                         SEQUENCE LISTING

<110>  Urifer Ltd.
 
<120>  MODULATORS OF CELL DEATH PROCESSES

<130>  2388635

<150>  US 62/121,023
<151>  2015-02-26

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1014
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Ser Ser Asp Lys Leu Tyr Arg Val Glu Tyr Ala Lys Ser 
1               5                   10                  15      


Gly Arg Ala Ser Cys Lys Lys Cys Ser Glu Ser Ile Pro Lys Asp Ser 
            20                  25                  30          


Leu Arg Met Ala Ile Met Val Gln Ser Pro Met Phe Asp Gly Lys Val 
        35                  40                  45              


Pro His Trp Tyr His Phe Ser Cys Phe Trp Lys Val Gly His Ser Ile 
    50                  55                  60                  


Arg His Pro Asp Val Glu Val Asp Gly Phe Ser Glu Leu Arg Trp Asp 
65                  70                  75                  80  


Asp Gln Gln Lys Val Lys Lys Thr Ala Glu Ala Gly Gly Val Thr Gly 
                85                  90                  95      


Lys Gly Gln Asp Gly Ile Gly Ser Lys Ala Glu Lys Thr Leu Gly Asp 
            100                 105                 110         


Phe Ala Ala Glu Tyr Ala Lys Ser Asn Arg Ser Thr Cys Lys Gly Cys 
        115                 120                 125             


Met Glu Lys Ile Glu Lys Gly Gln Val Arg Leu Ser Lys Lys Met Val 
    130                 135                 140                 


Asp Pro Glu Lys Pro Gln Leu Gly Met Ile Asp Arg Trp Tyr His Pro 
145                 150                 155                 160 


Gly Cys Phe Val Lys Asn Arg Glu Glu Leu Gly Phe Arg Pro Glu Tyr 
                165                 170                 175     


Ser Ala Ser Gln Leu Lys Gly Phe Ser Leu Leu Ala Thr Glu Asp Lys 
            180                 185                 190         


Glu Ala Leu Lys Lys Gln Leu Pro Gly Val Lys Ser Glu Gly Lys Arg 
        195                 200                 205             


Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys Lys Ser 
    210                 215                 220                 


Lys Lys Glu Lys Asp Lys Asp Ser Lys Leu Glu Lys Ala Leu Lys Ala 
225                 230                 235                 240 


Gln Asn Asp Leu Ile Trp Asn Ile Lys Asp Glu Leu Lys Lys Val Cys 
                245                 250                 255     


Ser Thr Asn Asp Leu Lys Glu Leu Leu Ile Phe Asn Lys Gln Gln Val 
            260                 265                 270         


Pro Ser Gly Glu Ser Ala Ile Leu Asp Arg Val Ala Asp Gly Met Val 
        275                 280                 285             


Phe Gly Ala Leu Leu Pro Cys Glu Glu Cys Ser Gly Gln Leu Val Phe 
    290                 295                 300                 


Lys Ser Asp Ala Tyr Tyr Cys Thr Gly Asp Val Thr Ala Trp Thr Lys 
305                 310                 315                 320 


Cys Met Val Lys Thr Gln Thr Pro Asn Arg Lys Glu Trp Val Thr Pro 
                325                 330                 335     


Lys Glu Phe Arg Glu Ile Ser Tyr Leu Lys Lys Leu Lys Val Lys Lys 
            340                 345                 350         


Gln Asp Arg Ile Phe Pro Pro Glu Thr Ser Ala Ser Val Ala Ala Thr 
        355                 360                 365             


Pro Pro Pro Ser Thr Ala Ser Ala Pro Ala Ala Val Asn Ser Ser Ala 
    370                 375                 380                 


Ser Ala Asp Lys Pro Leu Ser Asn Met Lys Ile Leu Thr Leu Gly Lys 
385                 390                 395                 400 


Leu Ser Arg Asn Lys Asp Glu Val Lys Ala Met Ile Glu Lys Leu Gly 
                405                 410                 415     


Gly Lys Leu Thr Gly Thr Ala Asn Lys Ala Ser Leu Cys Ile Ser Thr 
            420                 425                 430         


Lys Lys Glu Val Glu Lys Met Asn Lys Lys Met Glu Glu Val Lys Glu 
        435                 440                 445             


Ala Asn Ile Arg Val Val Ser Glu Asp Phe Leu Gln Asp Val Ser Ala 
    450                 455                 460                 


Ser Thr Lys Ser Leu Gln Glu Leu Phe Leu Ala His Ile Leu Ser Pro 
465                 470                 475                 480 


Trp Gly Ala Glu Val Lys Ala Glu Pro Val Glu Val Val Ala Pro Arg 
                485                 490                 495     


Gly Lys Ser Gly Ala Ala Leu Ser Lys Lys Ser Lys Gly Gln Val Lys 
            500                 505                 510         


Glu Glu Gly Ile Asn Lys Ser Glu Lys Arg Met Lys Leu Thr Leu Lys 
        515                 520                 525             


Gly Gly Ala Ala Val Asp Pro Asp Ser Gly Leu Glu His Ser Ala His 
    530                 535                 540                 


Val Leu Glu Lys Gly Gly Lys Val Phe Ser Ala Thr Leu Gly Leu Val 
545                 550                 555                 560 


Asp Ile Val Lys Gly Thr Asn Ser Tyr Tyr Lys Leu Gln Leu Leu Glu 
                565                 570                 575     


Asp Asp Lys Glu Asn Arg Tyr Trp Ile Phe Arg Ser Trp Gly Arg Val 
            580                 585                 590         


Gly Thr Val Ile Gly Ser Asn Lys Leu Glu Gln Met Pro Ser Lys Glu 
        595                 600                 605             


Asp Ala Ile Glu His Phe Met Lys Leu Tyr Glu Glu Lys Thr Gly Asn 
    610                 615                 620                 


Ala Trp His Ser Lys Asn Phe Thr Lys Tyr Pro Lys Lys Phe Tyr Pro 
625                 630                 635                 640 


Leu Glu Ile Asp Tyr Gly Gln Asp Glu Glu Ala Val Lys Lys Leu Thr 
                645                 650                 655     


Val Asn Pro Gly Thr Lys Ser Lys Leu Pro Lys Pro Val Gln Asp Leu 
            660                 665                 670         


Ile Lys Met Ile Phe Asp Val Glu Ser Met Lys Lys Ala Met Val Glu 
        675                 680                 685             


Tyr Glu Ile Asp Leu Gln Lys Met Pro Leu Gly Lys Leu Ser Lys Arg 
    690                 695                 700                 


Gln Ile Gln Ala Ala Tyr Ser Ile Leu Ser Glu Val Gln Gln Ala Val 
705                 710                 715                 720 


Ser Gln Gly Ser Ser Asp Ser Gln Ile Leu Asp Leu Ser Asn Arg Phe 
                725                 730                 735     


Tyr Thr Leu Ile Pro His Asp Phe Gly Met Lys Lys Pro Pro Leu Leu 
            740                 745                 750         


Asn Asn Ala Asp Ser Val Gln Ala Lys Val Glu Met Leu Asp Asn Leu 
        755                 760                 765             


Leu Asp Ile Glu Val Ala Tyr Ser Leu Leu Arg Gly Gly Ser Asp Asp 
    770                 775                 780                 


Ser Ser Lys Asp Pro Ile Asp Val Asn Tyr Glu Lys Leu Lys Thr Asp 
785                 790                 795                 800 


Ile Lys Val Val Asp Arg Asp Ser Glu Glu Ala Glu Ile Ile Arg Lys 
                805                 810                 815     


Tyr Val Lys Asn Thr His Ala Thr Thr His Asn Ala Tyr Asp Leu Glu 
            820                 825                 830         


Val Ile Asp Ile Phe Lys Ile Glu Arg Glu Gly Glu Cys Gln Arg Tyr 
        835                 840                 845             


Lys Pro Phe Lys Gln Leu His Asn Arg Arg Leu Leu Trp His Gly Ser 
    850                 855                 860                 


Arg Thr Thr Asn Phe Ala Gly Ile Leu Ser Gln Gly Leu Arg Ile Ala 
865                 870                 875                 880 


Pro Pro Glu Ala Pro Val Thr Gly Tyr Met Phe Gly Lys Gly Ile Tyr 
                885                 890                 895     


Phe Ala Asp Met Val Ser Lys Ser Ala Asn Tyr Cys His Thr Ser Gln 
            900                 905                 910         


Gly Asp Pro Ile Gly Leu Ile Leu Leu Gly Glu Val Ala Leu Gly Asn 
        915                 920                 925             


Met Tyr Glu Leu Lys His Ala Ser His Ile Ser Lys Leu Pro Lys Gly 
    930                 935                 940                 


Lys His Ser Val Lys Gly Leu Gly Lys Thr Thr Pro Asp Pro Ser Ala 
945                 950                 955                 960 


Asn Ile Ser Leu Asp Gly Val Asp Val Pro Leu Gly Thr Gly Ile Ser 
                965                 970                 975     


Ser Gly Val Asn Asp Thr Ser Leu Leu Tyr Asn Glu Tyr Ile Val Tyr 
            980                 985                 990         


Asp Ile Ala Gln Val Asn Leu Lys  Tyr Leu Leu Lys Leu  Lys Phe Asn 
        995                 1000                 1005             


Phe Lys  Thr Ser Leu Trp 
    1010                 


<210>  2
<211>  3677
<212>  DNA
<213>  Homo sapiens

<400>  2
cggtggccgg tgcggcgtgt tcggtggcgg ctctggccgc tcaggcgcct gcggctgggt       60

gagcgcacgc gaggcggcga ggcggcagcg tgtttctagg tcgtggcgtc gggcttccgg      120

agctttgccg gcagctaggg gaggatggcg gagtcttcgg ataagctcta tcgagtcgag      180

tacgccaaga gcgggcgcgc ctcttgcaag aaatgcagcg agagcatccc caaggactcg      240

ctccggatgg ccatcatggt gcagtcgccc atgtttgatg gaaaagtccc acactggtac      300

cacttctcct gcttctggaa ggtgggccac tccatccggc accctgacgt tgaggtggat      360

gggttctctg agcttcggtg ggatgatcag cagaaagtca agaagacagc ggaagctgga      420

ggagtgacag gcaaaggcca ggatggaatt ggtagcaagg cagagaagac tctgggtgac      480

tttgcagcag agtatgccaa gtccaacaga agtacgtgca aggggtgtat ggagaagata      540

gaaaagggcc aggtgcgcct gtccaagaag atggtggacc cggagaagcc acagctaggc      600

atgattgacc gctggtacca tccaggctgc tttgtcaaga acagggagga gctgggtttc      660

cggcccgagt acagtgcgag tcagctcaag ggcttcagcc tccttgctac agaggataaa      720

gaagccctga agaagcagct cccaggagtc aagagtgaag gaaagagaaa aggcgatgag      780

gtggatggag tggatgaagt ggcgaagaag aaatctaaaa aagaaaaaga caaggatagt      840

aagcttgaaa aagccctaaa ggctcagaac gacctgatct ggaacatcaa ggacgagcta      900

aagaaagtgt gttcaactaa tgacctgaag gagctactca tcttcaacaa gcagcaagtg      960

ccttctgggg agtcggcgat cttggaccga gtagccgatg gcatggtgtt cggtgccctc     1020

cttccctgcg aggaatgctc gggtcagctg gtcttcaaga gcgatgccta ttactgcact     1080

ggggacgtca ctgcctggac caagtgtatg gtcaagacac agacacccaa ccggaaggag     1140

tgggtaaccc caaaggaatt ccgagaaatc tcttacctca agaaattgaa ggttaaaaaa     1200

caggaccgta tattcccccc agaaaccagc gcctccgtgg cggccacgcc tccgccctcc     1260

acagcctcgg ctcctgctgc tgtgaactcc tctgcttcag cagataagcc attatccaac     1320

atgaagatcc tgactctcgg gaagctgtcc cggaacaagg atgaagtgaa ggccatgatt     1380

gagaaactcg gggggaagtt gacggggacg gccaacaagg cttccctgtg catcagcacc     1440

aaaaaggagg tggaaaagat gaataagaag atggaggaag taaaggaagc caacatccga     1500

gttgtgtctg aggacttcct ccaggacgtc tccgcctcca ccaagagcct tcaggagttg     1560

ttcttagcgc acatcttgtc cccttggggg gcagaggtga aggcagagcc tgttgaagtt     1620

gtggccccaa gagggaagtc aggggctgcg ctctccaaaa aaagcaaggg ccaggtcaag     1680

gaggaaggta tcaacaaatc tgaaaagaga atgaaattaa ctcttaaagg aggagcagct     1740

gtggatcctg attctggact ggaacactct gcgcatgtcc tggagaaagg tgggaaggtc     1800

ttcagtgcca cccttggcct ggtggacatc gttaaaggaa ccaactccta ctacaagctg     1860

cagcttctgg aggacgacaa ggaaaacagg tattggatat tcaggtcctg gggccgtgtg     1920

ggtacggtga tcggtagcaa caaactggaa cagatgccgt ccaaggagga tgccattgag     1980

cacttcatga aattatatga agaaaaaacc gggaacgctt ggcactccaa aaatttcacg     2040

aagtatccca aaaagttcta ccccctggag attgactatg gccaggatga agaggcagtg     2100

aagaagctga cagtaaatcc tggcaccaag tccaagctcc ccaagccagt tcaggacctc     2160

atcaagatga tctttgatgt ggaaagtatg aagaaagcca tggtggagta tgagatcgac     2220

cttcagaaga tgcccttggg gaagctgagc aaaaggcaga tccaggccgc atactccatc     2280

ctcagtgagg tccagcaggc ggtgtctcag ggcagcagcg actctcagat cctggatctc     2340

tcaaatcgct tttacaccct gatcccccac gactttggga tgaagaagcc tccgctcctg     2400

aacaatgcag acagtgtgca ggccaaggcg gaaatgcttg acaacctgct ggacatcgag     2460

gtggcctaca gtctgctcag gggagggtct gatgatagca gcaaggatcc catcgatgtc     2520

aactatgaga agctcaaaac tgacattaag gtggttgaca gagattctga agaagccgag     2580

atcatcagga agtatgttaa gaacactcat gcaaccacac acaatgcgta tgacttggaa     2640

gtcatcgata tctttaagat agagcgtgaa ggcgaatgcc agcgttacaa gccctttaag     2700

cagcttcata accgaagatt gctgtggcac gggtccagga ccaccaactt tgctgggatc     2760

ctgtcccagg gtcttcggat agccccgcct gaagcgcccg tgacaggcta catgtttggt     2820

aaagggatct atttcgctga catggtctcc aagagtgcca actactgcca tacgtctcag     2880

ggagacccaa taggcttaat cctgttggga gaagttgccc ttggaaacat gtatgaactg     2940

aagcacgctt cacatatcag caagttaccc aagggcaagc acagtgtcaa aggtttgggc     3000

aaaactaccc ctgatccttc agctaacatt agtctggatg gtgtagacgt tcctcttggg     3060

accgggattt catctggtgt gaatgacacc tctctactat ataacgagta cattgtctat     3120

gatattgctc aggtaaatct gaagtatctg ctgaaactga aattcaattt taagacctcc     3180

ctgtggtaat tgggagaggt agccgagtca cacccggtgg ctctggtatg aattcacccg     3240

aagcgcttct gcaccaactc acctggccgc taagttgctg atgggtagta cctgtactaa     3300

accacctcag aaaggatttt acagaaacgt gttaaaggtt ttctctaact tctcaagtcc     3360

cttgttttgt gttgtgtctg tggggagggg ttgttttggg gttgtttttg ttttttcttg     3420

ccaggtagat aaaactgaca tagagaaaag gctggagaga gattctgttg catagactag     3480

tcctatggaa aaaaccaagc ttcgttagaa tgtctgcctt actggtttcc ccagggaagg     3540

aaaaatacac ttccaccctt ttttctaagt gttcgtcttt agttttgatt ttggaaagat     3600

gttaagcatt tatttttagt taaaaataaa aactaatttc atactattta aaaaaaaaaa     3660

aaaaaaaaaa aaaaaaa                                                    3677


<210>  3
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Phe Gly Ser Asp Leu Lys Asn Ser His Glu Ala Val Leu Lys 
1               5                   10                  15      


Leu Gln Asp Trp Glu Leu Arg Leu Leu Glu Thr Val Lys Lys Phe Met 
            20                  25                  30          


Ala Leu Arg Ile Lys Ser Asp Lys Glu Tyr Ala Ser Thr Leu Gln Asn 
        35                  40                  45              


Leu Cys Asn Gln Val Asp Lys Glu Ser Thr Val Gln Met Asn Tyr Val 
    50                  55                  60                  


Ser Asn Val Ser Lys Ser Trp Leu Leu Met Ile Gln Gln Thr Glu Gln 
65                  70                  75                  80  


Leu Ser Arg Ile Met Lys Thr His Ala Glu Asp Leu Asn Ser Gly Pro 
                85                  90                  95      


Leu His Arg Leu Thr Met Met Ile Lys Asp Lys Gln Gln Val Lys Lys 
            100                 105                 110         


Ser Tyr Ile Gly Val His Gln Gln Ile Glu Ala Glu Met Ile Lys Val 
        115                 120                 125             


Thr Lys Thr Glu Leu Glu Lys Leu Lys Cys Ser Tyr Arg Gln Leu Ile 
    130                 135                 140                 


Lys Glu Met Asn Ser Ala Lys Glu Lys Tyr Lys Glu Ala Leu Ala Lys 
145                 150                 155                 160 


Gly Lys Glu Thr Glu Lys Ala Lys Glu Arg Tyr Asp Lys Ala Thr Met 
                165                 170                 175     


Lys Leu His Met Leu His Asn Gln Tyr Val Leu Ala Leu Lys Gly Ala 
            180                 185                 190         


Gln Leu His Gln Asn Gln Tyr Tyr Asp Ile Thr Leu Pro Leu Leu Leu 
        195                 200                 205             


Asp Ser Leu Gln Lys Met Gln Glu Glu Met Ile Lys Ala Leu Lys Gly 
    210                 215                 220                 


Ile Phe Asp Glu Tyr Ser Gln Ile Thr Ser Leu Val Thr Glu Glu Ile 
225                 230                 235                 240 


Val Asn Val His Lys Glu Ile Gln Met Ser Val Glu Gln Ile Asp Pro 
                245                 250                 255     


Ser Thr Glu Tyr Asn Asn Phe Ile Asp Val His Arg Thr Thr Ala Ala 
            260                 265                 270         


Lys Glu Gln Glu Ile Glu Phe Asp Thr Ser Leu Leu Glu Glu Asn Glu 
        275                 280                 285             


Asn Leu Gln Ala Asn Glu Ile Met Trp Asn Asn Leu Thr Ala Glu Ser 
    290                 295                 300                 


Leu Gln Val Met Leu Lys Thr Leu Ala Glu Glu Leu Met Gln Thr Gln 
305                 310                 315                 320 


Gln Met Leu Leu Asn Lys Glu Glu Ala Val Leu Glu Leu Glu Lys Arg 
                325                 330                 335     


Ile Glu Glu Ser Ser Glu Thr Cys Glu Lys Lys Ser Asp Ile Val Leu 
            340                 345                 350         


Leu Leu Ser Gln Lys Gln Ala Leu Glu Glu Leu Lys Gln Ser Val Gln 
        355                 360                 365             


Gln Leu Arg Cys Thr Glu Ala Lys Phe Ser Ala Gln Lys Glu Leu Leu 
    370                 375                 380                 


Glu Gln Lys Val Gln Glu Asn Asp Gly Lys Glu Pro Pro Pro Val Val 
385                 390                 395                 400 


Asn Tyr Glu Glu Asp Ala Arg Ser Val Thr Ser Met Glu Arg Lys Glu 
                405                 410                 415     


Arg Leu Ser Lys Phe Glu Ser Ile Arg His Ser Ile Ala Gly Ile Ile 
            420                 425                 430         


Arg Ser Pro Lys Ser Ala Leu Gly Ser Ser Ala Leu Ser Asp Met Ile 
        435                 440                 445             


Ser Ile Ser Glu Lys Pro Leu Ala Glu Gln Asp Trp Tyr His Gly Ala 
    450                 455                 460                 


Ile Pro Arg Ile Glu Ala Gln Glu Leu Leu Lys Lys Gln Gly Asp Phe 
465                 470                 475                 480 


Leu Val Arg Glu Ser His Gly Lys Pro Gly Glu Tyr Val Leu Ser Val 
                485                 490                 495     


Tyr Ser Asp Gly Gln Arg Arg His Phe Ile Ile Gln Tyr Val Asp Asn 
            500                 505                 510         


Met Tyr Arg Phe Glu Gly Thr Gly Phe Ser Asn Ile Pro Gln Leu Ile 
        515                 520                 525             


Asp His His Tyr Thr Thr Lys Gln Val Ile Thr Lys Lys Ser Gly Val 
    530                 535                 540                 


Val Leu Leu Asn Pro Ile Pro Lys Asp Lys Lys Trp Ile Leu Ser His 
545                 550                 555                 560 


Glu Asp Val Ile Leu Gly Glu Leu Leu Gly Lys Gly Asn Phe Gly Glu 
                565                 570                 575     


Val Tyr Lys Gly Thr Leu Lys Asp Lys Thr Ser Val Ala Val Lys Thr 
            580                 585                 590         


Cys Lys Glu Asp Leu Pro Gln Glu Leu Lys Ile Lys Phe Leu Gln Glu 
        595                 600                 605             


Ala Lys Ile Leu Lys Gln Tyr Asp His Pro Asn Ile Val Lys Leu Ile 
    610                 615                 620                 


Gly Val Cys Thr Gln Arg Gln Pro Val Tyr Ile Ile Met Glu Leu Val 
625                 630                 635                 640 


Ser Gly Gly Asp Phe Leu Thr Phe Leu Arg Arg Lys Lys Asp Glu Leu 
                645                 650                 655     


Lys Leu Lys Gln Leu Val Lys Phe Ser Leu Asp Ala Ala Ala Gly Met 
            660                 665                 670         


Leu Tyr Leu Glu Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg 
        675                 680                 685             


Asn Cys Leu Val Gly Glu Asn Asn Val Leu Lys Ile Ser Asp Phe Gly 
    690                 695                 700                 


Met Ser Arg Gln Glu Asp Gly Gly Val Tyr Ser Ser Ser Gly Leu Lys 
705                 710                 715                 720 


Gln Ile Pro Ile Lys Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg 
                725                 730                 735     


Tyr Ser Ser Glu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu 
            740                 745                 750         


Thr Phe Ser Leu Gly Val Cys Pro Tyr Pro Gly Met Thr Asn Gln Gln 
        755                 760                 765             


Ala Arg Glu Gln Val Glu Arg Gly Tyr Arg Met Ser Ala Pro Gln His 
    770                 775                 780                 


Cys Pro Glu Asp Ile Ser Lys Ile Met Met Lys Cys Trp Asp Tyr Lys 
785                 790                 795                 800 


Pro Glu Asn Arg Pro Lys Phe Ser Glu Leu Gln Lys Glu Leu Thr Ile 
                805                 810                 815     


Ile Lys Arg Lys Leu Thr 
            820         


<210>  4
<211>  12134
<212>  DNA
<213>  Homo sapiens

<400>  4
gtcacaccct cgaataatga cgcataccta tcctactgtt actgatcacc tagtaataat       60

cttgtagttc acattactca tttttcacca aattcttttg gtgaaggacg cttcagaaac      120

ggccatcact gaagagcaga cccgtttggg ttctccacgc attctagact cccgaagagc      180

tcatgttttt tggctagacc tatgaccatt ttcgctagac ttcactgcac gttttctcaa      240

gtatcttctt tgtccctaat gtgtgacacc tcatcatgga cacgctactt tagctaaggc      300

atgaccagca atgaacagta gtaagatatg tgctgattag aaggctcact tgtgcagtgt      360

ggaggataac cagtgcctta caaaatgggg tttgggagtg acctgaagaa ttcacatgaa      420

gcagtgttaa aattgcaaga ctgggaatta cggttactgg aaacagtaaa gaaatttatg      480

gccctgagaa taaaaagtga taaagaatat gcatctactt tacagaacct ttgtaatcaa      540

gttgataagg aaagtactgt ccaaatgaat tatgtcagca acgtatccaa gtcttggcta      600

cttatgattc agcagacaga acaacttagt aggataatga agacacatgc agaggacttg      660

aactctggac ctttacacag gctcaccatg atgattaagg acaagcagca ggtgaagaaa      720

agttacatag gtgttcatca gcagatagag gcagagatga tcaaggttac caaaacagaa      780

ttggagaagt taaaatgcag ctatagacaa ttaataaaag aaatgaattc tgccaaagag      840

aaatataaag aagctttagc taaagggaag gaaactgaaa aggccaagga acgatacgac      900

aaagccacaa tgaaacttca tatgttgcac aatcagtatg tattggcgtt gaaaggggca      960

cagctccatc agaatcagta ttatgatatc acacttcccc tgcttctgga ctccttacaa     1020

aagatgcaag aagaaatgat aaaagcactc aaaggtatat ttgatgaata cagccagata     1080

accagtcttg tcacagagga aatagtgaat gtccataaag agattcaaat gtcggttgaa     1140

cagatagatc ctagtacaga atacaataat ttcatagatg ttcacagaac aacggctgct     1200

aaagaacaag aaatagagtt tgatacttcc ttactggaag aaaatgaaaa tcttcaggca     1260

aatgagatca tgtggaataa cttaacagca gaaagtttgc aagtaatgtt gaaaacgtta     1320

gcggaagaac ttatgcaaac acagcagatg cttttaaaca aggaggaggc tgttttggag     1380

ttagagaaga gaattgaaga atcttctgaa acttgtgaga agaagtctga tattgtgctt     1440

ctgctaagcc aaaaacaggc acttgaagaa ctgaaacagt cagtccagca gctgagatgc     1500

actgaagcaa agttttcagc acagaaggaa ttactagagc aaaaagtgca agaaaatgat     1560

gggaaagagc cacctccagt agtaaattat gaagaagatg cacgatcagt tacatctatg     1620

gaaagaaagg agaggctatc caaatttgaa tctattcgtc attcaattgc tggaataatt     1680

aggtctccaa aatctgcact gggctcttca gcactttctg atatgatctc catcagtgag     1740

aagcctttgg cagaacagga ctggtaccat ggtgcaattc ccagaataga agctcaagaa     1800

ctgttaaaaa aacaaggaga ctttttggtg cgagagagtc atgggaaacc tggtgaatat     1860

gtcctttctg tatattctga tggacagagg agacatttta tcatacaata tgttgataac     1920

atgtatcgat tcgagggcac tgggttttca aacattcctc aacttataga tcatcactat     1980

acaacaaaac aggtcatcac taagaaatca ggtgtagttc tgctgaatcc tattcctaag     2040

gacaagaaat ggattctcag tcatgaagat gtcatattgg gagaattact gggcaaggga     2100

aattttggtg aagtatataa gggcacatta aaggataaaa cttctgttgc tgttaaaaca     2160

tgtaaagaag atcttcctca ggaattgaaa ataaaatttt tacaagaagc caaaattctc     2220

aagcaatatg atcatcccaa tattgtcaaa cttataggag tttgcacaca aagacagcct     2280

gtctacatca ttatggaact ggtttcagga ggtgatttcc tcacctttct gagaaggaag     2340

aaggatgaac taaaactcaa acagttagtg aaattttcat tagacgctgc tgctggtatg     2400

ttgtatctcg agagtaaaaa ctgtatacac agggaccttg ctgcaagaaa ctgcctggta     2460

ggtgaaaata atgttctgaa aatcagtgac tttggaatgt ctcgtcaaga ggatggtgga     2520

gtgtattcat cttctggctt aaagcagatt cccattaaat ggacagcacc ggaagctctt     2580

aattatggga gatacagttc agagagtgac gtgtggagct ttggcatcct tctctgggag     2640

accttcagct taggggtttg tccgtaccct ggaatgacaa atcagcaagc aagagagcaa     2700

gtagaaagag gataccggat gtcagctccc cagcactgtc cagaggatat ttccaaaatc     2760

atgatgaagt gttgggatta taaacctgaa aatcgcccta agttcagtga acttcagaaa     2820

gagctcacta tcatcaagag aaaactcaca tagtgacagg atggcgccaa actcagcctt     2880

caggactctg tcctccagca gagtaacatt attgttctca ttaacaatga atttatacca     2940

cattaccttc gacagtcttc taccattatt ttttattaac tgggtgtttt aaaagtacgt     3000

tccacttgta aaaagtcaaa ggcaaatttg ttaaagaaat aggcagtcct accaagggct     3060

ttcttagcta accatagcaa tcctaccatt tcaggccatt gcaaatagaa aagcacaggc     3120

ttctaagtgt gtgaaggata aaagatctat cctatccttt tcacaccttg tttctacttc     3180

aggcacagtt tgtaggctgc catcctatgc cacagaccct actccgttgg tgctataaac     3240

agcattggta atgccatgtt tgcaggacat gttccaacca cagctggctt tcacctctgc     3300

caaagcagga ttatatttgt aaacaaacaa acagaatttt atattgggaa ttatttggac     3360

ctcctgagat ttttcttttc tttcttgcca ggtataagcc caatgtaaga atcatcatgc     3420

tcctacatta tttgtaaggt tgtcattttc ctcctccttt gtctgggcat cagaaaacaa     3480

tgcacgtagg tcgggcacgg tggctcacgc ctgtaatccc aggcatgtaa tctcatgcct     3540

gggattacag gcgtgagcca cagtgcccag ccccctccct cctttgggag gctgaggcag     3600

gcggatcacc tgaggtcagg agttcgagac cagcctggct tgcatggtga aaccctgtct     3660

ctaccaaaaa aaaaaaaaga aacacacaca caacgcatga aacgtcgtca aagttagagt     3720

tgaggcagtt gcttttcaag gatgtacaga gagctgtgaa gcaagaaaca gatttgaaca     3780

ggagggtggg ctggagaaca gagcagctaa agaatgatta acagagtaaa gaagaaagtg     3840

aaaatataaa accaccttat cagagttatg cctttctaaa catctaaaca aacaaacatt     3900

cacatattct attctaaaaa cacataataa tacatattct attttatggt ctgaatttac     3960

cagaaaggtc ctaagaaaag tttcaggagt tcgtagagtc ctcgtaatgg caacaaaaat     4020

tttgagagaa actgcaaagc acaaatccac agaaataaca gcatactttc agttaagcat     4080

tttcacctta gagggggcat tccaaaatgt aatttccttt atttgtacca gtttttagag     4140

ctgtcagaat ttcatgattc tagttcacca acacattcac gtgtgtacat gcgcgtgcac     4200

acacaccacc aaggtgcaag acagatgtga atgaagtaga cagtctagaa gtcaggtgaa     4260

tattaatgag aaatatgaca tagggacagc cctcccattt ctacttccac cttcattgac     4320

cattatactg ccccctggac attcttacca ttagctgaca ggtatgcaag cagagtgctg     4380

aagatgtctc atgtgaataa aatgtaactc actcactcag ttaaaactag gattctgtat     4440

cttaactctt atctagggaa cttacttact taccccatga tctgtatata gttgcctctc     4500

aggataaatg catatataga agatggtcat gctcagggct aaatatgttc tggaagcctt     4560

ttataagttc tcaggcctgt gtcctggtaa acattacctt agtgattatt tggtctgcat     4620

tcattggaag agcttaggga tagaaaatgc ctcctgccct ctccagctgt ttgctgcctg     4680

taccatcgca cagaactcac accagtactt tagagtatga aagataatac tgaagagaaa     4740

agtgacttgt atctaacatt tcaatctcct tgcagatttc atacatactt aatgattagt     4800

acattcagac taaagggaaa tttcttttga tggcacgtac tatggtaaat caaagcgcaa     4860

actcagaagt gctatggtat tgaggcactt accaaccttc aaaagtaaga gtaaaatggg     4920

atattcctac cctttttttt agtatttcta agtgaatctc tgtaatattc tttgtctgtt     4980

taaagaaaac agcctcccat ctcatagtgg cttcatgcta agctctcagc aaggagagag     5040

aatgatggtt ttggctttag ttttatgaac aagacctaaa gcttaatcct gacattctgg     5100

tgttaagaat gaacacagca ttgatatttc acttatccag gctgttagaa tttgcagttc     5160

acatcattac tctgtgctta aatttaaaaa gcttttcaaa acatcgtgac atgtgtagca     5220

tttaaattcc attttattct ttgtcctaaa gcaggcagtg gtatagttca ggattaataa     5280

cttattggga gtctctcagt catatagaat attaaattta atatagtcac atgcattaag     5340

aaaaacttac gcaaacagtt tttcactgtt aattttgttg tgcttgaagc ataatttatt     5400

catcccttct gtcactgata attaattatt ggaattatat actttaggag gctaatccat     5460

gcccaggaag cacgaacata ctgttcagaa tgtgcaagtt gatgtaggga aaggaagatt     5520

cagaaatgta caaaatcctg tgatttgttt agtaagaaaa gagttgtaac caaaatttct     5580

tctggtccgg atgtaattag tccagtcaca aatctttgtg ttgttaatgg attattcaag     5640

atatatatat atattcttac tactgcatag ttcctctcat aagtccttaa atttattaaa     5700

agggggaggt aaacacaagc agtctgtgtc tcactggtca ctaaggggcc tttatgagac     5760

agtttaggtt gttcatcatt tcacaaggaa agaaattttt cactgttaaa ttaacattta     5820

ttaccaacat gtgaaaccta aaattaattt tgcattccat gtaatctaag gccaaagcca     5880

acatattctt tctcttctgg gaaaataaaa ttgacaggtt ttgtttaaac ttcagaaact     5940

gaagctttat ttcagcctgt cctgccatga ggtctccagt gagaggtctc cagtgaaagg     6000

tctcatgtaa ttgtttctct tttatctccc aaatttaatg tgggcaataa aattctcctt     6060

tcgtaattca ctgttttatt acaaatacga tattactgaa acatcttatt agcagataag     6120

tatagaccag gagcctaact gtgttagata ttttcagtgc acatttcaca gttgtttttc     6180

attttaggat tattttgaga agaaaaaatg ttttgtaatt gaaatagttt taatttcctt     6240

taaaccataa tttggttttt ctatctatat tatattcagt tcagttttcc catataactt     6300

ttgtgaagat tggctagtac cacaaaataa ctatggcttc acaatactag tgttagatta     6360

tgtcaagaag aaagtgtttt agttacaaca tacgccaccc actgaggacc ttgtagtggg     6420

ataaacaaaa attaaaatgc aacaatccaa ataaattata atgtaacaat acaaatatct     6480

gaatcataag tcacagtttt tcagggttct ttcagtcaca ccactttata attaattctg     6540

gtgagtcatc agatgtagga atgtacctga aaaccttact tagtatactg tgtacactgt     6600

ttaatggcca tgcatctttt gaagtttgat attttctgaa aaagcattgt ttgcctcagc     6660

cctcttcttt ttacgtatac tccatttatc attgatattt tagatgtttc ttatcaacaa     6720

aattggctgc cctggttagt gctgagtcat cgcaagactt gcttttgcat ttaggaagcc     6780

acaccctccc acaaaacaga acagtgcaaa ataagcagca gagagacaga cagttggaaa     6840

agacatgttt tctttaggta ttaatatctt aattaaatgg aatcagattt tgtatggaaa     6900

tgagtttata ttacatttcc attatactaa gtcagtgtga aagtttacca tcaaaatagc     6960

gttacttctt ttatgactaa ctctgatttg cttatacata tcagaatgat attcattaaa     7020

tattttaatt tcatttattt ttctatgttt tgattagttt cacatcaagt ctgaatacta     7080

tattttggaa gaatccaaaa ccacatatga agatactgat tttaaaagtc aggatttcat     7140

gtaccaagaa tgacctactt gaaggagatt ttgctacact cttagagtcc caaaaattcc     7200

cctttaaaaa aaatgctgtc ctacagaagg tgtataaact ataccttagc cataattcaa     7260

tttaatgaaa tactacccca ttaaaagcca tcctcctgcc tcataccgat tcagaaatta     7320

aattctgaac ttttagtgta ggcattagga atcacttagc cacttaataa ggactgagat     7380

tcttgggtgg cagaaaaatc ctggtgtgct agattcttag tcactttaaa ctgcatagaa     7440

gtaatgagca taggcttcag tatatttaat aaggtgctga ggcagcagat tcaaatgcaa     7500

aagagggagg aaccagttat tccaaggcag gatgatgcac ccccacacag agtgtggaaa     7560

aattaaagtg aaacaaagat ttggacagtg tcattaggaa gcctgaggag aacatgctac     7620

aaggccagat cctgtcctat ggaaaataaa aaagatcagc agaactaaag caaaagcagt     7680

catctccagt gtgtgggcct tagcaaagag taaaccaaat acctctcctt gtgttaggag     7740

cactgttata ttcccagctc agagatgatt gtgtgctggg aaatgcttat attcattatt     7800

tcccaactaa tgcatttgga catatgtatt ccagtttttc aaagacacta cccaaagctt     7860

ctttacattt gcattggtta tatttaatat ttcttaagct aagatcactg attatccaca     7920

cgttattaga aatctttggt tacagtgagg cttaacctgg gctaaagtct cctaaatggg     7980

actacactta gatccgccct atttcacctt tggactaacg ttgactaaat ggctcctaga     8040

gttacccaca gagggagctt actatgatga gagctactgt ggggaaacat agtattcaac     8100

agagaaatgg aagaatacaa gtagcaatgt tccttgtctt caataacatt tgagggaaag     8160

gaatctagaa atcctaaagc ttagtcaggg tgcctaaggt aagacacaaa aagaaagaga     8220

catccagaaa ggaaggttga aaggaaatga agggcagtaa caaagcacca atgtaaaatg     8280

acccatagcc aacaataaat gcaataacaa taaaggaaac taaccctcac aaagggtttg     8340

aggagcttcc tgctgtgtgt ccttaaacag tgcgtgcctc ttaagtctct acaacacttt     8400

tttaaagggc attgaattgg acattggttt aatttttacc tacgctccct ataatctcag     8460

gaggtaacca ttatttaatc agaattaccc ttgctctgtt tatctgtgag gcctcagaca     8520

caacggtggt tcagccctct ccctaagcag tagcaagctg agtaatggca cacatatgtc     8580

taggatagcc agcattcagg aaaattgctg tgaacctcct gtttttaatt ttaatataga     8640

aaaagtcttt caggtttgtg acacgaagac agatttagct tcccacttgt cagcaaattt     8700

gtaaaaacct caaaacaaat gaatatttgg aattcactct aagagataca aatcctgaat     8760

ttctaactat cttctcaaat attactgagg ccagcaagat gcaagtgttc tacaaaataa     8820

tgaactgttc taagtgacag tgttgatgct ggaagtggaa tgttatgttt tcgctcagct     8880

gtattcattc agaaagtttt tcttgaacat ctgccacatg aggtgcagag aatactacca     8940

ggtgctagtt tttccagtat ttgacttctg attactattt ccttttctca tctttagttt     9000

ttcaagattt tgctttacca aaatagtaaa gcctttatca tcagcttata ttgaataatg     9060

ttgtaattgg tttcaatcaa agtttctcct caggtacttg ggggccccta gccttctaag     9120

gaactcccag gcacctactt aacaaggcca gctacacact cagtatgtga taagccccat     9180

gatggatgca ggttagaatt caaagacctg gttggagtcc tagatgtgga gacaggatga     9240

tcaggtcaca cttgttagat gactaacact atcagtagaa gctcttgaga gattttccta     9300

acgcagcaag atttctgtga gtagaggtat cctgggaggt atcctgggag gcagcctatt     9360

gacttgacca agtaagctga tcaggtggcc tcctctaccc actaaagaaa tgtgtaaaca     9420

ctagcaataa ttgctttatc ttaaactcct ggacatactc agttcttcca ttccactgtt     9480

ctattgccaa taccttttgt tgttttcttc acactcctct tggcagcaaa tgtctgaaag     9540

tatttcaatt gtgtaatgtt aaggagtttt ttcatagctt cagaaaagag ggcagcaaat     9600

atgaagcctt aagttcaaaa taagtcattc tacctagaaa tacagacccc agagcacatt     9660

gcatgaaaat acctgtactc tgcagttcct caaagcagta ttcttcctga aaagccaaac     9720

accacaccta ttttcctatt tgctaagaat cagaataagc acgttgtaaa tagtatccaa     9780

agcagattct aaaatgacat agtaagaagc cagattcaaa ttgtaaccaa agaagacaat     9840

agaaatccca ctttacccca ctgtcatcag ttagaacacc cttgcaaaaa ctgtaaccac     9900

ttaagcaatt catctgatcc cagaagatca taccttcttt tgaaagtata ggacagatat     9960

cagtgggaaa cgtcggcgtt ctgagcaaca caggataaat gtaggagggc cttaaaaaat    10020

aaatctcaat tcatacactg gagcagcaaa aaactgagca ggaaaggaaa cagaatccaa    10080

agtcattttt catatagctg ttgtcaaata gtataacctt ggtgtcttct ttgagttgcc    10140

tggacagtat ttatgaaaca aaaaactaaa tgccccccat ttggggacgg ggggaggggt    10200

tcagacctct aacctggatt cagagcctta gaggccgaga gggaatctgg aatctggtat    10260

tactgagatc ctaggtaaaa gaaccagcct ggcagtcttt cccacctcat tggtccgtgc    10320

ttttattttt aaacccaaaa gaaagaaaga aacacaccct cttatgtagg aatttccctt    10380

ttacaaataa tttgacctgg tagaaataaa cttgcctgcc tgctcttaaa tgccagacag    10440

ttggaagcaa atgccgaggg aaaggtgccc agagccatgc ttgataggac tttgaatatt    10500

ttctccttaa ttaaagtacg ttgcttgtat ttagactata agatgctatg gaggtctatc    10560

ccatgccatg ccaatgtgaa ttgctttgct tcagtaacaa tcagaagacc agtccaacag    10620

aaaataactt gtcataattc caccttagat tctagacctc tcatacctgc agtgtacaga    10680

atatgtacat gttccaatgg aattcactat ttttggcttt agtgtcaaag agattggttc    10740

tacaaggttc atctgatttc ccataacaag taaattttat aatcctatga ttctaaattc    10800

aatccccaat atagattcta agcatcaaat caaaatcaca gacaaagggg aactggtcga    10860

gaggggtctt agttatttca aatccatgac caaagtgtcc aaagacatga aactcttata    10920

cctgctgagc atttcacttt actatacaaa atgtcagcta cccagttgca tcctgtgaca    10980

tgatcagact gtcaatgtgg accagtggcc aggagcatat ttatgggcca tttctgttca    11040

tcattcttta cagagcattg aggtttccca ctgaaacagc ttctttagtc agacgtctat    11100

agattttaca taaatttaca tttaaatgca ttaagttaga tggcccaatt gagcatctga    11160

atgaatatag tgggggttgg tggtggtgca aattctgctg gctttatgtt atggttttct    11220

tcgtgttttt tcttggtttt gtctggcttc ttctggcaag tgccctaaaa gactggaaca    11280

ctgtataaag tcatagacat agaaccatat gggaaagccc agatgaaaaa atggaagaat    11340

aaaatcaagt tgtcaaagtt ccagcaacag ccctgacttc ttcaggaatc caagcaaatt    11400

gaaagccaag acaaaatgta caaatggtgc ccatgccatt catttgactg tgggtggccc    11460

tctagtctag ggctctctta gtgaatggtt gtggaaatat gatttttcta agttccttcc    11520

ttttcctttt gatagatgag tttgagatga tggagtagga gtggggccct caggcacttc    11580

tggtaaagac attccacctg caagcagcat tttgagtaaa gcactgctgt ggtttgccga    11640

tttatggtcc atttaatgtt aggctaaagc acctttaatc atttttgttg ttttaagata    11700

atgtatttgt gaagtggata aacactggaa atagggtgct tcttctggaa agttcagtgt    11760

aaaacacaaa caaggctttg gcgggtttat ctggctttat aaacaagtct gaaaaatgga    11820

tgaaagctaa atatataaag cagttggttg tctatctttt atcattttta ctcagatctg    11880

tatttaacac ttatttattt gttagttttt acattcaaaa gaaatacact ttgaactttg    11940

gctaacattg taggatattt tttaattgtt tctacatttt taaagcatga ttcatcattt    12000

ttgtaaactt agatcatttt ttaattgtct tttcttttcc aatagaccag ttaccactca    12060

tgtgtctgca gaacctcttt attgtattcc tataataaat gtaaaatatt tgtagcaaaa    12120

aaaaaaaaaa aaaa                                                      12134


<210>  5
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Gln Lys Met Lys Cys Pro His Cys Lys Asp Gln Leu Glu Ser 
1               5                   10                  15      


Gly Phe Gly Ser Gln Ser Cys Lys Thr Cys Ala Leu Met Phe Ser Ser 
            20                  25                  30          


Glu Pro Ser Thr Ser Glu Val His Arg Asp Gln Glu Arg Lys Glu Arg 
        35                  40                  45              


Leu Ser Lys Phe Glu Ser Ile Arg His Ser Ile Ala Gly Ile Ile Arg 
    50                  55                  60                  


Ser Pro Lys Ser Ala Leu Gly Ser Ser Ala Leu Ser Asp Met Ile Ser 
65                  70                  75                  80  


Ile Ser Glu Lys Pro Leu Ala Glu Gln Asp Trp Tyr His Gly Ala Ile 
                85                  90                  95      


Pro Arg Ile Glu Ala Gln Glu Leu Leu Lys Lys Gln Gly Asp Phe Leu 
            100                 105                 110         


Val Arg Glu Ser His Gly Lys Pro Gly Glu Tyr Val Leu Ser Val Tyr 
        115                 120                 125             


Ser Asp Gly Gln Arg Arg His Phe Ile Ile Gln Tyr Val Asp Asn Met 
    130                 135                 140                 


Tyr Arg Phe Glu Gly Thr Gly Phe Ser Asn Ile Pro Gln Leu Ile Asp 
145                 150                 155                 160 


His His Tyr Thr Thr Lys Gln Val Ile Thr Lys Lys Ser Gly Val Val 
                165                 170                 175     


Leu Leu Asn Pro Ile Pro Lys Asp Lys Lys Trp Ile Leu Ser His Glu 
            180                 185                 190         


Asp Val Ile Leu Gly Glu Leu Leu Gly Lys Gly Asn Phe Gly Glu Val 
        195                 200                 205             


Tyr Lys Gly Thr Leu Lys Asp Lys Thr Ser Val Ala Val Lys Thr Cys 
    210                 215                 220                 


Lys Glu Asp Leu Pro Gln Glu Leu Lys Ile Lys Phe Leu Gln Glu Ala 
225                 230                 235                 240 


Lys Ile Leu Lys Gln Tyr Asp His Pro Asn Ile Val Lys Leu Ile Gly 
                245                 250                 255     


Val Cys Thr Gln Arg Gln Pro Val Tyr Ile Ile Met Glu Leu Val Ser 
            260                 265                 270         


Gly Gly Asp Phe Leu Thr Phe Leu Arg Arg Lys Lys Asp Glu Leu Lys 
        275                 280                 285             


Leu Lys Gln Leu Val Lys Phe Ser Leu Asp Ala Ala Ala Gly Met Leu 
    290                 295                 300                 


Tyr Leu Glu Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn 
305                 310                 315                 320 


Cys Leu Val Gly Glu Asn Asn Val Leu Lys Ile Ser Asp Phe Gly Met 
                325                 330                 335     


Ser Arg Gln Glu Asp Gly Gly Val Tyr Ser Ser Ser Gly Leu Lys Gln 
            340                 345                 350         


Ile Pro Ile Lys Trp Thr Ala Pro Glu Ala Leu Asn Tyr Gly Arg Tyr 
        355                 360                 365             


Ser Ser Glu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Thr 
    370                 375                 380                 


Phe Ser Leu Gly Val Cys Pro Tyr Pro Gly Met Thr Asn Gln Gln Ala 
385                 390                 395                 400 


Arg Glu Gln Val Glu Arg Gly Tyr Arg Met Ser Ala Pro Gln His Cys 
                405                 410                 415     


Pro Glu Asp Ile Ser Lys Ile Met Met Lys Cys Trp Asp Tyr Lys Pro 
            420                 425                 430         


Glu Asn Arg Pro Lys Phe Ser Glu Leu Gln Lys Glu Leu Thr Ile Ile 
        435                 440                 445             


Lys Arg Lys Leu Thr 
    450             


<210>  6
<211>  1420
<212>  DNA
<213>  Homo sapiens

<400>  6
ttggtaaatt gacttccttg ggcccactgt cactatctct tagctaaatt ttgagatgga       60

gcagaaaatg aaatgtcctc attgtaagga tcagctggag tctggtttcg gctcccaatc      120

ctgtaaaaca tgtgctttaa tgttcagctc tgagccttcc acatcagaag tccacagaga      180

tcaggagaga aaggagaggc tatccaaatt tgaatctatt cgccattcaa ttgctggaat      240

aattaggtct ccaaaatctg cactgggctc ttcagcactt tctgatttga tctccatcag      300

tgagaagcct ttggcagaac aggactggta ccatggtgca attcccagaa tagaagctca      360

agaactgtta aaaaaacaag gagacttttt ggtgcgagag ggtcatggga aacctggtga      420

acatgtcctt tctgtatatt ctgatggaca gaggagacat tttatcatac aatatgttga      480

taacatgtat cgattcgagg gcactgggtt ttcaaacatt cctcaactta tagatcatca      540

ctatacaaca aaacaggtca tcactaagaa atcaggtgta gttctgctga atcctattcc      600

taaggacaag aaatggattt tcagtcatga agatgtcata ttgggagaat tactgggcaa      660

aggaaatttt ggtgaagtat ataagggcac attaaaggac aaaacttctg ttgctgttaa      720

aacatgtaaa gaagatcttc ctcaggaatt gaaaataaaa tttttacaag aagccaaaat      780

tctcaagcaa tatgatcatc ccaatattgt caaacttata ggagtttgca cacaaagaca      840

gcctgtctac atcattatgg aactggtttc aggaggtgat ttcctcacct ttctgagaag      900

gaagaaggat gaactaaaac tcaaacagtt agtgaaattt tcattggacg ctgctgctgg      960

tatgttgtat ctcgagagta aaaactgtat acacagggac cttgctgcaa gaaactgcct     1020

ggtaggtgaa aataatgttc tgaaaatcag tgactttgga atgtctcgtc aagaggatgg     1080

tggagtgtat tcatcttctg gcttaaagca gattcccatt aaatggacag caccggaagc     1140

tcttaattat gggagataca gttcagagag tgacgtgtgg agctttggca tccttctctg     1200

ggagaccttc agcttagggg tttgtccgta ccccggaatg acaaatcagc aagcaagaga     1260

gcaagtagaa agaggatacc ggatgtcagc tccccagcac tgtccagagg atatttccaa     1320

aatcatgatg aagtgttggg attataaacc tgaaaatcgc cctaagttca gtgaacttca     1380

gaaagagctc actatcatca agagaaaact cacatagtga                           1420


<210>  7
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Residues 447-820 of human Fer

<400>  7

Met Ile Ser Ile Ser Glu Lys Pro Leu Ala Glu Gln Asp Trp Tyr His 
1               5                   10                  15      


Gly Ala Ile Pro Arg Ile Glu Ala Gln Glu Leu Leu Lys Lys Gln Gly 
            20                  25                  30          


Asp Phe Leu Val Arg Glu Ser His Gly Lys Pro Gly Glu Tyr Val Leu 
        35                  40                  45              


Ser Val Tyr Ser Asp Gly Gln Arg Arg His Phe Ile Ile Gln Tyr Val 
    50                  55                  60                  


Asp Asn Met Tyr Arg Phe Glu Gly Thr Gly Phe Ser Asn Ile Pro Gln 
65                  70                  75                  80  


Leu Ile Asp His His Tyr Thr Thr Lys Gln Val Ile Thr Lys Lys Ser 
                85                  90                  95      


Gly Val Val Leu Leu Asn Pro Ile Pro Lys Asp Lys Lys Trp Ile Leu 
            100                 105                 110         


Ser His Glu Asp Val Ile Leu Gly Glu Leu Leu Gly Lys Gly Asn Phe 
        115                 120                 125             


Gly Glu Val Tyr Lys Gly Thr Leu Lys Asp Lys Thr Ser Val Ala Val 
    130                 135                 140                 


Lys Thr Cys Lys Glu Asp Leu Pro Gln Glu Leu Lys Ile Lys Phe Leu 
145                 150                 155                 160 


Gln Glu Ala Lys Ile Leu Lys Gln Tyr Asp His Pro Asn Ile Val Lys 
                165                 170                 175     


Leu Ile Gly Val Cys Thr Gln Arg Gln Pro Val Tyr Ile Ile Met Glu 
            180                 185                 190         


Leu Val Ser Gly Gly Asp Phe Leu Thr Phe Leu Arg Arg Lys Lys Asp 
        195                 200                 205             


Glu Leu Lys Leu Lys Gln Leu Val Lys Phe Ser Leu Asp Ala Ala Ala 
    210                 215                 220                 


Gly Met Leu Tyr Leu Glu Ser Lys Asn Cys Ile His Arg Asp Leu Ala 
225                 230                 235                 240 


Ala Arg Asn Cys Leu Val Gly Glu Asn Asn Val Leu Lys Ile Ser Asp 
                245                 250                 255     


Phe Gly Met Ser Arg Gln Glu Asp Gly Gly Val Tyr Ser Ser Ser Gly 
            260                 265                 270         


Leu Lys Gln Ile Pro Ile Lys Trp Thr Ala Pro Glu Ala Leu Asn Tyr 
        275                 280                 285             


Gly Arg Tyr Ser Ser Glu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu 
    290                 295                 300                 


Trp Glu Thr Phe Ser Leu Gly Val Cys Pro Tyr Pro Gly Met Thr Asn 
305                 310                 315                 320 


Gln Gln Ala Arg Glu Gln Val Glu Arg Gly Tyr Arg Met Ser Ala Pro 
                325                 330                 335     


Gln His Cys Pro Glu Asp Ile Ser Lys Ile Met Met Lys Cys Trp Asp 
            340                 345                 350         


Tyr Lys Pro Glu Asn Arg Pro Lys Phe Ser Glu Leu Gln Lys Glu Leu 
        355                 360                 365             


Thr Ile Ile Lys Arg Lys 
    370                 


<210>  8
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Residues 540-822 of human Fer

<400>  8

Lys Lys Ser Gly Val Val Leu Leu Asn Pro Ile Pro Lys Asp Lys Lys 
1               5                   10                  15      


Trp Ile Leu Ser His Glu Asp Val Ile Leu Gly Glu Leu Leu Gly Lys 
            20                  25                  30          


Gly Asn Phe Gly Glu Val Tyr Lys Gly Thr Leu Lys Asp Lys Thr Ser 
        35                  40                  45              


Val Ala Val Lys Thr Cys Lys Glu Asp Leu Pro Gln Glu Leu Lys Ile 
    50                  55                  60                  


Lys Phe Leu Gln Glu Ala Lys Ile Leu Lys Gln Tyr Asp His Pro Asn 
65                  70                  75                  80  


Ile Val Lys Leu Ile Gly Val Cys Thr Gln Arg Gln Pro Val Tyr Ile 
                85                  90                  95      


Ile Met Glu Leu Val Ser Gly Gly Asp Phe Leu Thr Phe Leu Arg Arg 
            100                 105                 110         


Lys Lys Asp Glu Leu Lys Leu Lys Gln Leu Val Lys Phe Ser Leu Asp 
        115                 120                 125             


Ala Ala Ala Gly Met Leu Tyr Leu Glu Ser Lys Asn Cys Ile His Arg 
    130                 135                 140                 


Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn Asn Val Leu Lys 
145                 150                 155                 160 


Ile Ser Asp Phe Gly Met Ser Arg Gln Glu Asp Gly Gly Val Tyr Ser 
                165                 170                 175     


Ser Ser Gly Leu Lys Gln Ile Pro Ile Lys Trp Thr Ala Pro Glu Ala 
            180                 185                 190         


Leu Asn Tyr Gly Arg Tyr Ser Ser Glu Ser Asp Val Trp Ser Phe Gly 
        195                 200                 205             


Ile Leu Leu Trp Glu Thr Phe Ser Leu Gly Val Cys Pro Tyr Pro Gly 
    210                 215                 220                 


Met Thr Asn Gln Gln Ala Arg Glu Gln Val Glu Arg Gly Tyr Arg Met 
225                 230                 235                 240 


Ser Ala Pro Gln His Cys Pro Glu Asp Ile Ser Lys Ile Met Met Lys 
                245                 250                 255     


Cys Trp Asp Tyr Lys Pro Glu Asn Arg Pro Lys Phe Ser Glu Leu Gln 
            260                 265                 270         


Lys Glu Leu Thr Ile Ile Lys Arg Lys Leu Thr 
        275                 280             


<210>  9
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for Fer KD

<400>  9
gccgcgaatt cgaaatcagg tgtagttctg ct                                     32


<210>  10
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Backward primer for Fer KD

<400>  10
cgactgcggc cgcctatgtg agttttctct tgat                                   34


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA-fer

<400>  11
acguauccaa gucuuggcua cuuau                                             25


<210>  12
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA-fer

<400>  12
ggaauuacgg uuacuggaaa cagua                                             25


