               SEQUENCE LISTING

<110> FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI

<120> COMPOUNDS WITH ANTIFIBROTIC ACTIVITY

<130> FON1P8WO

<160> 41

<170> BiSSAP 1.3

<210> 1
<211> 14
<212> PRT
<213> Homo sapiens

<400> 1
Gln Tyr Ala Gly Glu Lys Arg Arg Pro Pro Tyr Arg Trp Phe 
1               5                   10                  

<210> 2
<211> 14
<212> PRT
<213> Homo sapiens

<400> 2
Arg Pro Pro Tyr Arg Trp Phe Val Met Gly Pro Pro Arg Ser 
1               5                   10                  

<210> 3
<211> 14
<212> PRT
<213> Homo sapiens

<400> 3
Asn Ala Leu Val Gln Gly His Lys Arg Trp Cys Leu Phe Pro 
1               5                   10                  

<210> 4
<211> 14
<212> PRT
<213> Homo sapiens

<400> 4
Lys Arg Trp Cys Leu Phe Pro Thr Ser Thr Pro Arg Glu Leu 
1               5                   10                  

<210> 5
<211> 14
<212> PRT
<213> Homo sapiens

<400> 5
Lys Pro Gly Glu Thr Val Phe Val Pro Gly Gly Trp Trp His 
1               5                   10                  

<210> 6
<211> 14
<212> PRT
<213> Homo sapiens

<400> 6
Val Pro Gly Gly Trp Trp His Val Val Leu Asn Leu Asp Thr 
1               5                   10                  

<210> 7
<211> 14
<212> PRT
<213> Homo sapiens

<400> 7
Val Val Leu Asn Leu Asp Thr Thr Ile Ala Ile Thr Gln Asn 
1               5                   10                  

<210> 8
<211> 14
<212> PRT
<213> Homo sapiens

<400> 8
Thr Ile Ala Ile Thr Gln Asn Phe Ala Ser Ser Thr Asn Phe 
1               5                   10                  

<210> 9
<211> 14
<212> PRT
<213> Homo sapiens

<400> 9
Met Asn His Lys Ser Lys Lys Arg Ile Arg Glu Ala Lys Arg 
1               5                   10                  

<210> 10
<211> 14
<212> PRT
<213> Homo sapiens

<400> 10
Arg Ile Arg Glu Ala Lys Arg Ser Ala Arg Pro Glu Leu Lys 
1               5                   10                  

<210> 11
<211> 14
<212> PRT
<213> Homo sapiens

<400> 11
Trp Thr Leu Glu Arg Leu Lys Arg Lys Tyr Arg Asn Gln Lys 
1               5                   10                  

<210> 12
<211> 14
<212> PRT
<213> Homo sapiens

<400> 12
Arg Lys Tyr Arg Asn Gln Lys Phe Lys Cys Gly Glu Asp Asn 
1               5                   10                  

<210> 13
<211> 14
<212> PRT
<213> Homo sapiens

<400> 13
Asp Gly Tyr Ser Val Lys Met Lys Met Lys Tyr Tyr Ile Glu 
1               5                   10                  

<210> 14
<211> 14
<212> PRT
<213> Homo sapiens

<400> 14
Lys Met Lys Tyr Tyr Ile Glu Tyr Met Glu Ser Thr Arg Asp 
1               5                   10                  

<210> 15
<211> 14
<212> PRT
<213> Homo sapiens

<400> 15
Asp Ser Ser Tyr Gly Glu His Pro Lys Arg Arg Lys Leu Leu 
1               5                   10                  

<210> 16
<211> 14
<212> PRT
<213> Homo sapiens

<400> 16
Pro Lys Arg Arg Lys Leu Leu Glu Asp Tyr Lys Val Pro Lys 
1               5                   10                  

<210> 17
<211> 14
<212> PRT
<213> Homo sapiens

<400> 17
Pro Val Val Trp His Lys Thr Val Arg Gly Arg Pro Lys Leu 
1               5                   10                  

<210> 18
<211> 14
<212> PRT
<213> Homo sapiens

<400> 18
Val Arg Gly Arg Pro Lys Leu Ser Arg Lys Trp Tyr Arg Ile 
1               5                   10                  

<210> 19
<211> 14
<212> PRT
<213> Homo sapiens

<400> 19
Ser Arg Lys Trp Tyr Arg Ile Leu Lys Gln Glu His Pro Glu 
1               5                   10                  

<210> 20
<211> 14
<212> PRT
<213> Homo sapiens

<400> 20
Ser Glu Gly Asp Gly Thr Val His Arg Arg Lys Lys Arg Arg 
1               5                   10                  

<210> 21
<211> 14
<212> PRT
<213> Homo sapiens

<400> 21
His Arg Arg Lys Lys Arg Arg Thr Cys Ser Met Val Gly Asn 
1               5                   10                  

<210> 22
<211> 194
<212> PRT
<213> Homo sapiens

<400> 22
Asn Ile Met Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Ile Leu Tyr Ser 
            20                  25                  30          
Ser Asn His Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asn Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Val Gln Ser Glu Asp Leu Ala Val Tyr Tyr Cys His Gln 
                85                  90                  95      
Tyr Leu Ser Ser Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         
Arg His 
        

<210> 23
<211> 205
<212> PRT
<213> Homo sapiens

<400> 23
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Arg Ser Gly Asn Thr Asp Tyr Asn Ala Val Phe Met 
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asp Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Lys Asn Phe Arg Tyr Asp Val Gly Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val 
        115                 120                 125             
Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr 
145                 150                 155                 160 
Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser 
            180                 185                 190         
Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Pro 
        195                 200                 205 

<210> 24
<211> 35
<212> DNA
<213> Homo sapiens

<400> 24
ctgcagaagc ttgcggaacc agctggcgac cccgc                                35


<210> 25
<211> 60
<212> DNA
<213> Homo sapiens

<400> 25
ctgcagtcta gaccttatcg tcatcgtcct tgtagtctct ccctcttacc gtcttgtgcc     60


<210> 26
<211> 61
<212> DNA
<213> Homo sapiens

<400> 26
tgcagcccaa gcttgggcca tggactacaa ggacgatgac gataagcacc ctaaaagaag     60

g                                                                     61


<210> 27
<211> 30
<212> DNA
<213> Homo sapiens

<400> 27
ctgcagtcta gaatctgctc aggggtgagc                                     30


<210> 28
<211> 62
<212> DNA
<213> Homo sapiens

<400> 28
ctgcagccca agcttgggcc atggactaca aggacgatga cgataagcac cctaaaagaa     60

gg                                                                    62


<210> 29
<211> 38
<212> DNA
<213> Homo sapiens

<400> 29
ctgcagtcta gaacctggag gagctgcgct ctttgctg                             38


<210> 30
<211> 14
<212> PRT
<213> Homo sapiens

<400> 30
Asn Ala Lys Val Glu Glu Pro Arg Gln Pro Leu Val Tyr Leu 
1               5                   10                  

<210> 31
<211> 13
<212> PRT
<213> Homo sapiens

<400> 31
Gly Thr Arg Ser Val Gly Asp His Pro Pro Met Gly His 
1               5                   10              

<210> 32
<211> 205
<212> PRT
<213> Homo sapiens

<400> 32
Gln Val Gln Met Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ser Tyr 
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Trp Arg Ser Gly Asn Thr Asp Tyr Asn Ala Val Phe Met 
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asp Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      
Lys Asn Phe Arg Tyr Asp Val Gly Ser Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val 
        115                 120                 125             
Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr 
145                 150                 155                 160 
Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser 
            180                 185                 190         
Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Pro 
        195                 200                 205 

<210> 33
<211> 7
<212> PRT
<213> Homo sapiens

<400> 33
Arg Ile Arg Glu Ala Lys Arg 
1               5           

<210> 34
<211> 7
<212> PRT
<213> Homo sapiens

<400> 34
Arg Lys Tyr Arg Asn Gln Lys 
1               5           

<210> 35
<211> 7
<212> PRT
<213> Homo sapiens

<400> 35
Lys Met Lys Tyr Tyr Ile Glu 
1               5           

<210> 36
<211> 7
<212> PRT
<213> Homo sapiens

<400> 36
Pro Lys Arg Arg Lys Leu Leu 
1               5           

<210> 37
<211> 7
<212> PRT
<213> Homo sapiens

<400> 37
Arg Pro Pro Tyr Arg Trp Phe 
1               5           

<210> 38
<211> 7
<212> PRT
<213> Homo sapiens

<400> 38
Lys Arg Trp Cys Leu Phe Pro 
1               5           

<210> 39
<211> 21
<212> PRT
<213> Homo sapiens

<400> 39
Val Pro Gly Gly Trp Trp His Val Val Leu Asn Leu Asp Thr Thr Ile 
1               5                   10                  15      
Ala Ile Thr Gln Asn 
            20      

<210> 40
<211> 14
<212> PRT
<213> Homo sapiens

<400> 40
Val Arg Gly Arg Pro Lys Leu Ser Arg Lys Trp Tyr Arg Ile 
1               5                   10                  

<210> 41
<211> 7
<212> PRT
<213> Homo sapiens

<400> 41
His Arg Arg Lys Lys Arg Arg 
1               5           

