacagcaag agcaacggcg ccattgcctg gtccaaccag     600

acaagcttca catgccagga catcttcaaa gagacaaacg ccacctaccc cagctccgac     660

gtgccctgtg atgccaccct gaccgagaag tccttcgaga cagacatgaa cctgaatttc     720

cagaacctga gcgtgatggg cctgcggatc ctgctgctga aagtggccgg cttcaacctg     780

ctgatgaccc tgagactgtg gtccagctga                                      810


<210> 52
<211> 813
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412_2 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 52
atgctcctgc tgctggtgcc tgccttccaa gtgatcttca ccctgggcgg caccagggcc      60

cagtctgtga cacagctgga tagccaggtg cccgtgttcg aagaggcccc tgtggaactg     120

cggtgcaact actccagcag cgtgtccgtg tacctgtttt ggtacgtgca gtaccccaac     180

cagggcctgc agctgctgct gaagtacctg agcggctcca ccctggtgga atccatcaac     240

ggcttcgagg ccgagttcaa caagagccag accagcttcc atctgcggaa gcccagcgtg     300

cacatcagcg ataccgccga gtacttctgt gccgtgaccc ggaactccgg caacacccct     360

ctggtgtttg gcaagggcac acggctgagc gtgatcgcca atatccagaa ccccgagcct     420

gccgtgtacc agctgaagga ccccagaagc caggatagca ccctgtgcct gttcaccgac     480

ttcgacagcc agatcaatgt gcccaagacc atggaaagcg gcaccttcat caccgacaag     540

accgtgctgg acatgaaggc catggacagc aagagcaacg gcgccattgc ctggtccaac     600

cagacaagct tcacatgcca ggacatcttc aaagagacaa acgccaccta ccccagctcc     660

gacgtgccct gtgatgccac cctgaccgag aagtccttcg agacagacat gaacctgaac     720

ttccagaacc tgtccgtgat gggcctgcgg atcctgctgc tgaaagtggc cggcttcaac     780

ctgctgatga ccctgagact gtggtccagc tga                                  813


<210> 53
<211> 810
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412_3 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 53
atgctgctgg aacatctgct gatcatcctg tggatgcagc tgacctgggt gtccggccag      60

cagctgaatc agagccccca gagcatgttc atccaggaag gcgaggacgt gtccatgaac     120

tgcaccagca gcagcatctt caatacctgg ctgtggtaca agcaggaccc cggcgaagga     180

cccgtgctgc tgatcgccct gtacaaagcc ggcgagctga ccagcaatgg caggctgaca     240

gcccagttcg gcattacccg gaaggacagc ttcctgaaca tcagcgcctc catccccagc     300

gacgtgggca tctatttctg cgccggacag cagaactccg gcggctccaa ctacaagctg     360

accttcggca agggcacact gctgacagtg aaccccaaca tccagaaccc cgagcccgcc     420

gtgtaccagc tgaaggaccc tagaagccag gacagcaccc tgtgcctgtt caccgacttc     480

gacagccaga tcaacgtgcc caagaccatg gaaagcggca ccttcatcac cgacaagacc     540

gtgctggaca tgaaggccat ggacagcaag agcaacggcg caatcgcctg gtccaaccag     600

accagcttca catgccagga catcttcaaa gagacaaacg ccacctaccc cagctccgac     660

gtgccctgtg atgccaccct gaccgagaag tccttcgaga cagacatgaa cctgaacttc     720

cagaatctga gcgtgatggg cctgcgcatc ctgctgctga aggtggccgg ctttaacctg     780

ctgatgaccc tgcggctgtg gtccagctga                                      810


<210> 54
<211> 807
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3600 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 54
atggtcaaaa tccggcagtt cctgctggcc atcctgtggc tgcagctgag ctgtgtgtcc      60

gccgccaaga acgaggtgga acagagcccc cagaacctga ccgctcagga aggcgagttc     120

atcaccatca actgcagcta cagcgtgggc atcagcgccc tgcattggct gcagcagcat     180

cctggcggag gcatcgtgtc tctgttcatg ctgagcagcg gaaagaagaa gcacggccgg     240

ctgatcgcca caatcaacat ccaggaaaag cacagcagcc tgcacatcac cgccagccac     300

cctagagaca gcgccgtgta catctgcgcc gtgcccaata gcggcaacac ccctctggtg     360

ttcggcaagg gcaccagact gagcgtgatc gccaatatcc agaaccccga gcctgccgtg     420

taccagctga aggaccctag aagccaggac agcaccctgt gcctgttcac cgacttcgac     480

agccagatca acgtgcccaa gaccatggaa agcggcacct tcatcaccga caagaccgtg     540

ctggacatga aggccatgga cagcaagagc aacggcgcca ttgcctggtc caaccagacc     600

agcttcacat gccaggacat cttcaaagag acaaacgcca cctaccccag cagcgacgtg     660

ccctgtgatg ccaccctgac cgagaagtct ttcgagacag acatgaacct gaacttccag     720

aatctgtccg tgatgggcct gagaatcctg ctgctgaaag tggccggatt caacctgctg     780

atgaccctgc ggctgtggtc cagctga                                         807


<210> 55
<211> 807
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5712 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 55
atggtcaaaa tccggcagtt cctgctggcc atcctgtggc tgcagctgag ctgtgtgtcc      60

gccgccaaga acgaggtgga acagagcccc cagaacctga ccgctcagga aggcgagttc     120

atcaccatca actgcagcta cagcgtgggc atcagcgccc tgcattggct gcagcagcat     180

cctggcggag gcatcgtgtc tctgttcatg ctgagcagcg gaaagaagaa gcacggccgg     240

ctgatcgcca caatcaacat ccaggaaaag cacagcagcc tgcacatcac cgccagccac     300

cctagagaca gcgccgtgta catctgcgcc gtgcccaata gcggcaacac ccctctggtg     360

ttcggcaagg gcaccagact gagcgtgatc gccaatatcc agaaccccga gcctgccgtg     420

taccagctga aggaccctag aagccaggac agcaccctgt gcctgttcac cgacttcgac     480

agccagatca acgtgcccaa gaccatggaa agcggcacct tcatcaccga caagaccgtg     540

ctggacatga aggccatgga cagcaagagc aacggcgcca ttgcctggtc caaccagacc     600

agcttcacat gccaggacat cttcaaagag acaaacgcca cctaccccag cagcgacgtg     660

ccctgtgatg ccaccctgac cgagaagtct ttcgagacag acatgaacct gaacttccag     720

aatctgtccg tgatgggcct gagaatcctg ctgctgaaag tggccggatt caacctgctg     780

atgaccctgc ggctgtggtc cagctga                                         807


<210> 56
<211> 807
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5415 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 56
atggtcaaaa tccggcagtt cctgctggcc atcctgtggc tgcagctgag ctgtgtgtcc      60

gccgccaaga acgaggtgga acagagcccc cagaacctga ccgctcagga aggcgagttc     120

atcaccatca actgcagcta cagcgtgggc atcagcgccc tgcattggct gcagcagcat     180

cctggcggag gcatcgtgtc tctgttcatg ctgagcagcg gaaagaagaa gcacggccgg     240

ctgatcgcca caatcaacat ccaggaaaag cacagcagcc tgcacatcac cgccagccac     300

cctagagaca gcgccgtgta catctgcgcc gtgcccaata gcggcaacac ccctctggtg     360

ttcggcaagg gcaccagact gagcgtgatc gccaatatcc agaaccccga gcctgccgtg     420

taccagctga aggaccctag aagccaggac agcaccctgt gcctgttcac cgacttcgac     480

agccagatca acgtgcccaa gaccatggaa agcggcacct tcatcaccga caagaccgtg     540

ctggacatga aggccatgga cagcaagagc aacggcgcca ttgcctggtc caaccagacc     600

agcttcacat gccaggacat cttcaaagag acaaacgcca cctaccccag cagcgacgtg     660

ccctgtgatg ccaccctgac cgagaagtct ttcgagacag acatgaacct gaacttccag     720

aatctgtccg tgatgggcct gagaatcctg ctgctgaaag tggccggatt caacctgctg     780

atgaccctgc ggctgtggtc cagctga                                         807


<210> 57
<211> 810
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5713 TCR alpha chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 57
atgaagacct tcgccggctt cagcttcctg ttcctgtggc tgcagctgga ctgcatgagc      60

agaggcgagg acgtggaaca gagcctgttt ctgagcgtgc gcgagggcga cagcagcgtg     120

atcaattgca cctacaccga cagctccagc acatacctgt actggtataa gcaggaaccc     180

ggcgctggcc tgcagctgct gacctacatc ttctccaaca tggacatgaa gcaggaccag     240

cggctgacag tgctgctgaa caagaaggac aagcacctga gcctgcggat cgccgatacc     300

cagacaggcg actccgccat ctatttctgc gccgaggcca atcaggccgg caccgccctg     360

atctttggca agggcacaac actgagcgtg tccagcaaca tccagaaccc cgagcccgcc     420

gtgtaccagc tgaaggaccc tagaagccag gacagcaccc tgtgcctgtt caccgacttc     480

gacagccaga tcaacgtgcc caagaccatg gaaagcggca ccttcatcac cgacaagact     540

gtgctggata tgaaggccat ggacagcaag agcaacggcg ccattgcctg gtccaaccag     600

accagcttca catgccagga catcttcaaa gagacaaacg ccacctaccc cagcagcgac     660

gtgccctgtg atgccaccct gaccgagaag tctttcgaga cagacatgaa cctgaacttc     720

cagaacctga gcgtgatggg cctgagaatc ctgctgctga aggtggccgg cttcaacctg     780

ctgatgaccc tgagactgtg gtccagctga                                      810


<210> 58
<211> 133
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3598 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 58
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Gly Gln Gly Ala Gly Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             
Leu Leu Val Leu Glu 
    130             

<210> 59
<211> 135
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3598_2 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 59
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Val Met Thr Gly Leu Asn Thr Glu Ala Phe Phe Gly Gln Gly 
        115                 120                 125             
Thr Arg Leu Thr Val Val Glu 
    130                 135 

<210> 60
<211> 134
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 60
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      
Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr 
            20                  25                  30          
Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              
Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  
Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  
Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      
Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         
Ser Ser Leu Asp Arg Pro Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             
Arg Leu Thr Val Leu Glu 
    130                 

<210> 61
<211> 135
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412_2 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 61
Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      
Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          
Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              
Asn Ser Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  
Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  
Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      
Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Phe Leu Ala Ser Val Gly Tyr Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             
Thr Arg Leu Thr Val Thr Glu 
    130                 135 

<210> 62
<211> 132
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5412_3 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 62
Met Asp Thr Arg Val Leu Cys Cys Ala Val Ile Cys Leu Leu Gly Ala 
1               5                   10                  15      
Gly Leu Ser Asn Ala Gly Val Met Gln Asn Pro Arg His Leu Val Arg 
            20                  25                  30          
Arg Arg Gly Gln Glu Ala Arg Leu Arg Cys Ser Pro Met Lys Gly His 
        35                  40                  45              
Ser His Val Tyr Trp Tyr Arg Gln Leu Pro Glu Glu Gly Leu Lys Phe 
    50                  55                  60                  
Met Val Tyr Leu Gln Lys Glu Asn Ile Ile Asp Glu Ser Gly Met Pro 
65                  70                  75                  80  
Lys Glu Arg Phe Ser Ala Glu Phe Pro Lys Glu Gly Pro Ser Ile Leu 
                85                  90                  95      
Arg Ile Gln Gln Val Val Arg Gly Asp Ser Ala Ala Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Pro Pro Leu Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             
Thr Val Thr Glu 
    130         

<210> 63
<211> 131
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR3600 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 63
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Val Ile Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             
Val Thr Glu 
    130     

<210> 64
<211> 131
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5712 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 64
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Ile Ile Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             
Val Thr Glu 
    130     

<210> 65
<211> 131
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5415 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 65
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Val Tyr Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             
Val Thr Glu 
    130     

<210> 66
<211> 136
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR5713 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 66
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Ser Gly Leu Ala Gly Val Thr Gly Glu Leu Phe Phe Gly Glu 
        115                 120                 125             
Gly Ser Arg Leu Thr Val Leu Glu 
    130                 135     

<210> 67
<211> 397
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3598 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 67
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcggccaggg cgctggcacc     360

cagtattttg gccctggcac cagactgctg gtgctgg                              397


<210> 68
<211> 403
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3598_2 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 68
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcgtgatgac cggcctgaac     360

accgaggcat tctttgggca gggcacccgg ctgaccgtgg tgg                       403


<210> 69
<211> 400
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 69
atgggaacat ctctgctgtg ttggatggcc ctgtgcctgc tgggagccga tcatgccgat      60

acaggcgtgt cccaggaccc ccggcacaag attaccaagc ggggccagaa cgtgaccttc     120

agatgcgacc ccatcagcga gcacaaccgg ctgtactggt acagacagac cctgggccag     180

ggccccgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag ccggctgctg     240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagcgg     300

accgagcagg gcgacagcgc catgtatctg tgtgccagca gcctggaccg gccctacaac     360

gagcagttct ttggcccagg cacccggctg accgtgctgg                           400


<210> 70
<211> 403
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412_2 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 70
atggatagct ggaccttttg ctgcgtgtcc ctgtgcatcc tggtggccaa gcacacagat      60

gccggcgtga tccagagccc cagacacgaa gtgaccgaga tgggccagga agtgaccctg     120

cgctgcaagc ctatcagcgg ccacaacagc ctgttctggt acagacagac catgatgcgg     180

ggcctggaac tgctgatcta cttcaacaac aacgtgccca tcgacgacag cggcatgccc     240

gaggatagat tcagcgccaa gatgcccaac gccagcttca gcaccctgaa gatccagccc     300

agcgagccca gagacagcgc cgtgtacttt tgcgccagca gctttctggc cagcgtgggc     360

tacgagcagt acttcggccc tggcaccaga ctgaccgtga ccg                       403


<210> 71
<211> 397
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412_3 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 71
atggatacca gagtgctgtg ctgcgccgtg atctgcctgc tgggagccgg actgtctaat      60

gccggcgtga tgcagaaccc cagacacctc gtgcggcgga gaggacagga agccagactg     120

cgctgcagcc ccatgaaggg ccacagccac gtgtactggt acagacagct gcccgaagag     180

ggcctgaagt tcatggtgta cctgcagaaa gagaacatca tcgacgagag cggcatgccc     240

aaagagcggt tcagcgccga gttccccaaa gagggcccca gcatcctgag aatccagcag     300

gtcgtgcggg gcgatagcgc cgcctacttt tgtgccagct ctccacctct gggcgagcag     360

tactttggcc ctggcaccag actgaccgtg accgagg                              397


<210> 72
<211> 391
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3600 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 72
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcgtgatcta cgagcagtac     360

ttcggccctg gcacccggct gaccgtgacc g                                    391


<210> 73
<211> 391
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5712 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 73
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcatcatcta cgagcagtac     360

ttcggccctg gcacccggct gaccgtgacc g                                    391


<210> 74
<211> 391
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5415 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 74
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcgtgtacta cgagcagtac     360

ttcggccctg gcacccggct gaccgtgacc g                                    391


<210> 75
<211> 406
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5713 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135 , variable region

<400> 75
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gctctggact ggccggcgtg     360

acaggcgagc tgttttttgg cgagggcagc agactgaccg tgctgg                    406


<210> 76
<211> 305
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR3598 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 76
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Gly Gln Gly Ala Gly Thr Gln Tyr Phe Gly Pro Gly Thr Arg 
        115                 120                 125             
Leu Leu Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 
Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 
Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     
Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         
Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             
Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 
Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 
Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     
Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser 
            260                 265                 270         
Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             
Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn 
    290                 295                 300                 
Ser 
305 

<210> 77
<211> 307
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR3598_2 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 77
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Val Met Thr Gly Leu Asn Thr Glu Ala Phe Phe Gly Gln Gly 
        115                 120                 125             
Thr Arg Leu Thr Val Val Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 
Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 
Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         
Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             
Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 
Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 
Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     
Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val 
            260                 265                 270         
Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             
Tyr Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys 
    290                 295                 300                 
Lys Asn Ser 
305         

<210> 78
<211> 306
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5412 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 78
Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      
Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr 
            20                  25                  30          
Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              
Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  
Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  
Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      
Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         
Ser Ser Leu Asp Arg Pro Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             
Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 
Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 
Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         
Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             
Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 
Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 
Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     
Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         
Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             
Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 
Asn Ser 
305     

<210> 79
<211> 307
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5412_2 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 79
Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      
Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          
Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              
Asn Ser Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  
Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  
Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      
Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Phe Leu Ala Ser Val Gly Tyr Glu Gln Tyr Phe Gly Pro Gly 
        115                 120                 125             
Thr Arg Leu Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys 
    130                 135                 140                 
Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys 
145                 150                 155                 160 
Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu 
                165                 170                 175     
Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr 
            180                 185                 190         
Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser 
        195                 200                 205             
Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe 
    210                 215                 220                 
Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro 
225                 230                 235                 240 
Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp 
                245                 250                 255     
Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val 
            260                 265                 270         
Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
        275                 280                 285             
Tyr Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys 
    290                 295                 300                 
Lys Asn Ser 
305         

<210> 80
<211> 304
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5412_3 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 80
Met Asp Thr Arg Val Leu Cys Cys Ala Val Ile Cys Leu Leu Gly Ala 
1               5                   10                  15      
Gly Leu Ser Asn Ala Gly Val Met Gln Asn Pro Arg His Leu Val Arg 
            20                  25                  30          
Arg Arg Gly Gln Glu Ala Arg Leu Arg Cys Ser Pro Met Lys Gly His 
        35                  40                  45              
Ser His Val Tyr Trp Tyr Arg Gln Leu Pro Glu Glu Gly Leu Lys Phe 
    50                  55                  60                  
Met Val Tyr Leu Gln Lys Glu Asn Ile Ile Asp Glu Ser Gly Met Pro 
65                  70                  75                  80  
Lys Glu Arg Phe Ser Ala Glu Phe Pro Lys Glu Gly Pro Ser Ile Leu 
                85                  90                  95      
Arg Ile Gln Gln Val Val Arg Gly Asp Ser Ala Ala Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Pro Pro Leu Gly Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             
Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 
Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 
Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     
Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         
Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             
Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 
Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 
Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     
Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala 
            260                 265                 270         
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             
Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300                 



<210> 81
<211> 303
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR3600 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 81
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Val Ile Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             
Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 
Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 
Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     
Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala 
            180                 185                 190         
Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             
Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 
Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 
Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     
Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         
Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             
Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300             

<210> 82
<211> 303
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5712 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 82
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Ile Ile Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             
Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 
Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 
Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     
Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala 
            180                 185                 190         
Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             
Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 
Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 
Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     
Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         
Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             
Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300             

<210> 83
<211> 303
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5415 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 83
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Val Tyr Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
        115                 120                 125             
Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe 
    130                 135                 140                 
Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val 
145                 150                 155                 160 
Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
                165                 170                 175     
Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala 
            180                 185                 190         
Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val 
        195                 200                 205             
Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val 
    210                 215                 220                 
Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro 
225                 230                 235                 240 
Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp 
                245                 250                 255     
Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr 
            260                 265                 270         
Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
        275                 280                 285             
Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300             

<210> 84
<211> 308
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR5713 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 84
Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      
Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          
Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              
Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  
Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  
Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      
Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         
Ser Ser Ser Gly Leu Ala Gly Val Thr Gly Glu Leu Phe Phe Gly Glu 
        115                 120                 125             
Gly Ser Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro 
    130                 135                 140                 
Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln 
145                 150                 155                 160 
Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val 
                165                 170                 175     
Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser 
            180                 185                 190         
Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser 
        195                 200                 205             
Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His 
    210                 215                 220                 
Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp 
225                 230                 235                 240 
Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala 
                245                 250                 255     
Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly 
            260                 265                 270         
Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
        275                 280                 285             
Leu Tyr Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys 
    290                 295                 300                 
Lys Lys Asn Ser 
305             

<210> 85
<211> 918
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3598 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 85
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcggccaggg cgctggcacc     360

cagtattttg gccctggcac cagactgctg gtgctggaag atctgcggaa cgtgaccccc     420

cccaaggtgt ccctgttcga gcctagcaag gccgagatcg ccaacaagca gaaagccacc     480

ctcgtgtgcc tggccagagg cttcttcccc gaccacgtgg aactgtcttg gtgggtcaac     540

ggcaaagagg tgcacagcgg cgtgtccacc gatccccagg cctacaaaga gagcaactac     600

agctactgcc tgtccagcag actgcgggtg tccgccacct tctggcacaa cccccggaac     660

cacttcagat gccaggtgca gtttcacggc ctgagcgaag aggacaagtg gcctgagggc     720

agccccaagc ccgtgactca gaatatctct gccgaggcat ggggcagagc cgactgtggc     780

attaccagcg ccagctacca tcagggcgtg ctgagcgcca ccatcctgta cgagatcctg     840

ctgggcaagg ccaccctgta cgccgtgctg gtgtcaggcc tggtgctgat ggccatggtc     900

aagaagaaga acagctga                                                   918


<210> 86
<211> 924
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3598_2 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 86
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcgtgatgac cggcctgaac     360

accgaggcat tctttgggca gggcacccgg ctgaccgtgg tggaagatct gagaaacgtg     420

acccccccca aggtgtccct gttcgagcct agcaaggccg agatcgccaa caagcagaaa     480

gccaccctcg tgtgcctggc cagaggcttc ttccccgacc acgtggaact gtcttggtgg     540

gtcaacggca aagaggtgca cagcggcgtg tccaccgatc cccaggccta caaagagagc     600

aactacagct actgcctgtc cagcagactg cgggtgtccg ccaccttctg gcacaacccc     660

cggaaccact tcagatgcca ggtgcagttt cacggcctga gcgaagagga caagtggcct     720

gagggcagcc ccaagcccgt gactcagaat atctctgccg aggcatgggg cagagccgac     780

tgtggcatta ccagcgccag ctaccatcag ggcgtgctga gcgccaccat cctgtacgag     840

atcctgctgg gcaaggccac cctgtacgcc gtgctggtgt ctggcctggt gctgatggcc     900

atggtcaaga agaagaacag ctga                                            924


<210> 87
<211> 921
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 87
atgggaacat ctctgctgtg ttggatggcc ctgtgcctgc tgggagccga tcatgccgat      60

acaggcgtgt cccaggaccc ccggcacaag attaccaagc ggggccagaa cgtgaccttc     120

agatgcgacc ccatcagcga gcacaaccgg ctgtactggt acagacagac cctgggccag     180

ggccccgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag ccggctgctg     240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagcgg     300

accgagcagg gcgacagcgc catgtatctg tgtgccagca gcctggaccg gccctacaac     360

gagcagttct ttggcccagg cacccggctg accgtgctgg aagatctgag aaacgtgacc     420

ccccccaagg tgtccctgtt cgagcctagc aaggccgaga tcgccaacaa gcagaaagcc     480

accctcgtgt gcctggccag aggcttcttc cccgaccacg tggaactgtc ttggtgggtc     540

aacggcaaag aggtgcacag cggcgtgtcc accgatcccc aggcctacaa agagagcaac     600

tacagctact gcctgagcag cagactgcgg gtgtccgcca ccttctggca caacccccgg     660

aaccacttca ggtgccaggt gcagtttcac ggcctgagcg aagaggacaa gtggcccgag     720

ggcagcccta agcccgtgac ccagaatatc tctgccgaag cctggggcag agccgactgt     780

ggcattacca gcgccagcta ccatcagggc gtgctgagcg ccaccatcct gtacgagatc     840

ctgctgggca aggccaccct gtacgccgtg ctggtgtctg gcctggtgct gatggccatg     900

gtcaagaaga agaacagctg a                                               921


<210> 88
<211> 924
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412_2 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 88
atggatagct ggaccttttg ctgcgtgtcc ctgtgcatcc tggtggccaa gcacacagat      60

gccggcgtga tccagagccc cagacacgaa gtgaccgaga tgggccagga agtgaccctg     120

cgctgcaagc ctatcagcgg ccacaacagc ctgttctggt acagacagac catgatgcgg     180

ggcctggaac tgctgatcta cttcaacaac aacgtgccca tcgacgacag cggcatgccc     240

gaggatagat tcagcgccaa gatgcccaac gccagcttca gcaccctgaa gatccagccc     300

agcgagccca gagacagcgc cgtgtacttt tgcgccagca gctttctggc cagcgtgggc     360

tacgagcagt acttcggccc tggcaccaga ctgaccgtga ccgaggacct gagaaacgtg     420

acccccccca aagtgtctct gttcgagccc agcaaggccg agatcgccaa caagcagaaa     480

gccaccctcg tgtgcctggc cagaggcttc ttccccgacc acgtggaact gtcttggtgg     540

gtcaacggca aagaggtgca cagcggcgtg tccaccgatc cccaggccta caaagagagc     600

aactacagct actgcctgag cagcagactg cgggtgtccg ccaccttctg gcacaacccc     660

cggaaccact tcagatgcca ggtgcagttt cacggcctga gcgaagagga caagtggccc     720

gagggcagcc ctaagcccgt gacccagaat atctctgccg aagcctgggg cagagccgac     780

tgtggcatta ccagcgccag ctaccatcag ggcgtgctga gcgccaccat cctgtacgag     840

atcctgctgg gcaaggccac cctgtacgcc gtgctggtgt ctggcctggt gctgatggcc     900

atggtcaaga agaagaacag ctga                                            924


<210> 89
<211> 915
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412_3 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 89
atggatacca gagtgctgtg ctgcgccgtg atctgcctgc tgggagccgg actgtctaat      60

gccggcgtga tgcagaaccc cagacacctc gtgcggcgga gaggacagga agccagactg     120

cgctgcagcc ccatgaaggg ccacagccac gtgtactggt acagacagct gcccgaagag     180

ggcctgaagt tcatggtgta cctgcagaaa gagaacatca tcgacgagag cggcatgccc     240

aaagagcggt tcagcgccga gttccccaaa gagggcccca gcatcctgag aatccagcag     300

gtcgtgcggg gcgatagcgc cgcctacttt tgtgccagct ctccacctct gggcgagcag     360

tactttggcc ctggcaccag actgaccgtg accgaggacc tgagaaacgt gacccccccc     420

aaggtgtccc tgttcgagcc tagcaaggcc gagatcgcca acaagcagaa agccaccctc     480

gtgtgcctgg ccagaggctt cttccccgac cacgtggaac tgtcttggtg ggtcaacggc     540

aaagaggtgc acagcggcgt gtccaccgat ccccaggcct acaaagagag caactacagc     600

tactgcctga gcagcagact gcgggtgtcc gccaccttct ggcacaaccc ccggaaccac     660

ttcagatgcc aggtgcagtt tcacggcctg agcgaagagg acaagtggcc cgagggcagc     720

cctaagcccg tgacccagaa tatctctgcc gaagcctggg gcagagccga ctgtggcatt     780

accagcgcca gctaccatca gggcgtgctg agcgccacca tcctgtacga gatcctgctg     840

ggcaaggcca ccctgtacgc cgtgctggtg tctggcctgg tgctgatggc catggtcaag     900

aagaagaaca gctga                                                      915


<210> 90
<211> 912
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3600 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 90
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcgtgatcta cgagcagtac     360

ttcggccctg gcacccggct gaccgtgacc gaggatctga gaaacgtgac cccccccaag     420

gtgtccctgt tcgagcctag caaggccgag atcgccaaca agcagaaagc caccctcgtg     480

tgcctggcca gaggcttctt ccccgaccac gtggaactgt cttggtgggt caacggcaaa     540

gaggtgcaca gcggcgtgtc caccgatccc caggcctaca aagagagcaa ctacagctac     600

tgcctgtcca gcagactgcg ggtgtccgcc accttctggc acaacccccg gaaccacttc     660

agatgccagg tgcagtttca cggcctgagc gaagaggaca agtggcctga gggcagcccc     720

aagcccgtga ctcagaatat ctctgccgag gcatggggca gagccgactg tggcattacc     780

agcgccagct accatcaggg cgtgctgagc gccaccatcc tgtacgagat cctgctgggc     840

aaggccaccc tgtacgccgt gctggtgtct ggcctggtgc tgatggccat ggtcaagaag     900

aagaacagct ga                                                         912


<210> 91
<211> 912
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5712 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 91
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcatcatcta cgagcagtac     360

ttcggccctg gcacccggct gaccgtgacc gaggatctga gaaacgtgac cccccccaag     420

gtgtccctgt tcgagcctag caaggccgag atcgccaaca agcagaaagc caccctcgtg     480

tgcctggcca gaggcttctt ccccgaccac gtggaactgt cttggtgggt caacggcaaa     540

gaggtgcaca gcggcgtgtc caccgatccc caggcctaca aagagagcaa ctacagctac     600

tgcctgtcca gcagactgcg ggtgtccgcc accttctggc acaacccccg gaaccacttc     660

agatgccagg tgcagtttca cggcctgagc gaagaggaca agtggcctga gggcagcccc     720

aagcccgtga ctcagaatat ctctgccgag gcatggggca gagccgactg tggcattacc     780

agcgccagct accatcaggg cgtgctgagc gccaccatcc tgtacgagat cctgctgggc     840

aaggccaccc tgtacgccgt gctggtgtct ggcctggtgc tgatggccat ggtcaagaag     900

aagaacagct ga                                                         912


<210> 92
<211> 912
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5415 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 92
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcgtgtacta cgagcagtac     360

ttcggccctg gcacccggct gaccgtgacc gaggatctga gaaacgtgac cccccccaag     420

gtgtccctgt tcgagcctag caaggccgag atcgccaaca agcagaaagc caccctcgtg     480

tgcctggcca gaggcttctt ccccgaccac gtggaactgt cttggtgggt caacggcaaa     540

gaggtgcaca gcggcgtgtc caccgatccc caggcctaca aagagagcaa ctacagctac     600

tgcctgtcca gcagactgcg ggtgtccgcc accttctggc acaacccccg gaaccacttc     660

agatgccagg tgcagtttca cggcctgagc gaagaggaca agtggcctga gggcagcccc     720

aagcccgtga ctcagaatat ctctgccgag gcatggggca gagccgactg tggcattacc     780

agcgccagct accatcaggg cgtgctgagc gccaccatcc tgtacgagat cctgctgggc     840

aaggccaccc tgtacgccgt gctggtgtct ggcctggtgc tgatggccat ggtcaagaag     900

aagaacagct ga                                                         912


<210> 93
<211> 927
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5713 TCR beta chain specific for HLA-DR4 epitope NY-ESO-1
      116-135

<400> 93
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gctctggact ggccggcgtg     360

acaggcgagc tgttttttgg cgagggcagc agactgaccg tgctggaaga tctgcggaac     420

gtgacccccc ccaaggtgtc cctgttcgag cctagcaagg ccgagatcgc caacaagcag     480

aaagccaccc tcgtgtgcct ggccagaggc ttcttccccg accacgtgga actgtcttgg     540

tgggtcaacg gcaaagaggt gcacagcggc gtgtccaccg atccccaggc ctacaaagag     600

agcaactaca gctactgcct gtcctcccgg ctgagagtgt ccgccacctt ctggcacaac     660

ccccggaacc acttcagatg ccaggtgcag tttcacggcc tgagcgaaga ggacaagtgg     720

cctgagggca gccccaagcc cgtgactcag aatatctctg ccgaggcatg gggcagagcc     780

gactgtggca ttaccagcgc cagctaccat cagggcgtgc tgagcgccac catcctgtac     840

gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtcaggcct ggtgctgatg     900

gccatggtca agaagaagaa cagctga                                         927


<210> 94
<211> 1794
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3598 single chain nucleic acid TCR construct specific for
      HLA-DR4 epitope NY-ESO-1 116-135

<400> 94
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcggccaggg cgctggcacc     360

cagtattttg gccctggcac cagactgctg gtgctggaag atctgcggaa cgtgaccccc     420

cccaaggtgt ccctgttcga gcctagcaag gccgagatcg ccaacaagca gaaagccacc     480

ctcgtgtgcc tggccagagg cttcttcccc gaccacgtgg aactgtcttg gtgggtcaac     540

ggcaaagagg tgcacagcgg cgtgtccacc gatccccagg cctacaaaga gagcaactac     600

agctactgcc tgtccagcag actgcgggtg tccgccacct tctggcacaa cccccggaac     660

cacttcagat gccaggtgca gtttcacggc ctgagcgaag aggacaagtg gcctgagggc     720

agccccaagc ccgtgactca gaatatctct gccgaggcat ggggcagagc cgactgtggc     780

attaccagcg ccagctacca tcagggcgtg ctgagcgcca ccatcctgta cgagatcctg     840

ctgggcaagg ccaccctgta cgccgtgctg gtgtcaggcc tggtgctgat ggccatggtc     900

aagaagaaga acagcggcag cggcgccacc aactttagtc tgctgaaaca ggccggcgac     960

gtggaagaga accctggccc catgatgaag tccctgcggg tgctgctcgt gatcctgtgg    1020

ctgcagctga gctgggtgtg gtcccagcag aaagaggtgg aacaggaccc aggccctctg    1080

agcgtgccag agggcgctat cgtgtccctg aattgcacct acagcaacag cgccttccag    1140

tacttcatgt ggtatcggca gtacagccgg aagggccccg agctgctgat gtacacctac    1200

tccagcggca acaaagagga cggccggttc acagcccagg tggacaagag cagcaagtac    1260

atctccctgt tcatccggga cagccagccc agcgacagcg ccacatatct gtgcgccatg    1320

agacagggcg gctccgagaa gctggtgttc ggcaagggca caaagctgac cgtgaacccc    1380

tacatccaga accccgagcc cgccgtgtac cagctgaagg accctagaag ccaggacagc    1440

accctgtgcc tgttcaccga cttcgacagc cagatcaacg tgcccaagac catggaaagc    1500

ggcaccttca tcaccgacaa gaccgtgctg gacatgaagg ccatggacag caagagcaac    1560

ggcgccattg cctggtccaa ccagaccagc ttcacatgcc aggacatctt caaagagaca    1620

aacgccacct accccagcag cgacgtgccc tgtgatgcca ccctgaccga gaagtctttc    1680

gagacagaca tgaacctgaa cttccagaac ctgagcgtga tgggcctgag aatcctgctg    1740

ctgaaagtgg ccggattcaa cctgctgatg accctgcggc tgtggtccag ctga          1794


<210> 95
<211> 1800
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3598_2 single chain nucleic acid TCR construct specific for
      HLA-DR4 epitope NY-ESO-1 116-135

<400> 95
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcgtgatgac cggcctgaac     360

accgaggcat tctttgggca gggcacccgg ctgaccgtgg tggaagatct gagaaacgtg     420

acccccccca aggtgtccct gttcgagcct agcaaggccg agatcgccaa caagcagaaa     480

gccaccctcg tgtgcctggc cagaggcttc ttccccgacc acgtggaact gtcttggtgg     540

gtcaacggca aagaggtgca cagcggcgtg tccaccgatc cccaggccta caaagagagc     600

aactacagct actgcctgtc cagcagactg cgggtgtccg ccaccttctg gcacaacccc     660

cggaaccact tcagatgcca ggtgcagttt cacggcctga gcgaagagga caagtggcct     720

gagggcagcc ccaagcccgt gactcagaat atctctgccg aggcatgggg cagagccgac     780

tgtggcatta ccagcgccag ctaccatcag ggcgtgctga gcgccaccat cctgtacgag     840

atcctgctgg gcaaggccac cctgtacgcc gtgctggtgt ctggcctggt gctgatggcc     900

atggtcaaga agaagaacag cggcagcggc gccaccaact ttagtctgct gaaacaggcc     960

ggcgacgtgg aagagaaccc tggccccatg aactactctc ccggcctggt gtctctgatt    1020

ctgctgctgc tgggccggac cagaggcgat tctgtgaccc agatggaagg ccccgtgacc    1080

ctgagcgagg aagccttcct gaccatcaat tgcacctaca ccgccaccgg ctaccccagc    1140

ctgttttggt acgtgcagta ccccggcgag ggcctgcagc tgctgctgaa agccaccaag    1200

gccgacgaca agggcagcaa caagggcttc gaggccacct accggaaaga gacaaccagc    1260

ttccacctgg aaaagggcag cgtgcaggtg tccgactccg ccgtgtattt ctgcgccctg    1320

agagattctg gcggcggagc cgatggcctg acctttggca agggcacaca cctgatcatc    1380

cagccctaca tccagaaccc cgagcctgcc gtgtaccagc tgaaggaccc tagaagccag    1440

gacagcaccc tgtgcctgtt caccgacttc gacagccaga tcaacgtgcc caagaccatg    1500

gaaagcggca ccttcatcac cgacaagacc gtgctggaca tgaaggccat ggacagcaag    1560

agcaacggcg ccattgcctg gtccaaccag accagcttca catgccagga catcttcaaa    1620

gagactaacg ccacataccc cagcagcgac gtgccctgtg atgccaccct gaccgagaag    1680

tctttcgaga cagacatgaa cctgaacttc cagaacctga gcgtgatggg cctgagaatc    1740

ctgctgctga aggtggccgg cttcaacctg ctgatgaccc tgagactgtg gtccagctga    1800


<210> 96
<211> 1794
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412 single chain nucleic acid TCR construct specific for
      HLA-DR4 epitope NY-ESO-1 116-135

<400> 96
atgggaacat ctctgctgtg ttggatggcc ctgtgcctgc tgggagccga tcatgccgat      60

acaggcgtgt cccaggaccc ccggcacaag attaccaagc ggggccagaa cgtgaccttc     120

agatgcgacc ccatcagcga gcacaaccgg ctgtactggt acagacagac cctgggccag     180

ggccccgagt tcctgaccta cttccagaac gaggcccagc tggaaaagag ccggctgctg     240

agcgacagat tcagcgccga aagacccaag ggcagcttca gcaccctgga aatccagcgg     300

accgagcagg gcgacagcgc catgtatctg tgtgccagca gcctggaccg gccctacaac     360

gagcagttct ttggcccagg cacccggctg accgtgctgg aagatctgag aaacgtgacc     420

ccccccaagg tgtccctgtt cgagcctagc aaggccgaga tcgccaacaa gcagaaagcc     480

accctcgtgt gcctggccag aggcttcttc cccgaccacg tggaactgtc ttggtgggtc     540

aacggcaaag aggtgcacag cggcgtgtcc accgatcccc aggcctacaa agagagcaac     600

tacagctact gcctgagcag cagactgcgg gtgtccgcca ccttctggca caacccccgg     660

aaccacttca ggtgccaggt gcagtttcac ggcctgagcg aagaggacaa gtggcccgag     720

ggcagcccta agcccgtgac ccagaatatc tctgccgaag cctggggcag agccgactgt     780

ggcattacca gcgccagcta ccatcagggc gtgctgagcg ccaccatcct gtacgagatc     840

ctgctgggca aggccaccct gtacgccgtg ctggtgtctg gcctggtgct gatggccatg     900

gtcaagaaga agaacagcgg cagcggcgcc accaacttca gcctgctgaa acaggccggc     960

gacgtggaag agaaccctgg ccctatgctc ctgctgctgg tgcctgcctt ccaagtgatc    1020

ttcaccctgg gcggcaccag agcccagagc gtgacacagc tggatagcca ggtgcccgtg    1080

ttcgaagagg cccctgtgga actgcggtgc aactactcca gcagcgtgtc cgtgtacctg    1140

ttttggtacg tgcagtaccc caaccagggc ctgcagctgc tgctgaagta cctgagcggc    1200

tccaccctgg tggaatccat caacggcttc gaggccgagt tcaacaagag ccagaccagc    1260

ttccacctga gaaagcccag cgtgcacatc agcgataccg ccgagtactt ctgcgccgtg    1320

accctgaacc gggacgacaa gatcatcttc ggcaagggca ccagactgca catcctgccc    1380

aacatccaga accccgagcc cgccgtgtac cagctgaagg accctagaag ccaggatagc    1440

accctgtgtc tgttcaccga cttcgacagc cagatcaacg tgcccaagac catggaaagc    1500

ggcaccttca tcaccgacaa gacagtgctg gacatgaagg ccatggacag caagagcaac    1560

ggcgccattg cctggtccaa ccagacaagc ttcacatgcc aggacatctt caaagagaca    1620

aacgccacct accccagctc cgacgtgccc tgtgatgcca ccctgaccga gaagtccttc    1680

gagacagaca tgaacctgaa tttccagaac ctgagcgtga tgggcctgcg gatcctgctg    1740

ctgaaagtgg ccggcttcaa cctgctgatg accctgagac tgtggtccag ctga          1794


<210> 97
<211> 1800
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412_2 single chain nucleic acid TCR construct specific for
      HLA-DR4 epitope NY-ESO-1 116-135

<400> 97
atggatagct ggaccttttg ctgcgtgtcc ctgtgcatcc tggtggccaa gcacacagat      60

gccggcgtga tccagagccc cagacacgaa gtgaccgaga tgggccagga agtgaccctg     120

cgctgcaagc ctatcagcgg ccacaacagc ctgttctggt acagacagac catgatgcgg     180

ggcctggaac tgctgatcta cttcaacaac aacgtgccca tcgacgacag cggcatgccc     240

gaggatagat tcagcgccaa gatgcccaac gccagcttca gcaccctgaa gatccagccc     300

agcgagccca gagacagcgc cgtgtacttt tgcgccagca gctttctggc cagcgtgggc     360

tacgagcagt acttcggccc tggcaccaga ctgaccgtga ccgaggacct gagaaacgtg     420

acccccccca aagtgtctct gttcgagccc agcaaggccg agatcgccaa caagcagaaa     480

gccaccctcg tgtgcctggc cagaggcttc ttccccgacc acgtggaact gtcttggtgg     540

gtcaacggca aagaggtgca cagcggcgtg tccaccgatc cccaggccta caaagagagc     600

aactacagct actgcctgag cagcagactg cgggtgtccg ccaccttctg gcacaacccc     660

cggaaccact tcagatgcca ggtgcagttt cacggcctga gcgaagagga caagtggccc     720

gagggcagcc ctaagcccgt gacccagaat atctctgccg aagcctgggg cagagccgac     780

tgtggcatta ccagcgccag ctaccatcag ggcgtgctga gcgccaccat cctgtacgag     840

atcctgctgg gcaaggccac cctgtacgcc gtgctggtgt ctggcctggt gctgatggcc     900

atggtcaaga agaagaacag cggcagcggc gccaccaact tcagcctgct gaaacaggcc     960

ggcgacgtgg aagagaaccc tggccctatg ctcctgctgc tggtgcctgc cttccaagtg    1020

atcttcaccc tgggcggcac cagggcccag tctgtgacac agctggatag ccaggtgccc    1080

gtgttcgaag aggcccctgt ggaactgcgg tgcaactact ccagcagcgt gtccgtgtac    1140

ctgttttggt acgtgcagta ccccaaccag ggcctgcagc tgctgctgaa gtacctgagc    1200

ggctccaccc tggtggaatc catcaacggc ttcgaggccg agttcaacaa gagccagacc    1260

agcttccatc tgcggaagcc cagcgtgcac atcagcgata ccgccgagta cttctgtgcc    1320

gtgacccgga actccggcaa cacccctctg gtgtttggca agggcacacg gctgagcgtg    1380

atcgccaata tccagaaccc cgagcctgcc gtgtaccagc tgaaggaccc cagaagccag    1440

gatagcaccc tgtgcctgtt caccgacttc gacagccaga tcaatgtgcc caagaccatg    1500

gaaagcggca ccttcatcac cgacaagacc gtgctggaca tgaaggccat ggacagcaag    1560

agcaacggcg ccattgcctg gtccaaccag acaagcttca catgccagga catcttcaaa    1620

gagacaaacg ccacctaccc cagctccgac gtgccctgtg atgccaccct gaccgagaag    1680

tccttcgaga cagacatgaa cctgaacttc cagaacctgt ccgtgatggg cctgcggatc    1740

ctgctgctga aagtggccgg cttcaacctg ctgatgaccc tgagactgtg gtccagctga    1800


<210> 98
<211> 1788
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5412_3 single chain nucleic acid TCR construct specific for
      HLA-DR4 epitope NY-ESO-1 116-135

<400> 98
atggatacca gagtgctgtg ctgcgccgtg atctgcctgc tgggagccgg actgtctaat      60

gccggcgtga tgcagaaccc cagacacctc gtgcggcgga gaggacagga agccagactg     120

cgctgcagcc ccatgaaggg ccacagccac gtgtactggt acagacagct gcccgaagag     180

ggcctgaagt tcatggtgta cctgcagaaa gagaacatca tcgacgagag cggcatgccc     240

aaagagcggt tcagcgccga gttccccaaa gagggcccca gcatcctgag aatccagcag     300

gtcgtgcggg gcgatagcgc cgcctacttt tgtgccagct ctccacctct gggcgagcag     360

tactttggcc ctggcaccag actgaccgtg accgaggacc tgagaaacgt gacccccccc     420

aaggtgtccc tgttcgagcc tagcaaggcc gagatcgcca acaagcagaa agccaccctc     480

gtgtgcctgg ccagaggctt cttccccgac cacgtggaac tgtcttggtg ggtcaacggc     540

aaagaggtgc acagcggcgt gtccaccgat ccccaggcct acaaagagag caactacagc     600

tactgcctga gcagcagact gcgggtgtcc gccaccttct ggcacaaccc ccggaaccac     660

ttcagatgcc aggtgcagtt tcacggcctg agcgaagagg acaagtggcc cgagggcagc     720

cctaagcccg tgacccagaa tatctctgcc gaagcctggg gcagagccga ctgtggcatt     780

accagcgcca gctaccatca gggcgtgctg agcgccacca tcctgtacga gatcctgctg     840

ggcaaggcca ccctgtacgc cgtgctggtg tctggcctgg tgctgatggc catggtcaag     900

aagaagaaca gcggcagcgg cgccaccaac ttcagcctgc tgaaacaggc cggcgacgtg     960

gaagagaacc ctggccctat gctgctggaa catctgctga tcatcctgtg gatgcagctg    1020

acctgggtgt ccggccagca gctgaatcag agcccccaga gcatgttcat ccaggaaggc    1080

gaggacgtgt ccatgaactg caccagcagc agcatcttca atacctggct gtggtacaag    1140

caggaccccg gcgaaggacc cgtgctgctg atcgccctgt acaaagccgg cgagctgacc    1200

agcaatggca ggctgacagc ccagttcggc attacccgga aggacagctt cctgaacatc    1260

agcgcctcca tccccagcga cgtgggcatc tatttctgcg ccggacagca gaactccggc    1320

ggctccaact acaagctgac cttcggcaag ggcacactgc tgacagtgaa ccccaacatc    1380

cagaaccccg agcccgccgt gtaccagctg aaggacccta gaagccagga cagcaccctg    1440

tgcctgttca ccgacttcga cagccagatc aacgtgccca agaccatgga aagcggcacc    1500

ttcatcaccg acaagaccgt gctggacatg aaggccatgg acagcaagag caacggcgca    1560

atcgcctggt ccaaccagac cagcttcaca tgccaggaca tcttcaaaga gacaaacgcc    1620

acctacccca gctccgacgt gccctgtgat gccaccctga ccgagaagtc cttcgagaca    1680

gacatgaacc tgaacttcca gaatctgagc gtgatgggcc tgcgcatcct gctgctgaag    1740

gtggccggct ttaacctgct gatgaccctg cggctgtggt ccagctga                 1788


<210> 99
<211> 1782
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR3600 single chain nucleic acid TCR construct specific for
      HLA-DR4 epitope NY-ESO-1 116-135

<400> 99
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcgtgatcta cgagcagtac     360

ttcggccctg gcacccggct gaccgtgacc gaggatctga gaaacgtgac cccccccaag     420

gtgtccctgt tcgagcctag caaggccgag atcgccaaca agcagaaagc caccctcgtg     480

tgcctggcca gaggcttctt ccccgaccac gtggaactgt cttggtgggt caacggcaaa     540

gaggtgcaca gcggcgtgtc caccgatccc caggcctaca aagagagcaa ctacagctac     600

tgcctgtcca gcagactgcg ggtgtccgcc accttctggc acaacccccg gaaccacttc     660

agatgccagg tgcagtttca cggcctgagc gaagaggaca agtggcctga gggcagcccc     720

aagcccgtga ctcagaatat ctctgccgag gcatggggca gagccgactg tggcattacc     780

agcgccagct accatcaggg cgtgctgagc gccaccatcc tgtacgagat cctgctgggc     840

aaggccaccc tgtacgccgt gctggtgtct ggcctggtgc tgatggccat ggtcaagaag     900

aagaacagcg gcagcggcgc caccaacttt agtctgctga aacaggccgg cgacgtggaa     960

gagaaccctg gccccatggt caaaatccgg cagttcctgc tggccatcct gtggctgcag    1020

ctgagctgtg tgtccgccgc caagaacgag gtggaacaga gcccccagaa cctgaccgct    1080

caggaaggcg agttcatcac catcaactgc agctacagcg tgggcatcag cgccctgcat    1140

tggctgcagc agcatcctgg cggaggcatc gtgtctctgt tcatgctgag cagcggaaag    1200

aagaagcacg gccggctgat cgccacaatc aacatccagg aaaagcacag cagcctgcac    1260

atcaccgcca gccaccctag agacagcgcc gtgtacatct gcgccgtgcc caatagcggc    1320

aacacccctc tggtgttcgg caagggcacc agactgagcg tgatcgccaa tatccagaac    1380

cccgagcctg ccgtgtacca gctgaaggac cctagaagcc aggacagcac cctgtgcctg    1440

ttcaccgact tcgacagcca gatcaacgtg cccaagacca tggaaagcgg caccttcatc    1500

accgacaaga ccgtgctgga catgaaggcc atggacagca agagcaacgg cgccattgcc    1560

tggtccaacc agaccagctt cacatgccag gacatcttca aagagacaaa cgccacctac    1620

cccagcagcg acgtgccctg tgatgccacc ctgaccgaga agtctttcga gacagacatg    1680

aacctgaact tccagaatct gtccgtgatg ggcctgagaa tcctgctgct gaaagtggcc    1740

ggattcaacc tgctgatgac cctgcggctg tggtccagct ga                       1782


<210> 100
<211> 1782
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5712 single chain nucleic acid TCR construct specific for
      HLA-DR4 epitope NY-ESO-1 116-135

<400> 100
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcatcatcta cgagcagtac     360

ttcggccctg gcacccggct gaccgtgacc gaggatctga gaaacgtgac cccccccaag     420

gtgtccctgt tcgagcctag caaggccgag atcgccaaca agcagaaagc caccctcgtg     480

tgcctggcca gaggcttctt ccccgaccac gtggaactgt cttggtgggt caacggcaaa     540

gaggtgcaca gcggcgtgtc caccgatccc caggcctaca aagagagcaa ctacagctac     600

tgcctgtcca gcagactgcg ggtgtccgcc accttctggc acaacccccg gaaccacttc     660

agatgccagg tgcagtttca cggcctgagc gaagaggaca agtggcctga gggcagcccc     720

aagcccgtga ctcagaatat ctctgccgag gcatggggca gagccgactg tggcattacc     780

agcgccagct accatcaggg cgtgctgagc gccaccatcc tgtacgagat cctgctgggc     840

aaggccaccc tgtacgccgt gctggtgtct ggcctggtgc tgatggccat ggtcaagaag     900

aagaacagcg gcagcggcgc caccaacttt agtctgctga aacaggccgg cgacgtggaa     960

gagaaccctg gccccatggt caaaatccgg cagttcctgc tggccatcct gtggctgcag    1020

ctgagctgtg tgtccgccgc caagaacgag gtggaacaga gcccccagaa cctgaccgct    1080

caggaaggcg agttcatcac catcaactgc agctacagcg tgggcatcag cgccctgcat    1140

tggctgcagc agcatcctgg cggaggcatc gtgtctctgt tcatgctgag cagcggaaag    1200

aagaagcacg gccggctgat cgccacaatc aacatccagg aaaagcacag cagcctgcac    1260

atcaccgcca gccaccctag agacagcgcc gtgtacatct gcgccgtgcc caatagcggc    1320

aacacccctc tggtgttcgg caagggcacc agactgagcg tgatcgccaa tatccagaac    1380

cccgagcctg ccgtgtacca gctgaaggac cctagaagcc aggacagcac cctgtgcctg    1440

ttcaccgact tcgacagcca gatcaacgtg cccaagacca tggaaagcgg caccttcatc    1500

accgacaaga ccgtgctgga catgaaggcc atggacagca agagcaacgg cgccattgcc    1560

tggtccaacc agaccagctt cacatgccag gacatcttca aagagacaaa cgccacctac    1620

cccagcagcg acgtgccctg tgatgccacc ctgaccgaga agtctttcga gacagacatg    1680

aacctgaact tccagaatct gtccgtgatg ggcctgagaa tcctgctgct gaaagtggcc    1740

ggattcaacc tgctgatgac cctgcggctg tggtccagct ga                       1782


<210> 101
<211> 1782
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5415 single chain nucleic acid TCR construct specific for
      HLA-DR4 epitope NY-ESO-1 116-135

<400> 101
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gcgtgtacta cgagcagtac     360

ttcggccctg gcacccggct gaccgtgacc gaggatctga gaaacgtgac cccccccaag     420

gtgtccctgt tcgagcctag caaggccgag atcgccaaca agcagaaagc caccctcgtg     480

tgcctggcca gaggcttctt ccccgaccac gtggaactgt cttggtgggt caacggcaaa     540

gaggtgcaca gcggcgtgtc caccgatccc caggcctaca aagagagcaa ctacagctac     600

tgcctgtcca gcagactgcg ggtgtccgcc accttctggc acaacccccg gaaccacttc     660

agatgccagg tgcagtttca cggcctgagc gaagaggaca agtggcctga gggcagcccc     720

aagcccgtga ctcagaatat ctctgccgag gcatggggca gagccgactg tggcattacc     780

agcgccagct accatcaggg cgtgctgagc gccaccatcc tgtacgagat cctgctgggc     840

aaggccaccc tgtacgccgt gctggtgtct ggcctggtgc tgatggccat ggtcaagaag     900

aagaacagcg gcagcggcgc caccaacttt agtctgctga aacaggccgg cgacgtggaa     960

gagaaccctg gccccatggt caaaatccgg cagttcctgc tggccatcct gtggctgcag    1020

ctgagctgtg tgtccgccgc caagaacgag gtggaacaga gcccccagaa cctgaccgct    1080

caggaaggcg agttcatcac catcaactgc agctacagcg tgggcatcag cgccctgcat    1140

tggctgcagc agcatcctgg cggaggcatc gtgtctctgt tcatgctgag cagcggaaag    1200

aagaagcacg gccggctgat cgccacaatc aacatccagg aaaagcacag cagcctgcac    1260

atcaccgcca gccaccctag agacagcgcc gtgtacatct gcgccgtgcc caatagcggc    1320

aacacccctc tggtgttcgg caagggcacc agactgagcg tgatcgccaa tatccagaac    1380

cccgagcctg ccgtgtacca gctgaaggac cctagaagcc aggacagcac cctgtgcctg    1440

ttcaccgact tcgacagcca gatcaacgtg cccaagacca tggaaagcgg caccttcatc    1500

accgacaaga ccgtgctgga catgaaggcc atggacagca agagcaacgg cgccattgcc    1560

tggtccaacc agaccagctt cacatgccag gacatcttca aagagacaaa cgccacctac    1620

cccagcagcg acgtgccctg tgatgccacc ctgaccgaga agtctttcga gacagacatg    1680

aacctgaact tccagaatct gtccgtgatg ggcctgagaa tcctgctgct gaaagtggcc    1740

ggattcaacc tgctgatgac cctgcggctg tggtccagct ga                       1782


<210> 102
<211> 1800
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR5713 single chain nucleic acid TCR construct specific for
      HLA-DR4 epitope NY-ESO-1 116-135

<400> 102
atggatactt ggctcgtgtg ctgggccatc ttcagcctgc tgaaggccgg actgaccgag      60

cccgaagtga cccagacacc tagccaccaa gtgacacaga tgggccagga agtgatcctg     120

cgctgcgtgc ccatcagcaa ccacctgtac ttctactggt acagacagat cctggggcag     180

aaagtggaat ttctggtgtc cttctacaac aacgagatca gcgagaagtc cgagatcttc     240

gacgaccagt tcagcgtgga acggcccgac ggcagcaact tcaccctgaa gatcagaagc     300

accaagctgg aagatagcgc catgtacttt tgcgccagca gctctggact ggccggcgtg     360

acaggcgagc tgttttttgg cgagggcagc agactgaccg tgctggaaga tctgcggaac     420

gtgacccccc ccaaggtgtc cctgttcgag cctagcaagg ccgagatcgc caacaagcag     480

aaagccaccc tcgtgtgcct ggccagaggc ttcttccccg accacgtgga actgtcttgg     540

tgggtcaacg gcaaagaggt gcacagcggc gtgtccaccg atccccaggc ctacaaagag     600

agcaactaca gctactgcct gtcctcccgg ctgagagtgt ccgccacctt ctggcacaac     660

ccccggaacc acttcagatg ccaggtgcag tttcacggcc tgagcgaaga ggacaagtgg     720

cctgagggca gccccaagcc cgtgactcag aatatctctg ccgaggcatg gggcagagcc     780

gactgtggca ttaccagcgc cagctaccat cagggcgtgc tgagcgccac catcctgtac     840

gagatcctgc tgggcaaggc caccctgtac gccgtgctgg tgtcaggcct ggtgctgatg     900

gccatggtca agaagaagaa cagcggcagc ggcgccacca actttagtct gctgaaacag     960

gccggcgacg tggaagagaa ccctggcccc atgaagacct tcgccggctt cagcttcctg    1020

ttcctgtggc tgcagctgga ctgcatgagc agaggcgagg acgtggaaca gagcctgttt    1080

ctgagcgtgc gcgagggcga cagcagcgtg atcaattgca cctacaccga cagctccagc    1140

acatacctgt actggtataa gcaggaaccc ggcgctggcc tgcagctgct gacctacatc    1200

ttctccaaca tggacatgaa gcaggaccag cggctgacag tgctgctgaa caagaaggac    1260

aagcacctga gcctgcggat cgccgatacc cagacaggcg actccgccat ctatttctgc    1320

gccgaggcca atcaggccgg caccgccctg atctttggca agggcacaac actgagcgtg    1380

tccagcaaca tccagaaccc cgagcccgcc gtgtaccagc tgaaggaccc tagaagccag    1440

gacagcaccc tgtgcctgtt caccgacttc gacagccaga tcaacgtgcc caagaccatg    1500

gaaagcggca ccttcatcac cgacaagact gtgctggata tgaaggccat ggacagcaag    1560

agcaacggcg ccattgcctg gtccaaccag accagcttca catgccagga catcttcaaa    1620

gagacaaacg ccacctaccc cagcagcgac gtgccctgtg atgccaccct gaccgagaag    1680

tctttcgaga cagacatgaa cctgaacttc cagaacctga gcgtgatggg cctgagaatc    1740

ctgctgctga aggtggccgg cttcaacctg ctgatgaccc tgagactgtg gtccagctga    1800


<210> 103
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> HLA-A2 epitope NY-ESO-1 157-165

<400> 103
Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   

<210> 104
<211> 133
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR alpha chain specific for HLA-A2 epitope NY-ESO-1 157-165,
      variable region

<400> 104
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      
Trp Val Trp Ser Gln Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln 
            20                  25                  30          
His Val Gln Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr 
        35                  40                  45              
Thr Leu Ser Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro 
    50                  55                  60                  
Val Phe Leu Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys 
65                  70                  75                  80  
Arg Leu Thr Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His 
                85                  90                  95      
Ile Thr Ala Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly 
            100                 105                 110         
Glu Gly Asn Tyr Gly Gln Asn Phe Val Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             
Ser Val Leu Pro Asp 
    130             

<210> 105
<211> 400
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR alpha chain specific for HLA-A2 epitope NY-ESO-1 157-165,
      variable region

<400> 105
atgaagagcc tgcgcgtgct gctggtcatc ctgtggctgc aattgtcttg ggtctggtca      60

caggggcagc aggtcatgca gattccacag tatcagcacg tccaggaggg ggaggacttc     120

actacatatt gtaacagctc caccacactg tcaaatatcc agtggtacaa gcagcgacca     180

ggaggacacc cagtgttcct gattcagctg gtgaagagcg gcgaggtcaa gaaacagaaa     240

agactgacct tccagtttgg cgaagccaag aaaaactcta gtctgcatat cacagctact     300

cagactaccg acgtcggcac ctacttttgc gcaggagagg gcaactatgg gcagaatttc     360

gtgtttgggc ctggaacaag gctgtctgtc ctgcccgata                           400


<210> 106
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR alpha chain specific for HLA-A2 epitope NY-ESO-1 157-165

<400> 106
Met Lys Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu Ser 
1               5                   10                  15      
Trp Val Trp Ser Gln Gly Gln Gln Val Met Gln Ile Pro Gln Tyr Gln 
            20                  25                  30          
His Val Gln Glu Gly Glu Asp Phe Thr Thr Tyr Cys Asn Ser Ser Thr 
        35                  40                  45              
Thr Leu Ser Asn Ile Gln Trp Tyr Lys Gln Arg Pro Gly Gly His Pro 
    50                  55                  60                  
Val Phe Leu Ile Gln Leu Val Lys Ser Gly Glu Val Lys Lys Gln Lys 
65                  70                  75                  80  
Arg Leu Thr Phe Gln Phe Gly Glu Ala Lys Lys Asn Ser Ser Leu His 
                85                  90                  95      
Ile Thr Ala Thr Gln Thr Thr Asp Val Gly Thr Tyr Phe Cys Ala Gly 
            100                 105                 110         
Glu Gly Asn Tyr Gly Gln Asn Phe Val Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             
Ser Val Leu Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 
Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 
Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     
Thr Asp Lys Cys Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         
Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             
Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 
Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 
Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 

<210> 107
<211> 810
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR alpha chain specific for HLA-A2 epitope NY-ESO-1 157-165

<400> 107
atgaagagcc tgcgcgtgct gctggtcatc ctgtggctgc aattgtcttg ggtctggtca      60

caggggcagc aggtcatgca gattccacag tatcagcacg tccaggaggg ggaggacttc     120

actacatatt gtaacagctc caccacactg tcaaatatcc agtggtacaa gcagcgacca     180

ggaggacacc cagtgttcct gattcagctg gtgaagagcg gcgaggtcaa gaaacagaaa     240

agactgacct tccagtttgg cgaagccaag aaaaactcta gtctgcatat cacagctact     300

cagactaccg acgtcggcac ctacttttgc gcaggagagg gcaactatgg gcagaatttc     360

gtgtttgggc ctggaacaag gctgtctgtc ctgcccgata ttcagaatcc cgaacctgcc     420

gtataccagc tgaaggaccc ccgatctcag gatagtactc tgtgcctgtt caccgacttt     480

gatagtcaga tcaatgtgcc taaaaccatg gaatccggaa cttttattac cgacaagtgc     540

gtgctggata tgaaagccat ggacagtaag tcaaacggcg ccatcgcttg gagcaatcag     600

acatccttca cttgccagga tatcttcaag gagaccaacg caacataccc atcctctgac     660

gtgccctgtg atgccaccct gacagagaag tctttcgaaa cagacatgaa cctgaatttt     720

cagaatctga gcgtgatggg cctgagaatc ctgctgctga aggtcgctgg gtttaatctg     780

ctgatgacac tgcggctgtg gtcctcatga                                      810


<210> 108
<211> 134
<212> PRT
<213> Homo sapiens

<220> 
<223> TCR beta chain specific for HLA-A2 epitope NY-ESO-1 157-165,
      variable region

<400> 108
Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      
Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          
Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              
Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  
Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  
Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      
Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         
Ser Asn Ile Ala Gly Gly Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             
Arg Leu Thr Val Leu Glu 
    130                 

<210> 109
<211> 400
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR beta chain specific for HLA-A2 epitope NY-ESO-1 157-165,
      variable region

<400> 109
atggggagct ggaccctgtg ttgtgtgagc ctgtgtatcc tggtggcaaa gcataccgac      60

gctggagtga ttcagagccc tagacatgaa gtgactgaaa tggggcagga ggtcaccctg     120

cgatgcaagc ccatctccgg acacgactac ctgttctggt atcggcagac aatgatgaga     180

ggcctggagc tgctgatcta ctttaacaat aacgtgccca tcgacgattc agggatgccc     240

gaagacaggt tcagcgcaaa gatgcctaat gccagctttt ccaccctgaa aatccagccc     300

tctgaacctc gcgatagtgc tgtgtacttc tgtgccagta atattgctgg cgggtataac     360

gagcagttct ttggaccagg caccagactg acagtcctgg                           400


<210> 110
<211> 309
<212> PRT
<213> Artificial Sequence

<220> 
<223> TCR beta chain specific for HLA-A2 epitope NY-ESO-1 157-165

<400> 110
Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      
Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          
Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              
Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  
Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  
Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      
Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         
Ser Asn Ile Ala Gly Gly Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr 
        115                 120                 125             
Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 
Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 
Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
            180                 185                 190         
Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             
Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 
Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 
Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     
Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         
Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             
Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 
Asn Ser Thr Gly Ala 
305                 

<210> 111
<211> 921
<212> DNA
<213> Artificial Sequence

<220> 
<223> TCR beat chain specific for HLA-A2 epitope NY-ESO-1 157-165

<400> 111
atggggagct ggaccctgtg ttgtgtgagc ctgtgtatcc tggtggcaaa gcataccgac      60

gctggagtga ttcagagccc tagacatgaa gtgactgaaa tggggcagga ggtcaccctg     120

cgatgcaagc ccatctccgg acacgactac ctgttctggt atcggcagac aatgatgaga     180

ggcctggagc tgctgatcta ctttaacaat aacgtgccca tcgacgattc agggatgccc     240

gaagacaggt tcagcgcaaa gatgcctaat gccagctttt ccaccctgaa aatccagccc     300

tctgaacctc gcgatagtgc tgtgtacttc tgtgccagta atattgctgg cgggtataac     360

gagcagttct ttggaccagg caccagactg acagtcctgg aagatctacg taacgtgaca     420

ccacccaaag tctcactgtt tgagcctagc aaggcagaaa ttgccaacaa gcagaaggcc     480

accctggtgt gcctggcaag agggttcttt ccagatcacg tggagctgtc ctggtgggtc     540

aacggcaaag aagtgcattc tggggtctgc accgaccccc aggcttacaa ggagagtaat     600

tactcatatt gtctgtcaag ccggctgaga gtgtccgcca cattctggca caaccctagg     660

aatcatttcc gctgccaggt ccagtttcac ggcctgagtg aggaagataa atggccagag     720

gggtcaccta agccagtgac acagaacatc agcgcagaag cctggggacg agcagactgt     780

ggcattacta gcgcctccta tcatcagggc gtgctgagcg ccactatcct gtacgagatt     840

ctgctgggaa aggccaccct gtatgctgtg ctggtctccg gcctggtgct gatggccatg     900

gtcaagaaaa agaactcttg a                                               921


<210> 112
<211> 1794
<212> DNA
<213> Artificial Sequence

<220> 
<223> single chain nucleic acid TCR construct specific for HLA-A2
      epitope NY-ESO-1 157-165

<400> 112
atggggagct ggaccctgtg ttgtgtgagc ctgtgtatcc tggtggcaaa gcataccgac      60

gctggagtga ttcagagccc tagacatgaa gtgactgaaa tggggcagga ggtcaccctg     120

cgatgcaagc ccatctccgg acacgactac ctgttctggt atcggcagac aatgatgaga     180

ggcctggagc tgctgatcta ctttaacaat aacgtgccca tcgacgattc agggatgccc     240

gaagacaggt tcagcgcaaa gatgcctaat gccagctttt ccaccctgaa aatccagccc     300

tctgaacctc gcgatagtgc tgtgtacttc tgtgccagta atattgctgg cgggtataac     360

gagcagttct ttggaccagg caccagactg acagtcctgg aagatctacg taacgtgaca     420

ccacccaaag tctcactgtt tgagcctagc aaggcagaaa ttgccaacaa gcagaaggcc     480

accctggtgt gcctggcaag agggttcttt ccagatcacg tggagctgtc ctggtgggtc     540

aacggcaaag aagtgcattc tggggtctgc accgaccccc aggcttacaa ggagagtaat     600

tactcatatt gtctgtcaag ccggctgaga gtgtccgcca cattctggca caaccctagg     660

aatcatttcc gctgccaggt ccagtttcac ggcctgagtg aggaagataa atggccagag     720

gggtcaccta agccagtgac acagaacatc agcgcagaag cctggggacg agcagactgt     780

ggcattacta gcgcctccta tcatcagggc gtgctgagcg ccactatcct gtacgagatt     840

ctgctgggaa aggccaccct gtatgctgtg ctggtctccg gcctggtgct gatggccatg     900

gtcaagaaaa agaactctgg gagtggagcc acaaatttct ctctgctgaa acaggctgga     960

gatgtggagg aaaaccccgg ccctatgaag agcctgcgcg tgctgctggt catcctgtgg    1020

ctgcaattgt cttgggtctg gtcacagggg cagcaggtca tgcagattcc acagtatcag    1080

cacgtccagg agggggagga cttcactaca tattgtaaca gctccaccac actgtcaaat    1140

atccagtggt acaagcagcg accaggagga cacccagtgt tcctgattca gctggtgaag    1200

agcggcgagg tcaagaaaca gaaaagactg accttccagt ttggcgaagc caagaaaaac    1260

tctagtctgc atatcacagc tactcagact accgacgtcg gcacctactt ttgcgcagga    1320

gagggcaact atgggcagaa tttcgtgttt gggcctggaa caaggctgtc tgtcctgccc    1380

gatattcaga atcccgaacc tgccgtatac cagctgaagg acccccgatc tcaggatagt    1440

actctgtgcc tgttcaccga ctttgatagt cagatcaatg tgcctaaaac catggaatcc    1500

ggaactttta ttaccgacaa gtgcgtgctg gatatgaaag ccatggacag taagtcaaac    1560

ggcgccatcg cttggagcaa tcagacatcc ttcacttgcc aggatatctt caaggagacc    1620

aacgcaacat acccatcctc tgacgtgccc tgtgatgcca ccctgacaga gaagtctttc    1680

gaaacagaca tgaacctgaa ttttcagaat ctgagcgtga tgggcctgag aatcctgctg    1740

ctgaaggtcg ctgggtttaa tctgctgatg acactgcggc tgtggtcctc atga          1794


