                         SEQUENCE LISTING

<110>  The Research Foundation for The State University of New 
       York
 
<120>  KERATIN 17 AS A DIAGNOSTIC AND THERAPEUTIC TARGET FOR CANCER

<130>  31847

<150>  62/128,610
<151>  2015-03-05

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lysine rich keratin 17 nuclear localization signal


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  Xaa can be no amino acid or can be any naturally occurring amino 
       acid

<220>
<221>  misc_feature
<222>  (5)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys 
1               5                   10                  15      


<210>  2
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Arginine rich keratin 17 nuclear localization signal


<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  Xaa can be no amino acid or can be any naturally occurring amino 
       acid

<220>
<221>  misc_feature
<222>  (5)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Arg 
1               5                   10                  15      


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bipartite keratin 17 nuclear localization signal


<220>
<221>  misc_feature
<222>  (3)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Arg Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys 
1               5                   10                  15      


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  short bipartite keratin 17 nuclear localization signal


<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Arg Arg Leu Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Lys 
1               5                   10                  


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  complete bipartite keratin 17 nuclear localization signal

<400>  5

Arg Arg Leu Leu Glu Gly Glu Asp Ala His Leu Thr Gln Tyr Lys Lys 
1               5                   10                  15      


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variable leucine rich keratin 17 nuclear export signal


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Leu Xaa Xaa Leu Xaa Leu 
1               5       


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucine rich keratin 17 nuclear export signal

<400>  7

Leu Asp Glu Leu Thr Leu 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified leucine rich keratin 17 nuclear export signal

<400>  8

Leu Glu Glu Leu Glu Leu 
1               5       


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified leucine rich keratin 17 nuclear export signal

<400>  9

Leu Glu Arg Leu Thr Leu 
1               5       


<210>  10
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRAIL 1, p27 tumor suppressor variable binding domain of keratin 
       17


<220>
<221>  misc_feature
<222>  (2)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Arg Xaa Xaa Xaa Xaa Asp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu 
1               5                   10                  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRAIL 2, p27 tumor suppressor variable binding domain of keratin 
       17


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(12)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Arg Ala Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Glu 
1               5                   10                  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRAIL 1, p27 tumor suppressor binding domain of keratin 17

<400>  12

Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu 
1               5                   10                  


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRAIL 1, p27 tumor suppressor binding domain of keratin 17

<400>  13

Arg Ala Asp Leu Glu Met Ile Glu Asn Leu Lys Glu Glu 
1               5                   10              


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a short hairpin RNA molecule against keratin 17

<400>  14
agaaagaacc ggugaccac                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a short hairpin RNA molecule against keratin 17

<400>  15
cgucaggugc guaccauug                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a short hairpin RNA molecule against keratin 17

<400>  16
gguccaggau ggcaagguc                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  a short hairpin RNA molecule against keratin 17

<400>  17
ggagaggaug cccaccuga                                                    19


<210>  18
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SH1, a short hairpin RNA molecule against keratin 17

<400>  18
tcttgtactg agtcaggtg                                                    19


<210>  19
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SH2, a short hairpin RNA molecule against keratin 17

<400>  19
tctttcttgt actgagtca                                                    19


<210>  20
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SH3, a short hairpin RNA molecule against keratin 17

<400>  20
ctgtctcaaa cttggtgcg                                                    19


<210>  21
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRAIL 1, a modified peptide for p27 tumor suppressor binding 
       domain of keratin 17


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  amine (NH2)

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  amide or carbonyl (CONH2)

<400>  21

Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu Gln 
1               5                   10                  15      


Ala 
    


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRAIL 2, a modified peptide for p27 tumor suppressor binding 
       domain of keratin 17


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  amine (NH2)

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  amide or carbonyl (CONH2)

<400>  22

Ala Arg Ala Asp Leu Glu Met Gln Ile Glu Asn Leu Lys Glu Glu Leu 
1               5                   10                  15      


Ala 
    


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRAIL 1, p27 tumor suppressor binding domain of keratin 17

<400>  23

Ala Arg Leu Ala Ala Asp Asp Phe Arg Thr Lys Phe Glu Thr Glu Gln 
1               5                   10                  15      


Ala 
    


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MRAIL 2, p27 tumor suppressor binding domain of keratin 17

<400>  24

Ala Arg Ala Asp Leu Glu Met Gln Ile Glu Asn Leu Lys Glu Glu Leu 
1               5                   10                  15      


Ala 
    


