                         SEQUENCE LISTING

<110>  CITY OF HOPE
       KALKUM, Markus
       BAGRAMYAN, Karine
       YAZAKI, Paul
 
<120>  SINGLE CHAIN ANTIBODY DOMAINS FOR DETECTION OF ANTI-BOTULINUM 
       NEUROTOXIN DOMAINS AND METHODS OF THEIR USE

<130>  48440-563001WO

<140>  PCT/US2016/020094
<141>  2016-02-29

<150>  62/121,642
<151>  2015-02-27

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Gly Thr Trp Phe Arg 
            20                  25                  30          


Phe Asp Glu Asn Thr Val Asn Trp Tyr Arg Gln Pro Pro Gly Lys Ser 
        35                  40                  45              


Arg Glu Phe Asp Glu Leu Val Ala Arg Tyr Pro Lys Ser Gly Ile Val 
    50                  55                  60                  


Thr Tyr Leu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
65                  70                  75                  80  


Ala Lys Lys Met Ala Phe Leu Gln Met Asp Asn Leu Lys Pro Glu Asp 
                85                  90                  95      


Thr Ala Val Tyr Tyr Cys Asn Val Gly Glu Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Ile Ser Ser Glu Pro Lys Thr Pro Lys Pro 
        115                 120                 125 


<210>  2
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Asp Ile Ser Gly Ile 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Met Val 
        35                  40                  45              


Ala Asp Ile Phe Ser Gly Gly Ser Thr Asp Tyr Ala Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Ser Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Val Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys Arg 
                85                  90                  95      


Leu Tyr Gly Ser Gly Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Ala His His Ser Glu Asp 
        115                 120 


<210>  3
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ser Gly Ile Ser Gly Ile 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Met Val 
        35                  40                  45              


Ala Asp Ile Phe Ser Gly Gly Ser Thr Asp Tyr Ala Gly Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Ser Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Ala Lys Pro Glu Asp Thr Gly Ala Tyr Tyr Cys Arg 
                85                  90                  95      


Leu Tyr Gly Ser Gly Asp Tyr Trp Val Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser Ala His His Ser Glu Asp 
        115                 120 


<210>  4
<211>  1960
<212>  PRT
<213>  Nucleic acid

<400>  4

Gly Ala Gly Ala Thr Ala Thr Ala Cys Cys Ala Thr Gly Gly Ala Ala 
1               5                   10                  15      


Ala Ala Gly Ala Ala Gly Ala Ala Gly Ala Ala Gly Ala Ala Gly Ala 
            20                  25                  30          


Ala Ala Ala Ala Gly Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly Gly 
        35                  40                  45              


Thr Gly Gly Cys Ala Gly Cys Gly Gly Thr Gly Gly Cys Ala Thr Gly 
    50                  55                  60                  


Ala Gly Cys Gly Ala Thr Ala Ala Ala Ala Thr Cys Ala Thr Thr Cys 
65                  70                  75                  80  


Ala Thr Cys Thr Gly Ala Cys Cys Gly Ala Thr Gly Ala Thr Ala Gly 
                85                  90                  95      


Cys Thr Thr Cys Gly Ala Thr Ala Cys Cys Gly Ala Thr Gly Thr Thr 
            100                 105                 110         


Cys Thr Gly Ala Ala Ala Gly Cys Ala Gly Ala Thr Gly Gly Thr Gly 
        115                 120                 125             


Cys Ala Ala Thr Thr Cys Thr Gly Gly Thr Thr Gly Ala Thr Thr Thr 
    130                 135                 140                 


Thr Thr Gly Gly Gly Cys Ala Gly Ala Ala Thr Gly Gly Thr Gly Thr 
145                 150                 155                 160 


Gly Gly Thr Cys Cys Gly Thr Gly Thr Ala Ala Ala Ala Thr Gly Ala 
                165                 170                 175     


Thr Thr Gly Cys Ala Cys Cys Gly Ala Thr Thr Cys Thr Gly Gly Ala 
            180                 185                 190         


Thr Gly Ala Ala Ala Thr Cys Gly Cys Cys Gly Ala Thr Gly Ala Ala 
        195                 200                 205             


Thr Ala Thr Cys Ala Gly Gly Gly Thr Ala Ala Ala Cys Thr Gly Ala 
    210                 215                 220                 


Cys Cys Gly Thr Thr Gly Cys Ala Ala Ala Ala Cys Thr Gly Ala Ala 
225                 230                 235                 240 


Cys Ala Thr Thr Gly Ala Thr Cys Ala Gly Ala Ala Thr Cys Cys Gly 
                245                 250                 255     


Gly Gly Thr Ala Cys Ala Gly Cys Ala Cys Cys Gly Ala Ala Ala Thr 
            260                 265                 270         


Ala Thr Gly Gly Thr Ala Thr Thr Cys Gly Thr Gly Gly Thr Ala Thr 
        275                 280                 285             


Thr Cys Cys Gly Ala Cys Cys Cys Thr Gly Cys Thr Gly Cys Thr Gly 
    290                 295                 300                 


Thr Thr Thr Ala Ala Ala Ala Ala Cys Gly Gly Thr Gly Ala Ala Gly 
305                 310                 315                 320 


Thr Thr Gly Cys Ala Gly Cys Ala Ala Cys Cys Ala Ala Ala Gly Thr 
                325                 330                 335     


Thr Gly Gly Thr Gly Cys Ala Cys Thr Gly Ala Gly Cys Ala Ala Ala 
            340                 345                 350         


Gly Gly Thr Cys Ala Gly Cys Thr Gly Ala Ala Ala Gly Ala Ala Thr 
        355                 360                 365             


Thr Thr Cys Thr Gly Gly Ala Thr Gly Cys Ala Ala Ala Thr Cys Thr 
    370                 375                 380                 


Gly Gly Cys Ala Gly Gly Thr Ala Gly Cys Gly Gly Thr Ala Gly Cys 
385                 390                 395                 400 


Gly Gly Thr Cys Ala Thr Ala Thr Gly Cys Ala Thr Cys Ala Thr Cys 
                405                 410                 415     


Ala Thr Cys Ala Thr Cys Ala Cys Cys Ala Thr Ala Gly Cys Ala Gly 
            420                 425                 430         


Cys Gly Gly Thr Cys Thr Gly Gly Thr Thr Cys Cys Gly Cys Gly Thr 
        435                 440                 445             


Gly Gly Thr Ala Gly Cys Gly Gly Thr Ala Thr Gly Ala Ala Ala Gly 
    450                 455                 460                 


Ala Ala Ala Cys Cys Gly Cys Ala Gly Cys Ala Gly Cys Ala Ala Ala 
465                 470                 475                 480 


Ala Thr Thr Thr Gly Ala Ala Cys Gly Thr Cys Ala Gly Cys Ala Cys 
                485                 490                 495     


Ala Thr Gly Gly Ala Thr Ala Gly Thr Cys Cys Ala Gly Ala Thr Cys 
            500                 505                 510         


Thr Gly Gly Gly Cys Ala Cys Cys Gly Ala Thr Gly Ala Thr Gly Ala 
        515                 520                 525             


Thr Gly Ala Cys Ala Ala Ala Gly Cys Ala Ala Thr Gly Gly Cys Ala 
    530                 535                 540                 


Ala Thr Thr Ala Gly Cys Gly Ala Thr Cys Cys Gly Ala Ala Thr Ala 
545                 550                 555                 560 


Gly Cys Gly Gly Thr Gly Cys Thr Cys Cys Gly Gly Thr Thr Cys Cys 
                565                 570                 575     


Gly Thr Ala Thr Cys Cys Thr Gly Ala Thr Cys Cys Gly Cys Thr Gly 
            580                 585                 590         


Gly Ala Ala Cys Cys Gly Cys Gly Thr Gly Cys Ala Gly Cys Ala Gly 
        595                 600                 605             


Cys Ala Cys Ala Gly Gly Thr Thr Cys Ala Gly Cys Thr Gly Gly Thr 
    610                 615                 620                 


Thr Gly Ala Ala Ala Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Thr 
625                 630                 635                 640 


Cys Thr Gly Gly Thr Thr Cys Ala Gly Gly Thr Thr Gly Gly Thr Gly 
                645                 650                 655     


Gly Thr Ala Gly Cys Cys Thr Gly Cys Gly Thr Cys Thr Gly Ala Gly 
            660                 665                 670         


Cys Thr Gly Thr Gly Thr Thr Gly Thr Thr Ala Gly Cys Gly Gly Thr 
        675                 680                 685             


Ala Gly Thr Gly Gly Thr Ala Thr Thr Ala Gly Cys Gly Gly Thr Ala 
    690                 695                 700                 


Thr Thr Gly Cys Ala Ala Thr Gly Gly Gly Thr Thr Gly Gly Thr Ala 
705                 710                 715                 720 


Thr Cys Gly Thr Cys Ala Gly Gly Cys Ala Cys Cys Gly Gly Gly Thr 
                725                 730                 735     


Ala Ala Ala Cys Gly Thr Cys Gly Thr Gly Ala Ala Ala Thr Gly Gly 
            740                 745                 750         


Thr Thr Gly Cys Ala Gly Ala Thr Ala Thr Cys Thr Thr Thr Ala Gly 
        755                 760                 765             


Cys Gly Gly Thr Gly Gly Thr Ala Gly Cys Ala Cys Ala Gly Ala Thr 
    770                 775                 780                 


Thr Ala Thr Gly Cys Ala Gly Gly Thr Ala Gly Cys Gly Thr Thr Ala 
785                 790                 795                 800 


Ala Ala Gly Gly Thr Cys Gly Thr Thr Thr Thr Ala Cys Cys Ala Thr 
                805                 810                 815     


Thr Ala Gly Cys Cys Gly Thr Gly Ala Thr Ala Ala Cys Gly Cys Ala 
            820                 825                 830         


Ala Ala Ala Ala Ala Ala Ala Cys Cys Ala Gly Cys Thr Ala Thr Cys 
        835                 840                 845             


Thr Gly Cys Ala Gly Ala Thr Gly Ala Ala Thr Ala Ala Thr Gly Cys 
    850                 855                 860                 


Cys Ala Ala Ala Cys Cys Gly Gly Ala Ala Gly Ala Thr Ala Cys Cys 
865                 870                 875                 880 


Gly Gly Thr Gly Cys Ala Thr Ala Thr Thr Ala Thr Thr Gly Thr Cys 
                885                 890                 895     


Gly Thr Cys Thr Gly Thr Ala Thr Gly Gly Thr Ala Gly Thr Gly Gly 
            900                 905                 910         


Cys Gly Ala Thr Thr Ala Thr Thr Gly Gly Gly Thr Thr Cys Ala Gly 
        915                 920                 925             


Gly Gly Cys Ala Cys Cys Cys Ala Gly Gly Thr Thr Ala Cys Cys Gly 
    930                 935                 940                 


Thr Thr Ala Gly Cys Ala Gly Cys Gly Cys Ala Cys Ala Thr Cys Ala 
945                 950                 955                 960 


Thr Ala Gly Cys Gly Ala Ala Gly Ala Thr Cys Cys Gly Ala Cys Cys 
                965                 970                 975     


Ala Gly Cys Gly Cys Gly Ala Thr Cys Gly Cys Thr Gly Gly Cys Gly 
            980                 985                 990         


Gly Thr Gly Gly Thr Gly Gly Thr  Thr Cys Cys Gly Gly  Thr Gly Gly 
        995                 1000                 1005             


Thr Gly  Gly Cys Gly Gly Thr  Ala Gly Thr Gly Gly  Thr Gly Gly 
    1010                 1015                 1020             


Thr Gly  Gly Thr Gly Gly Cys  Thr Cys Ala Gly Gly  Gly Gly Cys 
    1025                 1030                 1035             


Cys Cys  Cys Ala Gly Thr Thr  Cys Cys Gly Thr Ala  Thr Cys Cys 
    1040                 1045                 1050             


Gly Gly  Ala Cys Cys Cys Thr  Thr Thr Ala Gly Ala  Ala Cys Cys 
    1055                 1060                 1065             


Thr Cys  Gly Cys Gly Cys Thr  Gly Cys Ala Gly Cys  Cys Cys Ala 
    1070                 1075                 1080             


Gly Gly  Thr Gly Cys Ala Ala  Cys Thr Gly Gly Thr  Gly Gly Ala 
    1085                 1090                 1095             


Ala Thr  Cys Thr Gly Gly Thr  Gly Gly Thr Gly Gly  Cys Cys Thr 
    1100                 1105                 1110             


Gly Gly  Thr Gly Cys Ala Ala  Gly Thr Gly Gly Gly  Thr Gly Gly 
    1115                 1120                 1125             


Thr Thr  Cys Ala Cys Thr Gly  Cys Gly Thr Cys Thr  Gly Thr Cys 
    1130                 1135                 1140             


Ala Thr  Gly Thr Gly Thr Thr  Gly Thr Thr Thr Cys  Ala Gly Gly 
    1145                 1150                 1155             


Thr Thr  Cys Ala Gly Gly Thr  Ala Thr Thr Thr Cys  Ala Gly Gly 
    1160                 1165                 1170             


Cys Ala  Thr Ala Gly Cys Thr  Ala Thr Gly Gly Gly  Cys Thr Gly 
    1175                 1180                 1185             


Gly Thr  Ala Thr Cys Gly Cys  Cys Ala Ala Gly Cys  Cys Cys Cys 
    1190                 1195                 1200             


Thr Gly  Gly Cys Ala Ala Ala  Cys Gly Thr Cys Gly  Cys Gly Ala 
    1205                 1210                 1215             


Gly Ala  Thr Gly Gly Thr Gly  Gly Cys Cys Gly Ala  Thr Ala Thr 
    1220                 1225                 1230             


Thr Thr  Thr Cys Ala Gly Thr  Gly Gly Thr Gly Gly  Thr Thr Cys 
    1235                 1240                 1245             


Ala Ala  Cys Cys Gly Ala Thr  Thr Ala Thr Gly Cys  Cys Gly Gly 
    1250                 1255                 1260             


Thr Thr  Cys Ala Gly Thr Gly  Ala Ala Ala Gly Gly  Thr Cys Gly 
    1265                 1270                 1275             


Cys Thr  Thr Thr Ala Cys Ala  Ala Thr Thr Thr Cys  Ala Cys Gly 
    1280                 1285                 1290             


Thr Gly  Ala Cys Ala Ala Thr  Gly Cys Cys Ala Ala  Ala Ala Ala 
    1295                 1300                 1305             


Ala Ala  Ala Cys Cys Thr Cys  Ala Thr Ala Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Ala Gly  Ala Thr Gly Ala Ala  Cys Ala Ala Cys Gly  Cys Ala Ala 
    1325                 1330                 1335             


Ala Ala  Cys Cys Thr Gly Ala  Gly Gly Ala Cys Ala  Cys Ala Gly 
    1340                 1345                 1350             


Gly Thr  Gly Cys Cys Thr Ala  Thr Thr Ala Cys Thr  Gly Cys Cys 
    1355                 1360                 1365             


Gly Thr  Cys Thr Gly Thr Ala  Cys Gly Gly Thr Thr  Cys Ala Gly 
    1370                 1375                 1380             


Gly Thr  Gly Ala Thr Thr Ala  Thr Thr Gly Gly Gly  Thr Gly Cys 
    1385                 1390                 1395             


Ala Ala  Gly Gly Thr Ala Cys  Thr Cys Ala Gly Gly  Thr Gly Ala 
    1400                 1405                 1410             


Cys Ala  Gly Thr Thr Ala Gly  Cys Thr Cys Ala Gly  Ala Cys Ala 
    1415                 1420                 1425             


Thr Cys  Ala Thr Thr Cys Ala  Gly Ala Ala Gly Ala  Thr Cys Cys 
    1430                 1435                 1440             


Thr Ala  Cys Cys Thr Cys Ala  Gly Cys Ala Ala Thr  Thr Gly Cys 
    1445                 1450                 1455             


Cys Gly  Gly Thr Gly Gly Thr  Gly Gly Cys Gly Gly  Ala Thr Cys 
    1460                 1465                 1470             


Cys Gly  Gly Thr Gly Gly Cys  Gly Gly Thr Gly Gly  Thr Thr Cys 
    1475                 1480                 1485             


Thr Gly  Gly Cys Gly Gly Thr  Gly Gly Thr Gly Gly  Thr Thr Cys 
    1490                 1495                 1500             


Ala Cys  Ala Ala Gly Thr Gly  Cys Ala Gly Cys Thr  Gly Gly Thr 
    1505                 1510                 1515             


Ala Gly  Ala Ala Thr Cys Thr  Gly Gly Thr Gly Gly  Cys Gly Gly 
    1520                 1525                 1530             


Thr Cys  Thr Gly Gly Cys Ala  Cys Ala Gly Cys Cys  Thr Gly Gly 
    1535                 1540                 1545             


Thr Gly  Gly Thr Thr Cys Thr  Cys Thr Gly Cys Gly  Cys Cys Thr 
    1550                 1555                 1560             


Gly Ala  Gly Cys Thr Gly Cys  Gly Ala Ala Gly Cys  Ala Ala Gly 
    1565                 1570                 1575             


Cys Gly  Gly Thr Thr Thr Thr  Gly Gly Cys Ala Cys  Cys Thr Gly 
    1580                 1585                 1590             


Gly Thr  Thr Thr Cys Gly Thr  Thr Thr Thr Gly Ala  Thr Gly Ala 
    1595                 1600                 1605             


Ala Ala  Ala Cys Ala Cys Cys  Gly Thr Thr Ala Ala  Cys Thr Gly 
    1610                 1615                 1620             


Gly Thr  Ala Thr Cys Gly Thr  Cys Ala Ala Cys Cys  Gly Cys Cys 
    1625                 1630                 1635             


Thr Gly  Gly Thr Ala Ala Ala  Ala Gly Cys Cys Gly  Thr Gly Ala 
    1640                 1645                 1650             


Ala Thr  Thr Thr Gly Ala Thr  Gly Ala Ala Cys Thr  Gly Gly Thr 
    1655                 1660                 1665             


Thr Gly  Cys Ala Cys Gly Thr  Thr Ala Thr Cys Cys  Gly Ala Ala 
    1670                 1675                 1680             


Ala Ala  Gly Cys Gly Gly Thr  Ala Thr Thr Gly Thr  Thr Ala Cys 
    1685                 1690                 1695             


Cys Thr  Ala Thr Cys Thr Gly  Gly Ala Thr Ala Gly  Thr Gly Thr 
    1700                 1705                 1710             


Gly Ala  Ala Ala Gly Gly Cys  Cys Gly Thr Thr Thr  Cys Ala Cys 
    1715                 1720                 1725             


Cys Ala  Thr Thr Thr Cys Thr  Cys Gly Cys Gly Ala  Thr Ala Ala 
    1730                 1735                 1740             


Thr Gly  Cys Gly Ala Ala Ala  Ala Ala Ala Ala Thr  Gly Gly Cys 
    1745                 1750                 1755             


Ala Thr  Thr Cys Cys Thr Gly  Cys Ala Gly Ala Thr  Gly Gly Ala 
    1760                 1765                 1770             


Thr Ala  Ala Cys Cys Thr Gly  Ala Ala Ala Cys Cys  Thr Gly Ala 
    1775                 1780                 1785             


Ala Gly  Ala Thr Ala Cys Ala  Gly Cys Cys Gly Thr  Gly Thr Ala 
    1790                 1795                 1800             


Thr Thr  Ala Thr Thr Gly Cys  Ala Ala Thr Gly Thr  Thr Gly Gly 
    1805                 1810                 1815             


Thr Gly  Ala Ala Thr Thr Thr  Thr Thr Gly Gly Gly  Gly Thr Cys 
    1820                 1825                 1830             


Ala Gly  Gly Gly Thr Ala Cys  Thr Cys Ala Gly Gly  Thr Ala Ala 
    1835                 1840                 1845             


Cys Cys  Ala Thr Thr Ala Gly  Thr Ala Gly Cys Gly  Ala Ala Cys 
    1850                 1855                 1860             


Cys Gly  Ala Ala Ala Ala Cys  Cys Cys Cys Gly Ala  Ala Ala Cys 
    1865                 1870                 1875             


Cys Gly  Cys Ala Gly Ala Cys  Cys Ala Gly Thr Gly  Gly Thr Gly 
    1880                 1885                 1890             


Cys Thr  Cys Cys Gly Gly Thr  Gly Cys Cys Thr Thr  Ala Thr Cys 
    1895                 1900                 1905             


Cys Ala  Gly Ala Cys Cys Cys  Ala Cys Thr Gly Gly  Ala Ala Cys 
    1910                 1915                 1920             


Cys Ala  Cys Gly Thr Cys Thr  Cys Gly Ala Gly Ala  Cys Cys Ala 
    1925                 1930                 1935             


Cys Cys  Ala Cys Cys Ala Cys  Cys Ala Cys Cys Ala  Cys Thr Gly 
    1940                 1945                 1950             


Ala Gly  Ala Thr Cys Cys Gly  
    1955                 1960 


<210>  5
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  5

Gly Ser Gly Ile Ser Gly Ile Ala 
1               5               


<210>  6
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  6

Ile Phe Ser Gly Gly Ser Thr 
1               5           


<210>  7
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  7

Arg Leu Tyr Gly Ser Gly Asp Tyr Trp Val Gln 
1               5                   10      


<210>  8
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Val Ser 
            20                  25  


<210>  9
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  9

Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Arg Arg Glu Met Val Ala 
1               5                   10                  15      


Asp 
    


<210>  10
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  10

Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys 
1               5                   10                  15      


Thr Ser Tyr Leu Gln Met Asn Asn Ala Lys Pro Glu Asp Thr Gly Ala 
            20                  25                  30          


Tyr Tyr Cys 
        35  


<210>  11
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  11

Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser Glu Asp 
1               5                   10                  


<210>  12
<211>  73
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  12

Glu Glu Glu Glu Lys Lys Lys Gln Gln Glu Glu Glu Ala Glu Arg Leu 
1               5                   10                  15      


Arg Arg Ile Gln Glu Glu Met Glu Lys Glu Arg Lys Arg Arg Glu Glu 
            20                  25                  30          


Asp Glu Glu Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Met Lys Leu 
        35                  40                  45              


Glu Met Glu Ala Lys Arg Lys Gln Glu Glu Glu Glu Arg Lys Lys Arg 
    50                  55                  60                  


Glu Asp Asp Glu Lys Arg Lys Lys Lys 
65                  70              


<210>  13
<211>  206
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  13

Glu Glu Glu Glu Lys Lys Lys Glu Glu Glu Glu Lys Lys Gln Lys Glu 
1               5                   10                  15      


Glu Gln Glu Arg Leu Ala Lys Glu Glu Ala Glu Arg Lys Gln Lys Glu 
            20                  25                  30          


Glu Gln Glu Arg Leu Ala Lys Glu Glu Ala Glu Arg Lys Gln Lys Glu 
        35                  40                  45              


Glu Glu Glu Arg Lys Gln Lys Glu Glu Glu Glu Arg Lys Gln Lys Glu 
    50                  55                  60                  


Glu Glu Glu Arg Lys Leu Lys Glu Glu Gln Glu Arg Lys Ala Ala Glu 
65                  70                  75                  80  


Glu Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys Ala Lys Glu Glu Gln 
                85                  90                  95      


Glu Arg Lys Ala Glu Glu Glu Arg Lys Lys Lys Glu Glu Glu Glu Arg 
            100                 105                 110         


Leu Glu Arg Glu Arg Lys Glu Arg Glu Glu Gln Glu Lys Lys Ala Lys 
        115                 120                 125             


Glu Glu Ala Glu Arg Ile Ala Lys Leu Glu Ala Glu Lys Lys Ala Glu 
    130                 135                 140                 


Glu Glu Arg Lys Ala Lys Glu Glu Glu Glu Arg Lys Ala Lys Glu Glu 
145                 150                 155                 160 


Glu Glu Arg Lys Lys Lys Glu Glu Gln Glu Arg Leu Ala Lys Glu Lys 
                165                 170                 175     


Glu Glu Ala Glu Arg Lys Ala Ala Glu Glu Lys Lys Ala Lys Glu Glu 
            180                 185                 190         


Gln Glu Arg Lys Glu Lys Glu Glu Ala Glu Arg Lys Gln Arg 
        195                 200                 205     


<210>  14
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  14

Gly Phe Gly Thr Trp Phe Arg Phe Asp Glu Asn Thr 
1               5                   10          


<210>  15
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  15

Val Ala Arg Tyr Pro Lys Ser Gly Ile Val 
1               5                   10  


<210>  16
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  16

Asn Val Gly Glu Phe 
1               5   


