                         SEQUENCE LISTING

<110>  Mount Sinai Hospital
 
<120>  HOMOLOGOUS RECOMBINATION FACTORS

<130>  3153-P50509PC00

<150>  US 62/127,013
<151>  2015-03-02

<150>  US 62/222,542
<151>  2015-09-23

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1

Lys Glu Lys Leu Lys Glu Lys Leu Ala Phe Leu Lys Arg Glu Tyr Ser 
1               5                   10                  15      


Lys Thr Leu Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Lys Ile Lys 
            20                  25                  30          


<210>  2
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Glu Arg Leu Arg Glu Arg Leu Ala Phe Leu Arg Arg Glu Tyr Ser 
1               5                   10                  15      


Arg Thr Leu Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Arg Ile Arg 
            20                  25                  30          


<210>  3
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Glu Arg Leu Arg Glu Lys Leu Ala Phe Leu Lys Arg Glu Tyr Ser 
1               5                   10                  15      


Lys Thr Leu Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Arg Ile Arg 
            20                  25                  30          


<210>  4
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Arg Gly Gly 
1               


<210>  5
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Val Ala Pro Arg Leu Phe Gly Gly Leu Cys Phe Arg Phe Arg 
1               5                   10                  15      


Asp Gln Asn Pro Glu Val Ala Val Glu Gly Arg Leu Pro Ile Ser His 
            20                  25                  30          


Ser Cys Val Gly Cys Arg Arg Glu Arg Thr Ala Met Ala Thr Val Ala 
        35                  40                  45              


Ala Asn Pro Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Val 
    50                  55                  60                  


Thr Glu Asp Arg Glu Pro Gln His Glu Glu Leu Pro Gly Leu Asp Ser 
65                  70                  75                  80  


Gln Trp Arg Gln Ile Glu Asn Gly Glu Ser Gly Arg Glu Arg Pro Leu 
                85                  90                  95      


Arg Ala Gly Glu Ser Trp Phe Leu Val Glu Lys His Trp Tyr Lys Gln 
            100                 105                 110         


Trp Glu Ala Tyr Val Gln Gly Gly Asp Gln Asp Ser Ser Thr Phe Pro 
        115                 120                 125             


Gly Cys Ile Asn Asn Ala Thr Leu Phe Gln Asp Glu Ile Asn Trp Arg 
    130                 135                 140                 


Leu Lys Glu Gly Leu Val Glu Gly Glu Asp Tyr Val Leu Leu Pro Ala 
145                 150                 155                 160 


Ala Ala Trp His Tyr Leu Val Ser Trp Tyr Gly Leu Glu His Gly Gln 
                165                 170                 175     


Pro Pro Ile Glu Arg Lys Val Ile Glu Leu Pro Asn Ile Gln Lys Val 
            180                 185                 190         


Glu Val Tyr Pro Val Glu Leu Leu Leu Val Arg His Asn Asp Leu Gly 
        195                 200                 205             


Lys Ser His Thr Val Gln Phe Ser His Thr Asp Ser Ile Gly Leu Val 
    210                 215                 220                 


Leu Arg Thr Ala Arg Glu Arg Phe Leu Val Glu Pro Gln Glu Asp Thr 
225                 230                 235                 240 


Arg Leu Trp Ala Lys Asn Ser Glu Gly Ser Leu Asp Arg Leu Tyr Asp 
                245                 250                 255     


Thr His Ile Thr Val Leu Asp Ala Ala Leu Glu Thr Gly Gln Leu Ile 
            260                 265                 270         


Ile Met Glu Thr Arg Lys Lys Asp Gly Thr Trp Pro Ser Ala Gln Leu 
        275                 280                 285             


His Val Met Asn Asn Asn Met Ser Glu Glu Asp Glu Asp Phe Lys Gly 
    290                 295                 300                 


Gln Pro Gly Ile Cys Gly Leu Thr Asn Leu Gly Asn Thr Cys Phe Met 
305                 310                 315                 320 


Asn Ser Ala Leu Gln Cys Leu Ser Asn Val Pro Gln Leu Thr Glu Tyr 
                325                 330                 335     


Phe Leu Asn Asn Cys Tyr Leu Glu Glu Leu Asn Phe Arg Asn Pro Leu 
            340                 345                 350         


Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Asp Leu Val Lys Gln 
        355                 360                 365             


Ala Trp Ser Gly His His Arg Ser Ile Val Pro His Val Phe Lys Asn 
    370                 375                 380                 


Lys Val Gly His Phe Ala Ser Gln Phe Leu Gly Tyr Gln Gln His Asp 
385                 390                 395                 400 


Ser Gln Glu Leu Leu Ser Phe Leu Leu Asp Gly Leu His Glu Asp Leu 
                405                 410                 415     


Asn Arg Val Lys Lys Lys Glu Tyr Val Glu Leu Cys Asp Ala Ala Gly 
            420                 425                 430         


Arg Pro Asp Gln Glu Val Ala Gln Glu Ala Trp Gln Asn His Lys Arg 
        435                 440                 445             


Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu Phe Lys Ser 
    450                 455                 460                 


Thr Leu Val Cys Pro Asp Cys Gly Asn Val Ser Val Thr Phe Asp Pro 
465                 470                 475                 480 


Phe Cys Tyr Leu Ser Val Pro Leu Pro Ile Ser His Lys Arg Val Leu 
                485                 490                 495     


Glu Val Phe Phe Ile Pro Met Asp Pro Arg Arg Lys Pro Glu Gln His 
            500                 505                 510         


Arg Leu Val Val Pro Lys Lys Gly Lys Ile Ser Asp Leu Cys Val Ala 
        515                 520                 525             


Leu Ser Lys His Thr Gly Ile Ser Pro Glu Arg Met Met Val Ala Asp 
    530                 535                 540                 


Val Phe Ser His Arg Phe Tyr Lys Leu Tyr Gln Leu Glu Glu Pro Leu 
545                 550                 555                 560 


Ser Ser Ile Leu Asp Arg Asp Asp Ile Phe Val Tyr Glu Val Ser Gly 
                565                 570                 575     


Arg Ile Glu Ala Ile Glu Gly Ser Arg Glu Asp Ile Val Val Pro Val 
            580                 585                 590         


Tyr Leu Arg Glu Arg Thr Pro Ala Arg Asp Tyr Asn Asn Ser Tyr Tyr 
        595                 600                 605             


Gly Leu Met Leu Phe Gly His Pro Leu Leu Val Ser Val Pro Arg Asp 
    610                 615                 620                 


Arg Phe Thr Trp Glu Gly Leu Tyr Asn Val Leu Met Tyr Arg Leu Ser 
625                 630                 635                 640 


Arg Tyr Val Thr Lys Pro Asn Ser Asp Asp Glu Asp Asp Gly Asp Glu 
                645                 650                 655     


Lys Glu Asp Asp Glu Glu Asp Lys Asp Asp Val Pro Gly Pro Ser Thr 
            660                 665                 670         


Gly Gly Ser Leu Arg Asp Pro Glu Pro Glu Gln Ala Gly Pro Ser Ser 
        675                 680                 685             


Gly Val Thr Asn Arg Cys Pro Phe Leu Leu Asp Asn Cys Leu Gly Thr 
    690                 695                 700                 


Ser Gln Trp Pro Pro Arg Arg Arg Arg Lys Gln Leu Phe Thr Leu Gln 
705                 710                 715                 720 


Thr Val Asn Ser Asn Gly Thr Ser Asp Arg Thr Thr Ser Pro Glu Glu 
                725                 730                 735     


Val His Ala Gln Pro Tyr Ile Ala Ile Asp Trp Glu Pro Glu Met Lys 
            740                 745                 750         


Lys Arg Tyr Tyr Asp Glu Val Glu Ala Glu Gly Tyr Val Lys His Asp 
        755                 760                 765             


Cys Val Gly Tyr Val Met Lys Lys Ala Pro Val Arg Leu Gln Glu Cys 
    770                 775                 780                 


Ile Glu Leu Phe Thr Thr Val Glu Thr Leu Glu Lys Glu Asn Pro Trp 
785                 790                 795                 800 


Tyr Cys Pro Ser Cys Lys Gln His Gln Leu Ala Thr Lys Lys Leu Asp 
                805                 810                 815     


Leu Trp Met Leu Pro Glu Ile Leu Ile Ile His Leu Lys Arg Phe Ser 
            820                 825                 830         


Tyr Thr Lys Phe Ser Arg Glu Lys Leu Asp Thr Leu Val Glu Phe Pro 
        835                 840                 845             


Ile Arg Asp Leu Asp Phe Ser Glu Phe Val Ile Gln Pro Gln Asn Glu 
    850                 855                 860                 


Ser Asn Pro Glu Leu Tyr Lys Tyr Asp Leu Ile Ala Val Ser Asn His 
865                 870                 875                 880 


Tyr Gly Gly Met Arg Asp Gly His Tyr Thr Thr Phe Ala Cys Asn Lys 
                885                 890                 895     


Asp Ser Gly Gln Trp His Tyr Phe Asp Asp Asn Ser Val Ser Pro Val 
            900                 905                 910         


Asn Glu Asn Gln Ile Glu Ser Lys Ala Ala Tyr Val Leu Phe Tyr Gln 
        915                 920                 925             


Arg Gln Asp Val Ala Arg Arg Leu Leu Ser Pro Ala Gly Ser Ser Gly 
    930                 935                 940                 


Ala Pro Ala Ser Pro Ala Cys Ser Ser Pro Pro Ser Ser Glu Phe Met 
945                 950                 955                 960 


Asp Val Asn 
            


<210>  6
<211>  1186
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Glu Pro Pro Gly Lys Pro Leu Ser Cys Glu Glu Lys Glu Lys 
1               5                   10                  15      


Leu Lys Glu Lys Leu Ala Phe Leu Lys Arg Glu Tyr Ser Lys Thr Leu 
            20                  25                  30          


Ala Arg Leu Gln Arg Ala Gln Arg Ala Glu Lys Ile Lys His Ser Ile 
        35                  40                  45              


Lys Lys Thr Val Glu Glu Gln Asp Cys Leu Ser Gln Gln Asp Leu Ser 
    50                  55                  60                  


Pro Gln Leu Lys His Ser Glu Pro Lys Asn Lys Ile Cys Val Tyr Asp 
65                  70                  75                  80  


Lys Leu His Ile Lys Thr His Leu Asp Glu Glu Thr Gly Glu Lys Thr 
                85                  90                  95      


Ser Ile Thr Leu Asp Val Gly Pro Glu Ser Phe Asn Pro Gly Asp Gly 
            100                 105                 110         


Pro Gly Gly Leu Pro Ile Gln Arg Thr Asp Asp Thr Gln Glu His Phe 
        115                 120                 125             


Pro His Arg Val Ser Asp Pro Ser Gly Glu Gln Lys Gln Lys Leu Pro 
    130                 135                 140                 


Ser Arg Arg Lys Lys Gln Gln Lys Arg Thr Phe Ile Ser Gln Glu Arg 
145                 150                 155                 160 


Asp Cys Val Phe Gly Thr Asp Ser Leu Arg Leu Ser Gly Lys Arg Leu 
                165                 170                 175     


Lys Glu Gln Glu Glu Ile Ser Ser Lys Asn Pro Ala Arg Ser Pro Val 
            180                 185                 190         


Thr Glu Ile Arg Thr His Leu Leu Ser Leu Lys Ser Glu Leu Pro Asp 
        195                 200                 205             


Ser Pro Glu Pro Val Thr Glu Ile Asn Glu Asp Ser Val Leu Ile Pro 
    210                 215                 220                 


Pro Thr Ala Gln Pro Glu Lys Gly Val Asp Thr Phe Leu Arg Arg Pro 
225                 230                 235                 240 


Asn Phe Thr Arg Ala Thr Thr Val Pro Leu Gln Thr Leu Ser Asp Ser 
                245                 250                 255     


Gly Ser Ser Gln His Leu Glu His Ile Pro Pro Lys Gly Ser Ser Glu 
            260                 265                 270         


Leu Thr Thr His Asp Leu Lys Asn Ile Arg Phe Thr Ser Pro Val Ser 
        275                 280                 285             


Leu Glu Ala Gln Gly Lys Lys Met Thr Val Ser Thr Asp Asn Leu Leu 
    290                 295                 300                 


Val Asn Lys Ala Ile Ser Lys Ser Gly Gln Leu Pro Thr Ser Ser Asn 
305                 310                 315                 320 


Leu Glu Ala Asn Ile Ser Cys Ser Leu Asn Glu Leu Thr Tyr Asn Asn 
                325                 330                 335     


Leu Pro Ala Asn Glu Asn Gln Asn Leu Lys Glu Gln Asn Gln Thr Glu 
            340                 345                 350         


Lys Ser Leu Lys Ser Pro Ser Asp Thr Leu Asp Gly Arg Asn Glu Asn 
        355                 360                 365             


Leu Gln Glu Ser Glu Ile Leu Ser Gln Pro Lys Ser Leu Ser Leu Glu 
    370                 375                 380                 


Ala Thr Ser Pro Leu Ser Ala Glu Lys His Ser Cys Thr Val Pro Glu 
385                 390                 395                 400 


Gly Leu Leu Phe Pro Ala Glu Tyr Tyr Val Arg Thr Thr Arg Ser Met 
                405                 410                 415     


Ser Asn Cys Gln Arg Lys Val Ala Val Glu Ala Val Ile Gln Ser His 
            420                 425                 430         


Leu Asp Val Lys Lys Lys Gly Phe Lys Asn Lys Asn Lys Asp Ala Ser 
        435                 440                 445             


Lys Asn Leu Asn Leu Ser Asn Glu Glu Thr Asp Gln Ser Glu Ile Arg 
    450                 455                 460                 


Met Ser Gly Thr Cys Thr Gly Gln Pro Ser Ser Arg Thr Ser Gln Lys 
465                 470                 475                 480 


Leu Leu Ser Leu Thr Lys Val Ser Ser Pro Ala Gly Pro Thr Glu Asp 
                485                 490                 495     


Asn Asp Leu Ser Arg Lys Ala Val Ala Gln Ala Pro Gly Arg Arg Tyr 
            500                 505                 510         


Thr Gly Lys Arg Lys Ser Ala Cys Thr Pro Ala Ser Asp His Cys Glu 
        515                 520                 525             


Pro Leu Leu Pro Thr Ser Ser Leu Ser Ile Val Asn Arg Ser Lys Glu 
    530                 535                 540                 


Glu Val Thr Ser His Lys Tyr Gln His Glu Lys Leu Phe Ile Gln Val 
545                 550                 555                 560 


Lys Gly Lys Lys Ser Arg His Gln Lys Glu Asp Ser Leu Ser Trp Ser 
                565                 570                 575     


Asn Ser Ala Tyr Leu Ser Leu Asp Asp Asp Ala Phe Thr Ala Pro Phe 
            580                 585                 590         


His Arg Asp Gly Met Leu Ser Leu Lys Gln Leu Leu Ser Phe Leu Ser 
        595                 600                 605             


Ile Thr Asp Phe Gln Leu Pro Asp Glu Asp Phe Gly Pro Leu Lys Leu 
    610                 615                 620                 


Glu Lys Val Lys Ser Cys Ser Glu Lys Pro Val Glu Pro Phe Glu Ser 
625                 630                 635                 640 


Lys Met Phe Gly Glu Arg His Leu Lys Glu Gly Ser Cys Ile Phe Pro 
                645                 650                 655     


Glu Glu Leu Ser Pro Lys Arg Met Asp Thr Glu Met Glu Asp Leu Glu 
            660                 665                 670         


Glu Asp Leu Ile Val Leu Pro Gly Lys Ser His Pro Lys Arg Pro Asn 
        675                 680                 685             


Ser Gln Ser Gln His Thr Lys Thr Gly Leu Ser Ser Ser Ile Leu Leu 
    690                 695                 700                 


Tyr Thr Pro Leu Asn Thr Val Ala Pro Asp Asp Asn Asp Arg Pro Thr 
705                 710                 715                 720 


Thr Asp Met Cys Ser Pro Ala Phe Pro Ile Leu Gly Thr Thr Pro Ala 
                725                 730                 735     


Phe Gly Pro Gln Gly Ser Tyr Glu Lys Ala Ser Thr Glu Val Ala Gly 
            740                 745                 750         


Arg Thr Cys Cys Thr Pro Gln Leu Ala His Leu Lys Asp Ser Val Cys 
        755                 760                 765             


Leu Ala Ser Asp Thr Lys Gln Phe Asp Ser Ser Gly Ser Pro Ala Lys 
    770                 775                 780                 


Pro His Thr Thr Leu Gln Val Ser Gly Arg Gln Gly Gln Pro Thr Cys 
785                 790                 795                 800 


Asp Cys Asp Ser Val Pro Pro Gly Thr Pro Pro Pro Ile Glu Ser Phe 
                805                 810                 815     


Thr Phe Lys Glu Asn Gln Leu Cys Arg Asn Thr Cys Gln Glu Leu His 
            820                 825                 830         


Lys His Ser Val Glu Gln Thr Glu Thr Ala Glu Leu Pro Ala Ser Asp 
        835                 840                 845             


Ser Ile Asn Pro Gly Asn Leu Gln Leu Val Ser Glu Leu Lys Asn Pro 
    850                 855                 860                 


Ser Gly Ser Cys Ser Val Asp Val Ser Ala Met Phe Trp Glu Arg Ala 
865                 870                 875                 880 


Gly Cys Lys Glu Pro Cys Ile Ile Thr Ala Cys Glu Asp Val Val Ser 
                885                 890                 895     


Leu Trp Lys Ala Leu Asp Ala Trp Gln Trp Glu Lys Leu Tyr Thr Trp 
            900                 905                 910         


His Phe Ala Glu Val Pro Val Leu Gln Ile Val Pro Val Pro Asp Val 
        915                 920                 925             


Tyr Asn Leu Val Cys Val Ala Leu Gly Asn Leu Glu Ile Arg Glu Ile 
    930                 935                 940                 


Arg Ala Leu Phe Cys Ser Ser Asp Asp Glu Ser Glu Lys Gln Val Leu 
945                 950                 955                 960 


Leu Lys Ser Gly Asn Ile Lys Ala Val Leu Gly Leu Thr Lys Arg Arg 
                965                 970                 975     


Leu Val Ser Ser Ser Gly Thr Leu Ser Asp Gln Gln Val Glu Val Met 
            980                 985                 990         


Thr Phe Ala Glu Asp Gly Gly Gly  Lys Glu Asn Gln Phe  Leu Met Pro 
        995                 1000                 1005             


Pro Glu  Glu Thr Ile Leu Thr  Phe Ala Glu Val Gln  Gly Met Gln 
    1010                 1015                 1020             


Glu Ala  Leu Leu Gly Thr Thr  Ile Met Asn Asn Ile  Val Ile Trp 
    1025                 1030                 1035             


Asn Leu  Lys Thr Gly Gln Leu  Leu Lys Lys Met His  Ile Asp Asp 
    1040                 1045                 1050             


Ser Tyr  Gln Ala Ser Val Cys  His Lys Ala Tyr Ser  Glu Met Gly 
    1055                 1060                 1065             


Leu Leu  Phe Ile Val Leu Ser  His Pro Cys Ala Lys  Glu Ser Glu 
    1070                 1075                 1080             


Ser Leu  Arg Ser Pro Val Phe  Gln Leu Ile Val Ile  Asn Pro Lys 
    1085                 1090                 1095             


Thr Thr  Leu Ser Val Gly Val  Met Leu Tyr Cys Leu  Pro Pro Gly 
    1100                 1105                 1110             


Gln Ala  Gly Arg Phe Leu Glu  Gly Asp Val Lys Asp  His Cys Ala 
    1115                 1120                 1125             


Ala Ala  Ile Leu Thr Ser Gly  Thr Ile Ala Ile Trp  Asp Leu Leu 
    1130                 1135                 1140             


Leu Gly  Gln Cys Thr Ala Leu  Leu Pro Pro Val Ser  Asp Gln His 
    1145                 1150                 1155             


Trp Ser  Phe Val Lys Trp Ser  Gly Thr Asp Ser His  Leu Leu Ala 
    1160                 1165                 1170             


Gly Gln  Lys Asp Gly Asn Ile  Phe Val Tyr His Tyr  Ser 
    1175                 1180                 1185     


<210>  7
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  8
<211>  3418
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Ile Gly Ser Lys Glu Arg Pro Thr Phe Phe Glu Ile Phe Lys 
1               5                   10                  15      


Thr Arg Cys Asn Lys Ala Asp Leu Gly Pro Ile Ser Leu Asn Trp Phe 
            20                  25                  30          


Glu Glu Leu Ser Ser Glu Ala Pro Pro Tyr Asn Ser Glu Pro Ala Glu 
        35                  40                  45              


Glu Ser Glu His Lys Asn Asn Asn Tyr Glu Pro Asn Leu Phe Lys Thr 
    50                  55                  60                  


Pro Gln Arg Lys Pro Ser Tyr Asn Gln Leu Ala Ser Thr Pro Ile Ile 
65                  70                  75                  80  


Phe Lys Glu Gln Gly Leu Thr Leu Pro Leu Tyr Gln Ser Pro Val Lys 
                85                  90                  95      


Glu Leu Asp Lys Phe Lys Leu Asp Leu Gly Arg Asn Val Pro Asn Ser 
            100                 105                 110         


Arg His Lys Ser Leu Arg Thr Val Lys Thr Lys Met Asp Gln Ala Asp 
        115                 120                 125             


Asp Val Ser Cys Pro Leu Leu Asn Ser Cys Leu Ser Glu Ser Pro Val 
    130                 135                 140                 


Val Leu Gln Cys Thr His Val Thr Pro Gln Arg Asp Lys Ser Val Val 
145                 150                 155                 160 


Cys Gly Ser Leu Phe His Thr Pro Lys Phe Val Lys Gly Arg Gln Thr 
                165                 170                 175     


Pro Lys His Ile Ser Glu Ser Leu Gly Ala Glu Val Asp Pro Asp Met 
            180                 185                 190         


Ser Trp Ser Ser Ser Leu Ala Thr Pro Pro Thr Leu Ser Ser Thr Val 
        195                 200                 205             


Leu Ile Val Arg Asn Glu Glu Ala Ser Glu Thr Val Phe Pro His Asp 
    210                 215                 220                 


Thr Thr Ala Asn Val Lys Ser Tyr Phe Ser Asn His Asp Glu Ser Leu 
225                 230                 235                 240 


Lys Lys Asn Asp Arg Phe Ile Ala Ser Val Thr Asp Ser Glu Asn Thr 
                245                 250                 255     


Asn Gln Arg Glu Ala Ala Ser His Gly Phe Gly Lys Thr Ser Gly Asn 
            260                 265                 270         


Ser Phe Lys Val Asn Ser Cys Lys Asp His Ile Gly Lys Ser Met Pro 
        275                 280                 285             


Asn Val Leu Glu Asp Glu Val Tyr Glu Thr Val Val Asp Thr Ser Glu 
    290                 295                 300                 


Glu Asp Ser Phe Ser Leu Cys Phe Ser Lys Cys Arg Thr Lys Asn Leu 
305                 310                 315                 320 


Gln Lys Val Arg Thr Ser Lys Thr Arg Lys Lys Ile Phe His Glu Ala 
                325                 330                 335     


Asn Ala Asp Glu Cys Glu Lys Ser Lys Asn Gln Val Lys Glu Lys Tyr 
            340                 345                 350         


Ser Phe Val Ser Glu Val Glu Pro Asn Asp Thr Asp Pro Leu Asp Ser 
        355                 360                 365             


Asn Val Ala Asn Gln Lys Pro Phe Glu Ser Gly Ser Asp Lys Ile Ser 
    370                 375                 380                 


Lys Glu Val Val Pro Ser Leu Ala Cys Glu Trp Ser Gln Leu Thr Leu 
385                 390                 395                 400 


Ser Gly Leu Asn Gly Ala Gln Met Glu Lys Ile Pro Leu Leu His Ile 
                405                 410                 415     


Ser Ser Cys Asp Gln Asn Ile Ser Glu Lys Asp Leu Leu Asp Thr Glu 
            420                 425                 430         


Asn Lys Arg Lys Lys Asp Phe Leu Thr Ser Glu Asn Ser Leu Pro Arg 
        435                 440                 445             


Ile Ser Ser Leu Pro Lys Ser Glu Lys Pro Leu Asn Glu Glu Thr Val 
    450                 455                 460                 


Val Asn Lys Arg Asp Glu Glu Gln His Leu Glu Ser His Thr Asp Cys 
465                 470                 475                 480 


Ile Leu Ala Val Lys Gln Ala Ile Ser Gly Thr Ser Pro Val Ala Ser 
                485                 490                 495     


Ser Phe Gln Gly Ile Lys Lys Ser Ile Phe Arg Ile Arg Glu Ser Pro 
            500                 505                 510         


Lys Glu Thr Phe Asn Ala Ser Phe Ser Gly His Met Thr Asp Pro Asn 
        515                 520                 525             


Phe Lys Lys Glu Thr Glu Ala Ser Glu Ser Gly Leu Glu Ile His Thr 
    530                 535                 540                 


Val Cys Ser Gln Lys Glu Asp Ser Leu Cys Pro Asn Leu Ile Asp Asn 
545                 550                 555                 560 


Gly Ser Trp Pro Ala Thr Thr Thr Gln Asn Ser Val Ala Leu Lys Asn 
                565                 570                 575     


Ala Gly Leu Ile Ser Thr Leu Lys Lys Lys Thr Asn Lys Phe Ile Tyr 
            580                 585                 590         


Ala Ile His Asp Glu Thr Ser Tyr Lys Gly Lys Lys Ile Pro Lys Asp 
        595                 600                 605             


Gln Lys Ser Glu Leu Ile Asn Cys Ser Ala Gln Phe Glu Ala Asn Ala 
    610                 615                 620                 


Phe Glu Ala Pro Leu Thr Phe Ala Asn Ala Asp Ser Gly Leu Leu His 
625                 630                 635                 640 


Ser Ser Val Lys Arg Ser Cys Ser Gln Asn Asp Ser Glu Glu Pro Thr 
                645                 650                 655     


Leu Ser Leu Thr Ser Ser Phe Gly Thr Ile Leu Arg Lys Cys Ser Arg 
            660                 665                 670         


Asn Glu Thr Cys Ser Asn Asn Thr Val Ile Ser Gln Asp Leu Asp Tyr 
        675                 680                 685             


Lys Glu Ala Lys Cys Asn Lys Glu Lys Leu Gln Leu Phe Ile Thr Pro 
    690                 695                 700                 


Glu Ala Asp Ser Leu Ser Cys Leu Gln Glu Gly Gln Cys Glu Asn Asp 
705                 710                 715                 720 


Pro Lys Ser Lys Lys Val Ser Asp Ile Lys Glu Glu Val Leu Ala Ala 
                725                 730                 735     


Ala Cys His Pro Val Gln His Ser Lys Val Glu Tyr Ser Asp Thr Asp 
            740                 745                 750         


Phe Gln Ser Gln Lys Ser Leu Leu Tyr Asp His Glu Asn Ala Ser Thr 
        755                 760                 765             


Leu Ile Leu Thr Pro Thr Ser Lys Asp Val Leu Ser Asn Leu Val Met 
    770                 775                 780                 


Ile Ser Arg Gly Lys Glu Ser Tyr Lys Met Ser Asp Lys Leu Lys Gly 
785                 790                 795                 800 


Asn Asn Tyr Glu Ser Asp Val Glu Leu Thr Lys Asn Ile Pro Met Glu 
                805                 810                 815     


Lys Asn Gln Asp Val Cys Ala Leu Asn Glu Asn Tyr Lys Asn Val Glu 
            820                 825                 830         


Leu Leu Pro Pro Glu Lys Tyr Met Arg Val Ala Ser Pro Ser Arg Lys 
        835                 840                 845             


Val Gln Phe Asn Gln Asn Thr Asn Leu Arg Val Ile Gln Lys Asn Gln 
    850                 855                 860                 


Glu Glu Thr Thr Ser Ile Ser Lys Ile Thr Val Asn Pro Asp Ser Glu 
865                 870                 875                 880 


Glu Leu Phe Ser Asp Asn Glu Asn Asn Phe Val Phe Gln Val Ala Asn 
                885                 890                 895     


Glu Arg Asn Asn Leu Ala Leu Gly Asn Thr Lys Glu Leu His Glu Thr 
            900                 905                 910         


Asp Leu Thr Cys Val Asn Glu Pro Ile Phe Lys Asn Ser Thr Met Val 
        915                 920                 925             


Leu Tyr Gly Asp Thr Gly Asp Lys Gln Ala Thr Gln Val Ser Ile Lys 
    930                 935                 940                 


Lys Asp Leu Val Tyr Val Leu Ala Glu Glu Asn Lys Asn Ser Val Lys 
945                 950                 955                 960 


Gln His Ile Lys Met Thr Leu Gly Gln Asp Leu Lys Ser Asp Ile Ser 
                965                 970                 975     


Leu Asn Ile Asp Lys Ile Pro Glu Lys Asn Asn Asp Tyr Met Asn Lys 
            980                 985                 990         


Trp Ala Gly Leu Leu Gly Pro Ile  Ser Asn His Ser Phe  Gly Gly Ser 
        995                 1000                 1005             


Phe Arg  Thr Ala Ser Asn Lys  Glu Ile Lys Leu Ser  Glu His Asn 
    1010                 1015                 1020             


Ile Lys  Lys Ser Lys Met Phe  Phe Lys Asp Ile Glu  Glu Gln Tyr 
    1025                 1030                 1035             


Pro Thr  Ser Leu Ala Cys Val  Glu Ile Val Asn Thr  Leu Ala Leu 
    1040                 1045                 1050             


Asp Asn  Gln Lys Lys Leu Ser  Lys Pro Gln Ser Ile  Asn Thr Val 
    1055                 1060                 1065             


Ser Ala  His Leu Gln Ser Ser  Val Val Val Ser Asp  Cys Lys Asn 
    1070                 1075                 1080             


Ser His  Ile Thr Pro Gln Met  Leu Phe Ser Lys Gln  Asp Phe Asn 
    1085                 1090                 1095             


Ser Asn  His Asn Leu Thr Pro  Ser Gln Lys Ala Glu  Ile Thr Glu 
    1100                 1105                 1110             


Leu Ser  Thr Ile Leu Glu Glu  Ser Gly Ser Gln Phe  Glu Phe Thr 
    1115                 1120                 1125             


Gln Phe  Arg Lys Pro Ser Tyr  Ile Leu Gln Lys Ser  Thr Phe Glu 
    1130                 1135                 1140             


Val Pro  Glu Asn Gln Met Thr  Ile Leu Lys Thr Thr  Ser Glu Glu 
    1145                 1150                 1155             


Cys Arg  Asp Ala Asp Leu His  Val Ile Met Asn Ala  Pro Ser Ile 
    1160                 1165                 1170             


Gly Gln  Val Asp Ser Ser Lys  Gln Phe Glu Gly Thr  Val Glu Ile 
    1175                 1180                 1185             


Lys Arg  Lys Phe Ala Gly Leu  Leu Lys Asn Asp Cys  Asn Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Tyr Leu Thr Asp  Glu Asn Glu Val Gly  Phe Arg Gly 
    1205                 1210                 1215             


Phe Tyr  Ser Ala His Gly Thr  Lys Leu Asn Val Ser  Thr Glu Ala 
    1220                 1225                 1230             


Leu Gln  Lys Ala Val Lys Leu  Phe Ser Asp Ile Glu  Asn Ile Ser 
    1235                 1240                 1245             


Glu Glu  Thr Ser Ala Glu Val  His Pro Ile Ser Leu  Ser Ser Ser 
    1250                 1255                 1260             


Lys Cys  His Asp Ser Val Val  Ser Met Phe Lys Ile  Glu Asn His 
    1265                 1270                 1275             


Asn Asp  Lys Thr Val Ser Glu  Lys Asn Asn Lys Cys  Gln Leu Ile 
    1280                 1285                 1290             


Leu Gln  Asn Asn Ile Glu Met  Thr Thr Gly Thr Phe  Val Glu Glu 
    1295                 1300                 1305             


Ile Thr  Glu Asn Tyr Lys Arg  Asn Thr Glu Asn Glu  Asp Asn Lys 
    1310                 1315                 1320             


Tyr Thr  Ala Ala Ser Arg Asn  Ser His Asn Leu Glu  Phe Asp Gly 
    1325                 1330                 1335             


Ser Asp  Ser Ser Lys Asn Asp  Thr Val Cys Ile His  Lys Asp Glu 
    1340                 1345                 1350             


Thr Asp  Leu Leu Phe Thr Asp  Gln His Asn Ile Cys  Leu Lys Leu 
    1355                 1360                 1365             


Ser Gly  Gln Phe Met Lys Glu  Gly Asn Thr Gln Ile  Lys Glu Asp 
    1370                 1375                 1380             


Leu Ser  Asp Leu Thr Phe Leu  Glu Val Ala Lys Ala  Gln Glu Ala 
    1385                 1390                 1395             


Cys His  Gly Asn Thr Ser Asn  Lys Glu Gln Leu Thr  Ala Thr Lys 
    1400                 1405                 1410             


Thr Glu  Gln Asn Ile Lys Asp  Phe Glu Thr Ser Asp  Thr Phe Phe 
    1415                 1420                 1425             


Gln Thr  Ala Ser Gly Lys Asn  Ile Ser Val Ala Lys  Glu Ser Phe 
    1430                 1435                 1440             


Asn Lys  Ile Val Asn Phe Phe  Asp Gln Lys Pro Glu  Glu Leu His 
    1445                 1450                 1455             


Asn Phe  Ser Leu Asn Ser Glu  Leu His Ser Asp Ile  Arg Lys Asn 
    1460                 1465                 1470             


Lys Met  Asp Ile Leu Ser Tyr  Glu Glu Thr Asp Ile  Val Lys His 
    1475                 1480                 1485             


Lys Ile  Leu Lys Glu Ser Val  Pro Val Gly Thr Gly  Asn Gln Leu 
    1490                 1495                 1500             


Val Thr  Phe Gln Gly Gln Pro  Glu Arg Asp Glu Lys  Ile Lys Glu 
    1505                 1510                 1515             


Pro Thr  Leu Leu Gly Phe His  Thr Ala Ser Gly Lys  Lys Val Lys 
    1520                 1525                 1530             


Ile Ala  Lys Glu Ser Leu Asp  Lys Val Lys Asn Leu  Phe Asp Glu 
    1535                 1540                 1545             


Lys Glu  Gln Gly Thr Ser Glu  Ile Thr Ser Phe Ser  His Gln Trp 
    1550                 1555                 1560             


Ala Lys  Thr Leu Lys Tyr Arg  Glu Ala Cys Lys Asp  Leu Glu Leu 
    1565                 1570                 1575             


Ala Cys  Glu Thr Ile Glu Ile  Thr Ala Ala Pro Lys  Cys Lys Glu 
    1580                 1585                 1590             


Met Gln  Asn Ser Leu Asn Asn  Asp Lys Asn Leu Val  Ser Ile Glu 
    1595                 1600                 1605             


Thr Val  Val Pro Pro Lys Leu  Leu Ser Asp Asn Leu  Cys Arg Gln 
    1610                 1615                 1620             


Thr Glu  Asn Leu Lys Thr Ser  Lys Ser Ile Phe Leu  Lys Val Lys 
    1625                 1630                 1635             


Val His  Glu Asn Val Glu Lys  Glu Thr Ala Lys Ser  Pro Ala Thr 
    1640                 1645                 1650             


Cys Tyr  Thr Asn Gln Ser Pro  Tyr Ser Val Ile Glu  Asn Ser Ala 
    1655                 1660                 1665             


Leu Ala  Phe Tyr Thr Ser Cys  Ser Arg Lys Thr Ser  Val Ser Gln 
    1670                 1675                 1680             


Thr Ser  Leu Leu Glu Ala Lys  Lys Trp Leu Arg Glu  Gly Ile Phe 
    1685                 1690                 1695             


Asp Gly  Gln Pro Glu Arg Ile  Asn Thr Ala Asp Tyr  Val Gly Asn 
    1700                 1705                 1710             


Tyr Leu  Tyr Glu Asn Asn Ser  Asn Ser Thr Ile Ala  Glu Asn Asp 
    1715                 1720                 1725             


Lys Asn  His Leu Ser Glu Lys  Gln Asp Thr Tyr Leu  Ser Asn Ser 
    1730                 1735                 1740             


Ser Met  Ser Asn Ser Tyr Ser  Tyr His Ser Asp Glu  Val Tyr Asn 
    1745                 1750                 1755             


Asp Ser  Gly Tyr Leu Ser Lys  Asn Lys Leu Asp Ser  Gly Ile Glu 
    1760                 1765                 1770             


Pro Val  Leu Lys Asn Val Glu  Asp Gln Lys Asn Thr  Ser Phe Ser 
    1775                 1780                 1785             


Lys Val  Ile Ser Asn Val Lys  Asp Ala Asn Ala Tyr  Pro Gln Thr 
    1790                 1795                 1800             


Val Asn  Glu Asp Ile Cys Val  Glu Glu Leu Val Thr  Ser Ser Ser 
    1805                 1810                 1815             


Pro Cys  Lys Asn Lys Asn Ala  Ala Ile Lys Leu Ser  Ile Ser Asn 
    1820                 1825                 1830             


Ser Asn  Asn Phe Glu Val Gly  Pro Pro Ala Phe Arg  Ile Ala Ser 
    1835                 1840                 1845             


Gly Lys  Ile Val Cys Val Ser  His Glu Thr Ile Lys  Lys Val Lys 
    1850                 1855                 1860             


Asp Ile  Phe Thr Asp Ser Phe  Ser Lys Val Ile Lys  Glu Asn Asn 
    1865                 1870                 1875             


Glu Asn  Lys Ser Lys Ile Cys  Gln Thr Lys Ile Met  Ala Gly Cys 
    1880                 1885                 1890             


Tyr Glu  Ala Leu Asp Asp Ser  Glu Asp Ile Leu His  Asn Ser Leu 
    1895                 1900                 1905             


Asp Asn  Asp Glu Cys Ser Thr  His Ser His Lys Val  Phe Ala Asp 
    1910                 1915                 1920             


Ile Gln  Ser Glu Glu Ile Leu  Gln His Asn Gln Asn  Met Ser Gly 
    1925                 1930                 1935             


Leu Glu  Lys Val Ser Lys Ile  Ser Pro Cys Asp Val  Ser Leu Glu 
    1940                 1945                 1950             


Thr Ser  Asp Ile Cys Lys Cys  Ser Ile Gly Lys Leu  His Lys Ser 
    1955                 1960                 1965             


Val Ser  Ser Ala Asn Thr Cys  Gly Ile Phe Ser Thr  Ala Ser Gly 
    1970                 1975                 1980             


Lys Ser  Val Gln Val Ser Asp  Ala Ser Leu Gln Asn  Ala Arg Gln 
    1985                 1990                 1995             


Val Phe  Ser Glu Ile Glu Asp  Ser Thr Lys Gln Val  Phe Ser Lys 
    2000                 2005                 2010             


Val Leu  Phe Lys Ser Asn Glu  His Ser Asp Gln Leu  Thr Arg Glu 
    2015                 2020                 2025             


Glu Asn  Thr Ala Ile Arg Thr  Pro Glu His Leu Ile  Ser Gln Lys 
    2030                 2035                 2040             


Gly Phe  Ser Tyr Asn Val Val  Asn Ser Ser Ala Phe  Ser Gly Phe 
    2045                 2050                 2055             


Ser Thr  Ala Ser Gly Lys Gln  Val Ser Ile Leu Glu  Ser Ser Leu 
    2060                 2065                 2070             


His Lys  Val Lys Gly Val Leu  Glu Glu Phe Asp Leu  Ile Arg Thr 
    2075                 2080                 2085             


Glu His  Ser Leu His Tyr Ser  Pro Thr Ser Arg Gln  Asn Val Ser 
    2090                 2095                 2100             


Lys Ile  Leu Pro Arg Val Asp  Lys Arg Asn Pro Glu  His Cys Val 
    2105                 2110                 2115             


Asn Ser  Glu Met Glu Lys Thr  Cys Ser Lys Glu Phe  Lys Leu Ser 
    2120                 2125                 2130             


Asn Asn  Leu Asn Val Glu Gly  Gly Ser Ser Glu Asn  Asn His Ser 
    2135                 2140                 2145             


Ile Lys  Val Ser Pro Tyr Leu  Ser Gln Phe Gln Gln  Asp Lys Gln 
    2150                 2155                 2160             


Gln Leu  Val Leu Gly Thr Lys  Val Ser Leu Val Glu  Asn Ile His 
    2165                 2170                 2175             


Val Leu  Gly Lys Glu Gln Ala  Ser Pro Lys Asn Val  Lys Met Glu 
    2180                 2185                 2190             


Ile Gly  Lys Thr Glu Thr Phe  Ser Asp Val Pro Val  Lys Thr Asn 
    2195                 2200                 2205             


Ile Glu  Val Cys Ser Thr Tyr  Ser Lys Asp Ser Glu  Asn Tyr Phe 
    2210                 2215                 2220             


Glu Thr  Glu Ala Val Glu Ile  Ala Lys Ala Phe Met  Glu Asp Asp 
    2225                 2230                 2235             


Glu Leu  Thr Asp Ser Lys Leu  Pro Ser His Ala Thr  His Ser Leu 
    2240                 2245                 2250             


Phe Thr  Cys Pro Glu Asn Glu  Glu Met Val Leu Ser  Asn Ser Arg 
    2255                 2260                 2265             


Ile Gly  Lys Arg Arg Gly Glu  Pro Leu Ile Leu Val  Gly Glu Pro 
    2270                 2275                 2280             


Ser Ile  Lys Arg Asn Leu Leu  Asn Glu Phe Asp Arg  Ile Ile Glu 
    2285                 2290                 2295             


Asn Gln  Glu Lys Ser Leu Lys  Ala Ser Lys Ser Thr  Pro Asp Gly 
    2300                 2305                 2310             


Thr Ile  Lys Asp Arg Arg Leu  Phe Met His His Val  Ser Leu Glu 
    2315                 2320                 2325             


Pro Ile  Thr Cys Val Pro Phe  Arg Thr Thr Lys Glu  Arg Gln Glu 
    2330                 2335                 2340             


Ile Gln  Asn Pro Asn Phe Thr  Ala Pro Gly Gln Glu  Phe Leu Ser 
    2345                 2350                 2355             


Lys Ser  His Leu Tyr Glu His  Leu Thr Leu Glu Lys  Ser Ser Ser 
    2360                 2365                 2370             


Asn Leu  Ala Val Ser Gly His  Pro Phe Tyr Gln Val  Ser Ala Thr 
    2375                 2380                 2385             


Arg Asn  Glu Lys Met Arg His  Leu Ile Thr Thr Gly  Arg Pro Thr 
    2390                 2395                 2400             


Lys Val  Phe Val Pro Pro Phe  Lys Thr Lys Ser His  Phe His Arg 
    2405                 2410                 2415             


Val Glu  Gln Cys Val Arg Asn  Ile Asn Leu Glu Glu  Asn Arg Gln 
    2420                 2425                 2430             


Lys Gln  Asn Ile Asp Gly His  Gly Ser Asp Asp Ser  Lys Asn Lys 
    2435                 2440                 2445             


Ile Asn  Asp Asn Glu Ile His  Gln Phe Asn Lys Asn  Asn Ser Asn 
    2450                 2455                 2460             


Gln Ala  Ala Ala Val Thr Phe  Thr Lys Cys Glu Glu  Glu Pro Leu 
    2465                 2470                 2475             


Asp Leu  Ile Thr Ser Leu Gln  Asn Ala Arg Asp Ile  Gln Asp Met 
    2480                 2485                 2490             


Arg Ile  Lys Lys Lys Gln Arg  Gln Arg Val Phe Pro  Gln Pro Gly 
    2495                 2500                 2505             


Ser Leu  Tyr Leu Ala Lys Thr  Ser Thr Leu Pro Arg  Ile Ser Leu 
    2510                 2515                 2520             


Lys Ala  Ala Val Gly Gly Gln  Val Pro Ser Ala Cys  Ser His Lys 
    2525                 2530                 2535             


Gln Leu  Tyr Thr Tyr Gly Val  Ser Lys His Cys Ile  Lys Ile Asn 
    2540                 2545                 2550             


Ser Lys  Asn Ala Glu Ser Phe  Gln Phe His Thr Glu  Asp Tyr Phe 
    2555                 2560                 2565             


Gly Lys  Glu Ser Leu Trp Thr  Gly Lys Gly Ile Gln  Leu Ala Asp 
    2570                 2575                 2580             


Gly Gly  Trp Leu Ile Pro Ser  Asn Asp Gly Lys Ala  Gly Lys Glu 
    2585                 2590                 2595             


Glu Phe  Tyr Arg Ala Leu Cys  Asp Thr Pro Gly Val  Asp Pro Lys 
    2600                 2605                 2610             


Leu Ile  Ser Arg Ile Trp Val  Tyr Asn His Tyr Arg  Trp Ile Ile 
    2615                 2620                 2625             


Trp Lys  Leu Ala Ala Met Glu  Cys Ala Phe Pro Lys  Glu Phe Ala 
    2630                 2635                 2640             


Asn Arg  Cys Leu Ser Pro Glu  Arg Val Leu Leu Gln  Leu Lys Tyr 
    2645                 2650                 2655             


Arg Tyr  Asp Thr Glu Ile Asp  Arg Ser Arg Arg Ser  Ala Ile Lys 
    2660                 2665                 2670             


Lys Ile  Met Glu Arg Asp Asp  Thr Ala Ala Lys Thr  Leu Val Leu 
    2675                 2680                 2685             


Cys Val  Ser Asp Ile Ile Ser  Leu Ser Ala Asn Ile  Ser Glu Thr 
    2690                 2695                 2700             


Ser Ser  Asn Lys Thr Ser Ser  Ala Asp Thr Gln Lys  Val Ala Ile 
    2705                 2710                 2715             


Ile Glu  Leu Thr Asp Gly Trp  Tyr Ala Val Lys Ala  Gln Leu Asp 
    2720                 2725                 2730             


Pro Pro  Leu Leu Ala Val Leu  Lys Asn Gly Arg Leu  Thr Val Gly 
    2735                 2740                 2745             


Gln Lys  Ile Ile Leu His Gly  Ala Glu Leu Val Gly  Ser Pro Asp 
    2750                 2755                 2760             


Ala Cys  Thr Pro Leu Glu Ala  Pro Glu Ser Leu Met  Leu Lys Ile 
    2765                 2770                 2775             


Ser Ala  Asn Ser Thr Arg Pro  Ala Arg Trp Tyr Thr  Lys Leu Gly 
    2780                 2785                 2790             


Phe Phe  Pro Asp Pro Arg Pro  Phe Pro Leu Pro Leu  Ser Ser Leu 
    2795                 2800                 2805             


Phe Ser  Asp Gly Gly Asn Val  Gly Cys Val Asp Val  Ile Ile Gln 
    2810                 2815                 2820             


Arg Ala  Tyr Pro Ile Gln Trp  Met Glu Lys Thr Ser  Ser Gly Leu 
    2825                 2830                 2835             


Tyr Ile  Phe Arg Asn Glu Arg  Glu Glu Glu Lys Glu  Ala Ala Lys 
    2840                 2845                 2850             


Tyr Val  Glu Ala Gln Gln Lys  Arg Leu Glu Ala Leu  Phe Thr Lys 
    2855                 2860                 2865             


Ile Gln  Glu Glu Phe Glu Glu  His Glu Glu Asn Thr  Thr Lys Pro 
    2870                 2875                 2880             


Tyr Leu  Pro Ser Arg Ala Leu  Thr Arg Gln Gln Val  Arg Ala Leu 
    2885                 2890                 2895             


Gln Asp  Gly Ala Glu Leu Tyr  Glu Ala Val Lys Asn  Ala Ala Asp 
    2900                 2905                 2910             


Pro Ala  Tyr Leu Glu Gly Tyr  Phe Ser Glu Glu Gln  Leu Arg Ala 
    2915                 2920                 2925             


Leu Asn  Asn His Arg Gln Met  Leu Asn Asp Lys Lys  Gln Ala Gln 
    2930                 2935                 2940             


Ile Gln  Leu Glu Ile Arg Lys  Ala Met Glu Ser Ala  Glu Gln Lys 
    2945                 2950                 2955             


Glu Gln  Gly Leu Ser Arg Asp  Val Thr Thr Val Trp  Lys Leu Arg 
    2960                 2965                 2970             


Ile Val  Ser Tyr Ser Lys Lys  Glu Lys Asp Ser Val  Ile Leu Ser 
    2975                 2980                 2985             


Ile Trp  Arg Pro Ser Ser Asp  Leu Tyr Ser Leu Leu  Thr Glu Gly 
    2990                 2995                 3000             


Lys Arg  Tyr Arg Ile Tyr His  Leu Ala Thr Ser Lys  Ser Lys Ser 
    3005                 3010                 3015             


Lys Ser  Glu Arg Ala Asn Ile  Gln Leu Ala Ala Thr  Lys Lys Thr 
    3020                 3025                 3030             


Gln Tyr  Gln Gln Leu Pro Val  Ser Asp Glu Ile Leu  Phe Gln Ile 
    3035                 3040                 3045             


Tyr Gln  Pro Arg Glu Pro Leu  His Phe Ser Lys Phe  Leu Asp Pro 
    3050                 3055                 3060             


Asp Phe  Gln Pro Ser Cys Ser  Glu Val Asp Leu Ile  Gly Phe Val 
    3065                 3070                 3075             


Val Ser  Val Val Lys Lys Thr  Gly Leu Ala Pro Phe  Val Tyr Leu 
    3080                 3085                 3090             


Ser Asp  Glu Cys Tyr Asn Leu  Leu Ala Ile Lys Phe  Trp Ile Asp 
    3095                 3100                 3105             


Leu Asn  Glu Asp Ile Ile Lys  Pro His Met Leu Ile  Ala Ala Ser 
    3110                 3115                 3120             


Asn Leu  Gln Trp Arg Pro Glu  Ser Lys Ser Gly Leu  Leu Thr Leu 
    3125                 3130                 3135             


Phe Ala  Gly Asp Phe Ser Val  Phe Ser Ala Ser Pro  Lys Glu Gly 
    3140                 3145                 3150             


His Phe  Gln Glu Thr Phe Asn  Lys Met Lys Asn Thr  Val Glu Asn 
    3155                 3160                 3165             


Ile Asp  Ile Leu Cys Asn Glu  Ala Glu Asn Lys Leu  Met His Ile 
    3170                 3175                 3180             


Leu His  Ala Asn Asp Pro Lys  Trp Ser Thr Pro Thr  Lys Asp Cys 
    3185                 3190                 3195             


Thr Ser  Gly Pro Tyr Thr Ala  Gln Ile Ile Pro Gly  Thr Gly Asn 
    3200                 3205                 3210             


Lys Leu  Leu Met Ser Ser Pro  Asn Cys Glu Ile Tyr  Tyr Gln Ser 
    3215                 3220                 3225             


Pro Leu  Ser Leu Cys Met Ala  Lys Arg Lys Ser Val  Ser Thr Pro 
    3230                 3235                 3240             


Val Ser  Ala Gln Met Thr Ser  Lys Ser Cys Lys Gly  Glu Lys Glu 
    3245                 3250                 3255             


Ile Asp  Asp Gln Lys Asn Cys  Lys Lys Arg Arg Ala  Leu Asp Phe 
    3260                 3265                 3270             


Leu Ser  Arg Leu Pro Leu Pro  Pro Pro Val Ser Pro  Ile Cys Thr 
    3275                 3280                 3285             


Phe Val  Ser Pro Ala Ala Gln  Lys Ala Phe Gln Pro  Pro Arg Ser 
    3290                 3295                 3300             


Cys Gly  Thr Lys Tyr Glu Thr  Pro Ile Lys Lys Lys  Glu Leu Asn 
    3305                 3310                 3315             


Ser Pro  Gln Met Thr Pro Phe  Lys Lys Phe Asn Glu  Ile Ser Leu 
    3320                 3325                 3330             


Leu Glu  Ser Asn Ser Ile Ala  Asp Glu Glu Leu Ala  Leu Ile Asn 
    3335                 3340                 3345             


Thr Gln  Ala Leu Leu Ser Gly  Ser Thr Gly Glu Lys  Gln Phe Ile 
    3350                 3355                 3360             


Ser Val  Ser Glu Ser Thr Arg  Thr Ala Pro Thr Ser  Ser Glu Asp 
    3365                 3370                 3375             


Tyr Leu  Arg Leu Lys Arg Arg  Cys Thr Thr Ser Leu  Ile Lys Glu 
    3380                 3385                 3390             


Gln Glu  Ser Ser Gln Ala Ser  Thr Glu Glu Cys Glu  Lys Asn Lys 
    3395                 3400                 3405             


Gln Asp  Thr Ile Thr Thr Lys  Lys Tyr Ile 
    3410                 3415             


<210>  9
<211>  624
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gln Pro Asp Pro Arg Pro Ser Gly Ala Gly Ala Cys Cys Arg Phe 
1               5                   10                  15      


Leu Pro Leu Gln Ser Gln Cys Pro Glu Gly Ala Gly Asp Ala Val Met 
            20                  25                  30          


Tyr Ala Ser Thr Glu Cys Lys Ala Glu Val Thr Pro Ser Gln His Gly 
        35                  40                  45              


Asn Arg Thr Phe Ser Tyr Thr Leu Glu Asp His Thr Lys Gln Ala Phe 
    50                  55                  60                  


Gly Ile Met Asn Glu Leu Arg Leu Ser Gln Gln Leu Cys Asp Val Thr 
65                  70                  75                  80  


Leu Gln Val Lys Tyr Gln Asp Ala Pro Ala Ala Gln Phe Met Ala His 
                85                  90                  95      


Lys Val Val Leu Ala Ser Ser Ser Pro Val Phe Lys Ala Met Phe Thr 
            100                 105                 110         


Asn Gly Leu Arg Glu Gln Gly Met Glu Val Val Ser Ile Glu Gly Ile 
        115                 120                 125             


His Pro Lys Val Met Glu Arg Leu Ile Glu Phe Ala Tyr Thr Ala Ser 
    130                 135                 140                 


Ile Ser Met Gly Glu Lys Cys Val Leu His Val Met Asn Gly Ala Val 
145                 150                 155                 160 


Met Tyr Gln Ile Asp Ser Val Val Arg Ala Cys Ser Asp Phe Leu Val 
                165                 170                 175     


Gln Gln Leu Asp Pro Ser Asn Ala Ile Gly Ile Ala Asn Phe Ala Glu 
            180                 185                 190         


Gln Ile Gly Cys Val Glu Leu His Gln Arg Ala Arg Glu Tyr Ile Tyr 
        195                 200                 205             


Met His Phe Gly Glu Val Ala Lys Gln Glu Glu Phe Phe Asn Leu Ser 
    210                 215                 220                 


His Cys Gln Leu Val Thr Leu Ile Ser Arg Asp Asp Leu Asn Val Arg 
225                 230                 235                 240 


Cys Glu Ser Glu Val Phe His Ala Cys Ile Asn Trp Val Lys Tyr Asp 
                245                 250                 255     


Cys Glu Gln Arg Arg Phe Tyr Val Gln Ala Leu Leu Arg Ala Val Arg 
            260                 265                 270         


Cys His Ser Leu Thr Pro Asn Phe Leu Gln Met Gln Leu Gln Lys Cys 
        275                 280                 285             


Glu Ile Leu Gln Ser Asp Ser Arg Cys Lys Asp Tyr Leu Val Lys Ile 
    290                 295                 300                 


Phe Glu Glu Leu Thr Leu His Lys Pro Thr Gln Val Met Pro Cys Arg 
305                 310                 315                 320 


Ala Pro Lys Val Gly Arg Leu Ile Tyr Thr Ala Gly Gly Tyr Phe Arg 
                325                 330                 335     


Gln Ser Leu Ser Tyr Leu Glu Ala Tyr Asn Pro Ser Asp Gly Thr Trp 
            340                 345                 350         


Leu Arg Leu Ala Asp Leu Gln Val Pro Arg Ser Gly Leu Ala Gly Cys 
        355                 360                 365             


Val Val Gly Gly Leu Leu Tyr Ala Val Gly Gly Arg Asn Asn Ser Pro 
    370                 375                 380                 


Asp Gly Asn Thr Asp Ser Ser Ala Leu Asp Cys Tyr Asn Pro Met Thr 
385                 390                 395                 400 


Asn Gln Trp Ser Pro Cys Ala Pro Met Ser Val Pro Arg Asn Arg Ile 
                405                 410                 415     


Gly Val Gly Val Ile Asp Gly His Ile Tyr Ala Val Gly Gly Ser His 
            420                 425                 430         


Gly Cys Ile His His Asn Ser Val Glu Arg Tyr Glu Pro Glu Arg Asp 
        435                 440                 445             


Glu Trp His Leu Val Ala Pro Met Leu Thr Arg Arg Ile Gly Val Gly 
    450                 455                 460                 


Val Ala Val Leu Asn Arg Leu Leu Tyr Ala Val Gly Gly Phe Asp Gly 
465                 470                 475                 480 


Thr Asn Arg Leu Asn Ser Ala Glu Cys Tyr Tyr Pro Glu Arg Asn Glu 
                485                 490                 495     


Trp Arg Met Ile Thr Ala Met Asn Thr Ile Arg Ser Gly Ala Gly Val 
            500                 505                 510         


Cys Val Leu His Asn Cys Ile Tyr Ala Ala Gly Gly Tyr Asp Gly Gln 
        515                 520                 525             


Asp Gln Leu Asn Ser Val Glu Arg Tyr Asp Val Glu Thr Glu Thr Trp 
    530                 535                 540                 


Thr Phe Val Ala Pro Met Lys His Arg Arg Ser Ala Leu Gly Ile Thr 
545                 550                 555                 560 


Val His Gln Gly Arg Ile Tyr Val Leu Gly Gly Tyr Asp Gly His Thr 
                565                 570                 575     


Phe Leu Asp Ser Val Glu Cys Tyr Asp Pro Asp Thr Asp Thr Trp Ser 
            580                 585                 590         


Glu Val Thr Arg Met Thr Ser Gly Arg Ser Gly Val Gly Val Ala Val 
        595                 600                 605             


Thr Met Glu Pro Cys Arg Lys Gln Ile Asp Gln Gln Asn Cys Thr Cys 
    610                 615                 620                 


<210>  10
<211>  1977
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Gly Glu Gln Met Asp Pro Thr Gly Ser Gln Leu Asp Ser Asp 
1               5                   10                  15      


Phe Ser Gln Gln Asp Thr Pro Cys Leu Ile Ile Glu Asp Ser Gln Pro 
            20                  25                  30          


Glu Ser Gln Val Leu Glu Asp Asp Ser Gly Ser His Phe Ser Met Leu 
        35                  40                  45              


Ser Arg His Leu Pro Asn Leu Gln Thr His Lys Glu Asn Pro Val Leu 
    50                  55                  60                  


Asp Val Val Ser Asn Pro Glu Gln Thr Ala Gly Glu Glu Arg Gly Asp 
65                  70                  75                  80  


Gly Asn Ser Gly Phe Asn Glu His Leu Lys Glu Asn Lys Val Ala Asp 
                85                  90                  95      


Pro Val Asp Ser Ser Asn Leu Asp Thr Cys Gly Ser Ile Ser Gln Val 
            100                 105                 110         


Ile Glu Gln Leu Pro Gln Pro Asn Arg Thr Ser Ser Val Leu Gly Met 
        115                 120                 125             


Ser Val Glu Ser Ala Pro Ala Val Glu Glu Glu Lys Gly Glu Glu Leu 
    130                 135                 140                 


Glu Gln Lys Glu Lys Glu Lys Glu Glu Asp Thr Ser Gly Asn Thr Thr 
145                 150                 155                 160 


His Ser Leu Gly Ala Glu Asp Thr Ala Ser Ser Gln Leu Gly Phe Gly 
                165                 170                 175     


Val Leu Glu Leu Ser Gln Ser Gln Asp Val Glu Glu Asn Thr Val Pro 
            180                 185                 190         


Tyr Glu Val Asp Lys Glu Gln Leu Gln Ser Val Thr Thr Asn Ser Gly 
        195                 200                 205             


Tyr Thr Arg Leu Ser Asp Val Asp Ala Asn Thr Ala Ile Lys His Glu 
    210                 215                 220                 


Glu Gln Ser Asn Glu Asp Ile Pro Ile Ala Glu Gln Ser Ser Lys Asp 
225                 230                 235                 240 


Ile Pro Val Thr Ala Gln Pro Ser Lys Asp Val His Val Val Lys Glu 
                245                 250                 255     


Gln Asn Pro Pro Pro Ala Arg Ser Glu Asp Met Pro Phe Ser Pro Lys 
            260                 265                 270         


Ala Ser Val Ala Ala Met Glu Ala Lys Glu Gln Leu Ser Ala Gln Glu 
        275                 280                 285             


Leu Met Glu Ser Gly Leu Gln Ile Gln Lys Ser Pro Glu Pro Glu Val 
    290                 295                 300                 


Leu Ser Thr Gln Glu Asp Leu Phe Asp Gln Ser Asn Lys Thr Val Ser 
305                 310                 315                 320 


Ser Asp Gly Cys Ser Thr Pro Ser Arg Glu Glu Gly Gly Cys Ser Leu 
                325                 330                 335     


Ala Ser Thr Pro Ala Thr Thr Leu His Leu Leu Gln Leu Ser Gly Gln 
            340                 345                 350         


Arg Ser Leu Val Gln Asp Ser Leu Ser Thr Asn Ser Ser Asp Leu Val 
        355                 360                 365             


Ala Pro Ser Pro Asp Ala Phe Arg Ser Thr Pro Phe Ile Val Pro Ser 
    370                 375                 380                 


Ser Pro Thr Glu Gln Glu Gly Arg Gln Asp Lys Pro Met Asp Thr Ser 
385                 390                 395                 400 


Val Leu Ser Glu Glu Gly Gly Glu Pro Phe Gln Lys Lys Leu Gln Ser 
                405                 410                 415     


Gly Glu Pro Val Glu Leu Glu Asn Pro Pro Leu Leu Pro Glu Ser Thr 
            420                 425                 430         


Val Ser Pro Gln Ala Ser Thr Pro Ile Ser Gln Ser Thr Pro Val Phe 
        435                 440                 445             


Pro Pro Gly Ser Leu Pro Ile Pro Ser Gln Pro Gln Phe Ser His Asp 
    450                 455                 460                 


Ile Phe Ile Pro Ser Pro Ser Leu Glu Glu Gln Ser Asn Asp Gly Lys 
465                 470                 475                 480 


Lys Asp Gly Asp Met His Ser Ser Ser Leu Thr Val Glu Cys Ser Lys 
                485                 490                 495     


Thr Ser Glu Ile Glu Pro Lys Asn Ser Pro Glu Asp Leu Gly Leu Ser 
            500                 505                 510         


Leu Thr Gly Asp Ser Cys Lys Leu Met Leu Ser Thr Ser Glu Tyr Ser 
        515                 520                 525             


Gln Ser Pro Lys Met Glu Ser Leu Ser Ser His Arg Ile Asp Glu Asp 
    530                 535                 540                 


Gly Glu Asn Thr Gln Ile Glu Asp Thr Glu Pro Met Ser Pro Val Leu 
545                 550                 555                 560 


Asn Ser Lys Phe Val Pro Ala Glu Asn Asp Ser Ile Leu Met Asn Pro 
                565                 570                 575     


Ala Gln Asp Gly Glu Val Gln Leu Ser Gln Asn Asp Asp Lys Thr Lys 
            580                 585                 590         


Gly Asp Asp Thr Asp Thr Arg Asp Asp Ile Ser Ile Leu Ala Thr Gly 
        595                 600                 605             


Cys Lys Gly Arg Glu Glu Thr Val Ala Glu Asp Val Cys Ile Asp Leu 
    610                 615                 620                 


Thr Cys Asp Ser Gly Ser Gln Ala Val Pro Ser Pro Ala Thr Arg Ser 
625                 630                 635                 640 


Glu Ala Leu Ser Ser Val Leu Asp Gln Glu Glu Ala Met Glu Ile Lys 
                645                 650                 655     


Glu His His Pro Glu Glu Gly Ser Ser Gly Ser Glu Val Glu Glu Ile 
            660                 665                 670         


Pro Glu Thr Pro Cys Glu Ser Gln Gly Glu Glu Leu Lys Glu Glu Asn 
        675                 680                 685             


Met Glu Ser Val Pro Leu His Leu Ser Leu Thr Glu Thr Gln Ser Gln 
    690                 695                 700                 


Gly Leu Cys Leu Gln Lys Glu Met Pro Lys Lys Glu Cys Ser Glu Ala 
705                 710                 715                 720 


Met Glu Val Glu Thr Ser Val Ile Ser Ile Asp Ser Pro Gln Lys Leu 
                725                 730                 735     


Ala Ile Leu Asp Gln Glu Leu Glu His Lys Glu Gln Glu Ala Trp Glu 
            740                 745                 750         


Glu Ala Thr Ser Glu Asp Ser Ser Val Val Ile Val Asp Val Lys Glu 
        755                 760                 765             


Pro Ser Pro Arg Val Asp Val Ser Cys Glu Pro Leu Glu Gly Val Glu 
    770                 775                 780                 


Lys Cys Ser Asp Ser Gln Ser Trp Glu Asp Ile Ala Pro Glu Ile Glu 
785                 790                 795                 800 


Pro Cys Ala Glu Asn Arg Leu Asp Thr Lys Glu Glu Lys Ser Val Glu 
                805                 810                 815     


Tyr Glu Gly Asp Leu Lys Ser Gly Thr Ala Glu Thr Glu Pro Val Glu 
            820                 825                 830         


Gln Asp Ser Ser Gln Pro Ser Leu Pro Leu Val Arg Ala Asp Asp Pro 
        835                 840                 845             


Leu Arg Leu Asp Gln Glu Leu Gln Gln Pro Gln Thr Gln Glu Lys Thr 
    850                 855                 860                 


Ser Asn Ser Leu Thr Glu Asp Ser Lys Met Ala Asn Ala Lys Gln Leu 
865                 870                 875                 880 


Ser Ser Asp Ala Glu Ala Gln Lys Leu Gly Lys Pro Ser Ala His Ala 
                885                 890                 895     


Ser Gln Ser Phe Cys Glu Ser Ser Ser Glu Thr Pro Phe His Phe Thr 
            900                 905                 910         


Leu Pro Lys Glu Gly Asp Ile Ile Pro Pro Leu Thr Gly Ala Thr Pro 
        915                 920                 925             


Pro Leu Ile Gly His Leu Lys Leu Glu Pro Lys Arg His Ser Thr Pro 
    930                 935                 940                 


Ile Gly Ile Ser Asn Tyr Pro Glu Ser Thr Ile Ala Thr Ser Asp Val 
945                 950                 955                 960 


Met Ser Glu Ser Met Val Glu Thr His Asp Pro Ile Leu Gly Ser Gly 
                965                 970                 975     


Lys Gly Asp Ser Gly Ala Ala Pro Asp Val Asp Asp Lys Leu Cys Leu 
            980                 985                 990         


Arg Met Lys Leu Val Ser Pro Glu  Thr Glu Ala Ser Glu  Glu Ser Leu 
        995                 1000                 1005             


Gln Phe  Asn Leu Glu Lys Pro  Ala Thr Gly Glu Arg  Lys Asn Gly 
    1010                 1015                 1020             


Ser Thr  Ala Val Ala Glu Ser  Val Ala Ser Pro Gln  Lys Thr Met 
    1025                 1030                 1035             


Ser Val  Leu Ser Cys Ile Cys  Glu Ala Arg Gln Glu  Asn Glu Ala 
    1040                 1045                 1050             


Arg Ser  Glu Asp Pro Pro Thr  Thr Pro Ile Arg Gly  Asn Leu Leu 
    1055                 1060                 1065             


His Phe  Pro Ser Ser Gln Gly  Glu Glu Glu Lys Glu  Lys Leu Glu 
    1070                 1075                 1080             


Gly Asp  His Thr Ile Arg Gln  Ser Gln Gln Pro Met  Lys Pro Ile 
    1085                 1090                 1095             


Ser Pro  Val Lys Asp Pro Val  Ser Pro Ala Ser Gln  Lys Met Val 
    1100                 1105                 1110             


Ile Gln  Gly Pro Ser Ser Pro  Gln Gly Glu Ala Met  Val Thr Asp 
    1115                 1120                 1125             


Val Leu  Glu Asp Gln Lys Glu  Gly Arg Ser Thr Asn  Lys Glu Asn 
    1130                 1135                 1140             


Pro Ser  Lys Ala Leu Ile Glu  Arg Pro Ser Gln Asn  Asn Ile Gly 
    1145                 1150                 1155             


Ile Gln  Thr Met Glu Cys Ser  Leu Arg Val Pro Glu  Thr Val Ser 
    1160                 1165                 1170             


Ala Ala  Thr Gln Thr Ile Lys  Asn Val Cys Glu Gln  Gly Thr Ser 
    1175                 1180                 1185             


Thr Val  Asp Gln Asn Phe Gly  Lys Gln Asp Ala Thr  Val Gln Thr 
    1190                 1195                 1200             


Glu Arg  Gly Ser Gly Glu Lys  Pro Val Ser Ala Pro  Gly Asp Asp 
    1205                 1210                 1215             


Thr Glu  Ser Leu His Ser Gln  Gly Glu Glu Glu Phe  Asp Met Pro 
    1220                 1225                 1230             


Gln Pro  Pro His Gly His Val  Leu His Arg His Met  Arg Thr Ile 
    1235                 1240                 1245             


Arg Glu  Val Arg Thr Leu Val  Thr Arg Val Ile Thr  Asp Val Tyr 
    1250                 1255                 1260             


Tyr Val  Asp Gly Thr Glu Val  Glu Arg Lys Val Thr  Glu Glu Thr 
    1265                 1270                 1275             


Glu Glu  Pro Ile Val Glu Cys  Gln Glu Cys Glu Thr  Glu Val Ser 
    1280                 1285                 1290             


Pro Ser  Gln Thr Gly Gly Ser  Ser Gly Asp Leu Gly  Asp Ile Ser 
    1295                 1300                 1305             


Ser Phe  Ser Ser Lys Ala Ser  Ser Leu His Arg Thr  Ser Ser Gly 
    1310                 1315                 1320             


Thr Ser  Leu Ser Ala Met His  Ser Ser Gly Ser Ser  Gly Lys Gly 
    1325                 1330                 1335             


Ala Gly  Pro Leu Arg Gly Lys  Thr Ser Gly Thr Glu  Pro Ala Asp 
    1340                 1345                 1350             


Phe Ala  Leu Pro Ser Ser Arg  Gly Gly Pro Gly Lys  Leu Ser Pro 
    1355                 1360                 1365             


Arg Lys  Gly Val Ser Gln Thr  Gly Thr Pro Val Cys  Glu Glu Asp 
    1370                 1375                 1380             


Gly Asp  Ala Gly Leu Gly Ile  Arg Gln Gly Gly Lys  Ala Pro Val 
    1385                 1390                 1395             


Thr Pro  Arg Gly Arg Gly Arg  Arg Gly Arg Pro Pro  Ser Arg Thr 
    1400                 1405                 1410             


Thr Gly  Thr Arg Glu Thr Ala  Val Pro Gly Pro Leu  Gly Ile Glu 
    1415                 1420                 1425             


Asp Ile  Ser Pro Asn Leu Ser  Pro Asp Asp Lys Ser  Phe Ser Arg 
    1430                 1435                 1440             


Val Val  Pro Arg Val Pro Asp  Ser Thr Arg Arg Thr  Asp Val Gly 
    1445                 1450                 1455             


Ala Gly  Ala Leu Arg Arg Ser  Asp Ser Pro Glu Ile  Pro Phe Gln 
    1460                 1465                 1470             


Ala Ala  Ala Gly Pro Ser Asp  Gly Leu Asp Ala Ser  Ser Pro Gly 
    1475                 1480                 1485             


Asn Ser  Phe Val Gly Leu Arg  Val Val Ala Lys Trp  Ser Ser Asn 
    1490                 1495                 1500             


Gly Tyr  Phe Tyr Ser Gly Lys  Ile Thr Arg Asp Val  Gly Ala Gly 
    1505                 1510                 1515             


Lys Tyr  Lys Leu Leu Phe Asp  Asp Gly Tyr Glu Cys  Asp Val Leu 
    1520                 1525                 1530             


Gly Lys  Asp Ile Leu Leu Cys  Asp Pro Ile Pro Leu  Asp Thr Glu 
    1535                 1540                 1545             


Val Thr  Ala Leu Ser Glu Asp  Glu Tyr Phe Ser Ala  Gly Val Val 
    1550                 1555                 1560             


Lys Gly  His Arg Lys Glu Ser  Gly Glu Leu Tyr Tyr  Ser Ile Glu 
    1565                 1570                 1575             


Lys Glu  Gly Gln Arg Lys Trp  Tyr Lys Arg Met Ala  Val Ile Leu 
    1580                 1585                 1590             


Ser Leu  Glu Gln Gly Asn Arg  Leu Arg Glu Gln Tyr  Gly Leu Gly 
    1595                 1600                 1605             


Pro Tyr  Glu Ala Val Thr Pro  Leu Thr Lys Ala Ala  Asp Ile Ser 
    1610                 1615                 1620             


Leu Asp  Asn Leu Val Glu Gly  Lys Arg Lys Arg Arg  Ser Asn Val 
    1625                 1630                 1635             


Ser Ser  Pro Ala Thr Pro Thr  Ala Ser Ser Ser Ser  Ser Thr Thr 
    1640                 1645                 1650             


Pro Thr  Arg Lys Ile Thr Glu  Ser Pro Arg Ala Ser  Met Gly Val 
    1655                 1660                 1665             


Leu Ser  Gly Lys Arg Lys Leu  Ile Thr Ser Glu Glu  Glu Arg Ser 
    1670                 1675                 1680             


Pro Ala  Lys Arg Gly Arg Lys  Ser Ala Thr Val Lys  Pro Gly Ala 
    1685                 1690                 1695             


Val Gly  Ala Gly Glu Phe Val  Ser Pro Cys Glu Ser  Gly Asp Asn 
    1700                 1705                 1710             


Thr Gly  Glu Pro Ser Ala Leu  Glu Glu Gln Arg Gly  Pro Leu Pro 
    1715                 1720                 1725             


Leu Asn  Lys Thr Leu Phe Leu  Gly Tyr Ala Phe Leu  Leu Thr Met 
    1730                 1735                 1740             


Ala Thr  Thr Ser Asp Lys Leu  Ala Ser Arg Ser Lys  Leu Pro Asp 
    1745                 1750                 1755             


Gly Pro  Thr Gly Ser Ser Glu  Glu Glu Glu Glu Phe  Leu Glu Ile 
    1760                 1765                 1770             


Pro Pro  Phe Asn Lys Gln Tyr  Thr Glu Ser Gln Leu  Arg Ala Gly 
    1775                 1780                 1785             


Ala Gly  Tyr Ile Leu Glu Asp  Phe Asn Glu Ala Gln  Cys Asn Thr 
    1790                 1795                 1800             


Ala Tyr  Gln Cys Leu Leu Ile  Ala Asp Gln His Cys  Arg Thr Arg 
    1805                 1810                 1815             


Lys Tyr  Phe Leu Cys Leu Ala  Ser Gly Ile Pro Cys  Val Ser His 
    1820                 1825                 1830             


Val Trp  Val His Asp Ser Cys  His Ala Asn Gln Leu  Gln Asn Tyr 
    1835                 1840                 1845             


Arg Asn  Tyr Leu Leu Pro Ala  Gly Tyr Ser Leu Glu  Glu Gln Arg 
    1850                 1855                 1860             


Ile Leu  Asp Trp Gln Pro Arg  Glu Asn Pro Phe Gln  Asn Leu Lys 
    1865                 1870                 1875             


Val Leu  Leu Val Ser Asp Gln  Gln Gln Asn Phe Leu  Glu Leu Trp 
    1880                 1885                 1890             


Ser Glu  Ile Leu Met Thr Gly  Gly Ala Ala Ser Val  Lys Gln His 
    1895                 1900                 1905             


His Ser  Ser Ala His Asn Lys  Asp Ile Ala Leu Gly  Val Phe Asp 
    1910                 1915                 1920             


Val Val  Val Thr Asp Pro Ser  Cys Pro Ala Ser Val  Leu Lys Cys 
    1925                 1930                 1935             


Ala Glu  Ala Leu Gln Leu Pro  Val Val Ser Gln Glu  Trp Val Ile 
    1940                 1945                 1950             


Gln Cys  Leu Ile Val Gly Glu  Arg Ile Gly Phe Lys  Gln His Pro 
    1955                 1960                 1965             


Lys Tyr  Lys His Asp Tyr Val  Ser His 
    1970                 1975         


<210>  11
<211>  1975
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Gly Glu Gln Met Asp Pro Thr Gly Ser Gln Leu Asp Ser Asp 
1               5                   10                  15      


Phe Ser Gln Gln Asp Thr Pro Cys Leu Ile Ile Glu Asp Ser Gln Pro 
            20                  25                  30          


Glu Ser Gln Val Leu Glu Asp Asp Ser Gly Ser His Phe Ser Met Leu 
        35                  40                  45              


Ser Arg His Leu Pro Asn Leu Gln Thr His Lys Glu Asn Pro Val Leu 
    50                  55                  60                  


Asp Val Val Ser Asn Pro Glu Gln Thr Ala Gly Glu Glu Arg Gly Asp 
65                  70                  75                  80  


Gly Asn Ser Gly Phe Asn Glu His Leu Lys Glu Asn Lys Val Ala Asp 
                85                  90                  95      


Pro Val Asp Ser Ser Asn Leu Asp Thr Cys Gly Ser Ile Ser Gln Val 
            100                 105                 110         


Ile Glu Gln Leu Pro Gln Pro Asn Arg Thr Ser Ser Val Leu Gly Met 
        115                 120                 125             


Ser Val Glu Ser Ala Pro Ala Val Glu Glu Glu Lys Gly Glu Glu Leu 
    130                 135                 140                 


Glu Gln Lys Glu Lys Glu Lys Glu Glu Asp Thr Ser Gly Asn Thr Thr 
145                 150                 155                 160 


His Ser Leu Gly Ala Glu Asp Thr Ala Ser Ser Gln Leu Gly Phe Gly 
                165                 170                 175     


Val Leu Glu Leu Ser Gln Ser Gln Asp Val Glu Glu Asn Thr Val Pro 
            180                 185                 190         


Tyr Glu Val Asp Lys Glu Gln Leu Gln Ser Val Thr Thr Asn Ser Gly 
        195                 200                 205             


Tyr Thr Arg Leu Ser Asp Val Asp Ala Asn Thr Ala Ile Lys His Glu 
    210                 215                 220                 


Glu Gln Ser Asn Glu Asp Ile Pro Ile Ala Glu Gln Ser Ser Lys Asp 
225                 230                 235                 240 


Ile Pro Val Thr Ala Gln Pro Ser Lys Asp Val His Val Val Lys Glu 
                245                 250                 255     


Gln Asn Pro Pro Pro Ala Arg Ser Glu Asp Met Pro Phe Ser Pro Lys 
            260                 265                 270         


Ala Ser Val Ala Ala Met Glu Ala Lys Glu Gln Leu Ser Ala Gln Glu 
        275                 280                 285             


Leu Met Glu Ser Gly Leu Gln Ile Gln Lys Ser Pro Glu Pro Glu Val 
    290                 295                 300                 


Leu Ser Thr Gln Glu Asp Leu Phe Asp Gln Ser Asn Lys Thr Val Ser 
305                 310                 315                 320 


Ser Asp Gly Cys Ser Thr Pro Ser Arg Glu Glu Gly Gly Cys Ser Leu 
                325                 330                 335     


Ala Ser Thr Pro Ala Thr Thr Leu His Leu Leu Gln Leu Ser Gly Gln 
            340                 345                 350         


Arg Ser Leu Val Gln Asp Ser Leu Ser Thr Asn Ser Ser Asp Leu Val 
        355                 360                 365             


Ala Pro Ser Pro Asp Ala Phe Arg Ser Thr Pro Phe Ile Val Pro Ser 
    370                 375                 380                 


Ser Pro Thr Glu Gln Glu Gly Arg Gln Asp Lys Pro Met Asp Thr Ser 
385                 390                 395                 400 


Val Leu Ser Glu Glu Gly Gly Glu Pro Phe Gln Lys Lys Leu Gln Ser 
                405                 410                 415     


Gly Glu Pro Val Glu Leu Glu Asn Pro Pro Leu Leu Pro Glu Ser Thr 
            420                 425                 430         


Val Ser Pro Gln Ala Ser Thr Pro Ile Ser Gln Ser Thr Pro Val Phe 
        435                 440                 445             


Pro Pro Gly Ser Leu Pro Ile Pro Ser Gln Pro Gln Phe Ser His Asp 
    450                 455                 460                 


Ile Phe Ile Pro Ser Pro Ser Leu Glu Glu Gln Ser Asn Asp Gly Lys 
465                 470                 475                 480 


Lys Asp Gly Asp Met His Ser Ser Ser Leu Thr Val Glu Cys Ser Lys 
                485                 490                 495     


Thr Ser Glu Ile Glu Pro Lys Asn Ser Pro Glu Asp Leu Gly Leu Ser 
            500                 505                 510         


Leu Thr Gly Asp Ser Cys Lys Leu Met Leu Ser Thr Ser Glu Tyr Ser 
        515                 520                 525             


Gln Ser Pro Lys Met Glu Ser Leu Ser Ser His Arg Ile Asp Glu Asp 
    530                 535                 540                 


Gly Glu Asn Thr Gln Ile Glu Asp Thr Glu Pro Met Ser Pro Val Leu 
545                 550                 555                 560 


Asn Ser Lys Phe Val Pro Ala Glu Asn Asp Ser Ile Leu Met Asn Pro 
                565                 570                 575     


Ala Gln Asp Gly Glu Val Gln Leu Ser Gln Asn Asp Asp Lys Thr Lys 
            580                 585                 590         


Gly Asp Asp Thr Asp Thr Arg Asp Asp Ile Ser Ile Leu Ala Thr Gly 
        595                 600                 605             


Cys Lys Gly Arg Glu Glu Thr Val Ala Glu Asp Val Cys Ile Asp Leu 
    610                 615                 620                 


Thr Cys Asp Ser Gly Ser Gln Ala Val Pro Ser Pro Ala Thr Arg Ser 
625                 630                 635                 640 


Glu Ala Leu Ser Ser Val Leu Asp Gln Glu Glu Ala Met Glu Ile Lys 
                645                 650                 655     


Glu His His Pro Glu Glu Gly Ser Ser Gly Ser Glu Val Glu Glu Ile 
            660                 665                 670         


Pro Glu Thr Pro Cys Glu Ser Gln Gly Glu Glu Leu Lys Glu Glu Asn 
        675                 680                 685             


Met Glu Ser Val Pro Leu His Leu Ser Leu Thr Glu Thr Gln Ser Gln 
    690                 695                 700                 


Gly Leu Cys Leu Gln Lys Glu Met Pro Lys Lys Glu Cys Ser Glu Ala 
705                 710                 715                 720 


Met Glu Val Glu Thr Ser Val Ile Ser Ile Asp Ser Pro Gln Lys Leu 
                725                 730                 735     


Ala Ile Leu Asp Gln Glu Leu Glu His Lys Glu Gln Glu Ala Trp Glu 
            740                 745                 750         


Glu Ala Thr Ser Glu Asp Ser Ser Val Val Ile Val Asp Val Lys Glu 
        755                 760                 765             


Pro Ser Pro Arg Val Asp Val Ser Cys Glu Pro Leu Glu Gly Val Glu 
    770                 775                 780                 


Lys Cys Ser Asp Ser Gln Ser Trp Glu Asp Ile Ala Pro Glu Ile Glu 
785                 790                 795                 800 


Pro Cys Ala Glu Asn Arg Leu Asp Thr Lys Glu Glu Lys Ser Val Glu 
                805                 810                 815     


Tyr Glu Gly Asp Leu Lys Ser Gly Thr Ala Glu Thr Glu Pro Val Glu 
            820                 825                 830         


Gln Asp Ser Ser Gln Pro Ser Leu Pro Leu Val Arg Ala Asp Asp Pro 
        835                 840                 845             


Leu Arg Leu Asp Gln Glu Leu Gln Gln Pro Gln Thr Gln Glu Lys Thr 
    850                 855                 860                 


Ser Asn Ser Leu Thr Glu Asp Ser Lys Met Ala Asn Ala Lys Gln Leu 
865                 870                 875                 880 


Ser Ser Asp Ala Glu Ala Gln Lys Leu Gly Lys Pro Ser Ala His Ala 
                885                 890                 895     


Ser Gln Ser Phe Cys Glu Ser Ser Ser Glu Thr Pro Phe His Phe Thr 
            900                 905                 910         


Leu Pro Lys Glu Gly Asp Ile Ile Pro Pro Leu Thr Gly Ala Thr Pro 
        915                 920                 925             


Pro Leu Ile Gly His Leu Lys Leu Glu Pro Lys Arg His Ser Thr Pro 
    930                 935                 940                 


Ile Gly Ile Ser Asn Tyr Pro Glu Ser Thr Ile Ala Thr Ser Asp Val 
945                 950                 955                 960 


Met Ser Glu Ser Met Val Glu Thr His Asp Pro Ile Leu Gly Ser Gly 
                965                 970                 975     


Lys Gly Asp Ser Gly Ala Ala Pro Asp Val Asp Asp Lys Leu Cys Leu 
            980                 985                 990         


Arg Met Lys Leu Val Ser Pro Glu  Thr Glu Ala Ser Glu  Glu Ser Leu 
        995                 1000                 1005             


Gln Phe  Asn Leu Glu Lys Pro  Ala Thr Gly Glu Arg  Lys Asn Gly 
    1010                 1015                 1020             


Ser Thr  Ala Val Ala Glu Ser  Val Ala Ser Pro Gln  Lys Thr Met 
    1025                 1030                 1035             


Ser Val  Leu Ser Cys Ile Cys  Glu Ala Arg Gln Glu  Asn Glu Ala 
    1040                 1045                 1050             


Arg Ser  Glu Asp Pro Pro Thr  Thr Pro Ile Arg Gly  Asn Leu Leu 
    1055                 1060                 1065             


His Phe  Pro Ser Ser Gln Gly  Glu Glu Glu Lys Glu  Lys Leu Glu 
    1070                 1075                 1080             


Gly Asp  His Thr Ile Arg Gln  Ser Gln Gln Pro Met  Lys Pro Ile 
    1085                 1090                 1095             


Ser Pro  Val Lys Asp Pro Val  Ser Pro Ala Ser Gln  Lys Met Val 
    1100                 1105                 1110             


Ile Gln  Gly Pro Ser Ser Pro  Gln Gly Glu Ala Met  Val Thr Asp 
    1115                 1120                 1125             


Val Leu  Glu Asp Gln Lys Glu  Gly Arg Ser Thr Asn  Lys Glu Asn 
    1130                 1135                 1140             


Pro Ser  Lys Ala Leu Ile Glu  Arg Pro Ser Gln Asn  Asn Ile Gly 
    1145                 1150                 1155             


Ile Gln  Thr Met Glu Cys Ser  Leu Arg Val Pro Glu  Thr Val Ser 
    1160                 1165                 1170             


Ala Ala  Thr Gln Thr Ile Lys  Asn Val Cys Glu Gln  Gly Thr Ser 
    1175                 1180                 1185             


Thr Val  Asp Gln Asn Phe Gly  Lys Gln Asp Ala Thr  Val Gln Thr 
    1190                 1195                 1200             


Glu Arg  Gly Ser Gly Glu Lys  Pro Val Ser Ala Pro  Gly Asp Asp 
    1205                 1210                 1215             


Thr Glu  Ser Leu His Ser Gln  Gly Glu Glu Glu Phe  Asp Met Pro 
    1220                 1225                 1230             


Gln Pro  Pro His Gly His Val  Leu His Arg His Met  Arg Thr Ile 
    1235                 1240                 1245             


Arg Glu  Val Arg Thr Leu Val  Thr Arg Val Ile Thr  Asp Val Tyr 
    1250                 1255                 1260             


Tyr Val  Asp Gly Thr Glu Val  Glu Arg Lys Val Thr  Glu Glu Thr 
    1265                 1270                 1275             


Glu Glu  Pro Ile Val Glu Cys  Gln Glu Cys Glu Thr  Glu Val Ser 
    1280                 1285                 1290             


Pro Ser  Gln Thr Gly Gly Ser  Ser Gly Asp Leu Gly  Asp Ile Ser 
    1295                 1300                 1305             


Ser Phe  Ser Ser Lys Ala Ser  Ser Leu His Arg Thr  Ser Ser Gly 
    1310                 1315                 1320             


Thr Ser  Leu Ser Ala Met His  Ser Ser Gly Ser Ser  Gly Lys Gly 
    1325                 1330                 1335             


Ala Gly  Pro Leu Arg Gly Lys  Thr Ser Gly Thr Glu  Pro Ala Asp 
    1340                 1345                 1350             


Phe Ala  Leu Pro Ser Ser Arg  Gly Gly Pro Gly Lys  Leu Ser Pro 
    1355                 1360                 1365             


Arg Lys  Gly Val Ser Gln Thr  Gly Thr Pro Val Cys  Glu Glu Asp 
    1370                 1375                 1380             


Gly Asp  Ala Gly Leu Gly Ile  Arg Gln Gly Gly Lys  Ala Pro Val 
    1385                 1390                 1395             


Thr Pro  Arg Gly Arg Gly Arg  Arg Gly Arg Pro Pro  Ser Arg Thr 
    1400                 1405                 1410             


Thr Gly  Thr Arg Glu Thr Ala  Val Pro Gly Pro Leu  Gly Ile Glu 
    1415                 1420                 1425             


Asp Ile  Ser Pro Asn Leu Ser  Pro Asp Asp Lys Ser  Phe Ser Arg 
    1430                 1435                 1440             


Val Val  Pro Arg Val Pro Asp  Ser Thr Arg Arg Thr  Asp Val Gly 
    1445                 1450                 1455             


Ala Gly  Ala Leu Arg Arg Ser  Asp Ser Pro Glu Ile  Pro Phe Gln 
    1460                 1465                 1470             


Ala Ala  Ala Gly Pro Ser Asp  Gly Leu Asp Ala Ser  Ser Pro Gly 
    1475                 1480                 1485             


Asn Ser  Phe Val Gly Leu Arg  Val Val Ala Lys Trp  Ser Ser Asn 
    1490                 1495                 1500             


Gly Tyr  Phe Tyr Ser Gly Lys  Ile Thr Arg Asp Val  Gly Ala Gly 
    1505                 1510                 1515             


Lys Tyr  Lys Leu Leu Phe Asp  Asp Gly Tyr Glu Cys  Asp Val Leu 
    1520                 1525                 1530             


Gly Lys  Asp Ile Leu Leu Cys  Asp Pro Ile Pro Leu  Asp Thr Glu 
    1535                 1540                 1545             


Val Thr  Ala Leu Ser Glu Asp  Glu Tyr Phe Ser Ala  Gly Val Val 
    1550                 1555                 1560             


Lys Gly  His Arg Lys Glu Ser  Gly Glu Leu Tyr Tyr  Ser Ile Glu 
    1565                 1570                 1575             


Lys Glu  Gly Gln Arg Lys Trp  Tyr Lys Arg Met Ala  Val Ile Leu 
    1580                 1585                 1590             


Ser Leu  Glu Gln Gly Asn Arg  Leu Arg Glu Gln Tyr  Gly Leu Gly 
    1595                 1600                 1605             


Pro Tyr  Glu Ala Val Thr Pro  Leu Thr Lys Ala Ala  Asp Ile Ser 
    1610                 1615                 1620             


Leu Asp  Asn Leu Val Glu Gly  Lys Arg Lys Arg Arg  Ser Asn Val 
    1625                 1630                 1635             


Ser Ser  Pro Ala Thr Pro Thr  Ala Ser Ser Ser Ser  Ser Thr Thr 
    1640                 1645                 1650             


Pro Thr  Arg Lys Ile Thr Glu  Ser Pro Arg Ala Ser  Met Gly Val 
    1655                 1660                 1665             


Leu Ser  Gly Lys Arg Lys Leu  Ile Thr Ser Glu Glu  Glu Arg Ser 
    1670                 1675                 1680             


Pro Ala  Lys Arg Gly Arg Lys  Ser Ala Thr Val Lys  Pro Val Gly 
    1685                 1690                 1695             


Ala Gly  Glu Phe Val Ser Pro  Cys Glu Ser Gly Asp  Asn Thr Gly 
    1700                 1705                 1710             


Glu Pro  Ser Ala Leu Glu Glu  Gln Arg Gly Pro Leu  Pro Leu Asn 
    1715                 1720                 1725             


Lys Thr  Leu Phe Leu Gly Tyr  Ala Phe Leu Leu Thr  Met Ala Thr 
    1730                 1735                 1740             


Thr Ser  Asp Lys Leu Ala Ser  Arg Ser Lys Leu Pro  Asp Gly Pro 
    1745                 1750                 1755             


Thr Gly  Ser Ser Glu Glu Glu  Glu Glu Phe Leu Glu  Ile Pro Pro 
    1760                 1765                 1770             


Phe Asn  Lys Gln Tyr Thr Glu  Ser Gln Leu Arg Ala  Gly Ala Gly 
    1775                 1780                 1785             


Tyr Ile  Leu Glu Asp Phe Asn  Glu Ala Gln Cys Asn  Thr Ala Tyr 
    1790                 1795                 1800             


Gln Cys  Leu Leu Ile Ala Asp  Gln His Cys Arg Thr  Arg Lys Tyr 
    1805                 1810                 1815             


Phe Leu  Cys Leu Ala Ser Gly  Ile Pro Cys Val Ser  His Val Trp 
    1820                 1825                 1830             


Val His  Asp Ser Cys His Ala  Asn Gln Leu Gln Asn  Tyr Arg Asn 
    1835                 1840                 1845             


Tyr Leu  Leu Pro Ala Gly Tyr  Ser Leu Glu Glu Gln  Arg Ile Leu 
    1850                 1855                 1860             


Asp Trp  Gln Pro Arg Glu Asn  Pro Phe Gln Asn Leu  Lys Val Leu 
    1865                 1870                 1875             


Leu Val  Ser Asp Gln Gln Gln  Asn Phe Leu Glu Leu  Trp Ser Glu 
    1880                 1885                 1890             


Ile Leu  Met Thr Gly Gly Ala  Ala Ser Val Lys Gln  His His Ser 
    1895                 1900                 1905             


Ser Ala  His Asn Lys Asp Ile  Ala Leu Gly Val Phe  Asp Val Val 
    1910                 1915                 1920             


Val Thr  Asp Pro Ser Cys Pro  Ala Ser Val Leu Lys  Cys Ala Glu 
    1925                 1930                 1935             


Ala Leu  Gln Leu Pro Val Val  Ser Gln Glu Trp Val  Ile Gln Cys 
    1940                 1945                 1950             


Leu Ile  Val Gly Glu Arg Ile  Gly Phe Lys Gln His  Pro Lys Tyr 
    1955                 1960                 1965             


Lys His  Asp Tyr Val Ser His  
    1970                 1975 


<210>  12
<211>  1972
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Pro Thr Gly Ser Gln Leu Asp Ser Asp Phe Ser Gln Gln Asp 
1               5                   10                  15      


Thr Pro Cys Leu Ile Ile Glu Asp Ser Gln Pro Glu Ser Gln Val Leu 
            20                  25                  30          


Glu Asp Asp Ser Gly Ser His Phe Ser Met Leu Ser Arg His Leu Pro 
        35                  40                  45              


Asn Leu Gln Thr His Lys Glu Asn Pro Val Leu Asp Val Val Ser Asn 
    50                  55                  60                  


Pro Glu Gln Thr Ala Gly Glu Glu Arg Gly Asp Gly Asn Ser Gly Phe 
65                  70                  75                  80  


Asn Glu His Leu Lys Glu Asn Lys Val Ala Asp Pro Val Asp Ser Ser 
                85                  90                  95      


Asn Leu Asp Thr Cys Gly Ser Ile Ser Gln Val Ile Glu Gln Leu Pro 
            100                 105                 110         


Gln Pro Asn Arg Thr Ser Ser Val Leu Gly Met Ser Val Glu Ser Ala 
        115                 120                 125             


Pro Ala Val Glu Glu Glu Lys Gly Glu Glu Leu Glu Gln Lys Glu Lys 
    130                 135                 140                 


Glu Lys Glu Glu Asp Thr Ser Gly Asn Thr Thr His Ser Leu Gly Ala 
145                 150                 155                 160 


Glu Asp Thr Ala Ser Ser Gln Leu Gly Phe Gly Val Leu Glu Leu Ser 
                165                 170                 175     


Gln Ser Gln Asp Val Glu Glu Asn Thr Val Pro Tyr Glu Val Asp Lys 
            180                 185                 190         


Glu Gln Leu Gln Ser Val Thr Thr Asn Ser Gly Tyr Thr Arg Leu Ser 
        195                 200                 205             


Asp Val Asp Ala Asn Thr Ala Ile Lys His Glu Glu Gln Ser Asn Glu 
    210                 215                 220                 


Asp Ile Pro Ile Ala Glu Gln Ser Ser Lys Asp Ile Pro Val Thr Ala 
225                 230                 235                 240 


Gln Pro Ser Lys Asp Val His Val Val Lys Glu Gln Asn Pro Pro Pro 
                245                 250                 255     


Ala Arg Ser Glu Asp Met Pro Phe Ser Pro Lys Ala Ser Val Ala Ala 
            260                 265                 270         


Met Glu Ala Lys Glu Gln Leu Ser Ala Gln Glu Leu Met Glu Ser Gly 
        275                 280                 285             


Leu Gln Ile Gln Lys Ser Pro Glu Pro Glu Val Leu Ser Thr Gln Glu 
    290                 295                 300                 


Asp Leu Phe Asp Gln Ser Asn Lys Thr Val Ser Ser Asp Gly Cys Ser 
305                 310                 315                 320 


Thr Pro Ser Arg Glu Glu Gly Gly Cys Ser Leu Ala Ser Thr Pro Ala 
                325                 330                 335     


Thr Thr Leu His Leu Leu Gln Leu Ser Gly Gln Arg Ser Leu Val Gln 
            340                 345                 350         


Asp Ser Leu Ser Thr Asn Ser Ser Asp Leu Val Ala Pro Ser Pro Asp 
        355                 360                 365             


Ala Phe Arg Ser Thr Pro Phe Ile Val Pro Ser Ser Pro Thr Glu Gln 
    370                 375                 380                 


Glu Gly Arg Gln Asp Lys Pro Met Asp Thr Ser Val Leu Ser Glu Glu 
385                 390                 395                 400 


Gly Gly Glu Pro Phe Gln Lys Lys Leu Gln Ser Gly Glu Pro Val Glu 
                405                 410                 415     


Leu Glu Asn Pro Pro Leu Leu Pro Glu Ser Thr Val Ser Pro Gln Ala 
            420                 425                 430         


Ser Thr Pro Ile Ser Gln Ser Thr Pro Val Phe Pro Pro Gly Ser Leu 
        435                 440                 445             


Pro Ile Pro Ser Gln Pro Gln Phe Ser His Asp Ile Phe Ile Pro Ser 
    450                 455                 460                 


Pro Ser Leu Glu Glu Gln Ser Asn Asp Gly Lys Lys Asp Gly Asp Met 
465                 470                 475                 480 


His Ser Ser Ser Leu Thr Val Glu Cys Ser Lys Thr Ser Glu Ile Glu 
                485                 490                 495     


Pro Lys Asn Ser Pro Glu Asp Leu Gly Leu Ser Leu Thr Gly Asp Ser 
            500                 505                 510         


Cys Lys Leu Met Leu Ser Thr Ser Glu Tyr Ser Gln Ser Pro Lys Met 
        515                 520                 525             


Glu Ser Leu Ser Ser His Arg Ile Asp Glu Asp Gly Glu Asn Thr Gln 
    530                 535                 540                 


Ile Glu Asp Thr Glu Pro Met Ser Pro Val Leu Asn Ser Lys Phe Val 
545                 550                 555                 560 


Pro Ala Glu Asn Asp Ser Ile Leu Met Asn Pro Ala Gln Asp Gly Glu 
                565                 570                 575     


Val Gln Leu Ser Gln Asn Asp Asp Lys Thr Lys Gly Asp Asp Thr Asp 
            580                 585                 590         


Thr Arg Asp Asp Ile Ser Ile Leu Ala Thr Gly Cys Lys Gly Arg Glu 
        595                 600                 605             


Glu Thr Val Ala Glu Asp Val Cys Ile Asp Leu Thr Cys Asp Ser Gly 
    610                 615                 620                 


Ser Gln Ala Val Pro Ser Pro Ala Thr Arg Ser Glu Ala Leu Ser Ser 
625                 630                 635                 640 


Val Leu Asp Gln Glu Glu Ala Met Glu Ile Lys Glu His His Pro Glu 
                645                 650                 655     


Glu Gly Ser Ser Gly Ser Glu Val Glu Glu Ile Pro Glu Thr Pro Cys 
            660                 665                 670         


Glu Ser Gln Gly Glu Glu Leu Lys Glu Glu Asn Met Glu Ser Val Pro 
        675                 680                 685             


Leu His Leu Ser Leu Thr Glu Thr Gln Ser Gln Gly Leu Cys Leu Gln 
    690                 695                 700                 


Lys Glu Met Pro Lys Lys Glu Cys Ser Glu Ala Met Glu Val Glu Thr 
705                 710                 715                 720 


Ser Val Ile Ser Ile Asp Ser Pro Gln Lys Leu Ala Ile Leu Asp Gln 
                725                 730                 735     


Glu Leu Glu His Lys Glu Gln Glu Ala Trp Glu Glu Ala Thr Ser Glu 
            740                 745                 750         


Asp Ser Ser Val Val Ile Val Asp Val Lys Glu Pro Ser Pro Arg Val 
        755                 760                 765             


Asp Val Ser Cys Glu Pro Leu Glu Gly Val Glu Lys Cys Ser Asp Ser 
    770                 775                 780                 


Gln Ser Trp Glu Asp Ile Ala Pro Glu Ile Glu Pro Cys Ala Glu Asn 
785                 790                 795                 800 


Arg Leu Asp Thr Lys Glu Glu Lys Ser Val Glu Tyr Glu Gly Asp Leu 
                805                 810                 815     


Lys Ser Gly Thr Ala Glu Thr Glu Pro Val Glu Gln Asp Ser Ser Gln 
            820                 825                 830         


Pro Ser Leu Pro Leu Val Arg Ala Asp Asp Pro Leu Arg Leu Asp Gln 
        835                 840                 845             


Glu Leu Gln Gln Pro Gln Thr Gln Glu Lys Thr Ser Asn Ser Leu Thr 
    850                 855                 860                 


Glu Asp Ser Lys Met Ala Asn Ala Lys Gln Leu Ser Ser Asp Ala Glu 
865                 870                 875                 880 


Ala Gln Lys Leu Gly Lys Pro Ser Ala His Ala Ser Gln Ser Phe Cys 
                885                 890                 895     


Glu Ser Ser Ser Glu Thr Pro Phe His Phe Thr Leu Pro Lys Glu Gly 
            900                 905                 910         


Asp Ile Ile Pro Pro Leu Thr Gly Ala Thr Pro Pro Leu Ile Gly His 
        915                 920                 925             


Leu Lys Leu Glu Pro Lys Arg His Ser Thr Pro Ile Gly Ile Ser Asn 
    930                 935                 940                 


Tyr Pro Glu Ser Thr Ile Ala Thr Ser Asp Val Met Ser Glu Ser Met 
945                 950                 955                 960 


Val Glu Thr His Asp Pro Ile Leu Gly Ser Gly Lys Gly Asp Ser Gly 
                965                 970                 975     


Ala Ala Pro Asp Val Asp Asp Lys Leu Cys Leu Arg Met Lys Leu Val 
            980                 985                 990         


Ser Pro Glu Thr Glu Ala Ser Glu  Glu Ser Leu Gln Phe  Asn Leu Glu 
        995                 1000                 1005             


Lys Pro  Ala Thr Gly Glu Arg  Lys Asn Gly Ser Thr  Ala Val Ala 
    1010                 1015                 1020             


Glu Ser  Val Ala Ser Pro Gln  Lys Thr Met Ser Val  Leu Ser Cys 
    1025                 1030                 1035             


Ile Cys  Glu Ala Arg Gln Glu  Asn Glu Ala Arg Ser  Glu Asp Pro 
    1040                 1045                 1050             


Pro Thr  Thr Pro Ile Arg Gly  Asn Leu Leu His Phe  Pro Ser Ser 
    1055                 1060                 1065             


Gln Gly  Glu Glu Glu Lys Glu  Lys Leu Glu Gly Asp  His Thr Ile 
    1070                 1075                 1080             


Arg Gln  Ser Gln Gln Pro Met  Lys Pro Ile Ser Pro  Val Lys Asp 
    1085                 1090                 1095             


Pro Val  Ser Pro Ala Ser Gln  Lys Met Val Ile Gln  Gly Pro Ser 
    1100                 1105                 1110             


Ser Pro  Gln Gly Glu Ala Met  Val Thr Asp Val Leu  Glu Asp Gln 
    1115                 1120                 1125             


Lys Glu  Gly Arg Ser Thr Asn  Lys Glu Asn Pro Ser  Lys Ala Leu 
    1130                 1135                 1140             


Ile Glu  Arg Pro Ser Gln Asn  Asn Ile Gly Ile Gln  Thr Met Glu 
    1145                 1150                 1155             


Cys Ser  Leu Arg Val Pro Glu  Thr Val Ser Ala Ala  Thr Gln Thr 
    1160                 1165                 1170             


Ile Lys  Asn Val Cys Glu Gln  Gly Thr Ser Thr Val  Asp Gln Asn 
    1175                 1180                 1185             


Phe Gly  Lys Gln Asp Ala Thr  Val Gln Thr Glu Arg  Gly Ser Gly 
    1190                 1195                 1200             


Glu Lys  Pro Val Ser Ala Pro  Gly Asp Asp Thr Glu  Ser Leu His 
    1205                 1210                 1215             


Ser Gln  Gly Glu Glu Glu Phe  Asp Met Pro Gln Pro  Pro His Gly 
    1220                 1225                 1230             


His Val  Leu His Arg His Met  Arg Thr Ile Arg Glu  Val Arg Thr 
    1235                 1240                 1245             


Leu Val  Thr Arg Val Ile Thr  Asp Val Tyr Tyr Val  Asp Gly Thr 
    1250                 1255                 1260             


Glu Val  Glu Arg Lys Val Thr  Glu Glu Thr Glu Glu  Pro Ile Val 
    1265                 1270                 1275             


Glu Cys  Gln Glu Cys Glu Thr  Glu Val Ser Pro Ser  Gln Thr Gly 
    1280                 1285                 1290             


Gly Ser  Ser Gly Asp Leu Gly  Asp Ile Ser Ser Phe  Ser Ser Lys 
    1295                 1300                 1305             


Ala Ser  Ser Leu His Arg Thr  Ser Ser Gly Thr Ser  Leu Ser Ala 
    1310                 1315                 1320             


Met His  Ser Ser Gly Ser Ser  Gly Lys Gly Ala Gly  Pro Leu Arg 
    1325                 1330                 1335             


Gly Lys  Thr Ser Gly Thr Glu  Pro Ala Asp Phe Ala  Leu Pro Ser 
    1340                 1345                 1350             


Ser Arg  Gly Gly Pro Gly Lys  Leu Ser Pro Arg Lys  Gly Val Ser 
    1355                 1360                 1365             


Gln Thr  Gly Thr Pro Val Cys  Glu Glu Asp Gly Asp  Ala Gly Leu 
    1370                 1375                 1380             


Gly Ile  Arg Gln Gly Gly Lys  Ala Pro Val Thr Pro  Arg Gly Arg 
    1385                 1390                 1395             


Gly Arg  Arg Gly Arg Pro Pro  Ser Arg Thr Thr Gly  Thr Arg Glu 
    1400                 1405                 1410             


Thr Ala  Val Pro Gly Pro Leu  Gly Ile Glu Asp Ile  Ser Pro Asn 
    1415                 1420                 1425             


Leu Ser  Pro Asp Asp Lys Ser  Phe Ser Arg Val Val  Pro Arg Val 
    1430                 1435                 1440             


Pro Asp  Ser Thr Arg Arg Thr  Asp Val Gly Ala Gly  Ala Leu Arg 
    1445                 1450                 1455             


Arg Ser  Asp Ser Pro Glu Ile  Pro Phe Gln Ala Ala  Ala Gly Pro 
    1460                 1465                 1470             


Ser Asp  Gly Leu Asp Ala Ser  Ser Pro Gly Asn Ser  Phe Val Gly 
    1475                 1480                 1485             


Leu Arg  Val Val Ala Lys Trp  Ser Ser Asn Gly Tyr  Phe Tyr Ser 
    1490                 1495                 1500             


Gly Lys  Ile Thr Arg Asp Val  Gly Ala Gly Lys Tyr  Lys Leu Leu 
    1505                 1510                 1515             


Phe Asp  Asp Gly Tyr Glu Cys  Asp Val Leu Gly Lys  Asp Ile Leu 
    1520                 1525                 1530             


Leu Cys  Asp Pro Ile Pro Leu  Asp Thr Glu Val Thr  Ala Leu Ser 
    1535                 1540                 1545             


Glu Asp  Glu Tyr Phe Ser Ala  Gly Val Val Lys Gly  His Arg Lys 
    1550                 1555                 1560             


Glu Ser  Gly Glu Leu Tyr Tyr  Ser Ile Glu Lys Glu  Gly Gln Arg 
    1565                 1570                 1575             


Lys Trp  Tyr Lys Arg Met Ala  Val Ile Leu Ser Leu  Glu Gln Gly 
    1580                 1585                 1590             


Asn Arg  Leu Arg Glu Gln Tyr  Gly Leu Gly Pro Tyr  Glu Ala Val 
    1595                 1600                 1605             


Thr Pro  Leu Thr Lys Ala Ala  Asp Ile Ser Leu Asp  Asn Leu Val 
    1610                 1615                 1620             


Glu Gly  Lys Arg Lys Arg Arg  Ser Asn Val Ser Ser  Pro Ala Thr 
    1625                 1630                 1635             


Pro Thr  Ala Ser Ser Ser Ser  Ser Thr Thr Pro Thr  Arg Lys Ile 
    1640                 1645                 1650             


Thr Glu  Ser Pro Arg Ala Ser  Met Gly Val Leu Ser  Gly Lys Arg 
    1655                 1660                 1665             


Lys Leu  Ile Thr Ser Glu Glu  Glu Arg Ser Pro Ala  Lys Arg Gly 
    1670                 1675                 1680             


Arg Lys  Ser Ala Thr Val Lys  Pro Gly Ala Val Gly  Ala Gly Glu 
    1685                 1690                 1695             


Phe Val  Ser Pro Cys Glu Ser  Gly Asp Asn Thr Gly  Glu Pro Ser 
    1700                 1705                 1710             


Ala Leu  Glu Glu Gln Arg Gly  Pro Leu Pro Leu Asn  Lys Thr Leu 
    1715                 1720                 1725             


Phe Leu  Gly Tyr Ala Phe Leu  Leu Thr Met Ala Thr  Thr Ser Asp 
    1730                 1735                 1740             


Lys Leu  Ala Ser Arg Ser Lys  Leu Pro Asp Gly Pro  Thr Gly Ser 
    1745                 1750                 1755             


Ser Glu  Glu Glu Glu Glu Phe  Leu Glu Ile Pro Pro  Phe Asn Lys 
    1760                 1765                 1770             


Gln Tyr  Thr Glu Ser Gln Leu  Arg Ala Gly Ala Gly  Tyr Ile Leu 
    1775                 1780                 1785             


Glu Asp  Phe Asn Glu Ala Gln  Cys Asn Thr Ala Tyr  Gln Cys Leu 
    1790                 1795                 1800             


Leu Ile  Ala Asp Gln His Cys  Arg Thr Arg Lys Tyr  Phe Leu Cys 
    1805                 1810                 1815             


Leu Ala  Ser Gly Ile Pro Cys  Val Ser His Val Trp  Val His Asp 
    1820                 1825                 1830             


Ser Cys  His Ala Asn Gln Leu  Gln Asn Tyr Arg Asn  Tyr Leu Leu 
    1835                 1840                 1845             


Pro Ala  Gly Tyr Ser Leu Glu  Glu Gln Arg Ile Leu  Asp Trp Gln 
    1850                 1855                 1860             


Pro Arg  Glu Asn Pro Phe Gln  Asn Leu Lys Val Leu  Leu Val Ser 
    1865                 1870                 1875             


Asp Gln  Gln Gln Asn Phe Leu  Glu Leu Trp Ser Glu  Ile Leu Met 
    1880                 1885                 1890             


Thr Gly  Gly Ala Ala Ser Val  Lys Gln His His Ser  Ser Ala His 
    1895                 1900                 1905             


Asn Lys  Asp Ile Ala Leu Gly  Val Phe Asp Val Val  Val Thr Asp 
    1910                 1915                 1920             


Pro Ser  Cys Pro Ala Ser Val  Leu Lys Cys Ala Glu  Ala Leu Gln 
    1925                 1930                 1935             


Leu Pro  Val Val Ser Gln Glu  Trp Val Ile Gln Cys  Leu Ile Val 
    1940                 1945                 1950             


Gly Glu  Arg Ile Gly Phe Lys  Gln His Pro Lys Tyr  Lys His Asp 
    1955                 1960                 1965             


Tyr Val  Ser His 
    1970         


<210>  13
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Phe Pro Phe Gly Pro His Ser Pro Gly Gly Asp Gly Ser Ala Gly 
1               5                   10                  15      


Ala Gly Ala Glu Glu Pro Thr Pro His Glu Gly Gln Ala Ala Ala Thr 
            20                  25                  30          


Gly Pro Pro Ser Pro Leu His Pro Gly Ala Asp Ala Thr His Pro Pro 
        35                  40                  45              


Pro Pro Ala Arg Ser Pro Arg Arg Pro Gly Ala Pro Ser Leu Ser Pro 
    50                  55                  60                  


Ala Pro Arg Ser Gly Glu Leu Gly Leu Pro Gly Ala Pro Glu Ser Ser 
65                  70                  75                  80  


Thr Ala Ser Ala Pro Gly Glu Pro Ser Pro Pro Ser Pro Pro Cys Arg 
                85                  90                  95      


Arg Pro Gly Pro Asp Cys Arg Ala Lys Ser Arg Gly Arg His Gly Leu 
            100                 105                 110         


Gly Ala Gly Leu Gly Gly Pro Gly Ala Arg Leu Phe Gly Trp Leu Lys 
        115                 120                 125             


Glu Arg Ser Leu Gly Arg Gly Leu Phe Val Asp Pro Ala Arg Asp Asn 
    130                 135                 140                 


Phe Arg Thr Met Thr Ser Leu Tyr Gly Ser Ile His Pro Ala Asp Ser 
145                 150                 155                 160 


Val Tyr Leu Ser Thr Arg Thr His Gly Ala Val Phe Asn Leu Glu Tyr 
                165                 170                 175     


Ser Pro Asp Gly Ser Val Leu Thr Val Ala Cys Glu Gln Thr Glu Val 
            180                 185                 190         


Leu Leu Phe Asp Pro Ile Ser Ser Lys His Ile Lys Thr Leu Ser Glu 
        195                 200                 205             


Ala His Glu Asp Cys Val Asn Asn Ile Arg Phe Leu Asp Asn Arg Leu 
    210                 215                 220                 


Phe Ala Thr Cys Ser Asp Asp Thr Thr Ile Ala Leu Trp Asp Leu Arg 
225                 230                 235                 240 


Lys Leu Asn Thr Lys Val Cys Thr Leu His Gly His Thr Ser Trp Val 
                245                 250                 255     


Lys Asn Ile Glu Tyr Asp Thr Asn Thr Arg Leu Leu Val Thr Ser Gly 
            260                 265                 270         


Phe Asp Gly Asn Val Ile Ile Trp Asp Thr Asn Arg Tyr Thr Glu Asp 
        275                 280                 285             


Gly Cys Pro His Lys Lys Phe Phe His Thr Arg Phe Leu Met Arg Met 
    290                 295                 300                 


Arg Leu Thr Pro Asp Cys Ser Lys Met Leu Ile Ser Thr Ser Ser Gly 
305                 310                 315                 320 


Tyr Leu Leu Ile Leu His Asp Leu Asp Leu Thr Lys Ser Leu Glu Val 
                325                 330                 335     


Gly Ser Tyr Pro Ile Leu Arg Ala Arg Arg Thr Thr Ser Ser Ser Asp 
            340                 345                 350         


Leu Thr Thr Ser Ser Ser Ser Ser Gly Pro Arg Val Ser Gly Ser Pro 
        355                 360                 365             


Cys His His Ser Asp Ser Asn Ser Ser Glu Lys His Met Ser Arg Ala 
    370                 375                 380                 


Ser Gln Arg Glu Gly Val Ser Pro Arg Asn Ser Leu Glu Val Val Thr 
385                 390                 395                 400 


Pro Glu Val Leu Gly Glu Ser Asp His Gly Asn Cys Ile Thr Ser Leu 
                405                 410                 415     


Gln Leu His Pro Lys Gly Trp Ala Thr Leu Leu Arg Cys Ser Ser Asn 
            420                 425                 430         


Ser Asp Asp Glu Glu Cys Thr Cys Val Tyr Glu Phe Gln Glu Gly Ala 
        435                 440                 445             


Pro Val Arg Pro Val Ser Pro Arg Cys Ser Leu Arg Leu Thr His Tyr 
    450                 455                 460                 


Ile Glu Glu Ala Asn Val Gly Arg Gly Tyr Ile Lys Glu Leu Cys Phe 
465                 470                 475                 480 


Ser Pro Asp Gly Arg Met Ile Ser Ser Pro His Gly Tyr Gly Ile Arg 
                485                 490                 495     


Leu Leu Gly Phe Asp Lys Gln Cys Ser Glu Leu Val Asp Cys Leu Pro 
            500                 505                 510         


Lys Glu Ala Ser Pro Leu Arg Val Ile Arg Ser Leu Tyr Ser His Asn 
        515                 520                 525             


Asp Val Val Leu Thr Thr Lys Phe Ser Pro Thr His Cys Gln Ile Ala 
    530                 535                 540                 


Ser Gly Cys Leu Ser Gly Arg Val Ser Leu Tyr Gln Pro Lys Phe 
545                 550                 555                 


<210>  14
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Leu Ser Arg Ser His Arg Ser Val Leu Thr Val Ala Cys Glu Gln 
1               5                   10                  15      


Thr Glu Val Leu Leu Phe Asp Pro Ile Ser Ser Lys His Ile Lys Thr 
            20                  25                  30          


Leu Ser Glu Ala His Glu Asp Cys Val Asn Asn Ile Arg Phe Leu Asp 
        35                  40                  45              


Asn Arg Leu Phe Ala Thr Cys Ser Asp Asp Thr Thr Ile Ala Leu Trp 
    50                  55                  60                  


Asp Leu Arg Lys Leu Asn Thr Lys Val Cys Thr Leu His Gly His Thr 
65                  70                  75                  80  


Ser Trp Val Lys Asn Ile Glu Tyr Asp Thr Asn Thr Arg Leu Leu Val 
                85                  90                  95      


Thr Ser Gly Phe Asp Gly Asn Val Ile Ile Trp Asp Thr Asn Arg Tyr 
            100                 105                 110         


Thr Glu Asp Gly Cys Pro His Lys Lys Phe Phe His Thr Arg Phe Leu 
        115                 120                 125             


Met Arg Met Arg Leu Thr Pro Asp Cys Ser Lys Met Leu Ile Ser Thr 
    130                 135                 140                 


Ser Ser Gly Tyr Leu Leu Ile Leu His Asp Leu Asp Leu Thr Lys Ser 
145                 150                 155                 160 


Leu Glu Val Gly Ser Tyr Pro Ile Leu Arg Ala Arg Arg Thr Thr Ser 
                165                 170                 175     


Ser Ser Asp Leu Thr Thr Ser Ser Ser Ser Ser Gly Pro Arg Val Ser 
            180                 185                 190         


Gly Ser Pro Cys His His Ser Asp Ser Asn Ser Ser Glu Lys His Met 
        195                 200                 205             


Ser Arg Ala Ser Gln Arg Glu Gly Val Ser Pro Arg Asn Ser Leu Glu 
    210                 215                 220                 


Val Val Thr Pro Glu Val Leu Gly Glu Ser Asp His Gly Asn Cys Ile 
225                 230                 235                 240 


Thr Ser Leu Gln Leu His Pro Lys Gly Trp Ala Thr Leu Leu Arg Cys 
                245                 250                 255     


Ser Ser Asn Ser Asp Asp Glu Glu Cys Thr Cys Val Tyr Glu Phe Gln 
            260                 265                 270         


Glu Gly Ala Pro Val Arg Pro Val Ser Pro Arg Cys Ser Leu Arg Leu 
        275                 280                 285             


Thr His Tyr Ile Glu Glu Ala Asn Val Gly Arg Gly Tyr Ile Lys Glu 
    290                 295                 300                 


Leu Cys Phe Ser Pro Asp Gly Arg Met Ile Ser Ser Pro His Gly Tyr 
305                 310                 315                 320 


Gly Ile Arg Leu Leu Gly Phe Asp Lys Gln Cys Ser Glu Leu Val Asp 
                325                 330                 335     


Cys Leu Pro Lys Glu Ala Ser Pro Leu Arg Val Ile Arg Ser Leu Tyr 
            340                 345                 350         


Ser His Asn Asp Val Val Leu Thr Thr Lys Phe Ser Pro Thr His Cys 
        355                 360                 365             


Gln Ile Ala Ser Gly Cys Leu Ser Gly Arg Val Ser Leu Tyr Gln Pro 
    370                 375                 380                 


Lys Phe 
385     


<210>  15
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Ala Ala Met Asp Val Asp Thr Pro Ser Gly Thr Asn Ser Gly 
1               5                   10                  15      


Ala Gly Lys Lys Arg Phe Glu Val Lys Lys Trp Asn Ala Val Ala Leu 
            20                  25                  30          


Trp Ala Trp Asp Ile Val Val Asp Asn Cys Ala Ile Cys Arg Asn His 
        35                  40                  45              


Ile Met Asp Leu Cys Ile Glu Cys Gln Ala Asn Gln Ala Ser Ala Thr 
    50                  55                  60                  


Ser Glu Glu Cys Thr Val Ala Trp Gly Val Cys Asn His Ala Phe His 
65                  70                  75                  80  


Phe His Cys Ile Ser Arg Trp Leu Lys Thr Arg Gln Val Cys Pro Leu 
                85                  90                  95      


Asp Asn Arg Glu Trp Glu Phe Gln Lys Tyr Gly His 
            100                 105             


<210>  16
<211>  768
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Asn Leu Ser Lys Gly Thr Gly Ser Arg Lys Asp Thr Lys Met 
1               5                   10                  15      


Arg Ile Arg Ala Phe Pro Met Thr Met Asp Glu Lys Tyr Val Asn Ser 
            20                  25                  30          


Ile Trp Asp Leu Leu Lys Asn Ala Ile Gln Glu Ile Gln Arg Lys Asn 
        35                  40                  45              


Asn Ser Gly Leu Ser Phe Glu Glu Leu Tyr Arg Asn Ala Tyr Thr Met 
    50                  55                  60                  


Val Leu His Lys His Gly Glu Lys Leu Tyr Thr Gly Leu Arg Glu Val 
65                  70                  75                  80  


Val Thr Glu His Leu Ile Asn Lys Val Arg Glu Asp Val Leu Asn Ser 
                85                  90                  95      


Leu Asn Asn Asn Phe Leu Gln Thr Leu Asn Gln Ala Trp Asn Asp His 
            100                 105                 110         


Gln Thr Ala Met Val Met Ile Arg Asp Ile Leu Met Tyr Met Asp Arg 
        115                 120                 125             


Val Tyr Val Gln Gln Asn Asn Val Glu Asn Val Tyr Asn Leu Gly Leu 
    130                 135                 140                 


Ile Ile Phe Arg Asp Gln Val Val Arg Tyr Gly Cys Ile Arg Asp His 
145                 150                 155                 160 


Leu Arg Gln Thr Leu Leu Asp Met Ile Ala Arg Glu Arg Lys Gly Glu 
                165                 170                 175     


Val Val Asp Arg Gly Ala Ile Arg Asn Ala Cys Gln Met Leu Met Ile 
            180                 185                 190         


Leu Gly Leu Glu Gly Arg Ser Val Tyr Glu Glu Asp Phe Glu Ala Pro 
        195                 200                 205             


Phe Leu Glu Met Ser Ala Glu Phe Phe Gln Met Glu Ser Gln Lys Phe 
    210                 215                 220                 


Leu Ala Glu Asn Ser Ala Ser Val Tyr Ile Lys Lys Val Glu Ala Arg 
225                 230                 235                 240 


Ile Asn Glu Glu Ile Glu Arg Val Met His Cys Leu Asp Lys Ser Thr 
                245                 250                 255     


Glu Glu Pro Ile Val Lys Val Val Glu Arg Glu Leu Ile Ser Lys His 
            260                 265                 270         


Met Lys Thr Ile Val Glu Met Glu Asn Ser Gly Leu Val His Met Leu 
        275                 280                 285             


Lys Asn Gly Lys Thr Glu Asp Leu Gly Cys Met Tyr Lys Leu Phe Ser 
    290                 295                 300                 


Arg Val Pro Asn Gly Leu Lys Thr Met Cys Glu Cys Met Ser Ser Tyr 
305                 310                 315                 320 


Leu Arg Glu Gln Gly Lys Ala Leu Val Ser Glu Glu Gly Glu Gly Lys 
                325                 330                 335     


Asn Pro Val Asp Tyr Ile Gln Gly Leu Leu Asp Leu Lys Ser Arg Phe 
            340                 345                 350         


Asp Arg Phe Leu Leu Glu Ser Phe Asn Asn Asp Arg Leu Phe Lys Gln 
        355                 360                 365             


Thr Ile Ala Gly Asp Phe Glu Tyr Phe Leu Asn Leu Asn Ser Arg Ser 
    370                 375                 380                 


Pro Glu Tyr Leu Ser Leu Phe Ile Asp Asp Lys Leu Lys Lys Gly Val 
385                 390                 395                 400 


Lys Gly Leu Thr Glu Gln Glu Val Glu Thr Ile Leu Asp Lys Ala Met 
                405                 410                 415     


Val Leu Phe Arg Phe Met Gln Glu Lys Asp Val Phe Glu Arg Tyr Tyr 
            420                 425                 430         


Lys Gln His Leu Ala Arg Arg Leu Leu Thr Asn Lys Ser Val Ser Asp 
        435                 440                 445             


Asp Ser Glu Lys Asn Met Ile Ser Lys Leu Lys Thr Glu Cys Gly Cys 
    450                 455                 460                 


Gln Phe Thr Ser Lys Leu Glu Gly Met Phe Arg Asp Met Ser Ile Ser 
465                 470                 475                 480 


Asn Thr Thr Met Asp Glu Phe Arg Gln His Leu Gln Ala Thr Gly Val 
                485                 490                 495     


Ser Leu Gly Gly Val Asp Leu Thr Val Arg Val Leu Thr Thr Gly Tyr 
            500                 505                 510         


Trp Pro Thr Gln Ser Ala Thr Pro Lys Cys Asn Ile Pro Pro Ala Pro 
        515                 520                 525             


Arg His Ala Phe Glu Ile Phe Arg Arg Phe Tyr Leu Ala Lys His Ser 
    530                 535                 540                 


Gly Arg Gln Leu Thr Leu Gln His His Met Gly Ser Ala Asp Leu Asn 
545                 550                 555                 560 


Ala Thr Phe Tyr Gly Pro Val Lys Lys Glu Asp Gly Ser Glu Val Gly 
                565                 570                 575     


Val Gly Gly Ala Gln Val Thr Gly Ser Asn Thr Arg Lys His Ile Leu 
            580                 585                 590         


Gln Val Ser Thr Phe Gln Met Thr Ile Leu Met Leu Phe Asn Asn Arg 
        595                 600                 605             


Glu Lys Tyr Thr Phe Glu Glu Ile Gln Gln Glu Thr Asp Ile Pro Glu 
    610                 615                 620                 


Arg Glu Leu Val Arg Ala Leu Gln Ser Leu Ala Cys Gly Lys Pro Thr 
625                 630                 635                 640 


Gln Arg Val Leu Thr Lys Glu Pro Lys Ser Lys Glu Ile Glu Asn Gly 
                645                 650                 655     


His Ile Phe Thr Val Asn Asp Gln Phe Thr Ser Lys Leu His Arg Val 
            660                 665                 670         


Lys Ile Gln Thr Val Ala Ala Lys Gln Gly Glu Ser Asp Pro Glu Arg 
        675                 680                 685             


Lys Glu Thr Arg Gln Lys Val Asp Asp Asp Arg Lys His Glu Ile Glu 
    690                 695                 700                 


Ala Ala Ile Val Arg Ile Met Lys Ser Arg Lys Lys Met Gln His Asn 
705                 710                 715                 720 


Val Leu Val Ala Glu Val Thr Gln Gln Leu Lys Ala Arg Phe Leu Pro 
                725                 730                 735     


Ser Pro Val Val Ile Lys Lys Arg Ile Glu Gly Leu Ile Glu Arg Glu 
            740                 745                 750         


Tyr Leu Ala Arg Thr Pro Glu Asp Arg Lys Val Tyr Thr Tyr Val Ala 
        755                 760                 765             


<210>  17
<211>  897
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asn Ile Ser Gly Ser Ser Cys Gly Ser Pro Asn Ser Ala Asp Thr 
1               5                   10                  15      


Ser Ser Asp Phe Lys Asp Leu Trp Thr Lys Leu Lys Glu Cys His Asp 
            20                  25                  30          


Arg Glu Val Gln Gly Leu Gln Val Lys Val Thr Lys Leu Lys Gln Glu 
        35                  40                  45              


Arg Ile Leu Asp Ala Gln Arg Leu Glu Glu Phe Phe Thr Lys Asn Gln 
    50                  55                  60                  


Gln Leu Arg Glu Gln Gln Lys Val Leu His Glu Thr Ile Lys Val Leu 
65                  70                  75                  80  


Glu Asp Arg Leu Arg Ala Gly Leu Cys Asp Arg Cys Ala Val Thr Glu 
                85                  90                  95      


Glu His Met Arg Lys Lys Gln Gln Glu Phe Glu Asn Ile Arg Gln Gln 
            100                 105                 110         


Asn Leu Lys Leu Ile Thr Glu Leu Met Asn Glu Arg Asn Thr Leu Gln 
        115                 120                 125             


Glu Glu Asn Lys Lys Leu Ser Glu Gln Leu Gln Gln Lys Ile Glu Asn 
    130                 135                 140                 


Asp Gln Gln His Gln Ala Ala Glu Leu Glu Cys Glu Glu Asp Val Ile 
145                 150                 155                 160 


Pro Asp Ser Pro Ile Thr Ala Phe Ser Phe Ser Gly Val Asn Arg Leu 
                165                 170                 175     


Arg Arg Lys Glu Asn Pro His Val Arg Tyr Ile Glu Gln Thr His Thr 
            180                 185                 190         


Lys Leu Glu His Ser Val Cys Ala Asn Glu Met Arg Lys Val Ser Lys 
        195                 200                 205             


Ser Ser Thr His Pro Gln His Asn Pro Asn Glu Asn Glu Ile Leu Val 
    210                 215                 220                 


Ala Asp Thr Tyr Asp Gln Ser Gln Ser Pro Met Ala Lys Ala His Gly 
225                 230                 235                 240 


Thr Ser Ser Tyr Thr Pro Asp Lys Ser Ser Phe Asn Leu Ala Thr Val 
                245                 250                 255     


Val Ala Glu Thr Leu Gly Leu Gly Val Gln Glu Glu Ser Glu Thr Gln 
            260                 265                 270         


Gly Pro Met Ser Pro Leu Gly Asp Glu Leu Tyr His Cys Leu Glu Gly 
        275                 280                 285             


Asn His Lys Lys Gln Pro Phe Glu Glu Ser Thr Arg Asn Thr Glu Asp 
    290                 295                 300                 


Ser Leu Arg Phe Ser Asp Ser Thr Ser Lys Thr Pro Pro Gln Glu Glu 
305                 310                 315                 320 


Leu Pro Thr Arg Val Ser Ser Pro Val Phe Gly Ala Thr Ser Ser Ile 
                325                 330                 335     


Lys Ser Gly Leu Asp Leu Asn Thr Ser Leu Ser Pro Ser Leu Leu Gln 
            340                 345                 350         


Pro Gly Lys Lys Lys His Leu Lys Thr Leu Pro Phe Ser Asn Thr Cys 
        355                 360                 365             


Ile Ser Arg Leu Glu Lys Thr Arg Ser Lys Ser Glu Asp Ser Ala Leu 
    370                 375                 380                 


Phe Thr His His Ser Leu Gly Ser Glu Val Asn Lys Ile Ile Ile Gln 
385                 390                 395                 400 


Ser Ser Asn Lys Gln Ile Leu Ile Asn Lys Asn Ile Ser Glu Ser Leu 
                405                 410                 415     


Gly Glu Gln Asn Arg Thr Glu Tyr Gly Lys Asp Ser Asn Thr Asp Lys 
            420                 425                 430         


His Leu Glu Pro Leu Lys Ser Leu Gly Gly Arg Thr Ser Lys Arg Lys 
        435                 440                 445             


Lys Thr Glu Glu Glu Ser Glu His Glu Val Ser Cys Pro Gln Ala Ser 
    450                 455                 460                 


Phe Asp Lys Glu Asn Ala Phe Pro Phe Pro Met Asp Asn Gln Phe Ser 
465                 470                 475                 480 


Met Asn Gly Asp Cys Val Met Asp Lys Pro Leu Asp Leu Ser Asp Arg 
                485                 490                 495     


Phe Ser Ala Ile Gln Arg Gln Glu Lys Ser Gln Gly Ser Glu Thr Ser 
            500                 505                 510         


Lys Asn Lys Phe Arg Gln Val Thr Leu Tyr Glu Ala Leu Lys Thr Ile 
        515                 520                 525             


Pro Lys Gly Phe Ser Ser Ser Arg Lys Ala Ser Asp Gly Asn Cys Thr 
    530                 535                 540                 


Leu Pro Lys Asp Ser Pro Gly Glu Pro Cys Ser Gln Glu Cys Ile Ile 
545                 550                 555                 560 


Leu Gln Pro Leu Asn Lys Cys Ser Pro Asp Asn Lys Pro Ser Leu Gln 
                565                 570                 575     


Ile Lys Glu Glu Asn Ala Val Phe Lys Ile Pro Leu Arg Pro Arg Glu 
            580                 585                 590         


Ser Leu Glu Thr Glu Asn Val Leu Asp Asp Ile Lys Ser Ala Gly Ser 
        595                 600                 605             


His Glu Pro Ile Lys Ile Gln Thr Arg Ser Asp His Gly Gly Cys Glu 
    610                 615                 620                 


Leu Ala Ser Val Leu Gln Leu Asn Pro Cys Arg Thr Gly Lys Ile Lys 
625                 630                 635                 640 


Ser Leu Gln Asn Asn Gln Asp Val Ser Phe Glu Asn Ile Gln Trp Ser 
                645                 650                 655     


Ile Asp Pro Gly Ala Asp Leu Ser Gln Tyr Lys Met Asp Val Thr Val 
            660                 665                 670         


Ile Asp Thr Lys Asp Gly Ser Gln Ser Lys Leu Gly Gly Glu Thr Val 
        675                 680                 685             


Asp Met Asp Cys Thr Leu Val Ser Glu Thr Val Leu Leu Lys Met Lys 
    690                 695                 700                 


Lys Gln Glu Gln Lys Gly Glu Lys Ser Ser Asn Glu Glu Arg Lys Met 
705                 710                 715                 720 


Asn Asp Ser Leu Glu Asp Met Phe Asp Arg Thr Thr His Glu Glu Tyr 
                725                 730                 735     


Glu Ser Cys Leu Ala Asp Ser Phe Ser Gln Ala Ala Asp Glu Glu Glu 
            740                 745                 750         


Glu Leu Ser Thr Ala Thr Lys Lys Leu His Thr His Gly Asp Lys Gln 
        755                 760                 765             


Asp Lys Val Lys Gln Lys Ala Phe Val Glu Pro Tyr Phe Lys Gly Asp 
    770                 775                 780                 


Glu Arg Glu Thr Ser Leu Gln Asn Phe Pro His Ile Glu Val Val Arg 
785                 790                 795                 800 


Lys Lys Glu Glu Arg Arg Lys Leu Leu Gly His Thr Cys Lys Glu Cys 
                805                 810                 815     


Glu Ile Tyr Tyr Ala Asp Met Pro Ala Glu Glu Arg Glu Lys Lys Leu 
            820                 825                 830         


Ala Ser Cys Ser Arg His Arg Phe Arg Tyr Ile Pro Pro Asn Thr Pro 
        835                 840                 845             


Glu Asn Phe Trp Glu Val Gly Phe Pro Ser Thr Gln Thr Cys Met Glu 
    850                 855                 860                 


Arg Gly Tyr Ile Lys Glu Asp Leu Asp Pro Cys Pro Arg Pro Lys Arg 
865                 870                 875                 880 


Arg Gln Pro Tyr Asn Ala Ile Phe Ser Pro Lys Gly Lys Glu Gln Lys 
                885                 890                 895     


Thr 
    


