                         SEQUENCE LISTING

<110>  apceth GmbH & Co. KG
 
<120>  GENETICALLY MODIFIED MESENCHYMAL STEM CELL EXPRESSING KLOTHO

<130>  XII 2004/15WO

<150>  EP 15156974.6
<151>  2015-02-27

<150>  EP 15185805.7
<151>  2015-09-18

<150>  EP 15191062.7
<151>  2015-10-22

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  3039
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtttctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gatacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggctgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaatg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940

tctttactgg ctttcatagc ttttctattt tttgcttcta ttatttctct ctcccttata     3000

ttttactact cgaagaaagg cagaagaagt tacaaatag                            3039


<210>  2
<211>  3072
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcccgcca gcgcccctcc aagaaggcct agacctcctc cacctagcct gagcctgctg       60

ctggtgctgc tgggactggg aggaagaagg ctgagagccg aacctgggga tggcgcccag      120

acatgggcca gattctctag accacccgcc cctgaagccg ccggactgtt tcagggaacc      180

ttccccgatg gcttcctgtg ggccgtggga tctgccgcct atcagactga agggggctgg      240

cagcagcacg gcaagggcgc ctctatctgg gacaccttca cccaccatcc tctggcccca      300

cccggcgaca gcagaaatgc ttctctgcct ctgggagccc ccagccctct gcagcctgct      360

acaggggatg tggccagcga cagctacaac aacgtgttcc gggacacaga ggccctgcgg      420

gaactgggcg tgacccacta cagattcagc atcagctggg ccagagtgct gcccaatggc      480

tctgccggcg tgcccaatag agagggcctg cggtactacc ggcggctgct ggaaagactg      540

agagaactgg gagtgcagcc cgtcgtgacc ctgtaccatt gggacctgcc ccagagactg      600

caggatgcct atggcggctg ggccaataga gccctggccg accacttcag agactacgcc      660

gagctgtgct tccggcactt tggcggccaa gtgaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctatgccaca ggcagactgg cccctggcat cagaggaagc      780

cctagactgg gctacctggt ggcccacaat ctgctgctgg cccacgctaa agtgtggcac      840

ctgtacaaca ccagcttccg gcctacacag ggcggccagg tgtccattgc cctgagcagc      900

cactggatca accccagacg gatgaccgac cacagcatca aagagtgcca gaaaagcctg      960

gacttcgtgc tgggatggtt cgccaagccc gtgttcatcg acggcgacta ccccgagagc     1020

atgaagaaca acctgtccag catcctgccc gacttcaccg agagcgagaa gaagttcatc     1080

aagggcaccg ccgatttctt cgccctgtgc ttcggcccta ccctgagctt ccagctgctg     1140

gacccccaca tgaagttcag acagctggaa agccccaacc tgcggcagct gctgagctgg     1200

atcgacctgg aattcaacca cccccagatt ttcatcgtgg aaaacggctg gttcgtgtcc     1260

ggcaccacca agagggacga cgccaagtac atgtattacc tgaaaaagtt tatcatggaa     1320

accctgaagg ccatcaagct ggacggcgtg gacgtgatcg gctacacagc ctggtccctg     1380

atggacggct tcgagtggca ccggggctac tctatcagac ggggcctgtt ctacgtggac     1440

ttcctgagcc aggacaagat gctgctgcct aagagcagcg ccctgtttta ccagaagctg     1500

atcgagaaga acggcttccc acccctgccc gagaaccagc ctctggaagg caccttcccc     1560

tgcgattttg cctggggcgt ggtggacaac tacatccagg tggacaccac cctgtcccag     1620

ttcaccgacc tgaacgtgta cctgtgggac gtgcaccaca gcaagcggct gattaaggtg     1680

gacggggtcg tgaccaagaa gcggaagtcc tactgcgtgg actttgccgc catccagccc     1740

cagattgccc tgctgcagga aatgcacgtg acacacttcc ggttctccct ggactgggcc     1800

ctgatcctgc cactgggcaa tcagagccaa gtgaaccaca ccattctgca gtactacaga     1860

tgcatggcct ccgagctggt gcgcgtgaac atcacacctg tggtggccct gtggcagccc     1920

atggccccta atcagggact gcctagactg ctggctagac agggcgcctg ggagaaccct     1980

tacaccgccc tggcctttgc cgagtacgcc cggctgtgtt tccaggaact ggggcaccac     2040

gtgaagctgt ggatcacaat gaacgagccc tacacccgga acatgaccta cagcgccgga     2100

cataacctgc tgaaggccca cgccctggct tggcatgtgt acaacgagaa gttccggcac     2160

gcccagaacg gcaagatcag tatcgccctg caggccgact ggatcgagcc cgcctgtccc     2220

ttcagccaga aagacaaaga ggtggccgag cgggtgctgg aattcgacat tggatggctg     2280

gccgagccca tcttcggcag cggcgattac ccctgggtca tgcgggactg gctgaaccag     2340

cggaacaact tcctgctgcc ttactttacc gaggatgaga agaaactgat ccaggggacc     2400

ttcgacttcc tggccctgag ccactacacc acaatcctgg tggacagcga gaaagaggac     2460

cccatcaagt acaacgacta cctggaagtg caggaaatga ccgacatcac ctggctgaat     2520

agcccctccc aggtggccgt ggtgccttgg ggactgagaa aggtgctgaa ttggctgaag     2580

tttaagtacg gcgacctgcc catgtacatc atcagcaacg gcatcgacga tggcctgcac     2640

gccgaggacg atcagctgcg ggtgtactac atgcagaact acatcaacga ggccctgaaa     2700

gcccacatcc tggacggcat caacctgtgc ggctacttcg cctacagctt caacgaccgg     2760

accgccccta gattcggcct gtacagatac gccgccgacc agttcgagcc caaggccagc     2820

atgaagcact accggaagat catcgacagc aatggcttcc ctggccccga gacactggaa     2880

cggttctgcc ccgaggaatt caccgtgtgt accgagtgca gcttcttcca caccagaaag     2940

tccctgctgg cttttatcgc cttcctgttc ttcgccagca tcatctccct gtccctgatc     3000

ttctactaca gcaagaaggg cagacggtcc tacaagtacc cctacgacgt gcccgactac     3060

gcctgatgat ga                                                         3072


<210>  3
<211>  1650
<212>  DNA
<213>  Homo sapiens

<400>  3
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgcagtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtttctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag taagtcagct gacaaaacca     1620

atcagcagtc tcaccaagcc ctatcactag                                      1650


<210>  4
<211>  3135
<212>  DNA
<213>  Homo sapiens

<400>  4
atgaagccag gctgtgcggc aggatctcca gggaatgaat ggattttctt cagcactgat       60

gaaataacca cacgctatag gaatacaatg tccaacgggg gattgcaaag atctgtcatc      120

ctgtcagcac ttattctgct acgagctgtt actggattct ctggagatgg aagagctata      180

tggtctaaaa atcctaattt tactccggta aatgaaagtc agctgtttct ctatgacact      240

ttccctaaaa actttttctg gggtattggg actggagcat tgcaagtgga agggagttgg      300

aagaaggatg gaaaaggacc ttctatatgg gatcatttca tccacacaca ccttaaaaat      360

gtcagcagca cgaatggttc cagtgacagt tatatttttc tggaaaaaga cttatcagcc      420

ctggatttta taggagtttc tttttatcaa ttttcaattt cctggccaag gcttttcccc      480

gatggaatag taacagttgc caacgcaaaa ggtctgcagt actacagtac tcttctggac      540

gctctagtgc ttagaaacat tgaacctata gttactttat accactggga tttgcctttg      600

gcactacaag aaaaatatgg ggggtggaaa aatgatacca taatagatat cttcaatgac      660

tatgccacat actgtttcca gatgtttggg gaccgtgtca aatattggat tacaattcac      720

aacccatatc tagtggcttg gcatgggtat gggacaggta tgcatgcccc tggagagaag      780

ggaaatttag cagctgtcta cactgtggga cacaacttga tcaaggctca ctcgaaagtt      840

tggcataact acaacacaca tttccgccca catcagaagg gttggttatc gatcacgttg      900

ggatctcatt ggatcgagcc aaaccggtcg gaaaacacga tggatatatt caaatgtcaa      960

caatccatgg tttctgtgct tggatggttt gccaacccta tccatgggga tggcgactat     1020

ccagagggga tgagaaagaa gttgttctcc gttctaccca ttttctctga agcagagaag     1080

catgagatga gaggcacagc tgatttcttt gccttttctt ttggacccaa caacttcaag     1140

cccctaaaca ccatggctaa aatgggacaa aatgtttcac ttaatttaag agaagcgctg     1200

aactggatta aactggaata caacaaccct cgaatcttga ttgctgagaa tggctggttc     1260

acagacagtc gtgtgaaaac agaagacacc acggccatct acatgatgaa gaatttcctc     1320

agccaggtgc ttcaagcaat aaggttagat gaaatacgag tgtttggtta tactgcctgg     1380

tctctcctgg atggctttga atggcaggat gcttacacca tccgccgagg attattttat     1440

gtggatttta acagtaaaca gaaagagcgg aaacctaagt cttcagcaca ctactacaaa     1500

cagatcatac gagaaaatgg tttttcttta aaagagtcca cgccagatgt gcagggccag     1560

tttccctgtg acttctcctg gggtgtcact gaatctgttc ttaagcccga gtctgtggct     1620

tcgtccccac agttcagcga tcctcatctg tacgtgtgga acgccactgg caacagactg     1680

ttgcaccgag tggaaggggt gaggctgaaa acacgacccg ctcaatgcac agattttgta     1740

aacatcaaaa aacaacttga gatgttggca agaatgaaag tcacccacta ccggtttgct     1800

ctggattggg cctcggtcct tcccactggc aacctgtccg cggtgaaccg acaggccctg     1860

aggtactaca ggtgcgtggt cagtgagggg ctgaagcttg gcatctccgc gatggtcacc     1920

ctgtattatc cgacccacgc ccacctaggc ctccccgagc ctctgttgca tgccgacggg     1980

tggctgaacc catcgacggc cgaggccttc caggcctacg ctgggctgtg cttccaggag     2040

ctgggggacc tggtgaagct ctggatcacc atcaacgagc ctaaccggct aagtgacatc     2100

tacaaccgct ctggcaacga cacctacggg gcggcgcaca acctgctggt ggcccacgcc     2160

ctggcctggc gcctctacga ccggcagttc aggccctcac agcgcggggc cgtgtcgctg     2220

tcgctgcacg cggactgggc ggaacccgcc aacccctatg ctgactcgca ctggagggcg     2280

gccgagcgct tcctgcagtt cgagatcgcc tggttcgccg agccgctctt caagaccggg     2340

gactaccccg cggccatgag ggaatacatt gcctccaagc accgacgggg gctttccagc     2400

tcggccctgc cgcgcctcac cgaggccgaa aggaggctgc tcaagggcac ggtcgacttc     2460

tgcgcgctca accacttcac cactaggttc gtgatgcacg agcagctggc cggcagccgc     2520

tacgactcgg acagggacat ccagtttctg caggacatca cccgcctgag ctcccccacg     2580

cgcctggctg tgattccctg gggggtgcgc aagctgctgc ggtgggtccg gaggaactac     2640

ggcgacatgg acatttacat caccgccagt ggcatcgacg accaggctct ggaggatgac     2700

cggctccgga agtactacct agggaagtac cttcaggagg tgctgaaagc atacctgatt     2760

gataaagtca gaatcaaagg ctattatgca ttcaaactgg ctgaagagaa atctaaaccc     2820

agatttggat tcttcacatc tgattttaaa gctaaatcct caatacaatt ttacaacaaa     2880

gtgatcagca gcaggggctt cccttttgag aacagtagtt ctagatgcag tcagacccaa     2940

gaaaatacag agtgcactgt ctgcttattc cttgtgcaga agaaaccact gatattcctg     3000

ggttgttgct tcttctccac cctggttcta ctcttatcaa ttgccatttt tcaaaggcag     3060

aagagaagaa agttttggaa agcaaaaaac ttacaacaca taccattaaa gaaaggcaag     3120

agagttgtta gctaa                                                      3135


<210>  5
<211>  1704
<212>  DNA
<213>  Homo sapiens

<400>  5
atgaagccag tgtgggtcgc cacccttctg tggatgctac tgctggtgcc caggctgggg       60

gccgcccgga aggggtcccc agaagaggcc tccttctact atggaacctt ccctcttggc      120

ttctcctggg gcgtgggcag ttctgcctac cagacggagg gcgcctggga ccaggacggg      180

aaagggccta gcatctggga cgtcttcaca cacagtggga aggggaaagt gcttgggaat      240

gagacggcag atgtagcctg tgacggctac tacaaggtcc aggaggacat cattctgctg      300

agggaactgc acgtcaacca ctaccgattc tccctgtctt ggccccggct cctgcccaca      360

ggcatccgag ccgagcaggt gaacaagaag ggaatcgaat tctacagtga tcttatcgat      420

gcccttctga gcagcaacat cactcccatc gtgaccttgc accactggga tctgccacag      480

ctgctccagg tcaaatacgg tgggtggcag aatgtgagca tggccaacta cttcagagac      540

tacgccaacc tgtgctttga ggcctttggg gaccgtgtga agcactggat cacgttcagt      600

gatcctcggg caatggcaga aaaaggctat gagacgggcc accatgcgcc gggcctgaag      660

ctccgcggca ccggcctgta caaggcagca caccacatca ttaaggccca cgccaaagcc      720

tggcattctt ataacaccac gtggcgcagc aagcagcaag gtctggtggg aatttcattg      780

aactgtgact ggggggaacc tgtggacatt agtaacccca aggacctaga ggctgccgag      840

agatacctac agttctgtct gggctggttt gccaacccca tttatgccgg tgactacccc      900

caagtcatga aggactacat tggaagaaag agtgcagagc aaggcctgga gatgtcgagg      960

ttaccggtgt tctcactcca ggagaagagc tacattaaag gcacatccga tttcttggga     1020

ttaggtcatt ttactactcg gtacatcacg gaaaggaact acccctcccg ccaggggccc     1080

agctaccaga acgatcgtga cttgatagag ctggttgacc caaactggcc agatctgggg     1140

tctaaatggc tatattctgt gccatgggga tttaggaggc tccttaactt tgctcagact     1200

caatacggtg atcctcccat atatgtgatg gaaaatggag catctcaaaa attccactgt     1260

actcaattat gtgatgagtg gagaattcaa taccttaaag gatacataaa tgaaatgcta     1320

aaagctataa aagatggtgc taatataaag gggtatactt cctggtctct gttggataag     1380

tttgaatggg agaaaggata ctcagataga tatggattct actatgttga atttaacgac     1440

agaaataagc ctcgctatcc aaaggcttca gttcaatatt acaagaagat tatcattgcc     1500

aatgggtttc ccaatccaag agaggtggaa agttggtacc tcaaagcttt ggaaacttgc     1560

tctatcaaca atcagatgct tgctgcagag cccttgctaa gtcacatgca aatggttacg     1620

gagatcgtgg tacccactgt ctgctccctc tgtgtcctca tcactgctgt tctactaatg     1680

ctcctcctga ggaggcagag ctga                                            1704


<210>  6
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  7
<211>  1021
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala 
    1010                 1015                 1020     


<210>  8
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Gln Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His 
545                 


<210>  9
<211>  1044
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln 
305                 310                 315                 320 


Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu 
            340                 345                 350         


Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp 
        355                 360                 365             


Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr 
    370                 375                 380                 


Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu 
385                 390                 395                 400 


Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu 
                405                 410                 415     


Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala 
            420                 425                 430         


Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg 
        435                 440                 445             


Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp 
    450                 455                 460                 


Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala 
                485                 490                 495     


His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu 
            500                 505                 510         


Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly 
        515                 520                 525             


Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln 
    530                 535                 540                 


Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu 
545                 550                 555                 560 


Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys 
                565                 570                 575     


Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met 
            580                 585                 590         


Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro 
        595                 600                 605             


Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg 
    610                 615                 620                 


Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr 
625                 630                 635                 640 


Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu 
                645                 650                 655     


His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala 
            660                 665                 670         


Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp 
        675                 680                 685             


Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser 
    690                 695                 700                 


Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala 
705                 710                 715                 720 


Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly 
                725                 730                 735     


Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro 
            740                 745                 750         


Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu 
        755                 760                 765             


Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala 
    770                 775                 780                 


Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser 
785                 790                 795                 800 


Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly 
                805                 810                 815     


Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met 
            820                 825                 830         


His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln 
        835                 840                 845             


Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val 
    850                 855                 860                 


Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr 
865                 870                 875                 880 


Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala 
                885                 890                 895     


Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln 
            900                 905                 910         


Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr 
        915                 920                 925             


Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe 
    930                 935                 940                 


Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys 
945                 950                 955                 960 


Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys 
                965                 970                 975     


Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val 
            980                 985                 990         


Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu 
        995                 1000                 1005             


Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg 
    1010                 1015                 1020             


Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys 
    1025                 1030                 1035             


Gly Lys  Arg Val Val Ser 
    1040                 


<210>  10
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Pro Val Trp Val Ala Thr Leu Leu Trp Met Leu Leu Leu Val 
1               5                   10                  15      


Pro Arg Leu Gly Ala Ala Arg Lys Gly Ser Pro Glu Glu Ala Ser Phe 
            20                  25                  30          


Tyr Tyr Gly Thr Phe Pro Leu Gly Phe Ser Trp Gly Val Gly Ser Ser 
        35                  40                  45              


Ala Tyr Gln Thr Glu Gly Ala Trp Asp Gln Asp Gly Lys Gly Pro Ser 
    50                  55                  60                  


Ile Trp Asp Val Phe Thr His Ser Gly Lys Gly Lys Val Leu Gly Asn 
65                  70                  75                  80  


Glu Thr Ala Asp Val Ala Cys Asp Gly Tyr Tyr Lys Val Gln Glu Asp 
                85                  90                  95      


Ile Ile Leu Leu Arg Glu Leu His Val Asn His Tyr Arg Phe Ser Leu 
            100                 105                 110         


Ser Trp Pro Arg Leu Leu Pro Thr Gly Ile Arg Ala Glu Gln Val Asn 
        115                 120                 125             


Lys Lys Gly Ile Glu Phe Tyr Ser Asp Leu Ile Asp Ala Leu Leu Ser 
    130                 135                 140                 


Ser Asn Ile Thr Pro Ile Val Thr Leu His His Trp Asp Leu Pro Gln 
145                 150                 155                 160 


Leu Leu Gln Val Lys Tyr Gly Gly Trp Gln Asn Val Ser Met Ala Asn 
                165                 170                 175     


Tyr Phe Arg Asp Tyr Ala Asn Leu Cys Phe Glu Ala Phe Gly Asp Arg 
            180                 185                 190         


Val Lys His Trp Ile Thr Phe Ser Asp Pro Arg Ala Met Ala Glu Lys 
        195                 200                 205             


Gly Tyr Glu Thr Gly His His Ala Pro Gly Leu Lys Leu Arg Gly Thr 
    210                 215                 220                 


Gly Leu Tyr Lys Ala Ala His His Ile Ile Lys Ala His Ala Lys Ala 
225                 230                 235                 240 


Trp His Ser Tyr Asn Thr Thr Trp Arg Ser Lys Gln Gln Gly Leu Val 
                245                 250                 255     


Gly Ile Ser Leu Asn Cys Asp Trp Gly Glu Pro Val Asp Ile Ser Asn 
            260                 265                 270         


Pro Lys Asp Leu Glu Ala Ala Glu Arg Tyr Leu Gln Phe Cys Leu Gly 
        275                 280                 285             


Trp Phe Ala Asn Pro Ile Tyr Ala Gly Asp Tyr Pro Gln Val Met Lys 
    290                 295                 300                 


Asp Tyr Ile Gly Arg Lys Ser Ala Glu Gln Gly Leu Glu Met Ser Arg 
305                 310                 315                 320 


Leu Pro Val Phe Ser Leu Gln Glu Lys Ser Tyr Ile Lys Gly Thr Ser 
                325                 330                 335     


Asp Phe Leu Gly Leu Gly His Phe Thr Thr Arg Tyr Ile Thr Glu Arg 
            340                 345                 350         


Asn Tyr Pro Ser Arg Gln Gly Pro Ser Tyr Gln Asn Asp Arg Asp Leu 
        355                 360                 365             


Ile Glu Leu Val Asp Pro Asn Trp Pro Asp Leu Gly Ser Lys Trp Leu 
    370                 375                 380                 


Tyr Ser Val Pro Trp Gly Phe Arg Arg Leu Leu Asn Phe Ala Gln Thr 
385                 390                 395                 400 


Gln Tyr Gly Asp Pro Pro Ile Tyr Val Met Glu Asn Gly Ala Ser Gln 
                405                 410                 415     


Lys Phe His Cys Thr Gln Leu Cys Asp Glu Trp Arg Ile Gln Tyr Leu 
            420                 425                 430         


Lys Gly Tyr Ile Asn Glu Met Leu Lys Ala Ile Lys Asp Gly Ala Asn 
        435                 440                 445             


Ile Lys Gly Tyr Thr Ser Trp Ser Leu Leu Asp Lys Phe Glu Trp Glu 
    450                 455                 460                 


Lys Gly Tyr Ser Asp Arg Tyr Gly Phe Tyr Tyr Val Glu Phe Asn Asp 
465                 470                 475                 480 


Arg Asn Lys Pro Arg Tyr Pro Lys Ala Ser Val Gln Tyr Tyr Lys Lys 
                485                 490                 495     


Ile Ile Ile Ala Asn Gly Phe Pro Asn Pro Arg Glu Val Glu Ser Trp 
            500                 505                 510         


Tyr Leu Lys Ala Leu Glu Thr Cys Ser Ile Asn Asn Gln Met Leu Ala 
        515                 520                 525             


Ala Glu Pro Leu Leu Ser His Met Gln Met Val Thr Glu Ile Val Val 
    530                 535                 540                 


Pro Thr Val Cys Ser Leu Cys Val Leu Ile Thr Ala Val Leu Leu Met 
545                 550                 555                 560 


Leu Leu Leu Arg Arg Gln Ser 
                565         


