                         SEQUENCE LISTING

<110>  UBO
       INSERM
       CHU Brest
 
<120>  Processes for the diagnosis, prognosis and monitoring of the 
       progression of Chronic Lymphoid Leukaemia (CLL) and/or of 
       Systemic Lupus Erythematosus (SLE) using membrane STIM 1

<130>  BNT218447PC00

<150>  EP15156694.0
<151>  2015-02-26

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Val Cys Val Arg Leu Ala Leu Trp Leu Leu Trp Gly Leu Leu 
1               5                   10                  15      


Leu His Gln Gly Gln Ser Leu Ser His Ser His Ser Glu Lys Ala Thr 
            20                  25                  30          


Gly Thr Ser Ser Gly Ala Asn Ser Glu Glu Ser Thr Ala Ala Glu Phe 
        35                  40                  45              


Cys Arg Ile Asp Lys Pro Leu Cys His Ser Glu Asp Glu Lys Leu Ser 
    50                  55                  60                  


Phe Glu Ala Val Arg Asn Ile His Lys Leu Met Asp Asp Asp Ala Asn 
65                  70                  75                  80  


Gly Asp Val Asp Val Glu Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu 
                85                  90                  95      


Asn Tyr His Asp Pro Thr Val Lys His Ser Thr Phe His Gly Glu Asp 
            100                 105                 110         


Lys Leu Ile Ser Val Glu Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu 
        115                 120                 125             


Val Tyr Asn Trp Thr Val Asp Glu Val Val Gln Trp Leu Ile Thr Tyr 
    130                 135                 140                 


Val Glu Leu Pro Gln Tyr Glu Glu Thr Phe Arg Lys Leu Gln Leu Ser 
145                 150                 155                 160 


Gly His Ala Met Pro Arg Leu Ala Val Thr Asn Thr Thr Met Thr Gly 
                165                 170                 175     


Thr Val Leu Lys Met Thr Asp Arg Ser His Arg Gln Lys Leu Gln Leu 
            180                 185                 190         


Lys Ala Leu Asp Thr Val Leu Phe Gly Pro Pro Leu Leu Thr Arg His 
        195                 200                 205             


Asn His Leu Lys Asp Phe Met Leu Val Val Ser Ile Val Ile Gly Val 
    210                 215                 220                 


Gly Gly Cys Trp Phe Ala Tyr Ile Gln Asn Arg Tyr Ser Lys Glu His 
225                 230                 235                 240 


Met Lys Lys Met Met Lys Asp Leu Glu Gly Leu His Arg Ala Glu Gln 
                245                 250                 255     


Ser Leu His Asp Leu Gln Glu Arg Leu His Lys Ala Gln Glu Glu His 
            260                 265                 270         


Arg Thr Val Glu Val Glu Lys Val His Leu Glu Lys Lys Leu Arg Asp 
        275                 280                 285             


Glu Ile Asn Leu Ala Lys Gln Glu Ala Gln Arg Leu Lys Glu Leu Arg 
    290                 295                 300                 


Glu Gly Thr Glu Asn Glu Arg Ser Arg Gln Lys Tyr Ala Glu Glu Glu 
305                 310                 315                 320 


Leu Glu Gln Val Arg Glu Ala Leu Arg Lys Ala Glu Lys Glu Leu Glu 
                325                 330                 335     


Ser His Ser Ser Trp Tyr Ala Pro Glu Ala Leu Gln Lys Trp Leu Gln 
            340                 345                 350         


Leu Thr His Glu Val Glu Val Gln Tyr Tyr Asn Ile Lys Lys Gln Asn 
        355                 360                 365             


Ala Glu Lys Gln Leu Leu Val Ala Lys Glu Gly Ala Glu Lys Ile Lys 
    370                 375                 380                 


Lys Lys Arg Asn Thr Leu Phe Gly Thr Phe His Val Ala His Ser Ser 
385                 390                 395                 400 


Ser Leu Asp Asp Val Asp His Lys Ile Leu Thr Ala Lys Gln Ala Leu 
                405                 410                 415     


Ser Glu Val Thr Ala Ala Leu Arg Glu Arg Leu His Arg Trp Gln Gln 
            420                 425                 430         


Ile Glu Ile Leu Cys Gly Phe Gln Ile Val Asn Asn Pro Gly Ile His 
        435                 440                 445             


Ser Leu Val Ala Ala Leu Asn Ile Asp Pro Ser Trp Met Gly Ser Thr 
    450                 455                 460                 


Arg Pro Asn Pro Ala His Phe Ile Met Thr Asp Asp Val Asp Asp Met 
465                 470                 475                 480 


Asp Glu Glu Ile Val Ser Pro Leu Ser Met Gln Ser Pro Ser Leu Gln 
                485                 490                 495     


Ser Ser Val Arg Gln Arg Leu Thr Glu Pro Gln His Gly Leu Gly Ser 
            500                 505                 510         


Gln Arg Asp Leu Thr His Ser Asp Ser Glu Ser Ser Leu His Met Ser 
        515                 520                 525             


Asp Arg Gln Arg Val Ala Pro Lys Pro Pro Gln Met Ser Arg Ala Ala 
    530                 535                 540                 


Asp Glu Ala Leu Asn Ala Met Thr Ser Asn Gly Ser His Arg Leu Ile 
545                 550                 555                 560 


Glu Gly Val His Pro Gly Ser Leu Val Glu Lys Leu Pro Asp Ser Pro 
                565                 570                 575     


Ala Leu Ala Lys Lys Ala Leu Leu Ala Leu Asn His Gly Leu Asp Lys 
            580                 585                 590         


Ala His Ser Leu Met Glu Leu Ser Pro Ser Ala Pro Pro Gly Gly Ser 
        595                 600                 605             


Pro His Leu Asp Ser Ser Arg Ser His Ser Pro Ser Ser Pro Asp Pro 
    610                 615                 620                 


Asp Thr Pro Ser Pro Val Gly Asp Ser Arg Ala Leu Gln Ala Ser Arg 
625                 630                 635                 640 


Asn Thr Arg Ile Pro His Leu Ala Gly Lys Lys Ala Val Ala Glu Glu 
                645                 650                 655     


Asp Asn Gly Ser Ile Gly Glu Glu Thr Asp Ser Ser Pro Gly Arg Lys 
            660                 665                 670         


Lys Phe Pro Leu Lys Ile Phe Lys Lys Pro Leu Lys Lys 
        675                 680                 685 


<210>  2
<211>  4062
<212>  DNA
<213>  Homo sapiens

<400>  2
ctggacctgg gcaccgccag ccgcctgggc acgggactgg gcgggggcgc tgacctcggc       60

ctaggaggcc caggatcccg gagacgcccg cgccctcagg accctgcggg tcgcacgccc      120

tccccagctt ctgctgctcg ccgctcttcg gcagggcgag gtcaggtgcc cccttctcgc      180

ctctcttctc ttctcttctc ttcctcctcc acttctgtgc ccgcggagac tccggccgcc      240

cccttccgca ggggtgtagt aatctgcgga gctgacagca gccccgcagc caccctgccc      300

gaagtctccg gaagcggcac gagctcaggc cgccgcagcc ccggcggacc cactgttgga      360

cctgaggagc cagccctcct cccgcaccca aacttggagc acttgacctt tggctgttgg      420

agggggcagg ctcgcgggtg gctggacagc tgcggagccg cgagggcatc ttgcctggag      480

accgtcggct gcactcccgg gctcctggct ttgcctctgg gatcccgagg tgtccacatc      540

agacgcatgt tgactgagac ctagagtcat ggatgtatgc gtccgtcttg ccctgtggct      600

cctctgggga ctcctcctgc accagggcca gagcctcagc catagtcaca gtgagaaggc      660

gacaggaacc agctcggggg ccaactctga ggagtccact gcagcagagt tttgccgaat      720

tgacaagccc ctgtgtcaca gtgaggatga gaaactcagc ttcgaggcag tccgtaacat      780

ccacaaactg atggacgatg atgccaatgg tgatgtggat gtggaagaaa gtgatgagtt      840

cctgagggaa gacctcaatt accatgaccc aacagtgaaa cacagcacct tccatggtga      900

ggataagctc atcagcgtgg aggacctgtg gaaggcatgg aagtcatcag aagtatacaa      960

ttggaccgtg gatgaggtgg tacagtggct gatcacatat gtggagctgc ctcagtatga     1020

ggagaccttc cggaagctgc agctcagtgg ccatgccatg ccaaggctgg ctgtcaccaa     1080

caccaccatg acagggactg tgctgaagat gacagaccgg agtcatcggc agaagctgca     1140

gctgaaggct ctggatacag tgctctttgg gcctcctctc ttgactcgcc ataatcacct     1200

caaggacttc atgctggtgg tgtctatcgt tattggtgtg ggcggctgct ggtttgccta     1260

tatccagaac cgttactcca aggagcacat gaagaagatg atgaaggact tggaggggtt     1320

acaccgagct gagcagagtc tgcatgacct tcaggaaagg ctgcacaagg cccaggagga     1380

gcaccgcaca gtggaggtgg agaaggtcca tctggaaaag aagctgcgcg atgagatcaa     1440

ccttgctaag caggaagccc agcggctgaa ggagctgcgg gagggtactg agaatgagcg     1500

gagccgccaa aaatatgctg aggaggagtt ggagcaggtt cgggaggcct tgaggaaagc     1560

agagaaggag ctagaatctc acagctcatg gtatgctcca gaggcccttc agaagtggct     1620

gcagctgaca catgaggtgg aggtgcaata ttacaacatc aagaagcaaa atgctgagaa     1680

gcagctgctg gtggccaagg agggggctga gaagataaaa aagaagagaa acacactctt     1740

tggcaccttc cacgtggccc acagctcttc cctggatgat gtagatcata aaattctaac     1800

agctaagcaa gcactgagcg aggtgacagc agcattgcgg gagcgcctgc accgctggca     1860

acagatcgag atcctctgtg gcttccagat tgtcaacaac cctggcatcc actcactggt     1920

ggctgccctc aacatagacc ccagctggat gggcagtaca cgccccaacc ctgctcactt     1980

catcatgact gacgacgtgg atgacatgga tgaggagatt gtgtctccct tgtccatgca     2040

gtcccctagc ctgcagagca gtgttcggca gcgcctgacg gagccacagc atggcctggg     2100

atctcagagg gatttgaccc attccgattc ggagtcctcc ctccacatga gtgaccgcca     2160

gcgtgtggcc cccaaacctc ctcagatgag ccgtgctgca gacgaggctc tcaatgccat     2220

gacttccaat ggcagccacc ggctgatcga gggggtccac ccagggtctc tggtggagaa     2280

actgcctgac agccctgccc tggccaagaa ggcattactg gcgctgaacc atgggctgga     2340

caaggcccac agcctgatgg agctgagccc ctcagcccca cctggtggct ctccacattt     2400

ggattcttcc cgttctcaca gccccagctc cccagaccca gacacaccat ctccagttgg     2460

ggacagccga gccctgcaag ccagccgaaa cacacgcatt ccccacctgg ctggcaagaa     2520

ggctgtggct gaggaggata atggctctat tggcgaggaa acagactcca gcccaggccg     2580

gaagaagttt cccctcaaaa tctttaagaa gcctcttaag aagtaggcag gatggggtgg     2640

cagtaaaggg acagcttgtc cttccctggg tgttctgtct ctccttccct cccttccttc     2700

aagataactg gccccaagag tggggcatgg gaagggctgg tccaggggtc tgggcactgt     2760

acatacctgc cccctcatcc ttgggtcctt cattattatt tattaactga ccaccatggc     2820

ctgcctgccc tgcctccgtc ccaaccatgg gctgctgctg tcactccctc tccacttcag     2880

tgcatgtctt agttgctgtt ccctcagctc ccagctccac ctctggggtt cagcttctgt     2940

ctctgctgtc ccagttttga ggtttggttt cttgtttctg tctcttgctt tcgggctcct     3000

ccctcccacc actccccaac ttcccctagc agttgcaggg aagataggac gagtagcttc     3060

tgacatgtgt gcctcagatc tgttccaccc cactcacagt ggttctgttt gctccagact     3120

ggggctaggg cctaatcttt gaagtttgtt ctttggtatt gatgtgggtc agaaggagcc     3180

tcatcctaat ctcactcagg cctccaggga tccatggggg agtgaaacca attctcagag     3240

aacaacccac cagagacttt taaagagagg ccaggcttgg gaatgggttg ggagaggcat     3300

ctgttcattg gagcatgagt ggatgccaga actgtaggtt ataaggcagt cactttttct     3360

ctctactccc acccacacct gcctccctct tacccctgct cccccacact gcaggaggat     3420

ttgtctctaa gaggtgctgc cccaaagctc cccaagcatc aatactccta gggctcagga     3480

caagtggctc ccctggccag gagagccaca gccatgatac agggctctta tggagccctg     3540

gagttgttgg gcaaggatgc tgtcattttt tgaaccaaaa gacaaacagg ttaaaaggaa     3600

aaaaagtaat ctgaatttcc caagtgccta cgctgcatat tccccttgtt agatcccatt     3660

ttcatgttac tttgtagcct tggccagagg ctcaaaaagg acacaaccag tttggggaag     3720

gggtggctaa ggaagatggt ataggtgaag gcggctgtgt gaccactttc ccccaccctt     3780

cccaccctct agacaactct ctcccttacc tgtttttgct atggctgtaa aggtattttt     3840

cctctgcccc actccctgcc atacctttat cctgggatcc tattttgggc ctggggtggg     3900

tatacctggg gctggtctta ggagggtgct aggctgcaga ctgccttgta ctccctggac     3960

accctcaaat ggggttttct gtgttatttc ataaaattct ttgaagtcca ataaagcatg     4020

taggagattt taaccactaa aaaaaaaaaa aaaaaaaaaa aa                        4062


<210>  3
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  3

Leu Ser His Ser His Ser Glu Lys Ala Thr Gly Thr Ser Ser Gly Ala 
1               5                   10                  15      


Asn Ser Glu Glu Ser Thr Ala Ala Glu Phe Cys Arg Ile Asp Lys Pro 
            20                  25                  30          


Leu Cys His Ser Glu Asp Glu Lys Leu Ser Phe Glu Ala Val Arg Asn 
        35                  40                  45              


Ile His Lys Leu Met Asp Asp Asp Ala Asn Gly Asp Val Asp Val Glu 
    50                  55                  60                  


Glu Ser Asp Glu Phe Leu Arg Glu Asp Leu Asn Tyr His Asp Pro Thr 
65                  70                  75                  80  


Val Lys His Ser Thr Phe His Gly Glu Asp Lys Leu Ile Ser Val Glu 
                85                  90                  95      


Asp Leu Trp Lys Ala Trp Lys Ser Ser Glu Val Tyr Asn Trp Thr Val 
            100                 105                 110         


Asp Glu Val Val Gln Trp Leu Ile Thr Tyr Val Glu Leu Pro Gln Tyr 
        115                 120                 125             


Glu Glu Thr Phe Arg Lys Leu Gln Leu Ser Gly His Ala Met Pro Arg 
    130                 135                 140                 


Leu Ala Val Thr Asn Thr Thr Met Thr Gly Thr Val Leu Lys Met Thr 
145                 150                 155                 160 


Asp Arg Ser His Arg Gln Lys Leu Gln Leu Lys Ala Leu Asp Thr Val 
                165                 170                 175     


Leu Phe Gly Pro Pro Leu Leu Thr Arg His Asn His Leu Lys Asp 
            180                 185                 190     


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  4
tctagaactg aggcgagtgg a                                                 21


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  5
gcgctagtct ttgccaggat                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer

<400>  6
agcacttgac ctttggctgt                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer

<400>  7
atttcaactt gcccacttcg                                                   20


