                         SEQUENCE LISTING

<110>  Lim, Wendell A.
       Morsut, Leonardo
       Roybal, Kole T.
 
<120>  BINDING-TRIGGERED TRANSCRIPTIONAL SWITCHES AND METHODS OF USE 
       THEREOF

<130>  UCSF-511WO

<150>  US 62/120,256
<151>  2015-02-24

<150>  US 62/257,153
<151>  2015-11-18

<150>  US 62/269,758
<151>  2015-12-18

<160>  210   

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
1               5                   10                  15      


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
            20                  25                  30          


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40                  45              


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
    50                  55                  60                  


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
65                  70                  75                  80  


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
                85                  90                  95      


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
            100                 105                 110         


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
        115                 120                 125             


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
    130                 135                 140                 


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
145                 150                 155                 160 


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
                165                 170                 175     


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
            180                 185                 190         


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
        195                 200                 205             


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
    210                 215                 220                 


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
225                 230                 235                 240 


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
                245                 250                 255     


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
            260                 265                 270         


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
        275                 280                 285             


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
    290                 295                 300                 


Leu Ser 
305     


<210>  2
<211>  358
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro 
1               5                   10                  15      


Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn 
            20                  25                  30          


Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly 
        35                  40                  45              


Arg Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu 
    50                  55                  60                  


Cys Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn 
65                  70                  75                  80  


His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp 
                85                  90                  95      


Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser 
            100                 105                 110         


Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp 
        115                 120                 125             


Gly Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp 
    130                 135                 140                 


Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys 
145                 150                 155                 160 


Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val 
                165                 170                 175     


Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro 
            180                 185                 190         


Pro Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser 
        195                 200                 205             


His Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln 
    210                 215                 220                 


Gln Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His 
225                 230                 235                 240 


Pro Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro 
                245                 250                 255     


Gly Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile 
            260                 265                 270         


Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln 
        275                 280                 285             


Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu 
    290                 295                 300                 


Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu 
305                 310                 315                 320 


Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His 
                325                 330                 335     


Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
            340                 345                 350         


Cys Gly Val Leu Leu Ser 
        355             


<210>  3
<211>  134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Gly Val Leu Ser Ser Pro Cys Pro Pro Asn Trp Ile Ile Tyr Glu Lys 
1               5                   10                  15      


Ser Cys Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp Gly Ser Lys 
            20                  25                  30          


Arg Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile Asp Ser Ser 
        35                  40                  45              


Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser Gln Pro Asp Asn 
    50                  55                  60                  


Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Thr Glu Val Pro Trp Leu 
65                  70                  75                  80  


Trp Glu Asp Gly Ser Thr Phe Ser Ser Asn Leu Phe Gln Ile Arg Thr 
                85                  90                  95      


Thr Ala Thr Gln Glu Asn Pro Ser Pro Asn Cys Val Trp Ile His Val 
            100                 105                 110         


Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Pro Ser Tyr Ser Ile Cys 
        115                 120                 125             


Glu Lys Lys Phe Ser Met 
    130                 


<210>  4
<211>  56
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro Val Glu Pro Pro 
1               5                   10                  15      


Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala Ala Ala Phe Val 
            20                  25                  30          


Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg 
        35                  40                  45              


Arg Gln Leu Cys Ile Gln Lys Leu 
    50                  55      


<210>  5
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
1               5                   10                  15      


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
            20                  25                  30          


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
        35                  40                  45              


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
    50                  55                  60                  


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
65                  70                  75                  80  


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
                85                  90                  95      


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
            100                 105                 110         


Cys Glu Trp Asp Gly Leu Asp Cys 
        115                 120 


<210>  6
<211>  152
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
1               5                   10                  15      


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
            20                  25                  30          


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
        35                  40                  45              


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
    50                  55                  60                  


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
65                  70                  75                  80  


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
                85                  90                  95      


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
            100                 105                 110         


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
        115                 120                 125             


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
    130                 135                 140                 


Glu Pro Val Glu Pro Pro Leu Pro 
145                 150         


<210>  7
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  7

His Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
1               5                   10                  15      


Gly Cys Gly Val Leu Leu Ser 
            20              


<210>  8
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro 
1               5                   10                  15      


Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn 
            20                  25                  30          


Gly Leu Leu Cys His 
        35          


<210>  9
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His Gly Ala Ser Cys 
1               5                   10                  15      


Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln Ala Gly Tyr Ser 
            20                  25                  30          


Gly Arg Asn Cys Glu 
        35          


<210>  10
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Asp Ile Asp Asp Cys Arg Pro Asn Pro Cys His Asn Gly Gly Ser Cys 
1               5                   10                  15      


Thr Asp Gly Ile Asn Thr Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg 
            20                  25                  30          


Gly Thr Phe Cys Glu 
        35          


<210>  11
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
1               5                   10                  15      


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
            20                  25                  30          


Gly Ile His Cys Glu 
        35          


<210>  12
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Thr Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn 
1               5                   10                  15      


Ser Phe Thr Cys Leu Cys Pro Pro Gly Phe Thr Gly Ser Tyr Cys Gln 
            20                  25                  30          


<210>  13
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Asp Val Asn Glu Cys Asp Ser Gln Pro Cys Leu His Gly Gly Thr Cys 
1               5                   10                  15      


Gln Asp Gly Cys Gly Ser Tyr Arg Cys Thr Cys Pro Gln Gly Tyr Thr 
            20                  25                  30          


Gly Pro Asn Cys Gln 
        35          


<210>  14
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Asp Ser Ser Pro Cys Lys Asn Gly Gly Lys Cys Trp Gln Thr His Thr 
1               5                   10                  15      


Gln Tyr Arg Cys Glu Cys Pro Ser Gly Trp Thr 
            20                  25          


<210>  15
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Leu Val Asp Glu Cys Ser Pro Ser Pro Cys Gln Asn Gly Ala Thr Cys 
1               5                   10                  15      


Thr Asp Tyr Leu Gly Gly Tyr Ser Cys Lys Cys Val Ala Gly Tyr His 
            20                  25                  30          


Gly Val Asn Cys 
        35      


<210>  16
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Ile Asp Glu Cys Leu Ser His Pro Cys Gln Asn Gly Gly Thr Cys Leu 
1               5                   10                  15      


Asp Leu Pro Asn Thr Tyr Lys Cys Ser Cys Pro Arg Gly Thr Gln Gly 
            20                  25                  30          


Val His Cys Glu 
        35      


<210>  17
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Cys Phe Asn Asn Gly Thr Cys Val Asp Gln Val Gly Gly Tyr Ser Cys 
1               5                   10                  15      


Thr Cys Pro Pro Gly Phe Val Gly Glu Arg Cys Glu 
            20                  25              


<210>  18
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Asp Val Asn Glu Cys Leu Ser Asn Pro Cys Asp Ala Arg Gly Thr Gln 
1               5                   10                  15      


Asn Cys Val Gln Arg Val Asn Asp Phe His Cys Glu Cys Arg Ala Gly 
            20                  25                  30          


His Thr Gly Arg Arg Cys Glu 
        35                  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Gly Arg Arg Arg Arg Glu Leu Asp Pro Met 
1               5                   10  


<210>  20
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Arg Gln Arg Arg Glu Leu Asp Pro Met 
1               5                   


<210>  21
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Lys Ile Glu Ala Val Lys Ser Glu 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  22

Lys Ile Glu Ala Val Gln Ser Glu 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Val Gly Cys Gly Val Leu Leu Ser 
1               5               


<210>  24
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  24

Gly Cys Gly Val Leu Leu Ser 
1               5           


<210>  25
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser 
1               5                   10                  15      


Asp Leu Asn Thr Gln 
            20      


<210>  26
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  26

Asp Gly Val Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu 
1               5                   10                  15      


Thr Leu Lys His Glu 
            20      


<210>  27
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  27

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  28
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
1               5                   10                  15      


Val Leu Asp Lys Arg 
            20      


<210>  29
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
1               5                   10                  15      


Ser Glu Ile Gly Met Lys 
            20          


<210>  30
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
1               5                   10                  15      


Ala Leu His Met Gln 
            20      


<210>  31
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  32
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Thr Arg Lys 
65                  70                  75                  80  


Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln 
                85                  90                  95      


Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
            100                 105                 110         


<210>  33
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr 
65                  70                  75                  80  


Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr 
                85                  90                  95      


Gln Arg Pro Tyr Tyr Lys 
            100         


<210>  34
<211>  101
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Asp Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu 
            20                  25                  30          


Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu 
        35                  40                  45              


Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala 
    50                  55                  60                  


Glu Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln 
65                  70                  75                  80  


Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln 
                85                  90                  95      


Arg Pro Tyr Tyr Lys 
            100     


<210>  35
<211>  86
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  36
<211>  171
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  37
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  38
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr Ser 
1               5                   10                  15      


His Leu Gly Gly Asn 
            20      


<210>  39
<211>  207
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  40
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
1               5                   10                  15      


Gly Leu Asn Gln Arg 
            20      


<210>  41
<211>  182
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  42
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser 
1               5                   10                  15      


His Leu Gln Gly Asn 
            20      


<210>  43
<211>  163
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  44
<211>  164
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  45
<211>  226
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Gly Thr Leu Ile Ile Gln Asn Val 
                85                  90                  95      


Asn Lys Ser His Gly Gly Ile Tyr Val Cys Arg Val Gln Glu Gly Asn 
            100                 105                 110         


Glu Ser Tyr Gln Gln Ser Cys Gly Thr Tyr Leu Arg Val Arg Gln Pro 
        115                 120                 125             


Pro Pro Arg Pro Phe Leu Asp Met Gly Glu Gly Thr Lys Asn Arg Ile 
    130                 135                 140                 


Ile Thr Ala Glu Gly Ile Ile Leu Leu Phe Cys Ala Val Val Pro Gly 
145                 150                 155                 160 


Thr Leu Leu Leu Phe Arg Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu 
                165                 170                 175     


Asp Ala Gly Asp Glu Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn 
            180                 185                 190         


Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly 
        195                 200                 205             


Thr Tyr Gln Asp Val Gly Ser Leu Asn Ile Gly Asp Val Gln Leu Glu 
    210                 215                 220                 


Lys Pro 
225     


<210>  46
<211>  188
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Met Pro Gly Gly Pro Gly Val Leu Gln Ala Leu Pro Ala Thr Ile Phe 
1               5                   10                  15      


Leu Leu Phe Leu Leu Ser Ala Val Tyr Leu Gly Pro Gly Cys Gln Ala 
            20                  25                  30          


Leu Trp Met His Lys Val Pro Ala Ser Leu Met Val Ser Leu Gly Glu 
        35                  40                  45              


Asp Ala His Phe Gln Cys Pro His Asn Ser Ser Asn Asn Ala Asn Val 
    50                  55                  60                  


Thr Trp Trp Arg Val Leu His Gly Asn Tyr Thr Trp Pro Pro Glu Phe 
65                  70                  75                  80  


Leu Gly Pro Gly Glu Asp Pro Asn Glu Pro Pro Pro Arg Pro Phe Leu 
                85                  90                  95      


Asp Met Gly Glu Gly Thr Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile 
            100                 105                 110         


Ile Leu Leu Phe Cys Ala Val Val Pro Gly Thr Leu Leu Leu Phe Arg 
        115                 120                 125             


Lys Arg Trp Gln Asn Glu Lys Leu Gly Leu Asp Ala Gly Asp Glu Tyr 
    130                 135                 140                 


Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met 
145                 150                 155                 160 


Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val Gly 
                165                 170                 175     


Ser Leu Asn Ile Gly Asp Val Gln Leu Glu Lys Pro 
            180                 185             


<210>  47
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met Tyr Glu 
1               5                   10                  15      


Asp Ile Ser Arg Gly 
            20      


<210>  48
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Arg Pro Arg Arg Ser Pro Ala Gln Asp Gly Lys Val Tyr Ile Asn Met 
1               5                   10                  15      


Pro Gly Arg Gly 
            20  


<210>  49
<211>  68
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  50
<211>  619
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  51
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
1               5                   10                  15      


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            20                  25                  30          


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40                  


<210>  52
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  53
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
1               5                   10                  15      


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            20                  25                  30          


Thr Leu Ala Lys Ile 
        35          


<210>  54
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr 
1               5                   10                  15      


Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln 
            20                  25                  30          


Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr 
        35                  40                  45              


Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly 
    50                  55                  60                  


Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile 
65                  70                  75                  80  


Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu 
                85                  90                  95      


Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val 
            100                 105                 110         


Arg Ser 
        


<210>  55
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  55

His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu 
1               5                   10                  15      


Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser 
            20                  25                  30          


Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser 
        35                  40                  45              


Pro 
    


<210>  56
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Arg Arg Ala Cys Arg Lys Arg Ile Arg Gln Lys Leu His Leu Cys Tyr 
1               5                   10                  15      


Pro Val Gln Thr Ser Gln Pro Lys Leu Glu Leu Val Asp Ser Arg Pro 
            20                  25                  30          


Arg Arg Ser Ser Thr Gln Leu Arg Ser Gly Ala Ser Val Thr Glu Pro 
        35                  40                  45              


Val Ala Glu Glu Arg Gly Leu Met Ser Gln Pro Leu Met Glu Thr Cys 
    50                  55                  60                  


His Ser Val Gly Ala Ala Tyr Leu Glu Ser Leu Pro Leu Gln Asp Ala 
65                  70                  75                  80  


Ser Pro Ala Gly Gly Pro Ser Ser Pro Arg Asp Leu Pro Glu Pro Arg 
                85                  90                  95      


Val Ser Thr Glu His Thr Asn Asn Lys Ile Glu Lys Ile Tyr Ile Met 
            100                 105                 110         


Lys Ala Asp Thr Val Ile Val Gly Thr Val Lys Ala Glu Leu Pro Glu 
        115                 120                 125             


Gly Arg Gly Leu Ala Gly Pro Ala Glu Pro Glu Leu Glu Glu Glu Leu 
    130                 135                 140                 


Glu Ala Asp His Thr Pro His Tyr Pro Glu Gln Glu Thr Glu Pro Pro 
145                 150                 155                 160 


Leu Gly Ser Cys Ser Asp Val Met Leu Ser Val Glu Glu Glu Gly Lys 
                165                 170                 175     


Glu Asp Pro Leu Pro Thr Ala Ala Ser Gly Lys 
            180                 185         


<210>  57
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  57

His Ile Trp Gln Leu Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln 
1               5                   10                  15      


Leu Leu Leu Glu Val Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln 
            20                  25                  30          


Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg 
        35                  40                  45              


Leu Gly Asp Leu Trp Val 
    50                  


<210>  58
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Cys Val Lys Arg Arg Lys Pro Arg Gly Asp Val Val Lys Val Ile Val 
1               5                   10                  15      


Ser Val Gln Arg Lys Arg Gln Glu Ala Glu Gly Glu Ala Thr Val Ile 
            20                  25                  30          


Glu Ala Leu Gln Ala Pro Pro Asp Val Thr Thr Val Ala Val Glu Glu 
        35                  40                  45              


Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro Asn His 
    50                  55                  60  


<210>  59
<211>  169
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
    50                  55                  60                  


Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
65                  70                  75                  80  


Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val 
                85                  90                  95      


Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
            100                 105                 110         


Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala 
        115                 120                 125             


Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
    130                 135                 140                 


Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg 
145                 150                 155                 160 


Pro Ala Gly Gln Phe Gln Thr Leu Val 
                165                 


<210>  60
<211>  223
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  61
<211>  181
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Met Leu Leu Glu Pro Gly Arg Gly Cys Cys Ala Leu Ala Ile Leu Leu 
1               5                   10                  15      


Ala Ile Val Asp Ile Gln Ser Gly Gly Cys Ile Asn Ile Thr Ser Ser 
            20                  25                  30          


Ala Ser Gln Glu Gly Thr Arg Leu Asn Leu Ile Cys Thr Val Trp His 
        35                  40                  45              


Lys Lys Glu Glu Ala Glu Gly Phe Val Val Phe Leu Cys Lys Asp Arg 
    50                  55                  60                  


Ser Gly Asp Cys Ser Pro Glu Thr Ser Leu Lys Gln Leu Arg Leu Lys 
65                  70                  75                  80  


Arg Asp Pro Gly Ile Asp Gly Val Gly Glu Ile Ser Ser Gln Leu Met 
                85                  90                  95      


Phe Thr Ile Ser Gln Val Thr Pro Leu His Ser Gly Thr Tyr Gln Cys 
            100                 105                 110         


Cys Ala Arg Ser Gln Lys Ser Gly Ile Arg Leu Gln Gly His Phe Phe 
        115                 120                 125             


Ser Ile Leu Phe Thr Glu Thr Gly Asn Tyr Thr Val Thr Gly Leu Lys 
    130                 135                 140                 


Gln Arg Gln His Leu Glu Phe Ser His Asn Glu Gly Thr Leu Ser Ser 
145                 150                 155                 160 


Gly Phe Leu Gln Glu Lys Val Trp Val Met Leu Val Thr Ser Leu Val 
                165                 170                 175     


Ala Leu Gln Ala Leu 
            180     


<210>  62
<211>  301
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Met Phe Ser His Leu Pro Phe Asp Cys Val Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Thr Arg Ser Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu 
        35                  40                  45              


Val Pro Val Cys Trp Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly 
    50                  55                  60                  


Asn Val Val Leu Arg Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser 
65                  70                  75                  80  


Arg Tyr Trp Leu Asn Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr 
                85                  90                  95      


Ile Glu Asn Val Thr Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile 
            100                 105                 110         


Gln Ile Pro Gly Ile Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val 
        115                 120                 125             


Ile Lys Pro Ala Lys Val Thr Pro Ala Pro Thr Leu Gln Arg Asp Phe 
    130                 135                 140                 


Thr Ala Ala Phe Pro Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile 
                165                 170                 175     


Ser Thr Leu Ala Asn Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu 
            180                 185                 190         


Arg Asp Ser Gly Ala Thr Ile Arg Ile Gly Ile Tyr Ile Gly Ala Gly 
        195                 200                 205             


Ile Cys Ala Gly Leu Ala Leu Ala Leu Ile Phe Gly Ala Leu Ile Phe 
    210                 215                 220                 


Lys Trp Tyr Ser His Ser Lys Glu Lys Ile Gln Asn Leu Ser Leu Ile 
225                 230                 235                 240 


Ser Leu Ala Asn Leu Pro Pro Ser Gly Leu Ala Asn Ala Val Ala Glu 
                245                 250                 255     


Gly Ile Arg Ser Glu Glu Asn Ile Tyr Thr Ile Glu Glu Asn Val Tyr 
            260                 265                 270         


Glu Val Glu Glu Pro Asn Glu Tyr Tyr Cys Tyr Val Ser Ser Arg Gln 
        275                 280                 285             


Gln Pro Ser Gln Pro Leu Gly Cys Arg Phe Ala Met Pro 
    290                 295                 300     


<210>  63
<211>  525
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Met Trp Glu Ala Gln Phe Leu Gly Leu Leu Phe Leu Gln Pro Leu Trp 
1               5                   10                  15      


Val Ala Pro Val Lys Pro Leu Gln Pro Gly Ala Glu Val Pro Val Val 
            20                  25                  30          


Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys Ser Pro Thr Ile 
        35                  40                  45              


Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly Val Thr Trp Gln 
    50                  55                  60                  


His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro Gly His Pro Leu 
65                  70                  75                  80  


Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp Gly Pro Arg Pro 
                85                  90                  95      


Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly Leu Arg Ser Gly 
            100                 105                 110         


Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu Arg Gly Arg Gln 
        115                 120                 125             


Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg Arg Ala Asp Ala 
    130                 135                 140                 


Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg Ala Leu Ser Cys 
145                 150                 155                 160 


Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr Ala Ser Pro Pro 
                165                 170                 175     


Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn Cys Ser Phe Ser 
            180                 185                 190         


Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg Asn Arg Gly Gln 
        195                 200                 205             


Gly Arg Val Pro Val Arg Glu Ser Pro His His His Leu Ala Glu Ser 
    210                 215                 220                 


Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser Gly Pro Trp Gly 
225                 230                 235                 240 


Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser Ile Met Tyr Asn 
                245                 250                 255     


Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu Thr Val Tyr Ala 
            260                 265                 270         


Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu Pro Ala Gly Val 
        275                 280                 285             


Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro Pro Gly Gly Gly 
    290                 295                 300                 


Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe Thr Leu Arg Leu 
305                 310                 315                 320 


Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr Cys His Ile His 
                325                 330                 335     


Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu Ala Ile Ile Thr 
            340                 345                 350         


Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu Gly Lys Leu Leu 
        355                 360                 365             


Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe Val Trp Ser Ser 
    370                 375                 380                 


Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro Trp Leu Glu Ala 
385                 390                 395                 400 


Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys Gln Leu Tyr Gln 
                405                 410                 415     


Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr Glu Leu Ser Ser 
            420                 425                 430         


Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala Leu Pro Ala Gly 
        435                 440                 445             


His Leu Leu Leu Phe Leu Ile Leu Gly Val Leu Ser Leu Leu Leu Leu 
    450                 455                 460                 


Val Thr Gly Ala Phe Gly Phe His Leu Trp Arg Arg Gln Trp Arg Pro 
465                 470                 475                 480 


Arg Arg Phe Ser Ala Leu Glu Gln Gly Ile His Pro Pro Gln Ala Gln 
                485                 490                 495     


Ser Lys Ile Glu Glu Leu Glu Gln Glu Pro Glu Pro Glu Pro Glu Pro 
            500                 505                 510         


Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Gln Leu 
        515                 520                 525 


<210>  64
<211>  343
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  64

Val Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val 
1               5                   10                  15      


Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg 
            20                  25                  30          


Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val 
        35                  40                  45              


Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe 
    50                  55                  60                  


Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala 
65                  70                  75                  80  


Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn 
                85                  90                  95      


Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala 
            100                 105                 110         


Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly 
        115                 120                 125             


Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln 
    130                 135                 140                 


Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn 
145                 150                 155                 160 


Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu 
                165                 170                 175     


Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg 
            180                 185                 190         


Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly 
        195                 200                 205             


Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp 
    210                 215                 220                 


Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys 
225                 230                 235                 240 


Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu 
                245                 250                 255     


Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile 
            260                 265                 270         


Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly 
        275                 280                 285             


His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val 
    290                 295                 300                 


Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile 
305                 310                 315                 320 


Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val 
                325                 330                 335     


Arg Leu Leu Glu Asp Gly Asp 
            340             


<210>  65
<211>  436
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Met Ser Gln Phe Asp Ile Leu Cys Lys Thr Pro Pro Lys Val Leu Val 
1               5                   10                  15      


Arg Gln Phe Val Glu Arg Phe Glu Arg Pro Ser Gly Glu Lys Ile Ala 
            20                  25                  30          


Ser Cys Ala Ala Glu Leu Thr Tyr Leu Cys Trp Met Ile Thr His Asn 
        35                  40                  45              


Gly Thr Ala Ile Lys Arg Ala Thr Phe Met Ser Tyr Asn Thr Ile Ile 
    50                  55                  60                  


Ser Asn Ser Leu Ser Phe Asp Ile Val Asn Lys Ser Leu Gln Phe Lys 
65                  70                  75                  80  


Tyr Lys Thr Gln Lys Ala Thr Ile Leu Glu Ala Ser Leu Lys Lys Leu 
                85                  90                  95      


Ile Pro Ala Trp Glu Phe Thr Ile Ile Pro Tyr Asn Gly Gln Lys His 
            100                 105                 110         


Gln Ser Asp Ile Thr Asp Ile Val Ser Ser Leu Gln Leu Gln Phe Glu 
        115                 120                 125             


Ser Ser Glu Glu Ala Asp Lys Gly Asn Ser His Ser Lys Lys Met Leu 
    130                 135                 140                 


Lys Ala Leu Leu Ser Glu Gly Glu Ser Ile Trp Glu Ile Thr Glu Lys 
145                 150                 155                 160 


Ile Leu Asn Ser Phe Glu Tyr Thr Ser Arg Phe Thr Lys Thr Lys Thr 
                165                 170                 175     


Leu Tyr Gln Phe Leu Phe Leu Ala Thr Phe Ile Asn Cys Gly Arg Phe 
            180                 185                 190         


Ser Asp Ile Lys Asn Val Asp Pro Lys Ser Phe Lys Leu Val Gln Asn 
        195                 200                 205             


Lys Tyr Leu Gly Val Ile Ile Gln Cys Leu Val Thr Glu Thr Lys Thr 
    210                 215                 220                 


Ser Val Ser Arg His Ile Tyr Phe Phe Ser Ala Arg Gly Arg Ile Asp 
225                 230                 235                 240 


Pro Leu Val Tyr Leu Asp Glu Phe Leu Arg Asn Ser Glu Pro Val Leu 
                245                 250                 255     


Lys Arg Val Asn Arg Thr Gly Asn Ser Ser Ser Asn Lys Gln Glu Tyr 
            260                 265                 270         


Gln Leu Leu Lys Asp Asn Leu Val Arg Ser Tyr Asn Lys Ala Leu Lys 
        275                 280                 285             


Lys Asn Ala Pro Tyr Pro Ile Phe Ala Ile Lys Asn Gly Pro Lys Ser 
    290                 295                 300                 


His Ile Gly Arg His Leu Met Thr Ser Phe Leu Ser Met Lys Gly Leu 
305                 310                 315                 320 


Thr Glu Leu Thr Asn Val Val Gly Asn Trp Ser Asp Lys Arg Ala Ser 
                325                 330                 335     


Ala Val Ala Arg Thr Thr Tyr Thr His Gln Ile Thr Ala Ile Pro Asp 
            340                 345                 350         


His Tyr Phe Ala Leu Val Ser Arg Tyr Tyr Ala Tyr Asp Pro Ile Ser 
        355                 360                 365             


Lys Glu Met Ile Ala Leu Lys Asp Glu Thr Asn Pro Ile Glu Glu Trp 
    370                 375                 380                 


Gln His Ile Glu Gln Leu Lys Gly Ser Ala Glu Gly Ser Ile Arg Tyr 
385                 390                 395                 400 


Pro Ala Trp Asn Gly Ile Ile Ser Gln Glu Val Leu Asp Tyr Leu Ser 
                405                 410                 415     


Ser Tyr Ile Asn Arg Arg Ile Gly Pro Val Glu Gln Lys Leu Ile Ser 
            420                 425                 430         


Glu Glu Asp Leu 
        435     


<210>  66
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  66

Gly Asn Arg Ser Ser His Ser Arg Leu Gly Arg Ile Glu Ala Asp Ser 
1               5                   10                  15      


Glu Ser Gln Glu Asp Ile Ile Arg Asn Ile Ala Arg His Leu Ala Gln 
            20                  25                  30          


Val Gly Asp Ser Met Asp Arg Ser Ile Pro Pro Gly Leu Val Asn Gly 
        35                  40                  45              


Leu Ala Glu Asp Arg Asn Arg Asp Leu Ala Thr Ala Leu Glu Gln Leu 
    50                  55                  60                  


Leu Gln Ala Tyr Pro Arg Asp Met Glu Lys Glu Lys Thr Met Leu Val 
65                  70                  75                  80  


Leu Ala Leu Leu Leu Ala Lys Lys Val Ala Ser His Thr Pro Ser Leu 
                85                  90                  95      


Leu Arg Asp Val Phe His Thr Thr Val Asn Phe Ile Asn Gln Asn Leu 
            100                 105                 110         


Arg Thr Tyr Val Arg Ser Leu Ala Arg Asn Gly Met Asp 
        115                 120                 125 


<210>  67
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Val Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
1               5                   10                  15      


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
            20                  25                  30          


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
        35                  40                  45              


Asp Met Leu Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Leu Glu 
    50                  55                  60                  


Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu Thr Arg 
65                  70                  75                  80  


Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg Val Ser 
                85                  90                  95      


Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
            100                 105                 


<210>  68
<211>  205
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  68

Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly 
        35                  40                  45              


Gly Ser Gly Gly Ser Gly Gly Ser Met Lys Leu Leu Ser Ser Ile Glu 
    50                  55                  60                  


Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu 
65                  70                  75                  80  


Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr 
                85                  90                  95      


Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu 
            100                 105                 110         


Val Glu Ser Arg Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe 
        115                 120                 125             


Pro Arg Glu Asp Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp 
    130                 135                 140                 


Ile Lys Ala Leu Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys 
145                 150                 155                 160 


Asp Ala Val Thr Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu 
                165                 170                 175     


Thr Leu Arg Gln His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser 
            180                 185                 190         


Ser Asn Lys Gly Gln Arg Gln Leu Thr Val Ser Ala Ala 
        195                 200                 205 


<210>  69
<211>  248
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  69

Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro 
        195                 200                 205             


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
    210                 215                 220                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp 
225                 230                 235                 240 


Phe Asp Leu Asp Met Leu Pro Gly 
                245             


<210>  70
<211>  211
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp 
145                 150                 155                 160 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
                165                 170                 175     


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
            180                 185                 190         


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        195                 200                 205             


Leu Gly Ser 
    210     


<210>  71
<211>  535
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  71

Met Gly Ile Val Glu Pro Gly Cys Gly Asp Met Leu Thr Gly Thr Glu 
1               5                   10                  15      


Pro Met Pro Gly Ser Asp Glu Gly Arg Ala Pro Gly Ala Asp Pro Gln 
            20                  25                  30          


His Arg Tyr Phe Tyr Pro Glu Pro Gly Ala Gln Asp Ala Asp Glu Arg 
        35                  40                  45              


Arg Gly Gly Gly Ser Leu Gly Ser Pro Tyr Pro Gly Gly Ala Leu Val 
    50                  55                  60                  


Pro Ala Pro Pro Ser Arg Phe Leu Gly Ala Tyr Ala Tyr Pro Pro Arg 
65                  70                  75                  80  


Pro Gln Ala Ala Gly Phe Pro Gly Ala Gly Glu Ser Phe Pro Pro Pro 
                85                  90                  95      


Ala Asp Ala Glu Gly Tyr Gln Pro Gly Glu Gly Tyr Ala Ala Pro Asp 
            100                 105                 110         


Pro Arg Ala Gly Leu Tyr Pro Gly Pro Arg Glu Asp Tyr Ala Leu Pro 
        115                 120                 125             


Ala Gly Leu Glu Val Ser Gly Lys Leu Arg Val Ala Leu Asn Asn His 
    130                 135                 140                 


Leu Leu Trp Ser Lys Phe Asn Gln His Gln Thr Glu Met Ile Ile Thr 
145                 150                 155                 160 


Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Thr Val Ala Gly 
                165                 170                 175     


Leu Glu Pro Thr Ser His Tyr Arg Met Phe Val Asp Val Val Leu Val 
            180                 185                 190         


Asp Gln His His Trp Arg Tyr Gln Ser Gly Lys Trp Val Gln Cys Gly 
        195                 200                 205             


Lys Ala Glu Gly Ser Met Pro Gly Asn Arg Leu Tyr Val His Pro Asp 
    210                 215                 220                 


Ser Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Val Ser Phe Gly 
225                 230                 235                 240 


Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn Val Thr Gln 
                245                 250                 255     


Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu His Ile 
            260                 265                 270         


Val Glu Val Asn Asp Gly Glu Pro Glu Ala Ala Cys Asn Ala Ser Asn 
        275                 280                 285             


Thr His Ile Phe Thr Phe Gln Glu Thr Gln Phe Ile Ala Val Thr Ala 
    290                 295                 300                 


Tyr Gln Asn Ala Glu Ile Thr Gln Leu Lys Ile Asp Asn Asn Pro Phe 
305                 310                 315                 320 


Ala Lys Gly Phe Arg Glu Asn Phe Glu Ser Met Tyr Thr Ser Val Asp 
                325                 330                 335     


Thr Ser Ile Pro Ser Pro Pro Gly Pro Asn Cys Gln Phe Leu Gly Gly 
            340                 345                 350         


Asp His Tyr Ser Pro Leu Leu Pro Asn Gln Tyr Pro Val Pro Ser Arg 
        355                 360                 365             


Phe Tyr Pro Asp Leu Pro Gly Gln Ala Lys Asp Val Val Pro Gln Ala 
    370                 375                 380                 


Tyr Trp Leu Gly Ala Pro Arg Asp His Ser Tyr Glu Ala Glu Phe Arg 
385                 390                 395                 400 


Ala Val Ser Met Lys Pro Ala Phe Leu Pro Ser Ala Pro Gly Pro Thr 
                405                 410                 415     


Met Ser Tyr Tyr Arg Gly Gln Glu Val Leu Ala Pro Gly Ala Gly Trp 
            420                 425                 430         


Pro Val Ala Pro Gln Tyr Pro Pro Lys Met Gly Pro Ala Ser Trp Phe 
        435                 440                 445             


Arg Pro Met Arg Thr Leu Pro Met Glu Pro Gly Pro Gly Gly Ser Glu 
    450                 455                 460                 


Gly Arg Gly Pro Glu Asp Gln Gly Pro Pro Leu Val Trp Thr Glu Ile 
465                 470                 475                 480 


Ala Pro Ile Arg Pro Glu Ser Ser Asp Ser Gly Leu Gly Glu Gly Asp 
                485                 490                 495     


Ser Lys Arg Arg Arg Val Ser Pro Tyr Pro Ser Ser Gly Asp Ser Ser 
            500                 505                 510         


Ser Pro Ala Gly Ala Pro Ser Pro Phe Asp Lys Glu Ala Glu Gly Gln 
        515                 520                 525             


Phe Tyr Asn Tyr Phe Pro Asn 
    530                 535 


<210>  72
<211>  318
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  72

Met Glu Leu Leu Ser Pro Pro Leu Arg Asp Ile Asp Leu Thr Gly Pro 
1               5                   10                  15      


Asp Gly Ser Leu Cys Ser Phe Glu Thr Ala Asp Asp Phe Tyr Asp Asp 
            20                  25                  30          


Pro Cys Phe Asp Ser Pro Asp Leu Arg Phe Phe Glu Asp Leu Asp Pro 
        35                  40                  45              


Arg Leu Val His Met Gly Ala Leu Leu Lys Pro Glu Glu His Ala His 
    50                  55                  60                  


Phe Pro Thr Ala Val His Pro Gly Pro Gly Ala Arg Glu Asp Glu His 
65                  70                  75                  80  


Val Arg Ala Pro Ser Gly His His Gln Ala Gly Arg Cys Leu Leu Trp 
                85                  90                  95      


Ala Cys Lys Ala Cys Lys Arg Lys Thr Thr Asn Ala Asp Arg Arg Lys 
            100                 105                 110         


Ala Ala Thr Met Arg Glu Arg Arg Arg Leu Ser Lys Val Asn Glu Ala 
        115                 120                 125             


Phe Glu Thr Leu Lys Arg Cys Thr Ser Ser Asn Pro Asn Gln Arg Leu 
    130                 135                 140                 


Pro Lys Val Glu Ile Leu Arg Asn Ala Ile Arg Tyr Ile Glu Gly Leu 
145                 150                 155                 160 


Gln Ala Leu Leu Arg Asp Gln Asp Ala Ala Pro Pro Gly Ala Ala Ala 
                165                 170                 175     


Phe Tyr Ala Pro Gly Pro Leu Pro Pro Gly Arg Gly Ser Glu His Tyr 
            180                 185                 190         


Ser Gly Asp Ser Asp Ala Ser Ser Pro Arg Ser Asn Cys Ser Asp Gly 
        195                 200                 205             


Met Met Asp Tyr Ser Gly Pro Pro Ser Gly Pro Arg Arg Gln Asn Gly 
    210                 215                 220                 


Tyr Asp Thr Ala Tyr Tyr Ser Glu Ala Ala Arg Glu Ser Arg Pro Gly 
225                 230                 235                 240 


Lys Ser Ala Ala Val Ser Ser Leu Asp Cys Leu Ser Ser Ile Val Glu 
                245                 250                 255     


Arg Ile Ser Thr Asp Ser Pro Ala Ala Pro Ala Leu Leu Leu Ala Asp 
            260                 265                 270         


Ala Pro Pro Glu Ser Pro Pro Gly Pro Pro Glu Gly Ala Ser Leu Ser 
        275                 280                 285             


Asp Thr Glu Gln Gly Thr Gln Thr Pro Ser Pro Asp Ala Ala Pro Gln 
    290                 295                 300                 


Cys Pro Ala Gly Ser Asn Pro Asn Ala Ile Tyr Gln Val Leu 
305                 310                 315             


<210>  73
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  74
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  75
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  75

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  76
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  76

His His His His His 
1               5   


<210>  77
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  77

His His His His His His 
1               5       


<210>  78
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  78

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  79
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  79

Arg Tyr Ile Arg Ser 
1               5   


<210>  80
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  80

Phe His His Thr 
1               


<210>  81
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  81

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  82
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  82

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  83
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  83

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  84
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  84

Met Val Pro Lys Lys Lys Arg Lys 
1               5               


<210>  85
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  85

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala 
    


<210>  86
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  86

Arg Gln Arg Arg 
1               


<210>  87
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  87

Val Leu Leu Ser 
1               


<210>  88
<211>  206
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  88

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly 
        195                 200                 205     


<210>  89
<211>  273
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  89

Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala 
1               5                   10                  15      


Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu 
            20                  25                  30          


Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu 
        35                  40                  45              


Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu 
    50                  55                  60                  


Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln 
65                  70                  75                  80  


Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn 
                85                  90                  95      


Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly 
            100                 105                 110         


Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser 
        115                 120                 125             


Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp 
    130                 135                 140                 


Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp 
145                 150                 155                 160 


Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser 
                165                 170                 175     


Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly 
            180                 185                 190         


Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu 
        195                 200                 205             


Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met 
    210                 215                 220                 


Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys 
225                 230                 235                 240 


Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile 
                245                 250                 255     


Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp 
            260                 265                 270         


Lys 
    


<210>  90
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  90

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  91
<211>  244
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  91

Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            20                  25                  30          


Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ser Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly 
                165                 170                 175     


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Lys His Pro Leu Thr Tyr Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Ala Ser 
                


<210>  92
<211>  261
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  92

Gly Ser Gln Val Gln Leu Gln Gln Gln Val Gln Leu Gln Glu Ser Gly 
1               5                   10                  15      


Gly Asp Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala 
            20                  25                  30          


Ser Gly Phe Thr Phe Ser His Tyr Gly Met Ser Trp Val Arg Gln Thr 
        35                  40                  45              


Pro Asp Lys Arg Leu Glu Trp Val Ala Thr Ile Gly Ser Arg Gly Thr 
    50                  55                  60                  


Tyr Thr His Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
65                  70                  75                  80  


Asp Asn Asp Lys Asn Ala Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser 
                85                  90                  95      


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Ser Glu Phe Tyr Tyr 
            100                 105                 110         


Tyr Gly Asn Thr Tyr Tyr Tyr Ser Ala Met Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Ala Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Phe 
145                 150                 155                 160 


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
                165                 170                 175     


Glu Ser Val Asp Asn Tyr Gly Phe Ser Phe Met Asn Trp Phe Gln Gln 
            180                 185                 190         


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ile Ser Asn Arg 
        195                 200                 205             


Gly Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Pro Ala Met Tyr 
225                 230                 235                 240 


Phe Cys Gln Gln Thr Lys Glu Val Pro Trp Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys 
            260     


<210>  93
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  93

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Thr Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Arg Ile Thr Trp Ser Ala Gly Tyr Thr Ala Tyr Ser Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ser Arg Ser Ala Gly Tyr Ser Ser Ser Leu Thr Arg Arg 
            100                 105                 110         


Glu Asp Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125         


<210>  94
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  94

Met Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser 
            20                  25                  30          


Met Ala Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile Ser Arg Ser Ala Gly Ser Ala Val His Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Val Arg Thr Ser Gly Phe Phe Gly Ser Ile Pro Arg Thr 
            100                 105                 110         


Gly Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  95
<211>  128
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  95

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr 
1               5                   10                  15      


Gly Gly Ser Leu Lys Leu Ser Cys Thr Ala Ser Val Arg Thr Leu Ser 
            20                  25                  30          


Tyr Tyr His Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Gly Ile His Arg Ser Gly Glu Ser Thr Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val His Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gln Arg Val Arg Gly Phe Phe Gly Pro Leu Arg Ser Thr 
            100                 105                 110         


Pro Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


<210>  96
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  96

Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Ala 
1               5                   10                  15      


Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30          


Thr Ser Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Thr Trp Thr Val Gly Asn Thr Ile Leu Gly Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Ala Lys Asn Thr 
65                  70                  75                  80  


Val Asp Leu Gln Met Asp Asn Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Ala Arg Ser Arg Gly Tyr Val Leu Ser Val Leu Arg Ser 
            100                 105                 110         


Val Asp Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met 
    130                 135                 140                 


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn 
                165                 170                 175     


Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
            180                 185                 190         


Val Ala Ala Ile Ser Trp Thr Gly Val Ser Thr Tyr Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Val 
    210                 215                 220                 


Tyr Val Gln Met Asn Ser Leu Ile Pro Glu Asp Thr Ala Ile Tyr Tyr 
225                 230                 235                 240 


Cys Ala Ala Val Arg Ala Arg Ser Phe Ser Asp Thr Tyr Ser Arg Val 
                245                 250                 255     


Asn Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            260                 265                 270 


<210>  97
<211>  176
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  97

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu 
    50                  55                  60                  


Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala 
65                  70                  75                  80  


Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val 
                85                  90                  95      


Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala 
            100                 105                 110         


Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala 
        115                 120                 125             


Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr 
    130                 135                 140                 


Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg 
145                 150                 155                 160 


Pro Ala Gly Gln Phe Gln Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
                165                 170                 175     


<210>  98
<211>  185
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  98

Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr 
            20                  25                  30          


Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
        35                  40                  45              


Trp Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln 
    50                  55                  60                  


Lys Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
65                  70                  75                  80  


Ala Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
                85                  90                  95      


Phe Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ser Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly 
                165                 170                 175     


Thr Ser Pro Lys Arg Trp Ile Tyr Asp 
            180                 185 


<210>  99
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  99

Pro Lys Lys Lys Arg Lys Val Asp Ala Leu Asp Asp Phe Asp Leu Asp 
1               5                   10                  15      


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
            20                  25                  30          


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
        35                  40                  45              


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Gly Gly Ser Gly Gly 
    50                  55                  60                  


Ser Gly Gly Ser Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn 
65                  70                  75                  80  


Thr Ala Leu Glu Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg 
                85                  90                  95      


Leu Arg Asn Arg Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly 
            100                 105                 110         


Gly Gly Lys 
        115 


<210>  100
<211>  351
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  100

Met Val Pro Lys Lys Lys Arg Lys Val Ser Asn Leu Leu Thr Val His 
1               5                   10                  15      


Gln Asn Leu Pro Ala Leu Pro Val Asp Ala Thr Ser Asp Glu Val Arg 
            20                  25                  30          


Lys Asn Leu Met Asp Met Phe Arg Asp Arg Gln Ala Phe Ser Glu His 
        35                  40                  45              


Thr Trp Lys Met Leu Leu Ser Val Cys Arg Ser Trp Ala Ala Trp Cys 
    50                  55                  60                  


Lys Leu Asn Asn Arg Lys Trp Phe Pro Ala Glu Pro Glu Asp Val Arg 
65                  70                  75                  80  


Asp Tyr Leu Leu Tyr Leu Gln Ala Arg Gly Leu Ala Val Lys Thr Ile 
                85                  90                  95      


Gln Gln His Leu Gly Gln Leu Asn Met Leu His Arg Arg Ser Gly Leu 
            100                 105                 110         


Pro Arg Pro Ser Asp Ser Asn Ala Val Ser Leu Val Met Arg Arg Ile 
        115                 120                 125             


Arg Lys Glu Asn Val Asp Ala Gly Glu Arg Ala Lys Gln Ala Leu Ala 
    130                 135                 140                 


Phe Glu Arg Thr Asp Phe Asp Gln Val Arg Ser Leu Met Glu Asn Ser 
145                 150                 155                 160 


Asp Arg Cys Gln Asp Ile Arg Asn Leu Ala Phe Leu Gly Ile Ala Tyr 
                165                 170                 175     


Asn Thr Leu Leu Arg Ile Ala Glu Ile Ala Arg Ile Arg Val Lys Asp 
            180                 185                 190         


Ile Ser Arg Thr Asp Gly Gly Arg Met Leu Ile His Ile Gly Arg Thr 
        195                 200                 205             


Lys Thr Leu Val Ser Thr Ala Gly Val Glu Lys Ala Leu Ser Leu Gly 
    210                 215                 220                 


Val Thr Lys Leu Val Glu Arg Trp Ile Ser Val Ser Gly Val Ala Asp 
225                 230                 235                 240 


Asp Pro Asn Asn Tyr Leu Phe Cys Arg Val Arg Lys Asn Gly Val Ala 
                245                 250                 255     


Ala Pro Ser Ala Thr Ser Gln Leu Ser Thr Arg Ala Leu Glu Gly Ile 
            260                 265                 270         


Phe Glu Ala Thr His Arg Leu Ile Tyr Gly Ala Lys Asp Asp Ser Gly 
        275                 280                 285             


Gln Arg Tyr Leu Ala Trp Ser Gly His Ser Ala Arg Val Gly Ala Ala 
    290                 295                 300                 


Arg Asp Met Ala Arg Ala Gly Val Ser Ile Pro Glu Ile Met Gln Ala 
305                 310                 315                 320 


Gly Gly Trp Thr Asn Val Asn Ile Val Met Asn Tyr Ile Arg Asn Leu 
                325                 330                 335     


Asp Ser Glu Thr Gly Ala Met Val Arg Leu Leu Glu Asp Gly Asp 
            340                 345                 350     


<210>  101
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Leu or Gln.

<400>  101

Pro Xaa Gly Met Thr Ser 
1               5       


<210>  102
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be Leu or Gln.

<400>  102

Pro Xaa Gly Met Thr 
1               5   


<210>  103
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  103

Glu Asn Leu Tyr Thr Gln Ser 
1               5           


<210>  104
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  104

Asp Asp Asp Asp Lys 
1               5   


<210>  105
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  105

Leu Val Pro Arg 
1               


<210>  106
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  106

Leu Glu Val Leu Phe Gln Gly Pro 
1               5               


<210>  107
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  107

Cys Gly Leu Val Pro Ala Gly Ser Gly Pro 
1               5                   10  


<210>  108
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  108

Ser Leu Leu Lys Ser Arg Met Val Pro Asn Phe Asn 
1               5                   10          


<210>  109
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  109

Ser Leu Leu Ile Ala Arg Arg Met Pro Asn Phe Asn 
1               5                   10          


<210>  110
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  110

Ser Lys Leu Val Gln Ala Ser Ala Ser Gly Val Asn 
1               5                   10          


<210>  111
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  111

Ser Ser Tyr Leu Lys Ala Ser Asp Ala Pro Asp Asn 
1               5                   10          


<210>  112
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  112

Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met Asn 
1               5                   10          


<210>  113
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  113

Ser Leu Arg Pro Leu Ala Leu Trp Arg Ser Phe Asn 
1               5                   10          


<210>  114
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  114

Ser Pro Gln Gly Ile Ala Gly Gln Arg Asn Phe Asn 
1               5                   10          


<210>  115
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  115

Asp Val Asp Glu Arg Asp Val Arg Gly Phe Ala Ser Phe Leu 
1               5                   10                  


<210>  116
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  116

Ser Leu Pro Leu Gly Leu Trp Ala Pro Asn Phe Asn 
1               5                   10          


<210>  117
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  117

Ser Leu Leu Ile Phe Arg Ser Trp Ala Asn Phe Asn 
1               5                   10          


<210>  118
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  118

Ser Gly Val Val Ile Ala Thr Val Ile Val Ile Thr 
1               5                   10          


<210>  119
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  119

Ser Leu Gly Pro Gln Gly Ile Trp Gly Gln Phe Asn 
1               5                   10          


<210>  120
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  120

Lys Lys Ser Pro Gly Arg Val Val Gly Gly Ser Val 
1               5                   10          


<210>  121
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  121

Pro Gln Gly Leu Leu Gly Ala Pro Gly Ile Leu Gly 
1               5                   10          


<210>  122
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  122

His Gly Pro Glu Gly Leu Arg Val Gly Phe Tyr Glu Ser Asp Val Met 
1               5                   10                  15      


Gly Arg Gly His Ala Arg Leu Val His Val Glu Glu Pro His Thr 
            20                  25                  30      


<210>  123
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  123

Gly Pro Gln Gly Leu Ala Gly Gln Arg Gly Ile Val 
1               5                   10          


<210>  124
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  124

Gly Gly Ser Gly Gln Arg Gly Arg Lys Ala Leu Glu 
1               5                   10          


<210>  125
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  125

Ser Leu Ser Ala Leu Leu Ser Ser Asp Ile Phe Asn 
1               5                   10          


<210>  126
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  126

Ser Leu Pro Arg Phe Lys Ile Ile Gly Gly Phe Asn 
1               5                   10          


<210>  127
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  127

Ser Leu Leu Gly Ile Ala Val Pro Gly Asn Phe Asn 
1               5                   10          


<210>  128
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  128

Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro 
1               5                   10          


<210>  129
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  129

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  130
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  130
ggagcactgt cctccgaacg                                                   20


<210>  131
<211>  2555
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Pro Pro Leu Leu Ala Pro Leu Leu Cys Leu Ala Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Pro Arg Cys Ser Gln Pro Gly Glu Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Lys Cys Glu Ala Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Gly Gly Ala Phe Val Gly Pro Arg Cys Gln Asp Pro Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp Arg Arg 
65                  70                  75                  80  


Gly Val Ala Asp Tyr Ala Cys Ser Cys Ala Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Thr Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ala 
145                 150                 155                 160 


Ser Tyr Ile Cys His Cys Pro Pro Ser Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Gly Gln Lys Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Val Gly Ser Tyr Arg Cys Val Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro Asn Cys Glu Arg Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Val Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Ile Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe His Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Ile Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val His Cys Glu Val Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Leu Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Arg 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys Ser 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala 
    610                 615                 620                 


Tyr Leu Cys Phe Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Ser Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Ile Asn Ile Asp Glu Cys Ala Gly Asn Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Asn Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Val His Gly Ala Cys Arg Asp Ser Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Asp Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Leu Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Pro Ser Pro Cys Arg Asn Gly Gly Glu Cys Arg Gln Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Leu Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr His Gly Gly Tyr Arg Cys His Cys Gln 
                885                 890                 895     


Ala Gly Tyr Ser Gly Arg Asn Cys Glu Thr Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Arg Gly Thr Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asp Pro Cys Arg Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Ala Gly Phe Ser 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln His  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Gln Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Gly Cys  Gly Ser Tyr Arg Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Pro Asn  Cys Gln Asn Leu Val  His Trp Cys Asp Ser  Ser Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr His Thr Gln  Tyr Arg Cys 
    1070                 1075                 1080             


Glu Cys  Pro Ser Gly Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Arg Gln Gly Val  Asp Val Ala 
    1100                 1105                 1110             


Arg Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Ala  Gly Asn Thr 
    1115                 1120                 1125             


His His  Cys Arg Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Leu  Val Asp Glu Cys Ser  Pro Ser Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Tyr Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Val Asn Cys  Ser Glu Glu Ile Asp  Glu Cys Leu 
    1175                 1180                 1185             


Ser His  Pro Cys Gln Asn Gly  Gly Thr Cys Leu Asp  Leu Pro Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  Asn Pro Pro Val Asp  Pro Val Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Ser Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Lys Gly Lys Pro  Cys Lys Asn Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Lys  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Pro Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Leu Gly Gly Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Gly Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Leu Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Ser Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Arg Ala Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Val Val Val 
    1565                 1570                 1575             


Leu Met  Pro Pro Glu Gln Leu  Arg Asn Ser Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser Arg Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  His Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ala Ala  Glu Gly Trp 
    1625                 1630                 1635             


Ala Ala  Pro Asp Ala Leu Leu  Gly Gln Val Lys Ala  Ser Leu Leu 
    1640                 1645                 1650             


Pro Gly  Gly Ser Glu Gly Gly  Arg Arg Arg Arg Glu  Leu Asp Pro 
    1655                 1660                 1665             


Met Asp  Val Arg Gly Ser Ile  Val Tyr Leu Glu Ile  Asp Asn Arg 
    1670                 1675                 1680             


Gln Cys  Val Gln Ala Ser Ser  Gln Cys Phe Gln Ser  Ala Thr Asp 
    1685                 1690                 1695             


Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser Leu Gly  Ser Leu Asn 
    1700                 1705                 1710             


Ile Pro  Tyr Lys Ile Glu Ala  Val Gln Ser Glu Thr  Val Glu Pro 
    1715                 1720                 1725             


Pro Pro  Pro Ala Gln Leu His  Phe Met Tyr Val Ala  Ala Ala Ala 
    1730                 1735                 1740             


Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly Val Leu  Leu Ser Arg 
    1745                 1750                 1755             


Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp Phe Pro  Glu Gly Phe 
    1760                 1765                 1770             


Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg Arg Glu  Pro Leu Gly 
    1775                 1780                 1785             


Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys Asn Ala  Ser Asp Gly 
    1790                 1795                 1800             


Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp Gly Asp  Glu Asp Leu 
    1805                 1810                 1815             


Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro Val Val  Leu Pro Asp 
    1820                 1825                 1830             


Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp Thr Gln  Gln His Leu 
    1835                 1840                 1845             


Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met Ala Pro  Thr Pro Pro 
    1850                 1855                 1860             


Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp Val Asn  Val Arg Gly 
    1865                 1870                 1875             


Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly 
    1880                 1885                 1890             


Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu Glu Asp  Ala Pro Ala 
    1895                 1900                 1905             


Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln 
    1910                 1915                 1920             


Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr 
    1925                 1930                 1935             


Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp 
    1940                 1945                 1950             


Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr Pro Leu  His Ala Ala 
    1955                 1960                 1965             


Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn 
    1970                 1975                 1980             


Arg Ala  Thr Asp Leu Asp Ala  Arg Met His Asp Gly  Thr Thr Pro 
    1985                 1990                 1995             


Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp 
    2000                 2005                 2010             


Leu Ile  Asn Ser His Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly 
    2015                 2020                 2025             


Lys Ser  Ala Leu His Trp Ala  Ala Ala Val Asn Asn  Val Asp Ala 
    2030                 2035                 2040             


Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn 
    2045                 2050                 2055             


Asn Arg  Glu Glu Thr Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser 
    2060                 2065                 2070             


Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His Phe Ala  Asn Arg Asp 
    2075                 2080                 2085             


Ile Thr  Asp His Met Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu 
    2090                 2095                 2100             


Arg Met  His His Asp Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu 
    2105                 2110                 2115             


Val Arg  Ser Pro Gln Leu His  Gly Ala Pro Leu Gly  Gly Thr Pro 
    2120                 2125                 2130             


Thr Leu  Ser Pro Pro Leu Cys  Ser Pro Asn Gly Tyr  Leu Gly Ser 
    2135                 2140                 2145             


Leu Lys  Pro Gly Val Gln Gly  Lys Lys Val Arg Lys  Pro Ser Ser 
    2150                 2155                 2160             


Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala Lys Asp  Leu Lys Ala 
    2165                 2170                 2175             


Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly Cys Leu  Leu Asp Ser 
    2180                 2185                 2190             


Ser Gly  Met Leu Ser Pro Val  Asp Ser Leu Glu Ser  Pro His Gly 
    2195                 2200                 2205             


Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu Leu Pro  Ser Pro Phe 
    2210                 2215                 2220             


Gln Gln  Ser Pro Ser Val Pro  Leu Asn His Leu Pro  Gly Met Pro 
    2225                 2230                 2235             


Asp Thr  His Leu Gly Ile Gly  His Leu Asn Val Ala  Ala Lys Pro 
    2240                 2245                 2250             


Glu Met  Ala Ala Leu Gly Gly  Gly Gly Arg Leu Ala  Phe Glu Thr 
    2255                 2260                 2265             


Gly Pro  Pro Arg Leu Ser His  Leu Pro Val Ala Ser  Gly Thr Ser 
    2270                 2275                 2280             


Thr Val  Leu Gly Ser Ser Ser  Gly Gly Ala Leu Asn  Phe Thr Val 
    2285                 2290                 2295             


Gly Gly  Ser Thr Ser Leu Asn  Gly Gln Cys Glu Trp  Leu Ser Arg 
    2300                 2305                 2310             


Leu Gln  Ser Gly Met Val Pro  Asn Gln Tyr Asn Pro  Leu Arg Gly 
    2315                 2320                 2325             


Ser Val  Ala Pro Gly Pro Leu  Ser Thr Gln Ala Pro  Ser Leu Gln 
    2330                 2335                 2340             


His Gly  Met Val Gly Pro Leu  His Ser Ser Leu Ala  Ala Ser Ala 
    2345                 2350                 2355             


Leu Ser  Gln Met Met Ser Tyr  Gln Gly Leu Pro Ser  Thr Arg Leu 
    2360                 2365                 2370             


Ala Thr  Gln Pro His Leu Val  Gln Thr Gln Gln Val  Gln Pro Gln 
    2375                 2380                 2385             


Asn Leu  Gln Met Gln Gln Gln  Asn Leu Gln Pro Ala  Asn Ile Gln 
    2390                 2395                 2400             


Gln Gln  Gln Ser Leu Gln Pro  Pro Pro Pro Pro Pro  Gln Pro His 
    2405                 2410                 2415             


Leu Gly  Val Ser Ser Ala Ala  Ser Gly His Leu Gly  Arg Ser Phe 
    2420                 2425                 2430             


Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val Gln Pro  Leu Gly Pro 
    2435                 2440                 2445             


Ser Ser  Leu Ala Val His Thr  Ile Leu Pro Gln Glu  Ser Pro Ala 
    2450                 2455                 2460             


Leu Pro  Thr Ser Leu Pro Ser  Ser Leu Val Pro Pro  Val Thr Ala 
    2465                 2470                 2475             


Ala Gln  Phe Leu Thr Pro Pro  Ser Gln His Ser Tyr  Ser Ser Pro 
    2480                 2485                 2490             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2495                 2500                 2505             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2510                 2515                 2520             


Ser Pro  His Ser Asn Val Ser  Asp Trp Ser Glu Gly  Val Ser Ser 
    2525                 2530                 2535             


Pro Pro  Thr Ser Met Gln Ser  Gln Ile Ala Arg Ile  Pro Glu Ala 
    2540                 2545                 2550             


Phe Lys  
    2555 


<210>  132
<211>  2531
<212>  PRT
<213>  Mus musculus

<400>  132

Met Pro Arg Leu Leu Thr Pro Leu Leu Cys Leu Thr Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Leu Arg Cys Ser Gln Pro Ser Gly Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Arg Cys Glu Val Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Ser Gly Ala Phe Val Gly Gln Arg Cys Gln Asp Ser Asn Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys His Val Val Asp His Gly 
65                  70                  75                  80  


Gly Thr Val Asp Tyr Ala Cys Ser Cys Pro Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Asp Asn Ala Cys Leu Ala Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ser 
145                 150                 155                 160 


Ser Tyr Ile Cys Arg Cys Pro Pro Gly Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Ser Gln Asn Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Ile Gly Ser Tyr Arg Cys Ala Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Thr Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Ala Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Val Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe Gln Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ala Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Leu Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Ile Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val Tyr Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly His Cys Met Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Gln Cys Gln Cys Pro Lys Gly Phe Asn Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Gln 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys His 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Ser 
    610                 615                 620                 


Tyr Leu Cys Leu Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Asn Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Val Asn Ile Asp Glu Cys Ala Gly Ser Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Ala Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Ile His Gly Ala Cys Arg Asp Gly Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Ala Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Pro Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Thr Ser Pro Cys Lys Asn Ser Gly Val Cys Lys Glu Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Val Asp Ile Asn Glu Cys Val Lys Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Gln 
                885                 890                 895     


Ala Gly Tyr Thr Gly Arg Asn Cys Glu Ser Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Ile Asn Thr 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Gln Gly Ala Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Ser Asn Pro Cys Gln Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Val Gly Phe Asn 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln Tyr  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Arg Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Ser Tyr  Gly Thr Tyr Lys Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Leu Asn  Cys Gln Asn Leu Val  Arg Trp Cys Asp Ser  Ala Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Arg Cys Trp  Gln Thr Asn Thr Gln  Tyr His Cys 
    1070                 1075                 1080             


Glu Cys  Arg Ser Gly Trp Thr  Gly Val Asn Cys Asp  Val Leu Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Lys Arg Gly Ile  Asp Val Thr 
    1100                 1105                 1110             


Leu Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Glu  Gly Asp Lys 
    1115                 1120                 1125             


His Tyr  Cys His Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Glu  Val Asp Glu Cys Ser  Pro Asn Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Phe Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Ser Asn Cys  Ser Glu Glu Ile Asn  Glu Cys Leu 
    1175                 1180                 1185             


Ser Gln  Pro Cys Gln Asn Gly  Gly Thr Cys Ile Asp  Leu Thr Asn 
    1190                 1195                 1200             


Ser Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  His Pro Pro Leu Asp  Pro Ala Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Thr Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Pro 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Arg Gly Lys Pro  Cys Lys Asn Gly Gly  Val Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Arg  Cys Pro Ala 
    1325                 1330                 1335             


Gly Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Ser Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Val Gly Ser Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Asn Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Thr Gly Gly  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Gln Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Val Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Asn Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Leu Thr Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Leu Val Val 
    1565                 1570                 1575             


Leu Leu  Pro Pro Asp Gln Leu  Arg Asn Asn Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Glu  Leu Ser His Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  Gln Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly His Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ser Thr  Val Gly Trp 
    1625                 1630                 1635             


Ala Thr  Ser Ser Leu Leu Pro  Gly Thr Ser Gly Gly  Arg Gln Arg 
    1640                 1645                 1650             


Arg Glu  Leu Asp Pro Met Asp  Ile Arg Gly Ser Ile  Val Tyr Leu 
    1655                 1660                 1665             


Glu Ile  Asp Asn Arg Gln Cys  Val Gln Ser Ser Ser  Gln Cys Phe 
    1670                 1675                 1680             


Gln Ser  Ala Thr Asp Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser 
    1685                 1690                 1695             


Leu Gly  Ser Leu Asn Ile Pro  Tyr Lys Ile Glu Ala  Val Lys Ser 
    1700                 1705                 1710             


Glu Pro  Val Glu Pro Pro Leu  Pro Ser Gln Leu His  Leu Met Tyr 
    1715                 1720                 1725             


Val Ala  Ala Ala Ala Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly 
    1730                 1735                 1740             


Val Leu  Leu Ser Arg Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp 
    1745                 1750                 1755             


Phe Pro  Glu Gly Phe Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg 
    1760                 1765                 1770             


Arg Glu  Pro Leu Gly Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys 
    1775                 1780                 1785             


Asn Ala  Ser Asp Gly Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp 
    1790                 1795                 1800             


Gly Asp  Glu Asp Leu Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro 
    1805                 1810                 1815             


Val Val  Leu Pro Asp Leu Ser  Asp Gln Thr Asp His  Arg Gln Trp 
    1820                 1825                 1830             


Thr Gln  Gln His Leu Asp Ala  Ala Asp Leu Arg Met  Ser Ala Met 
    1835                 1840                 1845             


Ala Pro  Thr Pro Pro Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp 
    1850                 1855                 1860             


Val Asn  Val Arg Gly Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala 
    1865                 1870                 1875             


Ser Cys  Ser Gly Gly Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu 
    1880                 1885                 1890             


Glu Asp  Ala Pro Ala Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala 
    1895                 1900                 1905             


Ser Leu  His Asn Gln Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His 
    1910                 1915                 1920             


Leu Ala  Ala Arg Tyr Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu 
    1925                 1930                 1935             


Glu Ala  Ser Ala Asp Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr 
    1940                 1945                 1950             


Pro Leu  His Ala Ala Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln 
    1955                 1960                 1965             


Ile Leu  Leu Arg Asn Arg Ala  Thr Asp Leu Asp Ala  Arg Met His 
    1970                 1975                 1980             


Asp Gly  Thr Thr Pro Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu 
    1985                 1990                 1995             


Gly Met  Leu Glu Asp Leu Ile  Asn Ser His Ala Asp  Val Asn Ala 
    2000                 2005                 2010             


Val Asp  Asp Leu Gly Lys Ser  Ala Leu His Trp Ala  Ala Ala Val 
    2015                 2020                 2025             


Asn Asn  Val Asp Ala Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn 
    2030                 2035                 2040             


Lys Asp  Met Gln Asn Asn Lys  Glu Glu Thr Pro Leu  Phe Leu Ala 
    2045                 2050                 2055             


Ala Arg  Glu Gly Ser Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His 
    2060                 2065                 2070             


Phe Ala  Asn Arg Asp Ile Thr  Asp His Met Asp Arg  Leu Pro Arg 
    2075                 2080                 2085             


Asp Ile  Ala Gln Glu Arg Met  His His Asp Ile Val  Arg Leu Leu 
    2090                 2095                 2100             


Asp Glu  Tyr Asn Leu Val Arg  Ser Pro Gln Leu His  Gly Thr Ala 
    2105                 2110                 2115             


Leu Gly  Gly Thr Pro Thr Leu  Ser Pro Thr Leu Cys  Ser Pro Asn 
    2120                 2125                 2130             


Gly Tyr  Leu Gly Asn Leu Lys  Ser Ala Thr Gln Gly  Lys Lys Ala 
    2135                 2140                 2145             


Arg Lys  Pro Ser Thr Lys Gly  Leu Ala Cys Gly Ser  Lys Glu Ala 
    2150                 2155                 2160             


Lys Asp  Leu Lys Ala Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly 
    2165                 2170                 2175             


Cys Leu  Leu Asp Ser Ser Ser  Met Leu Ser Pro Val  Asp Ser Leu 
    2180                 2185                 2190             


Glu Ser  Pro His Gly Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu 
    2195                 2200                 2205             


Leu Pro  Ser Pro Phe Gln Gln  Ser Pro Ser Met Pro  Leu Ser His 
    2210                 2215                 2220             


Leu Pro  Gly Met Pro Asp Thr  His Leu Gly Ile Ser  His Leu Asn 
    2225                 2230                 2235             


Val Ala  Ala Lys Pro Glu Met  Ala Ala Leu Ala Gly  Gly Ser Arg 
    2240                 2245                 2250             


Leu Ala  Phe Glu Pro Pro Pro  Pro Arg Leu Ser His  Leu Pro Val 
    2255                 2260                 2265             


Ala Ser  Ser Ala Ser Thr Val  Leu Ser Thr Asn Gly  Thr Gly Ala 
    2270                 2275                 2280             


Met Asn  Phe Thr Val Gly Ala  Pro Ala Ser Leu Asn  Gly Gln Cys 
    2285                 2290                 2295             


Glu Trp  Leu Pro Arg Leu Gln  Asn Gly Met Val Pro  Ser Gln Tyr 
    2300                 2305                 2310             


Asn Pro  Leu Arg Pro Gly Val  Thr Pro Gly Thr Leu  Ser Thr Gln 
    2315                 2320                 2325             


Ala Ala  Gly Leu Gln His Ser  Met Met Gly Pro Leu  His Ser Ser 
    2330                 2335                 2340             


Leu Ser  Thr Asn Thr Leu Ser  Pro Ile Ile Tyr Gln  Gly Leu Pro 
    2345                 2350                 2355             


Asn Thr  Arg Leu Ala Thr Gln  Pro His Leu Val Gln  Thr Gln Gln 
    2360                 2365                 2370             


Val Gln  Pro Gln Asn Leu Gln  Leu Gln Pro Gln Asn  Leu Gln Pro 
    2375                 2380                 2385             


Pro Ser  Gln Pro His Leu Ser  Val Ser Ser Ala Ala  Asn Gly His 
    2390                 2395                 2400             


Leu Gly  Arg Ser Phe Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val 
    2405                 2410                 2415             


Gln Pro  Leu Gly Pro Ser Ser  Leu Pro Val His Thr  Ile Leu Pro 
    2420                 2425                 2430             


Gln Glu  Ser Gln Ala Leu Pro  Thr Ser Leu Pro Ser  Ser Met Val 
    2435                 2440                 2445             


Pro Pro  Met Thr Thr Thr Gln  Phe Leu Thr Pro Pro  Ser Gln His 
    2450                 2455                 2460             


Ser Tyr  Ser Ser Ser Pro Val  Asp Asn Thr Pro Ser  His Gln Leu 
    2465                 2470                 2475             


Gln Val  Pro Glu His Pro Phe  Leu Thr Pro Ser Pro  Glu Ser Pro 
    2480                 2485                 2490             


Asp Gln  Trp Ser Ser Ser Ser  Pro His Ser Asn Ile  Ser Asp Trp 
    2495                 2500                 2505             


Ser Glu  Gly Ile Ser Ser Pro  Pro Thr Thr Met Pro  Ser Gln Ile 
    2510                 2515                 2520             


Thr His  Ile Pro Glu Ala Phe  Lys 
    2525                 2530     


<210>  133
<211>  1429
<212>  PRT
<213>  Caenorhabditis elegans

<400>  133

Met Arg Ile Pro Thr Ile Cys Phe Leu Phe Leu Leu Ile Ser Leu Ser 
1               5                   10                  15      


Lys Ser Leu His Ile Gly Ser Cys Leu Gly Leu Ile Cys Gly Arg Asn 
            20                  25                  30          


Gly His Cys His Ala Gly Pro Val Asn Gly Thr Gln Thr Ser Tyr Trp 
        35                  40                  45              


Cys Arg Cys Asp Glu Gly Phe Gly Gly Glu Tyr Cys Glu Gln Gln Cys 
    50                  55                  60                  


Asp Val Ser Lys Cys Gly Ala Asp Glu Lys Cys Val Phe Asp Lys Asp 
65                  70                  75                  80  


Tyr Arg Met Glu Thr Cys Val Cys Lys Asp Cys Asp Ile Asn Gly Asn 
                85                  90                  95      


Ser Leu Leu Lys Pro Ser Cys Pro Ser Gly Tyr Gly Gly Asp Asp Cys 
            100                 105                 110         


Lys Thr Gln Gly Trp Cys Tyr Pro Ser Val Cys Met Asn Gly Gly Gln 
        115                 120                 125             


Cys Ile Gly Ala Gly Asn Arg Ala Lys Cys Ala Cys Pro Asp Gly Phe 
    130                 135                 140                 


Lys Gly Glu Arg Cys Glu Leu Asp Val Asn Glu Cys Glu Glu Asn Lys 
145                 150                 155                 160 


Asn Ala Cys Gly Asn Arg Ser Thr Cys Met Asn Thr Leu Gly Thr Tyr 
                165                 170                 175     


Ile Cys Val Cys Pro Gln Gly Phe Leu Pro Pro Asp Cys Leu Lys Pro 
            180                 185                 190         


Gly Asn Thr Ser Thr Val Glu Phe Lys Gln Pro Val Cys Phe Leu Glu 
        195                 200                 205             


Ile Ser Ala Asp His Pro Asp Gly Arg Ser Met Tyr Cys Gln Asn Gly 
    210                 215                 220                 


Gly Phe Cys Asp Lys Ala Ser Ser Lys Cys Gln Cys Pro Pro Gly Tyr 
225                 230                 235                 240 


His Gly Ser Thr Cys Glu Leu Leu Glu Lys Glu Asp Ser Cys Ala Ser 
                245                 250                 255     


Asn Pro Cys Ser His Gly Val Cys Ile Ser Phe Ser Gly Gly Phe Gln 
            260                 265                 270         


Cys Ile Cys Asp Asp Gly Tyr Ser Gly Ser Tyr Cys Gln Glu Gly Lys 
        275                 280                 285             


Asp Asn Cys Val Asn Asn Lys Cys Glu Ala Gly Ser Lys Cys Ile Asn 
    290                 295                 300                 


Gly Val Asn Ser Tyr Phe Cys Asp Cys Pro Pro Glu Arg Thr Gly Pro 
305                 310                 315                 320 


Tyr Cys Glu Lys Met Asp Cys Ser Ala Ile Pro Asp Ile Cys Asn His 
                325                 330                 335     


Gly Thr Cys Ile Asp Ser Pro Leu Ser Glu Lys Ala Phe Glu Cys Gln 
            340                 345                 350         


Cys Glu Pro Gly Tyr Glu Gly Ile Leu Cys Glu Gln Asp Lys Asn Glu 
        355                 360                 365             


Cys Leu Ser Glu Asn Met Cys Leu Asn Asn Gly Thr Cys Val Asn Leu 
    370                 375                 380                 


Pro Gly Ser Phe Arg Cys Asp Cys Ala Arg Gly Phe Gly Gly Lys Trp 
385                 390                 395                 400 


Cys Asp Glu Pro Leu Asn Met Cys Gln Asp Phe His Cys Glu Asn Asp 
                405                 410                 415     


Gly Thr Cys Met His Thr Ser Asp His Ser Pro Val Cys Gln Cys Lys 
            420                 425                 430         


Asn Gly Phe Ile Gly Lys Arg Cys Glu Lys Glu Cys Pro Ile Gly Phe 
        435                 440                 445             


Gly Gly Val Arg Cys Asp Leu Arg Leu Glu Ile Gly Ile Cys Ser Arg 
    450                 455                 460                 


Gln Gly Gly Lys Cys Phe Asn Gly Gly Lys Cys Leu Ser Gly Phe Cys 
465                 470                 475                 480 


Val Cys Pro Pro Asp Phe Thr Gly Asn Gln Cys Glu Val Asn Arg Lys 
                485                 490                 495     


Asn Gly Lys Ser Ser Leu Ser Glu Asn Leu Cys Leu Ser Asp Pro Cys 
            500                 505                 510         


Met Asn Asn Ala Thr Cys Ile Asp Val Asp Ala His Ile Gly Tyr Ala 
        515                 520                 525             


Cys Ile Cys Lys Gln Gly Phe Glu Gly Asp Ile Cys Glu Arg His Lys 
    530                 535                 540                 


Asp Leu Cys Leu Glu Asn Pro Cys Ser Asn Gly Gly Val Cys His Gln 
545                 550                 555                 560 


His Arg Glu Ser Phe Ser Cys Asp Cys Pro Pro Gly Phe Tyr Gly Asn 
                565                 570                 575     


Gly Cys Glu Gln Glu Lys Met Phe Arg Cys Leu Lys Ser Thr Cys Gln 
            580                 585                 590         


Asn Gly Gly Val Cys Ile Asn Glu Glu Glu Lys Gly Arg Lys Cys Glu 
        595                 600                 605             


Cys Ser Tyr Gly Phe Ser Gly Ala Arg Cys Glu Glu Lys Ile Asn Leu 
    610                 615                 620                 


Thr Gly Phe Thr Glu Lys Asp Ser Leu Leu Arg Ser Val Cys Glu Lys 
625                 630                 635                 640 


Arg Lys Cys Ser Glu Arg Ala Asn Asp Gly Asn Cys Asp Ala Asp Cys 
                645                 650                 655     


Asn Tyr Ala Ala Cys Lys Phe Asp Gly Gly Asp Cys Ser Gly Lys Arg 
            660                 665                 670         


Glu Pro Phe Ser Lys Cys Arg Tyr Gly Asn Met Cys Ala Asp Phe Phe 
        675                 680                 685             


Ala Asn Gly Val Cys Asn Gln Ala Cys Asn Asn Glu Glu Cys Leu Tyr 
    690                 695                 700                 


Asp Gly Met Asp Cys Leu Pro Ala Val Val Arg Cys Pro Val Lys Ile 
705                 710                 715                 720 


Arg Glu His Cys Ala Ser Arg Phe Ala Asn Gly Ile Cys Asp Pro Glu 
                725                 730                 735     


Cys Asn Thr Asn Gly Cys Gly Phe Asp Gly Gly Asp Cys Asp Asn Glu 
            740                 745                 750         


Thr Asn Ala Thr Ile Ile Thr Asn Ile Arg Ile Thr Val Gln Met Asp 
        755                 760                 765             


Pro Lys Glu Phe Gln Val Thr Gly Gly Gln Ser Leu Met Glu Ile Ser 
    770                 775                 780                 


Ser Ala Leu Arg Val Thr Val Arg Ile Gln Arg Asp Glu Glu Gly Pro 
785                 790                 795                 800 


Leu Val Phe Gln Trp Asn Gly Glu Ser Glu Met Asp Arg Val Lys Met 
                805                 810                 815     


Asn Glu Arg Gln Leu Thr Glu Gln His Val Leu Ser Thr Ser Ile Ser 
            820                 825                 830         


Arg Lys Ile Lys Arg Ser Ala Thr Asn Ile Gly Val Val Val Tyr Leu 
        835                 840                 845             


Glu Val Gln Glu Asn Cys Asp Thr Gly Lys Cys Leu Tyr Lys Asp Ala 
    850                 855                 860                 


Gln Ser Val Val Asp Ser Ile Ser Ala Arg Leu Ala Lys Lys Gly Ile 
865                 870                 875                 880 


Asp Ser Phe Gly Ile Pro Ile Ser Glu Ala Leu Val Ala Glu Pro Arg 
                885                 890                 895     


Lys Ser Gly Asn Asn Thr Gly Phe Leu Ser Trp Asn Ala Leu Leu Leu 
            900                 905                 910         


Ile Gly Ala Gly Cys Leu Ile Val Met Val Val Leu Met Leu Gly Ala 
        915                 920                 925             


Leu Pro Gly Asn Arg Thr Arg Lys Arg Arg Met Ile Asn Ala Ser Val 
    930                 935                 940                 


Trp Met Pro Pro Met Glu Asn Glu Glu Lys Asn Arg Lys Asn His Gln 
945                 950                 955                 960 


Ser Ile Thr Ser Ser Gln His Ser Leu Leu Glu Ala Ser Tyr Asp Gly 
                965                 970                 975     


Tyr Ile Lys Arg Gln Arg Asn Glu Leu Gln His Tyr Ser Leu Tyr Pro 
            980                 985                 990         


Asn Pro Gln Gly Tyr Gly Asn Gly  Asn Asp Phe Leu Gly  Asp Phe Asn 
        995                 1000                 1005             


His Thr  Asn Leu Gln Ile Pro  Thr Glu Pro Glu Pro  Glu Ser Pro 
    1010                 1015                 1020             


Ile Lys  Leu His Thr Glu Ala  Ala Gly Ser Tyr Ala  Ile Thr Glu 
    1025                 1030                 1035             


Pro Ile  Thr Arg Glu Ser Val  Asn Ile Ile Asp Pro  Arg His Asn 
    1040                 1045                 1050             


Arg Thr  Val Leu His Trp Ile  Ala Ser Asn Ser Ser  Ala Glu Lys 
    1055                 1060                 1065             


Ser Glu  Asp Leu Ile Val His  Glu Ala Lys Glu Cys  Ile Ala Ala 
    1070                 1075                 1080             


Gly Ala  Asp Val Asn Ala Met  Asp Cys Asp Glu Asn  Thr Pro Leu 
    1085                 1090                 1095             


Met Leu  Ala Val Leu Ala Arg  Arg Arg Arg Leu Val  Ala Tyr Leu 
    1100                 1105                 1110             


Met Lys  Ala Gly Ala Asp Pro  Thr Ile Tyr Asn Lys  Ser Glu Arg 
    1115                 1120                 1125             


Ser Ala  Leu His Gln Ala Ala  Ala Asn Arg Asp Phe  Gly Met Met 
    1130                 1135                 1140             


Val Tyr  Met Leu Asn Ser Thr  Lys Leu Lys Gly Asp  Ile Glu Glu 
    1145                 1150                 1155             


Leu Asp  Arg Asn Gly Met Thr  Ala Leu Met Ile Val  Ala His Asn 
    1160                 1165                 1170             


Glu Gly  Arg Asp Gln Val Ala  Ser Ala Lys Leu Leu  Val Glu Lys 
    1175                 1180                 1185             


Gly Ala  Lys Val Asp Tyr Asp  Gly Ala Ala Arg Lys  Asp Ser Glu 
    1190                 1195                 1200             


Lys Tyr  Lys Gly Arg Thr Ala  Leu His Tyr Ala Ala  Gln Val Ser 
    1205                 1210                 1215             


Asn Met  Pro Ile Val Lys Tyr  Leu Val Gly Glu Lys  Gly Ser Asn 
    1220                 1225                 1230             


Lys Asp  Lys Gln Asp Glu Asp  Gly Lys Thr Pro Ile  Met Leu Ala 
    1235                 1240                 1245             


Ala Gln  Glu Gly Arg Ile Glu  Val Val Met Tyr Leu  Ile Gln Gln 
    1250                 1255                 1260             


Gly Ala  Ser Val Glu Ala Val  Asp Ala Thr Asp His  Thr Ala Arg 
    1265                 1270                 1275             


Gln Leu  Ala Gln Ala Asn Asn  His His Asn Ile Val  Asp Ile Phe 
    1280                 1285                 1290             


Asp Arg  Cys Arg Pro Glu Arg  Glu Tyr Ser Met Asp  Leu His Ile 
    1295                 1300                 1305             


Gln His  Thr His Gln Pro Gln  Pro Ser Arg Lys Val  Thr Arg Ala 
    1310                 1315                 1320             


Pro Lys  Lys Gln Thr Ser Arg  Ser Lys Lys Glu Ser  Ala Ser Asn 
    1325                 1330                 1335             


Ser Arg  Asp Ser Thr His Leu  Thr Pro Pro Pro Ser  Asp Gly Ser 
    1340                 1345                 1350             


Thr Ser  Thr Pro Ser Pro Gln  His Phe Met Asn Thr  Thr His Thr 
    1355                 1360                 1365             


Thr Pro  Thr Ser Leu Asn Tyr  Leu Ser Pro Glu Tyr  Gln Thr Glu 
    1370                 1375                 1380             


Ala Gly  Ser Ser Glu Ala Phe  Gln Pro Gln Cys Gly  Ala Phe Gly 
    1385                 1390                 1395             


Asn Gly  Glu Met Trp Tyr Thr  Arg Ala Ser Thr Ser  Tyr Thr Gln 
    1400                 1405                 1410             


Met Gln  Asn Glu Pro Met Thr  Arg Tyr Ser Glu Pro  Ala His Tyr 
    1415                 1420                 1425             


Phe 
    


<210>  134
<211>  2703
<212>  PRT
<213>  Drosophila melanogaster

<400>  134

Met Gln Ser Gln Arg Ser Arg Arg Arg Ser Arg Ala Pro Asn Thr Trp 
1               5                   10                  15      


Ile Cys Phe Trp Ile Asn Lys Met His Ala Val Ala Ser Leu Pro Ala 
            20                  25                  30          


Ser Leu Pro Leu Leu Leu Leu Thr Leu Ala Phe Ala Asn Leu Pro Asn 
        35                  40                  45              


Thr Val Arg Gly Thr Asp Thr Ala Leu Val Ala Ala Ser Cys Thr Ser 
    50                  55                  60                  


Val Gly Cys Gln Asn Gly Gly Thr Cys Val Thr Gln Leu Asn Gly Lys 
65                  70                  75                  80  


Thr Tyr Cys Ala Cys Asp Ser His Tyr Val Gly Asp Tyr Cys Glu His 
                85                  90                  95      


Arg Asn Pro Cys Asn Ser Met Arg Cys Gln Asn Gly Gly Thr Cys Gln 
            100                 105                 110         


Val Thr Phe Arg Asn Gly Arg Pro Gly Ile Ser Cys Lys Cys Pro Leu 
        115                 120                 125             


Gly Phe Asp Glu Ser Leu Cys Glu Ile Ala Val Pro Asn Ala Cys Asp 
    130                 135                 140                 


His Val Thr Cys Leu Asn Gly Gly Thr Cys Gln Leu Lys Thr Leu Glu 
145                 150                 155                 160 


Glu Tyr Thr Cys Ala Cys Ala Asn Gly Tyr Thr Gly Glu Arg Cys Glu 
                165                 170                 175     


Thr Lys Asn Leu Cys Ala Ser Ser Pro Cys Arg Asn Gly Ala Thr Cys 
            180                 185                 190         


Thr Ala Leu Ala Gly Ser Ser Ser Phe Thr Cys Ser Cys Pro Pro Gly 
        195                 200                 205             


Phe Thr Gly Asp Thr Cys Ser Tyr Asp Ile Glu Glu Cys Gln Ser Asn 
    210                 215                 220                 


Pro Cys Lys Tyr Gly Gly Thr Cys Val Asn Thr His Gly Ser Tyr Gln 
225                 230                 235                 240 


Cys Met Cys Pro Thr Gly Tyr Thr Gly Lys Asp Cys Asp Thr Lys Tyr 
                245                 250                 255     


Lys Pro Cys Ser Pro Ser Pro Cys Gln Asn Gly Gly Ile Cys Arg Ser 
            260                 265                 270         


Asn Gly Leu Ser Tyr Glu Cys Lys Cys Pro Lys Gly Phe Glu Gly Lys 
        275                 280                 285             


Asn Cys Glu Gln Asn Tyr Asp Asp Cys Leu Gly His Leu Cys Gln Asn 
    290                 295                 300                 


Gly Gly Thr Cys Ile Asp Gly Ile Ser Asp Tyr Thr Cys Arg Cys Pro 
305                 310                 315                 320 


Pro Asn Phe Thr Gly Arg Phe Cys Gln Asp Asp Val Asp Glu Cys Ala 
                325                 330                 335     


Gln Arg Asp His Pro Val Cys Gln Asn Gly Ala Thr Cys Thr Asn Thr 
            340                 345                 350         


His Gly Ser Tyr Ser Cys Ile Cys Val Asn Gly Trp Ala Gly Leu Asp 
        355                 360                 365             


Cys Ser Asn Asn Thr Asp Asp Cys Lys Gln Ala Ala Cys Phe Tyr Gly 
    370                 375                 380                 


Ala Thr Cys Ile Asp Gly Val Gly Ser Phe Tyr Cys Gln Cys Thr Lys 
385                 390                 395                 400 


Gly Lys Thr Gly Leu Leu Cys His Leu Asp Asp Ala Cys Thr Ser Asn 
                405                 410                 415     


Pro Cys His Ala Asp Ala Ile Cys Asp Thr Ser Pro Ile Asn Gly Ser 
            420                 425                 430         


Tyr Ala Cys Ser Cys Ala Thr Gly Tyr Lys Gly Val Asp Cys Ser Glu 
        435                 440                 445             


Asp Ile Asp Glu Cys Asp Gln Gly Ser Pro Cys Glu His Asn Gly Ile 
    450                 455                 460                 


Cys Val Asn Thr Pro Gly Ser Tyr Arg Cys Asn Cys Ser Gln Gly Phe 
465                 470                 475                 480 


Thr Gly Pro Arg Cys Glu Thr Asn Ile Asn Glu Cys Glu Ser His Pro 
                485                 490                 495     


Cys Gln Asn Glu Gly Ser Cys Leu Asp Asp Pro Gly Thr Phe Arg Cys 
            500                 505                 510         


Val Cys Met Pro Gly Phe Thr Gly Thr Gln Cys Glu Ile Asp Ile Asp 
        515                 520                 525             


Glu Cys Gln Ser Asn Pro Cys Leu Asn Asp Gly Thr Cys His Asp Lys 
    530                 535                 540                 


Ile Asn Gly Phe Lys Cys Ser Cys Ala Leu Gly Phe Thr Gly Ala Arg 
545                 550                 555                 560 


Cys Gln Ile Asn Ile Asp Asp Cys Gln Ser Gln Pro Cys Arg Asn Arg 
                565                 570                 575     


Gly Ile Cys His Asp Ser Ile Ala Gly Tyr Ser Cys Glu Cys Pro Pro 
            580                 585                 590         


Gly Tyr Thr Gly Thr Ser Cys Glu Ile Asn Ile Asn Asp Cys Asp Ser 
        595                 600                 605             


Asn Pro Cys His Arg Gly Lys Cys Ile Asp Asp Val Asn Ser Phe Lys 
    610                 615                 620                 


Cys Leu Cys Asp Pro Gly Tyr Thr Gly Tyr Ile Cys Gln Lys Gln Ile 
625                 630                 635                 640 


Asn Glu Cys Glu Ser Asn Pro Cys Gln Phe Asp Gly His Cys Gln Asp 
                645                 650                 655     


Arg Val Gly Ser Tyr Tyr Cys Gln Cys Gln Ala Gly Thr Ser Gly Lys 
            660                 665                 670         


Asn Cys Glu Val Asn Val Asn Glu Cys His Ser Asn Pro Cys Asn Asn 
        675                 680                 685             


Gly Ala Thr Cys Ile Asp Gly Ile Asn Ser Tyr Lys Cys Gln Cys Val 
    690                 695                 700                 


Pro Gly Phe Thr Gly Gln His Cys Glu Lys Asn Val Asp Glu Cys Ile 
705                 710                 715                 720 


Ser Ser Pro Cys Ala Asn Asn Gly Val Cys Ile Asp Gln Val Asn Gly 
                725                 730                 735     


Tyr Lys Cys Glu Cys Pro Arg Gly Phe Tyr Asp Ala His Cys Leu Ser 
            740                 745                 750         


Asp Val Asp Glu Cys Ala Ser Asn Pro Cys Val Asn Glu Gly Arg Cys 
        755                 760                 765             


Glu Asp Gly Ile Asn Glu Phe Ile Cys His Cys Pro Pro Gly Tyr Thr 
    770                 775                 780                 


Gly Lys Arg Cys Glu Leu Asp Ile Asp Glu Cys Ser Ser Asn Pro Cys 
785                 790                 795                 800 


Gln His Gly Gly Thr Cys Tyr Asp Lys Leu Asn Ala Phe Ser Cys Gln 
                805                 810                 815     


Cys Met Pro Gly Tyr Thr Gly Gln Lys Cys Glu Thr Asn Ile Asp Asp 
            820                 825                 830         


Cys Val Thr Asn Pro Cys Gly Asn Gly Gly Thr Cys Ile Asp Lys Val 
        835                 840                 845             


Asn Gly Tyr Lys Cys Val Cys Lys Val Pro Phe Thr Gly Arg Asp Cys 
    850                 855                 860                 


Glu Ser Lys Met Asp Pro Cys Ala Ser Asn Arg Cys Lys Asn Glu Ala 
865                 870                 875                 880 


Lys Cys Thr Pro Ser Ser Asn Phe Leu Asp Phe Ser Cys Thr Cys Lys 
                885                 890                 895     


Leu Gly Tyr Thr Gly Arg Tyr Cys Asp Glu Asp Ile Asp Glu Cys Ser 
            900                 905                 910         


Leu Ser Ser Pro Cys Arg Asn Gly Ala Ser Cys Leu Asn Val Pro Gly 
        915                 920                 925             


Ser Tyr Arg Cys Leu Cys Thr Lys Gly Tyr Glu Gly Arg Asp Cys Ala 
    930                 935                 940                 


Ile Asn Thr Asp Asp Cys Ala Ser Phe Pro Cys Gln Asn Gly Gly Thr 
945                 950                 955                 960 


Cys Leu Asp Gly Ile Gly Asp Tyr Ser Cys Leu Cys Val Asp Gly Phe 
                965                 970                 975     


Asp Gly Lys His Cys Glu Thr Asp Ile Asn Glu Cys Leu Ser Gln Pro 
            980                 985                 990         


Cys Gln Asn Gly Ala Thr Cys Ser  Gln Tyr Val Asn Ser  Tyr Thr Cys 
        995                 1000                 1005             


Thr Cys  Pro Leu Gly Phe Ser  Gly Ile Asn Cys Gln  Thr Asn Asp 
    1010                 1015                 1020             


Glu Asp  Cys Thr Glu Ser Ser  Cys Leu Asn Gly Gly  Ser Cys Ile 
    1025                 1030                 1035             


Asp Gly  Ile Asn Gly Tyr Asn  Cys Ser Cys Leu Ala  Gly Tyr Ser 
    1040                 1045                 1050             


Gly Ala  Asn Cys Gln Tyr Lys  Leu Asn Lys Cys Asp  Ser Asn Pro 
    1055                 1060                 1065             


Cys Leu  Asn Gly Ala Thr Cys  His Glu Gln Asn Asn  Glu Tyr Thr 
    1070                 1075                 1080             


Cys His  Cys Pro Ser Gly Phe  Thr Gly Lys Gln Cys  Ser Glu Tyr 
    1085                 1090                 1095             


Val Asp  Trp Cys Gly Gln Ser  Pro Cys Glu Asn Gly  Ala Thr Cys 
    1100                 1105                 1110             


Ser Gln  Met Lys His Gln Phe  Ser Cys Lys Cys Ser  Ala Gly Trp 
    1115                 1120                 1125             


Thr Gly  Lys Leu Cys Asp Val  Gln Thr Ile Ser Cys  Gln Asp Ala 
    1130                 1135                 1140             


Ala Asp  Arg Lys Gly Leu Ser  Leu Arg Gln Leu Cys  Asn Asn Gly 
    1145                 1150                 1155             


Thr Cys  Lys Asp Tyr Gly Asn  Ser His Val Cys Tyr  Cys Ser Gln 
    1160                 1165                 1170             


Gly Tyr  Ala Gly Ser Tyr Cys  Gln Lys Glu Ile Asp  Glu Cys Gln 
    1175                 1180                 1185             


Ser Gln  Pro Cys Gln Asn Gly  Gly Thr Cys Arg Asp  Leu Ile Gly 
    1190                 1195                 1200             


Ala Tyr  Glu Cys Gln Cys Arg  Gln Gly Phe Gln Gly  Gln Asn Cys 
    1205                 1210                 1215             


Glu Leu  Asn Ile Asp Asp Cys  Ala Pro Asn Pro Cys  Gln Asn Gly 
    1220                 1225                 1230             


Gly Thr  Cys His Asp Arg Val  Met Asn Phe Ser Cys  Ser Cys Pro 
    1235                 1240                 1245             


Pro Gly  Thr Met Gly Ile Ile  Cys Glu Ile Asn Lys  Asp Asp Cys 
    1250                 1255                 1260             


Lys Pro  Gly Ala Cys His Asn  Asn Gly Ser Cys Ile  Asp Arg Val 
    1265                 1270                 1275             


Gly Gly  Phe Glu Cys Val Cys  Gln Pro Gly Phe Val  Gly Ala Arg 
    1280                 1285                 1290             


Cys Glu  Gly Asp Ile Asn Glu  Cys Leu Ser Asn Pro  Cys Ser Asn 
    1295                 1300                 1305             


Ala Gly  Thr Leu Asp Cys Val  Gln Leu Val Asn Asn  Tyr His Cys 
    1310                 1315                 1320             


Asn Cys  Arg Pro Gly His Met  Gly Arg His Cys Glu  His Lys Val 
    1325                 1330                 1335             


Asp Phe  Cys Ala Gln Ser Pro  Cys Gln Asn Gly Gly  Asn Cys Asn 
    1340                 1345                 1350             


Ile Arg  Gln Ser Gly His His  Cys Ile Cys Asn Asn  Gly Phe Tyr 
    1355                 1360                 1365             


Gly Lys  Asn Cys Glu Leu Ser  Gly Gln Asp Cys Asp  Ser Asn Pro 
    1370                 1375                 1380             


Cys Arg  Val Gly Asn Cys Val  Val Ala Asp Glu Gly  Phe Gly Tyr 
    1385                 1390                 1395             


Arg Cys  Glu Cys Pro Arg Gly  Thr Leu Gly Glu His  Cys Glu Ile 
    1400                 1405                 1410             


Asp Thr  Leu Asp Glu Cys Ser  Pro Asn Pro Cys Ala  Gln Gly Ala 
    1415                 1420                 1425             


Ala Cys  Glu Asp Leu Leu Gly  Asp Tyr Glu Cys Leu  Cys Pro Ser 
    1430                 1435                 1440             


Lys Trp  Lys Gly Lys Arg Cys  Asp Ile Tyr Asp Ala  Asn Tyr Pro 
    1445                 1450                 1455             


Gly Trp  Asn Gly Gly Ser Gly  Ser Gly Asn Asp Arg  Tyr Ala Ala 
    1460                 1465                 1470             


Asp Leu  Glu Gln Gln Arg Ala  Met Cys Asp Lys Arg  Gly Cys Thr 
    1475                 1480                 1485             


Glu Lys  Gln Gly Asn Gly Ile  Cys Asp Ser Asp Cys  Asn Thr Tyr 
    1490                 1495                 1500             


Ala Cys  Asn Phe Asp Gly Asn  Asp Cys Ser Leu Gly  Ile Asn Pro 
    1505                 1510                 1515             


Trp Ala  Asn Cys Thr Ala Asn  Glu Cys Trp Asn Lys  Phe Lys Asn 
    1520                 1525                 1530             


Gly Lys  Cys Asn Glu Glu Cys  Asn Asn Ala Ala Cys  His Tyr Asp 
    1535                 1540                 1545             


Gly His  Asp Cys Glu Arg Lys  Leu Lys Ser Cys Asp  Ser Leu Phe 
    1550                 1555                 1560             


Asp Ala  Tyr Cys Gln Lys His  Tyr Gly Asp Gly Phe  Cys Asp Tyr 
    1565                 1570                 1575             


Gly Cys  Asn Asn Ala Glu Cys  Ser Trp Asp Gly Leu  Asp Cys Glu 
    1580                 1585                 1590             


Asn Lys  Thr Gln Ser Pro Val  Leu Ala Glu Gly Ala  Met Ser Val 
    1595                 1600                 1605             


Val Met  Leu Met Asn Val Glu  Ala Phe Arg Glu Ile  Gln Ala Gln 
    1610                 1615                 1620             


Phe Leu  Arg Asn Met Ser His  Met Leu Arg Thr Thr  Val Arg Leu 
    1625                 1630                 1635             


Lys Lys  Asp Ala Leu Gly His  Asp Ile Ile Ile Asn  Trp Lys Asp 
    1640                 1645                 1650             


Asn Val  Arg Val Pro Glu Ile  Glu Asp Thr Asp Phe  Ala Arg Lys 
    1655                 1660                 1665             


Asn Lys  Ile Leu Tyr Thr Gln  Gln Val His Gln Thr  Gly Ile Gln 
    1670                 1675                 1680             


Ile Tyr  Leu Glu Ile Asp Asn  Arg Lys Cys Thr Glu  Cys Phe Thr 
    1685                 1690                 1695             


His Ala  Val Glu Ala Ala Glu  Phe Leu Ala Ala Thr  Ala Ala Lys 
    1700                 1705                 1710             


His Gln  Leu Arg Asn Asp Phe  Gln Ile His Ser Val  Arg Gly Ile 
    1715                 1720                 1725             


Lys Asn  Pro Gly Asp Glu Asp  Asn Gly Glu Pro Pro  Ala Asn Val 
    1730                 1735                 1740             


Lys Tyr  Val Ile Thr Gly Ile  Ile Leu Val Ile Ile  Ala Leu Ala 
    1745                 1750                 1755             


Phe Phe  Gly Met Val Leu Ser  Thr Gln Arg Lys Arg  Ala His Gly 
    1760                 1765                 1770             


Val Thr  Trp Phe Pro Glu Gly  Phe Arg Ala Pro Ala  Ala Val Met 
    1775                 1780                 1785             


Ser Arg  Arg Arg Arg Asp Pro  His Gly Gln Glu Met  Arg Asn Leu 
    1790                 1795                 1800             


Asn Lys  Gln Val Ala Met Gln  Ser Gln Gly Val Gly  Gln Pro Gly 
    1805                 1810                 1815             


Ala His  Trp Ser Asp Asp Glu  Ser Asp Met Pro Leu  Pro Lys Arg 
    1820                 1825                 1830             


Gln Arg  Ser Asp Pro Val Ser  Gly Val Gly Leu Gly  Asn Asn Gly 
    1835                 1840                 1845             


Gly Tyr  Ala Ser Asp His Thr  Met Val Ser Glu Tyr  Glu Glu Ala 
    1850                 1855                 1860             


Asp Gln  Arg Val Trp Ser Gln  Ala His Leu Asp Val  Val Asp Val 
    1865                 1870                 1875             


Arg Ala  Ile Met Thr Pro Pro  Ala His Gln Asp Gly  Gly Lys His 
    1880                 1885                 1890             


Asp Val  Asp Ala Arg Gly Pro  Cys Gly Leu Thr Pro  Leu Met Ile 
    1895                 1900                 1905             


Ala Ala  Val Arg Gly Gly Gly  Leu Asp Thr Gly Glu  Asp Ile Glu 
    1910                 1915                 1920             


Asn Asn  Glu Asp Ser Thr Ala  Gln Val Ile Ser Asp  Leu Leu Ala 
    1925                 1930                 1935             


Gln Gly  Ala Glu Leu Asn Ala  Thr Met Asp Lys Thr  Gly Glu Thr 
    1940                 1945                 1950             


Ser Leu  His Leu Ala Ala Arg  Phe Ala Arg Ala Asp  Ala Ala Lys 
    1955                 1960                 1965             


Arg Leu  Leu Asp Ala Gly Ala  Asp Ala Asn Cys Gln  Asp Asn Thr 
    1970                 1975                 1980             


Gly Arg  Thr Pro Leu His Ala  Ala Val Ala Ala Asp  Ala Met Gly 
    1985                 1990                 1995             


Val Phe  Gln Ile Leu Leu Arg  Asn Arg Ala Thr Asn  Leu Asn Ala 
    2000                 2005                 2010             


Arg Met  His Asp Gly Thr Thr  Pro Leu Ile Leu Ala  Ala Arg Leu 
    2015                 2020                 2025             


Ala Ile  Glu Gly Met Val Glu  Asp Leu Ile Thr Ala  Asp Ala Asp 
    2030                 2035                 2040             


Ile Asn  Ala Ala Asp Asn Ser  Gly Lys Thr Ala Leu  His Trp Ala 
    2045                 2050                 2055             


Ala Ala  Val Asn Asn Thr Glu  Ala Val Asn Ile Leu  Leu Met His 
    2060                 2065                 2070             


His Ala  Asn Arg Asp Ala Gln  Asp Asp Lys Asp Glu  Thr Pro Leu 
    2075                 2080                 2085             


Phe Leu  Ala Ala Arg Glu Gly  Ser Tyr Glu Ala Cys  Lys Ala Leu 
    2090                 2095                 2100             


Leu Asp  Asn Phe Ala Asn Arg  Glu Ile Thr Asp His  Met Asp Arg 
    2105                 2110                 2115             


Leu Pro  Arg Asp Val Ala Ser  Glu Arg Leu His His  Asp Ile Val 
    2120                 2125                 2130             


Arg Leu  Leu Asp Glu His Val  Pro Arg Ser Pro Gln  Met Leu Ser 
    2135                 2140                 2145             


Met Thr  Pro Gln Ala Met Ile  Gly Ser Pro Pro Pro  Gly Gln Gln 
    2150                 2155                 2160             


Gln Pro  Gln Leu Ile Thr Gln  Pro Thr Val Ile Ser  Ala Gly Asn 
    2165                 2170                 2175             


Gly Gly  Asn Asn Gly Asn Gly  Asn Ala Ser Gly Lys  Gln Ser Asn 
    2180                 2185                 2190             


Gln Thr  Ala Lys Gln Lys Ala  Ala Lys Lys Ala Lys  Leu Ile Glu 
    2195                 2200                 2205             


Gly Ser  Pro Asp Asn Gly Leu  Asp Ala Thr Gly Ser  Leu Arg Arg 
    2210                 2215                 2220             


Lys Ala  Ser Ser Lys Lys Thr  Ser Ala Ala Ser Lys  Lys Ala Ala 
    2225                 2230                 2235             


Asn Leu  Asn Gly Leu Asn Pro  Gly Gln Leu Thr Gly  Gly Val Ser 
    2240                 2245                 2250             


Gly Val  Pro Gly Val Pro Pro  Thr Asn Ser Ala Ala  Gln Ala Ala 
    2255                 2260                 2265             


Ala Ala  Ala Ala Ala Ala Val  Ala Ala Met Ser His  Glu Leu Glu 
    2270                 2275                 2280             


Gly Ser  Pro Val Gly Val Gly  Met Gly Gly Asn Leu  Pro Ser Pro 
    2285                 2290                 2295             


Tyr Asp  Thr Ser Ser Met Tyr  Ser Asn Ala Met Ala  Ala Pro Leu 
    2300                 2305                 2310             


Ala Asn  Gly Asn Pro Asn Thr  Gly Ala Lys Gln Pro  Pro Ser Tyr 
    2315                 2320                 2325             


Glu Asp  Cys Ile Lys Asn Ala  Gln Ser Met Gln Ser  Leu Gln Gly 
    2330                 2335                 2340             


Asn Gly  Leu Asp Met Ile Lys  Leu Asp Asn Tyr Ala  Tyr Ser Met 
    2345                 2350                 2355             


Gly Ser  Pro Phe Gln Gln Glu  Leu Leu Asn Gly Gln  Gly Leu Gly 
    2360                 2365                 2370             


Met Asn  Gly Asn Gly Gln Arg  Asn Gly Val Gly Pro  Gly Val Leu 
    2375                 2380                 2385             


Pro Gly  Gly Leu Cys Gly Met  Gly Gly Leu Ser Gly  Ala Gly Asn 
    2390                 2395                 2400             


Gly Asn  Ser His Glu Gln Gly  Leu Ser Pro Pro Tyr  Ser Asn Gln 
    2405                 2410                 2415             


Ser Pro  Pro His Ser Val Gln  Ser Ser Leu Ala Leu  Ser Pro His 
    2420                 2425                 2430             


Ala Tyr  Leu Gly Ser Pro Ser  Pro Ala Lys Ser Arg  Pro Ser Leu 
    2435                 2440                 2445             


Pro Thr  Ser Pro Thr His Ile  Gln Ala Met Arg His  Ala Thr Gln 
    2450                 2455                 2460             


Gln Lys  Gln Phe Gly Gly Ser  Asn Leu Asn Ser Leu  Leu Gly Gly 
    2465                 2470                 2475             


Ala Asn  Gly Gly Gly Val Val  Gly Gly Gly Gly Gly  Gly Gly Gly 
    2480                 2485                 2490             


Gly Val  Gly Gln Gly Pro Gln  Asn Ser Pro Val Ser  Leu Gly Ile 
    2495                 2500                 2505             


Ile Ser  Pro Thr Gly Ser Asp  Met Gly Ile Met Leu  Ala Pro Pro 
    2510                 2515                 2520             


Gln Ser  Ser Lys Asn Ser Ala  Ile Met Gln Thr Ile  Ser Pro Gln 
    2525                 2530                 2535             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  His Gln Gln 
    2540                 2545                 2550             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2555                 2560                 2565             


Leu Gly  Gly Leu Glu Phe Gly  Ser Ala Gly Leu Asp  Leu Asn Gly 
    2570                 2575                 2580             


Phe Cys  Gly Ser Pro Asp Ser  Phe His Ser Gly Gln  Met Asn Pro 
    2585                 2590                 2595             


Pro Ser  Ile Gln Ser Ser Met  Ser Gly Ser Ser Pro  Ser Thr Asn 
    2600                 2605                 2610             


Met Leu  Ser Pro Ser Ser Gln  His Asn Gln Gln Ala  Phe Tyr Gln 
    2615                 2620                 2625             


Tyr Leu  Thr Pro Ser Ser Gln  His Ser Gly Gly His  Thr Pro Gln 
    2630                 2635                 2640             


His Leu  Val Gln Thr Leu Asp  Ser Tyr Pro Thr Pro  Ser Pro Glu 
    2645                 2650                 2655             


Ser Pro  Gly His Trp Ser Ser  Ser Ser Pro Arg Ser  Asn Ser Asp 
    2660                 2665                 2670             


Trp Ser  Glu Gly Val Gln Ser  Pro Ala Ala Asn Asn  Leu Tyr Ile 
    2675                 2680                 2685             


Ser Gly  Gly His Gln Ala Asn  Lys Gly Ser Glu Ala  Ile Tyr Ile 
    2690                 2695                 2700             


<210>  135
<211>  2900
<212>  PRT
<213>  Bos taurus

<400>  135

Met Thr Pro Val Cys Thr Pro Thr Arg Pro Gly Pro Cys Ala His Pro 
1               5                   10                  15      


Ala Leu Pro Arg Ser Thr Pro His Ser Ile Thr Asp Ser Ser Arg Ala 
            20                  25                  30          


Glu Pro Ile Glu Ser Phe Leu Val Leu Ser Pro Ala Leu Glu Leu Arg 
        35                  40                  45              


Leu Leu Leu Ala Val Val Gly Gln Asp Thr Pro Leu Gly Asp Val Trp 
    50                  55                  60                  


Ala Gly Gly Lys Ala Ser Gly Gly Gly Asp Thr Glu Gly Pro Leu Ser 
65                  70                  75                  80  


Glu Gly Ser Lys Glu Gly Glu Ala Ala Thr Gly Pro Gln Ala Pro Gly 
                85                  90                  95      


Ala Glu Trp His Ala Pro Pro Arg Ser Thr Cys Leu Ser Ser Thr Pro 
            100                 105                 110         


Arg Pro Glu Ala Val Pro Pro Ser Leu Pro Cys Arg Ser Pro Gly Trp 
        115                 120                 125             


Gly Ala Cys Gly Gly Arg Arg Pro Gly Pro Ala Leu Glu Pro Ala His 
    130                 135                 140                 


Met Gly Ser Val Pro Ser Gln Gln Arg Pro Pro Gly Leu Asp Arg Ser 
145                 150                 155                 160 


Arg Glu Asp Asn Gly Pro Pro Gln Pro Leu Pro Ser Pro His Gly Gly 
                165                 170                 175     


Ala Ser Leu Ala Pro Ala Pro Pro Pro Ala Cys Arg Gly Trp Gln Pro 
            180                 185                 190         


Pro Leu Arg Trp Pro Gly Ala Ala Ala Ala Arg Val Pro Gly His Arg 
        195                 200                 205             


Arg Thr Cys Ser Pro Ala Ala Leu Cys Pro Cys Cys Arg Cys Leu Ile 
    210                 215                 220                 


Tyr Trp Ala Arg Phe Ser Ser His Cys Asn Ser Arg Ser Leu Pro Gly 
225                 230                 235                 240 


Gln Asp Ala Leu Gly Pro Gly Leu Trp Val Pro Ser Ala Thr Gln Ala 
                245                 250                 255     


Gly Thr Arg Gln Pro Val Thr Gly Ser Thr Leu Ser Gly Gly His Ala 
            260                 265                 270         


Thr Phe Pro Arg Leu Gln Gly Met Ala Leu Pro Glu Pro Glu Gly Glu 
        275                 280                 285             


Gly Pro Pro Thr Thr Ser Ala Gln Gly Cys Gly Pro Ser Val Arg Ala 
    290                 295                 300                 


Ala Phe Pro Gly Arg Cys Gln Leu Gly Ala Val Gly Ala Phe His Pro 
305                 310                 315                 320 


Arg Gly Ser Ala Ala Gly Lys Arg Glu Ala Trp Leu Val Pro Glu Pro 
                325                 330                 335     


Leu Leu Gly Phe Pro Ser Ser Ser Arg Leu Arg Gly Asp Pro Gly Gly 
            340                 345                 350         


His Val Pro Pro Arg Leu Lys Lys Pro Arg Gln Gln Val Ala Lys Gly 
        355                 360                 365             


Gly Pro Gly Ala Gly Val Ala Gly Ala Glu Pro Phe Pro Val Gly Ser 
    370                 375                 380                 


Ala Gly Asp Gln Ala Trp Gly Trp Ala Gly Gly Lys Ala Pro Pro Thr 
385                 390                 395                 400 


Pro Gly Ser Pro Ala Thr Val Ala Ala Arg Glu Pro Ala Gln Gly Leu 
                405                 410                 415     


Pro Asp Cys Gly Gly Ala Phe Ala Gly Gln Gln Cys Gln Ala Pro Asn 
            420                 425                 430         


Pro Cys Leu Ser Ala Pro Cys Lys Asn Gly Gly Thr Cys His Thr Thr 
        435                 440                 445             


Glu Arg Glu Gly Leu Val Asp Tyr Val Cys Gly Cys Arg Leu Gly Phe 
    450                 455                 460                 


Ser Gly Pro Leu Cys Leu Thr Pro Arg Asp His Ala Cys Leu Ala Ser 
465                 470                 475                 480 


Pro Cys Leu Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr 
                485                 490                 495     


Lys Cys Leu Cys Thr Pro Gly Trp Ser Gly Lys Thr Cys Gln Gln Ala 
            500                 505                 510         


Asp Pro Cys Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro 
        515                 520                 525             


Phe Glu Ala Ser Tyr Ile Cys His Cys Pro Pro Gly Phe His Gly Pro 
    530                 535                 540                 


Thr Cys Arg Gln Asp Val Asn Glu Cys Ser Gln Ser Pro Gly Leu Cys 
545                 550                 555                 560 


His His Gly Gly Thr Cys Leu Asn Glu Val Gly Ser Tyr Arg Cys Val 
                565                 570                 575     


Cys Arg Pro Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro 
            580                 585                 590         


Cys Ser Pro Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly 
        595                 600                 605             


Asp Thr Thr His Glu Cys Ala Cys Leu Pro Gly Phe Thr Gly Gln Asn 
    610                 615                 620                 


Cys Glu Glu Asn Ile Asp Asp Cys Pro Gly Asn Ser Cys Lys Asn Gly 
625                 630                 635                 640 


Gly Ala Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
                645                 650                 655     


Glu Trp Thr Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu 
            660                 665                 670         


Met Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys His Asn Thr His Gly 
        675                 680                 685             


Gly Tyr Asn Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser 
    690                 695                 700                 


Glu Asn Ile Asp Asp Cys Ala Ser Ala Ser Cys Phe Gln Gly Ala Thr 
705                 710                 715                 720 


Cys His Asp Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg 
                725                 730                 735     


Thr Gly Leu Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys 
            740                 745                 750         


Asn Glu Gly Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile 
        755                 760                 765             


Cys Thr Cys Pro Ser Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val 
    770                 775                 780                 


Asp Glu Cys Ser Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys 
785                 790                 795                 800 


Ile Asn Thr Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr 
                805                 810                 815     


Gly Pro Arg Cys Glu Ile Asp Val Asn Glu Cys Val Ser Asn Pro Cys 
            820                 825                 830         


Gln Asn Asp Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile 
        835                 840                 845             


Cys Met Pro Gly Tyr Glu Gly Leu His Cys Glu Val Asn Thr Asp Glu 
    850                 855                 860                 


Cys Ala Ser Ser Pro Cys Leu Gln Asn Gly Arg Cys Leu Asp Lys Ile 
865                 870                 875                 880 


Asn Glu Phe Val Cys Glu Cys Pro Thr Gly Phe Thr Gly His Leu Cys 
                885                 890                 895     


Gln Tyr Asp Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala 
            900                 905                 910         


Lys Cys Leu Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly 
        915                 920                 925             


Tyr Thr Gly Pro His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp 
    930                 935                 940                 


Pro Cys His Tyr Gly Ser Cys Lys Asp Gly Val Ala Thr Phe Thr Cys 
945                 950                 955                 960 


Leu Cys Gln Pro Gly Tyr Thr Gly His His Cys Glu Ser Asn Ile Asn 
                965                 970                 975     


Glu Cys His Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg 
            980                 985                 990         


Asp Asn Ala Tyr Leu Cys Phe Cys  Leu Lys Gly Thr Thr  Gly Pro Asn 
        995                 1000                 1005             


Cys Glu  Ile Asn Leu Asp Asp  Cys Ala Ser Asn Pro  Cys Asp Ser 
    1010                 1015                 1020             


Gly Thr  Cys Leu Asp Lys Ile  Asp Gly Tyr Glu Cys  Ala Cys Glu 
    1025                 1030                 1035             


Pro Gly  Tyr Thr Gly Ser Met  Cys Asn Ile Asn Ile  Asp Glu Cys 
    1040                 1045                 1050             


Ala Asp  Ser Pro Cys His Asn  Gly Gly Thr Cys Glu  Asp Gly Ile 
    1055                 1060                 1065             


Asn Gly  Phe Thr Cys Arg Cys  Pro Glu Gly Tyr His  Asp Pro Thr 
    1070                 1075                 1080             


Cys Leu  Ser Glu Val Asn Glu  Cys Ser Ser Asn Pro  Cys Ile His 
    1085                 1090                 1095             


Gly Ala  Cys Arg Asp Ser Leu  Asn Gly Tyr Lys Cys  Asp Cys Asp 
    1100                 1105                 1110             


Pro Gly  Trp Ser Gly Ala Asn  Cys Asp Val Asn Asn  Asp Glu Cys 
    1115                 1120                 1125             


Glu Ser  Asn Pro Cys Ile Asn  Gly Gly Thr Cys Lys  Asp Met Thr 
    1130                 1135                 1140             


Ser Gly  Tyr Val Cys Ala Cys  Arg Glu Gly Phe Ser  Gly Pro Asn 
    1145                 1150                 1155             


Cys Gln  Thr Asn Ile Asn Glu  Cys Ala Ser Asn Pro  Cys Leu Asn 
    1160                 1165                 1170             


Gln Gly  Thr Cys Ile Asp Asp  Val Ala Gly Tyr Lys  Cys Asn Cys 
    1175                 1180                 1185             


Leu Leu  Pro Tyr Thr Gly Ala  Thr Cys Glu Val Val  Leu Ala Pro 
    1190                 1195                 1200             


Cys Ala  Pro Gly Pro Cys Arg  Asn Gly Gly Glu Cys  Arg Glu Ser 
    1205                 1210                 1215             


Glu Asp  Tyr Glu Ser Phe Ser  Cys Ala Cys Pro Ala  Gly Trp Gln 
    1220                 1225                 1230             


Gly Gln  Thr Cys Glu Ile Asp  Ile Asn Glu Cys Val  Lys Ser Pro 
    1235                 1240                 1245             


Cys Arg  Ala Gly Ala Ser Cys  Gln Asn Thr Asn Gly  Ser Tyr Arg 
    1250                 1255                 1260             


Cys His  Cys Gln Ala Gly Tyr  Thr Gly Arg Asn Cys  Glu Thr Asp 
    1265                 1270                 1275             


Ile Asp  Asp Cys Arg Pro Asn  Pro Cys His Asn Gly  Gly Ser Cys 
    1280                 1285                 1290             


Thr Asp  Gly Ile Asn Thr Ala  Phe Cys Asp Cys Leu  Pro Gly Phe 
    1295                 1300                 1305             


Gln Gly  Ala Phe Cys Glu Glu  Asp Ile Asn Glu Cys  Ala Ser Ser 
    1310                 1315                 1320             


Pro Cys  Arg Asn Gly Ala Asn  Cys Thr Asp Cys Val  Asp Ser Tyr 
    1325                 1330                 1335             


Thr Cys  Thr Cys Pro Thr Gly  Phe Ser Gly Ile His  Cys Glu Asn 
    1340                 1345                 1350             


Asn Thr  Pro Asp Cys Thr Glu  Ser Ser Cys Phe Asn  Gly Gly Thr 
    1355                 1360                 1365             


Cys Val  Asp Gly Ile Asn Ser  Phe Thr Cys Leu Cys  Pro Pro Gly 
    1370                 1375                 1380             


Phe Thr  Gly Ser Tyr Cys Gln  His Asp Val Asn Glu  Cys Asp Ser 
    1385                 1390                 1395             


Arg Pro  Cys Leu His Gly Gly  Thr Cys His Asp Ser  Tyr Gly Thr 
    1400                 1405                 1410             


Tyr Thr  Cys Thr Cys Pro Gln  Gly Tyr Thr Gly Leu  Asn Cys Gln 
    1415                 1420                 1425             


Thr Leu  Val Arg Trp Cys Asp  Ser Ser Pro Cys Lys  Asn Asp Gly 
    1430                 1435                 1440             


Arg Cys  Trp Gln Thr Asn Ala  Leu Tyr Arg Cys Glu  Cys His Ser 
    1445                 1450                 1455             


Gly Trp  Thr Gly Leu Tyr Cys  Asp Val Pro Ser Val  Ser Cys Glu 
    1460                 1465                 1470             


Val Ala  Ala Arg Gln Gln Gly  Val Asn Val Thr His  Leu Cys Arg 
    1475                 1480                 1485             


Asn Gly  Gly Leu Cys Met Asn  Ala Gly Asn Thr His  Arg Cys His 
    1490                 1495                 1500             


Cys Gln  Ala Gly Tyr Thr Gly  Ser Tyr Cys Glu Glu  Gln Val Asp 
    1505                 1510                 1515             


Glu Cys  Ser Pro Ser Pro Cys  Gln Asn Gly Ala Thr  Cys Thr Asp 
    1520                 1525                 1530             


Tyr Pro  Gly Gly Tyr Ser Cys  Glu Cys Val Ala Gly  Tyr His Gly 
    1535                 1540                 1545             


Val Asn  Cys Ser Glu Glu Val  Asn Glu Cys Leu Ser  Gln Pro Cys 
    1550                 1555                 1560             


Arg Asn  Gly Gly Thr Cys Ile  Asp Leu Thr Asn Thr  Tyr Lys Cys 
    1565                 1570                 1575             


Ser Cys  Pro Arg Gly Thr Gln  Gly Val His Cys Glu  Ile Asn Val 
    1580                 1585                 1590             


Asp Asp  Cys Asn Pro Pro Ile  Asp Pro Val Ser Arg  Gly Pro Lys 
    1595                 1600                 1605             


Cys Phe  Asn Asn Gly Thr Cys  Val Asp Gln Val Gly  Gly Tyr Ser 
    1610                 1615                 1620             


Cys Ser  Cys Pro Pro Gly Phe  Val Gly Glu Arg Cys  Glu Gly Asp 
    1625                 1630                 1635             


Val Asn  Glu Cys Leu Ser Asn  Pro Cys Asp Ala Arg  Gly Thr Gln 
    1640                 1645                 1650             


Asn Cys  Val Gln His Val Asn  Ala Phe His Cys Glu  Cys Arg Ala 
    1655                 1660                 1665             


Gly His  Thr Gly Arg Arg Cys  Glu Ser Val Ile Asn  Gly Cys Lys 
    1670                 1675                 1680             


Asp Arg  Pro Cys Lys Asn Gly  Gly Ser Cys Ala Val  Ala Ser Asn 
    1685                 1690                 1695             


Thr Ala  Arg Gly Phe Ile Cys  Lys Cys Pro Ala Gly  Phe Glu Gly 
    1700                 1705                 1710             


Ala Thr  Cys Glu Asn Asp Ala  Arg Ser Cys Gly Ser  Leu Arg Cys 
    1715                 1720                 1725             


Leu Asn  Gly Gly Thr Cys Ile  Ala Gly Pro Arg Ser  Pro Thr Cys 
    1730                 1735                 1740             


Leu Cys  Leu Gly Pro Phe Thr  Gly Pro Glu Cys Gln  Phe Pro Ala 
    1745                 1750                 1755             


Ser Ser  Pro Cys Val Gly Gly  Asn Pro Cys Tyr Asn  Gln Gly Val 
    1760                 1765                 1770             


Cys Glu  Pro Thr Ala Glu Ser  Pro Phe Tyr Arg Cys  Arg Cys Pro 
    1775                 1780                 1785             


Ala Lys  Phe Asn Gly Leu Leu  Cys His Ile Leu Asp  Tyr Ser Phe 
    1790                 1795                 1800             


Gly Gly  Gly Val Gly Leu Asp  Ile Pro Pro Pro Gln  Ile Glu Glu 
    1805                 1810                 1815             


Thr Cys  Glu Leu Pro Gly Cys  Arg Glu Glu Ala Gly  Asn Lys Val 
    1820                 1825                 1830             


Cys Ser  Leu Gln Cys Asn Ser  His Ala Cys Gly Trp  Asp Gly Gly 
    1835                 1840                 1845             


Asp Cys  Ser Leu Asp Phe Asp  Asp Pro Trp Gln Asn  Cys Thr Gln 
    1850                 1855                 1860             


Ser Leu  Gln Cys Trp Lys Tyr  Phe Ser Asn Gly Arg  Cys Asp Ser 
    1865                 1870                 1875             


Gln Cys  Asn Ser Ala Gly Cys  Leu Phe Asp Gly Phe  Asp Cys Gln 
    1880                 1885                 1890             


Arg Ala  Glu Gly Gln Cys Asn  Pro Leu Tyr Asp Gln  Tyr Cys Lys 
    1895                 1900                 1905             


Asp His  Phe Arg Asp Gly His  Cys Asp Gln Gly Cys  Asn Ser Ala 
    1910                 1915                 1920             


Glu Cys  Glu Trp Asp Gly Leu  Asp Cys Ala Glu His  Val Pro Glu 
    1925                 1930                 1935             


Arg Leu  Ala Ala Gly Thr Leu  Val Leu Val Val Leu  Met Pro Pro 
    1940                 1945                 1950             


Glu Gln  Leu Arg Asn Arg Ser  Leu His Phe Leu Arg  Glu Leu Ser 
    1955                 1960                 1965             


Arg Leu  Leu His Thr Asn Val  Val Phe Lys Arg Asp  Ala Ser Gly 
    1970                 1975                 1980             


Gln Gln  Met Ile Phe Pro Tyr  Tyr Gly Arg Ala Pro  Leu Pro Ala 
    1985                 1990                 1995             


Gly Glu  Arg Ser Glu Glu Cys  Arg Cys Glu His His  Ala Cys Pro 
    2000                 2005                 2010             


Ala Gly  Ala Gly Gln Gly Glu  Pro Ser Gly Pro Leu  Cys Thr Ser 
    2015                 2020                 2025             


Arg Ser  Ile Val Tyr Leu Glu  Ile Asp Asn Arg Gln  Cys Val Gln 
    2030                 2035                 2040             


Ser Ser  Ser Gln Cys Phe Gln  Ser Ala Thr Asp Val  Ala Ala Phe 
    2045                 2050                 2055             


Leu Gly  Ala Leu Ala Ser Leu  Gly Ser Leu Asn Ile  Pro Tyr Lys 
    2060                 2065                 2070             


Ile Glu  Ala Val Gln Ser Glu  Thr Val Glu Pro Pro  Pro Pro Pro 
    2075                 2080                 2085             


Pro Leu  His Phe Met Tyr Val  Ala Val Val Ala Phe  Val Leu Leu 
    2090                 2095                 2100             


Phe Phe  Val Gly Cys Gly Val  Leu Leu Ser Arg Lys  Arg Arg Arg 
    2105                 2110                 2115             


Gln His  Gly Gln Leu Trp Phe  Pro Glu Gly Phe Lys  Val Ser Glu 
    2120                 2125                 2130             


Ala Ser  Lys Lys Lys Arg Arg  Glu Pro Leu Gly Glu  Asp Ser Val 
    2135                 2140                 2145             


Gly Leu  Lys Pro Leu Lys Asn  Ser Ser Asp Gly Ala  Leu Met Asp 
    2150                 2155                 2160             


Asp Asn  Gln Asn Glu Trp Gly  Asp Glu Gly Leu Glu  Ala Lys Lys 
    2165                 2170                 2175             


Phe Arg  Phe Glu Glu Pro Val  Val Leu Pro Asp Leu  Asp Asp Gln 
    2180                 2185                 2190             


Thr Asp  His Arg Gln Trp Thr  Gln Gln His Leu Asp  Ala Ala Asp 
    2195                 2200                 2205             


Leu Arg  Val Ser Ala Met Ala  Pro Thr Pro Pro Gln  Gly Glu Ala 
    2210                 2215                 2220             


Asp Ala  Asp Cys Met Asp Val  Asn Val Arg Gly Pro  Asp Gly Phe 
    2225                 2230                 2235             


Thr Pro  Leu Met Ile Ala Ser  Cys Ser Gly Gly Gly  Leu Glu Thr 
    2240                 2245                 2250             


Gly Asn  Ser Glu Glu Glu Glu  Asp Ala Pro Ala Val  Ile Ser Asp 
    2255                 2260                 2265             


Phe Ile  Tyr Gln Gly Ala Ser  Leu His Asn Gln Thr  Asp Arg Thr 
    2270                 2275                 2280             


Gly Glu  Thr Ala Leu His Leu  Ala Ala Arg Tyr Ser  Arg Ser Asp 
    2285                 2290                 2295             


Ala Ala  Lys Arg Leu Leu Glu  Ala Ser Ala Asp Ala  Asn Ile Gln 
    2300                 2305                 2310             


Asp Asn  Met Gly Arg Thr Pro  Leu His Ala Ala Val  Ser Ala Asp 
    2315                 2320                 2325             


Ala Gln  Gly Val Phe Gln Ile  Leu Ile Arg Asn Arg  Ala Thr Asp 
    2330                 2335                 2340             


Leu Asp  Ala Arg Met His Asp  Gly Thr Thr Pro Leu  Ile Leu Ala 
    2345                 2350                 2355             


Ala Arg  Leu Ala Val Glu Gly  Met Leu Glu Asp Leu  Ile Asn Ser 
    2360                 2365                 2370             


His Ala  Asp Val Asn Ala Val  Asp Asp Leu Gly Lys  Ser Ala Leu 
    2375                 2380                 2385             


His Trp  Ala Ala Ala Val Asn  Asn Val Glu Ala Ala  Val Val Leu 
    2390                 2395                 2400             


Leu Lys  Asn Gly Ala Asn Lys  Asp Met Gln Asn Asn  Lys Glu Glu 
    2405                 2410                 2415             


Thr Pro  Leu Phe Leu Ala Ala  Arg Glu Gly Ser Tyr  Glu Thr Ala 
    2420                 2425                 2430             


Lys Val  Leu Leu Asp His Phe  Ala Asn Arg Asp Ile  Thr Asp His 
    2435                 2440                 2445             


Met Asp  Arg Leu Pro Arg Asp  Ile Ala Gln Glu Arg  Met His His 
    2450                 2455                 2460             


Asp Ile  Val Arg Leu Leu Asp  Glu Tyr Ser Leu Val  Arg Ser Pro 
    2465                 2470                 2475             


Pro Leu  His Gly Ala Thr Leu  Gly Gly Thr Pro Thr  Leu Ser Pro 
    2480                 2485                 2490             


Pro Leu  Cys Ser Pro Asn Gly  Tyr Leu Gly Asn Leu  Lys Pro Pro 
    2495                 2500                 2505             


Met Gln  Gly Lys Lys Ala Arg  Lys Pro Ser Thr Lys  Gly Leu Ala 
    2510                 2515                 2520             


Cys Gly  Gly Lys Glu Pro Lys  Asp Leu Lys Ala Arg  Arg Lys Lys 
    2525                 2530                 2535             


Ser Gln  Asp Gly Lys Gly Cys  Leu Leu Asp Ser Gly  Ser Val Met 
    2540                 2545                 2550             


Ser Pro  Val Asp Ser Leu Glu  Ser Pro His Gly Tyr  Leu Ser Asp 
    2555                 2560                 2565             


Val Ala  Ser Pro Pro Leu Leu  Pro Ser Pro Phe Gln  Pro Ser Pro 
    2570                 2575                 2580             


Ser Val  Pro Leu Asn His Leu  Pro Gly Met Pro Glu  Thr His Leu 
    2585                 2590                 2595             


Gly Val  Ser His Leu Ser Val  Ala Ala Lys Pro Glu  Met Ala Val 
    2600                 2605                 2610             


Leu Ser  Gly Gly Ser Arg Leu  Ala Phe Glu Ala Gly  Pro Pro Arg 
    2615                 2620                 2625             


Leu Ser  His Leu Pro Val Ala  Ser Ser Thr Ser Thr  Ile Leu Gly 
    2630                 2635                 2640             


Ser Gly  Gly Ser Gly Gly Ser  Gly Ala Val Asn Phe  Thr Val Gly 
    2645                 2650                 2655             


Gly Ala  Ala Gly Leu Asn Gly  Gln Cys Glu Trp Leu  Ser Arg Leu 
    2660                 2665                 2670             


Gln Asn  Gly Leu Val Pro Asn  Gln Tyr Asn Pro Leu  Arg Gly Gly 
    2675                 2680                 2685             


Val Thr  Pro Gly Thr Leu Ser  Thr Gln Ala Ala Gly  Leu Gln His 
    2690                 2695                 2700             


Gly Thr  Val Gly Pro Leu His  Ala Pro Ala Leu Ser  Gln Val Met 
    2705                 2710                 2715             


Thr Tyr  Gln Ala Leu Pro Ser  Thr Arg Leu Ala Ser  Gln Pro His 
    2720                 2725                 2730             


Leu Val  Gln Pro Gln Gln Asn  Leu Gln Met Gln Pro  Pro Ser Met 
    2735                 2740                 2745             


Pro Pro  Gln Pro Asn Leu Gln  Pro His Leu Gly Val  Ser Ser Ala 
    2750                 2755                 2760             


Ala Ser  Gly His Leu Gly Arg  Ser Phe Leu Gly Gly  Glu Leu Ser 
    2765                 2770                 2775             


Gln Ala  Asp Met Gln Pro Leu  Gly Pro Gly Asn Leu  Ala Ala His 
    2780                 2785                 2790             


Thr Val  Leu Pro Gln Asp Gly  Gln Val Leu Pro Thr  Ser Leu Pro 
    2795                 2800                 2805             


Ser Thr  Leu Ala Pro Pro Thr  Met Ala Pro Pro Met  Thr Thr Ala 
    2810                 2815                 2820             


Gln Phe  Leu Thr Pro Pro Ser  Gln His Ser Tyr Ser  Ser Ser Pro 
    2825                 2830                 2835             


Val Asp  Asn Thr Pro Ser His  Gln Leu Gln Val Pro  Glu His Pro 
    2840                 2845                 2850             


Phe Leu  Thr Pro Ser Pro Glu  Ser Pro Asp Gln Trp  Ser Ser Ser 
    2855                 2860                 2865             


Ser Pro  His Ser Asn Ile Ser  Asp Trp Ser Glu Gly  Ile Ser Ser 
    2870                 2875                 2880             


Pro Pro  Thr Ser Val Pro Ser  Gln Ile Ala His Val  Pro Glu Ala 
    2885                 2890                 2895             


Phe Lys  
    2900 


<210>  136
<211>  2561
<212>  PRT
<213>  Gallus gallus

<400>  136

Met Gly Arg Cys Ser Ala Ala His Pro Arg Gly Gly Val His Cys Pro 
1               5                   10                  15      


Gly Leu Cys Ala Val Pro Asp Ala Leu Leu Leu Phe Pro Gly Val Arg 
            20                  25                  30          


Cys Thr Gln Leu Ala Glu Ser Cys Leu Asn Gly Gly Lys Cys Glu Thr 
        35                  40                  45              


Phe Leu Asn Gly Thr Glu Val Cys Gln Cys Ser Ser Ala His Met Gly 
    50                  55                  60                  


Glu Arg Cys Gln Leu Pro Asn Pro Cys Leu Ser Ser Pro Cys Lys Asn 
65                  70                  75                  80  


Ala Gly Thr Cys Ile Pro Leu Leu Arg Gly Ser Thr Ala Asp Tyr Thr 
                85                  90                  95      


Cys Val Cys Arg Leu Gly Phe Thr Asp Glu Leu Cys Leu Thr Pro Leu 
            100                 105                 110         


Asp Asn Ala Cys Leu Asn Asn Pro Cys Arg Asn Gly Gly Thr Cys Asp 
        115                 120                 125             


Leu Val Thr Leu Ser Glu Tyr Lys Cys Arg Cys Pro Pro Gly Trp Ser 
    130                 135                 140                 


Gly Lys Thr Cys Gln Gln Ala Asp Pro Cys Ala Ser Asn Pro Cys Ala 
145                 150                 155                 160 


Asn Gly Gly Gln Cys Val Pro Phe Glu Ala His Tyr Ile Cys Arg Cys 
                165                 170                 175     


Thr Ala Gly Phe His Gly Ala Asn Cys Lys Gln Asp Val Asn Glu Cys 
            180                 185                 190         


Asn Ile Ser Pro Pro Val Cys Lys Asn Gly Gly Ser Cys Thr Asn Glu 
        195                 200                 205             


Val Gly Thr Tyr Gln Cys Ser Cys Lys Pro Ala Tyr Thr Gly Gln Asn 
    210                 215                 220                 


Cys Glu His Leu Tyr Val Pro Cys Asn Pro Ser Pro Cys Gln Asn Gly 
225                 230                 235                 240 


Gly Thr Cys Arg Gln Thr Gly Asp Thr Thr Tyr Asp Cys Thr Cys Leu 
                245                 250                 255     


Pro Gly Phe Thr Gly Gln Asn Cys Glu Glu Asn Ile Asp Asp Cys Pro 
            260                 265                 270         


Gly Asn Asn Cys Arg Asn Gly Gly Thr Cys Val Asp Gly Val Asn Thr 
        275                 280                 285             


Tyr Asn Cys Gln Cys Pro Pro Glu Trp Thr Gly Gln Tyr Cys Thr Glu 
    290                 295                 300                 


Asp Val Asp Glu Cys Gln Leu Met Pro Asn Ala Cys Gln Asn Gly Gly 
305                 310                 315                 320 


Thr Cys His Asn Asn His Gly Gly Tyr Asn Cys Val Cys Val Asn Gly 
                325                 330                 335     


Trp Thr Gly Glu Asp Cys Ser Glu Asn Ile Asp Asp Cys Ala Met Ala 
            340                 345                 350         


Ala Cys Phe Gln Gly Ala Thr Cys His Asp Arg Val Ala Ser Phe Tyr 
        355                 360                 365             


Cys Glu Cys Pro His Gly Arg Thr Gly Leu Leu Cys His Leu Asp Asp 
    370                 375                 380                 


Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly Ser Asn Cys Asp Thr Asn 
385                 390                 395                 400 


Pro Val Asn Gly Lys Ala Ile Cys Thr Cys Pro Ser Gly Tyr Met Gly 
                405                 410                 415     


Pro Ala Cys Asn Gln Asp Val Asp Glu Cys Ser Leu Gly Ala Asn Pro 
            420                 425                 430         


Cys Glu His Ala Gly Lys Cys Ile Asn Thr Gln Gly Ser Phe Gln Cys 
        435                 440                 445             


Gln Cys Leu Gln Gly Tyr Ser Gly Pro Arg Cys Glu Ile Asp Val Asn 
    450                 455                 460                 


Glu Cys Leu Ser Asn Pro Cys Gln Asn Asp Ala Thr Cys Leu Asp Gln 
465                 470                 475                 480 


Ile Gly Glu Phe Gln Cys Ile Cys Met Pro Gly Tyr Glu Gly Val Tyr 
                485                 490                 495     


Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser Ser Pro Cys Leu His Asn 
            500                 505                 510         


Gly Asn Cys Leu Asp Lys Ile Asn Glu Phe His Cys Glu Cys Pro Thr 
        515                 520                 525             


Gly Phe Asn Gly His Leu Cys Gln Phe Asp Ile Asp Glu Cys Ala Ser 
    530                 535                 540                 


Thr Pro Cys Lys Asn Gly Ala Lys Cys Val Asp Gly Pro Asn Thr Tyr 
545                 550                 555                 560 


Ser Cys Glu Cys Thr Glu Gly Phe Ser Gly Val His Cys Glu Ile Asp 
                565                 570                 575     


Ile Asp Glu Cys Asn Pro Asp Pro Cys His Tyr Gly Thr Cys Lys Asp 
            580                 585                 590         


Ser Ile Ala Ala Phe Thr Cys Leu Cys Gln Pro Gly Tyr Thr Gly His 
        595                 600                 605             


Arg Cys Asp Ile Asn Ile Asn Glu Cys Gln Ser Gln Pro Cys Arg Asn 
    610                 615                 620                 


Gly Gly Thr Cys Gln Asp Arg Asp Asn Ala Tyr Asn Cys Leu Cys Leu 
625                 630                 635                 640 


Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile Asn Leu Asp Asp Cys Ala 
                645                 650                 655     


Ser Asn Pro Cys Asp Tyr Gly Lys Cys Ile Asp Lys Ile Asn Gly Tyr 
            660                 665                 670         


Glu Cys Thr Cys Glu Pro Gly Tyr Thr Gly Arg Met Cys Asn Ile Asn 
        675                 680                 685             


Ile Asp Glu Cys Ala Ser Asn Pro Cys His Asn Gly Gly Thr Cys Lys 
    690                 695                 700                 


Asp Gly Ile Asn Gly Phe Thr Cys Leu Cys Pro Glu Gly Phe His Asp 
705                 710                 715                 720 


Pro Lys Cys Leu Ser Glu Val Asn Glu Cys Asn Ser Asn Pro Cys Ile 
                725                 730                 735     


His Gly Arg Cys His Asp Gly Leu Asn Gly Tyr Arg Cys Asp Cys Asp 
            740                 745                 750         


Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile Asn Asn Asn Glu Cys Glu 
        755                 760                 765             


Ser Asn Pro Cys Met Asn Gly Gly Thr Cys Lys Asp Met Thr Ser Gly 
    770                 775                 780                 


Tyr Ile Cys Thr Cys Arg Glu Gly Phe Ser Gly Pro Asn Cys Gln Thr 
785                 790                 795                 800 


Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys 
                805                 810                 815     


Ile Asp Asp Val Ala Gly Tyr Thr Cys Asn Cys Leu Leu Pro Tyr Thr 
            820                 825                 830         


Gly Ala Thr Cys Glu Asp Val Leu Ala Pro Cys Ala Gly Gly Pro Cys 
        835                 840                 845             


Lys Asn Gly Gly Glu Cys Arg Glu Ser Glu Asp Tyr Lys Arg Phe Ser 
    850                 855                 860                 


Cys Ser Cys Pro Pro Gly Trp Gln Gly Gln Thr Cys Glu Ile Asp Ile 
865                 870                 875                 880 


Asn Glu Cys Val Lys Ser Pro Cys Arg Asn Gly Ala Thr Cys Gln Asn 
                885                 890                 895     


Thr Asn Gly Ser Tyr Arg Cys Leu Cys Arg Val Gly Phe Ala Gly Arg 
            900                 905                 910         


Asn Cys Asp Thr Asp Ile Asp Asp Cys Gln Pro Asn Pro Cys His Asn 
        915                 920                 925             


Gly Gly Ser Cys Ser Asp Gly Ile Gly Thr Phe Phe Cys Glu Cys Leu 
    930                 935                 940                 


Ala Gly Phe Arg Gly Leu Lys Cys Glu Glu Asp Ile Asn Glu Cys Ala 
945                 950                 955                 960 


Ser Asn Pro Cys Lys Asn Gly Ala Asn Cys Thr Asp Cys Val Asn Ser 
                965                 970                 975     


Tyr Thr Cys Thr Cys Pro Ser Gly Phe Ser Gly Ile His Cys Glu Asn 
            980                 985                 990         


Asn Thr Pro Asp Cys Thr Glu Ser  Ser Cys Phe Asn Gly  Gly Thr Cys 
        995                 1000                 1005             


Val Asp  Gly Ile Asn Thr Phe  Thr Cys Leu Cys Pro  Ser Gly Phe 
    1010                 1015                 1020             


Thr Gly  Ser Tyr Cys Glu His  Asn Ile Asn Glu Cys  Asp Ser Lys 
    1025                 1030                 1035             


Pro Cys  Leu Asn Gly Gly Thr  Cys Gln Asp Ser Tyr  Gly Thr Tyr 
    1040                 1045                 1050             


Lys Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly Leu Asn  Cys Gln Asn 
    1055                 1060                 1065             


Leu Val  Arg Trp Cys Asp Ser  Ser Pro Cys Lys Asn  Gly Gly Lys 
    1070                 1075                 1080             


Cys Trp  Gln Thr Asn Asn Leu  Tyr Arg Cys Glu Cys  Asn Ser Gly 
    1085                 1090                 1095             


Trp Thr  Gly Leu Tyr Cys Asp  Val Pro Ser Val Ser  Cys Glu Val 
    1100                 1105                 1110             


Ala Ala  Lys Gln Gln Gly Ile  Asp Val Ala His Leu  Cys Arg Asn 
    1115                 1120                 1125             


Ser Gly  Leu Cys Val Asp Ser  Gly Asn Thr His Phe  Cys Arg Cys 
    1130                 1135                 1140             


Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu Glu Gln  Val Asp Glu 
    1145                 1150                 1155             


Cys Ser  Pro Asn Pro Cys Gln  Asn Gly Ala Thr Cys  Thr Asp Tyr 
    1160                 1165                 1170             


Leu Gly  Gly Tyr Ser Cys Glu  Cys Val Ala Gly Tyr  His Gly Val 
    1175                 1180                 1185             


Asn Cys  Ser Glu Glu Ile Asn  Glu Cys Leu Ser His  Pro Cys Gln 
    1190                 1195                 1200             


Asn Gly  Gly Thr Cys Ile Asp  Leu Ile Asn Thr Tyr  Lys Cys Ser 
    1205                 1210                 1215             


Cys Pro  Arg Gly Thr Gln Gly  Val His Cys Glu Ile  Asn Val Asp 
    1220                 1225                 1230             


Asp Cys  Ser Pro Phe Phe Asp  Pro Val Thr Leu Gly  Pro Lys Cys 
    1235                 1240                 1245             


Phe Asn  Asn Gly Lys Cys Thr  Asp Arg Val Gly Gly  Tyr Ser Cys 
    1250                 1255                 1260             


Ile Cys  Pro Pro Gly Phe Val  Gly Glu Arg Cys Glu  Gly Asp Val 
    1265                 1270                 1275             


Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Ala Arg Gly  Thr Gln Asn 
    1280                 1285                 1290             


Cys Val  Gln Arg Val Asn Asp  Tyr Lys Cys Glu Cys  Arg Pro Gly 
    1295                 1300                 1305             


Tyr Ala  Gly Arg Arg Cys Asp  Thr Val Val Asp Gly  Cys Lys Gly 
    1310                 1315                 1320             


Lys Pro  Cys Arg Asn Gly Gly  Thr Cys Ala Val Ala  Ser Asn Thr 
    1325                 1330                 1335             


Gly Arg  Gly Phe Ile Cys Lys  Cys Pro Pro Gly Phe  Val Gly Ala 
    1340                 1345                 1350             


Thr Cys  Glu Asn Asp Ser His  Thr Cys Gly Thr Leu  His Cys Leu 
    1355                 1360                 1365             


Asn Gly  Gly Thr Cys Ile Ser  Met His Lys Ser Ser  Lys Cys Val 
    1370                 1375                 1380             


Cys Ala  Ala Ala Phe Thr Gly  Pro Glu Cys Gln Tyr  Pro Ala Ser 
    1385                 1390                 1395             


Ser Pro  Cys Ile Ser Asn Pro  Cys Tyr Asn Gly Gly  Thr Cys Glu 
    1400                 1405                 1410             


Phe Leu  Ser Asp Ala Ser Pro  Tyr Tyr His Cys Asn  Cys Pro Ala 
    1415                 1420                 1425             


Asn Phe  Asn Gly Leu Asn Cys  His Ile Leu Asp Phe  Asp Phe Gln 
    1430                 1435                 1440             


Gly Gly  Phe Gly Gln Asp Ile  Ile Pro Pro Lys Ile  Glu Glu Lys 
    1445                 1450                 1455             


Cys Glu  Ile Ala Val Cys Ala  Ser Tyr Ala Gly Asn  Lys Ile Cys 
    1460                 1465                 1470             


Asp Gly  Lys Cys Asn Asn His  Ala Cys Gly Trp Asp  Gly Gly Asp 
    1475                 1480                 1485             


Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys Asn Cys  Ser Gln Ser 
    1490                 1495                 1500             


Leu Gln  Cys Trp Lys Tyr Phe  Asn Asp Gly Lys Cys  Asp Ser Gln 
    1505                 1510                 1515             


Cys Asn  Asn Ala Gly Cys Leu  Tyr Asp Gly Phe Asp  Cys Gln Lys 
    1520                 1525                 1530             


Tyr Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp Gln Tyr  Cys Lys Asp 
    1535                 1540                 1545             


His Phe  Ser Asp Gly His Cys  Asp Gln Gly Cys Asn  Asn Phe Glu 
    1550                 1555                 1560             


Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Asn Asn Met  Pro Glu Lys 
    1565                 1570                 1575             


Leu Ala  Asp Gly Thr Leu Val  Val Val Val Leu Ile  Thr Pro Glu 
    1580                 1585                 1590             


Asn Leu  Lys Asn Asn Ser Phe  Asn Phe Leu Arg Glu  Leu Ser Arg 
    1595                 1600                 1605             


Val Leu  His Thr Asn Val Val  Phe Lys Lys Asn Ala  Lys Gly Glu 
    1610                 1615                 1620             


Tyr Met  Ile Phe Pro Tyr Tyr  Gly Asn Glu Glu Glu  Leu Lys Lys 
    1625                 1630                 1635             


His Tyr  Ile Lys Arg Ser Thr  Glu Asp Trp Ala Asp  Met Ser Ser 
    1640                 1645                 1650             


Ala Val  Ile Asn Lys Val Lys  Ser Ser Leu Tyr Ser  Arg Ala Gly 
    1655                 1660                 1665             


Arg Arg  Gln Lys Arg Glu Leu  Asp Gln Met Asp Ile  Arg Gly Ser 
    1670                 1675                 1680             


Ile Val  Tyr Leu Glu Ile Asp  Asn Arg Gln Cys Ile  Gln Ser Ser 
    1685                 1690                 1695             


Ser Gln  Cys Phe Gln Ser Ala  Thr Asp Val Ala Ala  Phe Leu Gly 
    1700                 1705                 1710             


Ala Leu  Ala Ser Leu Gly Asn  Leu Asn Ile Pro Tyr  Lys Ile Glu 
    1715                 1720                 1725             


Ala Val  Lys Ser Glu Thr Ala  Glu Pro Ala Arg Asn  Ser Gln Leu 
    1730                 1735                 1740             


Tyr Pro  Met Tyr Val Val Val  Ala Ala Leu Val Leu  Leu Ala Phe 
    1745                 1750                 1755             


Ile Gly  Val Gly Val Leu Val  Ser Arg Lys Arg Arg  Arg Glu His 
    1760                 1765                 1770             


Gly Gln  Leu Trp Phe Pro Glu  Gly Phe Lys Val Thr  Glu Ser Ser 
    1775                 1780                 1785             


Lys Lys  Lys Arg Arg Glu Pro  Leu Gly Glu Asp Ser  Val Gly Leu 
    1790                 1795                 1800             


Lys Pro  Leu Lys Asn Ala Ser  Asp Gly Thr Leu Met  Asp Asp Asn 
    1805                 1810                 1815             


Gln Asn  Glu Trp Gly Asp Glu  Glu Thr Leu Asp Thr  Lys Lys Phe 
    1820                 1825                 1830             


Arg Phe  Glu Glu Gln Ala Met  Leu Pro Asp Thr Asp  Asp Gln Thr 
    1835                 1840                 1845             


Asp His  Arg Gln Trp Thr Gln  Gln His Leu Asp Ala  Ala Asp Leu 
    1850                 1855                 1860             


Arg Ile  Ser Ser Met Ala Pro  Thr Pro Pro Gln Gly  Glu Ile Asp 
    1865                 1870                 1875             


Ala Asp  Cys Met Asp Val Asn  Val Arg Gly Pro Asp  Gly Phe Thr 
    1880                 1885                 1890             


Pro Leu  Met Ile Ala Ser Cys  Ser Gly Gly Gly Leu  Glu Thr Gly 
    1895                 1900                 1905             


Asn Ser  Glu Glu Glu Asp Asp  Ala Pro Ala Val Ile  Ser Asp Phe 
    1910                 1915                 1920             


Ile Tyr  Gln Gly Ala Ser Leu  His Asn Gln Thr Asp  Arg Thr Gly 
    1925                 1930                 1935             


Glu Thr  Ala Leu His Leu Ala  Ala Arg Tyr Ser Arg  Ser Asp Ala 
    1940                 1945                 1950             


Ala Lys  Arg Leu Leu Glu Ala  Ser Ala Asp Ala Asn  Ile Gln Asp 
    1955                 1960                 1965             


Asn Met  Gly Arg Thr Pro Leu  His Ala Ala Val Ser  Ala Asp Ala 
    1970                 1975                 1980             


Gln Gly  Val Phe Gln Ile Leu  Ile Arg Asn Arg Ala  Thr Asp Leu 
    1985                 1990                 1995             


Asp Ala  Arg Met His Asp Gly  Thr Thr Pro Leu Ile  Leu Ala Ala 
    2000                 2005                 2010             


Arg Leu  Ala Val Glu Gly Met  Leu Glu Asp Leu Ile  Asn Cys His 
    2015                 2020                 2025             


Ala Asp  Val Asn Ala Val Asp  Asp Leu Gly Lys Ser  Ala Leu His 
    2030                 2035                 2040             


Trp Ala  Ala Ala Val Asn Asn  Val Glu Ala Ala Val  Val Leu Leu 
    2045                 2050                 2055             


Lys Asn  Gly Ala Asn Lys Asp  Met Gln Asn Asn Lys  Glu Glu Thr 
    2060                 2065                 2070             


Pro Leu  Phe Leu Ala Ala Arg  Glu Gly Ser Tyr Glu  Thr Ala Lys 
    2075                 2080                 2085             


Val Leu  Leu Asp His Phe Ala  Asn Arg Asp Ile Thr  Asp His Met 
    2090                 2095                 2100             


Asp Arg  Leu Pro Arg Asp Ile  Ala Gln Glu Arg Met  His His Asp 
    2105                 2110                 2115             


Ile Val  Arg Leu Leu Asp Glu  Tyr Asn Leu Val Arg  Ser Pro Pro 
    2120                 2125                 2130             


Leu His  Ser Gly Pro Leu Gly  Ala Pro Thr Leu Ser  Pro Pro Leu 
    2135                 2140                 2145             


Cys Ser  Pro Ser Ser Tyr Ile  Gly Asn Leu Lys Pro  Ala Val Gln 
    2150                 2155                 2160             


Gly Lys  Lys Ala Arg Lys Pro  Ser Thr Lys Gly Leu  Ser Cys Asn 
    2165                 2170                 2175             


Gly Lys  Asp Ser Lys Asp Leu  Lys Ala Arg Arg Lys  Lys Ser Gln 
    2180                 2185                 2190             


Asp Gly  Lys Gly Cys Leu Leu  Asp Asn Ser Ser Val  Leu Ser Pro 
    2195                 2200                 2205             


Val Asp  Ser Leu Glu Ser Pro  His Gly Tyr Leu Ser  Asp Val Ala 
    2210                 2215                 2220             


Ser Pro  Pro Leu Met Thr Ser  Pro Phe Gln Gln Ser  Pro Ser Met 
    2225                 2230                 2235             


Pro Leu  Asn His Leu Pro Gly  Met Pro Asp Ala His  Met Ser Ile 
    2240                 2245                 2250             


Asn His  Leu Asn Met Ala Gly  Lys Gln Glu Met Ala  Leu Gly Gly 
    2255                 2260                 2265             


Ser Gly  Arg Met Ala Phe Glu  Ala Val Pro Pro Arg  Leu Ser His 
    2270                 2275                 2280             


Leu Pro  Val Ser Ser Pro Ser  Thr Ala Met Ser Asn  Ala Pro Met 
    2285                 2290                 2295             


Asn Phe  Ser Val Gly Gly Ala  Ala Gly Leu Ser Gly  Gln Cys Asp 
    2300                 2305                 2310             


Trp Leu  Ser Arg Leu Gln Ser  Gly Met Val Gln Asn  Gln Tyr Gly 
    2315                 2320                 2325             


Ala Met  Arg Gly Gly Met Gln  Pro Gly Thr His Gln  Gln Ala Gln 
    2330                 2335                 2340             


Asn Leu  Gln His Gly Met Met  Ser Ser Leu His Asn  Gly Leu Pro 
    2345                 2350                 2355             


Ser Thr  Ser Leu Ser Gln Met  Met Ser Tyr Gln Ala  Met Pro Ser 
    2360                 2365                 2370             


Thr Arg  Leu Ala Ser Gln Pro  His Leu Leu Gln Asn  Gln Gln Met 
    2375                 2380                 2385             


Gln Gln  Met Gln Gln Pro Gly  Met Gln Pro Gln Pro  Gly Met Gln 
    2390                 2395                 2400             


Pro Gln  Pro Gly Met Gln Gln  Pro Gln Gln Gln Pro  Gln Gln Gln 
    2405                 2410                 2415             


Pro Gln  Pro Gln Gln His His  Asn Pro Gly Ser Asn  Ala Ser Gly 
    2420                 2425                 2430             


His Met  Gly Gln Asn Phe Leu  Gly Thr Glu Leu Ser  Gln Pro Asp 
    2435                 2440                 2445             


Met Gln  Pro Val Ser Ser Ser  Ala Met Ala Val His  Thr Ile Leu 
    2450                 2455                 2460             


Pro Gln  Asp Ser Gln Leu Leu  Pro Thr Ser Leu Pro  Ser Ser Leu 
    2465                 2470                 2475             


Ala Gln  Pro Met Thr Thr Thr  Gln Phe Leu Thr Pro  Pro Ser Gln 
    2480                 2485                 2490             


His Ser  Tyr Ser Ser Pro Leu  Asp Asn Thr Pro Ser  His Gln Leu 
    2495                 2500                 2505             


Gln Val  Pro Asp His Pro Phe  Leu Thr Pro Ser Pro  Glu Ser Pro 
    2510                 2515                 2520             


Asp Gln  Trp Ser Ser Ser Ser  Pro His Ser Asn Val  Ser Asp Trp 
    2525                 2530                 2535             


Ser Glu  Gly Ile Ser Ser Pro  Pro Thr Ser Met Gln  Ser Gln Met 
    2540                 2545                 2550             


Gly His  Ile Pro Glu Ala Phe  Lys 
    2555                 2560     


<210>  137
<211>  2531
<212>  PRT
<213>  Rattus norvegicus

<400>  137

Met Pro Arg Leu Leu Ala Pro Leu Leu Cys Leu Thr Leu Leu Pro Ala 
1               5                   10                  15      


Leu Ala Ala Arg Gly Leu Arg Cys Ser Gln Pro Ser Gly Thr Cys Leu 
            20                  25                  30          


Asn Gly Gly Arg Cys Glu Val Ala Asn Gly Thr Glu Ala Cys Val Cys 
        35                  40                  45              


Ser Gly Ala Phe Val Gly Gln Arg Cys Gln Asp Pro Ser Pro Cys Leu 
    50                  55                  60                  


Ser Thr Pro Cys Lys Asn Ala Gly Thr Cys Tyr Val Val Asp His Gly 
65                  70                  75                  80  


Gly Ile Val Asp Tyr Ala Cys Ser Cys Pro Leu Gly Phe Ser Gly Pro 
                85                  90                  95      


Leu Cys Leu Thr Pro Leu Ala Asn Ala Cys Leu Ala Asn Pro Cys Arg 
            100                 105                 110         


Asn Gly Gly Thr Cys Asp Leu Leu Thr Leu Thr Glu Tyr Lys Cys Arg 
        115                 120                 125             


Cys Pro Pro Gly Trp Ser Gly Lys Ser Cys Gln Gln Ala Asp Pro Cys 
    130                 135                 140                 


Ala Ser Asn Pro Cys Ala Asn Gly Gly Gln Cys Leu Pro Phe Glu Ser 
145                 150                 155                 160 


Ser Tyr Ile Cys Gly Cys Pro Pro Gly Phe His Gly Pro Thr Cys Arg 
                165                 170                 175     


Gln Asp Val Asn Glu Cys Ser Gln Asn Pro Gly Leu Cys Arg His Gly 
            180                 185                 190         


Gly Thr Cys His Asn Glu Ile Gly Ser Tyr Arg Cys Ala Cys Arg Ala 
        195                 200                 205             


Thr His Thr Gly Pro His Cys Glu Leu Pro Tyr Val Pro Cys Ser Pro 
    210                 215                 220                 


Ser Pro Cys Gln Asn Gly Gly Thr Cys Arg Pro Thr Gly Asp Thr Thr 
225                 230                 235                 240 


His Glu Cys Ala Cys Leu Pro Gly Phe Ala Gly Gln Asn Cys Glu Glu 
                245                 250                 255     


Asn Val Asp Asp Cys Pro Gly Asn Asn Cys Lys Asn Gly Gly Ala Cys 
            260                 265                 270         


Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro Glu Trp Thr 
        275                 280                 285             


Gly Gln Tyr Cys Thr Glu Asp Val Asp Glu Cys Gln Leu Met Pro Asn 
    290                 295                 300                 


Ala Cys Gln Asn Ala Gly Thr Cys His Asn Ser His Gly Gly Tyr Asn 
305                 310                 315                 320 


Cys Val Cys Val Asn Gly Trp Thr Gly Glu Asp Cys Ser Asp Asn Ile 
                325                 330                 335     


Asp Asp Cys Ala Ser Ala Ala Cys Phe Gln Gly Ala Thr Cys His Asp 
            340                 345                 350         


Arg Val Ala Ser Phe Tyr Cys Glu Cys Pro His Gly Arg Thr Gly Leu 
        355                 360                 365             


Leu Cys His Leu Asn Asp Ala Cys Ile Ser Asn Pro Cys Asn Glu Gly 
    370                 375                 380                 


Ser Asn Cys Asp Thr Asn Pro Val Asn Gly Lys Ala Ile Cys Thr Cys 
385                 390                 395                 400 


Pro Arg Gly Tyr Thr Gly Pro Ala Cys Ser Gln Asp Val Asp Glu Cys 
                405                 410                 415     


Ala Leu Gly Ala Asn Pro Cys Glu His Ala Gly Lys Cys Leu Asn Thr 
            420                 425                 430         


Leu Gly Ser Phe Glu Cys Gln Cys Leu Gln Gly Tyr Thr Gly Pro Arg 
        435                 440                 445             


Cys Glu Ile Asp Val Asn Glu Cys Ile Ser Asn Pro Cys Gln Asn Asp 
    450                 455                 460                 


Ala Thr Cys Leu Asp Gln Ile Gly Glu Phe Gln Cys Ile Cys Met Pro 
465                 470                 475                 480 


Gly Tyr Glu Gly Val Tyr Cys Glu Ile Asn Thr Asp Glu Cys Ala Ser 
                485                 490                 495     


Ser Pro Cys Leu His Asn Gly Arg Cys Val Asp Lys Ile Asn Glu Phe 
            500                 505                 510         


Leu Cys Gln Cys Pro Lys Gly Phe Ser Gly His Leu Cys Gln Tyr Asp 
        515                 520                 525             


Val Asp Glu Cys Ala Ser Thr Pro Cys Lys Asn Gly Ala Lys Cys Leu 
    530                 535                 540                 


Asp Gly Pro Asn Thr Tyr Thr Cys Val Cys Thr Glu Gly Tyr Thr Gly 
545                 550                 555                 560 


Thr His Cys Glu Val Asp Ile Asp Glu Cys Asp Pro Asp Pro Cys His 
                565                 570                 575     


Ile Gly Leu Cys Lys Asp Gly Val Ala Thr Phe Thr Cys Leu Cys Gln 
            580                 585                 590         


Pro Gly Tyr Thr Gly His His Cys Glu Thr Asn Ile Asn Glu Cys His 
        595                 600                 605             


Ser Gln Pro Cys Arg His Gly Gly Thr Cys Gln Asp Arg Asp Asn Tyr 
    610                 615                 620                 


Tyr Leu Cys Leu Cys Leu Lys Gly Thr Thr Gly Pro Asn Cys Glu Ile 
625                 630                 635                 640 


Asn Leu Asp Asp Cys Ala Ser Asn Pro Cys Asp Ser Gly Thr Cys Leu 
                645                 650                 655     


Asp Lys Ile Asp Gly Tyr Glu Cys Ala Cys Glu Pro Gly Tyr Thr Gly 
            660                 665                 670         


Ser Met Cys Asn Val Asn Ile Asp Glu Cys Ala Gly Ser Pro Cys His 
        675                 680                 685             


Asn Gly Gly Thr Cys Glu Asp Gly Ile Ala Gly Phe Thr Cys Arg Cys 
    690                 695                 700                 


Pro Glu Gly Tyr His Asp Pro Thr Cys Leu Ser Glu Val Asn Glu Cys 
705                 710                 715                 720 


Asn Ser Asn Pro Cys Ile His Gly Ala Cys Arg Asp Gly Leu Asn Gly 
                725                 730                 735     


Tyr Lys Cys Asp Cys Ala Pro Gly Trp Ser Gly Thr Asn Cys Asp Ile 
            740                 745                 750         


Asn Asn Asn Glu Cys Glu Ser Asn Pro Cys Val Asn Gly Gly Thr Cys 
        755                 760                 765             


Lys Asp Met Thr Ser Gly Tyr Val Cys Thr Cys Arg Glu Gly Phe Ser 
    770                 775                 780                 


Gly Pro Asn Cys Gln Thr Asn Ile Asn Glu Cys Ala Ser Asn Pro Cys 
785                 790                 795                 800 


Leu Asn Gln Gly Thr Cys Ile Asp Asp Val Ala Gly Tyr Lys Cys Asn 
                805                 810                 815     


Cys Pro Leu Pro Tyr Thr Gly Ala Thr Cys Glu Val Val Leu Ala Pro 
            820                 825                 830         


Cys Ala Thr Ser Pro Cys Lys Asn Ser Gly Val Cys Lys Glu Ser Glu 
        835                 840                 845             


Asp Tyr Glu Ser Phe Ser Cys Val Cys Pro Thr Gly Trp Gln Gly Gln 
    850                 855                 860                 


Thr Cys Glu Ile Asp Ile Asn Glu Cys Val Lys Ser Pro Cys Arg His 
865                 870                 875                 880 


Gly Ala Ser Cys Gln Asn Thr Asn Gly Ser Tyr Arg Cys Leu Cys Gln 
                885                 890                 895     


Ala Gly Tyr Thr Gly Arg Asn Cys Glu Ser Asp Ile Asp Asp Cys Arg 
            900                 905                 910         


Pro Asn Pro Cys His Asn Gly Gly Ser Cys Thr Asp Gly Val Asn Ala 
        915                 920                 925             


Ala Phe Cys Asp Cys Leu Pro Gly Phe Gln Gly Ala Phe Cys Glu Glu 
    930                 935                 940                 


Asp Ile Asn Glu Cys Ala Thr Asn Pro Cys Gln Asn Gly Ala Asn Cys 
945                 950                 955                 960 


Thr Asp Cys Val Asp Ser Tyr Thr Cys Thr Cys Pro Thr Gly Phe Asn 
                965                 970                 975     


Gly Ile His Cys Glu Asn Asn Thr Pro Asp Cys Thr Glu Ser Ser Cys 
            980                 985                 990         


Phe Asn Gly Gly Thr Cys Val Asp  Gly Ile Asn Ser Phe  Thr Cys Leu 
        995                 1000                 1005             


Cys Pro  Pro Gly Phe Thr Gly  Ser Tyr Cys Gln Tyr  Asp Val Asn 
    1010                 1015                 1020             


Glu Cys  Asp Ser Arg Pro Cys  Leu His Gly Gly Thr  Cys Gln Asp 
    1025                 1030                 1035             


Ser Tyr  Gly Thr Tyr Lys Cys  Thr Cys Pro Gln Gly  Tyr Thr Gly 
    1040                 1045                 1050             


Leu Asn  Cys Gln Asn Leu Val  Arg Trp Cys Asp Ser  Ala Pro Cys 
    1055                 1060                 1065             


Lys Asn  Gly Gly Lys Cys Trp  Gln Thr Asn Thr Gln  Tyr His Cys 
    1070                 1075                 1080             


Glu Cys  Arg Ser Gly Trp Thr  Gly Phe Asn Cys Asp  Val Leu Ser 
    1085                 1090                 1095             


Val Ser  Cys Glu Val Ala Ala  Gln Lys Arg Gly Ile  Asp Val Thr 
    1100                 1105                 1110             


Leu Leu  Cys Gln His Gly Gly  Leu Cys Val Asp Glu  Glu Asp Lys 
    1115                 1120                 1125             


His Tyr  Cys His Cys Gln Ala  Gly Tyr Thr Gly Ser  Tyr Cys Glu 
    1130                 1135                 1140             


Asp Glu  Val Asp Glu Cys Ser  Pro Asn Pro Cys Gln  Asn Gly Ala 
    1145                 1150                 1155             


Thr Cys  Thr Asp Tyr Leu Gly  Gly Phe Ser Cys Lys  Cys Val Ala 
    1160                 1165                 1170             


Gly Tyr  His Gly Ser Asn Cys  Ser Glu Glu Ile Asn  Glu Cys Leu 
    1175                 1180                 1185             


Ser Gln  Pro Cys Gln Asn Gly  Gly Thr Cys Ile Asp  Leu Thr Asn 
    1190                 1195                 1200             


Thr Tyr  Lys Cys Ser Cys Pro  Arg Gly Thr Gln Gly  Val His Cys 
    1205                 1210                 1215             


Glu Ile  Asn Val Asp Asp Cys  His Pro Pro Leu Asp  Pro Ala Ser 
    1220                 1225                 1230             


Arg Ser  Pro Lys Cys Phe Asn  Asn Gly Thr Cys Val  Asp Gln Val 
    1235                 1240                 1245             


Gly Gly  Tyr Thr Cys Thr Cys  Pro Pro Gly Phe Val  Gly Glu Arg 
    1250                 1255                 1260             


Cys Glu  Gly Asp Val Asn Glu  Cys Leu Ser Asn Pro  Cys Asp Pro 
    1265                 1270                 1275             


Arg Gly  Thr Gln Asn Cys Val  Gln Arg Val Asn Asp  Phe His Cys 
    1280                 1285                 1290             


Glu Cys  Arg Ala Gly His Thr  Gly Arg Arg Cys Glu  Ser Val Ile 
    1295                 1300                 1305             


Asn Gly  Cys Arg Gly Lys Pro  Cys Arg Asn Gly Gly  Val Cys Ala 
    1310                 1315                 1320             


Val Ala  Ser Asn Thr Ala Arg  Gly Phe Ile Cys Arg  Cys Pro Ala 
    1325                 1330                 1335             


Arg Phe  Glu Gly Ala Thr Cys  Glu Asn Asp Ala Arg  Thr Cys Gly 
    1340                 1345                 1350             


Ser Leu  Arg Cys Leu Asn Gly  Gly Thr Cys Ile Ser  Gly Pro Arg 
    1355                 1360                 1365             


Ser Pro  Thr Cys Leu Cys Leu  Gly Ser Phe Thr Gly  Pro Glu Cys 
    1370                 1375                 1380             


Gln Phe  Pro Ala Ser Ser Pro  Cys Val Gly Ser Asn  Pro Cys Tyr 
    1385                 1390                 1395             


Asn Gln  Gly Thr Cys Glu Pro  Thr Ser Glu Ser Pro  Phe Tyr Arg 
    1400                 1405                 1410             


Cys Leu  Cys Pro Ala Lys Phe  Asn Gly Leu Leu Cys  His Ile Leu 
    1415                 1420                 1425             


Asp Tyr  Ser Phe Thr Gly Ala  Ala Gly Arg Asp Ile  Pro Pro Pro 
    1430                 1435                 1440             


Gln Ile  Glu Glu Ala Cys Glu  Leu Pro Glu Cys Gln  Glu Asp Ala 
    1445                 1450                 1455             


Gly Asn  Lys Val Cys Asn Leu  Gln Cys Asn Asn His  Ala Cys Gly 
    1460                 1465                 1470             


Trp Asp  Gly Gly Asp Cys Ser  Leu Asn Phe Asn Asp  Pro Trp Lys 
    1475                 1480                 1485             


Asn Cys  Thr Gln Ser Leu Gln  Cys Trp Lys Tyr Phe  Ser Asp Gly 
    1490                 1495                 1500             


His Cys  Asp Ser Gln Cys Asn  Ser Ala Gly Cys Leu  Phe Asp Gly 
    1505                 1510                 1515             


Phe Asp  Cys Gln Leu Thr Glu  Gly Gln Cys Asn Pro  Leu Tyr Asp 
    1520                 1525                 1530             


Gln Tyr  Cys Lys Asp His Phe  Ser Asp Gly His Cys  Asp Gln Gly 
    1535                 1540                 1545             


Cys Asn  Ser Ala Glu Cys Glu  Trp Asp Gly Leu Asp  Cys Ala Glu 
    1550                 1555                 1560             


His Val  Pro Glu Arg Leu Ala  Ala Gly Thr Leu Val  Leu Val Val 
    1565                 1570                 1575             


Leu Leu  Pro Pro Asp Gln Leu  Arg Asn Asn Ser Phe  His Phe Leu 
    1580                 1585                 1590             


Arg Asp  Val Ser His Val Leu  His Thr Asn Val Val  Phe Lys Arg 
    1595                 1600                 1605             


Asp Ala  Gln Gly Gln Gln Met  Ile Phe Pro Tyr Tyr  Gly Arg Glu 
    1610                 1615                 1620             


Glu Glu  Leu Arg Lys His Pro  Ile Lys Arg Ser Ala  Val Gly Trp 
    1625                 1630                 1635             


Ala Thr  Thr Ser Leu Leu Pro  Gly Thr Asn Gly Gly  Arg Gln Arg 
    1640                 1645                 1650             


Arg Glu  Leu Asp Pro Met Asp  Ile His Gly Ser Ile  Val Tyr Leu 
    1655                 1660                 1665             


Glu Ile  Asp Asn Arg Gln Cys  Val Gln Ser Ser Ser  Gln Cys Phe 
    1670                 1675                 1680             


Gln Ser  Ala Thr Asp Val Ala  Ala Phe Leu Gly Ala  Leu Ala Ser 
    1685                 1690                 1695             


Leu Gly  Ser Leu Asn Ile Pro  Tyr Lys Ile Glu Ala  Val Lys Ser 
    1700                 1705                 1710             


Glu Thr  Val Glu Pro Pro Leu  Pro Ser Gln Leu His  Leu Met Tyr 
    1715                 1720                 1725             


Val Ala  Ala Ala Ala Phe Val  Leu Leu Phe Phe Val  Gly Cys Gly 
    1730                 1735                 1740             


Val Leu  Leu Ser Arg Lys Arg  Arg Arg Gln His Gly  Gln Leu Trp 
    1745                 1750                 1755             


Phe Pro  Glu Gly Phe Lys Val  Ser Glu Ala Ser Lys  Lys Lys Arg 
    1760                 1765                 1770             


Arg Glu  Pro Leu Gly Glu Asp  Ser Val Gly Leu Lys  Pro Leu Lys 
    1775                 1780                 1785             


Asn Ala  Ser Asp Gly Ala Leu  Met Asp Asp Asn Gln  Asn Glu Trp 
    1790                 1795                 1800             


Gly Asp  Glu Asp Leu Glu Thr  Lys Lys Phe Arg Phe  Glu Glu Pro 
    1805                 1810                 1815             


Val Val  Leu Pro Asp Leu Asp  Asp Gln Thr Asp His  Arg Gln Trp 
    1820                 1825                 1830             


Thr Gln  Gln His Leu Asp Ala  Ala Asp Leu Arg Val  Ser Ala Met 
    1835                 1840                 1845             


Ala Pro  Thr Pro Pro Gln Gly  Glu Val Asp Ala Asp  Cys Met Asp 
    1850                 1855                 1860             


Val Asn  Val Arg Gly Pro Asp  Gly Phe Thr Pro Leu  Met Ile Ala 
    1865                 1870                 1875             


Ser Cys  Ser Gly Gly Gly Leu  Glu Thr Gly Asn Ser  Glu Glu Glu 
    1880                 1885                 1890             


Glu Asp  Ala Pro Ala Val Ile  Ser Asp Phe Ile Tyr  Gln Gly Ala 
    1895                 1900                 1905             


Ser Leu  His Asn Gln Thr Asp  Arg Thr Gly Glu Thr  Ala Leu His 
    1910                 1915                 1920             


Leu Ala  Ala Arg Tyr Ser Arg  Ser Asp Ala Ala Lys  Arg Leu Leu 
    1925                 1930                 1935             


Glu Ala  Ser Ala Asp Ala Asn  Ile Gln Asp Asn Met  Gly Arg Thr 
    1940                 1945                 1950             


Pro Leu  His Ala Ala Val Ser  Ala Asp Ala Gln Gly  Val Phe Gln 
    1955                 1960                 1965             


Ile Leu  Leu Arg Asn Arg Ala  Thr Asp Leu Asp Ala  Arg Met His 
    1970                 1975                 1980             


Asp Gly  Thr Thr Pro Leu Ile  Leu Ala Ala Arg Leu  Ala Val Glu 
    1985                 1990                 1995             


Gly Met  Leu Glu Asp Leu Ile  Asn Ser His Ala Asp  Val Asn Ala 
    2000                 2005                 2010             


Val Asp  Asp Leu Gly Lys Ser  Ala Leu His Trp Ala  Ala Ala Val 
    2015                 2020                 2025             


Asn Asn  Val Asp Ala Ala Val  Val Leu Leu Lys Asn  Gly Ala Asn 
    2030                 2035                 2040             


Lys Asp  Met Gln Asn Asn Lys  Glu Glu Thr Pro Leu  Phe Leu Ala 
    2045                 2050                 2055             


Ala Arg  Glu Gly Ser Tyr Glu  Thr Ala Lys Val Leu  Leu Asp His 
    2060                 2065                 2070             


Phe Ala  Asn Arg Asp Ile Thr  Asp His Met Asp Arg  Leu Pro Arg 
    2075                 2080                 2085             


Asp Ile  Ala Gln Glu Arg Met  His His Asp Ile Val  Arg Leu Leu 
    2090                 2095                 2100             


Asp Glu  Tyr Asn Leu Val Arg  Ser Pro Gln Leu His  Gly Thr Ala 
    2105                 2110                 2115             


Leu Gly  Gly Thr Pro Thr Leu  Ser Pro Thr Leu Cys  Ser Pro Asn 
    2120                 2125                 2130             


Gly Tyr  Leu Gly Asn Leu Lys  Ser Ala Thr Gln Gly  Lys Lys Ala 
    2135                 2140                 2145             


Arg Lys  Pro Ser Thr Lys Gly  Leu Ala Cys Ser Ser  Lys Glu Ala 
    2150                 2155                 2160             


Lys Asp  Leu Lys Ala Arg Arg  Lys Lys Ser Gln Asp  Gly Lys Gly 
    2165                 2170                 2175             


Cys Leu  Leu Asp Ser Ser Ser  Met Leu Ser Pro Val  Asp Ser Leu 
    2180                 2185                 2190             


Glu Ser  Pro His Gly Tyr Leu  Ser Asp Val Ala Ser  Pro Pro Leu 
    2195                 2200                 2205             


Leu Pro  Ser Pro Phe Gln Gln  Ser Pro Ser Met Pro  Leu Ser His 
    2210                 2215                 2220             


Leu Pro  Gly Met Pro Asp Thr  His Leu Gly Ile Ser  His Leu Asn 
    2225                 2230                 2235             


Val Ala  Ala Lys Pro Glu Met  Ala Ala Leu Ala Gly  Gly Ser Arg 
    2240                 2245                 2250             


Leu Ala  Phe Glu Pro Pro Pro  Pro Arg Leu Ser His  Leu Pro Val 
    2255                 2260                 2265             


Ala Ser  Ser Ala Ser Thr Val  Leu Ser Thr Asn Gly  Thr Gly Ala 
    2270                 2275                 2280             


Met Asn  Phe Thr Val Gly Ala  Pro Ala Ser Leu Asn  Gly Gln Cys 
    2285                 2290                 2295             


Glu Trp  Leu Pro Arg Leu Gln  Asn Gly Met Val Pro  Ser Gln Tyr 
    2300                 2305                 2310             


Asn Pro  Leu Arg Pro Gly Val  Thr Pro Gly Thr Leu  Ser Thr Gln 
    2315                 2320                 2325             


Ala Ala  Gly Leu Gln His Gly  Met Met Gly Pro Ile  His Ser Ser 
    2330                 2335                 2340             


Leu Ser  Thr Asn Thr Leu Ser  Pro Ile Ile Tyr Gln  Gly Leu Pro 
    2345                 2350                 2355             


Asn Thr  Arg Leu Ala Thr Gln  Pro His Leu Val Gln  Thr Gln Gln 
    2360                 2365                 2370             


Val Gln  Pro Gln Asn Leu Gln  Ile Gln Pro Gln Asn  Leu Gln Pro 
    2375                 2380                 2385             


Pro Ser  Gln Pro His Leu Ser  Val Ser Ser Ala Ala  Asn Gly His 
    2390                 2395                 2400             


Leu Gly  Arg Ser Phe Leu Ser  Gly Glu Pro Ser Gln  Ala Asp Val 
    2405                 2410                 2415             


Gln Pro  Leu Gly Pro Ser Ser  Leu Pro Val His Thr  Ile Leu Pro 
    2420                 2425                 2430             


Gln Glu  Ser Gln Ala Leu Pro  Thr Ser Leu Pro Ser  Ser Met Val 
    2435                 2440                 2445             


Pro Pro  Met Thr Thr Thr Gln  Phe Leu Thr Pro Pro  Ser Gln His 
    2450                 2455                 2460             


Ser Tyr  Ser Ser Ser Pro Val  Asp Asn Thr Pro Ser  His Gln Leu 
    2465                 2470                 2475             


Gln Val  Pro Glu His Pro Phe  Leu Thr Pro Ser Pro  Glu Ser Pro 
    2480                 2485                 2490             


Asp Gln  Trp Ser Ser Ser Ser  Arg His Ser Asn Ile  Ser Asp Trp 
    2495                 2500                 2505             


Ser Glu  Gly Ile Ser Ser Pro  Pro Thr Ser Met Pro  Ser Gln Ile 
    2510                 2515                 2520             


Thr His  Ile Pro Glu Ala Phe  Lys 
    2525                 2530     


<210>  138
<211>  370
<212>  PRT
<213>  Mus musculus

<400>  138

Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Val Gly Ser Asn Pro 
1               5                   10                  15      


Cys Tyr Asn Gln Gly Thr Cys Glu Pro Thr Ser Glu Asn Pro Phe Tyr 
            20                  25                  30          


Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu Cys His Ile Leu 
        35                  40                  45              


Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro Pro Gln 
    50                  55                  60                  


Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala Gly Asn 
65                  70                  75                  80  


Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly 
                85                  90                  95      


Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys Thr Gln 
            100                 105                 110         


Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp Ser Gln 
        115                 120                 125             


Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Leu Thr 
    130                 135                 140                 


Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His Phe 
145                 150                 155                 160 


Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu Trp 
                165                 170                 175     


Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala Gly 
            180                 185                 190         


Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg Asn Asn 
        195                 200                 205             


Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr Asn Val 
    210                 215                 220                 


Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro Tyr Tyr 
225                 230                 235                 240 


Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser Thr Val 
                245                 250                 255     


Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly Arg Gln 
            260                 265                 270         


Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val Tyr Leu 
        275                 280                 285             


Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys Phe Gln 
    290                 295                 300                 


Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly 
305                 310                 315                 320 


Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro Val 
                325                 330                 335     


Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala Ala 
            340                 345                 350         


Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg 
        355                 360                 365             


Lys Arg 
    370 


<210>  139
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  139

Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Leu Gly Gly Asn Pro 
1               5                   10                  15      


Cys Tyr Asn Gln Gly Thr Cys Glu Pro Thr Ser Glu Ser Pro Phe Tyr 
            20                  25                  30          


Arg Cys Leu Cys Pro Ala Lys Phe Asn Gly Leu Leu Cys His Ile Leu 
        35                  40                  45              


Asp Tyr Ser Phe Gly Gly Gly Ala Gly Arg Asp Ile Pro Pro Pro Leu 
    50                  55                  60                  


Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Glu Asp Ala Gly Asn 
65                  70                  75                  80  


Lys Val Cys Ser Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly 
                85                  90                  95      


Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys Thr Gln 
            100                 105                 110         


Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp Ser Gln 
        115                 120                 125             


Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Arg Ala 
    130                 135                 140                 


Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His Phe 
145                 150                 155                 160 


Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu Trp 
                165                 170                 175     


Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala Gly 
            180                 185                 190         


Thr Leu Val Val Val Val Leu Met Pro Pro Glu Gln Leu Arg Asn Ser 
        195                 200                 205             


Ser Phe His Phe Leu Arg Glu Leu Ser Arg Val Leu His Thr Asn Val 
    210                 215                 220                 


Val Phe Lys Arg Asp Ala His Gly Gln Gln Met Ile Phe Pro Tyr Tyr 
225                 230                 235                 240 


Gly Arg Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ala Ala Glu 
                245                 250                 255     


Gly Trp Ala Ala Pro Asp Ala Leu Leu Gly Gln Val Lys Ala Ser Leu 
            260                 265                 270         


Leu Pro Gly Gly Ser Glu Gly Gly Arg Arg Arg Arg Glu Leu Asp Pro 
        275                 280                 285             


Met Asp Val Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln 
    290                 295                 300                 


Cys Val Gln Ala Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala 
305                 310                 315                 320 


Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr 
                325                 330                 335     


Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro Pro Pro Pro Ala 
            340                 345                 350         


Gln Leu His Phe Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe 
        355                 360                 365             


Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg 
    370                 375                 380 


<210>  140
<211>  365
<212>  PRT
<213>  Bos taurus

<400>  140

Pro Glu Cys Gln Phe Pro Ala Ser Ser Pro Cys Val Gly Gly Asn Pro 
1               5                   10                  15      


Cys Tyr Asn Gln Gly Val Cys Glu Pro Thr Ala Glu Ser Pro Phe Tyr 
            20                  25                  30          


Arg Cys Arg Cys Pro Ala Lys Phe Asn Gly Leu Leu Cys His Ile Leu 
        35                  40                  45              


Asp Tyr Ser Phe Gly Gly Gly Val Gly Leu Asp Ile Pro Pro Pro Gln 
    50                  55                  60                  


Ile Glu Glu Thr Cys Glu Leu Pro Gly Cys Arg Glu Glu Ala Gly Asn 
65                  70                  75                  80  


Lys Val Cys Ser Leu Gln Cys Asn Ser His Ala Cys Gly Trp Asp Gly 
                85                  90                  95      


Gly Asp Cys Ser Leu Asp Phe Asp Asp Pro Trp Gln Asn Cys Thr Gln 
            100                 105                 110         


Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asn Gly Arg Cys Asp Ser Gln 
        115                 120                 125             


Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Arg Ala 
    130                 135                 140                 


Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His Phe 
145                 150                 155                 160 


Arg Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu Trp 
                165                 170                 175     


Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala Gly 
            180                 185                 190         


Thr Leu Val Leu Val Val Leu Met Pro Pro Glu Gln Leu Arg Asn Arg 
        195                 200                 205             


Ser Leu His Phe Leu Arg Glu Leu Ser Arg Leu Leu His Thr Asn Val 
    210                 215                 220                 


Val Phe Lys Arg Asp Ala Ser Gly Gln Gln Met Ile Phe Pro Tyr Tyr 
225                 230                 235                 240 


Gly Arg Ala Pro Leu Pro Ala Gly Glu Arg Ser Glu Glu Cys Arg Cys 
                245                 250                 255     


Glu His His Ala Cys Pro Ala Gly Ala Gly Gln Gly Glu Pro Ser Gly 
            260                 265                 270         


Pro Leu Cys Thr Ser Arg Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg 
        275                 280                 285             


Gln Cys Val Gln Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val 
    290                 295                 300                 


Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro 
305                 310                 315                 320 


Tyr Lys Ile Glu Ala Val Gln Ser Glu Thr Val Glu Pro Pro Pro Pro 
                325                 330                 335     


Pro Pro Leu His Phe Met Tyr Val Ala Val Val Ala Phe Val Leu Leu 
            340                 345                 350         


Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg 
        355                 360                 365 


<210>  141
<211>  333
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  141

Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro 
1               5                   10                  15      


Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala 
            20                  25                  30          


Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp 
        35                  40                  45              


Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys 
    50                  55                  60                  


Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp 
65                  70                  75                  80  


Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln 
                85                  90                  95      


Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp 
            100                 105                 110         


His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys 
        115                 120                 125             


Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala 
    130                 135                 140                 


Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg 
145                 150                 155                 160 


Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr 
                165                 170                 175     


Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro 
            180                 185                 190         


Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser 
        195                 200                 205             


Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly 
    210                 215                 220                 


Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val 
225                 230                 235                 240 


Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys 
                245                 250                 255     


Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser 
            260                 265                 270         


Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu 
        275                 280                 285             


Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala 
    290                 295                 300                 


Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu 
305                 310                 315                 320 


Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu 
                325                 330             


<210>  142
<211>  370
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  142

Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu Pro 
1               5                   10                  15      


Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe Asn 
            20                  25                  30          


Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly 
        35                  40                  45              


Arg Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu 
    50                  55                  60                  


Cys Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn 
65                  70                  75                  80  


His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp 
                85                  90                  95      


Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser 
            100                 105                 110         


Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp 
        115                 120                 125             


Gly Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp 
    130                 135                 140                 


Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys 
145                 150                 155                 160 


Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val 
                165                 170                 175     


Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro 
            180                 185                 190         


Pro Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser 
        195                 200                 205             


His Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln 
    210                 215                 220                 


Gln Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His 
225                 230                 235                 240 


Pro Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro 
                245                 250                 255     


Gly Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile 
            260                 265                 270         


Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln 
        275                 280                 285             


Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu 
    290                 295                 300                 


Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu 
305                 310                 315                 320 


Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His 
                325                 330                 335     


Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly 
            340                 345                 350         


Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln 
        355                 360                 365             


Lys Leu 
    370 


<210>  143
<211>  787
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  143

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Ile Leu 
        195                 200                 205             


Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro Pro Gln 
    210                 215                 220                 


Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala Gly Asn 
225                 230                 235                 240 


Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly 
                245                 250                 255     


Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys Thr Gln 
            260                 265                 270         


Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp Ser Gln 
        275                 280                 285             


Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Leu Thr 
    290                 295                 300                 


Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His Phe 
305                 310                 315                 320 


Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu Trp 
                325                 330                 335     


Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala Gly 
            340                 345                 350         


Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg Asn Asn 
        355                 360                 365             


Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr Asn Val 
    370                 375                 380                 


Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro Tyr Tyr 
385                 390                 395                 400 


Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser Thr Val 
                405                 410                 415     


Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly Arg Gln 
            420                 425                 430         


Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val Tyr Leu 
        435                 440                 445             


Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys Phe Gln 
    450                 455                 460                 


Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly 
465                 470                 475                 480 


Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro Val 
                485                 490                 495     


Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala Ala 
            500                 505                 510         


Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg 
        515                 520                 525             


Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu Met Ser Arg Leu Asp 
    530                 535                 540                 


Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val Gly 
545                 550                 555                 560 


Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu 
                565                 570                 575     


Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp 
            580                 585                 590         


Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr His Phe Cys Pro 
        595                 600                 605             


Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser 
    610                 615                 620                 


Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu 
625                 630                 635                 640 


Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu 
                645                 650                 655     


Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala 
            660                 665                 670         


Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp Gln 
        675                 680                 685             


Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser 
    690                 695                 700                 


Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln Gly 
705                 710                 715                 720 


Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu 
                725                 730                 735     


Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu Asp 
            740                 745                 750         


Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp 
        755                 760                 765             


Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
    770                 775                 780                 


Leu Pro Gly 
785         


<210>  144
<211>  889
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  144

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Ala 
            20                  25                  30          


Gln Pro Ala Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly 
        35                  40                  45              


Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr 
    50                  55                  60                  


Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys 
65                  70                  75                  80  


Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala 
                85                  90                  95      


Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr 
            100                 105                 110         


Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp 
        115                 120                 125             


Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser 
    130                 135                 140                 


Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly 
145                 150                 155                 160 


Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp 
                165                 170                 175     


Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro 
            180                 185                 190         


Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala 
        195                 200                 205             


Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val 
    210                 215                 220                 


Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys 
225                 230                 235                 240 


Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met 
                245                 250                 255     


Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp 
            260                 265                 270         


Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His 
        275                 280                 285             


Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr 
    290                 295                 300                 


Gly Gly Trp Lys Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg 
305                 310                 315                 320 


Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys 
                325                 330                 335     


Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His 
            340                 345                 350         


Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro 
        355                 360                 365             


Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp 
    370                 375                 380                 


Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly 
385                 390                 395                 400 


Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln 
                405                 410                 415     


Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn 
            420                 425                 430         


Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro 
        435                 440                 445             


Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro 
    450                 455                 460                 


Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His 
465                 470                 475                 480 


Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln 
                485                 490                 495     


Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro 
            500                 505                 510         


Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly 
        515                 520                 525             


Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg 
    530                 535                 540                 


Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser 
545                 550                 555                 560 


Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly 
                565                 570                 575     


Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala 
            580                 585                 590         


Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu 
        595                 600                 605             


Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys 
    610                 615                 620                 


Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys 
625                 630                 635                 640 


Leu Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu 
                645                 650                 655     


Leu Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala 
            660                 665                 670         


Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn 
        675                 680                 685             


Lys Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His 
    690                 695                 700                 


His Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu 
705                 710                 715                 720 


Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp 
                725                 730                 735     


Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu 
            740                 745                 750         


Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu 
        755                 760                 765             


Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly 
    770                 775                 780                 


Cys Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu 
785                 790                 795                 800 


Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu 
                805                 810                 815     


Leu Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu 
            820                 825                 830         


Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly 
        835                 840                 845             


Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp 
    850                 855                 860                 


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp 
865                 870                 875                 880 


Asp Phe Asp Leu Asp Met Leu Pro Gly 
                885                 


<210>  145
<211>  854
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  145

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro 
        275                 280                 285             


Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
    290                 295                 300                 


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
305                 310                 315                 320 


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
                325                 330                 335     


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
            340                 345                 350         


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
        355                 360                 365             


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
    370                 375                 380                 


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
385                 390                 395                 400 


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
                405                 410                 415     


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
            420                 425                 430         


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
        435                 440                 445             


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
    450                 455                 460                 


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
465                 470                 475                 480 


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
                485                 490                 495     


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
            500                 505                 510         


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
        515                 520                 525             


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
    530                 535                 540                 


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
545                 550                 555                 560 


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
                565                 570                 575     


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
            580                 585                 590         


Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu Met Ser 
        595                 600                 605             


Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn 
    610                 615                 620                 


Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu 
625                 630                 635                 640 


Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala 
                645                 650                 655     


Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr His 
            660                 665                 670         


Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn 
        675                 680                 685             


Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys 
    690                 695                 700                 


Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu 
705                 710                 715                 720 


Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala 
                725                 730                 735     


Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu 
            740                 745                 750         


Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr 
        755                 760                 765             


Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp 
    770                 775                 780                 


His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile 
785                 790                 795                 800 


Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp 
                805                 810                 815     


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp 
            820                 825                 830         


Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp 
        835                 840                 845             


Leu Asp Met Leu Pro Gly 
    850                 


<210>  146
<211>  891
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  146

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu 
        275                 280                 285             


Pro Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe 
    290                 295                 300                 


Asn Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala 
305                 310                 315                 320 


Gly Arg Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro 
                325                 330                 335     


Glu Cys Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn 
            340                 345                 350         


Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn 
        355                 360                 365             


Asp Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe 
    370                 375                 380                 


Ser Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe 
385                 390                 395                 400 


Asp Gly Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr 
                405                 410                 415     


Asp Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly 
            420                 425                 430         


Cys Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His 
        435                 440                 445             


Val Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu 
    450                 455                 460                 


Pro Pro Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu 
465                 470                 475                 480 


Ser His Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly 
                485                 490                 495     


Gln Gln Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys 
            500                 505                 510         


His Pro Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu 
        515                 520                 525             


Pro Gly Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp 
    530                 535                 540                 


Ile Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val 
545                 550                 555                 560 


Gln Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe 
                565                 570                 575     


Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile 
            580                 585                 590         


Glu Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu 
        595                 600                 605             


His Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
    610                 615                 620                 


Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile 
625                 630                 635                 640 


Gln Lys Leu Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala 
                645                 650                 655     


Leu Glu Leu Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys 
            660                 665                 670         


Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val 
        675                 680                 685             


Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp 
    690                 695                 700                 


Arg His His Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp 
705                 710                 715                 720 


Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His 
                725                 730                 735     


Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln 
            740                 745                 750         


Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe 
        755                 760                 765             


Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr 
    770                 775                 780                 


Leu Gly Cys Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu 
785                 790                 795                 800 


Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala 
                805                 810                 815     


Ile Glu Leu Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly 
            820                 825                 830         


Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser 
        835                 840                 845             


Gly Gly Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro 
    850                 855                 860                 


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
865                 870                 875                 880 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly 
                885                 890     


<210>  147
<211>  891
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  147

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gln 
            20                  25                  30          


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser 
        35                  40                  45              


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
    50                  55                  60                  


Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
65                  70                  75                  80  


Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg 
                85                  90                  95      


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            100                 105                 110         


Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
        115                 120                 125             


Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ser Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met 
                165                 170                 175     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser 
            180                 185                 190         


Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro 
        195                 200                 205             


Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser 
225                 230                 235                 240 


Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
                245                 250                 255     


Lys His Pro Leu Thr Tyr Gly Ala Gly Thr Lys Leu Glu Ile Lys Ala 
            260                 265                 270         


Ser Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu 
        275                 280                 285             


Pro Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe 
    290                 295                 300                 


Asn Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala 
305                 310                 315                 320 


Gly Arg Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro 
                325                 330                 335     


Glu Cys Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn 
            340                 345                 350         


Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn 
        355                 360                 365             


Asp Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe 
    370                 375                 380                 


Ser Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe 
385                 390                 395                 400 


Asp Gly Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr 
                405                 410                 415     


Asp Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly 
            420                 425                 430         


Cys Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His 
        435                 440                 445             


Val Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu 
    450                 455                 460                 


Pro Pro Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu 
465                 470                 475                 480 


Ser His Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly 
                485                 490                 495     


Gln Gln Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys 
            500                 505                 510         


His Pro Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu 
        515                 520                 525             


Pro Gly Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp 
    530                 535                 540                 


Ile Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val 
545                 550                 555                 560 


Gln Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe 
                565                 570                 575     


Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile 
            580                 585                 590         


Glu Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu 
        595                 600                 605             


His Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
    610                 615                 620                 


Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile 
625                 630                 635                 640 


Gln Lys Leu Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala 
                645                 650                 655     


Leu Glu Leu Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys 
            660                 665                 670         


Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val 
        675                 680                 685             


Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp 
    690                 695                 700                 


Arg His His Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp 
705                 710                 715                 720 


Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His 
                725                 730                 735     


Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln 
            740                 745                 750         


Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe 
        755                 760                 765             


Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr 
    770                 775                 780                 


Leu Gly Cys Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu 
785                 790                 795                 800 


Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala 
                805                 810                 815     


Ile Glu Leu Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly 
            820                 825                 830         


Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser 
        835                 840                 845             


Gly Gly Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro 
    850                 855                 860                 


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
865                 870                 875                 880 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly 
                885                 890     


<210>  148
<211>  871
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  148

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gln 
            20                  25                  30          


Val Gln Leu Gln Gln Gln Val Gln Leu Gln Glu Ser Gly Gly Asp Leu 
        35                  40                  45              


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
    50                  55                  60                  


Thr Phe Ser His Tyr Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys 
65                  70                  75                  80  


Arg Leu Glu Trp Val Ala Thr Ile Gly Ser Arg Gly Thr Tyr Thr His 
                85                  90                  95      


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp 
            100                 105                 110         


Lys Asn Ala Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr 
        115                 120                 125             


Ala Met Tyr Tyr Cys Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr Gly Asn 
    130                 135                 140                 


Thr Tyr Tyr Tyr Ser Ala Met Asp Tyr Trp Gly Gln Gly Ala Ser Val 
145                 150                 155                 160 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                165                 170                 175     


Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Phe Leu Ala Val 
            180                 185                 190         


Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val 
        195                 200                 205             


Asp Asn Tyr Gly Phe Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly 
    210                 215                 220                 


Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly Ser Gly 
225                 230                 235                 240 


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu 
                245                 250                 255     


Asn Ile His Pro Val Glu Glu Asp Asp Pro Ala Met Tyr Phe Cys Gln 
            260                 265                 270         


Gln Thr Lys Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        275                 280                 285             


Ile Lys Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile 
    290                 295                 300                 


Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val 
305                 310                 315                 320 


Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys 
                325                 330                 335     


Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys 
            340                 345                 350         


Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His 
        355                 360                 365             


Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp 
    370                 375                 380                 


Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys 
385                 390                 395                 400 


Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala 
                405                 410                 415     


Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg 
            420                 425                 430         


Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln 
        435                 440                 445             


Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu 
    450                 455                 460                 


His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile 
465                 470                 475                 480 


Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys 
                485                 490                 495     


Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser 
            500                 505                 510         


Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser 
        515                 520                 525             


Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser 
    530                 535                 540                 


Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu 
545                 550                 555                 560 


Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys 
                565                 570                 575     


Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr 
            580                 585                 590         


Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val 
        595                 600                 605             


Leu Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu Met 
    610                 615                 620                 


Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu 
625                 630                 635                 640 


Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys 
                645                 650                 655     


Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg 
            660                 665                 670         


Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr 
        675                 680                 685             


His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn 
    690                 695                 700                 


Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala 
705                 710                 715                 720 


Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu 
                725                 730                 735     


Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn 
            740                 745                 750         


Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val 
        755                 760                 765             


Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro 
    770                 775                 780                 


Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe 
785                 790                 795                 800 


Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile 
                805                 810                 815     


Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala 
            820                 825                 830         


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu 
        835                 840                 845             


Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe 
    850                 855                 860                 


Asp Leu Asp Met Leu Pro Gly 
865                 870     


<210>  149
<211>  873
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  149

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly 
            20                  25                  30          


Ser Gln Val Gln Leu Gln Gln Gln Val Gln Leu Gln Glu Ser Gly Gly 
        35                  40                  45              


Asp Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
    50                  55                  60                  


Gly Phe Thr Phe Ser His Tyr Gly Met Ser Trp Val Arg Gln Thr Pro 
65                  70                  75                  80  


Asp Lys Arg Leu Glu Trp Val Ala Thr Ile Gly Ser Arg Gly Thr Tyr 
                85                  90                  95      


Thr His Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            100                 105                 110         


Asn Asp Lys Asn Ala Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu 
        115                 120                 125             


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Ser Glu Phe Tyr Tyr Tyr 
    130                 135                 140                 


Gly Asn Thr Tyr Tyr Tyr Ser Ala Met Asp Tyr Trp Gly Gln Gly Ala 
145                 150                 155                 160 


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Phe Leu 
            180                 185                 190         


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        195                 200                 205             


Ser Val Asp Asn Tyr Gly Phe Ser Phe Met Asn Trp Phe Gln Gln Lys 
    210                 215                 220                 


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ile Ser Asn Arg Gly 
225                 230                 235                 240 


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                245                 250                 255     


Ser Leu Asn Ile His Pro Val Glu Glu Asp Asp Pro Ala Met Tyr Phe 
            260                 265                 270         


Cys Gln Gln Thr Lys Glu Val Pro Trp Thr Phe Gly Gly Gly Thr Lys 
        275                 280                 285             


Leu Glu Ile Lys Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg 
    290                 295                 300                 


Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys 
305                 310                 315                 320 


Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His 
                325                 330                 335     


Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro 
            340                 345                 350         


Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp 
        355                 360                 365             


Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly 
    370                 375                 380                 


Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln 
385                 390                 395                 400 


Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn 
                405                 410                 415     


Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro 
            420                 425                 430         


Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro 
        435                 440                 445             


Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His 
    450                 455                 460                 


Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln 
465                 470                 475                 480 


Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro 
                485                 490                 495     


Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly 
            500                 505                 510         


Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg 
        515                 520                 525             


Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser 
    530                 535                 540                 


Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly 
545                 550                 555                 560 


Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala 
                565                 570                 575     


Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu 
            580                 585                 590         


Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys 
        595                 600                 605             


Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys 
    610                 615                 620                 


Leu Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu 
625                 630                 635                 640 


Leu Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala 
                645                 650                 655     


Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn 
            660                 665                 670         


Lys Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His 
        675                 680                 685             


His Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu 
    690                 695                 700                 


Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp 
705                 710                 715                 720 


Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu 
                725                 730                 735     


Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu 
            740                 745                 750         


Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly 
        755                 760                 765             


Cys Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu 
    770                 775                 780                 


Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu 
785                 790                 795                 800 


Leu Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu 
                805                 810                 815     


Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly 
            820                 825                 830         


Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp 
        835                 840                 845             


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp 
    850                 855                 860                 


Asp Phe Asp Leu Asp Met Leu Pro Gly 
865                 870             


<210>  150
<211>  739
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  150

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
        35                  40                  45              


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr 
    50                  55                  60                  


Ser Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
65                  70                  75                  80  


Val Ala Arg Ile Thr Trp Ser Ala Gly Tyr Thr Ala Tyr Ser Asp Ser 
                85                  90                  95      


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val 
            100                 105                 110         


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
        115                 120                 125             


Cys Ala Ser Arg Ser Ala Gly Tyr Ser Ser Ser Leu Thr Arg Arg Glu 
    130                 135                 140                 


Asp Tyr Ala Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ile Leu 
145                 150                 155                 160 


Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro Pro Gln 
                165                 170                 175     


Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala Gly Asn 
            180                 185                 190         


Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly 
        195                 200                 205             


Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys Thr Gln 
    210                 215                 220                 


Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp Ser Gln 
225                 230                 235                 240 


Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Leu Thr 
                245                 250                 255     


Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His Phe 
            260                 265                 270         


Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu Trp 
        275                 280                 285             


Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala Gly 
    290                 295                 300                 


Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg Asn Asn 
305                 310                 315                 320 


Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr Asn Val 
                325                 330                 335     


Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro Tyr Tyr 
            340                 345                 350         


Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser Thr Val 
        355                 360                 365             


Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly Arg Gln 
    370                 375                 380                 


Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val Tyr Leu 
385                 390                 395                 400 


Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys Phe Gln 
                405                 410                 415     


Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly 
            420                 425                 430         


Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro Val 
        435                 440                 445             


Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala Ala 
    450                 455                 460                 


Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg 
465                 470                 475                 480 


Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu Met Ser Arg Leu Asp 
                485                 490                 495     


Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val Gly 
            500                 505                 510         


Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu 
        515                 520                 525             


Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp 
    530                 535                 540                 


Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr His Phe Cys Pro 
545                 550                 555                 560 


Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser 
                565                 570                 575     


Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu 
            580                 585                 590         


Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu 
        595                 600                 605             


Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala 
    610                 615                 620                 


Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp Gln 
625                 630                 635                 640 


Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser 
                645                 650                 655     


Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln Gly 
            660                 665                 670         


Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu 
        675                 680                 685             


Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu Asp 
    690                 695                 700                 


Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp 
705                 710                 715                 720 


Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
                725                 730                 735     


Leu Pro Gly 
            


<210>  151
<211>  740
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  151

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
        35                  40                  45              


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Ser Met 
    50                  55                  60                  


Ala Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
65                  70                  75                  80  


Val Ala Gly Ile Ser Arg Ser Ala Gly Ser Ala Val His Ala Asp Ser 
                85                  90                  95      


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu 
            100                 105                 110         


Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr 
        115                 120                 125             


Cys Ala Val Arg Thr Ser Gly Phe Phe Gly Ser Ile Pro Arg Thr Gly 
    130                 135                 140                 


Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ile 
145                 150                 155                 160 


Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro Pro 
                165                 170                 175     


Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala Gly 
            180                 185                 190         


Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp 
        195                 200                 205             


Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys Thr 
    210                 215                 220                 


Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp Ser 
225                 230                 235                 240 


Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Leu 
                245                 250                 255     


Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His 
            260                 265                 270         


Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu 
        275                 280                 285             


Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala 
    290                 295                 300                 


Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg Asn 
305                 310                 315                 320 


Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr Asn 
                325                 330                 335     


Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro Tyr 
            340                 345                 350         


Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser Thr 
        355                 360                 365             


Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly Arg 
    370                 375                 380                 


Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val Tyr 
385                 390                 395                 400 


Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys Phe 
                405                 410                 415     


Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu 
            420                 425                 430         


Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro 
        435                 440                 445             


Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala 
    450                 455                 460                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
465                 470                 475                 480 


Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu Met Ser Arg Leu 
                485                 490                 495     


Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val 
            500                 505                 510         


Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val 
        515                 520                 525             


Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu 
    530                 535                 540                 


Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr His Phe Cys 
545                 550                 555                 560 


Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys 
                565                 570                 575     


Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His 
            580                 585                 590         


Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln 
        595                 600                 605             


Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr 
    610                 615                 620                 


Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp 
625                 630                 635                 640 


Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp 
                645                 650                 655     


Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln 
            660                 665                 670         


Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly 
        675                 680                 685             


Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu 
    690                 695                 700                 


Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe 
705                 710                 715                 720 


Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
                725                 730                 735     


Met Leu Pro Gly 
            740 


<210>  152
<211>  740
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  152

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly 
        35                  40                  45              


Gly Ser Leu Lys Leu Ser Cys Thr Ala Ser Val Arg Thr Leu Ser Tyr 
    50                  55                  60                  


Tyr His Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
65                  70                  75                  80  


Val Ala Gly Ile His Arg Ser Gly Glu Ser Thr Phe Tyr Ala Asp Ser 
                85                  90                  95      


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
            100                 105                 110         


His Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
        115                 120                 125             


Cys Ala Gln Arg Val Arg Gly Phe Phe Gly Pro Leu Arg Ser Thr Pro 
    130                 135                 140                 


Ser Trp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ile 
145                 150                 155                 160 


Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro Pro 
                165                 170                 175     


Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala Gly 
            180                 185                 190         


Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp 
        195                 200                 205             


Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys Thr 
    210                 215                 220                 


Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp Ser 
225                 230                 235                 240 


Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Leu 
                245                 250                 255     


Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His 
            260                 265                 270         


Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu 
        275                 280                 285             


Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala 
    290                 295                 300                 


Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg Asn 
305                 310                 315                 320 


Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr Asn 
                325                 330                 335     


Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro Tyr 
            340                 345                 350         


Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser Thr 
        355                 360                 365             


Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly Arg 
    370                 375                 380                 


Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val Tyr 
385                 390                 395                 400 


Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys Phe 
                405                 410                 415     


Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu 
            420                 425                 430         


Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro 
        435                 440                 445             


Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala 
    450                 455                 460                 


Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser 
465                 470                 475                 480 


Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu Met Ser Arg Leu 
                485                 490                 495     


Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val 
            500                 505                 510         


Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val 
        515                 520                 525             


Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu 
    530                 535                 540                 


Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His Thr His Phe Cys 
545                 550                 555                 560 


Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys 
                565                 570                 575     


Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His 
            580                 585                 590         


Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln 
        595                 600                 605             


Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr 
    610                 615                 620                 


Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp 
625                 630                 635                 640 


Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp 
                645                 650                 655     


Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln 
            660                 665                 670         


Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly 
        675                 680                 685             


Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu 
    690                 695                 700                 


Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe 
705                 710                 715                 720 


Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
                725                 730                 735     


Met Leu Pro Gly 
            740 


<210>  153
<211>  882
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  153

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Met 
            20                  25                  30          


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Ala Gly 
        35                  40                  45              


Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr 
    50                  55                  60                  


Ser Ala Met Ala Trp Phe Arg Gln Ala Pro Gly Arg Glu Arg Glu Phe 
65                  70                  75                  80  


Val Ala Ala Ile Thr Trp Thr Val Gly Asn Thr Ile Leu Gly Asp Ser 
                85                  90                  95      


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Ala Lys Asn Thr Val 
            100                 105                 110         


Asp Leu Gln Met Asp Asn Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
        115                 120                 125             


Cys Ser Ala Arg Ser Arg Gly Tyr Val Leu Ser Val Leu Arg Ser Val 
    130                 135                 140                 


Asp Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Gly 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala 
                165                 170                 175     


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
            180                 185                 190         


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Asn Tyr 
        195                 200                 205             


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
    210                 215                 220                 


Ala Ala Ile Ser Trp Thr Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 
225                 230                 235                 240 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Thr Val Tyr 
                245                 250                 255     


Val Gln Met Asn Ser Leu Ile Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
            260                 265                 270         


Ala Ala Val Arg Ala Arg Ser Phe Ser Asp Thr Tyr Ser Arg Val Asn 
        275                 280                 285             


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ile Leu Asp 
    290                 295                 300                 


Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro Pro Gln Ile 
305                 310                 315                 320 


Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp Ala Gly Asn Lys 
                325                 330                 335     


Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly 
            340                 345                 350         


Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys Thr Gln Ser 
        355                 360                 365             


Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys Asp Ser Gln Cys 
    370                 375                 380                 


Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Leu Thr Glu 
385                 390                 395                 400 


Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His Phe Ser 
                405                 410                 415     


Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu Trp Asp 
            420                 425                 430         


Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala Gly Thr 
        435                 440                 445             


Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu Arg Asn Asn Ser 
    450                 455                 460                 


Phe His Phe Leu Arg Glu Leu Ser His Val Leu His Thr Asn Val Val 
465                 470                 475                 480 


Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe Pro Tyr Tyr Gly 
                485                 490                 495     


His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg Ser Thr Val Gly 
            500                 505                 510         


Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly Arg Gln Arg 
        515                 520                 525             


Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile Val Tyr Leu Glu 
    530                 535                 540                 


Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln Cys Phe Gln Ser 
545                 550                 555                 560 


Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser 
                565                 570                 575     


Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro Val Glu 
            580                 585                 590         


Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala Ala Ala 
        595                 600                 605             


Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys 
    610                 615                 620                 


Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu Met Ser Arg Leu Asp Lys 
625                 630                 635                 640 


Ser Lys Val Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val Gly Ile 
                645                 650                 655     


Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln 
            660                 665                 670         


Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala 
        675                 680                 685             


Leu Ala Ile Glu Met Leu Asp Arg His His Thr His Phe Cys Pro Leu 
    690                 695                 700                 


Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Phe 
705                 710                 715                 720 


Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu Gly 
                725                 730                 735     


Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala 
            740                 745                 750         


Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu 
        755                 760                 765             


Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp Gln Glu 
    770                 775                 780                 


His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met 
785                 790                 795                 800 


Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln Gly Ala 
                805                 810                 815     


Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu 
            820                 825                 830         


Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu Asp Asp 
        835                 840                 845             


Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu 
    850                 855                 860                 


Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
865                 870                 875                 880 


Pro Gly 
        


<210>  154
<211>  815
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  154

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val 
            20                  25                  30          


Trp Ala Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser 
        35                  40                  45              


Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val 
    50                  55                  60                  


Val Thr Glu Gly Asp Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
65                  70                  75                  80  


Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr 
                85                  90                  95      


Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp 
            100                 105                 110         


Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
        115                 120                 125             


Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly 
    130                 135                 140                 


Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
145                 150                 155                 160 


Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro 
                165                 170                 175     


Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Glu Gln Lys Leu Ile 
            180                 185                 190         


Ser Glu Glu Asp Leu Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln 
        195                 200                 205             


Gly Thr Cys Glu Pro Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys 
    210                 215                 220                 


Pro Ala Lys Phe Asn Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe 
225                 230                 235                 240 


Thr Gly Gly Ala Gly Arg Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala 
                245                 250                 255     


Cys Glu Leu Pro Glu Cys Gln Val Asp Ala Gly Asn Lys Val Cys Asn 
            260                 265                 270         


Leu Gln Cys Asn Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser 
        275                 280                 285             


Leu Asn Phe Asn Asp Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys 
    290                 295                 300                 


Trp Lys Tyr Phe Ser Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala 
305                 310                 315                 320 


Gly Cys Leu Phe Asp Gly Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys 
                325                 330                 335     


Asn Pro Leu Tyr Asp Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His 
            340                 345                 350         


Cys Asp Gln Gly Cys Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp 
        355                 360                 365             


Cys Ala Glu His Val Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Leu 
    370                 375                 380                 


Val Val Leu Leu Pro Pro Asp Gln Leu Arg Asn Asn Ser Phe His Phe 
385                 390                 395                 400 


Leu Arg Glu Leu Ser His Val Leu His Thr Asn Val Val Phe Lys Arg 
                405                 410                 415     


Asp Ala Gln Gly Gln Gln Met Ile Phe Pro Tyr Tyr Gly His Glu Glu 
            420                 425                 430         


Glu Leu Arg Lys His Pro Ile Lys Arg Ser Thr Val Gly Trp Ala Thr 
        435                 440                 445             


Ser Ser Leu Leu Pro Gly Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu 
    450                 455                 460                 


Asp Pro Met Asp Ile Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn 
465                 470                 475                 480 


Arg Gln Cys Val Gln Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp 
                485                 490                 495     


Val Ala Ala Phe Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile 
            500                 505                 510         


Pro Tyr Lys Ile Glu Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu 
        515                 520                 525             


Pro Ser Gln Leu His Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu 
    530                 535                 540                 


Leu Phe Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg 
545                 550                 555                 560 


Gln Leu Cys Ile Gln Lys Leu Met Ser Arg Leu Asp Lys Ser Lys Val 
                565                 570                 575     


Ile Asn Ser Ala Leu Glu Leu Leu Asn Glu Val Gly Ile Glu Gly Leu 
            580                 585                 590         


Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu 
        595                 600                 605             


Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Ala Ile 
    610                 615                 620                 


Glu Met Leu Asp Arg His His Thr His Phe Cys Pro Leu Glu Gly Glu 
625                 630                 635                 640 


Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala 
                645                 650                 655     


Leu Leu Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro 
            660                 665                 670         


Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys 
        675                 680                 685             


Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val 
    690                 695                 700                 


Gly His Phe Thr Leu Gly Cys Val Leu Glu Asp Gln Glu His Gln Val 
705                 710                 715                 720 


Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro Leu 
                725                 730                 735     


Leu Arg Gln Ala Ile Glu Leu Phe Asp His Gln Gly Ala Glu Pro Ala 
            740                 745                 750         


Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu 
        755                 760                 765             


Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu 
    770                 775                 780                 


Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
785                 790                 795                 800 


Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly 
                805                 810                 815 


<210>  155
<211>  817
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  155

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro 
        275                 280                 285             


Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
    290                 295                 300                 


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
305                 310                 315                 320 


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
                325                 330                 335     


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
            340                 345                 350         


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
        355                 360                 365             


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
    370                 375                 380                 


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
385                 390                 395                 400 


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
                405                 410                 415     


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
            420                 425                 430         


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
        435                 440                 445             


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
    450                 455                 460                 


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
465                 470                 475                 480 


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
                485                 490                 495     


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
            500                 505                 510         


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
        515                 520                 525             


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
    530                 535                 540                 


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
545                 550                 555                 560 


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
                565                 570                 575     


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
            580                 585                 590         


Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Gln Lys Leu Met Lys 
        595                 600                 605             


Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu Lys Lys 
    610                 615                 620                 


Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu Lys Asn 
625                 630                 635                 640 


Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro Leu Thr 
                645                 650                 655     


Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu Glu Gln 
            660                 665                 670         


Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile Leu Lys 
        675                 680                 685             


Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu Phe Val 
    690                 695                 700                 


Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala Ser Val 
705                 710                 715                 720 


Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser Ala Thr 
                725                 730                 735     


Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu Thr Val 
            740                 745                 750         


Ser Ala Ala Ala Gly Gly Ser Gly Gly Ser Gly Gly Ser Asp Ala Leu 
        755                 760                 765             


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
    770                 775                 780                 


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
785                 790                 795                 800 


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
                805                 810                 815     


Ser 
    


<210>  156
<211>  809
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  156

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro 
        275                 280                 285             


Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
    290                 295                 300                 


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
305                 310                 315                 320 


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
                325                 330                 335     


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
            340                 345                 350         


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
        355                 360                 365             


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
    370                 375                 380                 


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
385                 390                 395                 400 


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
                405                 410                 415     


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
            420                 425                 430         


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
        435                 440                 445             


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
    450                 455                 460                 


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
465                 470                 475                 480 


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
                485                 490                 495     


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
            500                 505                 510         


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
        515                 520                 525             


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
    530                 535                 540                 


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
545                 550                 555                 560 


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
                565                 570                 575     


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
            580                 585                 590         


Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile Leu Leu Glu Ile Arg 
        595                 600                 605             


Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg Thr Glu Val Ala 
    610                 615                 620                 


Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu Val Ser Gln Tyr 
625                 630                 635                 640 


Glu Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys Gly Gly Ser Gly Gly 
                645                 650                 655     


Ser Gly Gly Ser Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp 
            660                 665                 670         


Ile Cys Arg Leu Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys 
        675                 680                 685             


Ala Lys Cys Leu Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr 
    690                 695                 700                 


Lys Arg Ser Pro Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg 
705                 710                 715                 720 


Leu Glu Arg Leu Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp 
                725                 730                 735     


Leu Asp Met Ile Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu 
            740                 745                 750         


Leu Thr Gly Leu Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr 
        755                 760                 765             


Asp Arg Leu Ala Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln 
    770                 775                 780                 


His Arg Ile Ser Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly 
785                 790                 795                 800 


Gln Arg Gln Leu Thr Val Ser Ala Ala 
                805                 


<210>  157
<211>  756
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  157

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Gln 
            20                  25                  30          


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser 
        35                  40                  45              


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr 
    50                  55                  60                  


Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
65                  70                  75                  80  


Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg 
                85                  90                  95      


Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            100                 105                 110         


Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
        115                 120                 125             


Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
    130                 135                 140                 


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Ser Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met 
                165                 170                 175     


Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser 
            180                 185                 190         


Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro 
        195                 200                 205             


Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly 
    210                 215                 220                 


Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser 
225                 230                 235                 240 


Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser 
                245                 250                 255     


Lys His Pro Leu Thr Tyr Gly Ala Gly Thr Lys Leu Glu Ile Lys Ala 
            260                 265                 270         


Ser Pro Cys Val Gly Ser Asn Pro Cys Tyr Asn Gln Gly Thr Cys Glu 
        275                 280                 285             


Pro Thr Ser Glu Asn Pro Phe Tyr Arg Cys Leu Cys Pro Ala Lys Phe 
    290                 295                 300                 


Asn Gly Leu Leu Cys His Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala 
305                 310                 315                 320 


Gly Arg Asp Ile Pro Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro 
                325                 330                 335     


Glu Cys Gln Val Asp Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn 
            340                 345                 350         


Asn His Ala Cys Gly Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn 
        355                 360                 365             


Asp Pro Trp Lys Asn Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe 
    370                 375                 380                 


Ser Asp Gly His Cys Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe 
385                 390                 395                 400 


Asp Gly Phe Asp Cys Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr 
                405                 410                 415     


Asp Gln Tyr Cys Lys Asp His Phe Ser Asp Gly His Cys Asp Gln Gly 
            420                 425                 430         


Cys Asn Ser Ala Glu Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His 
        435                 440                 445             


Val Pro Glu Arg Leu Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu 
    450                 455                 460                 


Pro Pro Asp Gln Leu Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu 
465                 470                 475                 480 


Ser His Val Leu His Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly 
                485                 490                 495     


Gln Gln Met Ile Phe Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys 
            500                 505                 510         


His Pro Ile Lys Arg Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu 
        515                 520                 525             


Pro Gly Thr Ser Gly Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp 
    530                 535                 540                 


Ile Arg Gly Ser Ile Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val 
545                 550                 555                 560 


Gln Ser Ser Ser Gln Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe 
                565                 570                 575     


Leu Gly Ala Leu Ala Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile 
            580                 585                 590         


Glu Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu 
        595                 600                 605             


His Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val 
    610                 615                 620                 


Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Gln Leu Cys Ile 
625                 630                 635                 640 


Leu Pro Lys Lys Lys Arg Lys Val Asp Ala Leu Asp Asp Phe Asp Leu 
                645                 650                 655     


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
            660                 665                 670         


Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp 
        675                 680                 685             


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Gly Gly Ser Gly 
    690                 695                 700                 


Gly Ser Gly Gly Ser Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu 
705                 710                 715                 720 


Asn Thr Ala Leu Glu Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln 
                725                 730                 735     


Arg Leu Arg Asn Arg Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu 
            740                 745                 750         


Gly Gly Gly Lys 
        755     


<210>  158
<211>  1035
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  158

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro 
        275                 280                 285             


Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
    290                 295                 300                 


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
305                 310                 315                 320 


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
                325                 330                 335     


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
            340                 345                 350         


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
        355                 360                 365             


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
    370                 375                 380                 


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
385                 390                 395                 400 


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
                405                 410                 415     


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
            420                 425                 430         


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
        435                 440                 445             


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
    450                 455                 460                 


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
465                 470                 475                 480 


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
                485                 490                 495     


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
            500                 505                 510         


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
        515                 520                 525             


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
    530                 535                 540                 


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
545                 550                 555                 560 


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
                565                 570                 575     


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
            580                 585                 590         


Leu Ser Arg Lys Arg Arg Arg Met Ser Gln Phe Asp Ile Leu Cys Lys 
        595                 600                 605             


Thr Pro Pro Lys Val Leu Val Arg Gln Phe Val Glu Arg Phe Glu Arg 
    610                 615                 620                 


Pro Ser Gly Glu Lys Ile Ala Ser Cys Ala Ala Glu Leu Thr Tyr Leu 
625                 630                 635                 640 


Cys Trp Met Ile Thr His Asn Gly Thr Ala Ile Lys Arg Ala Thr Phe 
                645                 650                 655     


Met Ser Tyr Asn Thr Ile Ile Ser Asn Ser Leu Ser Phe Asp Ile Val 
            660                 665                 670         


Asn Lys Ser Leu Gln Phe Lys Tyr Lys Thr Gln Lys Ala Thr Ile Leu 
        675                 680                 685             


Glu Ala Ser Leu Lys Lys Leu Ile Pro Ala Trp Glu Phe Thr Ile Ile 
    690                 695                 700                 


Pro Tyr Asn Gly Gln Lys His Gln Ser Asp Ile Thr Asp Ile Val Ser 
705                 710                 715                 720 


Ser Leu Gln Leu Gln Phe Glu Ser Ser Glu Glu Ala Asp Lys Gly Asn 
                725                 730                 735     


Ser His Ser Lys Lys Met Leu Lys Ala Leu Leu Ser Glu Gly Glu Ser 
            740                 745                 750         


Ile Trp Glu Ile Thr Glu Lys Ile Leu Asn Ser Phe Glu Tyr Thr Ser 
        755                 760                 765             


Arg Phe Thr Lys Thr Lys Thr Leu Tyr Gln Phe Leu Phe Leu Ala Thr 
    770                 775                 780                 


Phe Ile Asn Cys Gly Arg Phe Ser Asp Ile Lys Asn Val Asp Pro Lys 
785                 790                 795                 800 


Ser Phe Lys Leu Val Gln Asn Lys Tyr Leu Gly Val Ile Ile Gln Cys 
                805                 810                 815     


Leu Val Thr Glu Thr Lys Thr Ser Val Ser Arg His Ile Tyr Phe Phe 
            820                 825                 830         


Ser Ala Arg Gly Arg Ile Asp Pro Leu Val Tyr Leu Asp Glu Phe Leu 
        835                 840                 845             


Arg Asn Ser Glu Pro Val Leu Lys Arg Val Asn Arg Thr Gly Asn Ser 
    850                 855                 860                 


Ser Ser Asn Lys Gln Glu Tyr Gln Leu Leu Lys Asp Asn Leu Val Arg 
865                 870                 875                 880 


Ser Tyr Asn Lys Ala Leu Lys Lys Asn Ala Pro Tyr Pro Ile Phe Ala 
                885                 890                 895     


Ile Lys Asn Gly Pro Lys Ser His Ile Gly Arg His Leu Met Thr Ser 
            900                 905                 910         


Phe Leu Ser Met Lys Gly Leu Thr Glu Leu Thr Asn Val Val Gly Asn 
        915                 920                 925             


Trp Ser Asp Lys Arg Ala Ser Ala Val Ala Arg Thr Thr Tyr Thr His 
    930                 935                 940                 


Gln Ile Thr Ala Ile Pro Asp His Tyr Phe Ala Leu Val Ser Arg Tyr 
945                 950                 955                 960 


Tyr Ala Tyr Asp Pro Ile Ser Lys Glu Met Ile Ala Leu Lys Asp Glu 
                965                 970                 975     


Thr Asn Pro Ile Glu Glu Trp Gln His Ile Glu Gln Leu Lys Gly Ser 
            980                 985                 990         


Ala Glu Gly Ser Ile Arg Tyr Pro  Ala Trp Asn Gly Ile  Ile Ser Gln 
        995                 1000                 1005             


Glu Val  Leu Asp Tyr Leu Ser  Ser Tyr Ile Asn Arg  Arg Ile Gly 
    1010                 1015                 1020             


Pro Val  Glu Gln Lys Leu Ile  Ser Glu Glu Asp Leu  
    1025                 1030                 1035 


<210>  159
<211>  950
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  159

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro 
        275                 280                 285             


Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
    290                 295                 300                 


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
305                 310                 315                 320 


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
                325                 330                 335     


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
            340                 345                 350         


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
        355                 360                 365             


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
    370                 375                 380                 


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
385                 390                 395                 400 


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
                405                 410                 415     


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
            420                 425                 430         


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
        435                 440                 445             


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
    450                 455                 460                 


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
465                 470                 475                 480 


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
                485                 490                 495     


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
            500                 505                 510         


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
        515                 520                 525             


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
    530                 535                 540                 


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
545                 550                 555                 560 


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
                565                 570                 575     


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
            580                 585                 590         


Leu Ser Arg Lys Arg Arg Arg Met Val Pro Lys Lys Lys Arg Lys Val 
        595                 600                 605             


Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu Pro Val Asp 
    610                 615                 620                 


Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met Phe Arg Asp 
625                 630                 635                 640 


Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu Ser Val Cys 
                645                 650                 655     


Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys Trp Phe Pro 
            660                 665                 670         


Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu Gln Ala Arg 
        675                 680                 685             


Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln Leu Asn Met 
    690                 695                 700                 


Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser Asn Ala Val 
705                 710                 715                 720 


Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp Ala Gly Glu 
                725                 730                 735     


Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe Asp Gln Val 
            740                 745                 750         


Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile Arg Asn Leu 
        755                 760                 765             


Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile Ala Glu Ile 
    770                 775                 780                 


Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly Gly Arg Met 
785                 790                 795                 800 


Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr Ala Gly Val 
                805                 810                 815     


Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu Arg Trp Ile 
            820                 825                 830         


Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu Phe Cys Arg 
        835                 840                 845             


Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser Gln Leu Ser 
    850                 855                 860                 


Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg Leu Ile Tyr 
865                 870                 875                 880 


Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp Ser Gly His 
                885                 890                 895     


Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala Gly Val Ser 
            900                 905                 910         


Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val Asn Ile Val 
        915                 920                 925             


Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala Met Val Arg 
    930                 935                 940                 


Leu Leu Glu Asp Gly Asp 
945                 950 


<210>  160
<211>  1173
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  160

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro 
        275                 280                 285             


Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
    290                 295                 300                 


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
305                 310                 315                 320 


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
                325                 330                 335     


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
            340                 345                 350         


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
        355                 360                 365             


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
    370                 375                 380                 


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
385                 390                 395                 400 


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
                405                 410                 415     


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
            420                 425                 430         


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
        435                 440                 445             


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
    450                 455                 460                 


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
465                 470                 475                 480 


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
                485                 490                 495     


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
            500                 505                 510         


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
        515                 520                 525             


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
    530                 535                 540                 


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
545                 550                 555                 560 


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
                565                 570                 575     


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
            580                 585                 590         


Leu Ser Arg Lys Arg Arg Arg Met Glu Leu Leu Ser Pro Pro Leu Arg 
        595                 600                 605             


Asp Ile Asp Leu Thr Gly Pro Asp Gly Ser Leu Cys Ser Phe Glu Thr 
    610                 615                 620                 


Ala Asp Asp Phe Tyr Asp Asp Pro Cys Phe Asp Ser Pro Asp Leu Arg 
625                 630                 635                 640 


Phe Phe Glu Asp Leu Asp Pro Arg Leu Val His Met Gly Ala Leu Leu 
                645                 650                 655     


Lys Pro Glu Glu His Ala His Phe Pro Thr Ala Val His Pro Gly Pro 
            660                 665                 670         


Gly Ala Arg Glu Asp Glu His Val Arg Ala Pro Ser Gly His His Gln 
        675                 680                 685             


Ala Gly Arg Cys Leu Leu Trp Ala Cys Lys Ala Cys Lys Arg Lys Thr 
    690                 695                 700                 


Thr Asn Ala Asp Arg Arg Lys Ala Ala Thr Met Arg Glu Arg Arg Arg 
705                 710                 715                 720 


Leu Ser Lys Val Asn Glu Ala Phe Glu Thr Leu Lys Arg Cys Thr Ser 
                725                 730                 735     


Ser Asn Pro Asn Gln Arg Leu Pro Lys Val Glu Ile Leu Arg Asn Ala 
            740                 745                 750         


Ile Arg Tyr Ile Glu Gly Leu Gln Ala Leu Leu Arg Asp Gln Asp Ala 
        755                 760                 765             


Ala Pro Pro Gly Ala Ala Ala Phe Tyr Ala Pro Gly Pro Leu Pro Pro 
    770                 775                 780                 


Gly Arg Gly Ser Glu His Tyr Ser Gly Asp Ser Asp Ala Ser Ser Pro 
785                 790                 795                 800 


Arg Ser Asn Cys Ser Asp Gly Met Met Asp Tyr Ser Gly Pro Pro Ser 
                805                 810                 815     


Gly Pro Arg Arg Gln Asn Gly Tyr Asp Thr Ala Tyr Tyr Ser Glu Ala 
            820                 825                 830         


Ala Arg Glu Ser Arg Pro Gly Lys Ser Ala Ala Val Ser Ser Leu Asp 
        835                 840                 845             


Cys Leu Ser Ser Ile Val Glu Arg Ile Ser Thr Asp Ser Pro Ala Ala 
    850                 855                 860                 


Pro Ala Leu Leu Leu Ala Asp Ala Pro Pro Glu Ser Pro Pro Gly Pro 
865                 870                 875                 880 


Pro Glu Gly Ala Ser Leu Ser Asp Thr Glu Gln Gly Thr Gln Thr Pro 
                885                 890                 895     


Ser Pro Asp Ala Ala Pro Gln Cys Pro Ala Gly Ser Asn Pro Asn Ala 
            900                 905                 910         


Ile Tyr Gln Val Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        915                 920                 925             


Ser Met Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn Met His Met 
    930                 935                 940                 


Lys Leu Tyr Met Glu Gly Thr Val Asn Asn His His Phe Lys Cys Thr 
945                 950                 955                 960 


Ser Glu Gly Glu Gly Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile 
                965                 970                 975     


Lys Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala 
            980                 985                 990         


Thr Ser Phe Met Tyr Gly Ser Arg  Thr Phe Ile Asn His  Thr Gln Gly 
        995                 1000                 1005             


Ile Pro  Asp Phe Phe Lys Gln  Ser Phe Pro Glu Gly  Phe Thr Trp 
    1010                 1015                 1020             


Glu Arg  Val Thr Thr Tyr Glu  Asp Gly Gly Val Leu  Thr Ala Thr 
    1025                 1030                 1035             


Gln Asp  Thr Ser Leu Gln Asp  Gly Cys Leu Ile Tyr  Asn Val Lys 
    1040                 1045                 1050             


Ile Arg  Gly Val Asn Phe Pro  Ser Asn Gly Pro Val  Met Gln Lys 
    1055                 1060                 1065             


Lys Thr  Leu Gly Trp Glu Ala  Asn Thr Glu Met Leu  Tyr Pro Ala 
    1070                 1075                 1080             


Asp Gly  Gly Leu Glu Gly Arg  Thr Asp Met Ala Leu  Lys Leu Val 
    1085                 1090                 1095             


Gly Gly  Gly His Leu Ile Cys  Asn Phe Lys Thr Thr  Tyr Arg Ser 
    1100                 1105                 1110             


Lys Lys  Pro Ala Lys Asn Leu  Lys Met Pro Gly Val  Tyr Tyr Val 
    1115                 1120                 1125             


Asp His  Arg Leu Glu Arg Ile  Lys Glu Ala Asp Lys  Glu Thr Tyr 
    1130                 1135                 1140             


Val Glu  Gln His Glu Val Ala  Val Ala Arg Tyr Cys  Asp Leu Pro 
    1145                 1150                 1155             


Ser Lys  Leu Gly His Lys Leu  Asn Gly Met Asp Glu  Leu Tyr Lys 
    1160                 1165                 1170             


<210>  161
<211>  1134
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  161

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr Leu 
    50                  55                  60                  


Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu 
            100                 105                 110         


Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr Thr 
        115                 120                 125             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu Ser 
145                 150                 155                 160 


Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys Thr 
                165                 170                 175     


Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg Gln 
            180                 185                 190         


Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser Glu 
        195                 200                 205             


Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile Lys 
    210                 215                 220                 


Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr 
225                 230                 235                 240 


Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly Gly 
                245                 250                 255     


Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            260                 265                 270         


Ser Ile Leu Asp Tyr Ser Phe Thr Gly Gly Ala Gly Arg Asp Ile Pro 
        275                 280                 285             


Pro Pro Gln Ile Glu Glu Ala Cys Glu Leu Pro Glu Cys Gln Val Asp 
    290                 295                 300                 


Ala Gly Asn Lys Val Cys Asn Leu Gln Cys Asn Asn His Ala Cys Gly 
305                 310                 315                 320 


Trp Asp Gly Gly Asp Cys Ser Leu Asn Phe Asn Asp Pro Trp Lys Asn 
                325                 330                 335     


Cys Thr Gln Ser Leu Gln Cys Trp Lys Tyr Phe Ser Asp Gly His Cys 
            340                 345                 350         


Asp Ser Gln Cys Asn Ser Ala Gly Cys Leu Phe Asp Gly Phe Asp Cys 
        355                 360                 365             


Gln Leu Thr Glu Gly Gln Cys Asn Pro Leu Tyr Asp Gln Tyr Cys Lys 
    370                 375                 380                 


Asp His Phe Ser Asp Gly His Cys Asp Gln Gly Cys Asn Ser Ala Glu 
385                 390                 395                 400 


Cys Glu Trp Asp Gly Leu Asp Cys Ala Glu His Val Pro Glu Arg Leu 
                405                 410                 415     


Ala Ala Gly Thr Leu Val Leu Val Val Leu Leu Pro Pro Asp Gln Leu 
            420                 425                 430         


Arg Asn Asn Ser Phe His Phe Leu Arg Glu Leu Ser His Val Leu His 
        435                 440                 445             


Thr Asn Val Val Phe Lys Arg Asp Ala Gln Gly Gln Gln Met Ile Phe 
    450                 455                 460                 


Pro Tyr Tyr Gly His Glu Glu Glu Leu Arg Lys His Pro Ile Lys Arg 
465                 470                 475                 480 


Ser Thr Val Gly Trp Ala Thr Ser Ser Leu Leu Pro Gly Thr Ser Gly 
                485                 490                 495     


Gly Arg Gln Arg Arg Glu Leu Asp Pro Met Asp Ile Arg Gly Ser Ile 
            500                 505                 510         


Val Tyr Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Ser Ser Ser Gln 
        515                 520                 525             


Cys Phe Gln Ser Ala Thr Asp Val Ala Ala Phe Leu Gly Ala Leu Ala 
    530                 535                 540                 


Ser Leu Gly Ser Leu Asn Ile Pro Tyr Lys Ile Glu Ala Val Lys Ser 
545                 550                 555                 560 


Glu Pro Val Glu Pro Pro Leu Pro Ser Gln Leu His Leu Met Tyr Val 
                565                 570                 575     


Ala Ala Ala Ala Phe Val Leu Leu Phe Phe Val Gly Cys Gly Val Leu 
            580                 585                 590         


Leu Ser Arg Lys Arg Arg Arg Met Gly Ile Val Glu Pro Gly Cys Gly 
        595                 600                 605             


Asp Met Leu Thr Gly Thr Glu Pro Met Pro Gly Ser Asp Glu Gly Arg 
    610                 615                 620                 


Ala Pro Gly Ala Asp Pro Gln His Arg Tyr Phe Tyr Pro Glu Pro Gly 
625                 630                 635                 640 


Ala Gln Asp Ala Asp Glu Arg Arg Gly Gly Gly Ser Leu Gly Ser Pro 
                645                 650                 655     


Tyr Pro Gly Gly Ala Leu Val Pro Ala Pro Pro Ser Arg Phe Leu Gly 
            660                 665                 670         


Ala Tyr Ala Tyr Pro Pro Arg Pro Gln Ala Ala Gly Phe Pro Gly Ala 
        675                 680                 685             


Gly Glu Ser Phe Pro Pro Pro Ala Asp Ala Glu Gly Tyr Gln Pro Gly 
    690                 695                 700                 


Glu Gly Tyr Ala Ala Pro Asp Pro Arg Ala Gly Leu Tyr Pro Gly Pro 
705                 710                 715                 720 


Arg Glu Asp Tyr Ala Leu Pro Ala Gly Leu Glu Val Ser Gly Lys Leu 
                725                 730                 735     


Arg Val Ala Leu Asn Asn His Leu Leu Trp Ser Lys Phe Asn Gln His 
            740                 745                 750         


Gln Thr Glu Met Ile Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe 
        755                 760                 765             


Leu Ser Phe Thr Val Ala Gly Leu Glu Pro Thr Ser His Tyr Arg Met 
    770                 775                 780                 


Phe Val Asp Val Val Leu Val Asp Gln His His Trp Arg Tyr Gln Ser 
785                 790                 795                 800 


Gly Lys Trp Val Gln Cys Gly Lys Ala Glu Gly Ser Met Pro Gly Asn 
                805                 810                 815     


Arg Leu Tyr Val His Pro Asp Ser Pro Asn Thr Gly Ala His Trp Met 
            820                 825                 830         


Arg Gln Glu Val Ser Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly 
        835                 840                 845             


Ala Ser Asn Asn Val Thr Gln Met Ile Val Leu Gln Ser Leu His Lys 
    850                 855                 860                 


Tyr Gln Pro Arg Leu His Ile Val Glu Val Asn Asp Gly Glu Pro Glu 
865                 870                 875                 880 


Ala Ala Cys Asn Ala Ser Asn Thr His Ile Phe Thr Phe Gln Glu Thr 
                885                 890                 895     


Gln Phe Ile Ala Val Thr Ala Tyr Gln Asn Ala Glu Ile Thr Gln Leu 
            900                 905                 910         


Lys Ile Asp Asn Asn Pro Phe Ala Lys Gly Phe Arg Glu Asn Phe Glu 
        915                 920                 925             


Ser Met Tyr Thr Ser Val Asp Thr Ser Ile Pro Ser Pro Pro Gly Pro 
    930                 935                 940                 


Asn Cys Gln Phe Leu Gly Gly Asp His Tyr Ser Pro Leu Leu Pro Asn 
945                 950                 955                 960 


Gln Tyr Pro Val Pro Ser Arg Phe Tyr Pro Asp Leu Pro Gly Gln Ala 
                965                 970                 975     


Lys Asp Val Val Pro Gln Ala Tyr Trp Leu Gly Ala Pro Arg Asp His 
            980                 985                 990         


Ser Tyr Glu Ala Glu Phe Arg Ala  Val Ser Met Lys Pro  Ala Phe Leu 
        995                 1000                 1005             


Pro Ser  Ala Pro Gly Pro Thr  Met Ser Tyr Tyr Arg  Gly Gln Glu 
    1010                 1015                 1020             


Val Leu  Ala Pro Gly Ala Gly  Trp Pro Val Ala Pro  Gln Tyr Pro 
    1025                 1030                 1035             


Pro Lys  Met Gly Pro Ala Ser  Trp Phe Arg Pro Met  Arg Thr Leu 
    1040                 1045                 1050             


Pro Met  Glu Pro Gly Pro Gly  Gly Ser Glu Gly Arg  Gly Pro Glu 
    1055                 1060                 1065             


Asp Gln  Gly Pro Pro Leu Val  Trp Thr Glu Ile Ala  Pro Ile Arg 
    1070                 1075                 1080             


Pro Glu  Ser Ser Asp Ser Gly  Leu Gly Glu Gly Asp  Ser Lys Arg 
    1085                 1090                 1095             


Arg Arg  Val Ser Pro Tyr Pro  Ser Ser Gly Asp Ser  Ser Ser Pro 
    1100                 1105                 1110             


Ala Gly  Ala Pro Ser Pro Phe  Asp Lys Glu Ala Glu  Gly Gln Phe 
    1115                 1120                 1125             


Tyr Asn  Tyr Phe Pro Asn 
    1130                 


<210>  162
<211>  701
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  162

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ile Pro Tyr 
385                 390                 395                 400 


Lys Ile Glu Ala Val Lys Ser Glu Pro Val Glu Pro Pro Leu Pro Ser 
                405                 410                 415     


Gln Leu His Leu Met Tyr Val Ala Ala Ala Ala Phe Val Leu Leu Phe 
            420                 425                 430         


Phe Val Gly Cys Gly Val Leu Leu Ser Arg Lys Arg Arg Arg Gln Leu 
        435                 440                 445             


Cys Ile Gln Lys Leu Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn 
    450                 455                 460                 


Ser Ala Leu Glu Leu Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr 
465                 470                 475                 480 


Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp 
                485                 490                 495     


His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met 
            500                 505                 510         


Leu Asp Arg His His Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp 
        515                 520                 525             


Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu 
    530                 535                 540                 


Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu 
545                 550                 555                 560 


Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln 
                565                 570                 575     


Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His 
            580                 585                 590         


Phe Thr Leu Gly Cys Val Leu Glu Asp Gln Glu His Gln Val Ala Lys 
        595                 600                 605             


Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg 
    610                 615                 620                 


Gln Ala Ile Glu Leu Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu 
625                 630                 635                 640 


Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys 
                645                 650                 655     


Glu Ser Gly Gly Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
            660                 665                 670         


Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala 
        675                 680                 685             


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly 
    690                 695                 700     


<210>  163
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  163

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Leu 
            20                  25                  30          


Lys Gly Leu Gly Asn Thr Asp Arg His Gly Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Ala Asp 
    130                 135                 140                 


Ser Thr Asp Lys Val Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Arg Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Thr Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro Tyr Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Asp Ile Leu Lys Glu Tyr Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Val Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Arg Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asp Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Arg Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  164
<211>  560
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Ala Gly Pro Gln Pro Leu Ala Leu Gln Leu Glu Gln Leu Leu Asn 
1               5                   10                  15      


Pro Arg Pro Ser Glu Ala Asp Pro Glu Ala Asp Pro Glu Glu Ala Thr 
            20                  25                  30          


Ala Ala Arg Val Ile Asp Arg Phe Asp Glu Gly Glu Asp Gly Glu Gly 
        35                  40                  45              


Asp Phe Leu Val Val Gly Ser Ile Arg Lys Leu Ala Ser Ala Ser Leu 
    50                  55                  60                  


Leu Asp Thr Asp Lys Arg Tyr Cys Gly Lys Thr Thr Ser Arg Lys Ala 
65                  70                  75                  80  


Trp Asn Glu Asp His Trp Glu Gln Thr Leu Pro Gly Ser Ser Asp Glu 
                85                  90                  95      


Glu Ile Ser Asp Glu Glu Gly Ser Gly Asp Glu Asp Ser Glu Gly Leu 
            100                 105                 110         


Gly Leu Glu Glu Tyr Asp Glu Asp Asp Leu Gly Ala Ala Glu Glu Gln 
        115                 120                 125             


Glu Cys Gly Asp His Arg Glu Ser Lys Lys Ser Arg Ser His Ser Ala 
    130                 135                 140                 


Lys Thr Pro Gly Phe Ser Val Gln Ser Ile Ser Asp Phe Glu Lys Phe 
145                 150                 155                 160 


Thr Lys Gly Met Asp Asp Leu Gly Ser Ser Glu Glu Glu Glu Asp Glu 
                165                 170                 175     


Glu Ser Gly Met Glu Glu Gly Asp Asp Ala Glu Asp Ser Gln Gly Glu 
            180                 185                 190         


Ser Glu Glu Asp Arg Ala Gly Asp Arg Asn Ser Glu Asp Asp Gly Val 
        195                 200                 205             


Val Met Thr Phe Ser Ser Val Lys Val Ser Glu Glu Val Glu Lys Gly 
    210                 215                 220                 


Arg Ala Val Lys Asn Gln Ile Ala Leu Trp Asp Gln Leu Leu Glu Gly 
225                 230                 235                 240 


Arg Ile Lys Leu Gln Lys Ala Leu Leu Thr Thr Asn Gln Leu Pro Gln 
                245                 250                 255     


Pro Asp Val Phe Pro Leu Phe Lys Asp Lys Gly Gly Pro Glu Phe Ser 
            260                 265                 270         


Ser Ala Leu Lys Asn Ser His Lys Ala Leu Lys Ala Leu Leu Arg Ser 
        275                 280                 285             


Leu Val Gly Leu Gln Glu Glu Leu Leu Phe Gln Tyr Pro Asp Thr Arg 
    290                 295                 300                 


Tyr Leu Val Asp Gly Thr Lys Pro Asn Ala Gly Ser Glu Glu Ile Ser 
305                 310                 315                 320 


Ser Glu Asp Asp Glu Leu Val Glu Glu Lys Lys Gln Gln Arg Arg Arg 
                325                 330                 335     


Val Pro Ala Lys Arg Lys Leu Glu Met Glu Asp Tyr Pro Ser Phe Met 
            340                 345                 350         


Ala Lys Arg Phe Ala Asp Phe Thr Val Tyr Arg Asn Arg Thr Leu Gln 
        355                 360                 365             


Lys Trp His Asp Lys Thr Lys Leu Ala Ser Gly Lys Leu Gly Lys Gly 
    370                 375                 380                 


Phe Gly Ala Phe Glu Arg Ser Ile Leu Thr Gln Ile Asp His Ile Leu 
385                 390                 395                 400 


Met Asp Lys Glu Arg Leu Leu Arg Arg Thr Gln Thr Lys Arg Ser Val 
                405                 410                 415     


Tyr Arg Val Leu Gly Lys Pro Glu Pro Ala Ala Gln Pro Val Pro Glu 
            420                 425                 430         


Ser Leu Pro Gly Glu Pro Glu Ile Leu Pro Gln Ala Pro Ala Asn Ala 
        435                 440                 445             


His Leu Lys Asp Leu Asp Glu Glu Ile Phe Asp Asp Asp Asp Phe Tyr 
    450                 455                 460                 


His Gln Leu Leu Arg Glu Leu Ile Glu Arg Lys Thr Ser Ser Leu Asp 
465                 470                 475                 480 


Pro Asn Asp Gln Val Ala Met Gly Arg Gln Trp Leu Ala Ile Gln Lys 
                485                 490                 495     


Leu Arg Ser Lys Ile His Lys Lys Val Asp Arg Lys Ala Ser Lys Gly 
            500                 505                 510         


Arg Lys Leu Arg Phe His Val Leu Ser Lys Leu Leu Ser Phe Met Ala 
        515                 520                 525             


Pro Ile Asp His Thr Thr Met Asn Asp Asp Ala Arg Thr Glu Leu Tyr 
    530                 535                 540                 


Arg Ser Leu Phe Gly Gln Leu His Pro Pro Asp Glu Gly His Gly Asp 
545                 550                 555                 560 


<210>  165
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Glu Ala Glu Glu Ser Glu Lys Ala Ala Thr Glu Gln Glu Pro Leu 
1               5                   10                  15      


Glu Gly Thr Glu Gln Thr Leu Asp Ala Glu Glu Glu Gln Glu Glu Ser 
            20                  25                  30          


Glu Glu Ala Ala Cys Gly Ser Lys Lys Arg Val Val Pro Gly Ile Val 
        35                  40                  45              


Tyr Leu Gly His Ile Pro Pro Arg Phe Arg Pro Leu His Val Arg Asn 
    50                  55                  60                  


Leu Leu Ser Ala Tyr Gly Glu Val Gly Arg Val Phe Phe Gln Ala Glu 
65                  70                  75                  80  


Asp Arg Phe Val Arg Arg Lys Lys Lys Ala Ala Ala Ala Ala Gly Gly 
                85                  90                  95      


Lys Lys Arg Ser Tyr Thr Lys Asp Tyr Thr Glu Gly Trp Val Glu Phe 
            100                 105                 110         


Arg Asp Lys Arg Ile Ala Lys Arg Val Ala Ala Ser Leu His Asn Thr 
        115                 120                 125             


Pro Met Gly Ala Arg Arg Arg Ser Pro Phe Arg Tyr Asp Leu Trp Asn 
    130                 135                 140                 


Leu Lys Tyr Leu His Arg Phe Thr Trp Ser His Leu Ser Glu His Leu 
145                 150                 155                 160 


Ala Phe Glu Arg Gln Val Arg Arg Gln Arg Leu Arg Ala Glu Val Ala 
                165                 170                 175     


Gln Ala Lys Arg Glu Thr Asp Phe Tyr Leu Gln Ser Val Glu Arg Gly 
            180                 185                 190         


Gln Arg Phe Leu Ala Ala Asp Gly Asp Pro Ala Arg Pro Asp Gly Ser 
        195                 200                 205             


Trp Thr Phe Ala Gln Arg Pro Thr Glu Gln Glu Leu Arg Ala Arg Lys 
    210                 215                 220                 


Ala Ala Arg Pro Gly Gly Arg Glu Arg Ala Arg Leu Ala Thr Ala Gln 
225                 230                 235                 240 


Asp Lys Ala Arg Ser Asn Lys Gly Leu Leu Ala Arg Ile Phe Gly Ala 
                245                 250                 255     


Pro Pro Pro Ser Glu Ser Met Glu Gly Pro Ser Leu Val Arg Asp Ser 
            260                 265                 270         


<210>  166
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Ala Ala Ala Ile Thr Asp Met Ala Asp Leu Glu Glu Leu Ser Arg 
1               5                   10                  15      


Leu Ser Pro Leu Pro Pro Gly Ser Pro Gly Ser Ala Ala Arg Gly Arg 
            20                  25                  30          


Ala Glu Pro Pro Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        35                  40                  45              


Ala Glu Ala Glu Ala Val Ala Ala Leu Leu Leu Asn Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Val Gly Gly Gly Glu Ala Glu 
65                  70                  75                  80  


Thr Met Ser Glu Pro Ser Pro Glu Ser Ala Ser Gln Ala Gly Glu Asp 
                85                  90                  95      


Glu Asp Glu Glu Glu Asp Asp Glu Glu Glu Glu Asp Glu Ser Ser Ser 
            100                 105                 110         


Ser Gly Gly Gly Glu Glu Glu Ser Ser Ala Glu Ser Leu Val Gly Ser 
        115                 120                 125             


Ser Gly Gly Ser Ser Ser Asp Glu Thr Arg Ser Leu Ser Pro Gly Ala 
    130                 135                 140                 


Ala Ser Ser Ser Ser Gly Asp Gly Asp Gly Lys Glu Gly Leu Glu Glu 
145                 150                 155                 160 


Pro Lys Gly Pro Arg Gly Ser Gln Gly Gly Gly Gly Gly Gly Ser Ser 
                165                 170                 175     


Ser Ser Ser Val Val Ser Ser Gly Gly Asp Glu Gly Tyr Gly Thr Gly 
            180                 185                 190         


Gly Gly Gly Ser Ser Ala Thr Ser Gly Gly Arg Arg Gly Ser Leu Glu 
        195                 200                 205             


Met Ser Ser Asp Gly Glu Pro Leu Ser Arg Met Asp Ser Glu Asp Ser 
    210                 215                 220                 


Ile Ser Ser Thr Ile Met Asp Val Asp Ser Thr Ile Ser Ser Gly Arg 
225                 230                 235                 240 


Ser Thr Pro Ala Met Met Asn Gly Gln Gly Ser Thr Thr Ser Ser Ser 
                245                 250                 255     


Lys Asn Ile Ala Tyr Asn Cys Cys Trp Asp Gln Cys Gln Ala Cys Phe 
            260                 265                 270         


Asn Ser Ser Pro Asp Leu Ala Asp His Ile Arg Ser Ile His Val Asp 
        275                 280                 285             


Gly Gln Arg Gly Gly Val Phe Val Cys Leu Trp Lys Gly Cys Lys Val 
    290                 295                 300                 


Tyr Asn Thr Pro Ser Thr Ser Gln Ser Trp Leu Gln Arg His Met Leu 
305                 310                 315                 320 


Thr His Ser Gly Asp Lys Pro Phe Lys Cys Val Val Gly Gly Cys Asn 
                325                 330                 335     


Ala Ser Phe Ala Ser Gln Gly Gly Leu Ala Arg His Val Pro Thr His 
            340                 345                 350         


Phe Ser Gln Gln Asn Ser Ser Lys Val Ser Ser Gln Pro Lys Ala Lys 
        355                 360                 365             


Glu Glu Ser Pro Ser Lys Ala Gly Met Asn Lys Arg Arg Lys Leu Lys 
    370                 375                 380                 


Asn Lys Arg Arg Arg Ser Leu Pro Arg Pro His Asp Phe Phe Asp Ala 
385                 390                 395                 400 


Gln Thr Leu Asp Ala Ile Arg His Arg Ala Ile Cys Phe Asn Leu Ser 
                405                 410                 415     


Ala His Ile Glu Ser Leu Gly Lys Gly His Ser Val Val Phe His Ser 
            420                 425                 430         


Thr Val Ile Ala Lys Arg Lys Glu Asp Ser Gly Lys Ile Lys Leu Leu 
        435                 440                 445             


Leu His Trp Met Pro Glu Asp Ile Leu Pro Asp Val Trp Val Asn Glu 
    450                 455                 460                 


Ser Glu Arg His Gln Leu Lys Thr Lys Val Val His Leu Ser Lys Leu 
465                 470                 475                 480 


Pro Lys Asp Thr Ala Leu Leu Leu Asp Pro Asn Ile Tyr Arg Thr Met 
                485                 490                 495     


Pro Gln Lys Arg Leu Lys Arg Thr Leu Ile Arg Lys Val Phe Asn Leu 
            500                 505                 510         


Tyr Leu Ser Lys Gln 
        515         


<210>  167
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Glu Asp Ser His Lys Ser Thr Thr Ser Glu Thr Ala Pro Gln Pro 
1               5                   10                  15      


Gly Ser Ala Val Gln Gly Ala His Ile Ser His Ile Ala Gln Gln Val 
            20                  25                  30          


Ser Ser Leu Ser Glu Ser Glu Glu Ser Gln Asp Ser Ser Asp Ser Ile 
        35                  40                  45              


Gly Ser Ser Gln Lys Ala His Gly Ile Leu Ala Arg Arg Pro Ser Tyr 
    50                  55                  60                  


Arg Lys Ile Leu Lys Asp Leu Ser Ser Glu Asp Thr Arg Gly Arg Lys 
65                  70                  75                  80  


Gly Asp Gly Glu Asn Ser Gly Val Ser Ala Ala Val Thr Ser Met Ser 
                85                  90                  95      


Val Pro Thr Pro Ile Tyr Gln Thr Ser Ser Gly Gln Tyr Ile Ala Ile 
            100                 105                 110         


Ala Pro Asn Gly Ala Leu Gln Leu Ala Ser Pro Gly Thr Asp Gly Val 
        115                 120                 125             


Gln Gly Leu Gln Thr Leu Thr Met Thr Asn Ser Gly Ser Thr Gln Gln 
    130                 135                 140                 


Gly Thr Thr Ile Leu Gln Tyr Ala Gln Thr Ser Asp Gly Gln Gln Ile 
145                 150                 155                 160 


Leu Val Pro Ser Asn Gln Val Val Val Gln Thr Ala Ser Gly Asp Met 
                165                 170                 175     


Gln Thr Tyr Gln Ile Arg Thr Thr Pro Ser Ala Thr Ser Leu Pro Gln 
            180                 185                 190         


Thr Val Val Met Thr Ser Pro Val Thr Leu Thr Ser Gln Thr Thr Lys 
        195                 200                 205             


Thr Asp Asp Pro Gln Leu Lys Arg Glu Ile Arg Leu Met Lys Asn Arg 
    210                 215                 220                 


Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys 
225                 230                 235                 240 


Leu Glu Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile 
                245                 250                 255     


Glu Glu Leu Lys Thr Leu Lys Asp Leu Tyr Ser Asn Lys Ser Val 
            260                 265                 270     


<210>  168
<211>  736
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Ser Leu Ser Glu Asn Ser Val Phe Ala Tyr Glu Ser Ser Val His 
1               5                   10                  15      


Ser Thr Asn Val Leu Leu Ser Leu Asn Asp Gln Arg Lys Lys Asp Val 
            20                  25                  30          


Leu Cys Asp Val Thr Ile Phe Val Glu Gly Gln Arg Phe Arg Ala His 
        35                  40                  45              


Arg Ser Val Leu Ala Ala Cys Ser Ser Tyr Phe His Ser Arg Ile Val 
    50                  55                  60                  


Gly Gln Ala Asp Gly Glu Leu Asn Ile Thr Leu Pro Glu Glu Val Thr 
65                  70                  75                  80  


Val Lys Gly Phe Glu Pro Leu Ile Gln Phe Ala Tyr Thr Ala Lys Leu 
                85                  90                  95      


Ile Leu Ser Lys Glu Asn Val Asp Glu Val Cys Lys Cys Val Glu Phe 
            100                 105                 110         


Leu Ser Val His Asn Ile Glu Glu Ser Cys Phe Gln Phe Leu Lys Phe 
        115                 120                 125             


Lys Phe Leu Asp Ser Thr Ala Asp Gln Gln Glu Cys Pro Arg Lys Lys 
    130                 135                 140                 


Cys Phe Ser Ser His Cys Gln Lys Thr Asp Leu Lys Leu Ser Leu Leu 
145                 150                 155                 160 


Asp Gln Arg Asp Leu Glu Thr Asp Glu Val Glu Glu Phe Leu Glu Asn 
                165                 170                 175     


Lys Asn Val Gln Thr Pro Gln Cys Lys Leu Arg Arg Tyr Gln Gly Asn 
            180                 185                 190         


Ala Lys Ala Ser Pro Pro Leu Gln Asp Ser Ala Ser Gln Thr Tyr Glu 
        195                 200                 205             


Ser Met Cys Leu Glu Lys Asp Ala Ala Leu Ala Leu Pro Ser Leu Cys 
    210                 215                 220                 


Pro Lys Tyr Arg Lys Phe Gln Lys Ala Phe Gly Thr Asp Arg Val Arg 
225                 230                 235                 240 


Thr Gly Glu Ser Ser Val Lys Asp Ile His Ala Ser Val Gln Pro Asn 
                245                 250                 255     


Glu Arg Ser Glu Asn Glu Cys Leu Gly Gly Val Pro Glu Cys Arg Asp 
            260                 265                 270         


Leu Gln Val Met Leu Lys Cys Asp Glu Ser Lys Leu Ala Met Glu Pro 
        275                 280                 285             


Glu Glu Thr Lys Lys Asp Pro Ala Ser Gln Cys Pro Thr Glu Lys Ser 
    290                 295                 300                 


Glu Val Thr Pro Phe Pro His Asn Ser Ser Ile Asp Pro His Gly Leu 
305                 310                 315                 320 


Tyr Ser Leu Ser Leu Leu His Thr Tyr Asp Gln Tyr Gly Asp Leu Asn 
                325                 330                 335     


Phe Ala Gly Met Gln Asn Thr Thr Val Leu Thr Glu Lys Pro Leu Ser 
            340                 345                 350         


Gly Thr Asp Val Gln Glu Lys Thr Phe Gly Glu Ser Gln Asp Leu Pro 
        355                 360                 365             


Leu Lys Ser Asp Leu Gly Thr Arg Glu Asp Ser Ser Val Ala Ser Ser 
    370                 375                 380                 


Asp Arg Ser Ser Val Glu Arg Glu Val Ala Glu His Leu Ala Lys Gly 
385                 390                 395                 400 


Phe Trp Ser Asp Ile Cys Ser Thr Asp Thr Pro Cys Gln Met Gln Leu 
                405                 410                 415     


Ser Pro Ala Val Ala Lys Asp Gly Ser Glu Gln Ile Ser Gln Lys Arg 
            420                 425                 430         


Ser Glu Cys Pro Trp Leu Gly Ile Arg Ile Ser Glu Ser Pro Glu Pro 
        435                 440                 445             


Gly Gln Arg Thr Phe Thr Thr Leu Ser Ser Val Asn Cys Pro Phe Ile 
    450                 455                 460                 


Ser Thr Leu Ser Thr Glu Gly Cys Ser Ser Asn Leu Glu Ile Gly Asn 
465                 470                 475                 480 


Asp Asp Tyr Val Ser Glu Pro Gln Gln Glu Pro Cys Pro Tyr Ala Cys 
                485                 490                 495     


Val Ile Ser Leu Gly Asp Asp Ser Glu Thr Asp Thr Glu Gly Asp Ser 
            500                 505                 510         


Glu Ser Cys Ser Ala Arg Glu Gln Glu Cys Glu Val Lys Leu Pro Phe 
        515                 520                 525             


Asn Ala Gln Arg Ile Ile Ser Leu Ser Arg Asn Asp Phe Gln Ser Leu 
    530                 535                 540                 


Leu Lys Met His Lys Leu Thr Pro Glu Gln Leu Asp Cys Ile His Asp 
545                 550                 555                 560 


Ile Arg Arg Arg Ser Lys Asn Arg Ile Ala Ala Gln Arg Cys Arg Lys 
                565                 570                 575     


Arg Lys Leu Asp Cys Ile Gln Asn Leu Glu Ser Glu Ile Glu Lys Leu 
            580                 585                 590         


Gln Ser Glu Lys Glu Ser Leu Leu Lys Glu Arg Asp His Ile Leu Ser 
        595                 600                 605             


Thr Leu Gly Glu Thr Lys Gln Asn Leu Thr Gly Leu Cys Gln Lys Val 
    610                 615                 620                 


Cys Lys Glu Ala Ala Leu Ser Gln Glu Gln Ile Gln Ile Leu Ala Lys 
625                 630                 635                 640 


Tyr Ser Ala Ala Asp Cys Pro Leu Ser Phe Leu Ile Ser Glu Lys Asp 
                645                 650                 655     


Lys Ser Thr Pro Asp Gly Glu Leu Ala Leu Pro Ser Ile Phe Ser Leu 
            660                 665                 670         


Ser Asp Arg Pro Pro Ala Val Leu Pro Pro Cys Ala Arg Gly Asn Ser 
        675                 680                 685             


Glu Pro Gly Tyr Ala Arg Gly Gln Glu Ser Gln Gln Met Ser Thr Ala 
    690                 695                 700                 


Thr Ser Glu Gln Ala Gly Pro Ala Glu Gln Cys Arg Gln Ser Gly Gly 
705                 710                 715                 720 


Ile Ser Asp Phe Cys Gln Gln Met Thr Asp Lys Cys Thr Thr Asp Glu 
                725                 730                 735     


<210>  169
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Asp Glu Gly Ile Pro His Leu Gln Glu Arg Gln Leu Leu Glu His 
1               5                   10                  15      


Arg Asp Phe Ile Gly Leu Asp Tyr Ser Ser Leu Tyr Met Cys Lys Pro 
            20                  25                  30          


Lys Arg Ser Met Lys Arg Asp Asp Thr Lys Asp Thr Tyr Lys Leu Pro 
        35                  40                  45              


His Arg Leu Ile Glu Lys Lys Arg Arg Asp Arg Ile Asn Glu Cys Ile 
    50                  55                  60                  


Ala Gln Leu Lys Asp Leu Leu Pro Glu His Leu Lys Leu Thr Thr Leu 
65                  70                  75                  80  


Gly His Leu Glu Lys Ala Val Val Leu Glu Leu Thr Leu Lys His Leu 
                85                  90                  95      


Lys Ala Leu Thr Ala Leu Thr Glu Gln Gln His Gln Lys Ile Ile Ala 
            100                 105                 110         


Leu Gln Asn Gly Glu Arg Ser Leu Lys Ser Pro Ile Gln Ser Asp Leu 
        115                 120                 125             


Asp Ala Phe His Ser Gly Phe Gln Thr Cys Ala Lys Glu Val Leu Gln 
    130                 135                 140                 


Tyr Leu Ser Arg Phe Glu Ser Trp Thr Pro Arg Glu Pro Arg Cys Val 
145                 150                 155                 160 


Gln Leu Ile Asn His Leu His Ala Val Ala Thr Gln Phe Leu Pro Thr 
                165                 170                 175     


Pro Gln Leu Leu Thr Gln Gln Val Pro Leu Ser Lys Gly Thr Gly Ala 
            180                 185                 190         


Pro Ser Ala Ala Gly Ser Ala Ala Ala Pro Cys Leu Glu Arg Ala Gly 
        195                 200                 205             


Gln Lys Leu Glu Pro Leu Ala Tyr Cys Val Pro Val Ile Gln Arg Thr 
    210                 215                 220                 


Gln Pro Ser Ala Glu Leu Ala Ala Glu Asn Asp Thr Asp Thr Asp Ser 
225                 230                 235                 240 


Gly Tyr Gly Gly Glu Ala Glu Ala Arg Pro Asp Arg Glu Lys Gly Lys 
                245                 250                 255     


Gly Ala Gly Ala Ser Arg Val Thr Ile Lys Gln Glu Pro Pro Gly Glu 
            260                 265                 270         


Asp Ser Pro Ala Pro Lys Arg Met Lys Leu Asp Ser Arg Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Pro Gly Gly Gly Ala Ala Ala Ala Ala Ala Ala Leu 
    290                 295                 300                 


Leu Gly Pro Asp Pro Ala Ala Ala Ala Ala Leu Leu Arg Pro Asp Ala 
305                 310                 315                 320 


Ala Leu Leu Ser Ser Leu Val Ala Phe Gly Gly Gly Gly Gly Ala Pro 
                325                 330                 335     


Phe Pro Gln Pro Ala Ala Ala Ala Ala Pro Phe Cys Leu Pro Phe Cys 
            340                 345                 350         


Phe Leu Ser Pro Ser Ala Ala Ala Ala Tyr Val Gln Pro Phe Leu Asp 
        355                 360                 365             


Lys Ser Gly Leu Glu Lys Tyr Leu Tyr Pro Ala Ala Ala Ala Ala Pro 
    370                 375                 380                 


Phe Pro Leu Leu Tyr Pro Gly Ile Pro Ala Pro Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Phe Pro Cys Leu Ser 
                405                 410                 415     


Ser Val Leu Ser Pro Pro Pro Glu Lys Ala Gly Ala Ala Ala Ala Thr 
            420                 425                 430         


Leu Leu Pro His Glu Val Ala Pro Leu Gly Ala Pro His Pro Gln His 
        435                 440                 445             


Pro His Gly Arg Thr His Leu Pro Phe Ala Gly Pro Arg Glu Pro Gly 
    450                 455                 460                 


Asn Pro Glu Ser Ser Ala Gln Glu Asp Pro Ser Gln Pro Gly Lys Glu 
465                 470                 475                 480 


Ala Pro 
        


<210>  170
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Leu Gln Asn Val Thr Pro His Asn Lys Leu Pro Gly Glu Gly Asn 
1               5                   10                  15      


Ala Gly Leu Leu Gly Leu Gly Pro Glu Ala Ala Ala Pro Gly Lys Arg 
            20                  25                  30          


Ile Arg Lys Pro Ser Leu Leu Tyr Glu Gly Phe Glu Ser Pro Thr Met 
        35                  40                  45              


Ala Ser Val Pro Ala Leu Gln Leu Thr Pro Ala Asn Pro Pro Pro Pro 
    50                  55                  60                  


Glu Val Ser Asn Pro Lys Lys Pro Gly Arg Val Thr Asn Gln Leu Gln 
65                  70                  75                  80  


Tyr Leu His Lys Val Val Met Lys Ala Leu Trp Lys His Gln Phe Ala 
                85                  90                  95      


Trp Pro Phe Arg Gln Pro Val Asp Ala Val Lys Leu Gly Leu Pro Asp 
            100                 105                 110         


Tyr His Lys Ile Ile Lys Gln Pro Met Asp Met Gly Thr Ile Lys Arg 
        115                 120                 125             


Arg Leu Glu Asn Asn Tyr Tyr Trp Ala Ala Ser Glu Cys Met Gln Asp 
    130                 135                 140                 


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Pro Thr Asp 
145                 150                 155                 160 


Asp Ile Val Leu Met Ala Gln Thr Leu Glu Lys Ile Phe Leu Gln Lys 
                165                 170                 175     


Val Ala Ser Met Pro Gln Glu Glu Gln Glu Leu Val Val Thr Ile Pro 
            180                 185                 190         


Lys Asn Ser His Lys Lys Gly Ala Lys Leu Ala Ala Leu Gln Gly Ser 
        195                 200                 205             


Val Thr Ser Ala His Gln Val Pro Ala Val Ser Ser Val Ser His Thr 
    210                 215                 220                 


Ala Leu Tyr Thr Pro Pro Pro Glu Ile Pro Thr Thr Val Leu Asn Ile 
225                 230                 235                 240 


Pro His Pro Ser Val Ile Ser Ser Pro Leu Leu Lys Ser Leu His Ser 
                245                 250                 255     


Ala Gly Pro Pro Leu Leu Ala Val Thr Ala Ala Pro Pro Ala Gln Pro 
            260                 265                 270         


Leu Ala Lys Lys Lys Gly Val Lys Arg Lys Ala Asp Thr Thr Thr Pro 
        275                 280                 285             


Thr Pro Thr Ala Ile Leu Ala Pro Gly Ser Pro Ala Ser Pro Pro Gly 
    290                 295                 300                 


Ser Leu Glu Pro Lys Ala Ala Arg Leu Pro Pro Met Arg Arg Glu Ser 
305                 310                 315                 320 


Gly Arg Pro Ile Lys Pro Pro Arg Lys Asp Leu Pro Asp Ser Gln Gln 
                325                 330                 335     


Gln His Gln Ser Ser Lys Lys Gly Lys Leu Ser Glu Gln Leu Lys His 
            340                 345                 350         


Cys Asn Gly Ile Leu Lys Glu Leu Leu Ser Lys Lys His Ala Ala Tyr 
        355                 360                 365             


Ala Trp Pro Phe Tyr Lys Pro Val Asp Ala Ser Ala Leu Gly Leu His 
    370                 375                 380                 


Asp Tyr His Asp Ile Ile Lys His Pro Met Asp Leu Ser Thr Val Lys 
385                 390                 395                 400 


Arg Lys Met Glu Asn Arg Asp Tyr Arg Asp Ala Gln Glu Phe Ala Ala 
                405                 410                 415     


Asp Val Arg Leu Met Phe Ser Asn Cys Tyr Lys Tyr Asn Pro Pro Asp 
            420                 425                 430         


His Asp Val Val Ala Met Ala Arg Lys Leu Gln Asp Val Phe Glu Phe 
        435                 440                 445             


Arg Tyr Ala Lys Met Pro Asp Glu Pro Leu Glu Pro Gly Pro Leu Pro 
    450                 455                 460                 


Val Ser Thr Ala Met Pro Pro Gly Leu Ala Lys Ser Ser Ser Glu Ser 
465                 470                 475                 480 


Ser Ser Glu Glu Ser Ser Ser Glu Ser Ser Ser Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Ser Glu Ser Ser Asp Ser 
            500                 505                 510         


Glu Glu Glu Arg Ala His Arg Leu Ala Glu Leu Gln Glu Gln Leu Arg 
        515                 520                 525             


Ala Val His Glu Gln Leu Ala Ala Leu Ser Gln Gly Pro Ile Ser Lys 
    530                 535                 540                 


Pro Lys Arg Lys Arg Glu Lys Lys Glu Lys Lys Lys Lys Arg Lys Ala 
545                 550                 555                 560 


Glu Lys His Arg Gly Arg Ala Gly Ala Asp Glu Asp Asp Lys Gly Pro 
                565                 570                 575     


Arg Ala Pro Arg Pro Pro Gln Pro Lys Lys Ser Lys Lys Ala Ser Gly 
            580                 585                 590         


Ser Gly Gly Gly Ser Ala Ala Leu Gly Pro Ser Gly Phe Gly Pro Ser 
        595                 600                 605             


Gly Gly Ser Gly Thr Lys Leu Gln Ala Gly Val Gln Trp Arg Asp Leu 
    610                 615                 620                 


Gly Leu Leu Gln Pro Pro Leu Leu Gly Phe Lys Arg Phe Ser Cys Leu 
625                 630                 635                 640 


Ser Leu Pro Ser Ser Gln Asp Tyr Arg Leu Pro Lys Lys Ala Thr Lys 
                645                 650                 655     


Thr Ala Pro Pro Ala Leu Pro Thr Gly Tyr Asp Ser Glu Glu Glu Glu 
            660                 665                 670         


Glu Ser Arg Pro Met Ser Tyr Asp Glu Lys Arg Gln Leu Ser Leu Asp 
        675                 680                 685             


Ile Asn Lys Leu Pro Gly Glu Lys Leu Gly Arg Val Val His Ile Ile 
    690                 695                 700                 


Gln Ala Arg Glu Pro Ser Leu Arg Asp Ser Asn Pro Glu Glu Ile Glu 
705                 710                 715                 720 


Ile Asp Phe Glu Thr Leu Lys Pro Ser Thr Leu Arg Glu Leu Glu Arg 
                725                 730                 735     


Tyr Val Leu Ser Cys Leu Arg Lys Lys Pro Arg Lys Pro Tyr Thr Ile 
            740                 745                 750         


Lys Lys Pro Val Gly Lys Thr Lys Glu Glu Leu Ala Leu Glu Lys Lys 
        755                 760                 765             


Arg Glu Leu Glu Lys Arg Leu Gln Asp Val Ser Gly Gln Leu Asn Ser 
    770                 775                 780                 


Thr Lys Lys Pro Pro Lys Lys Ala Asn Glu Lys Thr Glu Ser Ser Ser 
785                 790                 795                 800 


Ala Gln Gln Val Ala Val Ser Arg Leu Ser Ala Ser Ser Ser Ser Ser 
                805                 810                 815     


Asp Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Asp Thr Ser Asp 
            820                 825                 830         


Ser Asp Ser Gly 
        835     


<210>  171
<211>  1054
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Ala Ala Val Lys Glu Pro Leu Glu Phe His Ala Lys Arg Pro Trp 
1               5                   10                  15      


Arg Pro Glu Glu Ala Val Glu Asp Pro Asp Glu Glu Asp Glu Asp Asn 
            20                  25                  30          


Thr Ser Glu Ala Glu Asn Gly Phe Ser Leu Glu Glu Val Leu Arg Leu 
        35                  40                  45              


Gly Gly Thr Lys Gln Asp Tyr Leu Met Leu Ala Thr Leu Asp Glu Asn 
    50                  55                  60                  


Glu Glu Val Ile Asp Gly Gly Lys Lys Gly Ala Ile Asp Asp Leu Gln 
65                  70                  75                  80  


Gln Gly Glu Leu Glu Ala Phe Ile Gln Asn Leu Asn Leu Ala Lys Tyr 
                85                  90                  95      


Thr Lys Ala Ser Leu Val Glu Glu Asp Glu Pro Ala Glu Lys Glu Asn 
            100                 105                 110         


Ser Ser Lys Lys Glu Val Lys Ile Pro Lys Ile Asn Asn Lys Asn Thr 
        115                 120                 125             


Ala Glu Ser Gln Arg Thr Ser Val Asn Lys Val Lys Asn Lys Asn Arg 
    130                 135                 140                 


Pro Glu Pro His Ser Asp Glu Asn Gly Ser Thr Thr Pro Lys Val Lys 
145                 150                 155                 160 


Lys Asp Lys Gln Asn Ile Phe Glu Phe Phe Glu Arg Gln Thr Leu Leu 
                165                 170                 175     


Leu Arg Pro Gly Gly Lys Trp Tyr Asp Leu Glu Tyr Ser Asn Glu Tyr 
            180                 185                 190         


Ser Leu Lys Pro Gln Pro Gln Asp Val Val Ser Lys Tyr Lys Thr Leu 
        195                 200                 205             


Ala Gln Lys Leu Tyr Gln His Glu Ile Asn Leu Phe Lys Ser Lys Thr 
    210                 215                 220                 


Asn Ser Gln Lys Gly Ala Ser Ser Thr Trp Met Lys Ala Ile Val Ser 
225                 230                 235                 240 


Ser Gly Thr Leu Gly Asp Arg Met Ala Ala Met Ile Leu Leu Ile Gln 
                245                 250                 255     


Asp Asp Ala Val His Thr Leu Gln Phe Val Glu Thr Leu Val Asn Leu 
            260                 265                 270         


Val Lys Lys Lys Gly Ser Lys Gln Gln Cys Leu Met Ala Leu Asp Thr 
        275                 280                 285             


Phe Lys Glu Leu Leu Ile Thr Asp Leu Leu Pro Asp Asn Arg Lys Leu 
    290                 295                 300                 


Arg Ile Phe Ser Gln Arg Pro Phe Asp Lys Leu Glu Gln Leu Ser Ser 
305                 310                 315                 320 


Gly Asn Lys Asp Ser Arg Asp Arg Arg Leu Ile Leu Trp Tyr Phe Glu 
                325                 330                 335     


His Gln Leu Lys His Leu Val Ala Glu Phe Val Gln Val Leu Glu Thr 
            340                 345                 350         


Leu Ser His Asp Thr Leu Val Thr Thr Lys Thr Arg Ala Leu Thr Val 
        355                 360                 365             


Ala His Glu Leu Leu Cys Asn Lys Pro Glu Glu Glu Lys Ala Leu Leu 
    370                 375                 380                 


Val Gln Val Val Asn Lys Leu Gly Asp Pro Gln Asn Arg Ile Ala Thr 
385                 390                 395                 400 


Lys Ala Ser His Leu Leu Glu Thr Leu Leu Cys Lys His Pro Asn Met 
                405                 410                 415     


Lys Gly Val Val Ser Gly Glu Val Glu Arg Leu Leu Phe Arg Ser Asn 
            420                 425                 430         


Ile Ser Ser Lys Ala Gln Tyr Tyr Ala Ile Cys Phe Leu Asn Gln Met 
        435                 440                 445             


Ala Leu Ser His Glu Glu Ser Glu Leu Ala Asn Lys Leu Ile Thr Val 
    450                 455                 460                 


Tyr Phe Cys Phe Phe Arg Thr Cys Val Lys Lys Lys Asp Val Glu Ser 
465                 470                 475                 480 


Lys Met Leu Ser Ala Leu Leu Thr Gly Val Asn Arg Ala Tyr Pro Tyr 
                485                 490                 495     


Ser Gln Thr Gly Asp Asp Lys Val Arg Glu Gln Ile Asp Thr Leu Phe 
            500                 505                 510         


Lys Val Leu His Ile Val Asn Phe Asn Thr Ser Val Gln Ala Leu Met 
        515                 520                 525             


Leu Leu Phe Gln Val Met Asn Ser Gln Gln Thr Ile Ser Asp Arg Tyr 
    530                 535                 540                 


Tyr Thr Ala Leu Tyr Arg Lys Met Leu Asp Pro Gly Leu Met Thr Cys 
545                 550                 555                 560 


Ser Lys Gln Ala Met Phe Leu Asn Leu Val Tyr Lys Ser Leu Lys Ala 
                565                 570                 575     


Asp Ile Val Leu Arg Arg Val Lys Ala Phe Val Lys Arg Leu Leu Gln 
            580                 585                 590         


Val Thr Cys Gln Gln Met Pro Pro Phe Ile Cys Gly Ala Leu Tyr Leu 
        595                 600                 605             


Val Ser Glu Ile Leu Lys Ala Lys Pro Gly Leu Arg Ser Gln Leu Asp 
    610                 615                 620                 


Asp His Pro Glu Ser Asp Asp Glu Glu Asn Phe Ile Asp Ala Asn Asp 
625                 630                 635                 640 


Asp Glu Asp Met Glu Lys Phe Thr Asp Ala Asp Lys Glu Thr Glu Ile 
                645                 650                 655     


Val Lys Lys Leu Glu Thr Glu Glu Thr Val Pro Glu Thr Asp Val Glu 
            660                 665                 670         


Thr Lys Lys Pro Glu Val Ala Ser Trp Val His Phe Asp Asn Leu Lys 
        675                 680                 685             


Gly Gly Lys Gln Leu Asn Lys Tyr Asp Pro Phe Ser Arg Asn Pro Leu 
    690                 695                 700                 


Phe Cys Gly Ala Glu Asn Thr Ser Leu Trp Glu Leu Lys Lys Leu Ser 
705                 710                 715                 720 


Val His Phe His Pro Ser Val Ala Leu Phe Ala Lys Thr Ile Leu Gln 
                725                 730                 735     


Gly Asn Tyr Ile Gln Tyr Ser Gly Asp Pro Leu Gln Asp Phe Thr Leu 
            740                 745                 750         


Met Arg Phe Leu Asp Arg Phe Val Tyr Arg Asn Pro Lys Pro His Lys 
        755                 760                 765             


Gly Lys Glu Asn Thr Asp Ser Val Val Met Gln Pro Lys Arg Lys His 
    770                 775                 780                 


Phe Ile Lys Asp Ile Arg His Leu Pro Val Asn Ser Lys Glu Phe Leu 
785                 790                 795                 800 


Ala Lys Glu Glu Ser Gln Ile Pro Val Asp Glu Val Phe Phe His Arg 
                805                 810                 815     


Tyr Tyr Lys Lys Val Ala Val Lys Glu Lys Gln Lys Arg Asp Ala Asp 
            820                 825                 830         


Glu Glu Ser Ile Glu Asp Val Asp Asp Glu Glu Phe Glu Glu Leu Ile 
        835                 840                 845             


Asp Thr Phe Glu Asp Asp Asn Cys Phe Ser Ser Gly Lys Asp Asp Met 
    850                 855                 860                 


Asp Phe Ala Gly Asn Val Lys Lys Arg Thr Lys Gly Ala Lys Asp Asn 
865                 870                 875                 880 


Thr Leu Asp Glu Asp Ser Glu Gly Ser Asp Asp Glu Leu Gly Asn Leu 
                885                 890                 895     


Asp Asp Asp Glu Val Ser Leu Gly Ser Met Asp Asp Glu Glu Phe Ala 
            900                 905                 910         


Glu Val Asp Glu Asp Gly Gly Thr Phe Met Asp Val Leu Asp Asp Glu 
        915                 920                 925             


Ser Glu Ser Val Pro Glu Leu Glu Val His Ser Lys Val Ser Thr Lys 
    930                 935                 940                 


Lys Ser Lys Arg Lys Gly Thr Asp Asp Phe Asp Phe Ala Gly Ser Phe 
945                 950                 955                 960 


Gln Gly Pro Arg Lys Lys Lys Arg Asn Leu Asn Asp Ser Ser Leu Phe 
                965                 970                 975     


Val Ser Ala Glu Glu Phe Gly His Leu Leu Asp Glu Asn Met Gly Ser 
            980                 985                 990         


Lys Phe Asp Asn Ile Gly Met Asn  Ala Met Ala Asn Lys  Asp Asn Ala 
        995                 1000                 1005             


Ser Leu  Lys Gln Leu Arg Trp  Glu Ala Glu Arg Asp  Asp Trp Leu 
    1010                 1015                 1020             


His Asn  Arg Asp Ala Lys Ser  Ile Ile Lys Lys Lys  Lys His Phe 
    1025                 1030                 1035             


Lys Lys  Lys Arg Ile Lys Thr  Thr Gln Lys Thr Lys  Lys Gln Arg 
    1040                 1045                 1050             


Lys 
    


<210>  172
<211>  1710
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Asn Gly His Ser Asp Glu Glu Ser Val Arg Asn Ser Ser Gly Glu 
1               5                   10                  15      


Ser Ser Gln Ser Asp Asp Asp Ser Gly Ser Ala Ser Gly Ser Gly Ser 
            20                  25                  30          


Gly Ser Ser Ser Gly Ser Ser Ser Asp Gly Ser Ser Ser Gln Ser Gly 
        35                  40                  45              


Ser Ser Asp Ser Asp Ser Gly Ser Glu Ser Gly Ser Gln Ser Glu Ser 
    50                  55                  60                  


Glu Ser Asp Thr Ser Arg Glu Asn Lys Val Gln Ala Lys Pro Pro Lys 
65                  70                  75                  80  


Val Asp Gly Ala Glu Phe Trp Lys Ser Ser Pro Ser Ile Leu Ala Val 
                85                  90                  95      


Gln Arg Ser Ala Ile Leu Lys Lys Gln Gln Gln Gln Gln Gln Gln Gln 
            100                 105                 110         


Gln His Gln Ala Ser Ser Asn Ser Gly Ser Glu Glu Asp Ser Ser Ser 
        115                 120                 125             


Ser Glu Asp Ser Asp Asp Ser Ser Ser Glu Val Lys Arg Lys Lys His 
    130                 135                 140                 


Lys Asp Glu Asp Trp Gln Met Ser Gly Ser Gly Ser Pro Ser Gln Ser 
145                 150                 155                 160 


Gly Ser Asp Ser Glu Ser Glu Glu Glu Arg Glu Lys Ser Ser Cys Asp 
                165                 170                 175     


Glu Thr Glu Ser Asp Tyr Glu Pro Lys Asn Lys Val Lys Ser Arg Lys 
            180                 185                 190         


Pro Gln Asn Arg Ser Lys Ser Lys Asn Gly Lys Lys Ile Leu Gly Gln 
        195                 200                 205             


Lys Lys Arg Gln Ile Asp Ser Ser Glu Glu Asp Asp Asp Glu Glu Asp 
    210                 215                 220                 


Tyr Asp Asn Asp Lys Arg Ser Ser Arg Arg Gln Ala Thr Val Asn Val 
225                 230                 235                 240 


Ser Tyr Lys Glu Asp Glu Glu Met Lys Thr Asp Ser Asp Asp Leu Leu 
                245                 250                 255     


Glu Val Cys Gly Glu Asp Val Pro Gln Pro Glu Glu Glu Glu Phe Glu 
            260                 265                 270         


Thr Ile Glu Arg Phe Met Asp Cys Arg Ile Gly Arg Lys Gly Ala Thr 
        275                 280                 285             


Gly Ala Thr Thr Thr Ile Tyr Ala Val Glu Ala Asp Gly Asp Pro Asn 
    290                 295                 300                 


Ala Gly Phe Glu Lys Asn Lys Glu Pro Gly Glu Ile Gln Tyr Leu Ile 
305                 310                 315                 320 


Lys Trp Lys Gly Trp Ser His Ile His Asn Thr Trp Glu Thr Glu Glu 
                325                 330                 335     


Thr Leu Lys Gln Gln Asn Val Arg Gly Met Lys Lys Leu Asp Asn Tyr 
            340                 345                 350         


Lys Lys Lys Asp Gln Glu Thr Lys Arg Trp Leu Lys Asn Ala Ser Pro 
        355                 360                 365             


Glu Asp Val Glu Tyr Tyr Asn Cys Gln Gln Glu Leu Thr Asp Asp Leu 
    370                 375                 380                 


His Lys Gln Tyr Gln Ile Val Glu Arg Ile Ile Ala His Ser Asn Gln 
385                 390                 395                 400 


Lys Ser Ala Ala Gly Tyr Pro Asp Tyr Tyr Cys Lys Trp Gln Gly Leu 
                405                 410                 415     


Pro Tyr Ser Glu Cys Ser Trp Glu Asp Gly Ala Leu Ile Ser Lys Lys 
            420                 425                 430         


Phe Gln Ala Cys Ile Asp Glu Tyr Phe Ser Arg Asn Gln Ser Lys Thr 
        435                 440                 445             


Thr Pro Phe Lys Asp Cys Lys Val Leu Lys Gln Arg Pro Arg Phe Val 
    450                 455                 460                 


Ala Leu Lys Lys Gln Pro Ser Tyr Ile Gly Gly His Glu Gly Leu Glu 
465                 470                 475                 480 


Leu Arg Asp Tyr Gln Leu Asn Gly Leu Asn Trp Leu Ala His Ser Trp 
                485                 490                 495     


Cys Lys Gly Asn Ser Cys Ile Leu Ala Asp Glu Met Gly Leu Gly Lys 
            500                 505                 510         


Thr Ile Gln Thr Ile Ser Phe Leu Asn Tyr Leu Phe His Glu His Gln 
        515                 520                 525             


Leu Tyr Gly Pro Phe Leu Leu Val Val Pro Leu Ser Thr Leu Thr Ser 
    530                 535                 540                 


Trp Gln Arg Glu Ile Gln Thr Trp Ala Ser Gln Met Asn Ala Val Val 
545                 550                 555                 560 


Tyr Leu Gly Asp Ile Asn Ser Arg Asn Met Ile Arg Thr His Glu Trp 
                565                 570                 575     


Thr His His Gln Thr Lys Arg Leu Lys Phe Asn Ile Leu Leu Thr Thr 
            580                 585                 590         


Tyr Glu Ile Leu Leu Lys Asp Lys Ala Phe Leu Gly Gly Leu Asn Trp 
        595                 600                 605             


Ala Phe Ile Gly Val Asp Glu Ala His Arg Leu Lys Asn Asp Asp Ser 
    610                 615                 620                 


Leu Leu Tyr Lys Thr Leu Ile Asp Phe Lys Ser Asn His Arg Leu Leu 
625                 630                 635                 640 


Ile Thr Gly Thr Pro Leu Gln Asn Ser Leu Lys Glu Leu Trp Ser Leu 
                645                 650                 655     


Leu His Phe Ile Met Pro Glu Lys Phe Ser Ser Trp Glu Asp Phe Glu 
            660                 665                 670         


Glu Glu His Gly Lys Gly Arg Glu Tyr Gly Tyr Ala Ser Leu His Lys 
        675                 680                 685             


Glu Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp Val Glu Lys 
    690                 695                 700                 


Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Met Glu Met Ser Ala 
705                 710                 715                 720 


Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Thr Arg Asn Tyr Lys Ala 
                725                 730                 735     


Leu Ser Lys Gly Ser Lys Gly Ser Thr Ser Gly Phe Leu Asn Ile Met 
            740                 745                 750         


Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile Lys Pro Pro 
        755                 760                 765             


Asp Asn Asn Glu Phe Tyr Asn Lys Gln Glu Ala Leu Gln His Leu Ile 
    770                 775                 780                 


Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu Ile Arg Leu 
785                 790                 795                 800 


Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met Val Arg Met 
                805                 810                 815     


Leu Asp Ile Leu Ala Glu Tyr Leu Lys Tyr Arg Gln Phe Pro Phe Gln 
            820                 825                 830         


Arg Leu Asp Gly Ser Ile Lys Gly Glu Leu Arg Lys Gln Ala Leu Asp 
        835                 840                 845             


His Phe Asn Ala Glu Gly Ser Glu Asp Phe Cys Phe Leu Leu Ser Thr 
    850                 855                 860                 


Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp Thr Val Val 
865                 870                 875                 880 


Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln Ala Gln Ala 
                885                 890                 895     


Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile Tyr Arg Leu 
            900                 905                 910         


Val Thr Lys Gly Ser Val Glu Glu Asp Ile Leu Glu Arg Ala Lys Lys 
        915                 920                 925             


Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp Thr Thr Gly 
    930                 935                 940                 


Lys Thr Val Leu His Thr Gly Ser Ala Pro Ser Ser Ser Thr Pro Phe 
945                 950                 955                 960 


Asn Lys Glu Glu Leu Ser Ala Ile Leu Lys Phe Gly Ala Glu Glu Leu 
                965                 970                 975     


Phe Lys Glu Pro Glu Gly Glu Glu Gln Glu Pro Gln Glu Met Asp Ile 
            980                 985                 990         


Asp Glu Ile Leu Lys Arg Ala Glu  Thr His Glu Asn Glu  Pro Gly Pro 
        995                 1000                 1005             


Leu Thr  Val Gly Asp Glu Leu  Leu Ser Gln Phe Lys  Val Ala Asn 
    1010                 1015                 1020             


Phe Ser  Asn Met Asp Glu Asp  Asp Ile Glu Leu Glu  Pro Glu Arg 
    1025                 1030                 1035             


Asn Ser  Lys Asn Trp Glu Glu  Ile Ile Pro Glu Asp  Gln Arg Arg 
    1040                 1045                 1050             


Arg Leu  Glu Glu Glu Glu Arg  Gln Lys Glu Leu Glu  Glu Ile Tyr 
    1055                 1060                 1065             


Met Leu  Pro Arg Met Arg Asn  Cys Ala Lys Gln Ile  Ser Phe Asn 
    1070                 1075                 1080             


Gly Ser  Glu Gly Arg Arg Ser  Arg Ser Arg Arg Tyr  Ser Gly Ser 
    1085                 1090                 1095             


Asp Ser  Asp Ser Ile Ser Glu  Gly Lys Arg Pro Lys  Lys Arg Gly 
    1100                 1105                 1110             


Arg Pro  Arg Thr Ile Pro Arg  Glu Asn Ile Lys Gly  Phe Ser Asp 
    1115                 1120                 1125             


Ala Glu  Ile Arg Arg Phe Ile  Lys Ser Tyr Lys Lys  Phe Gly Gly 
    1130                 1135                 1140             


Pro Leu  Glu Arg Leu Asp Ala  Ile Ala Arg Asp Ala  Glu Leu Val 
    1145                 1150                 1155             


Asp Lys  Ser Glu Thr Asp Leu  Arg Arg Leu Gly Glu  Leu Val His 
    1160                 1165                 1170             


Asn Gly  Cys Ile Lys Ala Leu  Lys Asp Ser Ser Ser  Gly Thr Glu 
    1175                 1180                 1185             


Arg Thr  Gly Gly Arg Leu Gly  Lys Val Lys Gly Pro  Thr Phe Arg 
    1190                 1195                 1200             


Ile Ser  Gly Val Gln Val Asn  Ala Lys Leu Val Ile  Ser His Glu 
    1205                 1210                 1215             


Glu Glu  Leu Ile Pro Leu His  Lys Ser Ile Pro Ser  Asp Pro Glu 
    1220                 1225                 1230             


Glu Arg  Lys Gln Tyr Thr Ile  Pro Cys His Thr Lys  Ala Ala His 
    1235                 1240                 1245             


Phe Asp  Ile Asp Trp Gly Lys  Glu Asp Asp Ser Asn  Leu Leu Ile 
    1250                 1255                 1260             


Gly Ile  Tyr Glu Tyr Gly Tyr  Gly Ser Trp Glu Met  Ile Lys Met 
    1265                 1270                 1275             


Asp Pro  Asp Leu Ser Leu Thr  His Lys Ile Leu Pro  Asp Asp Pro 
    1280                 1285                 1290             


Asp Lys  Lys Pro Gln Ala Lys  Gln Leu Gln Thr Arg  Ala Asp Tyr 
    1295                 1300                 1305             


Leu Ile  Lys Leu Leu Ser Arg  Asp Leu Ala Lys Lys  Glu Ala Leu 
    1310                 1315                 1320             


Ser Gly  Ala Gly Ser Ser Lys  Arg Arg Lys Ala Arg  Ala Lys Lys 
    1325                 1330                 1335             


Asn Lys  Ala Met Lys Ser Ile  Lys Val Lys Glu Glu  Ile Lys Ser 
    1340                 1345                 1350             


Asp Ser  Ser Pro Leu Pro Ser  Glu Lys Ser Asp Glu  Asp Asp Asp 
    1355                 1360                 1365             


Lys Leu  Ser Glu Ser Lys Ser  Asp Gly Arg Glu Arg  Ser Lys Lys 
    1370                 1375                 1380             


Ser Ser  Val Ser Asp Ala Pro  Val His Ile Thr Ala  Ser Gly Glu 
    1385                 1390                 1395             


Pro Val  Pro Ile Ser Glu Glu  Ser Glu Glu Leu Asp  Gln Lys Thr 
    1400                 1405                 1410             


Phe Ser  Ile Cys Lys Glu Arg  Met Arg Pro Val Lys  Ala Ala Leu 
    1415                 1420                 1425             


Lys Gln  Leu Asp Arg Pro Glu  Lys Gly Leu Ser Glu  Arg Glu Gln 
    1430                 1435                 1440             


Leu Glu  His Thr Arg Gln Cys  Leu Ile Lys Ile Gly  Asp His Ile 
    1445                 1450                 1455             


Thr Glu  Cys Leu Lys Glu Tyr  Thr Asn Pro Glu Gln  Ile Lys Gln 
    1460                 1465                 1470             


Trp Arg  Lys Asn Leu Trp Ile  Phe Val Ser Lys Phe  Thr Glu Phe 
    1475                 1480                 1485             


Asp Ala  Arg Lys Leu His Lys  Leu Tyr Lys His Ala  Ile Lys Lys 
    1490                 1495                 1500             


Arg Gln  Glu Ser Gln Gln Asn  Ser Asp Gln Asn Ser  Asn Leu Asn 
    1505                 1510                 1515             


Pro His  Val Ile Arg Asn Pro  Asp Val Glu Arg Leu  Lys Glu Asn 
    1520                 1525                 1530             


Thr Asn  His Asp Asp Ser Ser  Arg Asp Ser Tyr Ser  Ser Asp Arg 
    1535                 1540                 1545             


His Leu  Thr Gln Tyr His Asp  His His Lys Asp Arg  His Gln Gly 
    1550                 1555                 1560             


Asp Ser  Tyr Lys Lys Ser Asp  Ser Arg Lys Arg Pro  Tyr Ser Ser 
    1565                 1570                 1575             


Phe Ser  Asn Gly Lys Asp His  Arg Asp Trp Asp His  Tyr Lys Gln 
    1580                 1585                 1590             


Asp Ser  Arg Tyr Tyr Ser Asp  Arg Glu Lys His Arg  Lys Leu Asp 
    1595                 1600                 1605             


Asp His  Arg Ser Arg Asp His  Arg Ser Asn Leu Glu  Gly Ser Leu 
    1610                 1615                 1620             


Lys Asp  Arg Ser His Ser Asp  His Arg Ser His Ser  Asp His Arg 
    1625                 1630                 1635             


Leu His  Ser Asp His Arg Ser  Ser Ser Glu Tyr Thr  His His Lys 
    1640                 1645                 1650             


Ser Ser  Arg Asp Tyr Arg Tyr  His Ser Asp Trp Gln  Met Asp His 
    1655                 1660                 1665             


Arg Ala  Ser Ser Ser Gly Pro  Arg Ser Pro Leu Asp  Gln Arg Ser 
    1670                 1675                 1680             


Pro Tyr  Gly Ser Arg Ser Pro  Phe Glu His Ser Val  Glu His Lys 
    1685                 1690                 1695             


Ser Thr  Pro Glu His Thr Trp  Ser Ser Arg Lys Thr  
    1700                 1705                 1710 


<210>  173
<211>  2240
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Asp Asp Lys Gly Asp Pro Ser Asn Glu Glu Ala Pro Lys Ala Ile 
1               5                   10                  15      


Lys Pro Thr Ser Lys Glu Phe Arg Lys Thr Trp Gly Phe Arg Arg Thr 
            20                  25                  30          


Thr Ile Ala Lys Arg Glu Gly Ala Gly Asp Ala Glu Ala Asp Pro Leu 
        35                  40                  45              


Glu Pro Pro Pro Pro Gln Gln Gln Leu Gly Leu Ser Leu Arg Arg Ser 
    50                  55                  60                  


Gly Arg Gln Pro Lys Arg Thr Glu Arg Val Glu Gln Phe Leu Thr Ile 
65                  70                  75                  80  


Ala Arg Arg Arg Gly Arg Arg Ser Met Pro Val Ser Leu Glu Asp Ser 
                85                  90                  95      


Gly Glu Pro Thr Ser Cys Pro Ala Thr Asp Ala Glu Thr Ala Ser Glu 
            100                 105                 110         


Gly Ser Val Glu Ser Ala Ser Glu Thr Arg Ser Gly Pro Gln Ser Ala 
        115                 120                 125             


Ser Thr Ala Val Lys Glu Arg Pro Ala Ser Ser Glu Lys Val Lys Gly 
    130                 135                 140                 


Gly Asp Asp His Asp Asp Thr Ser Asp Ser Asp Ser Asp Gly Leu Thr 
145                 150                 155                 160 


Leu Lys Glu Leu Gln Asn Arg Leu Arg Arg Lys Arg Glu Gln Glu Pro 
                165                 170                 175     


Thr Glu Arg Pro Leu Lys Gly Ile Gln Ser Arg Leu Arg Lys Lys Arg 
            180                 185                 190         


Arg Glu Glu Gly Pro Ala Glu Thr Val Gly Ser Glu Ala Ser Asp Thr 
        195                 200                 205             


Val Glu Gly Val Leu Pro Ser Lys Gln Glu Pro Glu Asn Asp Gln Gly 
    210                 215                 220                 


Val Val Ser Gln Ala Gly Lys Asp Asp Arg Glu Ser Lys Leu Glu Gly 
225                 230                 235                 240 


Lys Ala Ala Gln Asp Ile Lys Asp Glu Glu Pro Gly Asp Leu Gly Arg 
                245                 250                 255     


Pro Lys Pro Glu Cys Glu Gly Tyr Asp Pro Asn Ala Leu Tyr Cys Ile 
            260                 265                 270         


Cys Arg Gln Pro His Asn Asn Arg Phe Met Ile Cys Cys Asp Arg Cys 
        275                 280                 285             


Glu Glu Trp Phe His Gly Asp Cys Val Gly Ile Ser Glu Ala Arg Gly 
    290                 295                 300                 


Arg Leu Leu Glu Arg Asn Gly Glu Asp Tyr Ile Cys Pro Asn Cys Thr 
305                 310                 315                 320 


Ile Leu Gln Val Gln Asp Glu Thr His Ser Glu Thr Ala Asp Gln Gln 
                325                 330                 335     


Glu Ala Lys Trp Arg Pro Gly Asp Ala Asp Gly Thr Asp Cys Thr Ser 
            340                 345                 350         


Ile Gly Thr Ile Glu Gln Lys Ser Ser Glu Asp Gln Gly Ile Lys Gly 
        355                 360                 365             


Arg Ile Glu Lys Ala Ala Asn Pro Ser Gly Lys Lys Lys Leu Lys Ile 
    370                 375                 380                 


Phe Gln Pro Val Ile Glu Ala Pro Gly Ala Ser Lys Cys Ile Gly Pro 
385                 390                 395                 400 


Gly Cys Cys His Val Ala Gln Pro Asp Ser Val Tyr Cys Ser Asn Asp 
                405                 410                 415     


Cys Ile Leu Lys His Ala Ala Ala Thr Met Lys Phe Leu Ser Ser Gly 
            420                 425                 430         


Lys Glu Gln Lys Pro Lys Pro Lys Glu Lys Met Lys Met Lys Pro Glu 
        435                 440                 445             


Lys Pro Ser Leu Pro Lys Cys Gly Ala Gln Ala Gly Ile Lys Ile Ser 
    450                 455                 460                 


Ser Val His Lys Arg Pro Ala Pro Glu Lys Lys Glu Thr Thr Val Lys 
465                 470                 475                 480 


Lys Ala Val Val Val Pro Ala Arg Ser Glu Ala Leu Gly Lys Glu Ala 
                485                 490                 495     


Ala Cys Glu Ser Ser Thr Pro Ser Trp Ala Ser Asp His Asn Tyr Asn 
            500                 505                 510         


Ala Val Lys Pro Glu Lys Thr Ala Ala Pro Ser Pro Ser Leu Leu Tyr 
        515                 520                 525             


Lys Ser Thr Lys Glu Asp Arg Arg Ser Glu Glu Lys Ala Ala Ala Met 
    530                 535                 540                 


Ala Ala Ser Lys Lys Thr Ala Pro Pro Gly Ser Ala Val Gly Lys Gln 
545                 550                 555                 560 


Pro Ala Pro Arg Asn Leu Val Pro Lys Lys Ser Ser Phe Ala Asn Val 
                565                 570                 575     


Ala Ala Ala Thr Pro Ala Ile Lys Lys Pro Pro Ser Gly Phe Lys Gly 
            580                 585                 590         


Thr Ile Pro Lys Arg Pro Trp Leu Ser Ala Thr Pro Ser Ser Gly Ala 
        595                 600                 605             


Ser Ala Ala Arg Gln Ala Gly Pro Ala Pro Ala Ala Ala Thr Ala Ala 
    610                 615                 620                 


Ser Lys Lys Phe Pro Gly Ser Ala Ala Leu Val Gly Ala Val Arg Lys 
625                 630                 635                 640 


Pro Val Val Pro Ser Val Pro Met Ala Ser Pro Ala Pro Gly Arg Leu 
                645                 650                 655     


Gly Ala Met Ser Ala Ala Pro Ser Gln Pro Asn Ser Gln Ile Arg Gln 
            660                 665                 670         


Asn Ile Arg Arg Ser Leu Lys Glu Ile Leu Trp Lys Arg Val Asn Asp 
        675                 680                 685             


Ser Asp Asp Leu Ile Met Thr Glu Asn Glu Val Gly Lys Ile Ala Leu 
    690                 695                 700                 


His Ile Glu Lys Glu Met Phe Asn Leu Phe Gln Val Thr Asp Asn Arg 
705                 710                 715                 720 


Tyr Lys Ser Lys Tyr Arg Ser Ile Met Phe Asn Leu Lys Asp Pro Lys 
                725                 730                 735     


Asn Gln Gly Leu Phe His Arg Val Leu Arg Glu Glu Ile Ser Leu Ala 
            740                 745                 750         


Lys Leu Val Arg Leu Lys Pro Glu Glu Leu Val Ser Lys Glu Leu Ser 
        755                 760                 765             


Thr Trp Lys Glu Arg Pro Ala Arg Ser Val Met Glu Ser Arg Thr Lys 
    770                 775                 780                 


Leu His Asn Glu Ser Lys Lys Thr Ala Pro Arg Gln Glu Ala Ile Pro 
785                 790                 795                 800 


Asp Leu Glu Asp Ser Pro Pro Val Ser Asp Ser Glu Glu Gln Gln Glu 
                805                 810                 815     


Ser Ala Arg Ala Val Pro Glu Lys Ser Thr Ala Pro Leu Leu Asp Val 
            820                 825                 830         


Phe Ser Ser Met Leu Lys Asp Thr Thr Ser Gln His Arg Ala His Leu 
        835                 840                 845             


Phe Asp Leu Asn Cys Lys Ile Cys Thr Gly Gln Val Pro Ser Ala Glu 
    850                 855                 860                 


Asp Glu Pro Ala Pro Lys Lys Gln Lys Leu Ser Ala Ser Val Lys Lys 
865                 870                 875                 880 


Glu Asp Leu Lys Ser Lys His Asp Ser Ser Ala Pro Asp Pro Ala Pro 
                885                 890                 895     


Asp Ser Ala Asp Glu Val Met Pro Glu Ala Val Pro Glu Val Ala Ser 
            900                 905                 910         


Glu Pro Gly Leu Glu Ser Ala Ser His Pro Asn Val Asp Arg Thr Tyr 
        915                 920                 925             


Phe Pro Gly Pro Pro Gly Asp Gly His Pro Glu Pro Ser Pro Leu Glu 
    930                 935                 940                 


Asp Leu Ser Pro Cys Pro Ala Ser Cys Gly Ser Gly Val Val Thr Thr 
945                 950                 955                 960 


Val Thr Val Ser Gly Arg Asp Pro Arg Thr Ala Pro Ser Ser Ser Cys 
                965                 970                 975     


Thr Ala Val Ala Ser Ala Ala Ser Arg Pro Asp Ser Thr His Met Val 
            980                 985                 990         


Glu Ala Arg Gln Asp Val Pro Lys  Pro Val Leu Thr Ser  Val Met Val 
        995                 1000                 1005             


Pro Lys  Ser Ile Leu Ala Lys  Pro Ser Ser Ser Pro  Asp Pro Arg 
    1010                 1015                 1020             


Tyr Leu  Ser Val Pro Pro Ser  Pro Asn Ile Ser Thr  Ser Glu Ser 
    1025                 1030                 1035             


Arg Ser  Pro Pro Glu Gly Asp  Thr Thr Leu Phe Leu  Ser Arg Leu 
    1040                 1045                 1050             


Ser Thr  Ile Trp Lys Gly Phe  Ile Asn Met Gln Ser  Val Ala Lys 
    1055                 1060                 1065             


Phe Val  Thr Lys Ala Tyr Pro  Val Ser Gly Cys Phe  Asp Tyr Leu 
    1070                 1075                 1080             


Ser Glu  Asp Leu Pro Asp Thr  Ile His Ile Gly Gly  Arg Ile Ala 
    1085                 1090                 1095             


Pro Lys  Thr Val Trp Asp Tyr  Val Gly Lys Leu Lys  Ser Ser Val 
    1100                 1105                 1110             


Ser Lys  Glu Leu Cys Leu Ile  Arg Phe His Pro Ala  Thr Glu Glu 
    1115                 1120                 1125             


Glu Glu  Val Ala Tyr Ile Ser  Leu Tyr Ser Tyr Phe  Ser Ser Arg 
    1130                 1135                 1140             


Gly Arg  Phe Gly Val Val Ala  Asn Asn Asn Arg His  Val Lys Asp 
    1145                 1150                 1155             


Leu Tyr  Leu Ile Pro Leu Ser  Ala Gln Asp Pro Val  Pro Ser Lys 
    1160                 1165                 1170             


Leu Leu  Pro Phe Glu Gly Pro  Gly Leu Glu Ser Pro  Arg Pro Asn 
    1175                 1180                 1185             


Ile Ile  Leu Gly Leu Val Ile  Cys Gln Lys Ile Lys  Arg Pro Ala 
    1190                 1195                 1200             


Asn Ser  Gly Glu Leu Asp Lys  Met Asp Glu Lys Arg  Thr Arg Leu 
    1205                 1210                 1215             


Gln Pro  Glu Glu Ala Asp Val  Pro Ala Tyr Pro Lys  Val Ala Thr 
    1220                 1225                 1230             


Val Pro  Gln Ser Glu Lys Lys  Pro Ser Lys Tyr Pro  Leu Cys Ser 
    1235                 1240                 1245             


Ala Asp  Ala Ala Val Ser Thr  Thr Pro Pro Gly Ser  Pro Pro Pro 
    1250                 1255                 1260             


Pro Pro  Pro Leu Pro Glu Pro  Pro Val Leu Lys Val  Leu Ser Ser 
    1265                 1270                 1275             


Leu Lys  Pro Ala Ala Pro Ser  Pro Ala Thr Ala Ala  Thr Thr Ala 
    1280                 1285                 1290             


Ala Ala  Ala Ser Thr Ala Ala  Ser Ser Thr Ala Ser  Ser Ala Ser 
    1295                 1300                 1305             


Lys Thr  Ala Ser Pro Leu Glu  His Ile Leu Gln Thr  Leu Phe Gly 
    1310                 1315                 1320             


Lys Lys  Lys Ser Phe Asp Pro  Ser Ala Arg Glu Pro  Pro Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gly Leu Pro Gln Glu  Pro Lys Thr Thr Ala  Glu Asp Gly 
    1340                 1345                 1350             


Val Pro  Ala Pro Pro Leu Leu  Asp Pro Ile Val Gln  Gln Phe Gly 
    1355                 1360                 1365             


Gln Phe  Ser Lys Asp Lys Ala  Leu Glu Glu Glu Glu  Asp Asp Arg 
    1370                 1375                 1380             


Pro Tyr  Asp Pro Glu Glu Glu  Tyr Asp Pro Glu Arg  Ala Phe Asp 
    1385                 1390                 1395             


Thr Gln  Leu Val Glu Arg Gly  Arg Arg His Glu Val  Glu Arg Ala 
    1400                 1405                 1410             


Pro Glu  Ala Ala Ala Ala Glu  Arg Glu Glu Val Ala  Tyr Asp Pro 
    1415                 1420                 1425             


Glu Asp  Glu Thr Ile Leu Glu  Glu Ala Lys Val Thr  Val Asp Asp 
    1430                 1435                 1440             


Leu Pro  Asn Arg Met Cys Ala  Asp Val Arg Arg Asn  Ser Val Glu 
    1445                 1450                 1455             


Arg Pro  Ala Glu Pro Val Ala  Gly Ala Ala Thr Pro  Ser Leu Val 
    1460                 1465                 1470             


Glu Gln  Gln Lys Met Leu Glu  Glu Leu Asn Lys Gln  Ile Glu Glu 
    1475                 1480                 1485             


Gln Lys  Arg Gln Leu Glu Glu  Gln Glu Glu Ala Leu  Arg Gln Gln 
    1490                 1495                 1500             


Arg Ala  Ala Val Gly Val Ser  Met Ala His Phe Ser  Val Ser Asp 
    1505                 1510                 1515             


Ala Leu  Met Ser Pro Pro Pro  Lys Ser Ser Leu Pro  Lys Ala Glu 
    1520                 1525                 1530             


Leu Phe  Gln Gln Glu Gln Gln  Ser Ala Asp Lys Pro  Ala Ser Leu 
    1535                 1540                 1545             


Pro Pro  Ala Ser Gln Ala Ser  Asn His Arg Asp Pro  Arg Gln Ala 
    1550                 1555                 1560             


Arg Arg  Leu Ala Thr Glu Thr  Gly Glu Gly Glu Gly  Glu Pro Leu 
    1565                 1570                 1575             


Ser Arg  Leu Ser Ala Arg Gly  Ala Gln Gly Ala Leu  Pro Glu Arg 
    1580                 1585                 1590             


Asp Ala  Ser Arg Gly Gly Leu  Val Gly Gln Ala Pro  Met Pro Val 
    1595                 1600                 1605             


Pro Glu  Glu Lys Glu Pro Ala  Ser Ser Pro Trp Ala  Ser Gly Glu 
    1610                 1615                 1620             


Lys Pro  Pro Ala Gly Ser Glu  Gln Asp Gly Trp Lys  Ala Glu Pro 
    1625                 1630                 1635             


Gly Glu  Gly Thr Arg Pro Ala  Thr Val Gly Asp Ser  Ser Ala Arg 
    1640                 1645                 1650             


Pro Ala  Arg Arg Val Leu Leu  Pro Thr Pro Pro Cys  Gly Ala Leu 
    1655                 1660                 1665             


Gln Pro  Gly Phe Pro Leu Gln  His Asp Gly Glu Arg  Asp Pro Phe 
    1670                 1675                 1680             


Thr Cys  Pro Gly Phe Ala Ser  Gln Asp Lys Ala Leu  Gly Ser Ala 
    1685                 1690                 1695             


Gln Tyr  Glu Asp Pro Arg Asn  Leu His Ser Ala Gly  Arg Ser Ser 
    1700                 1705                 1710             


Ser Pro  Ala Gly Glu Thr Glu  Gly Asp Arg Glu Pro  Gln Ala Arg 
    1715                 1720                 1725             


Pro Gly  Glu Gly Thr Ala Pro  Leu Pro Pro Pro Gly  Gln Lys Val 
    1730                 1735                 1740             


Gly Gly  Ser Gln Pro Pro Phe  Gln Gly Gln Arg Glu  Pro Gly Pro 
    1745                 1750                 1755             


His Ala  Leu Gly Met Ser Gly  Leu His Gly Pro Asn  Phe Pro Gly 
    1760                 1765                 1770             


Pro Arg  Gly Pro Ala Pro Pro  Phe Pro Glu Glu Asn  Ile Ala Ser 
    1775                 1780                 1785             


Asn Asp  Gly Pro Arg Gly Pro  Pro Pro Ala Arg Phe  Gly Ala Gln 
    1790                 1795                 1800             


Lys Gly  Pro Ile Pro Ser Leu  Phe Ser Gly Gln His  Gly Pro Pro 
    1805                 1810                 1815             


Pro Tyr  Gly Asp Ser Arg Gly  Pro Ser Pro Ser Tyr  Leu Gly Gly 
    1820                 1825                 1830             


Pro Arg  Gly Val Ala Pro Ser  Gln Phe Glu Glu Arg  Lys Asp Pro 
    1835                 1840                 1845             


His Gly  Glu Lys Arg Glu Phe  Gln Asp Ala Pro Tyr  Asn Glu Val 
    1850                 1855                 1860             


Thr Gly  Ala Pro Ala Gln Phe  Glu Gly Thr Glu Gln  Ala Pro Phe 
    1865                 1870                 1875             


Leu Gly  Ser Arg Gly Gly Ala  Pro Phe Gln Phe Gly  Gly Gln Arg 
    1880                 1885                 1890             


Arg Pro  Leu Leu Ser Gln Leu  Lys Gly Pro Arg Gly  Gly Pro Pro 
    1895                 1900                 1905             


Pro Ser  Gln Phe Gly Gly Gln  Arg Gly Pro Pro Pro  Gly His Phe 
    1910                 1915                 1920             


Val Gly  Pro Arg Gly Pro His  Pro Ser Gln Phe Glu  Thr Ala Arg 
    1925                 1930                 1935             


Gly Pro  His Pro Asn Gln Phe  Glu Gly Pro Arg Gly  Gln Ala Pro 
    1940                 1945                 1950             


Asn Phe  Met Pro Gly Pro Arg  Gly Ile Gln Pro Gln  Gln Phe Glu 
    1955                 1960                 1965             


Asp Gln  Arg Val His Ser Pro  Pro Arg Phe Thr Asn  Gln Arg Ala 
    1970                 1975                 1980             


Pro Ala  Pro Leu Gln Phe Gly  Gly Leu Arg Gly Ser  Ala Pro Phe 
    1985                 1990                 1995             


Ser Glu  Lys Asn Glu Gln Thr  Pro Ser Arg Phe His  Phe Gln Gly 
    2000                 2005                 2010             


Gln Ala  Pro Gln Val Met Lys  Pro Gly Pro Arg Pro  Leu Leu Glu 
    2015                 2020                 2025             


Leu Pro  Ser His Pro Pro Gln  His Arg Lys Asp Arg  Trp Glu Glu 
    2030                 2035                 2040             


Ala Gly  Pro Pro Ser Ala Leu  Ser Ser Ser Ala Pro  Gly Gln Gly 
    2045                 2050                 2055             


Pro Glu  Ala Asp Gly Gln Trp  Ala Ser Ala Asp Phe  Arg Glu Gly 
    2060                 2065                 2070             


Lys Gly  His Glu Tyr Arg Asn  Gln Thr Phe Glu Gly  Arg Gln Arg 
    2075                 2080                 2085             


Glu Arg  Phe Asp Val Gly Pro  Lys Glu Lys Pro Leu  Glu Glu Pro 
    2090                 2095                 2100             


Asp Ala  Gln Gly Arg Ala Ser  Glu Asp Arg Arg Arg  Glu Arg Glu 
    2105                 2110                 2115             


Arg Gly  Arg Asn Trp Ser Arg  Glu Arg Asp Trp Asp  Arg Pro Arg 
    2120                 2125                 2130             


Glu Trp  Asp Arg His Arg Asp  Lys Asp Ser Ser Arg  Asp Trp Asp 
    2135                 2140                 2145             


Arg Asn  Arg Glu Arg Ser Ala  Asn Arg Asp Arg Glu  Arg Glu Ala 
    2150                 2155                 2160             


Asp Arg  Gly Lys Glu Trp Asp  Arg Ser Arg Glu Arg  Ser Arg Asn 
    2165                 2170                 2175             


Arg Glu  Arg Glu Arg Asp Arg  Arg Arg Asp Arg Asp  Arg Ser Arg 
    2180                 2185                 2190             


Ser Arg  Glu Arg Asp Arg Asp  Lys Ala Arg Asp Arg  Glu Arg Gly 
    2195                 2200                 2205             


Arg Asp  Arg Lys Asp Arg Ser  Lys Ser Lys Glu Ser  Ala Arg Asp 
    2210                 2215                 2220             


Pro Lys  Pro Glu Ala Ser Arg  Ala Ser Asp Ala Gly  Thr Ala Ser 
    2225                 2230                 2235             


Gln Ala  
    2240 


<210>  174
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Ala Ser Ser Ser Gly Asn Asp Asp Asp Leu Thr Ile Pro Arg Ala 
1               5                   10                  15      


Ala Ile Asn Lys Met Ile Lys Glu Thr Leu Pro Asn Val Arg Val Ala 
            20                  25                  30          


Asn Asp Ala Arg Glu Leu Val Val Asn Cys Cys Thr Glu Phe Ile His 
        35                  40                  45              


Leu Ile Ser Ser Glu Ala Asn Glu Ile Cys Asn Lys Ser Glu Lys Lys 
    50                  55                  60                  


Thr Ile Ser Pro Glu His Val Ile Gln Ala Leu Glu Ser Leu Gly Phe 
65                  70                  75                  80  


Gly Ser Tyr Ile Ser Glu Val Lys Glu Val Leu Gln Glu Cys Lys Thr 
                85                  90                  95      


Val Ala Leu Lys Arg Arg Lys Ala Ser Ser Arg Leu Glu Asn Leu Gly 
            100                 105                 110         


Ile Pro Glu Glu Glu Leu Leu Arg Gln Gln Gln Glu Leu Phe Ala Lys 
        115                 120                 125             


Ala Arg Gln Gln Gln Ala Glu Leu Ala Gln Gln Glu Trp Leu Gln Met 
    130                 135                 140                 


Gln Gln Ala Ala Gln Gln Ala Gln Leu Ala Ala Ala Ser Ala Ser Ala 
145                 150                 155                 160 


Ser Asn Gln Ala Gly Ser Ser Gln Asp Glu Glu Asp Asp Asp Asp Ile 
                165                 170                 175     


<210>  175
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Ala Ala Ala Lys Ala Glu Met Gln Leu Met Ser Pro Leu Gln Ile 
1               5                   10                  15      


Ser Asp Pro Phe Gly Ser Phe Pro His Ser Pro Thr Met Asp Asn Tyr 
            20                  25                  30          


Pro Lys Leu Glu Glu Met Met Leu Leu Ser Asn Gly Ala Pro Gln Phe 
        35                  40                  45              


Leu Gly Ala Ala Gly Ala Pro Glu Gly Ser Gly Ser Asn Ser Ser Ser 
    50                  55                  60                  


Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser Asn Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Thr Phe Asn Pro Gln Ala Asp Thr Gly Glu Gln Pro 
                85                  90                  95      


Tyr Glu His Leu Thr Ala Glu Ser Phe Pro Asp Ile Ser Leu Asn Asn 
            100                 105                 110         


Glu Lys Val Leu Val Glu Thr Ser Tyr Pro Ser Gln Thr Thr Arg Leu 
        115                 120                 125             


Pro Pro Ile Thr Tyr Thr Gly Arg Phe Ser Leu Glu Pro Ala Pro Asn 
    130                 135                 140                 


Ser Gly Asn Thr Leu Trp Pro Glu Pro Leu Phe Ser Leu Val Ser Gly 
145                 150                 155                 160 


Leu Val Ser Met Thr Asn Pro Pro Ala Ser Ser Ser Ser Ala Pro Ser 
                165                 170                 175     


Pro Ala Ala Ser Ser Ala Ser Ala Ser Gln Ser Pro Pro Leu Ser Cys 
            180                 185                 190         


Ala Val Pro Ser Asn Asp Ser Ser Pro Ile Tyr Ser Ala Ala Pro Thr 
        195                 200                 205             


Phe Pro Thr Pro Asn Thr Asp Ile Phe Pro Glu Pro Gln Ser Gln Ala 
    210                 215                 220                 


Phe Pro Gly Ser Ala Gly Thr Ala Leu Gln Tyr Pro Pro Pro Ala Tyr 
225                 230                 235                 240 


Pro Ala Ala Lys Gly Gly Phe Gln Val Pro Met Ile Pro Asp Tyr Leu 
                245                 250                 255     


Phe Pro Gln Gln Gln Gly Asp Leu Gly Leu Gly Thr Pro Asp Gln Lys 
            260                 265                 270         


Pro Phe Gln Gly Leu Glu Ser Arg Thr Gln Gln Pro Ser Leu Thr Pro 
        275                 280                 285             


Leu Ser Thr Ile Lys Ala Phe Ala Thr Gln Ser Gly Ser Gln Asp Leu 
    290                 295                 300                 


Lys Ala Leu Asn Thr Ser Tyr Gln Ser Gln Leu Ile Lys Pro Ser Arg 
305                 310                 315                 320 


Met Arg Lys Tyr Pro Asn Arg Pro Ser Lys Thr Pro Pro His Glu Arg 
                325                 330                 335     


Pro Tyr Ala Cys Pro Val Glu Ser Cys Asp Arg Arg Phe Ser Arg Ser 
            340                 345                 350         


Asp Glu Leu Thr Arg His Ile Arg Ile His Thr Gly Gln Lys Pro Phe 
        355                 360                 365             


Gln Cys Arg Ile Cys Met Arg Asn Phe Ser Arg Ser Asp His Leu Thr 
    370                 375                 380                 


Thr His Ile Arg Thr His Thr Gly Glu Lys Pro Phe Ala Cys Asp Ile 
385                 390                 395                 400 


Cys Gly Arg Lys Phe Ala Arg Ser Asp Glu Arg Lys Arg His Thr Lys 
                405                 410                 415     


Ile His Leu Arg Gln Lys Asp Lys Lys Ala Asp Lys Ser Val Val Ala 
            420                 425                 430         


Ser Ser Ala Thr Ser Ser Leu Ser Ser Tyr Pro Ser Pro Val Ala Thr 
        435                 440                 445             


Ser Tyr Pro Ser Pro Val Thr Thr Ser Tyr Pro Ser Pro Ala Thr Thr 
    450                 455                 460                 


Ser Tyr Pro Ser Pro Val Pro Thr Ser Phe Ser Ser Pro Gly Ser Ser 
465                 470                 475                 480 


Thr Tyr Pro Ser Pro Val His Ser Gly Phe Pro Ser Pro Ser Val Ala 
                485                 490                 495     


Thr Thr Tyr Ser Ser Val Pro Pro Ala Phe Pro Ala Gln Val Ser Ser 
            500                 505                 510         


Phe Pro Ser Ser Ala Val Thr Asn Ser Phe Ser Ala Ser Thr Gly Leu 
        515                 520                 525             


Ser Asp Met Thr Ala Thr Phe Ser Pro Arg Thr Ile Glu Ile Cys 
    530                 535                 540             


<210>  176
<211>  581
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Thr Ser Ala Val Val Asp Ser Gly Gly Thr Ile Leu Glu Leu Ser 
1               5                   10                  15      


Ser Asn Gly Val Glu Asn Gln Glu Glu Ser Glu Lys Val Ser Glu Tyr 
            20                  25                  30          


Pro Ala Val Ile Val Glu Pro Val Pro Ser Ala Arg Leu Glu Gln Gly 
        35                  40                  45              


Tyr Ala Ala Gln Val Leu Val Tyr Asp Asp Glu Thr Tyr Met Met Gln 
    50                  55                  60                  


Asp Val Ala Glu Glu Gln Glu Val Glu Thr Glu Asn Val Glu Thr Val 
65                  70                  75                  80  


Glu Ala Ser Val His Ser Ser Asn Ala His Cys Thr Asp Lys Thr Ile 
                85                  90                  95      


Glu Ala Ala Glu Ala Leu Leu His Met Glu Ser Pro Thr Cys Leu Arg 
            100                 105                 110         


Asp Ser Arg Ser Pro Glu Phe Ile His Ala Ala Met Arg Pro Asp Val 
        115                 120                 125             


Ile Thr Glu Thr Val Val Glu Val Ser Thr Glu Glu Ser Glu Pro Met 
    130                 135                 140                 


Asp Thr Ser Pro Ile Pro Thr Ser Pro Asp Ser His Glu Pro Met Lys 
145                 150                 155                 160 


Lys Lys Lys Val Gly Arg Lys Pro Lys Thr Gln Gln Ser Pro Ile Ser 
                165                 170                 175     


Asn Gly Ser Pro Glu Leu Gly Ile Lys Lys Lys Pro Arg Glu Gly Lys 
            180                 185                 190         


Gly Asn Thr Thr Tyr Leu Trp Glu Phe Leu Leu Asp Leu Leu Gln Asp 
        195                 200                 205             


Lys Asn Thr Cys Pro Arg Tyr Ile Lys Trp Thr Gln Arg Glu Lys Gly 
    210                 215                 220                 


Ile Phe Lys Leu Val Asp Ser Lys Ala Val Ser Lys Leu Trp Gly Lys 
225                 230                 235                 240 


His Lys Asn Lys Pro Asp Met Asn Tyr Glu Thr Met Gly Arg Ala Leu 
                245                 250                 255     


Arg Tyr Tyr Tyr Gln Arg Gly Ile Leu Ala Lys Val Glu Gly Gln Arg 
            260                 265                 270         


Leu Val Tyr Gln Phe Lys Asp Met Pro Lys Asn Ile Val Val Ile Asp 
        275                 280                 285             


Asp Asp Lys Ser Glu Thr Cys Asn Glu Asp Leu Ala Gly Thr Thr Asp 
    290                 295                 300                 


Glu Lys Ser Leu Glu Arg Val Ser Leu Ser Ala Glu Ser Leu Leu Lys 
305                 310                 315                 320 


Ala Ala Ser Ser Val Arg Ser Gly Lys Asn Ser Ser Pro Ile Asn Cys 
                325                 330                 335     


Ser Arg Ala Glu Lys Gly Val Ala Arg Val Val Asn Ile Thr Ser Pro 
            340                 345                 350         


Gly His Asp Ala Ser Ser Arg Ser Pro Thr Thr Thr Ala Ser Val Ser 
        355                 360                 365             


Ala Thr Ala Ala Pro Arg Thr Val Arg Val Ala Met Gln Val Pro Val 
    370                 375                 380                 


Val Met Thr Ser Leu Gly Gln Lys Ile Ser Thr Val Ala Val Gln Ser 
385                 390                 395                 400 


Val Asn Ala Gly Ala Pro Leu Ile Thr Ser Thr Ser Pro Thr Thr Ala 
                405                 410                 415     


Thr Ser Pro Lys Val Val Ile Gln Thr Ile Pro Thr Val Met Pro Ala 
            420                 425                 430         


Ser Thr Glu Asn Gly Asp Lys Ile Thr Met Gln Pro Ala Lys Ile Ile 
        435                 440                 445             


Thr Ile Pro Ala Thr Gln Leu Ala Gln Cys Gln Leu Gln Thr Lys Ser 
    450                 455                 460                 


Asn Leu Thr Gly Ser Gly Ser Ile Asn Ile Val Gly Thr Pro Leu Ala 
465                 470                 475                 480 


Val Arg Ala Leu Thr Pro Val Ser Ile Ala His Gly Thr Pro Val Met 
                485                 490                 495     


Arg Leu Ser Met Pro Thr Gln Gln Ala Ser Gly Gln Thr Pro Pro Arg 
            500                 505                 510         


Val Ile Ser Ala Val Ile Lys Gly Pro Glu Val Lys Ser Glu Ala Val 
        515                 520                 525             


Ala Lys Lys Gln Glu His Asp Val Lys Thr Leu Gln Leu Val Glu Glu 
    530                 535                 540                 


Lys Pro Ala Asp Gly Asn Lys Thr Val Thr His Val Val Val Val Ser 
545                 550                 555                 560 


Ala Pro Ser Ala Ile Ala Leu Pro Val Thr Met Lys Thr Glu Gly Leu 
                565                 570                 575     


Val Thr Cys Glu Lys 
            580     


<210>  177
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Thr Met Thr Leu His Thr Lys Ala Ser Gly Met Ala Leu Leu His 
1               5                   10                  15      


Gln Ile Gln Gly Asn Glu Leu Glu Pro Leu Asn Arg Pro Gln Leu Lys 
            20                  25                  30          


Ile Pro Leu Glu Arg Pro Leu Gly Glu Val Tyr Leu Asp Ser Ser Lys 
        35                  40                  45              


Pro Ala Val Tyr Asn Tyr Pro Glu Gly Ala Ala Tyr Glu Phe Asn Ala 
    50                  55                  60                  


Ala Ala Ala Ala Asn Ala Gln Val Tyr Gly Gln Thr Gly Leu Pro Tyr 
65                  70                  75                  80  


Gly Pro Gly Ser Glu Ala Ala Ala Phe Gly Ser Asn Gly Leu Gly Gly 
                85                  90                  95      


Phe Pro Pro Leu Asn Ser Val Ser Pro Ser Pro Leu Met Leu Leu His 
            100                 105                 110         


Pro Pro Pro Gln Leu Ser Pro Phe Leu Gln Pro His Gly Gln Gln Val 
        115                 120                 125             


Pro Tyr Tyr Leu Glu Asn Glu Pro Ser Gly Tyr Thr Val Arg Glu Ala 
    130                 135                 140                 


Gly Pro Pro Ala Phe Tyr Arg Pro Asn Ser Asp Asn Arg Arg Gln Gly 
145                 150                 155                 160 


Gly Arg Glu Arg Leu Ala Ser Thr Asn Asp Lys Gly Ser Met Ala Met 
                165                 170                 175     


Glu Ser Ala Lys Glu Thr Arg Tyr Cys Ala Val Cys Asn Asp Tyr Ala 
            180                 185                 190         


Ser Gly Tyr His Tyr Gly Val Trp Ser Cys Glu Gly Cys Lys Ala Phe 
        195                 200                 205             


Phe Lys Arg Ser Ile Gln Gly His Asn Asp Tyr Met Cys Pro Ala Thr 
    210                 215                 220                 


Asn Gln Cys Thr Ile Asp Lys Asn Arg Arg Lys Ser Cys Gln Ala Cys 
225                 230                 235                 240 


Arg Leu Arg Lys Cys Tyr Glu Val Gly Met Met Lys Gly Gly Ile Arg 
                245                 250                 255     


Lys Asp Arg Arg Gly Gly Arg Met Leu Lys His Lys Arg Gln Arg Asp 
            260                 265                 270         


Asp Gly Glu Gly Arg Gly Glu Val Gly Ser Ala Gly Asp Met Arg Ala 
        275                 280                 285             


Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn 
    290                 295                 300                 


Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu 
305                 310                 315                 320 


Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro 
                325                 330                 335     


Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg 
            340                 345                 350         


Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val 
        355                 360                 365             


Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu 
    370                 375                 380                 


Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Gly 
385                 390                 395                 400 


Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys 
                405                 410                 415     


Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser 
            420                 425                 430         


Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu 
        435                 440                 445             


Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser 
    450                 455                 460                 


Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp 
465                 470                 475                 480 


Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr 
                485                 490                 495     


Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser 
            500                 505                 510         


His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met 
        515                 520                 525             


Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Met Leu 
    530                 535                 540                 


Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val 
545                 550                 555                 560 


Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser 
                565                 570                 575     


His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro 
            580                 585                 590         


Ala Thr Val 
        595 


<210>  178
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Ala Gly Gly Val Asp Gly Pro Ile Gly Ile Pro Phe Pro Asp His 
1               5                   10                  15      


Ser Ser Asp Ile Leu Ser Gly Leu Asn Glu Gln Arg Thr Gln Gly Leu 
            20                  25                  30          


Leu Cys Asp Val Val Ile Leu Val Glu Gly Arg Glu Phe Pro Thr His 
        35                  40                  45              


Arg Ser Val Leu Ala Ala Cys Ser Gln Tyr Phe Lys Lys Leu Phe Thr 
    50                  55                  60                  


Ser Gly Ala Val Val Asp Gln Gln Asn Val Tyr Glu Ile Asp Phe Val 
65                  70                  75                  80  


Ser Ala Glu Ala Leu Thr Ala Leu Met Asp Phe Ala Tyr Thr Ala Thr 
                85                  90                  95      


Leu Thr Val Ser Thr Ala Asn Val Gly Asp Ile Leu Ser Ala Ala Arg 
            100                 105                 110         


Leu Leu Glu Ile Pro Ala Val Ser His Val Cys Ala Asp Leu Leu Asp 
        115                 120                 125             


Arg Gln Ile Leu Ala Ala Asp Ala Gly Ala Asp Ala Gly Gln Leu Asp 
    130                 135                 140                 


Leu Val Asp Gln Ile Asp Gln Arg Asn Leu Leu Arg Ala Lys Glu Tyr 
145                 150                 155                 160 


Leu Glu Phe Phe Gln Ser Asn Pro Met Asn Ser Leu Pro Pro Ala Ala 
                165                 170                 175     


Ala Ala Ala Ala Ala Ser Phe Pro Trp Ser Ala Phe Gly Ala Ser Asp 
            180                 185                 190         


Asp Asp Leu Asp Ala Thr Lys Glu Ala Val Ala Ala Ala Val Ala Ala 
        195                 200                 205             


Val Ala Ala Gly Asp Cys Asn Gly Leu Asp Phe Tyr Gly Pro Gly Pro 
    210                 215                 220                 


Pro Ala Glu Arg Pro Pro Thr Gly Asp Gly Asp Glu Gly Asp Ser Asn 
225                 230                 235                 240 


Pro Gly Leu Trp Pro Glu Arg Asp Glu Asp Ala Pro Thr Gly Gly Leu 
                245                 250                 255     


Phe Pro Pro Pro Val Ala Pro Pro Ala Ala Thr Gln Asn Gly His Tyr 
            260                 265                 270         


Gly Arg Gly Gly Glu Glu Glu Ala Ala Ser Leu Ser Glu Ala Ala Pro 
        275                 280                 285             


Glu Pro Gly Asp Ser Pro Gly Phe Leu Ser Gly Ala Ala Glu Gly Glu 
    290                 295                 300                 


Asp Gly Asp Gly Pro Asp Val Asp Gly Leu Ala Ala Ser Thr Leu Leu 
305                 310                 315                 320 


Gln Gln Met Met Ser Ser Val Gly Arg Ala Gly Ala Ala Ala Gly Asp 
                325                 330                 335     


Ser Asp Glu Glu Ser Arg Ala Asp Asp Lys Gly Val Met Asp Tyr Tyr 
            340                 345                 350         


Leu Lys Tyr Phe Ser Gly Ala His Asp Gly Asp Val Tyr Pro Ala Trp 
        355                 360                 365             


Ser Gln Lys Val Glu Lys Lys Ile Arg Ala Lys Ala Phe Gln Lys Cys 
    370                 375                 380                 


Pro Ile Cys Glu Lys Val Ile Gln Gly Ala Gly Lys Leu Pro Arg His 
385                 390                 395                 400 


Ile Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Ile Cys Lys 
                405                 410                 415     


Val Arg Phe Thr Arg Gln Asp Lys Leu Lys Val His Met Arg Lys His 
            420                 425                 430         


Thr Gly Glu Lys Pro Tyr Leu Cys Gln Gln Cys Gly Ala Ala Phe Ala 
        435                 440                 445             


His Asn Tyr Asp Leu Lys Asn His Met Arg Val His Thr Gly Leu Arg 
    450                 455                 460                 


Pro Tyr Gln Cys Asp Ser Cys Cys Lys Thr Phe Val Arg Ser Asp His 
465                 470                 475                 480 


Leu His Arg His Leu Lys Lys Asp Gly Cys Asn Gly Val Pro Ser Arg 
                485                 490                 495     


Arg Gly Arg Lys Pro Arg Val Arg Gly Gly Ala Pro Asp Pro Ser Pro 
            500                 505                 510         


Gly Ala Thr Ala Thr Pro Gly Ala Pro Ala Gln Pro Ser Ser Pro Asp 
        515                 520                 525             


Ala Arg Arg Asn Gly Gln Glu Lys His Phe Lys Asp Glu Asp Glu Asp 
    530                 535                 540                 


Glu Asp Val Ala Ser Pro Asp Gly Leu Gly Arg Leu Asn Val Ala Gly 
545                 550                 555                 560 


Ala Gly Gly Gly Gly Asp Ser Gly Gly Gly Pro Gly Ala Ala Thr Asp 
                565                 570                 575     


Gly Asn Phe Thr Ala Gly Leu Ala 
            580                 


<210>  179
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Ala Glu Lys Phe Asp Cys His Tyr Cys Arg Asp Pro Leu Gln Gly 
1               5                   10                  15      


Lys Lys Tyr Val Gln Lys Asp Gly His His Cys Cys Leu Lys Cys Phe 
            20                  25                  30          


Asp Lys Phe Cys Ala Asn Thr Cys Val Glu Cys Arg Lys Pro Ile Gly 
        35                  40                  45              


Ala Asp Ser Lys Glu Val His Tyr Lys Asn Arg Phe Trp His Asp Thr 
    50                  55                  60                  


Cys Phe Arg Cys Ala Lys Cys Leu His Pro Leu Ala Asn Glu Thr Phe 
65                  70                  75                  80  


Val Ala Lys Asp Asn Lys Ile Leu Cys Asn Lys Cys Thr Thr Arg Glu 
                85                  90                  95      


Asp Ser Pro Lys Cys Lys Gly Cys Phe Lys Ala Ile Val Ala Gly Asp 
            100                 105                 110         


Gln Asn Val Glu Tyr Lys Gly Thr Val Trp His Lys Asp Cys Phe Thr 
        115                 120                 125             


Cys Ser Asn Cys Lys Gln Val Ile Gly Thr Gly Ser Phe Phe Pro Lys 
    130                 135                 140                 


Gly Glu Asp Phe Tyr Cys Val Thr Cys His Glu Thr Lys Phe Ala Lys 
145                 150                 155                 160 


His Cys Val Lys Cys Asn Lys Ala Ile Thr Ser Gly Gly Ile Thr Tyr 
                165                 170                 175     


Gln Asp Gln Pro Trp His Ala Asp Cys Phe Val Cys Val Thr Cys Ser 
            180                 185                 190         


Lys Lys Leu Ala Gly Gln Arg Phe Thr Ala Val Glu Asp Gln Tyr Tyr 
        195                 200                 205             


Cys Val Asp Cys Tyr Lys Asn Phe Val Ala Lys Lys Cys Ala Gly Cys 
    210                 215                 220                 


Lys Asn Pro Ile Thr Gly Lys Arg Thr Val Ser Arg Val Ser His Pro 
225                 230                 235                 240 


Val Ser Lys Ala Arg Lys Pro Pro Val Cys His Gly Lys Arg Leu Pro 
                245                 250                 255     


Leu Thr Leu Phe Pro Ser Ala Asn Leu Arg Gly Arg His Pro Gly Gly 
            260                 265                 270         


Glu Arg Thr Cys Pro Ser Trp Val Val Val Leu Tyr Arg Lys Asn Arg 
        275                 280                 285             


Ser Leu Ala Ala Pro Arg Gly Pro Gly Leu Val Lys Ala Pro Val Trp 
    290                 295                 300                 


Trp Pro Met Lys Asp Asn Pro Gly Thr Thr Thr Ala Ser Thr Ala Lys 
305                 310                 315                 320 


Asn Ala Pro 
            


<210>  180
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  181
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  181

Met Thr Lys Arg Glu Ala Glu Glu Leu Ile Glu Ile Glu Ile Asp Gly 
1               5                   10                  15      


Thr Glu Lys Ala Glu Cys Thr Glu Glu Ser Ile Val Glu Gln Thr Tyr 
            20                  25                  30          


Ala Pro Ala Glu Cys Val Ser Gln Ala Ile Asp Ile Asn Glu Pro Ile 
        35                  40                  45              


Gly Asn Leu Lys Lys Leu Leu Glu Pro Arg Leu Gln Cys Ser Leu Asp 
    50                  55                  60                  


Ala His Glu Ile Cys Leu Gln Asp Ile Gln Leu Asp Pro Glu Arg Ser 
65                  70                  75                  80  


Leu Phe Asp Gln Gly Val Lys Thr Asp Gly Thr Val Gln Leu Ser Val 
                85                  90                  95      


Gln Val Ile Ser Tyr Gln Gly Ile Glu Pro Lys Leu Asn Ile Leu Glu 
            100                 105                 110         


Ile Val Lys Pro Ala Asp Thr Val Glu Val Val Ile Asp Pro Asp Ala 
        115                 120                 125             


His His Ala Glu Ser Glu Ala His Leu Val Glu Glu Ala Gln Val Ile 
    130                 135                 140                 


Thr Leu Asp Gly Thr Lys His Ile Thr Thr Ile Ser Asp Glu Thr Ser 
145                 150                 155                 160 


Glu Gln Val Thr Arg Trp Ala Ala Ala Leu Glu Gly Tyr Arg Lys Glu 
                165                 170                 175     


Gln Glu Arg Leu Gly Ile Pro Tyr Asp Pro Ile Gln Trp Ser Thr Asp 
            180                 185                 190         


Gln Val Leu His Trp Val Val Trp Val Met Lys Glu Phe Ser Met Thr 
        195                 200                 205             


Asp Ile Asp Leu Thr Thr Leu Asn Ile Ser Gly Arg Glu Leu Cys Ser 
    210                 215                 220                 


Leu Asn Gln Glu Asp Phe Phe Gln Arg Val Pro Arg Gly Glu Ile Leu 
225                 230                 235                 240 


Trp Ser His Leu Glu Leu Leu Arg Lys Tyr Val Leu Ala Ser Gln Glu 
                245                 250                 255     


Gln Gln Met Asn Glu Ile Val Thr Ile Asp Gln Pro Val Gln Ile Ile 
            260                 265                 270         


Pro Ala Ser Val Gln Ser Ala Thr Pro Thr Thr Ile Lys Val Ile Asn 
        275                 280                 285             


Ser Ser Ala Lys Ala Ala Lys Val Gln Arg Ala Pro Arg Ile Ser Gly 
    290                 295                 300                 


Glu Asp Arg Ser Ser Pro Gly Asn Arg Thr Gly Asn Asn Gly Gln Ile 
305                 310                 315                 320 


Gln Leu Trp Gln Phe Leu Leu Glu Leu Leu Thr Asp Lys Asp Ala Arg 
                325                 330                 335     


Asp Cys Ile Ser Trp Val Gly Asp Glu Gly Glu Phe Lys Leu Asn Gln 
            340                 345                 350         


Pro Glu Leu Val Ala Gln Lys Trp Gly Gln Arg Lys Asn Lys Pro Thr 
        355                 360                 365             


Met Asn Tyr Glu Lys Leu Ser Arg Ala Leu Arg Tyr Tyr Tyr Asp Gly 
    370                 375                 380                 


Asp Met Ile Cys Lys Val Gln Gly Lys Arg Phe Val Tyr Lys Phe Val 
385                 390                 395                 400 


Cys Asp Leu Lys Thr Leu Ile Gly Tyr Ser Ala Ala Glu Leu Asn Arg 
                405                 410                 415     


Leu Val Thr Glu Cys Glu Gln Lys Lys Leu Ala Lys Met Gln Leu His 
            420                 425                 430         


Gly Ile Ala Gln Pro Val Thr Ala Val Ala Leu Ala Thr Ala Ser Leu 
        435                 440                 445             


Gln Thr Glu Lys Asp Asn 
    450                 


<210>  182
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Glu Lys Met Ser Arg Pro Leu Pro Leu Asn Pro Thr Phe Ile Pro 
1               5                   10                  15      


Pro Pro Tyr Gly Val Leu Arg Ser Leu Leu Glu Asn Pro Leu Lys Leu 
            20                  25                  30          


Pro Leu His His Glu Asp Ala Phe Ser Lys Asp Lys Asp Lys Glu Lys 
        35                  40                  45              


Lys Leu Asp Asp Glu Ser Asn Ser Pro Thr Val Pro Gln Ser Ala Phe 
    50                  55                  60                  


Leu Gly Pro Thr Leu Trp Asp Lys Thr Leu Pro Tyr Asp Gly Asp Thr 
65                  70                  75                  80  


Phe Gln Leu Glu Tyr Met Asp Leu Glu Glu Phe Leu Ser Glu Asn Gly 
                85                  90                  95      


Ile Pro Pro Ser Pro Ser Gln His Asp His Ser Pro His Pro Pro Gly 
            100                 105                 110         


Leu Gln Pro Ala Ser Ser Ala Ala Pro Ser Val Met Asp Leu Ser Ser 
        115                 120                 125             


Arg Ala Ser Ala Pro Leu His Pro Gly Ile Pro Ser Pro Asn Cys Met 
    130                 135                 140                 


Gln Ser Pro Ile Arg Pro Gly Gln Leu Leu Pro Ala Asn Arg Asn Thr 
145                 150                 155                 160 


Pro Ser Pro Ile Asp Pro Asp Thr Ile Gln Val Pro Val Gly Tyr Glu 
                165                 170                 175     


Pro Asp Pro Ala Asp Leu Ala Leu Ser Ser Ile Pro Gly Gln Glu Met 
            180                 185                 190         


Phe Asp Pro Arg Lys Arg Lys Phe Ser Glu Glu Glu Leu Lys Pro Gln 
        195                 200                 205             


Pro Met Ile Lys Lys Ala Arg Lys Val Phe Ile Pro Asp Asp Leu Lys 
    210                 215                 220                 


Asp Asp Lys Tyr Trp Ala Arg Arg Arg Lys Asn Asn Met Ala Ala Lys 
225                 230                 235                 240 


Arg Ser Arg Asp Ala Arg Arg Leu Lys Glu Asn Gln Ile Ala Ile Arg 
                245                 250                 255     


Ala Ser Phe Leu Glu Lys Glu Asn Ser Ala Leu Arg Gln Glu Val Ala 
            260                 265                 270         


Asp Leu Arg Lys Glu Leu Gly Lys Cys Lys Asn Ile Leu Ala Lys Tyr 
        275                 280                 285             


Glu Ala Arg His Gly Pro Leu 
    290                 295 


<210>  183
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  183

Met Leu Ile Phe Leu Gly Cys Tyr Arg Arg Arg Leu Glu Glu Arg Ala 
1               5                   10                  15      


Gly Thr Met Ser Ala Glu Thr Ala Ser Gly Pro Thr Glu Asp Gln Val 
            20                  25                  30          


Glu Ile Leu Glu Tyr Asn Phe Asn Lys Val Asp Lys His Pro Asp Ser 
        35                  40                  45              


Thr Thr Leu Cys Leu Ile Ala Ala Glu Ala Gly Leu Ser Glu Glu Glu 
    50                  55                  60                  


Thr Gln Gly Ser Asp Leu Ile Ser Arg Ser Lys Ile Trp His Pro Glu 
65                  70                  75                  80  


Ser Ser Pro Gln Arg Glu Gly Tyr Pro His Asp Ser Leu Pro Cys Leu 
                85                  90                  95      


Ala Phe Asp Tyr Phe Ser Leu Leu Pro Pro Gln Cys Lys Glu Met Val 
            100                 105                 110         


<210>  184
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Lys Val Ala Ser Gly Ser Thr Ala Thr Ala Ala Ala Gly Pro Ser 
1               5                   10                  15      


Cys Ala Leu Lys Ala Gly Lys Thr Ala Ser Gly Ala Gly Glu Val Val 
            20                  25                  30          


Arg Cys Leu Ser Glu Gln Ser Val Ala Ile Ser Arg Cys Ala Gly Gly 
        35                  40                  45              


Ala Gly Ala Arg Leu Pro Ala Leu Leu Asp Glu Gln Gln Val Asn Val 
    50                  55                  60                  


Leu Leu Tyr Asp Met Asn Gly Cys Tyr Ser Arg Leu Lys Glu Leu Val 
65                  70                  75                  80  


Pro Thr Leu Pro Gln Asn Arg Lys Val Ser Lys Val Glu Ile Leu Gln 
                85                  90                  95      


His Val Ile Asp Tyr Ile Arg Asp Leu Gln Leu Glu Leu Asn Ser Glu 
            100                 105                 110         


Ser Glu Val Gly Thr Pro Gly Gly Arg Gly Leu Pro Val Arg Ala Pro 
        115                 120                 125             


Leu Ser Thr Leu Asn Gly Glu Ile Ser Ala Leu Thr Ala Glu Ala Ala 
    130                 135                 140                 


Cys Val Pro Ala Asp Asp Arg Ile Leu Cys Arg 
145                 150                 155 


<210>  185
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  185

Met Lys Ala Phe Ser Pro Val Arg Ser Val Arg Lys Asn Ser Leu Ser 
1               5                   10                  15      


Asp His Ser Leu Gly Ile Ser Arg Ser Lys Thr Pro Val Asp Asp Pro 
            20                  25                  30          


Met Ser Leu Leu Tyr Asn Met Asn Asp Cys Tyr Ser Lys Leu Lys Glu 
        35                  40                  45              


Leu Val Pro Ser Ile Pro Gln Asn Lys Lys Val Ser Lys Met Glu Ile 
    50                  55                  60                  


Leu Gln His Val Ile Asp Tyr Ile Leu Asp Leu Gln Ile Ala Leu Asp 
65                  70                  75                  80  


Ser His Pro Thr Ile Val Ser Leu His His Gln Arg Pro Gly Gln Asn 
                85                  90                  95      


Gln Ala Ser Arg Thr Pro Leu Thr Thr Leu Asn Thr Asp Ile Ser Ile 
            100                 105                 110         


Leu Ser Leu Gln Ala Ser Glu Phe Pro Ser Glu Leu Met Ser Asn Asp 
        115                 120                 125             


Ser Lys Ala Leu Cys Gly 
    130                 


<210>  186
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Pro Ile Thr Arg Met Arg Met Arg Pro Trp Leu Glu Met Gln Ile 
1               5                   10                  15      


Asn Ser Asn Gln Ile Pro Gly Leu Ile Trp Ile Asn Lys Glu Glu Met 
            20                  25                  30          


Ile Phe Gln Ile Pro Trp Lys His Ala Ala Lys His Gly Trp Asp Ile 
        35                  40                  45              


Asn Lys Asp Ala Cys Leu Phe Arg Ser Trp Ala Ile His Thr Gly Arg 
    50                  55                  60                  


Tyr Lys Ala Gly Glu Lys Glu Pro Asp Pro Lys Thr Trp Lys Ala Asn 
65                  70                  75                  80  


Phe Arg Cys Ala Met Asn Ser Leu Pro Asp Ile Glu Glu Val Lys Asp 
                85                  90                  95      


Gln Ser Arg Asn Lys Gly Ser Ser Ala Val Arg Val Tyr Arg Met Leu 
            100                 105                 110         


Pro Pro Leu Thr Lys Asn Gln Arg Lys Glu Arg Lys Ser Lys Ser Ser 
        115                 120                 125             


Arg Asp Ala Lys Ser Lys Ala Lys Arg Lys Ser Cys Gly Asp Ser Ser 
    130                 135                 140                 


Pro Asp Thr Phe Ser Asp Gly Leu Ser Ser Ser Thr Leu Pro Asp Asp 
145                 150                 155                 160 


His Ser Ser Tyr Thr Val Pro Gly Tyr Met Gln Asp Leu Glu Val Glu 
                165                 170                 175     


Gln Ala Leu Thr Pro Ala Leu Ser Pro Cys Ala Val Ser Ser Thr Leu 
            180                 185                 190         


Pro Asp Trp His Ile Pro Val Glu Val Val Pro Asp Ser Thr Ser Asp 
        195                 200                 205             


Leu Tyr Asn Phe Gln Val Ser Pro Met Pro Ser Thr Ser Glu Ala Thr 
    210                 215                 220                 


Thr Asp Glu Asp Glu Glu Gly Lys Leu Pro Glu Asp Ile Met Lys Leu 
225                 230                 235                 240 


Leu Glu Gln Ser Glu Trp Gln Pro Thr Asn Val Asp Gly Lys Gly Tyr 
                245                 250                 255     


Leu Leu Asn Glu Pro Gly Val Gln Pro Thr Ser Val Tyr Gly Asp Phe 
            260                 265                 270         


Ser Cys Lys Glu Glu Pro Glu Ile Asp Ser Pro Gly Gly Asp Ile Gly 
        275                 280                 285             


Leu Ser Leu Gln Arg Val Phe Thr Asp Leu Lys Asn Met Asp Ala Thr 
    290                 295                 300                 


Trp Leu Asp Ser Leu Leu Thr Pro Val Arg Leu Pro Ser Ile Gln Ala 
305                 310                 315                 320 


Ile Pro Cys Ala Pro 
                325 


<210>  187
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  187

Met Asn Ile His Met Lys Arg Lys Thr Ile Lys Asn Ile Asn Thr Phe 
1               5                   10                  15      


Glu Asn Arg Met Leu Met Leu Asp Gly Met Pro Ala Val Arg Val Lys 
            20                  25                  30          


Thr Glu Leu Leu Glu Ser Glu Gln Gly Ser Pro Asn Val His Asn Tyr 
        35                  40                  45              


Pro Asp Met Glu Ala Val Pro Leu Leu Leu Asn Asn Val Lys Gly Glu 
    50                  55                  60                  


Pro Pro Glu Asp Ser Leu Ser Val Asp His Phe Gln Thr Gln Thr Glu 
65                  70                  75                  80  


Pro Val Asp Leu Ser Ile Asn Lys Ala Arg Thr Ser Pro Thr Ala Val 
                85                  90                  95      


Ser Ser Ser Pro Val Ser Met Thr Ala Ser Ala Ser Ser Pro Ser Ser 
            100                 105                 110         


Thr Ser Thr Ser Ser Ser Ser Ser Ser Arg Leu Ala Ser Ser Pro Thr 
        115                 120                 125             


Val Ile Thr Ser Val Ser Ser Ala Ser Ser Ser Ser Thr Val Leu Thr 
    130                 135                 140                 


Pro Gly Pro Leu Val Ala Ser Ala Ser Gly Val Gly Gly Gln Gln Phe 
145                 150                 155                 160 


Leu His Ile Ile His Pro Val Pro Pro Ser Ser Pro Met Asn Leu Gln 
                165                 170                 175     


Ser Asn Lys Leu Ser His Val His Arg Ile Pro Val Val Val Gln Ser 
            180                 185                 190         


Val Pro Val Val Tyr Thr Ala Val Arg Ser Pro Gly Asn Val Asn Asn 
        195                 200                 205             


Thr Ile Val Val Pro Leu Leu Glu Asp Gly Arg Gly His Gly Lys Ala 
    210                 215                 220                 


Gln Met Asp Pro Arg Gly Leu Ser Pro Arg Gln Ser Lys Ser Asp Ser 
225                 230                 235                 240 


Asp Asp Asp Asp Leu Pro Asn Val Thr Leu Asp Ser Val Asn Glu Thr 
                245                 250                 255     


Gly Ser Thr Ala Leu Ser Ile Ala Arg Ala Val Gln Glu Val His Pro 
            260                 265                 270         


Ser Pro Val Ser Arg Val Arg Gly Asn Arg Met Asn Asn Gln Lys Phe 
        275                 280                 285             


Pro Cys Ser Ile Ser Pro Phe Ser Ile Glu Ser Thr Arg Arg Gln Arg 
    290                 295                 300                 


Arg Ser Glu Ser Pro Asp Ser Arg Lys Arg Arg Ile His Arg Cys Asp 
305                 310                 315                 320 


Phe Glu Gly Cys Asn Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala 
                325                 330                 335     


His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Thr Trp Glu 
            340                 345                 350         


Gly Cys Thr Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr 
        355                 360                 365             


Arg Lys His Thr Gly Val Lys Pro Phe Lys Cys Ala Asp Cys Asp Arg 
    370                 375                 380                 


Ser Phe Ser Arg Ser Asp His Leu Ala Leu His Arg Arg Arg His Met 
385                 390                 395                 400 


Leu Val 
        


<210>  188
<211>  411
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Ser Val Gly Cys Ala Cys Pro Gly Cys Ser Ser Lys Ser Phe Lys 
1               5                   10                  15      


Leu Tyr Ser Pro Lys Glu Pro Pro Asn Gly Asn Ala Phe Pro Pro Phe 
            20                  25                  30          


His Pro Gly Thr Met Leu Asp Arg Asp Val Gly Pro Thr Pro Met Tyr 
        35                  40                  45              


Pro Pro Thr Tyr Leu Glu Pro Gly Ile Gly Arg His Thr Pro Tyr Gly 
    50                  55                  60                  


Asn Gln Thr Asp Tyr Arg Ile Phe Glu Leu Asn Lys Arg Leu Gln Asn 
65                  70                  75                  80  


Trp Thr Glu Glu Cys Asp Asn Leu Trp Trp Asp Ala Phe Thr Thr Glu 
                85                  90                  95      


Phe Phe Glu Asp Asp Ala Met Leu Thr Ile Thr Phe Cys Leu Glu Asp 
            100                 105                 110         


Gly Pro Lys Arg Tyr Thr Ile Gly Arg Thr Leu Ile Pro Arg Tyr Phe 
        115                 120                 125             


Arg Ser Ile Phe Glu Gly Gly Ala Thr Glu Leu Tyr Tyr Val Leu Lys 
    130                 135                 140                 


His Pro Lys Glu Ala Phe His Ser Asn Phe Val Ser Leu Asp Cys Asp 
145                 150                 155                 160 


Gln Gly Ser Met Val Thr Gln His Gly Lys Pro Met Phe Thr Gln Val 
                165                 170                 175     


Cys Val Glu Gly Arg Leu Tyr Leu Glu Phe Met Phe Asp Asp Met Met 
            180                 185                 190         


Arg Ile Lys Thr Trp His Phe Ser Ile Arg Gln His Arg Glu Leu Ile 
        195                 200                 205             


Pro Arg Ser Ile Leu Ala Met His Ala Gln Asp Pro Gln Met Leu Asp 
    210                 215                 220                 


Gln Leu Ser Lys Asn Ile Thr Arg Cys Gly Leu Ser Asn Ser Thr Leu 
225                 230                 235                 240 


Asn Tyr Leu Arg Leu Cys Val Ile Leu Glu Pro Met Gln Glu Leu Met 
                245                 250                 255     


Ser Arg His Lys Thr Tyr Ser Leu Ser Pro Arg Asp Cys Leu Lys Thr 
            260                 265                 270         


Cys Leu Phe Gln Lys Trp Gln Arg Met Val Ala Pro Pro Ala Glu Pro 
        275                 280                 285             


Thr Arg Gln Gln Pro Ser Lys Arg Arg Lys Arg Lys Met Ser Gly Gly 
    290                 295                 300                 


Ser Thr Met Ser Ser Gly Gly Gly Asn Thr Asn Asn Ser Asn Ser Lys 
305                 310                 315                 320 


Lys Lys Ser Pro Ala Ser Thr Phe Ala Leu Ser Ser Gln Val Pro Asp 
                325                 330                 335     


Val Met Val Val Gly Glu Pro Thr Leu Met Gly Gly Glu Phe Gly Asp 
            340                 345                 350         


Glu Asp Glu Arg Leu Ile Thr Arg Leu Glu Asn Thr Gln Phe Asp Ala 
        355                 360                 365             


Ala Asn Gly Ile Asp Asp Glu Asp Ser Phe Asn Asn Ser Pro Ala Leu 
    370                 375                 380                 


Gly Ala Asn Ser Pro Trp Asn Ser Lys Pro Pro Ser Ser Gln Glu Ser 
385                 390                 395                 400 


Lys Ser Glu Asn Pro Thr Ser Gln Ala Ser Gln 
                405                 410     


<210>  189
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  189

Met Val His Cys Ala Gly Cys Lys Arg Pro Ile Leu Asp Arg Phe Leu 
1               5                   10                  15      


Leu Asn Val Leu Asp Arg Ala Trp His Val Lys Cys Val Gln Cys Cys 
            20                  25                  30          


Glu Cys Lys Cys Asn Leu Thr Glu Lys Cys Phe Ser Arg Glu Gly Lys 
        35                  40                  45              


Leu Tyr Cys Lys Asn Asp Phe Phe Arg Cys Phe Gly Thr Lys Cys Ala 
    50                  55                  60                  


Gly Cys Ala Gln Gly Ile Ser Pro Ser Asp Leu Val Arg Arg Ala Arg 
65                  70                  75                  80  


Ser Lys Val Phe His Leu Asn Cys Phe Thr Cys Met Met Cys Asn Lys 
                85                  90                  95      


Gln Leu Ser Thr Gly Glu Glu Leu Tyr Ile Ile Asp Glu Asn Lys Phe 
            100                 105                 110         


Val Cys Lys Glu Asp Tyr Leu Ser Asn Ser Ser Val Ala Lys Glu Asn 
        115                 120                 125             


Ser Leu His Ser Ala Thr Thr Gly Ser Asp Pro Ser Leu Ser Pro Asp 
    130                 135                 140                 


Ser Gln Asp Pro Ser Gln Asp Asp Ala Lys Asp Ser Glu Ser Ala Asn 
145                 150                 155                 160 


Val Ser Asp Lys Glu Ala Gly Ser Asn Glu Asn Asp Asp Gln Asn Leu 
                165                 170                 175     


Gly Ala Lys Arg Arg Gly Pro Arg Thr Thr Ile Lys Ala Lys Gln Leu 
            180                 185                 190         


Glu Thr Leu Lys Ala Ala Phe Ala Ala Thr Pro Lys Pro Thr Arg His 
        195                 200                 205             


Ile Arg Glu Gln Leu Ala Gln Glu Thr Gly Leu Asn Met Arg Val Ile 
    210                 215                 220                 


Gln Val Trp Phe Gln Asn Arg Arg Ser Lys Glu Arg Arg Met Lys Gln 
225                 230                 235                 240 


Leu Ser Ala Leu Gly Ala Arg Arg His Ala Phe Phe Arg Ser Pro Arg 
                245                 250                 255     


Arg Met Arg Pro Leu Val Asp Arg Leu Glu Pro Gly Glu Leu Ile Pro 
            260                 265                 270         


Asn Gly Pro Phe Ser Phe Tyr Gly Asp Tyr Gln Ser Glu Tyr Tyr Gly 
        275                 280                 285             


Pro Gly Gly Asn Tyr Asp Phe Phe Pro Gln Gly Pro Pro Ser Ser Gln 
    290                 295                 300                 


Ala Gln Thr Pro Val Asp Leu Pro Phe Val Pro Ser Ser Gly Pro Ser 
305                 310                 315                 320 


Gly Thr Pro Leu Gly Gly Leu Glu His Pro Leu Pro Gly His His Pro 
                325                 330                 335     


Ser Ser Glu Ala Gln Arg Phe Thr Asp Ile Leu Ala His Pro Pro Gly 
            340                 345                 350         


Asp Ser Pro Ser Pro Glu Pro Ser Leu Pro Gly Pro Leu His Ser Met 
        355                 360                 365             


Ser Ala Glu Val Phe Gly Pro Ser Pro Pro Phe Ser Ser Leu Ser Val 
    370                 375                 380                 


Asn Gly Gly Ala Ser Tyr Gly Asn His Leu Ser His Pro Pro Glu Met 
385                 390                 395                 400 


Asn Glu Ala Ala Val Trp 
                405     


<210>  190
<211>  260
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Ala Gln Ala Ala Leu Glu Pro Gly Glu Lys Pro Tyr Ala Cys Pro 
1               5                   10                  15      


Glu Cys Gly Lys Ser Phe Ser Thr Ser Gly Ser Leu Val Arg His Gln 
            20                  25                  30          


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
        35                  40                  45              


Ser Phe Ser Arg Asn Asp Ala Leu Thr Glu His Gln Arg Thr His Thr 
    50                  55                  60                  


Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Ser 
65                  70                  75                  80  


Lys Lys His Leu Ala Glu His Gln Arg Thr His Thr Gly Glu Lys Pro 
                85                  90                  95      


Tyr Ala Cys Pro Glu Cys Gly Lys Ser Phe Ser Thr Ser Gly Glu Leu 
            100                 105                 110         


Val Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro 
        115                 120                 125             


Glu Cys Gly Lys Ser Phe Ser Arg Ser Asp Lys Leu Val Arg His Gln 
    130                 135                 140                 


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys 
145                 150                 155                 160 


Ser Phe Ser Arg Ser Asp His Leu Thr Glu His Gln Arg Thr His Thr 
                165                 170                 175     


Gly Lys Lys Thr Ser Gly Gln Ala Gly Gln Ala Ser Pro Lys Lys Lys 
            180                 185                 190         


Arg Lys Val Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
        195                 200                 205             


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
    210                 215                 220                 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
225                 230                 235                 240 


Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Tyr Pro Tyr Asp Val Pro 
                245                 250                 255     


Asp Tyr Ala Ser 
            260 


<210>  191
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  191

Met Lys Leu Leu Ser Ser Ile Glu Gln Ala Cys Asp Ile Cys Arg Leu 
1               5                   10                  15      


Lys Lys Leu Lys Cys Ser Lys Glu Lys Pro Lys Cys Ala Lys Cys Leu 
            20                  25                  30          


Lys Asn Asn Trp Glu Cys Arg Tyr Ser Pro Lys Thr Lys Arg Ser Pro 
        35                  40                  45              


Leu Thr Arg Ala His Leu Thr Glu Val Glu Ser Arg Leu Glu Arg Leu 
    50                  55                  60                  


Glu Gln Leu Phe Leu Leu Ile Phe Pro Arg Glu Asp Leu Asp Met Ile 
65                  70                  75                  80  


Leu Lys Met Asp Ser Leu Gln Asp Ile Lys Ala Leu Leu Thr Gly Leu 
                85                  90                  95      


Phe Val Gln Asp Asn Val Asn Lys Asp Ala Val Thr Asp Arg Leu Ala 
            100                 105                 110         


Ser Val Glu Thr Asp Met Pro Leu Thr Leu Arg Gln His Arg Ile Ser 
        115                 120                 125             


Ala Thr Ser Ser Ser Glu Glu Ser Ser Asn Lys Gly Gln Arg Gln Leu 
    130                 135                 140                 


Thr Val Ser 
145         


<210>  192
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210>  193
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  193

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


<210>  194
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Glu Ser Ser Ala Lys Met Glu Ser Gly Gly Ala Gly Gln Gln Pro 
1               5                   10                  15      


Gln Pro Gln Pro Gln Gln Pro Phe Leu Pro Pro Ala Ala Cys Phe Phe 
            20                  25                  30          


Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gln 
        35                  40                  45              


Ser Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Pro 
    50                  55                  60                  


Gln Leu Arg Pro Ala Ala Asp Gly Gln Pro Ser Gly Gly Gly His Lys 
65                  70                  75                  80  


Ser Ala Pro Lys Gln Val Lys Arg Gln Arg Ser Ser Ser Pro Glu Leu 
                85                  90                  95      


Met Arg Cys Lys Arg Arg Leu Asn Phe Ser Gly Phe Gly Tyr Ser Leu 
            100                 105                 110         


Pro Gln Gln Gln Pro Ala Ala Val Ala Arg Arg Asn Glu Arg Glu Arg 
        115                 120                 125             


Asn Arg Val Lys Leu Val Asn Leu Gly Phe Ala Thr Leu Arg Glu His 
    130                 135                 140                 


Val Pro Asn Gly Ala Ala Asn Lys Lys Met Ser Lys Val Glu Thr Leu 
145                 150                 155                 160 


Arg Ser Ala Val Glu Tyr Ile Arg Ala Leu Gln Gln Leu Leu Asp Glu 
                165                 170                 175     


His Asp Ala Val Ser Ala Ala Phe Gln Ala Gly Val Leu Ser Pro Thr 
            180                 185                 190         


Ile Ser Pro Asn Tyr Ser Asn Asp Leu Asn Ser Met Ala Gly Ser Pro 
        195                 200                 205             


Val Ser Ser Tyr Ser Ser Asp Glu Gly Ser Tyr Asp Pro Leu Ser Pro 
    210                 215                 220                 


Glu Glu Gln Glu Leu Leu Asp Phe Thr Asn Trp Phe 
225                 230                 235     


<210>  195
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  195

Met Tyr Val Ser Tyr Leu Leu Asp Lys Asp Val Ser Met Tyr Pro Ser 
1               5                   10                  15      


Ser Val Arg His Ser Gly Gly Leu Asn Leu Ala Pro Gln Asn Phe Val 
            20                  25                  30          


Ser Pro Pro Gln Tyr Pro Asp Tyr Gly Gly Tyr His Val Ala Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Ala Asn Leu Asp Ser Ala Gln Ser Pro Gly Pro Ser 
    50                  55                  60                  


Trp Pro Ala Ala Tyr Gly Ala Pro Leu Arg Glu Asp Trp Asn Gly Tyr 
65                  70                  75                  80  


Ala Pro Gly Gly Ala Ala Ala Ala Ala Asn Ala Val Ala His Gly Leu 
                85                  90                  95      


Asn Gly Gly Ser Pro Ala Ala Ala Met Gly Tyr Ser Ser Pro Ala Asp 
            100                 105                 110         


Tyr His Pro His His His Pro His His His Pro His His Pro Ala Ala 
        115                 120                 125             


Ala Pro Ser Cys Ala Ser Gly Leu Leu Gln Thr Leu Asn Pro Gly Pro 
    130                 135                 140                 


Pro Gly Pro Ala Ala Thr Ala Ala Ala Glu Gln Leu Ser Pro Gly Gly 
145                 150                 155                 160 


Gln Arg Arg Asn Leu Cys Glu Trp Met Arg Lys Pro Ala Gln Gln Ser 
                165                 170                 175     


Leu Gly Ser Gln Val Lys Thr Arg Thr Lys Asp Lys Tyr Arg Val Val 
            180                 185                 190         


Tyr Thr Asp His Gln Arg Leu Glu Leu Glu Lys Glu Phe His Tyr Ser 
        195                 200                 205             


Arg Tyr Ile Thr Ile Arg Arg Lys Ala Glu Leu Ala Ala Thr Leu Gly 
    210                 215                 220                 


Leu Ser Glu Arg Gln Val Lys Ile Trp Phe Gln Asn Arg Arg Ala Lys 
225                 230                 235                 240 


Glu Arg Lys Ile Asn Lys Lys Lys Leu Gln Gln Gln Gln Gln Gln Gln 
                245                 250                 255     


Pro Pro Gln Pro Pro Pro Pro Pro Pro Gln Pro Pro Gln Pro Gln Pro 
            260                 265                 270         


Gly Pro Leu Arg Ser Val Pro Glu Pro Leu Ser Pro Val Ser Ser Leu 
        275                 280                 285             


Gln Ala Ser Val Ser Gly Ser Val Pro Gly Val Leu Gly Pro Thr Gly 
    290                 295                 300                 


Gly Val Leu Asn Pro Thr Val Thr Gln 
305                 310             


<210>  196
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Thr Met Glu Ser Gly Ala Glu Asn Gln Gln Ser Gly Asp Ala Ala 
1               5                   10                  15      


Val Thr Glu Ala Glu Asn Gln Gln Met Thr Val Gln Ala Gln Pro Gln 
            20                  25                  30          


Ile Ala Thr Leu Ala Gln Val Ser Met Pro Ala Ala His Ala Thr Ser 
        35                  40                  45              


Ser Ala Pro Thr Val Thr Leu Val Gln Leu Pro Asn Gly Gln Thr Val 
    50                  55                  60                  


Gln Val His Gly Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln Ser 
65                  70                  75                  80  


Pro Gln Val Gln Thr Val Gln Ser Ser Cys Lys Asp Leu Lys Arg Leu 
                85                  90                  95      


Phe Ser Gly Thr Gln Ile Ser Thr Ile Ala Glu Ser Glu Asp Ser Gln 
            100                 105                 110         


Glu Ser Val Asp Ser Val Thr Asp Ser Gln Lys Arg Arg Glu Ile Leu 
        115                 120                 125             


Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Asp Leu Ser Ser Asp 
    130                 135                 140                 


Ala Pro Gly Val Pro Arg Ile Glu Glu Glu Lys Ser Glu Glu Glu Thr 
145                 150                 155                 160 


Ser Ala Pro Ala Ile Thr Thr Val Thr Val Pro Thr Pro Ile Tyr Gln 
                165                 170                 175     


Thr Ser Ser Gly Gln Tyr Ile Ala Ile Thr Gln Gly Gly Ala Ile Gln 
            180                 185                 190         


Leu Ala Asn Asn Gly Thr Asp Gly Val Gln Gly Leu Gln Thr Leu Thr 
        195                 200                 205             


Met Thr Asn Ala Ala Ala Thr Gln Pro Gly Thr Thr Ile Leu Gln Tyr 
    210                 215                 220                 


Ala Gln Thr Thr Asp Gly Gln Gln Ile Leu Val Pro Ser Asn Gln Val 
225                 230                 235                 240 


Val Val Gln Ala Ala Ser Gly Asp Val Gln Thr Tyr Gln Ile Arg Thr 
                245                 250                 255     


Ala Pro Thr Ser Thr Ile Ala Pro Gly Val Val Met Ala Ser Ser Pro 
            260                 265                 270         


Ala Leu Pro Thr Gln Pro Ala Glu Glu Ala Ala Arg Lys Arg Glu Val 
        275                 280                 285             


Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys 
    290                 295                 300                 


Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu Glu Asn 
305                 310                 315                 320 


Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr 
                325                 330                 335     


Cys His Lys Ser Asp 
            340     


<210>  197
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  197

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  198
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Gln Leu Gly Glu Gln Leu Leu Val Ser Ser Val Asn Leu Pro Gly 
1               5                   10                  15      


Ala His Phe Tyr Pro Leu Glu Ser Ala Arg Gly Gly Ser Gly Gly Ser 
            20                  25                  30          


Ala Gly His Leu Pro Ser Ala Ala Pro Ser Pro Gln Lys Leu Asp Leu 
        35                  40                  45              


Asp Lys Ala Ser Lys Lys Phe Ser Gly Ser Leu Ser Cys Glu Ala Val 
    50                  55                  60                  


Ser Gly Glu Pro Ala Ala Ala Ser Ala Gly Ala Pro Ala Ala Met Leu 
65                  70                  75                  80  


Ser Asp Thr Asp Ala Gly Asp Ala Phe Ala Ser Ala Ala Ala Val Ala 
                85                  90                  95      


Lys Pro Gly Pro Pro Asp Gly Arg Lys Gly Ser Pro Cys Gly Glu Glu 
            100                 105                 110         


Glu Leu Pro Ser Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Thr Ala Arg Tyr Ser Met Asp Ser Leu Ser Ser Glu Arg Tyr 
    130                 135                 140                 


Tyr Leu Gln Ser Pro Gly Pro Gln Gly Ser Glu Leu Ala Ala Pro Cys 
145                 150                 155                 160 


Ser Leu Phe Pro Tyr Gln Ala Ala Ala Gly Ala Pro His Gly Pro Val 
                165                 170                 175     


Tyr Pro Ala Pro Asn Gly Ala Arg Tyr Pro Tyr Gly Ser Met Leu Pro 
            180                 185                 190         


Pro Gly Gly Phe Pro Ala Ala Val Cys Pro Pro Gly Arg Ala Gln Phe 
        195                 200                 205             


Gly Pro Gly Ala Gly Ala Gly Ser Gly Ala Gly Gly Ser Ser Gly Gly 
    210                 215                 220                 


Gly Gly Gly Pro Gly Thr Tyr Gln Tyr Ser Gln Gly Ala Pro Leu Tyr 
225                 230                 235                 240 


Gly Pro Tyr Pro Gly Ala Ala Ala Ala Gly Ser Cys Gly Gly Leu Gly 
                245                 250                 255     


Gly Leu Gly Val Pro Gly Ser Gly Phe Arg Ala His Val Tyr Leu Cys 
            260                 265                 270         


Asn Arg Pro Leu Trp Leu Lys Phe His Arg His Gln Thr Glu Met Ile 
        275                 280                 285             


Ile Thr Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Asn Ile 
    290                 295                 300                 


Asn Gly Leu Asn Pro Thr Ala His Tyr Asn Val Phe Val Glu Val Val 
305                 310                 315                 320 


Leu Ala Asp Pro Asn His Trp Arg Phe Gln Gly Gly Lys Trp Val Thr 
                325                 330                 335     


Cys Gly Lys Ala Asp Asn Asn Met Gln Gly Asn Lys Met Tyr Val His 
            340                 345                 350         


Pro Glu Ser Pro Asn Thr Gly Ser His Trp Met Arg Gln Glu Ile Ser 
        355                 360                 365             


Phe Gly Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Asn Asn Asn Asn 
    370                 375                 380                 


Thr Gln Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu 
385                 390                 395                 400 


His Ile Val Glu Val Thr Glu Asp Gly Val Glu Asp Leu Asn Glu Pro 
                405                 410                 415     


Ser Lys Thr Gln Thr Phe Thr Phe Ser Glu Thr Gln Phe Ile Ala Val 
            420                 425                 430         


Thr Ala Tyr Gln Asn Thr Asp Ile Thr Gln Leu Lys Ile Asp His Asn 
        435                 440                 445             


Pro Phe Ala Lys Gly Phe Arg Asp Asn Tyr Asp Ser Ser His Gln Ile 
    450                 455                 460                 


Val Pro Gly Gly Arg Tyr Gly Val Gln Ser Phe Phe Pro Glu Pro Phe 
465                 470                 475                 480 


Val Asn Thr Leu Pro Gln Ala Arg Tyr Tyr Asn Gly Glu Arg Thr Val 
                485                 490                 495     


Pro Gln Thr Asn Gly Leu Leu Ser Pro Gln Gln Ser Glu Glu Val Ala 
            500                 505                 510         


Asn Pro Pro Gln Arg Trp Leu Val Thr Pro Val Gln Gln Pro Gly Thr 
        515                 520                 525             


Asn Lys Leu Asp Ile Ser Ser Tyr Glu Ser Glu Tyr Thr Ser Ser Thr 
    530                 535                 540                 


Leu Leu Pro Tyr Gly Ile Lys Ser Leu Pro Leu Gln Thr Ser His Ala 
545                 550                 555                 560 


Leu Gly Tyr Tyr Pro Asp Pro Thr Phe Pro Ala Met Ala Gly Trp Gly 
                565                 570                 575     


Gly Arg Gly Ser Tyr Gln Arg Lys Met Ala Ala Gly Leu Pro Trp Thr 
            580                 585                 590         


Ser Arg Thr Ser Pro Thr Val Phe Ser Glu Asp Gln Leu Ser Lys Glu 
        595                 600                 605             


Lys Val Lys Glu Glu Ile Gly Ser Ser Trp Ile Glu Thr Pro Pro Ser 
    610                 615                 620                 


Ile Lys Ser Leu Asp Ser Asn Asp Ser Gly Val Tyr Thr Ser Ala Cys 
625                 630                 635                 640 


Lys Arg Arg Arg Leu Ser Pro Ser Asn Ser Ser Asn Glu Asn Ser Pro 
                645                 650                 655     


Ser Ile Lys Cys Glu Asp Ile Asn Ala Glu Glu Tyr Ser Lys Asp Thr 
            660                 665                 670         


Ser Lys Gly Met Gly Gly Tyr Tyr Ala Phe Tyr Thr Thr Pro 
        675                 680                 685     


<210>  199
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  199

Met Met Phe Ser Gly Phe Asn Ala Asp Tyr Glu Ala Ser Ser Ser Arg 
1               5                   10                  15      


Cys Ser Ser Ala Ser Pro Ala Gly Asp Ser Leu Ser Tyr Tyr His Ser 
            20                  25                  30          


Pro Ala Asp Ser Phe Ser Ser Met Gly Ser Pro Val Asn Ala Gln Asp 
        35                  40                  45              


Phe Cys Thr Asp Leu Ala Val Ser Ser Ala Asn Phe Ile Pro Thr Val 
    50                  55                  60                  


Thr Ala Ile Ser Thr Ser Pro Asp Leu Gln Trp Leu Val Gln Pro Ala 
65                  70                  75                  80  


Leu Val Ser Ser Val Ala Pro Ser Gln Thr Arg Ala Pro His Pro Phe 
                85                  90                  95      


Gly Val Pro Ala Pro Ser Ala Gly Ala Tyr Ser Arg Ala Gly Val Val 
            100                 105                 110         


Lys Thr Met Thr Gly Gly Arg Ala Gln Ser Ile Gly Arg Arg Gly Lys 
        115                 120                 125             


Val Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg Ile Arg Arg 
    130                 135                 140                 


Glu Arg Asn Lys Met Ala Ala Ala Lys Cys Arg Asn Arg Arg Arg Glu 
145                 150                 155                 160 


Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys 
                165                 170                 175     


Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys 
            180                 185                 190         


Leu Glu Phe Ile Leu Ala Ala His Arg Pro Ala Cys Lys Ile Pro Asp 
        195                 200                 205             


Asp Leu Gly Phe Pro Glu Glu Met Ser Val Ala Ser Leu Asp Leu Thr 
    210                 215                 220                 


Gly Gly Leu Pro Glu Val Ala Thr Pro Glu Ser Glu Glu Ala Phe Thr 
225                 230                 235                 240 


Leu Pro Leu Leu Asn Asp Pro Glu Pro Lys Pro Ser Val Glu Pro Val 
                245                 250                 255     


Lys Ser Ile Ser Ser Met Glu Leu Lys Thr Glu Pro Phe Asp Asp Phe 
            260                 265                 270         


Leu Phe Pro Ala Ser Ser Arg Pro Ser Gly Ser Glu Thr Ala Arg Ser 
        275                 280                 285             


Val Pro Asp Met Asp Leu Ser Gly Ser Phe Tyr Ala Ala Asp Trp Glu 
    290                 295                 300                 


Pro Leu His Ser Gly Ser Leu Gly Met Gly Pro Met Ala Thr Glu Leu 
305                 310                 315                 320 


Glu Pro Leu Cys Thr Pro Val Val Thr Cys Thr Pro Ser Cys Thr Ala 
                325                 330                 335     


Tyr Thr Ser Ser Phe Val Phe Thr Tyr Pro Glu Ala Asp Ser Phe Pro 
            340                 345                 350         


Ser Cys Ala Ala Ala His Arg Lys Gly Ser Ser Ser Asn Glu Pro Ser 
        355                 360                 365             


Ser Asp Ser Leu Ser Ser Pro Thr Leu Leu Ala Leu 
    370                 375                 380 


<210>  200
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Glu Val Thr Ala Asp Gln Pro Arg Trp Val Ser His His His Pro 
1               5                   10                  15      


Ala Val Leu Asn Gly Gln His Pro Asp Thr His His Pro Gly Leu Ser 
            20                  25                  30          


His Ser Tyr Met Asp Ala Ala Gln Tyr Pro Leu Pro Glu Glu Val Asp 
        35                  40                  45              


Val Leu Phe Asn Ile Asp Gly Gln Gly Asn His Val Pro Pro Tyr Tyr 
    50                  55                  60                  


Gly Asn Ser Val Arg Ala Thr Val Gln Arg Tyr Pro Pro Thr His His 
65                  70                  75                  80  


Gly Ser Gln Val Cys Arg Pro Pro Leu Leu His Gly Ser Leu Pro Trp 
                85                  90                  95      


Leu Asp Gly Gly Lys Ala Leu Gly Ser His His Thr Ala Ser Pro Trp 
            100                 105                 110         


Asn Leu Ser Pro Phe Ser Lys Thr Ser Ile His His Gly Ser Pro Gly 
        115                 120                 125             


Pro Leu Ser Val Tyr Pro Pro Ala Ser Ser Ser Ser Leu Ser Gly Gly 
    130                 135                 140                 


His Ala Ser Pro His Leu Phe Thr Phe Pro Pro Thr Pro Pro Lys Asp 
145                 150                 155                 160 


Val Ser Pro Asp Pro Ser Leu Ser Thr Pro Gly Ser Ala Gly Ser Ala 
                165                 170                 175     


Arg Gln Asp Glu Lys Glu Cys Leu Lys Tyr Gln Val Pro Leu Pro Asp 
            180                 185                 190         


Ser Met Lys Leu Glu Ser Ser His Ser Arg Gly Ser Met Thr Ala Leu 
        195                 200                 205             


Gly Gly Ala Ser Ser Ser Thr His His Pro Ile Thr Thr Tyr Pro Pro 
    210                 215                 220                 


Tyr Val Pro Glu Tyr Ser Ser Gly Leu Phe Pro Pro Ser Ser Leu Leu 
225                 230                 235                 240 


Gly Gly Ser Pro Thr Gly Phe Gly Cys Lys Ser Arg Pro Lys Ala Arg 
                245                 250                 255     


Ser Ser Thr Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Thr Ser Thr 
            260                 265                 270         


Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys 
        275                 280                 285             


Gly Leu Tyr His Lys Met Asn Gly Gln Asn Arg Pro Leu Ile Lys Pro 
    290                 295                 300                 


Lys Arg Arg Leu Ser Ala Ala Arg Arg Ala Gly Thr Ser Cys Ala Asn 
305                 310                 315                 320 


Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Asn Gly Asp 
                325                 330                 335     


Pro Val Cys Asn Ala Cys Gly Leu Tyr Tyr Lys Leu His Asn Ile Asn 
            340                 345                 350         


Arg Pro Leu Thr Met Lys Lys Glu Gly Ile Gln Thr Arg Asn Arg Lys 
        355                 360                 365             


Met Ser Ser Lys Ser Lys Lys Cys Lys Lys Val His Asp Ser Leu Glu 
    370                 375                 380                 


Asp Phe Pro Lys Asn Ser Ser Phe Asn Pro Ala Ala Leu Ser Arg His 
385                 390                 395                 400 


Met Ser Ser Leu Ser His Ile Ser Pro Phe Ser His Ser Ser His Met 
                405                 410                 415     


Leu Thr Thr Pro Thr Pro Met His Pro Pro Ser Ser Leu Ser Phe Gly 
            420                 425                 430         


Pro His His Pro Ser Ser Met Val Thr Ala Met Gly 
        435                 440                 


<210>  201
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  201

Met Asp Asn Ala Arg Met Asn Ser Phe Leu Glu Tyr Pro Ile Leu Ser 
1               5                   10                  15      


Ser Gly Asp Ser Gly Thr Cys Ser Ala Arg Ala Tyr Pro Ser Asp His 
            20                  25                  30          


Arg Ile Thr Thr Phe Gln Ser Cys Ala Val Ser Ala Asn Ser Cys Gly 
        35                  40                  45              


Gly Asp Asp Arg Phe Leu Val Gly Arg Gly Val Gln Ile Gly Ser Pro 
    50                  55                  60                  


His His His His His His His His His His Pro Gln Pro Ala Thr Tyr 
65                  70                  75                  80  


Gln Thr Ser Gly Asn Leu Gly Val Ser Tyr Ser His Ser Ser Cys Gly 
                85                  90                  95      


Pro Ser Tyr Gly Ser Gln Asn Phe Ser Ala Pro Tyr Ser Pro Tyr Ala 
            100                 105                 110         


Leu Asn Gln Glu Ala Asp Val Ser Gly Gly Tyr Pro Gln Cys Ala Pro 
        115                 120                 125             


Ala Val Tyr Ser Gly Asn Leu Ser Ser Pro Met Val Gln His His His 
    130                 135                 140                 


His His Gln Gly Tyr Ala Gly Gly Ala Val Gly Ser Pro Gln Tyr Ile 
145                 150                 155                 160 


His His Ser Tyr Gly Gln Glu His Gln Ser Leu Ala Leu Ala Thr Tyr 
                165                 170                 175     


Asn Asn Ser Leu Ser Pro Leu His Ala Ser His Gln Glu Ala Cys Arg 
            180                 185                 190         


Ser Pro Ala Ser Glu Thr Ser Ser Pro Ala Gln Thr Phe Asp Trp Met 
        195                 200                 205             


Lys Val Lys Arg Asn Pro Pro Lys Thr Gly Lys Val Gly Glu Tyr Gly 
    210                 215                 220                 


Tyr Leu Gly Gln Pro Asn Ala Val Arg Thr Asn Phe Thr Thr Lys Gln 
225                 230                 235                 240 


Leu Thr Glu Leu Glu Lys Glu Phe His Phe Asn Lys Tyr Leu Thr Arg 
                245                 250                 255     


Ala Arg Arg Val Glu Ile Ala Ala Ser Leu Gln Leu Asn Glu Thr Gln 
            260                 265                 270         


Val Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Gln Lys Lys Arg Glu 
        275                 280                 285             


Lys Glu Gly Leu Leu Pro Ile Ser Pro Ala Thr Pro Pro Gly Asn Asp 
    290                 295                 300                 


Glu Lys Ala Glu Glu Ser Ser Glu Lys Ser Ser Ser Ser Pro Cys Val 
305                 310                 315                 320 


Pro Ser Pro Gly Ser Ser Thr Ser Asp Thr Leu Thr Thr Ser His 
                325                 330                 335 


<210>  202
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Pro Val Pro Glu Arg Pro Ala Ala Gly Pro Asp Ser Pro Arg Pro 
1               5                   10                  15      


Gly Thr Arg Arg Ala Ala Pro Arg Val Leu Phe Gly Glu Trp Leu Leu 
            20                  25                  30          


Gly Glu Ile Ser Ser Gly Cys Tyr Glu Gly Leu Gln Trp Leu Asp Glu 
        35                  40                  45              


Ala Arg Thr Cys Phe Arg Val Pro Trp Lys His Phe Ala Arg Lys Asp 
    50                  55                  60                  


Leu Ser Glu Ala Asp Ala Arg Ile Phe Lys Ala Trp Ala Val Ala Arg 
65                  70                  75                  80  


Gly Arg Trp Pro Pro Ser Ser Arg Gly Gly Gly Pro Pro Pro Glu Ala 
                85                  90                  95      


Glu Thr Ala Glu Arg Ala Gly Trp Lys Thr Asn Phe Arg Cys Ala Leu 
            100                 105                 110         


Arg Ser Thr Arg Arg Phe Val Met Leu Arg Asp Asn Ser Gly Asp Pro 
        115                 120                 125             


Ala Asp Pro His Lys Val Tyr Ala Leu Ser Arg Glu Leu Cys Trp Arg 
    130                 135                 140                 


Glu Gly Pro Gly Thr Asp Gln Thr Glu Ala Glu Ala Pro Ala Ala Val 
145                 150                 155                 160 


Pro Pro Pro Gln Gly Gly Pro Pro Gly Pro Phe Leu Ala His Thr His 
                165                 170                 175     


Ala Gly Leu Gln Ala Pro Gly Pro Leu Pro Ala Pro Ala Gly Asp Lys 
            180                 185                 190         


Gly Asp Leu Leu Leu Gln Ala Val Gln Gln Ser Cys Leu Ala Asp His 
        195                 200                 205             


Leu Leu Thr Ala Ser Trp Gly Ala Asp Pro Val Pro Thr Lys Ala Pro 
    210                 215                 220                 


Gly Glu Gly Gln Glu Gly Leu Pro Leu Thr Gly Ala Cys Ala Gly Gly 
225                 230                 235                 240 


Pro Gly Leu Pro Ala Gly Glu Leu Tyr Gly Trp Ala Val Glu Thr Thr 
                245                 250                 255     


Pro Ser Pro Gly Pro Gln Pro Ala Ala Leu Thr Thr Gly Glu Ala Ala 
            260                 265                 270         


Ala Pro Glu Ser Pro His Gln Ala Glu Pro Tyr Leu Ser Pro Ser Pro 
        275                 280                 285             


Ser Ala Cys Thr Ala Val Gln Glu Pro Ser Pro Gly Ala Leu Asp Val 
    290                 295                 300                 


Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln Lys Val Val Gly His 
305                 310                 315                 320 


Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro Asp Pro Ala Val Arg Ala 
                325                 330                 335     


Thr Asp Pro Gln Gln Val Ala Phe Pro Ser Pro Ala Glu Leu Pro Asp 
            340                 345                 350         


Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu Leu Arg His Val Ala Pro 
        355                 360                 365             


Gly Leu His Leu Glu Leu Arg Gly Pro Gln Leu Trp Ala Arg Arg Met 
    370                 375                 380                 


Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Gly Pro Pro Gly Ser Ala 
385                 390                 395                 400 


Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro Arg Asn Cys Asp Thr Pro 
                405                 410                 415     


Ile Phe Asp Phe Arg Val Phe Phe Gln Glu Leu Val Glu Phe Arg Ala 
            420                 425                 430         


Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr Ile Tyr Leu Gly Phe Gly 
        435                 440                 445             


Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys Ser Leu Val Leu Val 
    450                 455                 460                 


Lys Leu Glu Pro Trp Leu Cys Arg Val His Leu Glu Gly Thr Gln Arg 
465                 470                 475                 480 


Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu Ser Leu Cys Leu Ser 
                485                 490                 495     


Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu Cys Phe Leu Met Glu Leu 
            500                 505                 510         


Glu Gln Pro Ala 
        515     


<210>  203
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  203

Met Thr Ala Lys Met Glu Thr Thr Phe Tyr Asp Asp Ala Leu Asn Ala 
1               5                   10                  15      


Ser Phe Leu Pro Ser Glu Ser Gly Pro Tyr Gly Tyr Ser Asn Pro Lys 
            20                  25                  30          


Ile Leu Lys Gln Ser Met Thr Leu Asn Leu Ala Asp Pro Val Gly Ser 
        35                  40                  45              


Leu Lys Pro His Leu Arg Ala Lys Asn Ser Asp Leu Leu Thr Ser Pro 
    50                  55                  60                  


Asp Val Gly Leu Leu Lys Leu Ala Ser Pro Glu Leu Glu Arg Leu Ile 
65                  70                  75                  80  


Ile Gln Ser Ser Asn Gly His Ile Thr Thr Thr Pro Thr Pro Thr Gln 
                85                  90                  95      


Phe Leu Cys Pro Lys Asn Val Thr Asp Glu Gln Glu Gly Phe Ala Glu 
            100                 105                 110         


Gly Phe Val Arg Ala Leu Ala Glu Leu His Ser Gln Asn Thr Leu Pro 
        115                 120                 125             


Ser Val Thr Ser Ala Ala Gln Pro Val Asn Gly Ala Gly Met Val Ala 
    130                 135                 140                 


Pro Ala Val Ala Ser Val Ala Gly Gly Ser Gly Ser Gly Gly Phe Ser 
145                 150                 155                 160 


Ala Ser Leu His Ser Glu Pro Pro Val Tyr Ala Asn Leu Ser Asn Phe 
                165                 170                 175     


Asn Pro Gly Ala Leu Ser Ser Gly Gly Gly Ala Pro Ser Tyr Gly Ala 
            180                 185                 190         


Ala Gly Leu Ala Phe Pro Ala Gln Pro Gln Gln Gln Gln Gln Pro Pro 
        195                 200                 205             


His His Leu Pro Gln Gln Met Pro Val Gln His Pro Arg Leu Gln Ala 
    210                 215                 220                 


Leu Lys Glu Glu Pro Gln Thr Val Pro Glu Met Pro Gly Glu Thr Pro 
225                 230                 235                 240 


Pro Leu Ser Pro Ile Asp Met Glu Ser Gln Glu Arg Ile Lys Ala Glu 
                245                 250                 255     


Arg Lys Arg Met Arg Asn Arg Ile Ala Ala Ser Lys Cys Arg Lys Arg 
            260                 265                 270         


Lys Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys 
        275                 280                 285             


Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln 
    290                 295                 300                 


Val Ala Gln Leu Lys Gln Lys Val Met Asn His Val Asn Ser Gly Cys 
305                 310                 315                 320 


Gln Leu Met Leu Thr Gln Gln Leu Gln Thr Phe 
                325                 330     


<210>  204
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Gly Arg Lys Lys Ile Gln Ile Gln Arg Ile Thr Asp Glu Arg Asn 
1               5                   10                  15      


Arg Gln Val Thr Phe Thr Lys Arg Lys Phe Gly Leu Met Lys Lys Ala 
            20                  25                  30          


Tyr Glu Leu Ser Val Leu Cys Asp Cys Glu Ile Ala Leu Ile Ile Phe 
        35                  40                  45              


Asn His Ser Asn Lys Leu Phe Gln Tyr Ala Ser Thr Asp Met Asp Lys 
    50                  55                  60                  


Val Leu Leu Lys Tyr Thr Glu Tyr Asn Glu Pro His Glu Ser Arg Thr 
65                  70                  75                  80  


Asn Ala Asp Ile Ile Glu Thr Leu Arg Lys Lys Gly Phe Asn Gly Cys 
                85                  90                  95      


Asp Ser Pro Glu Pro Asp Gly Glu Asp Ser Leu Glu Gln Ser Pro Leu 
            100                 105                 110         


Leu Glu Asp Lys Tyr Arg Arg Ala Ser Glu Glu Leu Asp Gly Leu Phe 
        115                 120                 125             


Arg Arg Tyr Gly Ser Thr Val Pro Ala Pro Asn Phe Ala Met Pro Val 
    130                 135                 140                 


Thr Val Pro Val Ser Asn Gln Ser Ser Leu Gln Phe Ser Asn Pro Ser 
145                 150                 155                 160 


Gly Ser Leu Val Thr Pro Ser Leu Val Thr Ser Ser Leu Thr Asp Pro 
                165                 170                 175     


Arg Leu Leu Ser Pro Gln Gln Pro Ala Leu Gln Arg Asn Ser Val Ser 
            180                 185                 190         


Pro Gly Leu Pro Gln Arg Pro Ala Ser Ala Gly Ala Met Leu Gly Gly 
        195                 200                 205             


Asp Leu Asn Ser Ala Asn Gly Ala Cys Pro Ser Pro Val Gly Asn Gly 
    210                 215                 220                 


Tyr Val Ser Ala Arg Ala Ser Pro Gly Leu Leu Pro Val Ala Asn Gly 
225                 230                 235                 240 


Asn Ser Leu Asn Lys Val Ile Pro Ala Lys Ser Pro Pro Pro Pro Thr 
                245                 250                 255     


His Ser Thr Gln Leu Gly Ala Pro Ser Arg Lys Pro Asp Leu Arg Val 
            260                 265                 270         


Ile Thr Ser Gln Ala Gly Lys Gly Leu Met His His Leu Thr Glu Asp 
        275                 280                 285             


His Leu Asp Leu Asn Asn Ala Gln Arg Leu Gly Val Ser Gln Ser Thr 
    290                 295                 300                 


His Ser Leu Thr Thr Pro Val Val Ser Val Ala Thr Pro Ser Leu Leu 
305                 310                 315                 320 


Ser Gln Gly Leu Pro Phe Ser Ser Met Pro Thr Ala Tyr Asn Thr Asp 
                325                 330                 335     


Tyr Gln Leu Thr Ser Ala Glu Leu Ser Ser Leu Pro Ala Phe Ser Ser 
            340                 345                 350         


Pro Gly Gly Leu Ser Leu Gly Asn Val Thr Ala Trp Gln Gln Pro Gln 
        355                 360                 365             


Gln Pro Gln Gln Pro Gln Gln Pro Gln Pro Pro Gln Gln Gln Pro Pro 
    370                 375                 380                 


Gln Pro Gln Gln Pro Gln Pro Gln Gln Pro Gln Gln Pro Gln Gln Pro 
385                 390                 395                 400 


Pro Gln Gln Gln Ser His Leu Val Pro Val Ser Leu Ser Asn Leu Ile 
                405                 410                 415     


Pro Gly Ser Pro Leu Pro His Val Gly Ala Ala Leu Thr Val Thr Thr 
            420                 425                 430         


His Pro His Ile Ser Ile Lys Ser Glu Pro Val Ser Pro Ser Arg Glu 
        435                 440                 445             


Arg Ser Pro Ala Pro Pro Pro Pro Ala Val Phe Pro Ala Ala Arg Pro 
    450                 455                 460                 


Glu Pro Gly Asp Gly Leu Ser Ser Pro Ala Gly Gly Ser Tyr Glu Thr 
465                 470                 475                 480 


Gly Asp Arg Asp Asp Gly Arg Gly Asp Phe Gly Pro Thr Leu Gly Leu 
                485                 490                 495     


Leu Arg Pro Ala Pro Glu Pro Glu Ala Glu Gly Ser Ala Val Lys Arg 
            500                 505                 510         


Met Arg Leu Asp Thr Trp Thr Leu Lys 
        515                 520     


<210>  205
<211>  356
<212>  PRT
<213>  Homo sapiens

<400>  205

Met Thr Lys Ser Tyr Ser Glu Ser Gly Leu Met Gly Glu Pro Gln Pro 
1               5                   10                  15      


Gln Gly Pro Pro Ser Trp Thr Asp Glu Cys Leu Ser Ser Gln Asp Glu 
            20                  25                  30          


Glu His Glu Ala Asp Lys Lys Glu Asp Asp Leu Glu Ala Met Asn Ala 
        35                  40                  45              


Glu Glu Asp Ser Leu Arg Asn Gly Gly Glu Glu Glu Asp Glu Asp Glu 
    50                  55                  60                  


Asp Leu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Asp Asp Gln Lys 
65                  70                  75                  80  


Pro Lys Arg Arg Gly Pro Lys Lys Lys Lys Met Thr Lys Ala Arg Leu 
                85                  90                  95      


Glu Arg Phe Lys Leu Arg Arg Met Lys Ala Asn Ala Arg Glu Arg Asn 
            100                 105                 110         


Arg Met His Gly Leu Asn Ala Ala Leu Asp Asn Leu Arg Lys Val Val 
        115                 120                 125             


Pro Cys Tyr Ser Lys Thr Gln Lys Leu Ser Lys Ile Glu Thr Leu Arg 
    130                 135                 140                 


Leu Ala Lys Asn Tyr Ile Trp Ala Leu Ser Glu Ile Leu Arg Ser Gly 
145                 150                 155                 160 


Lys Ser Pro Asp Leu Val Ser Phe Val Gln Thr Leu Cys Lys Gly Leu 
                165                 170                 175     


Ser Gln Pro Thr Thr Asn Leu Val Ala Gly Cys Leu Gln Leu Asn Pro 
            180                 185                 190         


Arg Thr Phe Leu Pro Glu Gln Asn Gln Asp Met Pro Pro His Leu Pro 
        195                 200                 205             


Thr Ala Ser Ala Ser Phe Pro Val His Pro Tyr Ser Tyr Gln Ser Pro 
    210                 215                 220                 


Gly Leu Pro Ser Pro Pro Tyr Gly Thr Met Asp Ser Ser His Val Phe 
225                 230                 235                 240 


His Val Lys Pro Pro Pro His Ala Tyr Ser Ala Ala Leu Glu Pro Phe 
                245                 250                 255     


Phe Glu Ser Pro Leu Thr Asp Cys Thr Ser Pro Ser Phe Asp Gly Pro 
            260                 265                 270         


Leu Ser Pro Pro Leu Ser Ile Asn Gly Asn Phe Ser Phe Lys His Glu 
        275                 280                 285             


Pro Ser Ala Glu Phe Glu Lys Asn Tyr Ala Phe Thr Met His Tyr Pro 
    290                 295                 300                 


Ala Ala Thr Leu Ala Gly Ala Gln Ser His Gly Ser Ile Phe Ser Gly 
305                 310                 315                 320 


Thr Ala Ala Pro Arg Cys Glu Ile Pro Ile Asp Asn Ile Met Ser Phe 
                325                 330                 335     


Asp Ser His Ser His His Glu Arg Val Met Ser Ala Gln Leu Asn Ala 
            340                 345                 350         


Ile Phe His Asp 
        355     


<210>  206
<211>  812
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Thr Gly Leu Glu Asp Gln Glu Phe Asp Phe Glu Phe Leu Phe Glu 
1               5                   10                  15      


Phe Asn Gln Arg Asp Glu Gly Ala Ala Ala Ala Ala Pro Glu His Tyr 
            20                  25                  30          


Gly Tyr Ala Ser Ser Asn Val Ser Pro Ala Leu Pro Leu Pro Thr Ala 
        35                  40                  45              


His Ser Thr Leu Pro Ala Pro Cys His Asn Leu Gln Thr Ser Thr Pro 
    50                  55                  60                  


Gly Ile Ile Pro Pro Ala Asp His Pro Ser Gly Tyr Gly Ala Ala Leu 
65                  70                  75                  80  


Asp Gly Gly Pro Ala Gly Tyr Phe Leu Ser Ser Gly His Thr Arg Pro 
                85                  90                  95      


Asp Gly Ala Pro Ala Leu Glu Ser Pro Arg Ile Glu Ile Thr Ser Cys 
            100                 105                 110         


Leu Gly Leu Tyr His Asn Asn Asn Gln Phe Phe His Asp Val Glu Val 
        115                 120                 125             


Glu Asp Val Leu Pro Ser Ser Lys Arg Ser Pro Ser Thr Ala Thr Leu 
    130                 135                 140                 


Ser Leu Pro Ser Leu Glu Ala Tyr Arg Asp Pro Ser Cys Leu Ser Pro 
145                 150                 155                 160 


Ala Ser Ser Leu Ser Ser Arg Ser Cys Asn Ser Glu Ala Ser Ser Tyr 
                165                 170                 175     


Glu Ser Asn Tyr Ser Tyr Pro Tyr Ala Ser Pro Gln Thr Ser Pro Trp 
            180                 185                 190         


Gln Ser Pro Cys Val Ser Pro Lys Thr Thr Asp Pro Glu Glu Gly Phe 
        195                 200                 205             


Pro Arg Gly Leu Gly Ala Cys Thr Leu Leu Ser Ser Pro Arg His Ser 
    210                 215                 220                 


Pro Ser Thr Ser Pro Arg Ala Ser Val Thr Glu Glu Ser Trp Leu Gly 
225                 230                 235                 240 


Ala Arg Ser Ser Arg Pro Ala Ser Pro Cys Asn Lys Arg Lys Tyr Ser 
                245                 250                 255     


Leu Asn Gly Arg Gln Pro Pro Tyr Ser Pro His His Ser Pro Thr Pro 
            260                 265                 270         


Ser Pro His Gly Ser Pro Arg Val Ser Val Thr Asp Asp Ser Trp Leu 
        275                 280                 285             


Gly Asn Thr Thr Gln Tyr Thr Ser Ser Ala Ile Val Ala Ala Ile Asn 
    290                 295                 300                 


Ala Leu Thr Thr Asp Ser Ser Leu Asp Leu Gly Asp Gly Val Pro Val 
305                 310                 315                 320 


Lys Ser Arg Lys Thr Thr Leu Glu Gln Pro Pro Ser Val Ala Leu Lys 
                325                 330                 335     


Val Glu Pro Val Gly Glu Asp Leu Gly Ser Pro Pro Pro Pro Ala Asp 
            340                 345                 350         


Phe Ala Pro Glu Asp Tyr Ser Ser Phe Gln His Ile Arg Lys Gly Gly 
        355                 360                 365             


Phe Cys Asp Gln Tyr Leu Ala Val Pro Gln His Pro Tyr Gln Trp Ala 
    370                 375                 380                 


Lys Pro Lys Pro Leu Ser Pro Thr Ser Tyr Met Ser Pro Thr Leu Pro 
385                 390                 395                 400 


Ala Leu Asp Trp Gln Leu Pro Ser His Ser Gly Pro Tyr Glu Leu Arg 
                405                 410                 415     


Ile Glu Val Gln Pro Lys Ser His His Arg Ala His Tyr Glu Thr Glu 
            420                 425                 430         


Gly Ser Arg Gly Ala Val Lys Ala Ser Ala Gly Gly His Pro Ile Val 
        435                 440                 445             


Gln Leu His Gly Tyr Leu Glu Asn Glu Pro Leu Met Leu Gln Leu Phe 
    450                 455                 460                 


Ile Gly Thr Ala Asp Asp Arg Leu Leu Arg Pro His Ala Phe Tyr Gln 
465                 470                 475                 480 


Val His Arg Ile Thr Gly Lys Thr Val Ser Thr Thr Ser His Glu Ala 
                485                 490                 495     


Ile Leu Ser Asn Thr Lys Val Leu Glu Ile Pro Leu Leu Pro Glu Asn 
            500                 505                 510         


Ser Met Arg Ala Val Ile Asp Cys Ala Gly Ile Leu Lys Leu Arg Asn 
        515                 520                 525             


Ser Asp Ile Glu Leu Arg Lys Gly Glu Thr Asp Ile Gly Arg Lys Asn 
    530                 535                 540                 


Thr Arg Val Arg Leu Val Phe Arg Val His Val Pro Gln Pro Ser Gly 
545                 550                 555                 560 


Arg Thr Leu Ser Leu Gln Val Ala Ser Asn Pro Ile Glu Cys Ser Gln 
                565                 570                 575     


Arg Ser Ala Gln Glu Leu Pro Leu Val Glu Lys Gln Ser Thr Asp Ser 
            580                 585                 590         


Tyr Pro Val Val Gly Gly Lys Lys Met Val Leu Ser Gly His Asn Phe 
        595                 600                 605             


Leu Gln Asp Ser Lys Val Ile Phe Val Glu Lys Ala Pro Asp Gly His 
    610                 615                 620                 


His Val Trp Glu Met Glu Ala Lys Thr Asp Arg Asp Leu Cys Lys Pro 
625                 630                 635                 640 


Asn Ser Leu Val Val Glu Ile Pro Pro Phe Arg Asn Gln Arg Ile Thr 
                645                 650                 655     


Ser Pro Val His Val Ser Phe Tyr Val Cys Asn Gly Lys Arg Lys Arg 
            660                 665                 670         


Ser Gln Tyr Gln Arg Phe Thr Tyr Leu Pro Ala Asn Val Pro Ile Ile 
        675                 680                 685             


Lys Thr Glu Pro Thr Asp Asp Tyr Glu Pro Ala Pro Thr Cys Gly Pro 
    690                 695                 700                 


Val Ser Gln Gly Leu Ser Pro Leu Pro Arg Pro Tyr Tyr Ser Gln Gln 
705                 710                 715                 720 


Leu Ala Met Pro Pro Asp Pro Ser Ser Cys Leu Val Ala Gly Phe Pro 
                725                 730                 735     


Pro Cys Pro Gln Arg Ser Thr Leu Met Pro Ala Ala Pro Gly Val Ser 
            740                 745                 750         


Pro Lys Leu His Asp Leu Ser Pro Ala Ala Tyr Thr Lys Gly Val Ala 
        755                 760                 765             


Ser Pro Gly His Cys His Leu Gly Leu Pro Gln Pro Ala Gly Glu Ala 
    770                 775                 780                 


Pro Ala Val Gln Asp Val Pro Arg Pro Val Ala Thr His Pro Gly Ser 
785                 790                 795                 800 


Pro Gly Gln Pro Pro Pro Ala Leu Leu Pro Gln Gln 
                805                 810         


<210>  207
<211>  968
<212>  PRT
<213>  Homo sapiens

<400>  207

Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 
1               5                   10                  15      


Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 
            20                  25                  30          


Pro Gln Met Ala Leu Pro Thr Asp Gly Pro Tyr Leu Gln Ile Leu Glu 
        35                  40                  45              


Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly Pro 
    50                  55                  60                  


Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys Ser 
65                  70                  75                  80  


Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val Ile 
                85                  90                  95      


Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His Ser 
            100                 105                 110         


Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala Gly 
        115                 120                 125             


Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His Val 
    130                 135                 140                 


Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu Ala 
145                 150                 155                 160 


Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu Ala 
                165                 170                 175     


Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg Glu 
            180                 185                 190         


Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met Asp 
        195                 200                 205             


Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser Thr 
    210                 215                 220                 


Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile Tyr 
225                 230                 235                 240 


Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met Asp 
                245                 250                 255     


Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu Cys 
            260                 265                 270         


Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu Glu 
        275                 280                 285             


Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr Asp 
    290                 295                 300                 


Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys Asp 
305                 310                 315                 320 


Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg Lys 
                325                 330                 335     


Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro Glu 
            340                 345                 350         


Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met Pro 
        355                 360                 365             


Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly Gly 
    370                 375                 380                 


Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser Thr 
385                 390                 395                 400 


Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly Gly 
                405                 410                 415     


Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys His 
            420                 425                 430         


Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp Lys 
        435                 440                 445             


Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu Thr 
    450                 455                 460                 


Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly Glu 
465                 470                 475                 480 


Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly Val 
                485                 490                 495     


Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg His 
            500                 505                 510         


Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met Leu 
        515                 520                 525             


Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly Asp 
    530                 535                 540                 


Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val Arg 
545                 550                 555                 560 


Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile Asn 
                565                 570                 575     


Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile Thr 
            580                 585                 590         


Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp Leu 
        595                 600                 605             


Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala Lys 
    610                 615                 620                 


Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys Ala 
625                 630                 635                 640 


Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile His 
                645                 650                 655     


Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val Ala 
            660                 665                 670         


Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr Ala 
        675                 680                 685             


Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys Leu 
    690                 695                 700                 


Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly Thr 
705                 710                 715                 720 


Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala Ala 
                725                 730                 735     


Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu Pro 
            740                 745                 750         


Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu Gly 
        755                 760                 765             


Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln Val 
    770                 775                 780                 


Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser Asp 
785                 790                 795                 800 


Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val Lys 
                805                 810                 815     


Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn Trp 
            820                 825                 830         


Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala Phe 
        835                 840                 845             


Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu Val 
    850                 855                 860                 


Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met Gly 
865                 870                 875                 880 


Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val Lys 
                885                 890                 895     


Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr Arg 
            900                 905                 910         


Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser Gly 
        915                 920                 925             


Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr Ser 
    930                 935                 940                 


Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly Gln 
945                 950                 955                 960 


Glu Gly Pro Leu Glu Gly Lys Ile 
                965             


<210>  208
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Pro Arg Ser Phe Leu Val Arg Lys Pro Ser Asp Pro Asn Arg Lys 
1               5                   10                  15      


Pro Asn Tyr Ser Glu Leu Gln Asp Ser Asn Pro Glu Phe Thr Phe Gln 
            20                  25                  30          


Gln Pro Tyr Asp Gln Ala His Leu Leu Ala Ala Ile Pro Pro Pro Glu 
        35                  40                  45              


Ile Leu Asn Pro Thr Ala Ser Leu Pro Met Leu Ile Trp Asp Ser Val 
    50                  55                  60                  


Leu Ala Pro Gln Ala Gln Pro Ile Ala Trp Ala Ser Leu Arg Leu Gln 
65                  70                  75                  80  


Glu Ser Pro Arg Val Ala Glu Leu Thr Ser Leu Ser Asp Glu Asp Ser 
                85                  90                  95      


Gly Lys Gly Ser Gln Pro Pro Ser Pro Pro Ser Pro Ala Pro Ser Ser 
            100                 105                 110         


Phe Ser Ser Thr Ser Val Ser Ser Leu Glu Ala Glu Ala Tyr Ala Ala 
        115                 120                 125             


Phe Pro Gly Leu Gly Gln Val Pro Lys Gln Leu Ala Gln Leu Ser Glu 
    130                 135                 140                 


Ala Lys Asp Leu Gln Ala Arg Lys Ala Phe Asn Cys Lys Tyr Cys Asn 
145                 150                 155                 160 


Lys Glu Tyr Leu Ser Leu Gly Ala Leu Lys Met His Ile Arg Ser His 
                165                 170                 175     


Thr Leu Pro Cys Val Cys Gly Thr Cys Gly Lys Ala Phe Ser Arg Pro 
            180                 185                 190         


Trp Leu Leu Gln Gly His Val Arg Thr His Thr Gly Glu Lys Pro Phe 
        195                 200                 205             


Ser Cys Pro His Cys Ser Arg Ala Phe Ala Asp Arg Ser Asn Leu Arg 
    210                 215                 220                 


Ala His Leu Gln Thr His Ser Asp Val Lys Lys Tyr Gln Cys Gln Ala 
225                 230                 235                 240 


Cys Ala Arg Thr Phe Ser Arg Met Ser Leu Leu His Lys His Gln Glu 
                245                 250                 255     


Ser Gly Cys Ser Gly Cys Pro Arg 
            260                 


<210>  209
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745                 750 


<210>  210
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Glu Pro Ser Ser Trp Ser Gly Ser Glu Ser Pro Ala Glu Asn Met 
1               5                   10                  15      


Glu Arg Met Ser Asp Ser Ala Asp Lys Pro Ile Asp Asn Asp Ala Glu 
            20                  25                  30          


Gly Val Trp Ser Pro Asp Ile Glu Gln Ser Phe Gln Glu Ala Leu Ala 
        35                  40                  45              


Ile Tyr Pro Pro Cys Gly Arg Arg Lys Ile Ile Leu Ser Asp Glu Gly 
    50                  55                  60                  


Lys Met Tyr Gly Arg Asn Glu Leu Ile Ala Arg Tyr Ile Lys Leu Arg 
65                  70                  75                  80  


Thr Gly Lys Thr Arg Thr Arg Lys Gln Val Ser Ser His Ile Gln Val 
                85                  90                  95      


Leu Ala Arg Arg Lys Ser Arg Asp Phe His Ser Lys Leu Lys Asp Gln 
            100                 105                 110         


Thr Ala Lys Asp Lys Ala Leu Gln His Met Ala Ala Met Ser Ser Ala 
        115                 120                 125             


Gln Ile Val Ser Ala Thr Ala Ile His Asn Lys Leu Gly Leu Pro Gly 
    130                 135                 140                 


Ile Pro Arg Pro Thr Phe Pro Gly Ala Pro Gly Phe Trp Pro Gly Met 
145                 150                 155                 160 


Ile Gln Thr Gly Gln Pro Gly Ser Ser Gln Asp Val Lys Pro Phe Val 
                165                 170                 175     


Gln Gln Ala Tyr Pro Ile Gln Pro Ala Val Thr Ala Pro Ile Pro Gly 
            180                 185                 190         


Phe Glu Pro Ala Ser Ala Pro Ala Pro Ser Val Pro Ala Trp Gln Gly 
        195                 200                 205             


Arg Ser Ile Gly Thr Thr Lys Leu Arg Leu Val Glu Phe Ser Ala Phe 
    210                 215                 220                 


Leu Glu Gln Gln Arg Asp Pro Asp Ser Tyr Asn Lys His Leu Phe Val 
225                 230                 235                 240 


His Ile Gly His Ala Asn His Ser Tyr Ser Asp Pro Leu Leu Glu Ser 
                245                 250                 255     


Val Asp Ile Arg Gln Ile Tyr Asp Lys Phe Pro Glu Lys Lys Gly Gly 
            260                 265                 270         


Leu Lys Glu Leu Phe Gly Lys Gly Pro Gln Asn Ala Phe Phe Leu Val 
        275                 280                 285             


Lys Phe Trp Ala Asp Leu Asn Cys Asn Ile Gln Asp Asp Ala Gly Ala 
    290                 295                 300                 


Phe Tyr Gly Val Thr Ser Gln Tyr Glu Ser Ser Glu Asn Met Thr Val 
305                 310                 315                 320 


Thr Cys Ser Thr Lys Val Cys Ser Phe Gly Lys Gln Val Val Glu Lys 
                325                 330                 335     


Val Glu Thr Glu Tyr Ala Arg Phe Glu Asn Gly Arg Phe Val Tyr Arg 
            340                 345                 350         


Ile Asn Arg Ser Pro Met Cys Glu Tyr Met Ile Asn Phe Ile His Lys 
        355                 360                 365             


Leu Lys His Leu Pro Glu Lys Tyr Met Met Asn Ser Val Leu Glu Asn 
    370                 375                 380                 


Phe Thr Ile Leu Leu Val Val Thr Asn Arg Asp Thr Gln Glu Thr Leu 
385                 390                 395                 400 


Leu Cys Met Ala Cys Val Phe Glu Val Ser Asn Ser Glu His Gly Ala 
                405                 410                 415     


Gln His His Ile Tyr Arg Leu Val Lys Asp 
            420                 425     


