                         SEQUENCE LISTING

<110>  XOMA (US) LLC
       JOHNSON, et al.
 
<120>  TREATMENT OF POST-PRANDIAL HYPERINSULINEMIA AND HYPOGLYCEMIA 
       AFTER BARIATRIC SURGERY

<130>  27129/49303/PC

<150>  US-62/127,788
<151>  2015-03-03

<150>  US-62/288,955
<151>  2016-01-29

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Glu Trp Gly Phe Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  2
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  2

Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Thr Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Gln Gly Tyr Gly Tyr Arg Phe Thr Asp Asn 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Ala Pro Leu Ala Val Ala Gly Met Ala Leu Gly Asp Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ser Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Arg Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ser Gly Trp Tyr Gly Asn Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  4
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Val Gln Leu Gln Gln Ser Glu Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Val Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Gly Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Val Ser Gly Tyr Gly Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Arg Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Val Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Thr His His Ala Ser Gly Arg Gly Leu Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  6
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Ser Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val Tyr Gly 
            20                  25                  30          


Asp Glu Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Leu Tyr Lys Val Ser Asp Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Asp Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Gly 
            20                  25                  30          


Tyr Ser Pro Gly Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Val Tyr Asn Thr Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Tyr Met Gly Ser 
                85                  90                  95      


Gly Thr Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  8
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Thr 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Phe 
        35                  40                  45              


Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn Tyr 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105             


<210>  9
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Leu Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Asn Arg 
                85                  90                  95      


Glu Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110     


<210>  10
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Ala Met Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ile Asn Val Val Ala 
            20                  25                  30          


Tyr Asn Ile Tyr Trp Tyr Arg Gln Lys Ser Gly Ser Pro Pro Gln Ser 
        35                  40                  45              


Val Leu Arg Tyr Lys Ser Asp Ser Asp Ser Glu Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Lys Asp Val Ser Ala Asn Ala Gly Ile 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Leu Ile Trp His Asn Ser Ala Trp Val Phe Gly Gly Gly Thr Gln Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR1

<400>  11

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR2

<400>  12

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR3

<400>  13

Ala Arg His Glu Trp Gly Phe Gly Met Asp Val 
1               5                   10      


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR1

<400>  14

Gly Tyr Arg Phe Thr Asp Asn Trp 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR2

<400>  15

Ile Tyr Pro Gly Asp Ser Glu Thr 
1               5               


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR3

<400>  16

Ala Arg His Ala Pro Leu Ala Val Ala Gly Met Ala Leu Gly Asp 
1               5                   10                  15  


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR1

<400>  17

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR2

<400>  18

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  19
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR3

<400>  19

Ala Arg Leu Gly Ser Gly Trp Tyr Gly Asn Asp Tyr 
1               5                   10          


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR1

<400>  20

Gly Tyr Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR2

<400>  21

Ile Tyr Pro Gly Asp Gly Asp Thr 
1               5               


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR3

<400>  22

Ala Arg Gly Val Ser Gly Tyr Gly Ala Met Asp Tyr 
1               5                   10          


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR1

<400>  23

Gly Tyr Arg Phe Thr Ser Tyr Trp 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR2

<400>  24

Ile Tyr Pro Gly Asp Ser Asp Thr 
1               5               


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H-CDR3

<400>  25

Ala Thr His His Ala Ser Gly Arg Gly Leu Asp Pro 
1               5                   10          


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR1

<400>  26

Leu Ser Leu Val Tyr Gly Asp Glu Asn Thr Tyr 
1               5                   10      


<210>  27
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR2

<400>  27

Lys Val Ser 
1           


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR3

<400>  28

Met Gln Gly Thr His Trp Pro 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR1

<400>  29

Ser Gly Ser Val Ser Thr Gly Tyr Ser 
1               5                   


<210>  30
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR2

<400>  30

Asn Thr Asn 
1           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR3

<400>  31

Ala Leu Tyr Met Gly Ser Gly Thr Tyr 
1               5                   


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR1

<400>  32

Ser Leu Arg Ser Tyr Tyr 
1               5       


<210>  33
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR2

<400>  33

Gly Lys Asn 
1           


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR3

<400>  34

Asn Ser Arg Asp Ser Ser Gly Asn Tyr Ala 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR1

<400>  35

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  36
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR2

<400>  36

Leu Ala Ser 
1           


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR3

<400>  37

Gln His Asn Arg Glu Leu 
1               5       


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR1

<400>  38

Ser Gly Ile Asn Val Val Ala Tyr Asn 
1               5                   


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR2

<400>  39

Tyr Lys Ser Asp Ser Asp Ser 
1               5           


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L-CDR3

<400>  40

Leu Ile Trp His Asn Ser Ala Trp 
1               5               


