                         SEQUENCE LISTING

<110>  Board of Trustees of Michigan State University
       Spence, Dana
 
<120>  COMPOSITIONS AND METHODS FOR MEASURING C-PEPTIDE BINDING AND 
       DIAGNOSING IMMUNE-MEDIATED DISEASES

<130>  6550-000291-WO-POA

<150>  62/132,213
<151>  2015-03-12

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
1               5                   10                  15      


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln 
            20                  25                  30      


<210>  2
<211>  31
<212>  PRT
<213>  Sus scrofa

<400>  2

Glu Leu Glu Asp Pro Gln Val Glu Gln Thr Glu Leu Gly Met Gly Leu 
1               5                   10                  15      


Gly Ala Gly Gly Leu Gln Pro Leu Ala Leu Glu Met Ala Leu Gln 
            20                  25                  30      


<210>  3
<211>  26
<212>  PRT
<213>  Bos taurus

<400>  3

Glu Val Glu Gly Pro Gln Val Gly Ala Leu Glu Leu Ala Gly Gly Pro 
1               5                   10                  15      


Gly Ala Gly Gly Leu Glu Gly Pro Pro Gln 
            20                  25      


<210>  4
<211>  28
<212>  PRT
<213>  Gallus gallus

<400>  4

Asp Val Glu Gln Pro Leu Val Ser Ser Pro Leu Arg Gly Glu Ala Gly 
1               5                   10                  15      


Val Leu Pro Phe Gln Gln Glu Glu Tyr Glu Lys Val 
            20                  25              


<210>  5
<211>  31
<212>  PRT
<213>  Danio rerio

<400>  5

Asp Val Glu Pro Leu Leu Gly Phe Leu Pro Pro Lys Ser Ala Gln Glu 
1               5                   10                  15      


Thr Glu Val Ala Asp Phe Ala Phe Lys Asp His Ala Glu Leu Ile 
            20                  25                  30      


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6-His tag

<400>  6

His His His His His His 
1               5       


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hemagglutinin tag

<400>  7

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG tag

<400>  8

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  9
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  10
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  11
<211>  607
<212>  PRT
<213>  Bos taurus

<400>  11

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Leu Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Thr His Lys Ser Glu Ile Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu His Phe Lys Gly Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ser Gln Tyr Leu Gln Gln Cys Pro Phe Asp Glu His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Leu Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser His Ala Gly Cys Glu Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Glu Leu Cys Lys Val Ala Ser Leu Arg Glu Thr Tyr Gly Asp Met Ala 
            100                 105                 110         


Asp Cys Cys Glu Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Ser 
        115                 120                 125             


His Lys Asp Asp Ser Pro Asp Leu Pro Lys Leu Lys Pro Asp Pro Asn 
    130                 135                 140                 


Thr Leu Cys Asp Glu Phe Lys Ala Asp Glu Lys Lys Phe Trp Gly Lys 
145                 150                 155                 160 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
                165                 170                 175     


Leu Leu Tyr Tyr Ala Asn Lys Tyr Asn Gly Val Phe Gln Glu Cys Cys 
            180                 185                 190         


Gln Ala Glu Asp Lys Gly Ala Cys Leu Leu Pro Lys Ile Glu Thr Met 
        195                 200                 205             


Arg Glu Lys Val Leu Ala Ser Ser Ala Arg Gln Arg Leu Arg Cys Ala 
    210                 215                 220                 


Ser Ile Gln Lys Phe Gly Glu Arg Ala Leu Lys Ala Trp Ser Val Ala 
225                 230                 235                 240 


Arg Leu Ser Gln Lys Phe Pro Lys Ala Glu Phe Val Glu Val Thr Lys 
                245                 250                 255     


Leu Val Thr Asp Leu Thr Lys Val His Lys Glu Cys Cys His Gly Asp 
            260                 265                 270         


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
        275                 280                 285             


Asp Asn Gln Asp Thr Ile Ser Ser Lys Leu Lys Glu Cys Cys Asp Lys 
    290                 295                 300                 


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Lys Asp Ala 
305                 310                 315                 320 


Ile Pro Glu Asn Leu Pro Pro Leu Thr Ala Asp Phe Ala Glu Asp Lys 
                325                 330                 335     


Asp Val Cys Lys Asn Tyr Gln Glu Ala Lys Asp Ala Phe Leu Gly Ser 
            340                 345                 350         


Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Glu Tyr Ala Val Ser Val 
        355                 360                 365             


Leu Leu Arg Leu Ala Lys Glu Tyr Glu Ala Thr Leu Glu Glu Cys Cys 
    370                 375                 380                 


Ala Lys Asp Asp Pro His Ala Cys Tyr Ser Thr Val Phe Asp Lys Leu 
385                 390                 395                 400 


Lys His Leu Val Asp Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Asp 
                405                 410                 415     


Gln Phe Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Leu Ile Val 
            420                 425                 430         


Arg Tyr Thr Arg Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
        435                 440                 445             


Val Ser Arg Ser Leu Gly Lys Val Gly Thr Arg Cys Cys Thr Lys Pro 
    450                 455                 460                 


Glu Ser Glu Arg Met Pro Cys Thr Glu Asp Tyr Leu Ser Leu Ile Leu 
465                 470                 475                 480 


Asn Arg Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Glu Lys Val 
                485                 490                 495     


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
            500                 505                 510         


Ala Leu Thr Pro Asp Glu Thr Tyr Val Pro Lys Ala Phe Asp Glu Lys 
        515                 520                 525             


Leu Phe Thr Phe His Ala Asp Ile Cys Thr Leu Pro Asp Thr Glu Lys 
    530                 535                 540                 


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Leu Lys His Lys Pro 
545                 550                 555                 560 


Lys Ala Thr Glu Glu Gln Leu Lys Thr Val Met Glu Asn Phe Val Ala 
                565                 570                 575     


Phe Val Asp Lys Cys Cys Ala Ala Asp Asp Lys Glu Ala Cys Phe Ala 
            580                 585                 590         


Val Glu Gly Pro Lys Leu Val Val Ser Thr Gln Thr Ala Leu Ala 
        595                 600                 605         


<210>  12
<211>  583
<212>  PRT
<213>  Bos taurus

<400>  12

Asp Thr His Lys Ser Glu Ile Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Asp Glu His Val Lys Leu Val Asn Glu Leu Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser His Ala Gly Cys Glu Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Glu Leu Cys Lys Val Ala Ser Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Asp Met Ala Asp Cys Cys Glu Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Ser His Lys Asp Asp Ser Pro Asp Leu 
            100                 105                 110         


Pro Lys Leu Lys Pro Asp Pro Asn Thr Leu Cys Asp Glu Phe Lys Ala 
        115                 120                 125             


Asp Glu Lys Lys Phe Trp Gly Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
    130                 135                 140                 


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Asn Lys Tyr 
145                 150                 155                 160 


Asn Gly Val Phe Gln Glu Cys Cys Gln Ala Glu Asp Lys Gly Ala Cys 
                165                 170                 175     


Leu Leu Pro Lys Ile Glu Thr Met Arg Glu Lys Val Leu Ala Ser Ser 
            180                 185                 190         


Ala Arg Gln Arg Leu Arg Cys Ala Ser Ile Gln Lys Phe Gly Glu Arg 
        195                 200                 205             


Ala Leu Lys Ala Trp Ser Val Ala Arg Leu Ser Gln Lys Phe Pro Lys 
    210                 215                 220                 


Ala Glu Phe Val Glu Val Thr Lys Leu Val Thr Asp Leu Thr Lys Val 
225                 230                 235                 240 


His Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
                245                 250                 255     


Ala Asp Leu Ala Lys Tyr Ile Cys Asp Asn Gln Asp Thr Ile Ser Ser 
            260                 265                 270         


Lys Leu Lys Glu Cys Cys Asp Lys Pro Leu Leu Glu Lys Ser His Cys 
        275                 280                 285             


Ile Ala Glu Val Glu Lys Asp Ala Ile Pro Glu Asn Leu Pro Pro Leu 
    290                 295                 300                 


Thr Ala Asp Phe Ala Glu Asp Lys Asp Val Cys Lys Asn Tyr Gln Glu 
305                 310                 315                 320 


Ala Lys Asp Ala Phe Leu Gly Ser Phe Leu Tyr Glu Tyr Ser Arg Arg 
                325                 330                 335     


His Pro Glu Tyr Ala Val Ser Val Leu Leu Arg Leu Ala Lys Glu Tyr 
            340                 345                 350         


Glu Ala Thr Leu Glu Glu Cys Cys Ala Lys Asp Asp Pro His Ala Cys 
        355                 360                 365             


Tyr Ser Thr Val Phe Asp Lys Leu Lys His Leu Val Asp Glu Pro Gln 
    370                 375                 380                 


Asn Leu Ile Lys Gln Asn Cys Asp Gln Phe Glu Lys Leu Gly Glu Tyr 
385                 390                 395                 400 


Gly Phe Gln Asn Ala Leu Ile Val Arg Tyr Thr Arg Lys Val Pro Gln 
                405                 410                 415     


Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Ser Leu Gly Lys Val 
            420                 425                 430         


Gly Thr Arg Cys Cys Thr Lys Pro Glu Ser Glu Arg Met Pro Cys Thr 
        435                 440                 445             


Glu Asp Tyr Leu Ser Leu Ile Leu Asn Arg Leu Cys Val Leu His Glu 
    450                 455                 460                 


Lys Thr Pro Val Ser Glu Lys Val Thr Lys Cys Cys Thr Glu Ser Leu 
465                 470                 475                 480 


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Thr Pro Asp Glu Thr Tyr 
                485                 490                 495     


Val Pro Lys Ala Phe Asp Glu Lys Leu Phe Thr Phe His Ala Asp Ile 
            500                 505                 510         


Cys Thr Leu Pro Asp Thr Glu Lys Gln Ile Lys Lys Gln Thr Ala Leu 
        515                 520                 525             


Val Glu Leu Leu Lys His Lys Pro Lys Ala Thr Glu Glu Gln Leu Lys 
    530                 535                 540                 


Thr Val Met Glu Asn Phe Val Ala Phe Val Asp Lys Cys Cys Ala Ala 
545                 550                 555                 560 


Asp Asp Lys Glu Ala Cys Phe Ala Val Glu Gly Pro Lys Leu Val Val 
                565                 570                 575     


Ser Thr Gln Thr Ala Leu Ala 
            580             


<210>  13
<211>  615
<212>  PRT
<213>  Gallus gallus

<400>  13

Met Lys Trp Val Thr Leu Ile Ser Phe Ile Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Thr Ser Arg Asn Leu Gln Arg Phe Ala Arg Asp Ala Glu His Lys Ser 
            20                  25                  30          


Glu Ile Ala His Arg Tyr Asn Asp Leu Lys Glu Glu Thr Phe Lys Ala 
        35                  40                  45              


Val Ala Met Ile Thr Phe Ala Gln Tyr Leu Gln Arg Cys Ser Tyr Glu 
    50                  55                  60                  


Gly Leu Ser Lys Leu Val Lys Asp Val Val Asp Leu Ala Gln Lys Cys 
65                  70                  75                  80  


Val Ala Asn Glu Asp Ala Pro Glu Cys Ser Lys Pro Leu Pro Ser Ile 
                85                  90                  95      


Ile Leu Asp Glu Ile Cys Gln Val Glu Lys Leu Arg Asp Ser Tyr Gly 
            100                 105                 110         


Ala Met Ala Asp Cys Cys Ser Lys Ala Asp Pro Glu Arg Asn Glu Cys 
        115                 120                 125             


Phe Leu Ser Phe Lys Val Ser Gln Pro Asp Phe Val Gln Pro Tyr Gln 
    130                 135                 140                 


Arg Pro Ala Ser Asp Val Ile Cys Gln Glu Tyr Gln Asp Asn Arg Val 
145                 150                 155                 160 


Ser Phe Leu Gly His Phe Ile Tyr Ser Val Ala Arg Arg His Pro Phe 
                165                 170                 175     


Leu Tyr Ala Pro Ala Ile Leu Ser Phe Ala Val Asp Phe Glu His Ala 
            180                 185                 190         


Leu Gln Ser Cys Cys Lys Glu Ser Asp Val Gly Ala Cys Leu Asp Thr 
        195                 200                 205             


Lys Glu Ile Val Met Arg Glu Lys Ala Lys Gly Val Ser Val Lys Gln 
    210                 215                 220                 


Gln Tyr Phe Cys Gly Ile Leu Lys Gln Phe Gly Asp Arg Val Phe Gln 
225                 230                 235                 240 


Ala Arg Gln Leu Ile Tyr Leu Ser Gln Lys Tyr Pro Lys Ala Pro Phe 
                245                 250                 255     


Ser Glu Val Ser Lys Phe Val His Asp Ser Ile Gly Val His Lys Glu 
            260                 265                 270         


Cys Cys Glu Gly Asp Met Val Glu Cys Met Asp Asp Met Ala Arg Met 
        275                 280                 285             


Met Ser Asn Leu Cys Ser Gln Gln Asp Val Phe Ser Gly Lys Ile Lys 
    290                 295                 300                 


Asp Cys Cys Glu Lys Pro Ile Val Glu Arg Ser Gln Cys Ile Met Glu 
305                 310                 315                 320 


Ala Glu Phe Asp Glu Lys Pro Ala Asp Leu Pro Ser Leu Val Glu Lys 
                325                 330                 335     


Tyr Ile Glu Asp Lys Glu Val Cys Lys Ser Phe Glu Ala Gly His Asp 
            340                 345                 350         


Ala Phe Met Ala Glu Phe Val Tyr Glu Tyr Ser Arg Arg His Pro Glu 
        355                 360                 365             


Phe Ser Ile Gln Leu Ile Met Arg Ile Ala Lys Gly Tyr Glu Ser Leu 
    370                 375                 380                 


Leu Glu Lys Cys Cys Lys Thr Asp Asn Pro Ala Glu Cys Tyr Ala Asn 
385                 390                 395                 400 


Ala Gln Glu Gln Leu Asn Gln His Ile Lys Glu Thr Gln Asp Val Val 
                405                 410                 415     


Lys Thr Asn Cys Asp Leu Leu His Asp His Gly Glu Ala Asp Phe Leu 
            420                 425                 430         


Lys Ser Ile Leu Ile Arg Tyr Thr Lys Lys Met Pro Gln Val Pro Thr 
        435                 440                 445             


Asp Leu Leu Leu Glu Thr Gly Lys Lys Met Thr Thr Ile Gly Thr Lys 
    450                 455                 460                 


Cys Cys Gln Leu Gly Glu Asp Arg Arg Met Ala Cys Ser Glu Gly Tyr 
465                 470                 475                 480 


Leu Ser Ile Val Ile His Asp Thr Cys Arg Lys Gln Glu Thr Thr Pro 
                485                 490                 495     


Ile Asn Asp Asn Val Ser Gln Cys Cys Ser Gln Leu Tyr Ala Asn Arg 
            500                 505                 510         


Arg Pro Cys Phe Thr Ala Met Gly Val Asp Thr Lys Tyr Val Pro Pro 
        515                 520                 525             


Pro Phe Asn Pro Asp Met Phe Ser Phe Asp Glu Lys Leu Cys Ser Ala 
    530                 535                 540                 


Pro Ala Glu Glu Arg Glu Val Gly Gln Met Lys Leu Leu Ile Asn Leu 
545                 550                 555                 560 


Ile Lys Arg Lys Pro Gln Met Thr Glu Glu Gln Ile Lys Thr Ile Ala 
                565                 570                 575     


Asp Gly Phe Thr Ala Met Val Asp Lys Cys Cys Lys Gln Ser Asp Ile 
            580                 585                 590         


Asn Thr Cys Phe Gly Glu Glu Gly Ala Asn Leu Ile Val Gln Ser Arg 
        595                 600                 605             


Ala Thr Leu Gly Ile Gly Ala 
    610                 615 


<210>  14
<211>  592
<212>  PRT
<213>  Gallus gallus

<400>  14

Phe Ala Arg Asp Ala Glu His Lys Ser Glu Ile Ala His Arg Tyr Asn 
1               5                   10                  15      


Asp Leu Lys Glu Glu Thr Phe Lys Ala Val Ala Met Ile Thr Phe Ala 
            20                  25                  30          


Gln Tyr Leu Gln Arg Cys Ser Tyr Glu Gly Leu Ser Lys Leu Val Lys 
        35                  40                  45              


Asp Val Val Asp Leu Ala Gln Lys Cys Val Ala Asn Glu Asp Ala Pro 
    50                  55                  60                  


Glu Cys Ser Lys Pro Leu Pro Ser Ile Ile Leu Asp Glu Ile Cys Gln 
65                  70                  75                  80  


Val Glu Lys Leu Arg Asp Ser Tyr Gly Ala Met Ala Asp Cys Cys Ser 
                85                  90                  95      


Lys Ala Asp Pro Glu Arg Asn Glu Cys Phe Leu Ser Phe Lys Val Ser 
            100                 105                 110         


Gln Pro Asp Phe Val Gln Pro Tyr Gln Arg Pro Ala Ser Asp Val Ile 
        115                 120                 125             


Cys Gln Glu Tyr Gln Asp Asn Arg Val Ser Phe Leu Gly His Phe Ile 
    130                 135                 140                 


Tyr Ser Val Ala Arg Arg His Pro Phe Leu Tyr Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Ser Phe Ala Val Asp Phe Glu His Ala Leu Gln Ser Cys Cys Lys Glu 
                165                 170                 175     


Ser Asp Val Gly Ala Cys Leu Asp Thr Lys Glu Ile Val Met Arg Glu 
            180                 185                 190         


Lys Ala Lys Gly Val Ser Val Lys Gln Gln Tyr Phe Cys Gly Ile Leu 
        195                 200                 205             


Lys Gln Phe Gly Asp Arg Val Phe Gln Ala Arg Gln Leu Ile Tyr Leu 
    210                 215                 220                 


Ser Gln Lys Tyr Pro Lys Ala Pro Phe Ser Glu Val Ser Lys Phe Val 
225                 230                 235                 240 


His Asp Ser Ile Gly Val His Lys Glu Cys Cys Glu Gly Asp Met Val 
                245                 250                 255     


Glu Cys Met Asp Asp Met Ala Arg Met Met Ser Asn Leu Cys Ser Gln 
            260                 265                 270         


Gln Asp Val Phe Ser Gly Lys Ile Lys Asp Cys Cys Glu Lys Pro Ile 
        275                 280                 285             


Val Glu Arg Ser Gln Cys Ile Met Glu Ala Glu Phe Asp Glu Lys Pro 
    290                 295                 300                 


Ala Asp Leu Pro Ser Leu Val Glu Lys Tyr Ile Glu Asp Lys Glu Val 
305                 310                 315                 320 


Cys Lys Ser Phe Glu Ala Gly His Asp Ala Phe Met Ala Glu Phe Val 
                325                 330                 335     


Tyr Glu Tyr Ser Arg Arg His Pro Glu Phe Ser Ile Gln Leu Ile Met 
            340                 345                 350         


Arg Ile Ala Lys Gly Tyr Glu Ser Leu Leu Glu Lys Cys Cys Lys Thr 
        355                 360                 365             


Asp Asn Pro Ala Glu Cys Tyr Ala Asn Ala Gln Glu Gln Leu Asn Gln 
    370                 375                 380                 


His Ile Lys Glu Thr Gln Asp Val Val Lys Thr Asn Cys Asp Leu Leu 
385                 390                 395                 400 


His Asp His Gly Glu Ala Asp Phe Leu Lys Ser Ile Leu Ile Arg Tyr 
                405                 410                 415     


Thr Lys Lys Met Pro Gln Val Pro Thr Asp Leu Leu Leu Glu Thr Gly 
            420                 425                 430         


Lys Lys Met Thr Thr Ile Gly Thr Lys Cys Cys Gln Leu Gly Glu Asp 
        435                 440                 445             


Arg Arg Met Ala Cys Ser Glu Gly Tyr Leu Ser Ile Val Ile His Asp 
    450                 455                 460                 


Thr Cys Arg Lys Gln Glu Thr Thr Pro Ile Asn Asp Asn Val Ser Gln 
465                 470                 475                 480 


Cys Cys Ser Gln Leu Tyr Ala Asn Arg Arg Pro Cys Phe Thr Ala Met 
                485                 490                 495     


Gly Val Asp Thr Lys Tyr Val Pro Pro Pro Phe Asn Pro Asp Met Phe 
            500                 505                 510         


Ser Phe Asp Glu Lys Leu Cys Ser Ala Pro Ala Glu Glu Arg Glu Val 
        515                 520                 525             


Gly Gln Met Lys Leu Leu Ile Asn Leu Ile Lys Arg Lys Pro Gln Met 
    530                 535                 540                 


Thr Glu Glu Gln Ile Lys Thr Ile Ala Asp Gly Phe Thr Ala Met Val 
545                 550                 555                 560 


Asp Lys Cys Cys Lys Gln Ser Asp Ile Asn Thr Cys Phe Gly Glu Glu 
                565                 570                 575     


Gly Ala Asn Leu Ile Val Gln Ser Arg Ala Thr Leu Gly Ile Gly Ala 
            580                 585                 590         


<210>  15
<211>  607
<212>  PRT
<213>  Sus scrofa

<400>  15

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Thr Tyr Lys Ser Glu Ile Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Gln Tyr Phe Lys Gly Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ser Gln His Leu Gln Gln Cys Pro Tyr Glu Glu His Val 
    50                  55                  60                  


Lys Leu Val Arg Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Ile His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Ala Ile Pro Ser Leu Arg Glu His Tyr Gly Asp Leu Ala 
            100                 105                 110         


Asp Cys Cys Glu Lys Glu Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asn Asp Asn Pro Asp Ile Pro Lys Leu Lys Pro Asp Pro Val 
    130                 135                 140                 


Ala Leu Cys Ala Asp Phe Gln Glu Asp Glu Gln Lys Phe Trp Gly Lys 
145                 150                 155                 160 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
                165                 170                 175     


Leu Leu Tyr Tyr Ala Ile Ile Tyr Lys Asp Val Phe Ser Glu Cys Cys 
            180                 185                 190         


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Ile Glu His Leu 
        195                 200                 205             


Arg Glu Lys Val Leu Thr Ser Ala Ala Lys Gln Arg Leu Lys Cys Ala 
    210                 215                 220                 


Ser Ile Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ser Leu Ala 
225                 230                 235                 240 


Arg Leu Ser Gln Arg Phe Pro Lys Ala Asp Phe Thr Glu Ile Ser Lys 
                245                 250                 255     


Ile Val Thr Asp Leu Ala Lys Val His Lys Glu Cys Cys His Gly Asp 
            260                 265                 270         


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
        275                 280                 285             


Glu Asn Gln Asp Thr Ile Ser Thr Lys Leu Lys Glu Cys Cys Asp Lys 
    290                 295                 300                 


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Ala Lys Arg Asp Glu 
305                 310                 315                 320 


Leu Pro Ala Asp Leu Asn Pro Leu Glu His Asp Phe Val Glu Asp Lys 
                325                 330                 335     


Glu Val Cys Lys Asn Tyr Lys Glu Ala Lys His Val Phe Leu Gly Thr 
            340                 345                 350         


Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser Leu 
        355                 360                 365             


Leu Leu Arg Ile Ala Lys Ile Tyr Glu Ala Thr Leu Glu Asp Cys Cys 
    370                 375                 380                 


Ala Lys Glu Asp Pro Pro Ala Cys Tyr Ala Thr Val Phe Asp Lys Phe 
385                 390                 395                 400 


Gln Pro Leu Val Asp Glu Pro Lys Asn Leu Ile Lys Gln Asn Cys Glu 
                405                 410                 415     


Leu Phe Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Leu Ile Val 
            420                 425                 430         


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
        435                 440                 445             


Val Ala Arg Lys Leu Gly Leu Val Gly Ser Arg Cys Cys Lys Arg Pro 
    450                 455                 460                 


Glu Glu Glu Arg Leu Ser Cys Ala Glu Asp Tyr Leu Ser Leu Val Leu 
465                 470                 475                 480 


Asn Arg Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Glu Lys Val 
                485                 490                 495     


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
            500                 505                 510         


Ala Leu Thr Pro Asp Glu Thr Tyr Lys Pro Lys Glu Phe Val Glu Gly 
        515                 520                 525             


Thr Phe Thr Phe His Ala Asp Leu Cys Thr Leu Pro Glu Asp Glu Lys 
    530                 535                 540                 


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Leu Lys His Lys Pro 
545                 550                 555                 560 


His Ala Thr Glu Glu Gln Leu Arg Thr Val Leu Gly Asn Phe Ala Ala 
                565                 570                 575     


Phe Val Gln Lys Cys Cys Ala Ala Pro Asp His Glu Ala Cys Phe Ala 
            580                 585                 590         


Val Glu Gly Pro Lys Phe Val Ile Glu Ile Arg Gly Ile Leu Ala 
        595                 600                 605         


<210>  16
<211>  583
<212>  PRT
<213>  Sus scrofa

<400>  16

Asp Thr Tyr Lys Ser Glu Ile Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Gln Tyr Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln His Leu Gln 
            20                  25                  30          


Gln Cys Pro Tyr Glu Glu His Val Lys Leu Val Arg Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Ile His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Ser Leu 
65                  70                  75                  80  


Arg Glu His Tyr Gly Asp Leu Ala Asp Cys Cys Glu Lys Glu Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asn Asp Asn Pro Asp Ile 
            100                 105                 110         


Pro Lys Leu Lys Pro Asp Pro Val Ala Leu Cys Ala Asp Phe Gln Glu 
        115                 120                 125             


Asp Glu Gln Lys Phe Trp Gly Lys Tyr Leu Tyr Glu Ile Ala Arg Arg 
    130                 135                 140                 


His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Ile Ile Tyr 
145                 150                 155                 160 


Lys Asp Val Phe Ser Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys 
                165                 170                 175     


Leu Leu Pro Lys Ile Glu His Leu Arg Glu Lys Val Leu Thr Ser Ala 
            180                 185                 190         


Ala Lys Gln Arg Leu Lys Cys Ala Ser Ile Gln Lys Phe Gly Glu Arg 
        195                 200                 205             


Ala Phe Lys Ala Trp Ser Leu Ala Arg Leu Ser Gln Arg Phe Pro Lys 
    210                 215                 220                 


Ala Asp Phe Thr Glu Ile Ser Lys Ile Val Thr Asp Leu Ala Lys Val 
225                 230                 235                 240 


His Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg 
                245                 250                 255     


Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Thr Ile Ser Thr 
            260                 265                 270         


Lys Leu Lys Glu Cys Cys Asp Lys Pro Leu Leu Glu Lys Ser His Cys 
        275                 280                 285             


Ile Ala Glu Ala Lys Arg Asp Glu Leu Pro Ala Asp Leu Asn Pro Leu 
    290                 295                 300                 


Glu His Asp Phe Val Glu Asp Lys Glu Val Cys Lys Asn Tyr Lys Glu 
305                 310                 315                 320 


Ala Lys His Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser Arg Arg 
                325                 330                 335     


His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Ile Ala Lys Ile Tyr 
            340                 345                 350         


Glu Ala Thr Leu Glu Asp Cys Cys Ala Lys Glu Asp Pro Pro Ala Cys 
        355                 360                 365             


Tyr Ala Thr Val Phe Asp Lys Phe Gln Pro Leu Val Asp Glu Pro Lys 
    370                 375                 380                 


Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Lys Leu Gly Glu Tyr 
385                 390                 395                 400 


Gly Phe Gln Asn Ala Leu Ile Val Arg Tyr Thr Lys Lys Val Pro Gln 
                405                 410                 415     


Val Ser Thr Pro Thr Leu Val Glu Val Ala Arg Lys Leu Gly Leu Val 
            420                 425                 430         


Gly Ser Arg Cys Cys Lys Arg Pro Glu Glu Glu Arg Leu Ser Cys Ala 
        435                 440                 445             


Glu Asp Tyr Leu Ser Leu Val Leu Asn Arg Leu Cys Val Leu His Glu 
    450                 455                 460                 


Lys Thr Pro Val Ser Glu Lys Val Thr Lys Cys Cys Thr Glu Ser Leu 
465                 470                 475                 480 


Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Thr Pro Asp Glu Thr Tyr 
                485                 490                 495     


Lys Pro Lys Glu Phe Val Glu Gly Thr Phe Thr Phe His Ala Asp Leu 
            500                 505                 510         


Cys Thr Leu Pro Glu Asp Glu Lys Gln Ile Lys Lys Gln Thr Ala Leu 
        515                 520                 525             


Val Glu Leu Leu Lys His Lys Pro His Ala Thr Glu Glu Gln Leu Arg 
    530                 535                 540                 


Thr Val Leu Gly Asn Phe Ala Ala Phe Val Gln Lys Cys Cys Ala Ala 
545                 550                 555                 560 


Pro Asp His Glu Ala Cys Phe Ala Val Glu Gly Pro Lys Phe Val Ile 
                565                 570                 575     


Glu Ile Arg Gly Ile Leu Ala 
            580             


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  17

Glu Gly Ser Leu Gln 
1               5   


