SEQUENCE LISTING

<110>  Min-Shi Lee
 
<120>  HIGH-GROWTH ENTEROVIRUS 71 STRAINS AND VACCINES

<130>  

<150>  62/130,584
<151>  2015-03-09

<160>  10   

<170>  PatentIn version 3.5

<210>  1
<211>  2193
<212>  PRT
<213>  Enterovirus 71

<400>  1
Met Gly Ser Gln Val Ser Thr Gln Arg Ser Gly Ser His Glu Asn Ser 
1                5                  10                  15

Asn Ser Ala Thr Glu Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr
            20                  25                  30

Tyr Lys Asp Ser Tyr Ala Ala Thr Ala Gly Lys Gln Ser Leu Lys Gln 
        35                  40                  45

Asp Pro Asp Lys Phe Ala Asn Pro Val Lys Asp Ile Phe Thr Glu Met
    50                  55                  60       
      
Ala Ala Pro Leu Lys Ser Pro Ser Ala Glu Ala Cys Gly Tyr Ser Asp
65                  70                  75                  80

Arg Val Ala Gln Leu Thr Ile Gly Asn Ser Thr Ile Thr Thr Gln Glu 
                85                  90                  95

Ala Ala Asn Ile Ile Val Gly Tyr Gly Glu Trp Pro Ser Tyr Cys Ser 
            100                 105                 110

Asp Asp Asp Ala Thr Ala Val Asp Lys Pro Thr Arg Pro Asp Val Ser
        115                 120                 125

Val Asn Arg Phe Tyr Thr Leu Asp Thr Lys Leu Trp Glu Lys Ser Ser
    130                 135                 140       

Lys Gly Trp Tyr Trp Lys Phe Pro Asp Val Leu Thr Glu Thr Gly Val
145                 150                 155                 160

Phe Gly Gln Asn Ala Gln Phe His Tyr Leu Tyr Arg Ser Gly Phe Cys
                165                 170                 175

Ile His Val Gln Cys Asn Ala Ser Lys Phe His Gln Gly Ala Leu Leu
            180                 185                 190

Val Ala Ile Leu Pro Glu Tyr Val Ile Gly Thr Val Ala Gly Gly Thr
        195                 200                 205

Gly Thr Glu Asp Ser His Pro Pro Tyr Lys Gln Thr Gln Pro Gly Ala
    210                 215                 220       

Asp Gly Phe Glu Leu Gln His Pro Tyr Val Leu Asp Ala Gly Ile Pro
225                 230                 235                 240

Ile Ser Gln Leu Thr Ile Cys Pro His Gln Trp Ile Asn Leu Arg Thr
                245                 250                 255

Asn Asn Cys Ala Thr Ile Ile Val Pro Tyr Met Asn Thr Leu Pro Phe
            260                 265                 270

Asp Ser Ala Leu Asn His Cys Asn Phe Gly Leu Leu Val Val Pro Ile
        275                 280                 285

Ser Pro Leu Asp Phe Asp Gln Gly Ala Thr Pro Val Ile Pro Ile Ile
    290                 295                 300       

Thr Thr Leu Ala Pro Met Cys Ser Glu Phe Ala Gly Leu Arg Gln Ala
305                 310                 315                 320

Val Thr Gln Gly Phe Pro Thr Glu Pro Lys Pro Gly Thr Asn Gln Phe
                325                 330                 335

Leu Thr Thr Asp Asp Gly Val Ser Ala Pro Ile Leu Pro Asn Phe His
            340                 345                 350

Pro Thr Pro Cys Ile His Ile Pro Gly Glu Val Arg Asn Leu Leu Glu
        355                 360                 365

Leu Cys Gln Val Glu Thr Ile Leu Glu Val Asn Asn Val Pro Thr Asn
    370                 375                 380     

Ala Thr Ser Leu Met Glu Arg Leu Arg Phe Pro Val Ser Ala Gln Ala
385                 390                 395                 400

Gly Lys Gly Glu Leu Cys Ala Val Phe Arg Ala Asp Pro Gly Arg Asp
                405                 410                 415

Gly Pro Trp Gln Ser Thr Met Leu Gly Gln Leu Cys Gly Tyr Tyr Thr
            420                 425                 430

Gln Trp Ser Gly Ser Leu Glu Val Thr Phe Met Phe Thr Gly Ser Phe
        435                 440                 445

Met Ala Thr Gly Lys Met Leu Ile Ala Tyr Thr Pro Pro Gly Gly Pro
    450                 455                 460     

Leu Pro Lys Asp Arg Ala Thr Ala Met Leu Gly Thr His Val Ile Trp 
465                 470                 475                 480

Asp Phe Gly Leu Gln Ser Ser Val Thr Leu Val Ile Pro Trp Ile Ser 
                485                 490                 495

Asn Thr His Tyr Arg Ala His Ala Arg Asp Gly Val Phe Asp Tyr Tyr 
            500                 505                 510

Thr Thr Gly Leu Val Ser Ile Trp Tyr Gln Thr Asn Tyr Val Val Pro 
        515                 520                 525

Ile Gly Ala Pro Asn Thr Ala Tyr Ile Ile Ala Leu Ala Ala Ala Gln 
    530                 535                 540     

Lys Asn Phe Thr Met Lys Leu Cys Lys Asp Thr Ser His Ile Leu Gln 
545                 550                 555                 560

Thr Ala Ser Ile Gln Gly Asp Arg Val Ala Asp Val Ile Glu Ser Ser 
                565                 570                 575

Ile Gly Asp Ser Val Ser Arg Ala Leu Thr Gln Ala Leu Pro Ala Pro 
            580                 585                 590

Thr Gly Gln Asn Thr Gln Val Ser Ser His Arg Leu Asp Thr Gly Glu 
        595                 600                 605

Val Pro Ala Leu Gln Ala Ala Glu Ile Gly Ala Ser Ser Asn Thr Ser 
    610                 615                 620     

Asp Glu Ser Met Ile Glu Thr Arg Cys Val Leu Asn Ser His Ser Thr 
625                 630                 635                 640

Ala Glu Thr Thr Leu Asp Ser Phe Phe Ser Arg Ala Gly Leu Val Gly 
                645                 650                 655

Glu Ile Asp Leu Pro Leu Glu Gly Thr Thr Asn Pro Asn Gly Tyr Ala 
            660                 665                 670

Asn Trp Asp Ile Asp Ile Thr Gly Tyr Ala Gln Met Arg Arg Lys Val 
        675                 680                 685

Glu Leu Phe Thr Tyr Met Arg Phe Asp Ala Glu Phe Thr Phe Val Ala 
    690                 695                 700     

Cys Thr Pro Thr Gly Gln Val Val Pro Gln Leu Leu Gln Tyr Met Phe 
705                 710                 715                 720

Val Pro Pro Gly Ala Pro Lys Pro Asp Ser Arg Glu Ser Leu Ala Trp 
                725                 730                 735

Gln Thr Ala Thr Asn Pro Ser Val Phe Val Lys Leu Thr Asp Pro Pro 
            740                 745                 750

Ala Gln Val Ser Val Pro Phe Met Ser Pro Ala Ser Ala Tyr Gln Trp 
        755                 760                 765

Phe Tyr Asp Gly Tyr Pro Thr Phe Gly Glu His Lys Gln Glu Lys Asp 
    770                 775                 780     

Leu Glu Tyr Gly Ala Cys Pro Asn Asn Met Met Gly Thr Phe Ser Val 
785                 790                 795                 800

Arg Thr Val Gly Ser Ser Lys Ser Lys Tyr Pro Leu Val Val Arg Ile 
                805                  810                815

Tyr Met Arg Met Lys His Val Arg Ala Trp Ile Pro Arg Pro Met Arg 
            820                 825                 830

Asn Gln Asn Tyr Leu Phe Lys Ala Asn Pro Asn Tyr Ala Gly Asn Ser 
        835                 840                 845

Ile Lys Pro Thr Gly Thr Ser Arg Thr Ala Ile Thr Thr Leu Gly Lys 
    850                 855                 860     

Phe Gly Gln Gln Ser Gly Ala Ile Tyr Val Gly Asn Phe Arg Val Val 
865                 870                 875                 880

Asn Arg His Leu Ala Thr His Asn Asp Trp Ala Asn Leu Val Trp Glu 
                885                  890                895

Asp Ser Ser Arg Asp Leu Leu Val Ser Ser Thr Thr Ala Gln Gly Cys 
            900                 905                 910

Asp Ile Ile Ala Arg Cys Asp Cys Gln Thr Gly Val Tyr Tyr Cys Asn 
        915                 920                 925

Ser Lys Arg Lys His Tyr Pro Val Ser Phe Ser Lys Pro Ser Leu Ile 
    930                 935                 940     

Tyr Val Asp Ala Ser Glu Tyr Tyr Pro Ala Arg Tyr Gln Ser His Leu 
945                 950                 955                 960

Met Leu Ala Ala Gly His Ser Glu Pro Gly Asp Cys Gly Gly Ile Leu 
                965                  970                975

Arg Cys Gln His Gly Val Val Gly Ile Val Ser Thr Gly Gly Asn Gly 
            980                 985                 990

Leu Val Gly Phe Ala Asp Val Arg Asp Leu Leu Trp Leu Asp Glu Glu 
        995                1000                 1005

Ala Met Glu Gln Gly Val Ser Asp Tyr Ile Lys Gly Leu Gly Asp Ala 
    1010                1015                1020     

Phe Gly Thr Gly Phe Thr Asp Ala Val Ser Arg Glu Val Glu Ala Leu 
1025                1030               1035                1040

Arg Asn His Leu Ile Gly Ser Asp Gly Ala Val Glu Lys Ile Leu Lys 
                1045               1050                1055

Asn Leu Ile Lys Leu Ile Ser Ala Leu Val Ile Val Ile Arg Ser Asp 
            1060                1065                1070

Tyr Asp Met Val Thr Leu Thr Ala Thr Leu Ala Leu Ile Gly Cys His 
       1075                1080                 1085

Gly Ser Pro Trp Ala Trp Ile Lys Ala Lys Thr Ala Ser Ile Leu Gly 
    1090                1095               1100     

Ile Pro Ile Ala Gln Lys Gln Ser Ala Ser Trp Leu Lys Lys Phe Asn 
1105                1110                1115                1120

Asp Met Ala Ser Ala Ala Lys Gly Leu Glu Trp Ile Ser Asn Lys Ile 
                1125                1130                1135

Ser Lys Phe Ile Asp Trp Leu Arg Glu Lys Ile Val Pro Ala Ala Arg 
            1140                1145                1150

Glu Lys Ala Glu Phe Leu Thr Asn Leu Lys Gln Leu Pro Leu Leu Glu 
        1155                1160                1165

Asn Gln Ile Thr Asn Leu Glu Gln Ser Ala Ala Ser Gln Glu Asp Leu 
    1170                1175               1180     

Glu Ala Met Phe Gly Asn Val Ser Tyr Leu Ala His Phe Cys Arg Lys 
1185               1190                1195                1200

Phe Gln Pro Leu Tyr Ala Thr Glu Ala Lys Arg Val Tyr Val Leu Glu 
                1205               1210                1215

Lys Arg Met Asn Asn Tyr Met Gln Phe Lys Ser Lys His Arg Ile Glu 
            1220                1225                1230

Pro Val Cys Leu Ile Ile Arg Gly Ser Pro Gly Thr Gly Lys Ser Leu 
       1235                1240                 1245

Ala Thr Gly Ile Ile Ala Arg Ala Ile Ala Asp Lys Tyr His Ser Ser 
    1250                1255               1260     

Val Tyr Ser Leu Pro Pro Asp Pro Asp His Phe Asp Gly Tyr Lys Gln 
1265               1270                1275                1280

Gln Val Val Thr Val Met Asp Asp Leu Cys Gln Asn Pro Asp Gly Lys 
                1285               1290                1295

Asp Met Ser Leu Phe Cys Gln Met Val Ser Thr Val Asp Phe Ile Pro 
            1300                1305                1310

Pro Met Ala Ser Leu Glu Glu Lys Gly Val Ser Phe Thr Ser Lys Phe 
       1315                1320                 1325

Val Ile Ala Ser Thr Asn Ala Ser Asn Ile Ile Val Pro Thr Val Ser 
    1330                1335               1340     

Asp Ser Asp Ala Ile Arg Arg Arg Phe Phe Met Asp Cys Asp Ile Glu 
1345               1350                1355                1360

Val Thr Asp Ser Tyr Lys Thr Asp Leu Gly Arg Leu Asp Ala Gly Arg 
                1365               1370                1375

Ala Ala Lys Leu Cys Ser Glu Asn Asn Thr Ala Asn Phe Lys Arg Cys 
            1380                1385                1390

Ser Pro Leu Val Cys Gly Lys Ala Ile Gln Leu Arg Asp Arg Lys Ser 
       1395                1400                 1405

Lys Val Arg Tyr Ser Val Asp Thr Val Val Ser Glu Leu Ile Arg Glu 
    1410                1415               1420     

Tyr Asn Ser Arg Ser Ala Ile Gly Asn Thr Ile Glu Ala Leu Phe Gln 
1425               1430                1435                1440

Gly Pro Pro Lys Phe Arg Pro Ile Arg Ile Ser Leu Glu Glu Lys Pro 
                1445               1450                1455

Ala Pro Asp Ala Ile Ser Asp Leu Leu Ala Ser Val Asp Ser Glu Glu 
            1460                1465                1470

Val Arg Gln Tyr Cys Arg Asp Gln Gly Trp Ile Ile Pro Glu Thr Pro 
       1475                1480                 1485

Thr Asn Val Glu Arg His Leu Asn Arg Ala Val Leu Val Met Gln Ser 
    1490                1495               1500     

Ile Ala Thr Val Val Ala Val Val Ser Leu Val Tyr Val Ile Tyr Lys 
1505               1510                1515                1520

Leu Phe Ala Gly Phe Gln Gly Ala Tyr Ser Gly Ala Pro Lys Gln Val 
                1525               1530                1535

Leu Lys Lys Pro Val Leu Arg Thr Ala Thr Val Gln Gly Pro Ser Leu 
            1540                1545                1550

Asp Phe Ala Leu Ser Leu Leu Arg Arg Asn Ile Arg Gln Val Gln Thr 
       1555                1560                 1565

Asp Gln Gly His Phe Thr Met Leu Gly Val Arg Asp Arg Leu Ala Val 
    1570                1575               1580     

Leu Pro Arg His Ala Gln Pro Gly Lys Thr Ile Trp Val Glu His Lys 
1585               1590                1595                1600

Leu Val Asn Val Leu Asp Ala Val Glu Leu Val Asp Glu Gln Gly Val 
                1605               1610                1615

Asn Leu Glu Leu Thr Leu Val Thr Leu Asp Thr Asn Glu Lys Phe Arg 
            1620                1625                1630

Asp Val Thr Lys Phe Ile Pro Glu Thr Ile Ser Ala Ala Ser Asp Ala 
       1635                1640                 1645

Thr Leu Val Ile Asn Thr Glu His Met Pro Ser Met Phe Val Pro Val 
    1650                1655               1660     

Gly Asp Val Val Gln Tyr Gly Phe Leu Asn Leu Ser Gly Lys Pro Thr 
1665               1670                1675                1680

His Arg Thr Met Met Tyr Asn Phe Pro Thr Lys Ala Gly Gln Cys Gly 
                1685               1690                1695

Gly Val Val Thr Ser Val Gly Lys Ile Val Gly Ile His Ile Gly Gly 
            1700                1705                1710

Asn Gly Arg Gln Gly Phe Ala Cys Gly Leu Lys Lys Ser Tyr Phe Ala 
       1715                1720                 1725

Ser Met Gln Gly Glu Ile Gln Trp Val Lys Pro Asn Lys Glu Thr Gly 
    1730                1735               1740     

Arg Leu Asn Ile Asn Gly Pro Thr Arg Thr Lys Leu Glu Pro Ser Val 
1745               1750                1755                1760

Phe His Asp Val Phe Glu Gly Asn Lys Glu Pro Ala Val Leu Thr Ser 
                1765               1770                1775

Lys Asp Pro Arg Leu Glu Val Asp Phe Glu Gln Ala Leu Phe Ser Lys 
            1780                1785                1790

Tyr Val Gly Asn Val Leu His Glu Pro Asp Glu Tyr Val Thr Gln Ala 
       1795                1800                 1805

Ala Leu His Tyr Ala Asn Gln Leu Lys Gln Leu Asp Ile Asn Thr Ser 
    1810                1815               1820     

Lys Met Ser Met Glu Glu Ala Cys Tyr Gly Thr Glu Asn Leu Glu Ala 
1825               1830                1835                1840

Ile Asp Leu Cys Thr Ser Ala Gly Tyr Pro Tyr Ser Ala Leu Gly Ile 
                1845               1850                1855

Lys Lys Arg Asp Ile Leu Asn Pro Val Thr Arg Asp Val Ser Lys Met 
            1860                1865                1870

Lys Phe Tyr Met Asp Lys Tyr Gly Leu Asp Leu Pro Tyr Ser Thr Tyr 
       1875                1880                 1885

Val Lys Asp Glu Leu Arg Ser Leu Asp Lys Ile Lys Lys Gly Lys Ser 
    1890                1895               1900     

Arg Leu Ile Glu Ala Ser Ser Leu Asn Asp Ser Val Tyr Leu Arg Met 
1905               1910                1915                1920

Thr Phe Gly His Leu Tyr Glu Val Phe His Ala Asn Pro Gly Thr Val 
                1925               1930                1935

Thr Gly Ser Ala Val Gly Cys Asn Pro Asp Val Phe Trp Ser Lys Leu 
            1940                1945                1950

Pro Ile Leu Leu Pro Gly Ser Leu Phe Ala Phe Asp Tyr Ser Gly Tyr 
       1955                1960                 1965

Asp Ala Ser Leu Ser Pro Val Trp Phe Arg Ala Leu Glu Val Val Leu 
    1970                1975               1980     

Arg Glu Ile Gly Tyr Pro Glu Glu Ala Val Ser Leu Ile Glu Gly Ile 
1985               1990                1995                2000

Asn His Thr His His Val Tyr Arg Asn Lys Thr Tyr Cys Val Leu Gly 
                2005                2010                2015

Gly Met Pro Ser Gly Cys Ser Gly Thr Ser Ile Phe Asn Ser Met Ile 
            2020                2025                2030

Asn Asn Ile Ile Ile Arg Thr Leu Leu Ile Lys Thr Phe Lys Gly Ile 
       2035                2040                 2045

Asp Leu Asp Glu Leu Asn Met Val Ala Tyr Gly Asp Asp Val Leu Ala 
    2050                2055               2060     

Ser Tyr Pro Phe Pro Ile Asp Cys Leu Glu Leu Ala Lys Thr Gly Lys 
2065               2070                2075                2080

Glu Tyr Gly Leu Thr Met Thr Pro Ala Asp Lys Ser Pro Cys Phe Asn 
                2085                2090                2095

Glu Val Thr Trp Glu Asn Ala Thr Phe Leu Lys Arg Gly Phe Leu Pro 
            2100                2105                2110

Asp His Gln Phe Pro Phe Leu Ile His Pro Thr Met Pro Met Arg Glu 
       2115                2120                 2125

Ile His Glu Ser Ile Arg Trp Thr Lys Asp Ala Arg Asn Thr Gln Asp 
    2130                2135               2140     

His Val Arg Ser Leu Cys Leu Leu Ala Trp His Asn Gly Lys Asp Glu 
2145               2150                2155                2160

Tyr Glu Lys Phe Val Ser Thr Ile Arg Ser Val Pro Val Gly Lys Ala 
                2165                2170                2175

Leu Ala Ile Pro Asn Phe Glu Asn Leu Arg Arg Asn Trp Leu Glu Leu 
            2180                2185                2190

Phe


<210>  2
<211>  7415
<212>  DNA
<213>  Enterovirus 71

<400>  2

ttaaaacagc ctgtgggttg cacccactca caggacccac gtggtgctag cactctggtt	60	   

ctacggaacc tttgtgcgcc tgttttacgc cccctcccca atttgtaact tagaagcaat	120 

ttacaacact gatcaatagc aggcatggcg caccagctat gtcttgatca agcacttctg 	180

tttccccgga ccgagtatca atagactgtt cacacggttg aaggagaaag cgtccgttat	240

ccggctaact acttcgagaa acccagtagc gccattgaag ccgcagagtg tttcgctcca 	300

cacttccccc gtgtagatca ggtcgatgag tcactgcaat cctcacgggc gaccgtggca	360

gtggctgcgc tggcggcctg cctatggggc gacccatagg acgctctaat gtggacatgg 	420

tgcgaagagt ctattgagct agttagtagt cctccggccc ctgaatgcgg ctaatcctaa	480

ctgcggagca catgccttca atccagaggg tagtgtgtcg taatgggcaa ctctgcagcg	540

gaaccgacta ctttgggtgt ccgtgtttcc ttttattctc acattggctg cttatggtga	600

caattacaga attgttacca tatagctatt ggattggcca tccggtgtgc aatagagcta	660

ttatatacct atttgttggc tttataccac taaccttaaa atctgtaacc actctcgagt 	720

atatattaac cctcaataca atcaaacatg ggctcacagg tgtctaccca acgatccggc	780

tcccatgaaa actccaactc agccacagaa ggctccacta ttaattacac cactattaac	840

tattacaaag attcctatgc tgcgacagcg ggcaaacaga gcctcaaaca agaccctgat	900

aagtttgcta accctgtcaa ggacattttc actgaaatgg ctgcccctct aaagtctcca 	960

tccgctgaag cttgtggtta cagtgatcgc gtagcacaac tcaccatcgg aaactccacc	1020

attactacac aggaagcggc aaacatcata gtcggttatg gtgaatggcc ctcatactgc	1080

tccgatgacg acgctacagc ggtggataag ccaacgcgcc cagatgtttc cgtgaatagg 	1140

ttttatacat tggacactaa attgtgggaa aagtcatcca aggggtggta ttggaagttc	1200

cctgatgtac tgactgagac cggagtcttt ggccaaaacg cacagtttca ctatttatat	1260

agatcagggt tttgcatcca tgtgcaatgt aacgctagca agttccacca aggagcgctg	1320

ttagtcgcta tacttccaga atatgtcata gggacagtgg caggcggcac aggaacagag	1380

gacagtcacc ctccttacaa acaaacacaa ccaggtgccg acggttttga attgcagcac	1440

ccgtatgtgc tcgatgctgg gatccctata tcgcaattga caatatgccc ccatcaatgg	1500

atcaacctgc ggaccaataa ctgtgccaca ataatagtgc catatatgaa tacactgcct 	1560

tttgactctg ccctgaacca ttgcaatttt gggctgctgg tagtgcccat tagcccattg 	1620

gattttgacc aaggggcaac tccggttatc cctattacaa tcactctagc tccaatgtgc	1680

tctgagtttg ctggtctcag gcaggcagtc actcaaggct ttcccactga gccaaaacca	1740

gggacgaacc aattcttgac caccgatgat ggcgtctcag cacccattct gccaaatttc 	1800

catcccactc cgtgtattca catacccggt gaagtcagaa acctgctcga gttgtgtcaa	1860

gtggagacta ttcttgaggt caacaatgta cccaccaatg ctactagttt gatggaaaga	1920

ctacgattcc cggtgtccgc gcaagcgggg aaaggtgaat tgtgtgctgt gtttagggct 	1980

gaccctggaa gagacggtcc atggcagtca acgatgctgg gccagttgtg tggatactac 	2040

actcaatggt ccgggtcact agaggtcact ttcatgttca ccgggtcctt catggccacg	2100

ggtaagatgc tcatagctta tacacctcct ggtggcccct tacccaagga ccgggctaca	2160

gcaatgttgg gcacacatgt tatctgggac tttgggctac aatcatctgt cacccttgtg 	2220

ataccatgga tcagtaatac ccactacagg gcgcatgccc gagatggggt gtttgattac	2280

tataccacgg gactggtcag tatctggtat caaacaaatt acgtggtccc aataggggca	2340

cccaacacag cttacataat agcactggcg gcggcccaga agaattttac catgaaactg 	2400

tgcaaggaca ctagtcacat attacagaca gcctctattc agggagatag ggtggcagat 	2460

gtgatcgaga gctctatagg agacagtgtg agtagggcac tcacccaggc ccttccggca 	2520

cccacaggac aaaacacaca ggtgagcagc catcgattag acactggtga agttccagcg	2580

ctccaagctg ctgagatcgg ggcatcatcg aatactagtg atgagagtat gattgagaca	2640

cgatgcgtcc ttaactcaca cagcacagca gagactaccc tggacagttt tttcagcaga 	2700

gcaggtttgg taggagagat agacctccct ctagagggta ccaccaatcc aaatggttat	2760

gccaattggg atatagacat aactggttat gcgcaaatgc gcaggaaagt ggagctgttc 	2820

acctatatgc gctttgatgc ggaattcact ttcgttgcgt gcactcctac tggtcaggtt 	2880

gttccgcaac tactccagta tatgtttgtt ccccctggtg ctcctaaacc agattctaga	2940

gaatcacttg cttggcagac agccactaac ccttcagttt ttgtcaagtt aactgacccc	3000

ccggcacagg tctcagttcc gttcatgtca cccgcgagcg cctaccagtg gttttacgac	3060

gggtatccca cgtttggaga acacaaacaa gagaaagatc ttgaatatgg agcgtgtcct 	3120

aacaacatga tgggcacttt ctcggtgcgg accgtggggt cttcaaagtc caagtatcct	3180

ttggttgtca gaatatatat gagaatgaag catgtcagag catggatacc tcgcccgatg 	3240

cgcaaccaaa actacttgtt caaagccaac ccaaattacg ccggtaactc cattaaaccg 	3300

accggtacta gtcgtaccgc cattactacc cttggaaagt tcggccagca atctggggcc	3360

atctacgtgg gcaacttcag agtggttaat cgtcacctcg ctactcataa tgactgggca	3420

aacctcgttt gggaagacag ctcccgtgac ctattagtgt cgtctaccac cgcccagggc	3480

tgtgacataa ttgcacgctg tgactgtcaa acaggagtgt actattgtaa ctccaaaaga	3540

aagcactatc cagtcagctt ttctaaaccc agcctcatat acgtggatgc tagcgagtat	3600

taccctgcta gatatcaatc gcacctgatg ctcgcagcgg gccattctga gcccggcgac 	3660

tgcggaggca tcttaaggtg ccaacatggt gtagttggta tagtgtccac aggtggcaac 	3720

ggactcgttg gttttgctga tgtgagggac ctcttgtggt tagatgaaga agccatggag	3780

caaggtgtct ccgactacat taaggggctc ggtgatgcat ttgggacagg cttcaccgat	3840

gctgtgtcca gggaagttga agcccttagg aaccacctta taggatctga tggagcagtt	3900

gagaaaatcc taaagaacct tattaagttg atttcagcgt tagtgattgt gatcaggagt	3960

gattatgata tggttaccct cacagccact ttagccctga ttggttgcca tggtagtcct	4020

tgggcttgga tcaaagccaa gacagcatcc attttaggca tccctattgc ccagaagcag 	4080

agtgcttctt ggctaaagaa gttcaatgat atggcgagtg ccgccaaggg tttagagtgg 	4140

atatccaaca aaattagtaa gttcattgac tggctcagag agaagattgt cccagcagct	4200

agagagaaag cagaattctt aaccaacttg aagcaattgc cgctgttaga gaatcagatc	4260

acaaatttgg aacagtccgc tgcctcacaa gaggaccttg aagccatgtt tgggaacgtg	4320

tcatacctcg ctcatttctg tcgcaaattc caaccattat acgccacaga agctaagcgg	4380

gtctatgttc tagagaagag aatgaacaac tacatgcagt tcaagagcaa acaccgtatt	4440

gaacctgtat gtcttatcat tagaggctca ccaggcactg ggaagtccct tgcgaccggc 	4500

atcattgctc gggccatagc agataagtat cactctagtg tgtactcact tccaccagac 	4560

cctgaccatt ttgacgggta caaacagcaa gtagttacag ttatggatga tctgtgtcag	4620

aatcccgacg gcaaggatat gtcattattt tgccagatgg tgtccaccgt ggattttatc	4680

ccaccaatgg cttctcttga agaaaaggga gtttctttta catctaaatt tgttatcgca	4740

tccaccaacg ccagcaacat catagtgcct acagtgtctg actctgacgc catccgacgc	4800

aggtttttca tggattgcga cattgaggtg acggattcat acaaaacaga cttgggtaga	4860

ttagatgctg gacgggctgc taagttatgc tctgaaaaca acaccgcaaa cttcaaacga 	4920

tgcagccctc tagtgtgtgg gaaagctatt caacttagag acaggaagtc caaggtcagg 	4980

tacagcgtgg acacagtggt ctctgaactt attagagaat acaatagcag atctgctata	5040

ggcaacacaa ttgaagcact attccaaggc ccgcccaagt tcaggccaat tagaatcagt	5100

cttgaggaga agccagcccc agacgctatt agtgatctcc tcgctagtgt agacagcgag	5160

gaagtgcgcc aatattgtag ggatcaaggc tggatcatcc ctgaaactcc cactaatgtt	5220

gaacgacatc ttaacagagc agtactagtt atgcaatcca tcgctactgt ggtggcagtt	5280

gtctcactgg tgtatgtcat ttacaagctc tttgcggggt ttcaaggcgc gtattctgga 	5340

gctcccaagc aagtgctcaa gaaacccgtc ctccgcacgg caacagtaca gggtccaagt 	5400

ctcgactttg ctctatccct gctgagaaga aacatcaggc aagtccaaac agatcagggg	5460

cattttacca tgttaggtgt cagggatcgt ttagctgttc tcccacggca cgcacagccc	5520

gggaagacta tttgggtgga gcacaaactt gtgaacgtcc tcgacgcagt tgagctagtg 	5580

gatgagcagg gcgttaattt ggaactcaca ctggtgacac tagacaccaa tgaaaaattt	5640

agagatgtca ccaagttcat tccagagacc attagtgccg ctagtgatgc aactttagtg	5700

atcaatacag agcacatgcc atcaatgttt gtcccagtgg gggacgttgt gcagtatggg 	5760

ttcctgaacc ttagtggaaa gccaacacat aggaccatga tgtataattt ccctacaaaa 	5820

gcaggacaat gcggaggtgt ggtcacatca gtcggtaaga ttgttggtat tcacatcggc	5880

ggcaacgggc gccaagggtt ctgtgctggt ttgaagaaga gttacttcgc aagtatgcag	5940

ggtgagatcc aatgggtgaa gcctaacaaa gaaactggta ggctgaacat caatggacca	6000

actcgcacta agctggagcc tagtgtattt catgatgtgt ttgaaggcaa taaggaacca 	6060

gcggtcttaa caagtaaaga ccctagattg gaggtcgact ttgagcaagc cctgttttcc	6120

aagtatgtgg gcaatgtttt acatgagcca gatgaatacg tgacacaagc tgccctccac 	6180

tatgcgaacc aacttaaaca gttagacata aacactagca agatgagcat ggaagaagcg 	6240

tgctatggca ctgagaacct ggaagcaata gacctctgta ctagtgctgg atatccatac	6300

agcgcccttg gcatcaagaa aagagacatt ctcaaccccg taactaggga tgtgtctaag	6360

atgaaattct acatggacaa atacgggcta gatctgccat actccaccta cgtgaaggat	6420

gaacttagat ctctggataa aatcaagaaa gggaagtcac gcttgataga ggctagtagc 	6480

ttgaatgact ctgtctacct cagaatgacc tttgggcacc tttacgaggt atttcacgct	6540

aaccctggta ctgtgaccgg ttcggcagtg ggttgcaacc cagacgtgtt ttggagtaag 	6600

ctgccgatcc tactgcctgg gtcactcttt gcctttgatt actcagggta tgatgctagc 	6660

ctcagcccgg tatggtttag ggccttagaa gttgtgttac gggaaattgg gtatccagag	6720

gaggccgtgt ccctcataga aggaatcaac cacactcacc acgtgtaccg gaacaaaaca	6780

tactgtgtac ttggtggaat gccatcaggg tgttctggta cttccatctt caactcaatg	6840

atcaacaaca tcattattag aaccctccta ataaaaacct ttaagggaat agacctggat 	6900

gagttgaaca tggtggccta tggggacgac gtgttggcta gttatccctt tcctatcgat	6960

tgtcttgagt tggctaagac tggtaaggag tatggtttga ctatgacacc tgcagacaaa 	7020

tcaccctgtt tcaatgaagt gacatgggaa aatgctacct tcctcaagag agggttcttg 	7080

ccagaccacc aattcccatt cttaattcac cctacgatgc ccatgagaga gattcatgag	7140

tccattcgat ggactaaaga cgcacgcaat acccaagatc atgtgcgctc cctgtgtctg	7200

ttggcatggc acaacggtaa ggatgaatat gagaaatttg tgagtacaat tagatcagtc	7260

ccagttggaa aagcgttggc tattcctaat tttgagaatt tgagaagaaa ttggctcgaa	7320

ttattttaac agtacagctt aaagctgaac cccactagaa atctggtcgt gttaatgact	7380

agtgggggta aatttgttat aaccagaata gcaaa					7415


<210>  3
<211>  69
<212>  PRT
<213>  Enterovirus 71

<400>  3

Met Gly Ser Gln Val Ser Thr Gln Arg Ser Gly Ser His Glu Asn Ser 
1                5                  10                  15

Asn Ser Ala Thr Glu Gly Ser Thr Ile Asn Tyr Thr Thr Ile Asn Tyr
            20                  25                  30

Tyr Lys Asp Ser Tyr Ala Ala Thr Ala Gly Lys Gln Ser Leu Lys Gln 
        35                  40                  45

Asp Pro Asp Lys Phe Ala Asn Pro Val Lys Asp Ile Phe Thr Glu Met
    50                  55                  60       
      
Ala Ala Pro Leu Lys
65


<210>  4
<211>  207
<212>  DNA
<213>  Enterovirus 71

<400>  4

atgggctcac aggtgtctac ccaacgatcc ggctcccatg aaaactccaa ctcagccaca 	60

gaaggctcca ctattaatta caccactatt aactattaca aagattccta tgctgcgaca	120

gcgggcaaac agagcctcaa acaagaccct gataagtttg ctaaccctgt caaggacatt	180

ttcactgaaa tggctgcccc tctaaag						207


<210>  5
<211>  297
<212>  PRT
<213>  Enterovirus 71

<400>  5

Gly Asp Arg Val Ala Asp Val Ile Glu Ser Ser Ile Gly Asp Ser Val 
1                5                  10                  15

Ser Arg Ala Leu Thr Gln Ala Leu Pro Ala Pro Thr Gly Gln Asn Thr
            20                  25                  30          

Gln Val Ser Ser His Arg Leu Asp Thr Gly Glu Val Pro Ala Leu Gln
        35                  40                  45

Ala Ala Glu Ile Gly Ala Ser Ser Asn Thr Ser Asp Glu Ser Met Ile 
    50                  55                  60       

Glu Thr Arg Cys Val Leu Asn Ser His Ser Thr Ala Glu Thr Thr Leu
65                  70                  75                  80

Asp Ser Phe Phe Ser Arg Ala Gly Leu Val Gly Glu Ile Asp Leu Pro
                85                  90                  95

Leu Glu Gly Thr Thr Asn Pro Asn Gly Tyr Ala Asn Trp Asp Ile Asp
            100                 105                 110

Ile Thr Gly Tyr Ala Gln Met Arg Arg Lys Val Glu Leu Phe Thr Tyr
        115                 120                 125

Met Arg Phe Asp Ala Glu Phe Thr Phe Val Ala Cys Thr Pro Thr Gly 
    130                 135                 140     

Gln Val Val Pro Gln Leu Leu Gln Tyr Met Phe Val Pro Pro Gly Ala
145                 150                 155                 160

Pro Lys Pro Asp Ser Arg Glu Ser Leu Ala Trp Gln Thr Ala Thr Asn
                165                 170                 175

Pro Ser Val Phe Val Lys Leu Thr Asp Pro Pro Ala Gln Val Ser Val 
            180                 185                 190

Pro Phe Met Ser Pro Ala Ser Ala Tyr Gln Trp Phe Tyr Asp Gly Tyr
        195                 200                 205

Pro Thr Phe Gly Glu His Lys Gln Glu Lys Asp Leu Glu Tyr Gly Ala 
    210                 215                 220     

Cys Pro Asn Asn Met Met Gly Thr Phe Ser Val Arg Thr Val Gly Ser
225                 230                 235                 240

Ser Lys Ser Lys Tyr Pro Leu Val Val Arg Ile Tyr Met Arg Met Lys  
                245                 250                 255

His Val Arg Ala Trp Ile Pro Arg Pro Met Arg Asn Gln Asn Tyr Leu 
            260                 265                 270

Phe Lys Ala Asn Pro Asn Tyr Ala Gly Asn Ser Ile Lys Pro Thr Gly 
        275                 280                 285

Thr Ser Arg Thr Ala Ile Thr Thr Leu
    290                 295


<210>  6
<211>  891
<212>  DNA
<213>  Enterovirus 71

<400>  6

ggagataggg tggcagatgt gatcgagagc tctataggag acagtgtgag tagggcactc	60

acccaggccc ttccggcacc cacaggacaa aacacacagg tgagcagcca tcgattagac	120

actggtgaag ttccagcgct ccaagctgct gagatcgggg catcatcgaa tactagtgat 	180

gagagtatga ttgagacacg atgcgtcctt aactcacaca gcacagcaga gactaccctg 	240

gacagttttt tcagcagagc aggtttggta ggagagatag acctccctct agagggtacc 	300

accaatccaa atggttatgc caattgggat atagacataa ctggttatgc gcaaatgcgc	360

aggaaagtgg agctgttcac ctatatgcgc tttgatgcgg aattcacttt cgttgcgtgc	420

actcctactg gtcaggttgt tccgcaacta ctccagtata tgtttgttcc ccctggtgct 	480

cctaaaccag attctagaga atcacttgct tggcagacag ccactaaccc ttcagttttt 	540

gtcaagttaa ctgacccccc ggcacaggtc tcagttccgt tcatgtcacc cgcgagcgcc	600

taccagtggt tttacgacgg gtatcccacg tttggagaac acaaacaaga gaaagatctt	660

gaatatggag cgtgtcctaa caacatgatg ggcactttct cggtgcggac cgtggggtct	720

tcaaagtcca agtatccttt ggttgtcaga atatatatga gaatgaagca tgtcagagca	780

tggatacctc gcccgatgcg caaccaaaac tacttgttca aagccaaccc aaattacgcc	840

ggtaactcca ttaaaccgac cggtactagt cgtaccgcca ttactaccct t		891
   


<210>  7
<211>  86
<212>  PRT
<213>  Enterovirus 71

<400>  7

Gly Pro Pro Lys Phe Arg Pro Ile Arg Ile Ser Leu Glu Glu Lys Pro 
1                5                  10                  15

Ala Pro Asp Ala Ile Ser Asp Leu Leu Ala Ser Val Asp Ser Glu Glu 
            20                  25                  30          

Val Arg Gln Tyr Cys Arg Asp Gln Gly Trp Ile Ile Pro Glu Thr Pro 
        35                  40                  45

Thr Asn Val Glu Arg His Leu Asn Arg Ala Val Leu Val Met Gln Ser 
    50                  55                  60       

Ile Ala Thr Val Val Ala Val Val Ser Leu Val Tyr Val Ile Tyr Lys 
65                  70                  75                  80

Leu Phe Ala Gly Phe Gln
                85



<210>  8
<211>  258
<212>  DNA
<213>  Enterovirus 71

<400>  8

ggcccgccca agttcaggcc aattagaatc agtcttgagg agaagccagc cccagacgct	60

attagtgatc tcctcgctag tgtagacagc gaggaagtgc gccaatattg tagggatcaa	120

ggctggatca tccctgaaac tcccactaat gttgaacgac atcttaacag agcagtacta	180

gttatgcaat ccatcgctac tgtggtggca gttgtctcac tggtgtatgt catttacaag	240

ctctttgcgg ggtttcaa 							258



<210>  9
<211>  462
<212>  PRT
<213>  Enterovirus 71

<400>  9

Gly Glu Ile Gln Trp Val Lys Pro Asn Lys Glu Thr Gly Arg Leu Asn 
1                5                  10                  15

Ile Asn Gly Pro Thr Arg Thr Lys Leu Glu Pro Ser Val Phe His Asp 
            20                  25                  30         

Val Phe Glu Gly Asn Lys Glu Pro Ala Val Leu Thr Ser Lys Asp Pro 
        35                  40                  45

Arg Leu Glu Val Asp Phe Glu Gln Ala Leu Phe Ser Lys Tyr Val Gly 
    50                  55                  60

Asn Val Leu His Glu Pro Asp Glu Tyr Val Thr Gln Ala Ala Leu His 
65                  70                  75                  80

Tyr Ala Asn Gln Leu Lys Gln Leu Asp Ile Asn Thr Ser Lys Met Ser
                 85                  90                  95

Met Glu Glu Ala Cys Tyr Gly Thr Glu Asn Leu Glu Ala Ile Asp Leu 
            100                 105                 110         

Cys Thr Ser Ala Gly Tyr Pro Tyr Ser Ala Leu Gly Ile Lys Lys Arg 
        115                 120                 125

Asp Ile Leu Asn Pro Val Thr Arg Asp Val Ser Lys Met Lys Phe Tyr 
    130                 135                 140

Met Asp Lys Tyr Gly Leu Asp Leu Pro Tyr Ser Thr Tyr Val Lys Asp 
145                 150                 155                 160

Glu Leu Arg Ser Leu Asp Lys Ile Lys Lys Gly Lys Ser Arg Leu Ile 
                165                 170                 175

Glu Ala Ser Ser Leu Asn Asp Ser Val Tyr Leu Arg Met Thr Phe Gly 
            180                 185                 190        

His Leu Tyr Glu Val Phe His Ala Asn Pro Gly Thr Val Thr Gly Ser 
        195                 200                 205

Ala Val Gly Cys Asn Pro Asp Val Phe Trp Ser Lys Leu Pro Ile Leu 
    210                 215                 220

Leu Pro Gly Ser Leu Phe Ala Phe Asp Tyr Ser Gly Tyr Asp Ala Ser 
225                 230                 235                 240

Leu Ser Pro Val Trp Phe Arg Ala Leu Glu Val Val Leu Arg Glu Ile 
                245                 250                 255
    
Gly Tyr Pro Glu Glu Ala Val Ser Leu Ile Glu Gly Ile Asn His Thr 
            260                 265                 270        

His His Val Tyr Arg Asn Lys Thr Tyr Cys Val Leu Gly Gly Met Pro 
        275                 280                 285

Ser Gly Cys Ser Gly Thr Ser Ile Phe Asn Ser Met Ile Asn Asn Ile 
    290                 295                 300

Ile Ile Arg Thr Leu Leu Ile Lys Thr Phe Lys Gly Ile Asp Leu Asp 
305                 310                 315                 320

Glu Leu Asn Met Val Ala Tyr Gly Asp Asp Val Leu Ala Ser Tyr Pro 
                325                 330                 335  

Phe Pro Ile Asp Cys Leu Glu Leu Ala Lys Thr Gly Lys Glu Tyr Gly 
            340                 345                 350  

Leu Thr Met Thr Pro Ala Asp Lys Ser Pro Cys Phe Asn Glu Val Thr 
        355                 360                 365

Trp Glu Asn Ala Thr Phe Leu Lys Arg Gly Phe Leu Pro Asp His Gln 
    370                 375                 380

Phe Pro Phe Leu Ile His Pro Thr Met Pro Met Arg Glu Ile His Glu 
385                 390                 395                 400

Ser Ile Arg Trp Thr Lys Asp Ala Arg Asn Thr Gln Asp His Val Arg 
                405                 410                 415  

Ser Leu Cys Leu Leu Ala Trp His Asn Gly Lys Asp Glu Tyr Glu Lys 
            420                 425                 430  

Phe Val Ser Thr Ile Arg Ser Val Pro Val Gly Lys Ala Leu Ala Ile 
        435                 440                 445

Pro Asn Phe Glu Asn Leu Arg Arg Asn Trp Leu Glu Leu Phe 
    450                 455                 460

          




<210>  10
<211>  1386
<212>  DNA
<213>  Enterovirus 71

<400>  10

ggtgagatcc aatgggtgaa gcctaacaaa gaaactggta ggctgaacat caatggacca	60

actcgcacta agctggagcc tagtgtattt catgatgtgt ttgaaggcaa taaggaacca 	120

gcggtcttaa caagtaaaga ccctagattg gaggtcgact ttgagcaagc cctgttttcc	180

aagtatgtgg gcaatgtttt acatgagcca gatgaatacg tgacacaagc tgccctccac 	240

tatgcgaacc aacttaaaca gttagacata aacactagca agatgagcat ggaagaagcg 	300

tgctatggca ctgagaacct ggaagcaata gacctctgta ctagtgctgg atatccatac	360

agcgcccttg gcatcaagaa aagagacatt ctcaaccccg taactaggga tgtgtctaag	420

atgaaattct acatggacaa atacgggcta gatctgccat actccaccta cgtgaaggat	480

gaacttagat ctctggataa aatcaagaaa gggaagtcac gcttgataga ggctagtagc 	540

ttgaatgact ctgtctacct cagaatgacc tttgggcacc tttacgaggt atttcacgct	600

aaccctggta ctgtgaccgg ttcggcagtg ggttgcaacc cagacgtgtt ttggagtaag 	660

ctgccgatcc tactgcctgg gtcactcttt gcctttgatt actcagggta tgatgctagc 	720

ctcagcccgg tatggtttag ggccttagaa gttgtgttac gggaaattgg gtatccagag	780

gaggccgtgt ccctcataga aggaatcaac cacactcacc acgtgtaccg gaacaaaaca	840

tactgtgtac ttggtggaat gccatcaggg tgttctggta cttccatctt caactcaatg	900

atcaacaaca tcattattag aaccctccta ataaaaacct ttaagggaat agacctggat 	960

gagttgaaca tggtggccta tggggacgac gtgttggcta gttatccctt tcctatcgat	1020

tgtcttgagt tggctaagac tggtaaggag tatggtttga ctatgacacc tgcagacaaa 	1080

tcaccctgtt tcaatgaagt gacatgggaa aatgctacct tcctcaagag agggttcttg 	1140

ccagaccacc aattcccatt cttaattcac cctacgatgc ccatgagaga gattcatgag	1200

tccattcgat ggactaaaga cgcacgcaat acccaagatc atgtgcgctc cctgtgtctg	1260

ttggcatggc acaacggtaa ggatgaatat gagaaatttg tgagtacaat tagatcagtc	1320

ccagttggaa aagcgttggc tattcctaat tttgagaatt tgagaagaaa ttggctcgaa	1380

ttattt									1386


