                         SEQUENCE LISTING

<110>  The United States of America, as represented by the 
       Secretary, Department of Health and Human Services
       Graham, Barney
       Kong, Wing-Pui
       Modjarrad, Kayvon
       Wang, Lingshu
       Shi, Wei
       Joyce, Michael
       Kanekiyo, Masaru
       Mascola, John
 
<120>  MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS IMMUNOGENS, 
       ANTIBODIES, AND THEIR USE

<130>  4239-93656-02

<150>  US 62/120,353
<151>  2015-02-28

<160>  154   

<170>  PatentIn version 3.5

<210>  1
<211>  363
<212>  DNA
<213>  macaca mulatta

<400>  1
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcgccg tctctggtgg ctccatcagc agtaactact ggaactggat ccgccagtcc      120

ccagggaagg ggctagagtg gattgggtat atctatggtg gtagtgggag caccacctac      180

aacccctccc tcaagagtcg agtcgccatt tcaacagaca cgtccaagga ccagttttcc      240

ctgaagctga gctctgtgac cgccgcggac accgccgtat attactgtgc gagactgctg      300

cccttagggg ggggatactg ctttgactac tggggccagg gagtcctggt caccgtctcc      360

tca                                                                    363


<210>  2
<211>  121
<212>  PRT
<213>  macaca mulatta

<400>  2

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Gly Gly Ser Gly Ser Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Ala Ile Ser Thr Asp Thr Ser Lys Asp Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Pro Leu Gly Gly Gly Tyr Cys Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Val Leu Val Thr Val Ser Ser 
        115                 120     


<210>  3
<211>  339
<212>  DNA
<213>  macaca mulatta

<400>  3
gatattgtga tgacccagac tccattcacc ctgcccgtca cccctggaga ggcggcctcc       60

atctcctgca ggtctagtca gagcctcttc gatagtgatt atggaaacac ctatttggat      120

tggtatctgc agaagccagg ccagtctcca cagctcctga tctatatgct ttccaaccgg      180

gcctctggag tccctgatag gttcagtggc agtgggtcag gcactgattt cacactgaaa      240

atcagccggg tggaggctga ggatgttggg ttatattact gcatgcaaag tgtagagtat      300

ccattcactt tcggccccgg gaccaaactg gatatcaaa                             339


<210>  4
<211>  113
<212>  PRT
<213>  macaca mulatta

<400>  4

Asp Ile Val Met Thr Gln Thr Pro Phe Thr Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ala Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Phe Asp Ser 
            20                  25                  30          


Asp Tyr Gly Asn Thr Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Met Leu Ser Asn Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ser Val Glu Tyr Pro Phe Thr Phe Gly Pro Gly Thr Lys Leu Asp Ile 
            100                 105                 110         


Lys 
    


<210>  5
<211>  393
<212>  DNA
<213>  macaca mulatta

<400>  5
gaggtgcagc tgctggagtc gggcccagga gtggtgaggc cttcggagac cctgtccctc       60

tcctgcgctg tctctggtgg ctccatcagc gatagttacc ggtggagctg gatccgccag      120

cccccaggga agggactgga gtgggttggc tacatctttg ctactggtac gaccaccaac      180

tacaacccct ccctcaagag tcgagtcacc atttcaaaag acacgtccaa gaaccagttc      240

tccttgaagc tgagctctgt gaccgccgcg gacacggccg tttactactg tgcgagagag      300

ccgttcaaat attgtagtgg tggtgtctgc tatgcccaca aggacaactc attggatgtc      360

tggggccagg gagttctggt caccgtctcc tca                                   393


<210>  6
<211>  131
<212>  PRT
<213>  macaca mulatta

<400>  6

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Val Val Arg Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Ser Cys Ala Val Ser Gly Gly Ser Ile Ser Asp Ser 
            20                  25                  30          


Tyr Arg Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Gly Tyr Ile Phe Ala Thr Gly Thr Thr Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Glu Pro Phe Lys Tyr Cys Ser Gly Gly Val Cys Tyr Ala 
            100                 105                 110         


His Lys Asp Asn Ser Leu Asp Val Trp Gly Gln Gly Val Leu Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  7
<211>  318
<212>  DNA
<213>  macaca mulatta

<400>  7
gaaattgtga tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccact       60

ctctcctgca gggccagtca gagtgttagt agcaacttag cctggtacca gcagaaacct      120

gggcaggctc ccaggctcct catccacagt gcgtccagca gggccactgg catcccagac      180

aggttcagtg gcagcgggtc tgggacagag ttcagtctca ccatcagcag tctggaggct      240

gaagatgttg gagtttatca ctgctatcag catagcagcg ggtacacttt cggccccggg      300

accaaactgg atatcaaa                                                    318


<210>  8
<211>  106
<212>  PRT
<213>  macaca mulatta

<400>  8

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


His Ser Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Ser Leu Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr His Cys Tyr Gln His Ser Ser Gly Tyr Thr 
                85                  90                  95      


Phe Gly Pro Gly Thr Lys Leu Asp Ile Lys 
            100                 105     


<210>  9
<211>  351
<212>  DNA
<213>  macaca mulatta

<400>  9
gaggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcgctg tctctggtga ctccatcagc agtaactact ggagctggat ccgccagccc      120

ccagggaagg gactggagtg gattggacgt ttctctggta gtggtgggag caccgacttc      180

aacccctccc tcaagagtcg ggtcaccatt tcaacagaca cgtccaagaa ccagttctcc      240

ctgaacctga ggtctgtgac cgccgcggac acggccgtgt attactgtgc gaaaacctat      300

agcggcacct ttgactactg gggccaggga gtcctggtca ccgtctcctc a               351


<210>  10
<211>  117
<212>  PRT
<213>  macaca mulatta

<400>  10

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Asp Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Phe Ser Gly Ser Gly Gly Ser Thr Asp Phe Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Thr Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Asn Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Thr Tyr Ser Gly Thr Phe Asp Tyr Trp Gly Gln Gly Val Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  11
<211>  321
<212>  DNA
<213>  macaca mulatta

<400>  11
gacattcaga tgacgcagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcgagtca ggacattaac aattatttaa gttggtatca gcagaaacca      120

gggaaagccc ctaagcccct gatctattat gcatccagtt tggaaacagg agtaccttca      180

aggttcagtg gaagtagatc tgggacagat tacactctca ccatcagcag tctgcagctt      240

gaagattttg caacatatta ctgtcaacag tataataatt ccccgtacag ttttggccag      300

gggaccaaag tggagatcaa a                                                321


<210>  12
<211>  107
<212>  PRT
<213>  macaca mulatta

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Leu 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Ser Pro Tyr 
                85                  90                  95      


Ser Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  4062
<212>  DNA
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  13
atgattcact ccgtgttcct gctgatgttc ctgctgactc ctacagagag ctatgtggat       60

gtgggacctg attccgtcaa gagcgcctgc atcgaagtgg acattcagca gaccttcttt      120

gataagacat ggccaagacc catcgacgtg agcaaagccg atggcatcat ctaccctcag      180

gggaggacct attccaatat cacaattact taccagggcc tgttcccata tcagggagac      240

cacggcgata tgtacgtgta ttctgctggc catgcaacag ggaccacacc tcagaagctg      300

tttgtggcta actacagcca ggacgtcaaa cagttcgcaa atggatttgt ggtccgcatc      360

ggcgccgctg caaactctac cggcacagtg atcatttcac ctagcacttc cgcaaccatc      420

cgaaaaatct acccagcctt catgctggga agctccgtgg gcaattttag cgacgggaaa      480

atgggacggt tctttaacca caccctggtg ctgctgcctg atggatgcgg cacactgctg      540

agggctttct actgtatcct ggagccacgc agcggaaacc actgccccgc aggaaatagc      600

tacacctcct ttgccacata tcatactcca gctaccgact gttccgatgg caactacaat      660

cgaaacgcct ctctgaatag tttcaaggaa tacttcaacc tgcggaattg cacattcatg      720

tacacttata acatcaccga ggacgaaatt ctggagtggt tcggaatcac tcagaccgca      780

cagggcgtgc acctgttttc tagtcgctac gtcgacctgt atggcgggaa catgttccag      840

tttgccactc tgcccgtgta cgataccatc aagtactatt ccatcattcc tcattcaatc      900

cgcagcattc agtccgatcg aaaggcttgg gccgctttct acgtgtataa actgcagcca      960

ctgaccttcc tgctggactt tagcgtcgat ggctacatcc ggagagccat tgactgcggg     1020

tttaatgatc tgtcccagct gcactgttct tacgaaagtt tcgacgtgga gtccggcgtg     1080

tattctgtct caagctttga ggccaagccc tctgggagtg tggtcgagca ggctgaagga     1140

gtggagtgcg atttcagtcc tctgctgtca gggacccccc ctcaggtgta caacttcaag     1200

cggctggtct ttactaactg taactacaat ctgaccaagc tgctgtcact gttcagcgtg     1260

aatgacttta catgctccca gatcagcccc gcagccattg ctagtaactg ttactcctct     1320

ctgatcctgg actacttctc atatccactg agtatgaaga gcgacctgag cgtgagttca     1380

gccggcccca tcagccagtt caactataaa cagagcttca gcaatcctac atgcctgatt     1440

ctggctactg tgccacataa tctgactacc atcactaagc ccctgaaata ctcctatatt     1500

aacaagtgca gccggttcct gtccgacgat agaaccgaag tgccacagct ggtcaacgcc     1560

aatcagtact ctccctgtgt gagtatcgtc ccttcaaccg tgtgggaaga cggggattac     1620

tatagaaaac agctgagccc cctggaggga ggaggatggc tggtggcatc cggatctaca     1680

gtcgccatga ctgagcagct gcagatgggg ttcggaatca cagtgcagta cggcacagac     1740

actaactctg tctgtcccaa gctggaattc gctaacgata ctaagatcgc aagtcagctg     1800

ggaaactgcg tggagtactc tctgtatggc gtgagtggca gaggggtctt ccagaattgt     1860

accgcagtgg gcgtccgaca gcagcggttt gtgtacgacg cctatcagaa tctggtcggc     1920

tactatagcg acgatgggaa ctactattgc ctgagggcct gtgtgagcgt ccctgtgtcc     1980

gtcatctacg ataaggaaac caaaacacac gccacactgt tcgggtccgt ggcttgcgag     2040

catattagct ccacaatgtc tcagtacagt agatcaacta ggtcaatgct gaagaggcgc     2100

gatagcacct atggacctct gcagacacca gtggggtgtg tcctgggact ggtgaactct     2160

agtctgtttg tcgaggactg caagctgccc ctgggccaga gcctgtgcgc cctgcccgac     2220

acccccagca ccctgacccc ccggagcgtg cggagcgtgc ccggcgagat gcggctggcc     2280

agcatcgcct tcaaccaccc catccaggtg gaccagctga acagcagcta cttcaagctg     2340

agcatcccca ccaacttcag cttcggcgtg acccaggagt acatccagac caccatccag     2400

aaggtgaccg tggactgcaa gcagtacgtg tgcaacggct tccagaagtg cgagcagctg     2460

ctgcgggagt acggccagtt ctgcagcaag atcaaccagg ccctgcacgg cgccaacctg     2520

cggcaggacg acagcgtgcg gaacctgttc gccagcgtga agagcagcca gagcagcccc     2580

atcatccccg gcttcggcgg cgacttcaac ctgaccctgc tggagcccgt gagcatcagc     2640

accggcagcc ggagcgcccg gagcgccatc gaggacctgc tgttcgacaa ggtgaccatc     2700

gccgaccccg gctacatgca gggctacgac gactgcatgc agcagggccc cgccagcgcc     2760

cgggacctga tctgcgccca gtacgtggcc ggctacaagg tgctgccccc cctgatggac     2820

gtgaacatgg aggccgccta caccagcagc ctgctgggca gcatcgccgg cgtgggctgg     2880

accgccggcc tgagcagctt cgccgccatc cccttcgccc agagcatctt ctaccggctg     2940

aacggcgtgg gcatcaccca gcaggtgctg agcgagaacc agaagctgat cgccaacaag     3000

ttcaaccagg ccctgggcgc catgcagacc ggcttcacca ccaccaacga ggccttccac     3060

aaggtgcagg acgccgtgaa caacaacgcc caggccctga gcaagctggc cagcgagctg     3120

agcaacacct tcggcgccat cagcgccagc atcggcgaca tcatccagcg gctggacgtg     3180

ctggagcagg acgcccagat cgaccggctg atcaacggcc ggctgaccac cctgaacgcc     3240

ttcgtggccc agcagctggt gcggagcgag agcgccgccc tgagcgccca gctggccaag     3300

gacaaggtga acgagtgcgt gaaggcccag agcaagcgga gcggcttctg cggccagggc     3360

acccacatcg tgagcttcgt ggtgaacgcc cccaacggcc tgtacttcat gcacgtgggc     3420

tactacccca gcaaccacat cgaggtggtg agcgcctacg gcctgtgcga cgccgccaac     3480

cccaccaact gcatcgcccc cgtgaacggc tacttcatca agaccaacaa cacccggatc     3540

gtggacgagt ggagctacac cggcagcagc ttctacgccc ccgagcccat caccagcctg     3600

aacaccaagt acgtggcccc ccaggtgacc taccagaaca tcagcaccaa cctgcccccc     3660

cccctgctgg gcaacagcac cggcatcgac ttccaggacg agctggacga gttcttcaag     3720

aacgtgagca ccagcatccc caacttcggc agcctgaccc agatcaacac caccctgctg     3780

gacctgacct acgagatgct gagcctgcag caggtggtga aggccctgaa cgagagctac     3840

atcgacctga aggagctggg caactacacc tactacaaca agtggccctg gtacatctgg     3900

ctgggcttca tcgccggcct ggtggccctg gccctgtgcg tgttcttcat cctgtgctgc     3960

accggctgcg gcaccaactg catgggcaag ctgaagtgca accggtgctg cgaccggtac     4020

gaggagtacg acctggagcc ccacaaggtg cacgtgcact ga                        4062


<210>  14
<211>  1353
<212>  PRT
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  14

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe His  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  Tyr Tyr Asn 
    1280                 1285                 1290             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Val 
    1295                 1300                 1305             


Ala Leu  Ala Leu Cys Val Phe  Phe Ile Leu Cys Cys  Thr Gly Cys 
    1310                 1315                 1320             


Gly Thr  Asn Cys Met Gly Lys  Leu Lys Cys Asn Arg  Cys Cys Asp 
    1325                 1330                 1335             


Arg Tyr  Glu Glu Tyr Asp Leu  Glu Pro His Lys Val  His Val His 
    1340                 1345                 1350             


<210>  15
<211>  2259
<212>  DNA
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  15
atgattcact ccgtgttcct gctgatgttc ctgctgactc ctacagagag ctatgtggat       60

gtgggacctg attccgtcaa gagcgcctgc atcgaagtgg acattcagca gaccttcttt      120

gataagacat ggccaagacc catcgacgtg agcaaagccg atggcatcat ctaccctcag      180

gggaggacct attccaatat cacaattact taccagggcc tgttcccata tcagggagac      240

cacggcgata tgtacgtgta ttctgctggc catgcaacag ggaccacacc tcagaagctg      300

tttgtggcta actacagcca ggacgtcaaa cagttcgcaa atggatttgt ggtccgcatc      360

ggcgccgctg caaactctac cggcacagtg atcatttcac ctagcacttc cgcaaccatc      420

cgaaaaatct acccagcctt catgctggga agctccgtgg gcaattttag cgacgggaaa      480

atgggacggt tctttaacca caccctggtg ctgctgcctg atggatgcgg cacactgctg      540

agggctttct actgtatcct ggagccacgc agcggaaacc actgccccgc aggaaatagc      600

tacacctcct ttgccacata tcatactcca gctaccgact gttccgatgg caactacaat      660

cgaaacgcct ctctgaatag tttcaaggaa tacttcaacc tgcggaattg cacattcatg      720

tacacttata acatcaccga ggacgaaatt ctggagtggt tcggaatcac tcagaccgca      780

cagggcgtgc acctgttttc tagtcgctac gtcgacctgt atggcgggaa catgttccag      840

tttgccactc tgcccgtgta cgataccatc aagtactatt ccatcattcc tcattcaatc      900

cgcagcattc agtccgatcg aaaggcttgg gccgctttct acgtgtataa actgcagcca      960

ctgaccttcc tgctggactt tagcgtcgat ggctacatcc ggagagccat tgactgcggg     1020

tttaatgatc tgtcccagct gcactgttct tacgaaagtt tcgacgtgga gtccggcgtg     1080

tattctgtct caagctttga ggccaagccc tctgggagtg tggtcgagca ggctgaagga     1140

gtggagtgcg atttcagtcc tctgctgtca gggacccccc ctcaggtgta caacttcaag     1200

cggctggtct ttactaactg taactacaat ctgaccaagc tgctgtcact gttcagcgtg     1260

aatgacttta catgctccca gatcagcccc gcagccattg ctagtaactg ttactcctct     1320

ctgatcctgg actacttctc atatccactg agtatgaaga gcgacctgag cgtgagttca     1380

gccggcccca tcagccagtt caactataaa cagagcttca gcaatcctac atgcctgatt     1440

ctggctactg tgccacataa tctgactacc atcactaagc ccctgaaata ctcctatatt     1500

aacaagtgca gccggttcct gtccgacgat agaaccgaag tgccacagct ggtcaacgcc     1560

aatcagtact ctccctgtgt gagtatcgtc ccttcaaccg tgtgggaaga cggggattac     1620

tatagaaaac agctgagccc cctggaggga ggaggatggc tggtggcatc cggatctaca     1680

gtcgccatga ctgagcagct gcagatgggg ttcggaatca cagtgcagta cggcacagac     1740

actaactctg tctgtcccaa gctggaattc gctaacgata ctaagatcgc aagtcagctg     1800

ggaaactgcg tggagtactc tctgtatggc gtgagtggca gaggggtctt ccagaattgt     1860

accgcagtgg gcgtccgaca gcagcggttt gtgtacgacg cctatcagaa tctggtcggc     1920

tactatagcg acgatgggaa ctactattgc ctgagggcct gtgtgagcgt ccctgtgtcc     1980

gtcatctacg ataaggaaac caaaacacac gccacactgt tcgggtccgt ggcttgcgag     2040

catattagct ccacaatgtc tcagtacagt agatcaacta ggtcaatgct gaagaggcgc     2100

gatagcacct atggacctct gcagacacca gtggggtgtg tcctgggact ggtgaactct     2160

agtctgtttg tcgaggactg caagctgccc ctgggccaga gcctgtgcgc cctgcccgac     2220

acccccagca ccctgacccc ccggagcgtg cggagctga                            2259


<210>  16
<211>  752
<212>  PRT
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  16

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


<210>  17
<211>  720
<212>  DNA
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  17
gaggccaagc cctctgggag tgtggtcgag caggctgaag gagtggagtg cgatttcagt       60

cctctgctgt cagggacccc ccctcaggtg tacaacttca agcggctggt ctttactaac      120

tgtaactaca atctgaccaa gctgctgtca ctgttcagcg tgaatgactt tacatgctcc      180

cagatcagcc ccgcagccat tgctagtaac tgttactcct ctctgatcct ggactacttc      240

tcatatccac tgagtatgaa gagcgacctg agcgtgagtt cagccggccc catcagccag      300

ttcaactata aacagagctt cagcaatcct acatgcctga ttctggctac tgtgccacat      360

aatctgacta ccatcactaa gcccctgaaa tactcctata ttaacaagtg cagccggttc      420

ctgtccgacg atagaaccga agtgccacag ctggtcaacg ccaatcagta ctctccctgt      480

gtgagtatcg tcccttcaac cgtgtgggaa gacggggatt actatagaaa acagctgagc      540

cccctggagg gaggaggatg gctggtggca tccggatcta cagtcgccat gactgagcag      600

ctgcagatgg ggttcggaat cacagtgcag tacggcacag acactaactc tgtctgtccc      660

aagctggaat tcgctaacga tactaagatc gcaagtcagc tgggaaactg cgtggagtac      720


<210>  18
<211>  240
<212>  PRT
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  18

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 


Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr 
225                 230                 235                 240 


<210>  19
<211>  3870
<212>  DNA
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  19
atgattcact ccgtgttcct gctgatgttc ctgctgactc ctacagagag ctatgtggat       60

gtgggacctg attccgtcaa gagcgcctgc atcgaagtgg acattcagca gaccttcttt      120

gataagacat ggccaagacc catcgacgtg agcaaagccg atggcatcat ctaccctcag      180

gggaggacct attccaatat cacaattact taccagggcc tgttcccata tcagggagac      240

cacggcgata tgtacgtgta ttctgctggc catgcaacag ggaccacacc tcagaagctg      300

tttgtggcta actacagcca ggacgtcaaa cagttcgcaa atggatttgt ggtccgcatc      360

ggcgccgctg caaactctac cggcacagtg atcatttcac ctagcacttc cgcaaccatc      420

cgaaaaatct acccagcctt catgctggga agctccgtgg gcaattttag cgacgggaaa      480

atgggacggt tctttaacca caccctggtg ctgctgcctg atggatgcgg cacactgctg      540

agggctttct actgtatcct ggagccacgc agcggaaacc actgccccgc aggaaatagc      600

tacacctcct ttgccacata tcatactcca gctaccgact gttccgatgg caactacaat      660

cgaaacgcct ctctgaatag tttcaaggaa tacttcaacc tgcggaattg cacattcatg      720

tacacttata acatcaccga ggacgaaatt ctggagtggt tcggaatcac tcagaccgca      780

cagggcgtgc acctgttttc tagtcgctac gtcgacctgt atggcgggaa catgttccag      840

tttgccactc tgcccgtgta cgataccatc aagtactatt ccatcattcc tcattcaatc      900

cgcagcattc agtccgatcg aaaggcttgg gccgctttct acgtgtataa actgcagcca      960

ctgaccttcc tgctggactt tagcgtcgat ggctacatcc ggagagccat tgactgcggg     1020

tttaatgatc tgtcccagct gcactgttct tacgaaagtt tcgacgtgga gtccggcgtg     1080

tattctgtct caagctttga ggccaagccc tctgggagtg tggtcgagca ggctgaagga     1140

gtggagtgcg atttcagtcc tctgctgtca gggacccccc ctcaggtgta caacttcaag     1200

cggctggtct ttactaactg taactacaat ctgaccaagc tgctgtcact gttcagcgtg     1260

aatgacttta catgctccca gatcagcccc gcagccattg ctagtaactg ttactcctct     1320

ctgatcctgg actacttctc atatccactg agtatgaaga gcgacctgag cgtgagttca     1380

gccggcccca tcagccagtt caactataaa cagagcttca gcaatcctac atgcctgatt     1440

ctggctactg tgccacataa tctgactacc atcactaagc ccctgaaata ctcctatatt     1500

aacaagtgca gccggttcct gtccgacgat agaaccgaag tgccacagct ggtcaacgcc     1560

aatcagtact ctccctgtgt gagtatcgtc ccttcaaccg tgtgggaaga cggggattac     1620

tatagaaaac agctgagccc cctggaggga ggaggatggc tggtggcatc cggatctaca     1680

gtcgccatga ctgagcagct gcagatgggg ttcggaatca cagtgcagta cggcacagac     1740

actaactctg tctgtcccaa gctggaattc gctaacgata ctaagatcgc aagtcagctg     1800

ggaaactgcg tggagtactc tctgtatggc gtgagtggca gaggggtctt ccagaattgt     1860

accgcagtgg gcgtccgaca gcagcggttt gtgtacgacg cctatcagaa tctggtcggc     1920

tactatagcg acgatgggaa ctactattgc ctgagggcct gtgtgagcgt ccctgtgtcc     1980

gtcatctacg ataaggaaac caaaacacac gccacactgt tcgggtccgt ggcttgcgag     2040

catattagct ccacaatgtc tcagtacagt agatcaacta ggtcaatgct gaagaggcgc     2100

gatagcacct atggacctct gcagacacca gtggggtgtg tcctgggact ggtgaactct     2160

agtctgtttg tcgaggactg caagctgccc ctgggccaga gcctgtgcgc cctgcccgac     2220

acccccagca ccctgacccc ccggagcgtg cggagcgtgc ccggcgagat gcggctggcc     2280

agcatcgcct tcaaccaccc catccaggtg gaccagctga acagcagcta cttcaagctg     2340

agcatcccca ccaacttcag cttcggcgtg acccaggagt acatccagac caccatccag     2400

aaggtgaccg tggactgcaa gcagtacgtg tgcaacggct tccagaagtg cgagcagctg     2460

ctgcgggagt acggccagtt ctgcagcaag atcaaccagg ccctgcacgg cgccaacctg     2520

cggcaggacg acagcgtgcg gaacctgttc gccagcgtga agagcagcca gagcagcccc     2580

atcatccccg gcttcggcgg cgacttcaac ctgaccctgc tggagcccgt gagcatcagc     2640

accggcagcc ggagcgcccg gagcgccatc gaggacctgc tgttcgacaa ggtgaccatc     2700

gccgaccccg gctacatgca gggctacgac gactgcatgc agcagggccc cgccagcgcc     2760

cgggacctga tctgcgccca gtacgtggcc ggctacaagg tgctgccccc cctgatggac     2820

gtgaacatgg aggccgccta caccagcagc ctgctgggca gcatcgccgg cgtgggctgg     2880

accgccggcc tgagcagctt cgccgccatc cccttcgccc agagcatctt ctaccggctg     2940

aacggcgtgg gcatcaccca gcaggtgctg agcgagaacc agaagctgat cgccaacaag     3000

ttcaaccagg ccctgggcgc catgcagacc ggcttcacca ccaccaacga ggccttccac     3060

aaggtgcagg acgccgtgaa caacaacgcc caggccctga gcaagctggc cagcgagctg     3120

agcaacacct tcggcgccat cagcgccagc atcggcgaca tcatccagcg gctggacgtg     3180

ctggagcagg acgcccagat cgaccggctg atcaacggcc ggctgaccac cctgaacgcc     3240

ttcgtggccc agcagctggt gcggagcgag agcgccgccc tgagcgccca gctggccaag     3300

gacaaggtga acgagtgcgt gaaggcccag agcaagcgga gcggcttctg cggccagggc     3360

acccacatcg tgagcttcgt ggtgaacgcc cccaacggcc tgtacttcat gcacgtgggc     3420

tactacccca gcaaccacat cgaggtggtg agcgcctacg gcctgtgcga cgccgccaac     3480

cccaccaact gcatcgcccc cgtgaacggc tacttcatca agaccaacaa cacccggatc     3540

gtggacgagt ggagctacac cggcagcagc ttctacgccc ccgagcccat caccagcctg     3600

aacaccaagt acgtggcccc ccaggtgacc taccagaaca tcagcaccaa cctgcccccc     3660

cccctgctgg gcaacagcac cggcatcgac ttccaggacg agctggacga gttcttcaag     3720

aacgtgagca ccagcatccc caacttcggc agcctgaccc agatcaacac caccctgctg     3780

gacctgacct acgagatgct gagcctgcag caggtggtga aggccctgaa cgagagctac     3840

atcgacctga aggagctggg caactacacc                                      3870


<210>  20
<211>  1290
<212>  PRT
<213>  Middle East Respiratory Syndrome Coronavirus

<400>  20

Met Ile His Ser Val Phe Leu Leu Met Phe Leu Leu Thr Pro Thr Glu 
1               5                   10                  15      


Ser Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu 
            20                  25                  30          


Val Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile 
        35                  40                  45              


Asp Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr 
    50                  55                  60                  


Ser Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp 
65                  70                  75                  80  


His Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr 
                85                  90                  95      


Pro Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe 
            100                 105                 110         


Ala Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly 
        115                 120                 125             


Thr Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr 
    130                 135                 140                 


Pro Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys 
145                 150                 155                 160 


Met Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys 
                165                 170                 175     


Gly Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly 
            180                 185                 190         


Asn His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His 
        195                 200                 205             


Thr Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser 
    210                 215                 220                 


Leu Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met 
225                 230                 235                 240 


Tyr Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile 
                245                 250                 255     


Thr Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp 
            260                 265                 270         


Leu Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp 
        275                 280                 285             


Thr Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln 
    290                 295                 300                 


Ser Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro 
305                 310                 315                 320 


Leu Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala 
                325                 330                 335     


Ile Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu 
            340                 345                 350         


Ser Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala 
        355                 360                 365             


Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp 
    370                 375                 380                 


Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys 
385                 390                 395                 400 


Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser 
                405                 410                 415     


Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala 
            420                 425                 430         


Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr 
        435                 440                 445             


Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile 
    450                 455                 460                 


Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile 
465                 470                 475                 480 


Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys 
                485                 490                 495     


Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg Thr 
            500                 505                 510         


Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser 
        515                 520                 525             


Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln 
    530                 535                 540                 


Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr 
545                 550                 555                 560 


Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln 
                565                 570                 575     


Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn 
            580                 585                 590         


Asp Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu 
        595                 600                 605             


Tyr Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly 
    610                 615                 620                 


Val Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly 
625                 630                 635                 640 


Tyr Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser 
                645                 650                 655     


Val Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr 
            660                 665                 670         


Leu Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln 
        675                 680                 685             


Tyr Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr 
    690                 695                 700                 


Gly Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser 
705                 710                 715                 720 


Ser Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys 
                725                 730                 735     


Ala Leu Pro Asp Thr Pro Ser Thr Leu Thr Pro Arg Ser Val Arg Ser 
            740                 745                 750         


Val Pro Gly Glu Met Arg Leu Ala Ser Ile Ala Phe Asn His Pro Ile 
        755                 760                 765             


Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys Leu Ser Ile Pro Thr 
    770                 775                 780                 


Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile Gln Thr Thr Ile Gln 
785                 790                 795                 800 


Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys Asn Gly Phe Gln Lys 
                805                 810                 815     


Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe Cys Ser Lys Ile Asn 
            820                 825                 830         


Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp Asp Ser Val Arg Asn 
        835                 840                 845             


Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser Pro Ile Ile Pro Gly 
    850                 855                 860                 


Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu Pro Val Ser Ile Ser 
865                 870                 875                 880 


Thr Gly Ser Arg Ser Ala Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
                885                 890                 895     


Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln Gly Tyr Asp Asp Cys 
            900                 905                 910         


Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu Ile Cys Ala Gln Tyr 
        915                 920                 925             


Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met Asp Val Asn Met Glu 
    930                 935                 940                 


Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile Ala Gly Val Gly Trp 
945                 950                 955                 960 


Thr Ala Gly Leu Ser Ser Phe Ala Ala Ile Pro Phe Ala Gln Ser Ile 
                965                 970                 975     


Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln Gln Val Leu Ser Glu 
            980                 985                 990         


Asn Gln Lys Leu Ile Ala Asn Lys  Phe Asn Gln Ala Leu  Gly Ala Met 
        995                 1000                 1005             


Gln Thr  Gly Phe Thr Thr Thr  Asn Glu Ala Phe His  Lys Val Gln 
    1010                 1015                 1020             


Asp Ala  Val Asn Asn Asn Ala  Gln Ala Leu Ser Lys  Leu Ala Ser 
    1025                 1030                 1035             


Glu Leu  Ser Asn Thr Phe Gly  Ala Ile Ser Ala Ser  Ile Gly Asp 
    1040                 1045                 1050             


Ile Ile  Gln Arg Leu Asp Val  Leu Glu Gln Asp Ala  Gln Ile Asp 
    1055                 1060                 1065             


Arg Leu  Ile Asn Gly Arg Leu  Thr Thr Leu Asn Ala  Phe Val Ala 
    1070                 1075                 1080             


Gln Gln  Leu Val Arg Ser Glu  Ser Ala Ala Leu Ser  Ala Gln Leu 
    1085                 1090                 1095             


Ala Lys  Asp Lys Val Asn Glu  Cys Val Lys Ala Gln  Ser Lys Arg 
    1100                 1105                 1110             


Ser Gly  Phe Cys Gly Gln Gly  Thr His Ile Val Ser  Phe Val Val 
    1115                 1120                 1125             


Asn Ala  Pro Asn Gly Leu Tyr  Phe Met His Val Gly  Tyr Tyr Pro 
    1130                 1135                 1140             


Ser Asn  His Ile Glu Val Val  Ser Ala Tyr Gly Leu  Cys Asp Ala 
    1145                 1150                 1155             


Ala Asn  Pro Thr Asn Cys Ile  Ala Pro Val Asn Gly  Tyr Phe Ile 
    1160                 1165                 1170             


Lys Thr  Asn Asn Thr Arg Ile  Val Asp Glu Trp Ser  Tyr Thr Gly 
    1175                 1180                 1185             


Ser Ser  Phe Tyr Ala Pro Glu  Pro Ile Thr Ser Leu  Asn Thr Lys 
    1190                 1195                 1200             


Tyr Val  Ala Pro Gln Val Thr  Tyr Gln Asn Ile Ser  Thr Asn Leu 
    1205                 1210                 1215             


Pro Pro  Pro Leu Leu Gly Asn  Ser Thr Gly Ile Asp  Phe Gln Asp 
    1220                 1225                 1230             


Glu Leu  Asp Glu Phe Phe Lys  Asn Val Ser Thr Ser  Ile Pro Asn 
    1235                 1240                 1245             


Phe Gly  Ser Leu Thr Gln Ile  Asn Thr Thr Leu Leu  Asp Leu Thr 
    1250                 1255                 1260             


Tyr Glu  Met Leu Ser Leu Gln  Gln Val Val Lys Ala  Leu Asn Glu 
    1265                 1270                 1275             


Ser Tyr  Ile Asp Leu Lys Glu  Leu Gly Asn Tyr Thr  
    1280                 1285                 1290 


<210>  21
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ferritin nanoparticle sequence

<400>  21

Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu 
1               5                   10                  15      


Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser 
            20                  25                  30          


Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe 
        35                  40                  45              


Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile 
    50                  55                  60                  


Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser 
65                  70                  75                  80  


Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala 
                85                  90                  95      


Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp 
            100                 105                 110         


His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp 
        115                 120                 125             


Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu 
    130                 135                 140                 


Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala 
145                 150                 155                 160 


Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser 
                165                 170             


<210>  22
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  22

Glu Ala Lys Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu 
1               5                   10                  15      


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
            20                  25                  30          


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
        35                  40                  45              


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
    50                  55                  60                  


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
65                  70                  75                  80  


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
                85                  90                  95      


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
            100                 105                 110         


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
        115                 120                 125             


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp 
    130                 135                 140                 


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
145                 150                 155                 160 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
                165                 170                 175     


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
            180                 185                 190         


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
        195                 200                 205             


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe 
    210                 215                 220                 


Ala Asn Asp Thr Lys Ile Ala Ser Gln Leu Gly Ser Gly Glu Ser Gln 
225                 230                 235                 240 


Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys Leu Leu Asn Glu Gln 
                245                 250                 255     


Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr Met Ser Met Ser Ser 
            260                 265                 270         


Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly Leu Phe Leu Phe Asp 
        275                 280                 285             


His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys Leu Ile Ile Phe Leu 
    290                 295                 300                 


Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser Ile Ser Ala Pro Glu 
305                 310                 315                 320 


His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln Lys Ala Tyr Glu His 
                325                 330                 335     


Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile Val Asp His Ala Ile 
            340                 345                 350         


Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu Gln Trp Tyr Val Ala 
        355                 360                 365             


Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp Ile Leu Asp Lys Ile 
    370                 375                 380                 


Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr Leu Ala Asp Gln Tyr 
385                 390                 395                 400 


Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly Ser 
                405                 410         


<210>  23
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  23

Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val 
1               5                   10                  15      


Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr 
            20                  25                  30          


Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile 
        35                  40                  45              


Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp 
    50                  55                  60                  


Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser 
65                  70                  75                  80  


Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro 
                85                  90                  95      


Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr 
            100                 105                 110         


Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser 
        115                 120                 125             


Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser 
    130                 135                 140                 


Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr 
145                 150                 155                 160 


Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala 
                165                 170                 175     


Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly 
            180                 185                 190         


Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu 
        195                 200                 205             


Ser Gly Glu Ser Gln Val Arg Gln Gln Phe Ser Lys Asp Ile Glu Lys 
    210                 215                 220                 


Leu Leu Asn Glu Gln Val Asn Lys Glu Met Gln Ser Ser Asn Leu Tyr 
225                 230                 235                 240 


Met Ser Met Ser Ser Trp Cys Tyr Thr His Ser Leu Asp Gly Ala Gly 
                245                 250                 255     


Leu Phe Leu Phe Asp His Ala Ala Glu Glu Tyr Glu His Ala Lys Lys 
            260                 265                 270         


Leu Ile Ile Phe Leu Asn Glu Asn Asn Val Pro Val Gln Leu Thr Ser 
        275                 280                 285             


Ile Ser Ala Pro Glu His Lys Phe Glu Gly Leu Thr Gln Ile Phe Gln 
    290                 295                 300                 


Lys Ala Tyr Glu His Glu Gln His Ile Ser Glu Ser Ile Asn Asn Ile 
305                 310                 315                 320 


Val Asp His Ala Ile Lys Ser Lys Asp His Ala Thr Phe Asn Phe Leu 
                325                 330                 335     


Gln Trp Tyr Val Ala Glu Gln His Glu Glu Glu Val Leu Phe Lys Asp 
            340                 345                 350         


Ile Leu Asp Lys Ile Glu Leu Ile Gly Asn Glu Asn His Gly Leu Tyr 
        355                 360                 365             


Leu Ala Asp Gln Tyr Val Lys Gly Ile Ala Lys Ser Arg Lys Ser Gly 
    370                 375                 380                 


Ser 
385 


<210>  24
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal sequence

<400>  24

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Pro Gln Gly Val Leu Ala 
            20                  25                  30  


<210>  25
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal Sequence

<400>  25

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala 
            20                  


<210>  26
<211>  5778
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  26
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

gggaacttcc atagcccata tatggagttc cgcgttacat aacttacggg aatttccaaa      420

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      480

gtaacgccaa tagggaactt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      540

cacttgggaa tttccaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg      600

ggaacttcca taagcttgca ttatgcccag tacatgacct tatgggaatt tcctacttgg      660

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      720

aatgggcgtg gatagcggtt tgactcacgg gaacttccaa gtctccaccc cattgacgtc      780

aatgggagtt tgttttgact caccaaaatc ayacgggaat tcccaaaatg tcgtaacaac      840

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga      900

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat      960

agaagacacc gggaccgatc cagcctccat cggctcgcat ctctccttca cgcgcccgcc     1020

gccctacctg aggccgccat ccacgccggt tgagtcgcgt tctgccgcct cccgcctgtg     1080

gtgcctcctg aactgcgtcc gccgtctagg taagtttaaa gctcaggtcg agaccgggcc     1140

tttgtccggc gctcccttgg agcctaccta gactcagccg gctctccacg ctttgcctga     1200

ccctgcttgc tcaactctag ttaacggtgg agggcagtgt agtctgagca gtactcgttg     1260

ctgccgcgcg cgccaccaga cataatagct gacagactaa cagactgttc ctttccatgg     1320

gtcttttctg cagtcaccgt cgtcgacacg tgtgatcaga tatcgcggcc gctctagaga     1380

tatcgccacc atggacagca agggcagcag ccagaagggc agcagactgc tgctgctgct     1440

ggtggtgagc aacctgctgc tgcctcaggg cgtgctagcc gaggccaagc cctctgggag     1500

tgtggtcgag caggctgaag gagtggagtg cgatttcagt cctctgctgt cagggacccc     1560

ccctcaggtg tacaacttca agcggctggt ctttactaac tgtaactaca atctgaccaa     1620

gctgctgtca ctgttcagcg tgaatgactt tacatgctcc cagatcagcc ccgcagccat     1680

tgctagtaac tgttactcct ctctgatcct ggactacttc tcatatccac tgagtatgaa     1740

gagcgacctg agcgtgagtt cagccggccc catcagccag ttcaactata aacagagctt     1800

cagcaatcct acatgcctga ttctggctac tgtgccacat aatctgacta ccatcactaa     1860

gcccctgaaa tactcctata ttaacaagtg cagccggttc ctgtccgacg atagaaccga     1920

agtgccacag ctggtcaacg ccaatcagta ctctccctgt gtgagtatcg tcccttcaac     1980

cgtgtgggaa gacggggatt actatagaaa acagctgagc cccctggagg gaggaggatg     2040

gctggtggca tccggatcta cagtcgccat gactgagcag ctgcagatgg ggttcggaat     2100

cacagtgcag tacggcacag acactaactc tgtctgtccc aagctggaat tcgctaacga     2160

tactaagatc gcaagtcagc tgggatccgg agagagccag gtgaggcagc agttcagcaa     2220

ggacatcgag aagctgctga acgagcaggt gaacaaggag atgcagagca gcaacctgta     2280

catgagcatg agcagctggt gctacaccca cagcctggac ggcgccggcc tgttcctgtt     2340

cgaccacgcc gccgaggagt acgagcacgc caagaagctg atcatcttcc tgaacgagaa     2400

caacgtgccc gtgcagctga ccagcatcag cgcccccgag cacaagttcg agggcctgac     2460

ccagatcttc cagaaggcct acgagcacga gcagcacatc agcgagagca tcaacaacat     2520

cgtggaccac gccatcaaga gcaaggacca cgccaccttc aacttcctgc agtggtacgt     2580

ggccgagcag cacgaggagg aggtgctgtt caaggacatc ctggacaaga tcgagctgat     2640

cggcaacgag aaccacggcc tgtacctggc cgaccagtac gtgaagggca tcgccaagag     2700

caggaagagc ggatcctagc atcatcatca tcattagtct ggaagggcga attgatccag     2760

atctgctgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt     2820

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca     2880

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     2940

ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg gtacccaggt     3000

gctgaagaat tgacccggtt cctcctgggc cagaaagaag caggcacatc cccttctctg     3060

tgacacaccc tgtccacgcc cctggttctt agttccagcc ccactcatag gacactcata     3120

gctcaggagg gctccgcctt caatcccacc cgctaaagta cttggagcgg tctctccctc     3180

cctcatcagc ccaccaaacc aaacctagcc tccaagagtg ggaagaaatt aaagcaagat     3240

aggctattaa gtgcagaggg agagaaaatg cctccaacat gtgaggaagt aatgagagaa     3300

atcatagaat tttaaggcca tgatttaagg ccatcatggc cttaatcttc cgcttcctcg     3360

ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag     3420

gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa     3480

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     3540

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     3600

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     3660

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     3720

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     3780

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     3840

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     3900

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac     3960

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga     4020

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc     4080

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     4140

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca     4200

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt     4260

atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca     4320

gcgatctgtc tatttcgttc atccatagtt gcctgactcg gggggggggg gcgctgaggt     4380

ctgcctcgtg aagaaggtgt tgctgactca taccaggcct gaatcgcccc atcatccagc     4440

cagaaagtga gggagccacg gttgatgaga gctttgttgt aggtggacca gttggtgatt     4500

ttgaactttt gctttgccac ggaacggtct gcgttgtcgg gaagatgcgt gatctgatcc     4560

ttcaactcag caaaagttcg atttattcaa caaagccgcc gtcccgtcaa gtcagcgtaa     4620

tgctctgcca gtgttacaac caattaacca attctgatta gaaaaactca tcgagcatca     4680

aatgaaactg caatttattc atatcaggat tatcaatacc atatttttga aaaagccgtt     4740

tctgtaatga aggagaaaac tcaccgaggc agttccatag gatggcaaga tcctggtatc     4800

ggtctgcgat tccgactcgt ccaacatcaa tacaacctat taatttcccc tcgtcaaaaa     4860

taaggttatc aagtgagaaa tcaccatgag tgacgactga atccggtgag aatggcaaaa     4920

gcttatgcat ttctttccag acttgttcaa caggccagcc attacgctcg tcatcaaaat     4980

cactcgcatc aaccaaaccg ttattcattc gtgattgcgc ctgagcgaga cgaaatacgc     5040

gatcgctgtt aaaaggacaa ttacaaacag gaatcgaatg caaccggcgc aggaacactg     5100

ccagcgcatc aacaatattt tcacctgaat caggatattc ttctaatacc tggaatgctg     5160

ttttcccggg gatcgcagtg gtgagtaacc atgcatcatc aggagtacgg ataaaatgct     5220

tgatggtcgg aagaggcata aattccgtca gccagtttag tctgaccatc tcatctgtaa     5280

catcattggc aacgctacct ttgccatgtt tcagaaacaa ctctggcgca tcgggcttcc     5340

catacaatcg atagattgtc gcacctgatt gcccgacatt atcgcgagcc catttatacc     5400

catataaatc agcatccatg ttggaattta atcgcggcct cgagcaagac gtttcccgtt     5460

gaatatggct cataacaccc cttgtattac tgtttatgta agcagacagt tttattgttc     5520

atgatgatat atttttatct tgtgcaatgt aacatcagag attttgagac acaacgtggc     5580

tttccccccc cccccattat tgaagcattt atcagggtta ttgtctcatg agcggataca     5640

tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag     5700

tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa aataggcgta     5760

tcacgaggcc ctttcgtc                                                   5778


<210>  27
<211>  5696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  27
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

gggaacttcc atagcccata tatggagttc cgcgttacat aacttacggg aatttccaaa      420

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      480

gtaacgccaa tagggaactt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      540

cacttgggaa tttccaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg      600

ggaacttcca taagcttgca ttatgcccag tacatgacct tatgggaatt tcctacttgg      660

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      720

aatgggcgtg gatagcggtt tgactcacgg gaacttccaa gtctccaccc cattgacgtc      780

aatgggagtt tgttttgact caccaaaatc aacgggaatt cccaaaatgt cgtaacaact      840

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      900

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      960

gaagacaccg ggaccgatcc agcctccatc ggctcgcatc tctccttcac gcgcccgccg     1020

ccctacctga ggccgccatc cacgccggtt gagtcgcgtt ctgccgcctc ccgcctgtgg     1080

tgcctcctga actgcgtccg ccgtctaggt aagtttaaag ctcaggtcga gaccgggcct     1140

ttgtccggcg ctcccttgga gcctacctag actcagccgg ctctccacgc tttgcctgac     1200

cctgcttgct caactctagt taacggtgga gggcagtgta gtctgagcag tactcgttgc     1260

tgccgcgcgc gccaccagac ataatagctg acagactaac agactgttcc tttccatggg     1320

tcttttctgc agtcaccgtc gtcgacacgt gtgatcagat atcgcggccg ctctagagat     1380

atcgccacca tggacagcaa gggcagcagc cagaagggca gcagactgct gctgctgctg     1440

gtggtgagca acctgctgct gcctcagggc gtgctagccg tggagtgcga tttcagtcct     1500

ctgctgtcag ggaccccccc tcaggtgtac aacttcaagc ggctggtctt tactaactgt     1560

aactacaatc tgaccaagct gctgtcactg ttcagcgtga atgactttac atgctcccag     1620

atcagccccg cagccattgc tagtaactgt tactcctctc tgatcctgga ctacttctca     1680

tatccactga gtatgaagag cgacctgagc gtgagttcag ccggccccat cagccagttc     1740

aactataaac agagcttcag caatcctaca tgcctgattc tggctactgt gccacataat     1800

ctgactacca tcactaagcc cctgaaatac tcctatatta acaagtgcag ccggttcctg     1860

tccgacgata gaaccgaagt gccacagctg gtcaacgcca atcagtactc tccctgtgtg     1920

agtatcgtcc cttcaaccgt gtgggaagac ggggattact atagaaaaca gctgagcccc     1980

ctggagggag gaggatggct ggtggcatcc ggatctacag tcgccatgac tgagcagctg     2040

cagatggggt tcggaatcac agtgcagtac ggcacagaca ctaactctgt ctgtcccaag     2100

ctgtccggag agagccaggt gaggcagcag ttcagcaagg acatcgagaa gctgctgaac     2160

gagcaggtga acaaggagat gcagagcagc aacctgtaca tgagcatgag cagctggtgc     2220

tacacccaca gcctggacgg cgccggcctg ttcctgttcg accacgccgc cgaggagtac     2280

gagcacgcca agaagctgat catcttcctg aacgagaaca acgtgcccgt gcagctgacc     2340

agcatcagcg cccccgagca caagttcgag ggcctgaccc agatcttcca gaaggcctac     2400

gagcacgagc agcacatcag cgagagcatc aacaacatcg tggaccacgc catcaagagc     2460

aaggaccacg ccaccttcaa cttcctgcag tggtacgtgg ccgagcagca cgaggaggag     2520

gtgctgttca aggacatcct ggacaagatc gagctgatcg gcaacgagaa ccacggcctg     2580

tacctggccg accagtacgt gaagggcatc gccaagagca ggaagagcgg atcctagcat     2640

catcatcatc attagtctgg aagggcgaat tgatccagat ctgctgtgcc ttctagttgc     2700

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     2760

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     2820

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     2880

catgctgggg atgcggtggg ctctatgggt acccaggtgc tgaagaattg acccggttcc     2940

tcctgggcca gaaagaagca ggcacatccc cttctctgtg acacaccctg tccacgcccc     3000

tggttcttag ttccagcccc actcatagga cactcatagc tcaggagggc tccgccttca     3060

atcccacccg ctaaagtact tggagcggtc tctccctccc tcatcagccc accaaaccaa     3120

acctagcctc caagagtggg aagaaattaa agcaagatag gctattaagt gcagagggag     3180

agaaaatgcc tccaacatgt gaggaagtaa tgagagaaat catagaattt taaggccatg     3240

atttaaggcc atcatggcct taatcttccg cttcctcgct cactgactcg ctgcgctcgg     3300

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     3360

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     3420

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     3480

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     3540

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     3600

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     3660

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     3720

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     3780

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     3840

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta     3900

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     3960

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     4020

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct cagtggaacg     4080

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     4140

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     4200

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     4260

ccatagttgc ctgactcggg gggggggggc gctgaggtct gcctcgtgaa gaaggtgttg     4320

ctgactcata ccaggcctga atcgccccat catccagcca gaaagtgagg gagccacggt     4380

tgatgagagc tttgttgtag gtggaccagt tggtgatttt gaacttttgc tttgccacgg     4440

aacggtctgc gttgtcggga agatgcgtga tctgatcctt caactcagca aaagttcgat     4500

ttattcaaca aagccgccgt cccgtcaagt cagcgtaatg ctctgccagt gttacaacca     4560

attaaccaat tctgattaga aaaactcatc gagcatcaaa tgaaactgca atttattcat     4620

atcaggatta tcaataccat atttttgaaa aagccgtttc tgtaatgaag gagaaaactc     4680

accgaggcag ttccatagga tggcaagatc ctggtatcgg tctgcgattc cgactcgtcc     4740

aacatcaata caacctatta atttcccctc gtcaaaaata aggttatcaa gtgagaaatc     4800

accatgagtg acgactgaat ccggtgagaa tggcaaaagc ttatgcattt ctttccagac     4860

ttgttcaaca ggccagccat tacgctcgtc atcaaaatca ctcgcatcaa ccaaaccgtt     4920

attcattcgt gattgcgcct gagcgagacg aaatacgcga tcgctgttaa aaggacaatt     4980

acaaacagga atcgaatgca accggcgcag gaacactgcc agcgcatcaa caatattttc     5040

acctgaatca ggatattctt ctaatacctg gaatgctgtt ttcccgggga tcgcagtggt     5100

gagtaaccat gcatcatcag gagtacggat aaaatgcttg atggtcggaa gaggcataaa     5160

ttccgtcagc cagtttagtc tgaccatctc atctgtaaca tcattggcaa cgctaccttt     5220

gccatgtttc agaaacaact ctggcgcatc gggcttccca tacaatcgat agattgtcgc     5280

acctgattgc ccgacattat cgcgagccca tttataccca tataaatcag catccatgtt     5340

ggaatttaat cgcggcctcg agcaagacgt ttcccgttga atatggctca taacacccct     5400

tgtattactg tttatgtaag cagacagttt tattgttcat gatgatatat ttttatcttg     5460

tgcaatgtaa catcagagat tttgagacac aacgtggctt tccccccccc cccattattg     5520

aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta tttagaaaaa     5580

taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg tctaagaaac     5640

cattattatc atgacattaa cctataaaaa taggcgtatc acgaggccct ttcgtc         5696


<210>  28
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  28

Met Gln Ile Tyr Glu Gly Lys Leu Thr Ala Glu Gly Leu Arg Phe Gly 
1               5                   10                  15      


Ile Val Ala Ser Arg Phe Asn His Ala Leu Val Asp Arg Leu Val Glu 
            20                  25                  30          


Gly Ala Ile Asp Ala Ile Val Arg His Gly Gly Arg Glu Glu Asp Ile 
        35                  40                  45              


Thr Leu Val Arg Val Pro Gly Ser Trp Glu Ile Pro Val Ala Ala Gly 
    50                  55                  60                  


Glu Leu Ala Arg Lys Glu Asp Ile Asp Ala Val Ile Ala Ile Gly Val 
65                  70                  75                  80  


Leu Ile Arg Gly Ala Thr Pro His Phe Asp Tyr Ile Ala Ser Glu Val 
                85                  90                  95      


Ser Lys Gly Leu Ala Asp Leu Ser Leu Glu Leu Arg Lys Pro Ile Thr 
            100                 105                 110         


Phe Gly Val Ile Thr Ala Asp Thr Leu Glu Gln Ala Ile Glu Arg Ala 
        115                 120                 125             


Gly Thr Lys His Gly Asn Lys Gly Trp Glu Ala Ala Leu Ser Ala Ile 
    130                 135                 140                 


Glu Met Ala Asn Leu Phe Lys Ser Leu Arg 
145                 150                 


<210>  29
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  29

Met Glu Phe Leu Lys Arg Ser Phe Ala Pro Leu Thr Glu Lys Gln Trp 
1               5                   10                  15      


Gln Glu Ile Asp Asn Arg Ala Arg Glu Ile Phe Lys Thr Gln Leu Tyr 
            20                  25                  30          


Gly Arg Lys Phe Val Asp Val Glu Gly Pro Tyr Gly Trp Glu Tyr Ala 
        35                  40                  45              


Ala His Pro Leu Gly Glu Val Glu Val Leu Ser Asp Glu Asn Glu Val 
    50                  55                  60                  


Val Lys Trp Gly Leu Arg Lys Ser Leu Pro Leu Ile Glu Leu Arg Ala 
65                  70                  75                  80  


Thr Phe Thr Leu Asp Leu Trp Glu Leu Asp Asn Leu Glu Arg Gly Lys 
                85                  90                  95      


Pro Asn Val Asp Leu Ser Ser Leu Glu Glu Thr Val Arg Lys Val Ala 
            100                 105                 110         


Glu Phe Glu Asp Glu Val Ile Phe Arg Gly Cys Glu Lys Ser Gly Val 
        115                 120                 125             


Lys Gly Leu Leu Ser Phe Glu Glu Arg Lys Ile Glu Cys Gly Ser Thr 
    130                 135                 140                 


Pro Lys Asp Leu Leu Glu Ala Ile Val Arg Ala Leu Ser Ile Phe Ser 
145                 150                 155                 160 


Lys Asp Gly Ile Glu Gly Pro Tyr Thr Leu Val Ile Asn Thr Asp Arg 
                165                 170                 175     


Trp Ile Asn Phe Leu Lys Glu Glu Ala Gly His Tyr Pro Leu Glu Lys 
            180                 185                 190         


Arg Val Glu Glu Cys Leu Arg Gly Gly Lys Ile Ile Thr Thr Pro Arg 
        195                 200                 205             


Ile Glu Asp Ala Leu Val Val Ser Glu Arg Gly Gly Asp Phe Lys Leu 
    210                 215                 220                 


Ile Leu Gly Gln Asp Leu Ser Ile Gly Tyr Glu Asp Arg Glu Lys Asp 
225                 230                 235                 240 


Ala Val Arg Leu Phe Ile Thr Glu Thr Phe Thr Phe Gln Val Val Asn 
                245                 250                 255     


Pro Glu Ala Leu Ile Leu Leu Lys Phe 
            260                 265 


<210>  30
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  30

Met Glu Phe Leu Lys Arg Ser Phe Ala Pro Leu Thr Glu Lys Gln Trp 
1               5                   10                  15      


Gln Glu Ile Asp Asn Arg Ala Arg Glu Ile Phe Lys Thr Gln Leu Tyr 
            20                  25                  30          


Gly Arg Lys Phe Val Asp Val Glu Gly Pro Tyr Gly Trp Glu Tyr Ala 
        35                  40                  45              


Ala His Pro Leu Gly Glu Val Glu Val Leu Ser Asp Glu Asn Glu Val 
    50                  55                  60                  


Val Lys Trp Gly Leu Arg Lys Ser Leu Pro Leu Ile Glu Leu Arg Ala 
65                  70                  75                  80  


Thr Phe Thr Leu Asp Leu Trp Glu Leu Asp Asn Leu Glu Arg Gly Lys 
                85                  90                  95      


Pro Asn Val Asp Leu Ser Ser Leu Glu Glu Thr Val Arg Lys Val Ala 
            100                 105                 110         


Glu Phe Glu Asp Glu Val Ile Phe Arg Gly Cys Glu Lys Ser Gly Val 
        115                 120                 125             


Lys Gly Leu Leu Ser Phe Glu Glu Arg Lys Ile Glu Cys Gly Ser Thr 
    130                 135                 140                 


Pro Lys Asp Leu Leu Glu Ala Ile Val Arg Ala Leu Ser Ile Phe Ser 
145                 150                 155                 160 


Lys Asp Gly Ile Glu Gly Pro Tyr Thr Leu Val Ile Asn Thr Asp Arg 
                165                 170                 175     


Trp Ile Asn Phe Leu Lys Glu Glu Ala Gly His Tyr Pro Leu Glu Lys 
            180                 185                 190         


Arg Val Glu Glu Cys Leu Arg Gly Gly Lys Ile Ile Thr Thr Pro Arg 
        195                 200                 205             


Ile Glu Asp Ala Leu Val Val Ser Glu Arg Gly Gly Asp Phe Lys Leu 
    210                 215                 220                 


Ile Leu Gly Gln Asp Leu Ser Ile Gly Tyr Glu Asp Arg Glu Lys Asp 
225                 230                 235                 240 


Ala Val Arg Leu Phe Ile Thr Glu Thr Phe Thr Phe Gln Val Val Asn 
                245                 250                 255     


Pro Glu Ala Leu Ile Leu Leu Lys Ser Gly Glu Ala Lys Pro Ser Gly 
            260                 265                 270         


Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu 
        275                 280                 285             


Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe 
    290                 295                 300                 


Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val 
305                 310                 315                 320 


Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn 
                325                 330                 335     


Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met 
            340                 345                 350         


Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn 
        355                 360                 365             


Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val 
    370                 375                 380                 


Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile 
385                 390                 395                 400 


Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg Thr Glu Val Pro Gln 
                405                 410                 415     


Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser 
            420                 425                 430         


Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu 
        435                 440                 445             


Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr 
    450                 455                 460                 


Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp 
465                 470                 475                 480 


Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn Asp Thr Lys Ile 
                485                 490                 495     


Ala Ser Gln Leu Gly 
            500     


<210>  31
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  31

Met Glu Phe Leu Lys Arg Ser Phe Ala Pro Leu Thr Glu Lys Gln Trp 
1               5                   10                  15      


Gln Glu Ile Asp Asn Arg Ala Arg Glu Ile Phe Lys Thr Gln Leu Tyr 
            20                  25                  30          


Gly Arg Lys Phe Val Asp Val Glu Gly Pro Tyr Gly Trp Glu Tyr Ala 
        35                  40                  45              


Ala His Pro Leu Gly Glu Val Glu Val Leu Ser Asp Glu Asn Glu Val 
    50                  55                  60                  


Val Lys Trp Gly Leu Arg Lys Ser Leu Pro Leu Ile Glu Leu Arg Ala 
65                  70                  75                  80  


Thr Phe Thr Leu Asp Leu Trp Glu Leu Asp Asn Leu Glu Arg Gly Lys 
                85                  90                  95      


Pro Asn Val Asp Leu Ser Ser Leu Glu Glu Thr Val Arg Lys Val Ala 
            100                 105                 110         


Glu Phe Glu Asp Glu Val Ile Phe Arg Gly Cys Glu Lys Ser Gly Val 
        115                 120                 125             


Lys Gly Leu Leu Ser Phe Glu Glu Arg Lys Ile Glu Cys Gly Ser Thr 
    130                 135                 140                 


Pro Lys Asp Leu Leu Glu Ala Ile Val Arg Ala Leu Ser Ile Phe Ser 
145                 150                 155                 160 


Lys Asp Gly Ile Glu Gly Pro Tyr Thr Leu Val Ile Asn Thr Asp Arg 
                165                 170                 175     


Trp Ile Asn Phe Leu Lys Glu Glu Ala Gly His Tyr Pro Leu Glu Lys 
            180                 185                 190         


Arg Val Glu Glu Cys Leu Arg Gly Gly Lys Ile Ile Thr Thr Pro Arg 
        195                 200                 205             


Ile Glu Asp Ala Leu Val Val Ser Glu Arg Gly Gly Asp Phe Lys Leu 
    210                 215                 220                 


Ile Leu Gly Gln Asp Leu Ser Ile Gly Tyr Glu Asp Arg Glu Lys Asp 
225                 230                 235                 240 


Ala Val Arg Leu Phe Ile Thr Glu Thr Phe Thr Phe Gln Val Val Asn 
                245                 250                 255     


Pro Glu Ala Leu Ile Leu Leu Lys Ser Gly Val Glu Cys Asp Phe Ser 
            260                 265                 270         


Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu 
        275                 280                 285             


Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe 
    290                 295                 300                 


Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala 
305                 310                 315                 320 


Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu 
                325                 330                 335     


Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile Ser Gln 
            340                 345                 350         


Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala 
        355                 360                 365             


Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser 
    370                 375                 380                 


Tyr Ile Asn Lys Cys Ser Arg Phe Leu Ser Asp Asp Arg Thr Glu Val 
385                 390                 395                 400 


Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile Val 
                405                 410                 415     


Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser 
            420                 425                 430         


Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr Val Ala 
        435                 440                 445             


Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln Tyr Gly 
    450                 455                 460                 


Thr Asp Thr Asn Ser Val Cys Pro Lys Leu 
465                 470                 


<210>  32
<211>  6030
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  32
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

gggaacttcc atagcccata tatggagttc cgcgttacat aacttacggg aatttccaaa      420

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      480

gtaacgccaa tagggaactt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      540

cacttgggaa tttccaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg      600

ggaacttcca taagcttgca ttatgcccag tacatgacct tatgggaatt tcctacttgg      660

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      720

aatgggcgtg gatagcggtt tgactcacgg gaacttccaa gtctccaccc cattgacgtc      780

aatgggagtt tgttttgact caccaaaatc aacgggaatt cccaaaatgt cgtaacaact      840

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      900

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      960

gaagacaccg ggaccgatcc agcctccatc ggctcgcatc tctccttcac gcgcccgccg     1020

ccctacctga ggccgccatc cacgccggtt gagtcgcgtt ctgccgcctc ccgcctgtgg     1080

tgcctcctga actgcgtccg ccgtctaggt aagtttaaag ctcaggtcga gaccgggcct     1140

ttgtccggcg ctcccttgga gcctacctag actcagccgg ctctccacgc tttgcctgac     1200

cctgcttgct caactctagt taacggtgga gggcagtgta gtctgagcag tactcgttgc     1260

tgccgcgcgc gccaccagac ataatagctg acagactaac agactgttcc tttccatggg     1320

tcttttctgc agtcaccgtc gtcgacacgt gtgatcagat atcgcggccg ctctagacac     1380

catgcccatg ggcagcctgc agcccctggc caccctgtac ctgctgggca tgctggtggc     1440

tagcgtgctg gccatggagt tcctgaagag gagcttcgcc cctctgaccg agaagcagtg     1500

gcaggagatc gacaacaggg ccagggagat cttcaagacc cagctgtacg gcaggaagtt     1560

cgtggacgtg gagggcccct acggctggga gtacgccgcc caccccctgg gcgaggtgga     1620

ggtgctgagc gacgagaacg aggtggtgaa gtggggcctg aggaagagcc tgcccctgat     1680

cgagctgagg gccaccttca ccctggacct gtgggagctg gacaacctgg agaggggcaa     1740

gcccaacgtg gacctgagca gcctggagga gaccgtgagg aaggtggccg agttcgagga     1800

cgaggtgatc ttcaggggct gcgagaagag cggcgtgaag ggcctgctga gcttcgagga     1860

gaggaagatc gagtgcggca gcacccccaa ggacctgctg gaggccatcg tgagggccct     1920

gagcatcttc agcaaggacg gcatcgaggg cccctacacc ctggtgatca acaccgacag     1980

gtggatcaac ttcctgaagg aggaggccgg ccactacccc ctggagaaga gggtggagga     2040

gtgcctgagg ggcggcaaga tcatcaccac ccccaggatc gaggacgccc tggtggtgag     2100

cgagaggggc ggcgacttca agctgatcct gggccaggac ctgagcatcg gctacgagga     2160

cagggagaag gacgccgtga ggctgttcat caccgagacc ttcaccttcc aggtggtgaa     2220

ccccgaggcc ctgatcctgc tgaagtccgg agaggccaag ccctctggga gtgtggtcga     2280

gcaggctgaa ggagtggagt gcgatttcag tcctctgctg tcagggaccc cccctcaggt     2340

gtacaacttc aagcggctgg tctttactaa ctgtaactac aatctgacca agctgctgtc     2400

actgttcagc gtgaatgact ttacatgctc ccagatcagc cccgcagcca ttgctagtaa     2460

ctgttactcc tctctgatcc tggactactt ctcatatcca ctgagtatga agagcgacct     2520

gagcgtgagt tcagccggcc ccatcagcca gttcaactat aaacagagct tcagcaatcc     2580

tacatgcctg attctggcta ctgtgccaca taatctgact accatcacta agcccctgaa     2640

atactcctat attaacaagt gcagccggtt cctgtccgac gatagaaccg aagtgccaca     2700

gctggtcaac gccaatcagt actctccctg tgtgagtatc gtcccttcaa ccgtgtggga     2760

agacggggat tactatagaa aacagctgag ccccctggag ggaggaggat ggctggtggc     2820

atccggatct acagtcgcca tgactgagca gctgcagatg gggttcggaa tcacagtgca     2880

gtacggcaca gacactaact ctgtctgtcc caagctggaa ttcgctaacg atactaagat     2940

cgcaagtcag ctgggatgat gaggatccca tcatcatcat catcattagt ctggaagggc     3000

gaattgatcc agatctgctg tgccttctag ttgccagcca tctgttgttt gcccctcccc     3060

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga     3120

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga     3180

cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat     3240

gggtacccag gtgctgaaga attgacccgg ttcctcctgg gccagaaaga agcaggcaca     3300

tccccttctc tgtgacacac cctgtccacg cccctggttc ttagttccag ccccactcat     3360

aggacactca tagctcagga gggctccgcc ttcaatccca cccgctaaag tacttggagc     3420

ggtctctccc tccctcatca gcccaccaaa ccaaacctag cctccaagag tgggaagaaa     3480

ttaaagcaag ataggctatt aagtgcagag ggagagaaaa tgcctccaac atgtgaggaa     3540

gtaatgagag aaatcataga attttaaggc catgatttaa ggccatcatg gccttaatct     3600

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca     3660

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac     3720

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt     3780

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg     3840

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc     3900

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc     3960

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc     4020

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac     4080

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt     4140

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct     4200

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc     4260

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt     4320

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg     4380

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc     4440

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa     4500

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag     4560

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact cggggggggg     4620

gggcgctgag gtctgcctcg tgaagaaggt gttgctgact cataccaggc ctgaatcgcc     4680

ccatcatcca gccagaaagt gagggagcca cggttgatga gagctttgtt gtaggtggac     4740

cagttggtga ttttgaactt ttgctttgcc acggaacggt ctgcgttgtc gggaagatgc     4800

gtgatctgat ccttcaactc agcaaaagtt cgatttattc aacaaagccg ccgtcccgtc     4860

aagtcagcgt aatgctctgc cagtgttaca accaattaac caattctgat tagaaaaact     4920

catcgagcat caaatgaaac tgcaatttat tcatatcagg attatcaata ccatattttt     4980

gaaaaagccg tttctgtaat gaaggagaaa actcaccgag gcagttccat aggatggcaa     5040

gatcctggta tcggtctgcg attccgactc gtccaacatc aatacaacct attaatttcc     5100

cctcgtcaaa aataaggtta tcaagtgaga aatcaccatg agtgacgact gaatccggtg     5160

agaatggcaa aagcttatgc atttctttcc agacttgttc aacaggccag ccattacgct     5220

cgtcatcaaa atcactcgca tcaaccaaac cgttattcat tcgtgattgc gcctgagcga     5280

gacgaaatac gcgatcgctg ttaaaaggac aattacaaac aggaatcgaa tgcaaccggc     5340

gcaggaacac tgccagcgca tcaacaatat tttcacctga atcaggatat tcttctaata     5400

cctggaatgc tgttttcccg gggatcgcag tggtgagtaa ccatgcatca tcaggagtac     5460

ggataaaatg cttgatggtc ggaagaggca taaattccgt cagccagttt agtctgacca     5520

tctcatctgt aacatcattg gcaacgctac ctttgccatg tttcagaaac aactctggcg     5580

catcgggctt cccatacaat cgatagattg tcgcacctga ttgcccgaca ttatcgcgag     5640

cccatttata cccatataaa tcagcatcca tgttggaatt taatcgcggc ctcgagcaag     5700

acgtttcccg ttgaatatgg ctcataacac cccttgtatt actgtttatg taagcagaca     5760

gttttattgt tcatgatgat atatttttat cttgtgcaat gtaacatcag agattttgag     5820

acacaacgtg gctttccccc cccccccatt attgaagcat ttatcagggt tattgtctca     5880

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     5940

ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata     6000

aaaataggcg tatcacgagg ccctttcgtc                                      6030


<210>  33
<211>  5949
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  33
tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca       60

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg      120

ttggcgggtg tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc      180

accatatgcg gtgtgaaata ccgcacagat gcgtaaggag aaaataccgc atcagattgg      240

ctattggcca ttgcatacgt tgtatccata tcataatatg tacatttata ttggctcatg      300

tccaacatta ccgccatgtt gacattgatt attgactagt tattaatagt aatcaattac      360

gggaacttcc atagcccata tatggagttc cgcgttacat aacttacggg aatttccaaa      420

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      480

gtaacgccaa tagggaactt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      540

cacttgggaa tttccaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg      600

ggaacttcca taagcttgca ttatgcccag tacatgacct tatgggaatt tcctacttgg      660

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      720

aatgggcgtg gatagcggtt tgactcacgg gaacttccaa gtctccaccc cattgacgtc      780

aatgggagtt tgttttgact caccaaaatc aacgggaatt cccaaaatgt cgtaacaact      840

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag      900

ctcgtttagt gaaccgtcag atcgcctgga gacgccatcc acgctgtttt gacctccata      960

gaagacaccg ggaccgatcc agcctccatc ggctcgcatc tctccttcac gcgcccgccg     1020

ccctacctga ggccgccatc cacgccggtt gagtcgcgtt ctgccgcctc ccgcctgtgg     1080

tgcctcctga actgcgtccg ccgtctaggt aagtttaaag ctcaggtcga gaccgggcct     1140

ttgtccggcg ctcccttgga gcctacctag actcagccgg ctctccacgc tttgcctgac     1200

cctgcttgct caactctagt taacggtgga gggcagtgta gtctgagcag tactcgttgc     1260

tgccgcgcgc gccaccagac ataatagctg acagactaac agactgttcc tttccatggg     1320

tcttttctgc agtcaccgtc gtcgacacgt gtgatcagat atcgcggccg ctctagacac     1380

catgcccatg ggcagcctgc agcccctggc caccctgtac ctgctgggca tgctggtggc     1440

tagcgtgctg gccatggagt tcctgaagag gagcttcgcc cctctgaccg agaagcagtg     1500

gcaggagatc gacaacaggg ccagggagat cttcaagacc cagctgtacg gcaggaagtt     1560

cgtggacgtg gagggcccct acggctggga gtacgccgcc caccccctgg gcgaggtgga     1620

ggtgctgagc gacgagaacg aggtggtgaa gtggggcctg aggaagagcc tgcccctgat     1680

cgagctgagg gccaccttca ccctggacct gtgggagctg gacaacctgg agaggggcaa     1740

gcccaacgtg gacctgagca gcctggagga gaccgtgagg aaggtggccg agttcgagga     1800

cgaggtgatc ttcaggggct gcgagaagag cggcgtgaag ggcctgctga gcttcgagga     1860

gaggaagatc gagtgcggca gcacccccaa ggacctgctg gaggccatcg tgagggccct     1920

gagcatcttc agcaaggacg gcatcgaggg cccctacacc ctggtgatca acaccgacag     1980

gtggatcaac ttcctgaagg aggaggccgg ccactacccc ctggagaaga gggtggagga     2040

gtgcctgagg ggcggcaaga tcatcaccac ccccaggatc gaggacgccc tggtggtgag     2100

cgagaggggc ggcgacttca agctgatcct gggccaggac ctgagcatcg gctacgagga     2160

cagggagaag gacgccgtga ggctgttcat caccgagacc ttcaccttcc aggtggtgaa     2220

ccccgaggcc ctgatcctgc tgaagtccgg agtggagtgc gatttcagtc ctctgctgtc     2280

agggaccccc cctcaggtgt acaacttcaa gcggctggtc tttactaact gtaactacaa     2340

tctgaccaag ctgctgtcac tgttcagcgt gaatgacttt acatgctccc agatcagccc     2400

cgcagccatt gctagtaact gttactcctc tctgatcctg gactacttct catatccact     2460

gagtatgaag agcgacctga gcgtgagttc agccggcccc atcagccagt tcaactataa     2520

acagagcttc agcaatccta catgcctgat tctggctact gtgccacata atctgactac     2580

catcactaag cccctgaaat actcctatat taacaagtgc agccggttcc tgtccgacga     2640

tagaaccgaa gtgccacagc tggtcaacgc caatcagtac tctccctgtg tgagtatcgt     2700

cccttcaacc gtgtgggaag acggggatta ctatagaaaa cagctgagcc ccctggaggg     2760

aggaggatgg ctggtggcat ccggatctac agtcgccatg actgagcagc tgcagatggg     2820

gttcggaatc acagtgcagt acggcacaga cactaactct gtctgtccca agctgtgatg     2880

aggatcccat catcatcatc atcattagtc tggaagggcg aattgatcca gatctgctgt     2940

gccttctagt tgccagccat ctgttgtttg cccctccccc gtgccttcct tgaccctgga     3000

aggtgccact cccactgtcc tttcctaata aaatgaggaa attgcatcgc attgtctgag     3060

taggtgtcat tctattctgg ggggtggggt ggggcaggac agcaaggggg aggattggga     3120

agacaatagc aggcatgctg gggatgcggt gggctctatg ggtacccagg tgctgaagaa     3180

ttgacccggt tcctcctggg ccagaaagaa gcaggcacat ccccttctct gtgacacacc     3240

ctgtccacgc ccctggttct tagttccagc cccactcata ggacactcat agctcaggag     3300

ggctccgcct tcaatcccac ccgctaaagt acttggagcg gtctctccct ccctcatcag     3360

cccaccaaac caaacctagc ctccaagagt gggaagaaat taaagcaaga taggctatta     3420

agtgcagagg gagagaaaat gcctccaaca tgtgaggaag taatgagaga aatcatagaa     3480

ttttaaggcc atgatttaag gccatcatgg ccttaatctt ccgcttcctc gctcactgac     3540

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata     3600

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa     3660

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct     3720

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa     3780

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg     3840

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca     3900

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa     3960

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg     4020

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg     4080

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga     4140

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc     4200

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag     4260

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac     4320

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc     4380

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag     4440

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt     4500

ctatttcgtt catccatagt tgcctgactc gggggggggg ggcgctgagg tctgcctcgt     4560

gaagaaggtg ttgctgactc ataccaggcc tgaatcgccc catcatccag ccagaaagtg     4620

agggagccac ggttgatgag agctttgttg taggtggacc agttggtgat tttgaacttt     4680

tgctttgcca cggaacggtc tgcgttgtcg ggaagatgcg tgatctgatc cttcaactca     4740

gcaaaagttc gatttattca acaaagccgc cgtcccgtca agtcagcgta atgctctgcc     4800

agtgttacaa ccaattaacc aattctgatt agaaaaactc atcgagcatc aaatgaaact     4860

gcaatttatt catatcagga ttatcaatac catatttttg aaaaagccgt ttctgtaatg     4920

aaggagaaaa ctcaccgagg cagttccata ggatggcaag atcctggtat cggtctgcga     4980

ttccgactcg tccaacatca atacaaccta ttaatttccc ctcgtcaaaa ataaggttat     5040

caagtgagaa atcaccatga gtgacgactg aatccggtga gaatggcaaa agcttatgca     5100

tttctttcca gacttgttca acaggccagc cattacgctc gtcatcaaaa tcactcgcat     5160

caaccaaacc gttattcatt cgtgattgcg cctgagcgag acgaaatacg cgatcgctgt     5220

taaaaggaca attacaaaca ggaatcgaat gcaaccggcg caggaacact gccagcgcat     5280

caacaatatt ttcacctgaa tcaggatatt cttctaatac ctggaatgct gttttcccgg     5340

ggatcgcagt ggtgagtaac catgcatcat caggagtacg gataaaatgc ttgatggtcg     5400

gaagaggcat aaattccgtc agccagttta gtctgaccat ctcatctgta acatcattgg     5460

caacgctacc tttgccatgt ttcagaaaca actctggcgc atcgggcttc ccatacaatc     5520

gatagattgt cgcacctgat tgcccgacat tatcgcgagc ccatttatac ccatataaat     5580

cagcatccat gttggaattt aatcgcggcc tcgagcaaga cgtttcccgt tgaatatggc     5640

tcataacacc ccttgtatta ctgtttatgt aagcagacag ttttattgtt catgatgata     5700

tatttttatc ttgtgcaatg taacatcaga gattttgaga cacaacgtgg ctttcccccc     5760

ccccccatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     5820

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     5880

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     5940

cctttcgtc                                                             5949


<210>  34
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein nanoparticle sequence

<400>  34

Met Glu Phe Leu Lys Arg Ser Phe Ala Pro Leu Thr Glu Lys Gln Trp 
1               5                   10                  15      


Gln Glu Ile Asp Asn Arg Ala Arg Glu Ile Phe Lys Thr Gln Leu Tyr 
            20                  25                  30          


Gly Arg Lys Phe Val Asp Val Glu Gly Pro Tyr Gly Trp Glu Tyr Ala 
        35                  40                  45              


Ala His Pro Leu Gly Glu Val Glu Val Leu Ser Asp Glu Asn Glu Val 
    50                  55                  60                  


Val Lys Trp Gly Leu Arg Lys Ser Leu Pro Leu Ile Glu Leu Arg Ala 
65                  70                  75                  80  


Thr Phe Thr Leu Asp Leu Trp Glu Leu Asp Asn Leu Glu Arg Gly Lys 
                85                  90                  95      


Pro Asn Val Asp Leu Ser Ser Leu Glu Glu Thr Val Arg Lys Val Ala 
            100                 105                 110         


Glu Phe Glu Asp Glu Val Ile Phe Arg Gly Cys Glu Lys Ser Gly Val 
        115                 120                 125             


Lys Gly Leu Leu Ser Phe Glu Glu Arg Lys Ile Glu Cys Gly Ser Thr 
    130                 135                 140                 


Pro Lys Asp Leu Leu Glu Ala Ile Val Arg Ala Leu Ser Ile Phe Ser 
145                 150                 155                 160 


Lys Asp Gly Ile Glu Gly Pro Tyr Thr Leu Val Ile Asn Thr Asp Arg 
                165                 170                 175     


Trp Ile Asn Phe Leu Lys Glu Glu Ala Gly His Tyr Pro Leu Glu Lys 
            180                 185                 190         


Arg Val Glu Glu Cys Leu Arg Gly Gly Lys Ile Ile Thr Thr Pro Arg 
        195                 200                 205             


Ile Glu Asp Ala Leu Val Val Ser Glu Arg Gly Gly Asp Phe Lys Leu 
    210                 215                 220                 


Ile Leu Gly Gln Asp Leu Ser Ile Gly Tyr Glu Asp Arg Glu Lys Asp 
225                 230                 235                 240 


Ala Val Arg Leu Phe Ile Thr Glu Thr Phe Thr Phe Gln Val Val Asn 
                245                 250                 255     


Pro Glu Ala Leu Ile Leu Leu Lys Phe 
            260                 265 


<210>  35
<211>  381
<212>  DNA
<213>  Homo Sapiens

<400>  35
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc atctatgcta tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagagggg      300

ggccaccagg gatattgtag tggtggtagc tgctacgact ttgactactg gggccaggga      360

accctggtca ccgtctcctc a                                                381


<210>  36
<211>  127
<212>  PRT
<213>  Homo Sapiens

<400>  36

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ile Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Gly His Gln Gly Tyr Cys Ser Gly Gly Ser Cys Tyr 
            100                 105                 110         


Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  37
<211>  333
<212>  DNA
<213>  Homo Sapiens

<400>  37
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      240

agcagagtgg aggctgagga tgttggggtt tattattgca tgcaagctct acaaactcct      300

gcgttcggcg gagggaccaa gctggagatc aaa                                   333


<210>  38
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  38

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  39
<211>  378
<212>  DNA
<213>  Homo Sapiens

<400>  39
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcactg tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc      120

cagcccccag ggaaggggct ggagtggatt gggagtatct attatagtgg gagcacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccagttc      240

tccctgaagc tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgagcctc      300

ttaaggcccc tgatttattg tagtggtggt agctgcaccg actactgggg ccagggaacc      360

ctggtcaccg tctcctca                                                    378


<210>  40
<211>  126
<212>  PRT
<213>  Homo Sapiens

<400>  40

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ser Leu Leu Arg Pro Leu Ile Tyr Cys Ser Gly Gly Ser Cys 
            100                 105                 110         


Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  41
<211>  330
<212>  DNA
<213>  Homo Sapiens

<400>  41
cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc       60

tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtgccaacag      120

cacccaggca aagcccccaa actcatgatt tatgaggtca gtaatcggcc ctcaggggtt      180

tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg acgaggctga ttattactgc agctcatata caagcaacat cactcttgtc      300

ttcggaactg ggaccaaggt caccgtccta                                       330


<210>  42
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  42

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Cys Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Asn 
                85                  90                  95      


Ile Thr Leu Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  43
<211>  366
<212>  DNA
<213>  Homo Sapiens

<400>  43
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagtaggg      300

ttaggcagtg gctggtacga ctggttcgac ccctggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  44
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  44

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Gly Leu Gly Ser Gly Trp Tyr Asp Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  45
<211>  334
<212>  DNA
<213>  Homo Sapiens

<400>  45
cagtctgccc tgactcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc       60

tcctgcactg ggagcagctc caacatcggg gcaagttatg atgtacactg gtaccagcac      120

cttccaggaa cagcccccaa actcctcatc tatggtaaca ccaatcggcc ctcaggggtc      180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc      240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct gagtggtgtg      300

gtattcagcg gagggaccaa gctgaccgtc ctag                                  334


<210>  46
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  46

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Ser 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Thr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Ser Gly Val Val Phe Ser Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  47
<211>  366
<212>  DNA
<213>  Homo Sapiens

<400>  47
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc       60

tcctgcaagg cttctggagg caccttcagc acctatgctc tcagctgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaggg atcatcccta tctttggtac agcaaactac      180

gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgag cacggcctac      240

atggagttga acagcctgag atctgaggac acggccgtgt attactgtgc gagaggaagc      300

cggagcagct cttccgctga atacttccag cactggggcc agggcaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  48
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Arg Ser Ser Ser Ser Ala Glu Tyr Phe Gln His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  49
<211>  337
<212>  DNA
<213>  Homo Sapiens

<400>  49
cagtctgccc tgactcagcc tcgctcagtg tccgggtctc ctggacagtc agtcaccatc       60

tcctgcactg gaaccagcag tgatgttggt ggttataact atgtctcctg gtaccaacag      120

cacccaggca aagcccccaa actcatgatt tatgatgtca gtaagcggcc ctcaggggtc      180

cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc      240

caggctgagg atgaggctga ttattactgc tgctcatatg caggcagcta cactttagaa      300

gtggtattcg gcggagggac caagctgacc gtcctag                               337


<210>  50
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  50

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser 
                85                  90                  95      


Tyr Thr Leu Glu Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110         


<210>  51
<211>  354
<212>  DNA
<213>  Macaca Mulatta

<400>  51
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtctctc       60

acctgcgctg tttctggtgg ctccatcagc agcaactact ggtactggat ccgccagtcc      120

ccagtgaagg ggctggagtg gattgggtat atctatggtg gtagtggggg caccgaatac      180

aacccctccc tcaagagtcg agtcaccatt tcaacagaca cgtccaagaa ccagtttttc      240

ctgaagctga gctctgtgac cgccgcggac accgccgtat attactgtgc gagatccttt      300

tatagctgga acggggaatc ctggggccaa ggggtcgtcg tcaccgtctc ctca            354


<210>  52
<211>  118
<212>  PRT
<213>  Macaca Mulatta

<400>  52

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Trp Tyr Trp Ile Arg Gln Ser Pro Val Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Gly Gly Ser Gly Gly Thr Glu Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Thr Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Phe Tyr Ser Trp Asn Gly Glu Ser Trp Gly Gln Gly Val 
            100                 105                 110         


Val Val Thr Val Ser Ser 
        115             


<210>  53
<211>  321
<212>  DNA
<213>  Macaca Mulatta

<400>  53
gacattcaga tgtcccagac tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattaac gattatttaa attggtatca gcagaaaccg      120

gggaaagccc ctaagctcct gatctattat ggaaacagtt tggcaagtgg ggtcccatca      180

aggttcagtg gcagtggttc tgggacagat ttctctctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag ggtgatagtt tccctctcac tttcggcgga      300

gggaccaaag tggatatcaa a                                                321


<210>  54
<211>  107
<212>  PRT
<213>  Macaca Mulatta

<400>  54

Asp Ile Gln Met Ser Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asn Asp Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Gly Asn Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  55
<211>  363
<212>  DNA
<213>  Macaca Mulatta

<400>  55
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc       60

tcctgcaaag cttctggaca cattttcacc agttatgtta tcaactggct gcaagaggcc      120

cctggacaag ggtttgagtg gatgggagga atccaccctg gtaatggtgg cagagactac      180

gcacagaagt tccagggcag agtcacgatt accgcggaca tgtccacgag cacagtctac      240

atggagctga gaagtctgag atctgaggac atggccgtgt attactgtgc agcatccagt      300

ggtagttatg gtgttagctc attggatgtc tggggccggg gagttctggt caccgtctcc      360

tca                                                                    363


<210>  56
<211>  121
<212>  PRT
<213>  Macaca Mulatta

<400>  56

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly His Ile Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile Asn Trp Leu Gln Glu Ala Pro Gly Gln Gly Phe Glu Trp Met 
        35                  40                  45              


Gly Gly Ile His Pro Gly Asn Gly Gly Arg Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Met Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Met Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ser Gly Ser Tyr Gly Val Ser Ser Leu Asp Val Trp Gly 
            100                 105                 110         


Arg Gly Val Leu Val Thr Val Ser Ser 
        115                 120     


<210>  57
<211>  348
<212>  DNA
<213>  Macaca Mulatta

<400>  57
cagtctgccc tgactcagcc accctccctg tctgcatccc cgggagcatc ggccagactc       60

ccctgcaccc tgagcagtga cctcagtgtt ggtagtaaaa acatgtactg gtaccagcag      120

aagccaggga gcgctcccag gttattcctg tactactact ccgactcaga caagcagctg      180

ggacctgggg tccccaatcg agtctctggc tccaaggaga cctcaagtaa cacagcgttt      240

ttgctcatct ctgggctcca gcctgaggac gaggccgatt attactgtca ggtgtatgac      300

agtagtgcta attgggtatt cggcggaggg acccggctga cagtacta                   348


<210>  58
<211>  116
<212>  PRT
<213>  Macaca Mulatta

<400>  58

Gln Ser Ala Leu Thr Gln Pro Pro Ser Leu Ser Ala Ser Pro Gly Ala 
1               5                   10                  15      


Ser Ala Arg Leu Pro Cys Thr Leu Ser Ser Asp Leu Ser Val Gly Ser 
            20                  25                  30          


Lys Asn Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ala Pro Arg Leu 
        35                  40                  45              


Phe Leu Tyr Tyr Tyr Ser Asp Ser Asp Lys Gln Leu Gly Pro Gly Val 
    50                  55                  60                  


Pro Asn Arg Val Ser Gly Ser Lys Glu Thr Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Leu Leu Ile Ser Gly Leu Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Gln Val Tyr Asp Ser Ser Ala Asn Trp Val Phe Gly Gly Gly Thr Arg 
            100                 105                 110         


Leu Thr Val Leu 
        115     


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  59

Gly Gly Ser Ile Ser Ser Asn Tyr 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  60

Ile Tyr Gly Gly Ser Gly Ser Thr 
1               5               


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  61

Ala Arg Leu Leu Pro Leu Gly Gly Gly Tyr Cys Phe Asp Tyr 
1               5                   10                  


<210>  62
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  62

Gln Ser Leu Phe Asp Ser Asp Tyr Gly Asn Thr Tyr 
1               5                   10          


<210>  63
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  63

Met Leu Ser 
1           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  64

Met Gln Ser Val Glu Tyr Pro Phe Thr 
1               5                   


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  65

Gly Ser Ile Ser Asp Ser Tyr Arg 
1               5               


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  66

Ile Phe Ala Thr Gly Thr Thr Thr 
1               5               


<210>  67
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  67

Ala Arg Glu Pro Phe Lys Tyr Cys Ser Gly Gly Val Cys Tyr Ala His 
1               5                   10                  15      


Lys Asp Asn Ser Leu Asp Val 
            20              


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  68

Gln Ser Val Ser Ser Asn 
1               5       


<210>  69
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  69

Ser Ala Ser 
1           


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  70

Tyr Gln His Ser Ser Gly Tyr Thr 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  71

Gly Asp Ser Ile Ser Ser Asn Tyr 
1               5               


<210>  72
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  72

Phe Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  73

Ala Lys Thr Tyr Ser Gly Thr Phe Asp Tyr 
1               5                   10  


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  74

Gln Asp Ile Asn Asn Tyr 
1               5       


<210>  75
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  75

Tyr Ala Ser 
1           


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  76

Gln Gln Tyr Asn Asn Ser Pro Tyr Ser 
1               5                   


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  77

Gly Gly Thr Phe Ser Ile Tyr Ala 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  78

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  79
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  79

Ala Arg Glu Gly Gly His Gln Gly Tyr Cys Ser Gly Gly Ser Cys Tyr 
1               5                   10                  15      


Asp Phe Asp Tyr 
            20  


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  80

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  81
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  81

Leu Gly Ser 
1           


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  82

Met Gln Ala Leu Gln Thr Pro Ala 
1               5               


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  83

Gly Gly Ser Ile Ser Ser Ser Ser Tyr Tyr 
1               5                   10  


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  84

Ile Tyr Tyr Ser Gly Ser Thr 
1               5           


<210>  85
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  85

Ala Ser Leu Leu Arg Pro Leu Ile Tyr Cys Ser Gly Gly Ser Cys Thr 
1               5                   10                  15      


Asp Tyr 
        


<210>  86
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  86

Ser Ser Asp Val Gly Gly Tyr Asn Tyr 
1               5                   


<210>  87
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  87

Glu Val Ser 
1           


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  88

Ser Ser Tyr Thr Ser Asn Ile Thr Leu Val 
1               5                   10  


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  89

Gly Phe Thr Phe Ser Asp Tyr Tyr 
1               5               


<210>  90
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  90

Ile Ser Ser Ser Gly Ser Thr Ile 
1               5               


<210>  91
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  91

Ala Arg Val Gly Leu Gly Ser Gly Trp Tyr Asp Trp Phe Asp Pro 
1               5                   10                  15  


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  92

Ser Ser Asn Ile Gly Ala Ser Tyr Asp 
1               5                   


<210>  93
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  93

Gly Asn Thr 
1           


<210>  94
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  94

Gln Ser Tyr Asp Ser Ser Leu Ser Gly Val Val 
1               5                   10      


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  95

Gly Gly Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  96

Ala Arg Gly Ser Arg Ser Ser Ser Ser Ala Glu Tyr Phe Gln His 
1               5                   10                  15  


<210>  97
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  97

Asp Val Ser 
1           


<210>  98
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  98

Ser Tyr Ala Gly Ser Tyr Thr Leu Glu Val Val 
1               5                   10      


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  99

Ile Tyr Gly Gly Ser Gly Gly Thr 
1               5               


<210>  100
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  100

Ala Arg Ser Phe Tyr Ser Trp Asn Gly Glu Ser 
1               5                   10      


<210>  101
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  101

Gln Gly Ile Asn Asp Tyr 
1               5       


<210>  102
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  102

Tyr Gly Asn 
1           


<210>  103
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  103

Gln Gln Gly Asp Ser Phe Pro Leu Thr 
1               5                   


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  104

Gly His Ile Phe Thr Ser Tyr Val 
1               5               


<210>  105
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  105

Ile His Pro Gly Asn Gly Gly Arg 
1               5               


<210>  106
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  106

Ala Ala Ser Ser Gly Ser Tyr Gly Val Ser Ser Leu Asp Val 
1               5                   10                  


<210>  107
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  107

Ser Asp Leu Ser Val Gly Ser Lys Asn 
1               5                   


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  108

Tyr Tyr Ser Asp Ser Asp Lys 
1               5           


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  109

Gln Val Tyr Asp Ser Ser Ala Asn Trp Val 
1               5                   10  


<210>  110
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable region

<400>  110

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Ser Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  111
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody variable region

<400>  111

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Ala Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  112

Gln Ser Leu Leu His Ser Asn Ser Tyr Asn Tyr 
1               5                   10      


<210>  113
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  113

Gln Ser Leu Leu His Ser Asn Ala Tyr Asn Tyr 
1               5                   10      


<210>  114
<211>  360
<212>  DNA
<213>  Mus Musculus

<400>  114
cattcccagg tgcagctgca gcagtctgga ggtgagctgg tgaagcctgg ggcttcagtg       60

aagctgtcct gcaagacttc tggcttcacc ttcagcagta gctatataag ttggttgaag      120

caaaagcctg gacagagtct tgagtggatt gcatggattt atgctggaac tggtggtact      180

gaatataatc agaagttcac aggcaaggcc caagtgactg tagacacatc ctccagcaca      240

gcctacatgc aattcagcag cctgacaact gaggactctg ccatctatta ctgtgcaaga      300

ggaggtagta gcttcgctat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      360


<210>  115
<211>  118
<212>  PRT
<213>  Mus Musculus

<400>  115

Gln Val Gln Leu Gln Gln Ser Gly Gly Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Val Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ser Ser Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  116
<211>  333
<212>  DNA
<213>  Mus Musculus

<400>  116
caacttgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatccata ctgcatccaa ccaaggatcc      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctgtggagg acgatgatac tgcaatgtat ttctgtcagc aaagtgagga ggttcctctc      300

acgttcggtg ctgggaccaa gctggaaatc aaa                                   333


<210>  117
<211>  111
<212>  PRT
<213>  Mus Musculus

<400>  117

Gln Leu Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile His Thr Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Asp Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Glu 
                85                  90                  95      


Glu Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  118
<211>  366
<212>  DNA
<213>  Mus Musculus

<400>  118
caggtccagc tgcagcagtc tgggcctgag ctggtgaggc ctggggtctc agtgaagatt       60

tcctgcaagg gttccggcta cacattcact gattatgcta tacactgggt gaagcagagt      120

catgcaaaga gtctagagtg gattggggtt tttagtactt actatggtaa tacaaactac      180

aaccagaagt ttaagggcag ggccacaatg actgtagaca aatcctccag cacagcctat      240

atggaacttg ccagattgac atctgaggat tctgccatct attactgtgc aagaaagtcc      300

tactatgttg actacgttga tgctatggac tactggggtc aaggaacctc agtcaccgtc      360

tcctca                                                                 366


<210>  119
<211>  122
<212>  PRT
<213>  Mus Musculus

<400>  119

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Phe Ser Thr Tyr Tyr Gly Asn Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Ser Tyr Tyr Val Asp Tyr Val Asp Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  120
<211>  334
<212>  DNA
<213>  Mus Musculus

<400>  120
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca gagccagcga aagtgttgat aattatggca ttagttttat gaactggttc      120

caacagaaac caggacagcc acccaaactc ctcatctctg ctacatccaa ccaaggatcc      180

ggggtccctg ccaggtttat tggcagtggg tctgggacag acttcagcct caacatccat      240

cctgtggagg aggatgatac tgcaatgtat ttctgtcagc aaagtaagga ggttcctcgg      300

acgttcggtg gaggcaccaa gctggaaatc aaac                                  334


<210>  121
<211>  111
<212>  PRT
<213>  Mus Musculus

<400>  121

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Ser Ala Thr Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  122
<211>  350
<212>  DNA
<213>  Mus Musculus

<400>  122
gaggtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagact      120

ccggagaaga ggctggagtg ggtcgcaacc attagtagtg gtggtactta cacctactat      180

ccagacagtg tgaaggggcg attcaccatc tccagagaca atgccgagaa caccctgtac      240

ctgcaaatga gcagtctgag gtctgaggac acggccatgt attactgtgt aagagatggt      300

aattctatgg actactgggg tcaaggaacc tcagtcaccg tctcctcagc                 350


<210>  123
<211>  116
<212>  PRT
<213>  Mus Musculus

<400>  123

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Gly Asn Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  124
<211>  321
<212>  DNA
<213>  Mus Musculus

<400>  124
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcatttgca gggcaagtca ggacattaac aattatttaa actggtatca acagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggatcagat tattctctca ccattagcaa cctggaacaa      240

gaagatattg ccacttactt ttgccaacag gctaatacgc ttcctcccac gttcggtgct      300

gggaccaagc tggaactgag a                                                321


<210>  125
<211>  107
<212>  PRT
<213>  Mus Musculus

<400>  125

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ile Cys Arg Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Ala Asn Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg 
            100                 105         


<210>  126
<211>  374
<212>  DNA
<213>  Mus Musculus

<400>  126
cattccgagg tgaagctgga ggagtctggg ggaggcttag tgaagcctgg agggtccctg       60

aaactctcct gtgcagcctc tggattcact ttcagtaggt atgccatgtc ttgggttcgc      120

cagactccgg agaagaggct ggagtgggtc gcaaccatta ataatggtgg tagttacagt      180

tactatccag acagtgtgaa gggtcgactc accatctcca gagacaatgc caagaacacc      240

ctgtacctgc aaatgagcag tctgaggtct gaggacacgg ccttgtatta ctgtgcaaga      300

cactatgatt acgacggata ttactatact atggacttct ggggtcaagg aacctcagtc      360

accgtctcct cagc                                                        374


<210>  127
<211>  122
<212>  PRT
<213>  Mus Musculus

<400>  127

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Asn Asn Gly Gly Ser Tyr Ser Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Asp Tyr Asp Gly Tyr Tyr Tyr Thr Met Asp Phe Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  128
<211>  338
<212>  DNA
<213>  Mus Musculus

<400>  128
gatgttttga tgacccaaat tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atttcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag cccctgatct acaaagtttc caaccgaatt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttccg      300

tacacgttcg gaggggggac caacctggaa ataaaacg                              338


<210>  129
<211>  113
<212>  PRT
<213>  Mus Musculus

<400>  129

Asp Val Leu Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Pro Leu Ile Tyr Lys Val Ser Asn Arg Ile Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  130
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  130

Gly Phe Thr Phe Ser Ser Ser Tyr 
1               5               


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  131

Ile Tyr Ala Gly Thr Gly Gly Thr 
1               5               


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  132

Ala Arg Gly Gly Ser Ser Phe Ala Met Asp Tyr 
1               5                   10      


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  133

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  134
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  134

Thr Ala Ser 
1           


<210>  135
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  135

Gln Gln Ser Glu Glu 
1               5   


<210>  136
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  136

Gly Tyr Thr Phe Thr Asp Tyr Ala 
1               5               


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  137

Phe Ser Thr Tyr Tyr Gly Asn Thr 
1               5               


<210>  138
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  138

Ala Arg Lys Ser Tyr Tyr Val Asp Tyr Val Asp Ala Met Asp Tyr 
1               5                   10                  15  


<210>  139
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  139

Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe 
1               5                   10  


<210>  140
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  140

Ala Thr Ser 
1           


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  141

Gln Gln Ser Lys Glu Val Pro Arg Thr 
1               5                   


<210>  142
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  142

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  143
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  143

Ile Ser Ser Gly Gly Thr Tyr Thr 
1               5               


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  144

Val Arg Asp Gly Asn Ser Met Asp Tyr 
1               5                   


<210>  145
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  145

Tyr Thr Ser 
1           


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  146

Gln Gln Ala Asn Thr Leu Pro Pro Thr 
1               5                   


<210>  147
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  147

Gly Phe Thr Phe Ser Arg Tyr Ala 
1               5               


<210>  148
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  148

Ile Asn Asn Gly Gly Ser Tyr Ser 
1               5               


<210>  149
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  149

Ala Arg His Tyr Asp Tyr Asp Gly Tyr Tyr Tyr Thr Met Asp Phe 
1               5                   10                  15  


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  150

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  151
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  151

Lys Val Ser 
1           


<210>  152
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody CDR

<400>  152

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  153
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody heavy chain

<400>  153
atgggatggt catgtatcat cctttttcta gtagcaactg caaccggtgt acattcccag       60

gtgcagctgc agcagtctgg aggtgagctg gtgaagcctg gggcttcagt gaagctgtcc      120

tgcaagactt ctggcttcac cttcagcagt agctatataa gttggttgaa gcaaaagcct      180

ggacagagtc ttgagtggat tgcatggatt tatgctggaa ctggtggtac tgaatataat      240

cagaagttca caggcaaggc ccaagtgact gtagacacat cctccagcac agcctacatg      300

caattcagca gcctgacaac tgaggactct gccatctatt actgtgcaag aggaggtagt      360

agcttcgcta tggactactg gggtcaagga acctcagtca ccgtctcctc agcgtcgacc      420

acgcccccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      480

gccctgggct gcctggtcaa ggactacttc cccgaacccg tgacggtgtc gtggaactca      540

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      600

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      660

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      720

gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      780

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      840

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     1320

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1380

ctctccctgt ctccgggtaa atga                                            1404


<210>  154
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody heavy chain

<400>  154

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Gly Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Ser Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu 
    50                  55                  60                  


Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Glu Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Thr Gly Lys Ala Gln Val Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Phe Ser Ser Leu Thr Thr Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Gly Ser Ser Phe Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
145                 150                 155                 160 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
        195                 200                 205             


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
    210                 215                 220                 


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


