                         SEQUENCE LISTING

<110>  Ruprecht-Karls-Universitt Heidelberg
 
<120>  BIOMARKER PANEL FOR THE DETECTION OF CANCER

<130>  789-10 PCT

<150>  EP 15156389.7
<151>  24.02.2015

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  1
aauggcgcca cuaggguugu g                                                 21


<210>  2
<211>  25
<212>  DNA
<213>  Homo sapiens

<400>  2
caacccuagg agagggugcc auuca                                             25


<210>  3
<211>  24
<212>  DNA
<213>  Homo sapiens

<400>  3
gauugcucug cgugcggaau cgac                                              24


<210>  4
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4
aacauagagg aaauuccacg u                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5
gguggauauu ccuucuaugu u                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6
aucauagagg aaaauccacg u                                                 21


<210>  7
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  7
guagauucuc cuucuaugag ua                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  8
ucggauccgu cugagcuugg cu                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  9
cugaagcuca gagggcucug au                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  10
gaauguugcu cggugaaccc cu                                                22


<210>  11
<211>  23
<212>  DNA
<213>  Homo sapiens

<400>  11
agguuacccg agcaacuuug cau                                               23


<210>  12
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  12
ucagugcauc acagaacuuu gu                                                22


<210>  13
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  13
aaguucuguu auacacucag gc                                                22


<210>  14
<211>  2005
<212>  DNA
<213>  Homo sapiens

<400>  14
tttcctctca gggggcagca ggaagtgagg agaaagggct gggatgggag gcgggagcgg       60

atgggaggga atggggttta tcaagtcctc ggcgagctgc ccaacgggca gcagctggcg      120

caagtagcct agctggagag gctcacccca ggaaggaggg aggccaccga cctactgggc      180

cgacggactc ccacacagtt cctgagctgg tgccaggcag gtgacacctc ctgcagcccc      240

cagcatgcgg gcaggcccag gccccaccgt tacattggcc ctggtgctgg cggtgtcatg      300

ggccatggag ctcaagccca cagcaccacc catcttcact ggccggccct ttgtggtagc      360

gtgggacgtg cccacacagg actgtggccc acgcctcaag gtgccactgg acctgaatgc      420

ctttgatgtg caggcctcac ctaatgaggg ttttgtgaac cagaatatta ccatcttcta      480

ccgcgaccgt ctaggcctgt atccacgctt cgattctgcc ggaaggtctg tgcatggtgg      540

tgtgccacag aatgtcagcc tttgggcaca ccggaagatg ctgcagaaac gtgtggagca      600

ctacattcgg acacaggagt ctgcggggct ggcggtcatc gactgggagg actggcgacc      660

tgtgtgggtg cgcaactggc aggacaaaga tgtgtatcgc cggttatcac gccagctagt      720

ggccagtcgt caccctgact ggcctccaga ccgcatagtc aaacaggcac aatatgagtt      780

tgagttcgca gcacagcagt tcatgctgga gacactgcgt tatgtcaagg cagtgcggcc      840

ccggcacctc tggggcttct acctctttcc tgactgctac aatcatgatt atgtgcagaa      900

ctgggagagc tacacaggcc gctgccctga tgttgaggtg gcccgcaatg accagctggc      960

ctggctgtgg gctgagagca cggccctctt cccgtctgtc tacctggacg agacacttgc     1020

ttcctcccgc catggccgca actttgtgag cttccgtgtt caggaggccc ttcgtgtggc     1080

tcgcacccac catgccaacc atgcactccc agtctacgtc ttcacacgac ccacctacag     1140

ccgcaggctc acggggctta gtgagatgga cctcatctct accattggcg agagtgcggc     1200

cctgggcgca gctggtgtca tcctctgggg tgacgcgggg tacaccacaa gcacggagac     1260

ctgccagtac ctcaaagatt acctgacacg gctgctggtc ccctacgtgg tcaatgtgtc     1320

ctgggccacc caatattgca gccgggccca gtgccatggc catgggcgct gtgtgcgccg     1380

caaccccagt gccagtacct tcctgcatct cagcaccaac agtttccgcc tagtgcctgg     1440

ccatgcacct ggtgaacccc agctgcgacc tgtgggggag ctcagttggg ccgacattga     1500

ccacctgcag acacacttcc gctgccagtg ctacttgggc tggagtggtg agcaatgcca     1560

gtgggaccat aggcaggcag ctggaggtgc cagcgaggcc tgggctgggt cccacctcac     1620

cagtctgctg gctctggcag ccctggcctt tacctggacc ttgtaggggt ctcctgccta     1680

gctgcctagc aagctggcct ctaccacaag ggctctctta ggcatgtagg accctgcagg     1740

gggtggacaa actggagtct ggagtgggca gagcccccag gaagcccagg agggcatcca     1800

taccagctcg cacccccctg ttctaagggg gaggggaagt ccctgggagg ccccttctct     1860

ccctgccaga ggggaaggag ggtacagctg ggctggggag gacctgaccc tactcccttg     1920

ccctagatag tttattatta ttattatttt ggggtctctt ttgtaaatta aacataaaac     1980

aattgcttct ctgcttggat tttgt                                           2005


<210>  15
<211>  2413
<212>  DNA
<213>  Homo sapiens

<400>  15
tttcctctca gggggcagca ggaagtgagg agaaagggct gggatgggag gcgggagcgg       60

atgggaggga atggggttta tcaagtcctc ggcgagctgc ccaacgggca gcagctggcg      120

caagtagcct agctggagag gctcacccca ggaaggaggg aggccaccga cctactgggc      180

cgacggactc ccacacaggg ctggcggcgc cgcggagctg ggaggactga accaccggcc      240

tcgggctgca ggggaaacat ttcaggctga ctggcgctcg tggctgagac tcccatagaa      300

agcccggctc agaggggcat tagggtccta aatgggcggc cacgtccctc tgcagaggac      360

ctggggctct tcgagcccga aacgaggcac cggcaccgag aaaggtggac cacaccttcc      420

cgccccgtcc gcaagtccaa tcccgggccc acctccgcac tggagtctta aagggccagc      480

gtgcctgggg gcggagccag cagaggcgct gagccgggcc gcgcctgggc gaacggccgg      540

agcgggctgg gctgggcccg ggatggcggt ggccctggcg ccggtcccgg tggcgccccg      600

cgcgagttcc tgagctggtg ccaggcaggt gacacctcct gcagccccca gcatgcgggc      660

aggcccaggc cccaccgtta cattggccct ggtgctggcg gtgtcatggg ccatggagct      720

caagcccaca gcaccaccca tcttcactgg ccggcccttt gtggtagcgt gggacgtgcc      780

cacacaggac tgtggcccac gcctcaaggt gccactggac ctgaatgcct ttgatgtgca      840

ggcctcacct aatgagggtt ttgtgaacca gaatattacc atcttctacc gcgaccgtct      900

aggcctgtat ccacgcttcg attctgccgg aaggtctgtg catggtggtg tgccacagaa      960

tgtcagcctt tgggcacacc ggaagatgct gcagaaacgt gtggagcact acattcggac     1020

acaggagtct gcggggctgg cggtcatcga ctgggaggac tggcgacctg tgtgggtgcg     1080

caactggcag gacaaagatg tgtatcgccg gttatcacgc cagctagtgg ccagtcgtca     1140

ccctgactgg cctccagacc gcatagtcaa acaggcacaa tatgagtttg agttcgcagc     1200

acagcagttc atgctggaga cactgcgtta tgtcaaggca gtgcggcccc ggcacctctg     1260

gggcttctac ctctttcctg actgctacaa tcatgattat gtgcagaact gggagagcta     1320

cacaggccgc tgccctgatg ttgaggtggc ccgcaatgac cagctggcct ggctgtgggc     1380

tgagagcacg gccctcttcc cgtctgtcta cctggacgag acacttgctt cctcccgcca     1440

tggccgcaac tttgtgagct tccgtgttca ggaggccctt cgtgtggctc gcacccacca     1500

tgccaaccat gcactcccag tctacgtctt cacacgaccc acctacagcc gcaggctcac     1560

ggggcttagt gagatggacc tcatctctac cattggcgag agtgcggccc tgggcgcagc     1620

tggtgtcatc ctctggggtg acgcggggta caccacaagc acggagacct gccagtacct     1680

caaagattac ctgacacggc tgctggtccc ctacgtggtc aatgtgtcct gggccaccca     1740

atattgcagc cgggcccagt gccatggcca tgggcgctgt gtgcgccgca accccagtgc     1800

cagtaccttc ctgcatctca gcaccaacag tttccgccta gtgcctggcc atgcacctgg     1860

tgaaccccag ctgcgacctg tgggggagct cagttgggcc gacattgacc acctgcagac     1920

acacttccgc tgccagtgct acttgggctg gagtggtgag caatgccagt gggaccatag     1980

gcaggcagct ggaggtgcca gcgaggcctg ggctgggtcc cacctcacca gtctgctggc     2040

tctggcagcc ctggccttta cctggacctt gtaggggtct cctgcctagc tgcctagcaa     2100

gctggcctct accacaaggg ctctcttagg catgtaggac cctgcagggg gtggacaaac     2160

tggagtctgg agtgggcaga gcccccagga agcccaggag ggcatccata ccagctcgca     2220

cccccctgtt ctaaggggga ggggaagtcc ctgggaggcc ccttctctcc ctgccagagg     2280

ggaaggaggg tacagctggg ctggggagga cctgacccta ctcccttgcc ctagatagtt     2340

tattattatt attattttgg ggtctctttt gtaaattaaa cataaaacaa ttgcttctct     2400

gcttggattt tgt                                                        2413


<210>  16
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                85                  90                  95      


His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
            100                 105                 110         


Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly 
        115                 120                 125             


Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn 
    130                 135                 140                 


Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala 
145                 150                 155                 160 


Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln 
                165                 170                 175     


Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg 
            180                 185                 190         


Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe 
        195                 200                 205             


Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr 
    210                 215                 220                 


Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp 
225                 230                 235                 240 


Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu 
                245                 250                 255     


Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val 
            260                 265                 270         


Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu 
        275                 280                 285             


Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly 
    290                 295                 300                 


Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
305                 310                 315                 320 


Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser 
                325                 330                 335     


Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val 
            340                 345                 350         


Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala 
        355                 360                 365             


Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
    370                 375                 380                 


Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His 
385                 390                 395                 400 


Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala 
                405                 410                 415     


Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly 
            420                 425                 430         


Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly 
        435                 440                 445             


Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu 
    450                 455                 460                 


Ala Ala Leu Ala Phe Thr Trp Thr Leu 
465                 470             


<210>  17
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Arg Ala Gly Pro Gly Pro Thr Val Thr Leu Ala Leu Val Leu Ala 
1               5                   10                  15      


Val Ser Trp Ala Met Glu Leu Lys Pro Thr Ala Pro Pro Ile Phe Thr 
            20                  25                  30          


Gly Arg Pro Phe Val Val Ala Trp Asp Val Pro Thr Gln Asp Cys Gly 
        35                  40                  45              


Pro Arg Leu Lys Val Pro Leu Asp Leu Asn Ala Phe Asp Val Gln Ala 
    50                  55                  60                  


Ser Pro Asn Glu Gly Phe Val Asn Gln Asn Ile Thr Ile Phe Tyr Arg 
65                  70                  75                  80  


Asp Arg Leu Gly Leu Tyr Pro Arg Phe Asp Ser Ala Gly Arg Ser Val 
                85                  90                  95      


His Gly Gly Val Pro Gln Asn Val Ser Leu Trp Ala His Arg Lys Met 
            100                 105                 110         


Leu Gln Lys Arg Val Glu His Tyr Ile Arg Thr Gln Glu Ser Ala Gly 
        115                 120                 125             


Leu Ala Val Ile Asp Trp Glu Asp Trp Arg Pro Val Trp Val Arg Asn 
    130                 135                 140                 


Trp Gln Asp Lys Asp Val Tyr Arg Arg Leu Ser Arg Gln Leu Val Ala 
145                 150                 155                 160 


Ser Arg His Pro Asp Trp Pro Pro Asp Arg Ile Val Lys Gln Ala Gln 
                165                 170                 175     


Tyr Glu Phe Glu Phe Ala Ala Gln Gln Phe Met Leu Glu Thr Leu Arg 
            180                 185                 190         


Tyr Val Lys Ala Val Arg Pro Arg His Leu Trp Gly Phe Tyr Leu Phe 
        195                 200                 205             


Pro Asp Cys Tyr Asn His Asp Tyr Val Gln Asn Trp Glu Ser Tyr Thr 
    210                 215                 220                 


Gly Arg Cys Pro Asp Val Glu Val Ala Arg Asn Asp Gln Leu Ala Trp 
225                 230                 235                 240 


Leu Trp Ala Glu Ser Thr Ala Leu Phe Pro Ser Val Tyr Leu Asp Glu 
                245                 250                 255     


Thr Leu Ala Ser Ser Arg His Gly Arg Asn Phe Val Ser Phe Arg Val 
            260                 265                 270         


Gln Glu Ala Leu Arg Val Ala Arg Thr His His Ala Asn His Ala Leu 
        275                 280                 285             


Pro Val Tyr Val Phe Thr Arg Pro Thr Tyr Ser Arg Arg Leu Thr Gly 
    290                 295                 300                 


Leu Ser Glu Met Asp Leu Ile Ser Thr Ile Gly Glu Ser Ala Ala Leu 
305                 310                 315                 320 


Gly Ala Ala Gly Val Ile Leu Trp Gly Asp Ala Gly Tyr Thr Thr Ser 
                325                 330                 335     


Thr Glu Thr Cys Gln Tyr Leu Lys Asp Tyr Leu Thr Arg Leu Leu Val 
            340                 345                 350         


Pro Tyr Val Val Asn Val Ser Trp Ala Thr Gln Tyr Cys Ser Arg Ala 
        355                 360                 365             


Gln Cys His Gly His Gly Arg Cys Val Arg Arg Asn Pro Ser Ala Ser 
    370                 375                 380                 


Thr Phe Leu His Leu Ser Thr Asn Ser Phe Arg Leu Val Pro Gly His 
385                 390                 395                 400 


Ala Pro Gly Glu Pro Gln Leu Arg Pro Val Gly Glu Leu Ser Trp Ala 
                405                 410                 415     


Asp Ile Asp His Leu Gln Thr His Phe Arg Cys Gln Cys Tyr Leu Gly 
            420                 425                 430         


Trp Ser Gly Glu Gln Cys Gln Trp Asp His Arg Gln Ala Ala Gly Gly 
        435                 440                 445             


Ala Ser Glu Ala Trp Ala Gly Ser His Leu Thr Ser Leu Leu Ala Leu 
    450                 455                 460                 


Ala Ala Leu Ala Phe Thr Trp Thr Leu 
465                 470             


<210>  18
<211>  3868
<212>  DNA
<213>  Homo sapiens

<400>  18
gtgggggctc gaggcgcctc cgcggccgtg gacgagcgtc cgtgcggcct ggtccgggcc       60

atgtccgcgt gaggaccccg ccgctgtcgc cgctcccgtt ccggccctgg cccctctgcc      120

cggcagcgcc gcgcaccatg ggctccattc tcagccgccg catcgcgggg gtggaggaca      180

tcgacatcca ggcgaactcg gcctatcgct accctccgaa gtccggaaac tactttgctt      240

cgcacttttt catgggagga gagaaattcg acacccccca ccctgaaggt tacctctttg      300

gagagaacat ggatctgaac ttcctgggca gccgcccggt ccagtttccc tacgtcactc      360

ctgcccccca cgagcccgtg aagacgctgc ggagcctggt gaacatccgc aaagactccc      420

tgcggctggt gaggtacaaa gacgatgccg acagccccac cgaggacggc gacaagcccc      480

gggtgctcta cagcctggag ttcaccttcg acgccgatgc ccgcgtggcc atcaccatct      540

actgccaggc atcggaggag ttcctgaacg gcagggcagt atacagcccc aagagcccct      600

cgctacagtc cgagaccgtc cactacaaga gaggggtgag ccagcagttc tccctgccct      660

ccttcaagat tgacttctcg gaatggaagg atgacgagct gaactttgac ctggaccggg      720

gcgtgtttcc agtagtcatc caggctgtgg tggacgaagg agatgtggtg gaagtgactg      780

gccacgccca cgtgctcttg gctgcctttg aaaagcacat ggacggcagc ttctctgtga      840

agcctttaaa gcagaagcaa attgtggacc gggtcagcta cctcctgcag gagatctatg      900

gcattgagaa caagaacaac caggagacca agccctcgga cgacgagaac agcgacaaca      960

gcaacgagtg tgtggtgtgc ctgtccgacc tgcgggacac gctgatcctg ccctgccgcc     1020

acctgtgcct ctgtacctcc tgcgccgaca cgctgcgcta ccaggccaac aactgcccca     1080

tctgccggct gcctttccgg gccctcctgc agatccgggc ggtgcggaag aagccaggag     1140

ccctgtcccc cgtgtccttc agccccgtcc tggcccagag cctggagcat gatgagcact     1200

ctaactctga cagcgtccca cctggctacg agcccatctc gctgctcgag gcgctcaacg     1260

gcctccgggc tgtctccccg gccatcccct cggcccctct ttatgaagaa atcacctatt     1320

caggcatctc ggacggcctg tcccaggcca gctgtcccct cgcggctatc gaccacatcc     1380

tggacagcag ccgccagaag ggcaggccgc agagcaaggc ccccgacagc accctacggt     1440

ccccgtcttc ccccatccac gaagaggatg aggagaagct ctccgaggac gtggacgccc     1500

ctcccccact gggtggcgca gagctggccc tgcgggaaag cagctcccct gagagtttca     1560

taacagaaga ggttgatgag tcgtcgtcac cacagcaagg gacccgagca gcttccattg     1620

agaatgtcct gcaggacagc agccccgagc actgtggccg aggcccacct gctgacatct     1680

acctgccagg acggcccacc tccatggaga cggcccacgg cctcgccacc accagcccca     1740

cctggcctcc acttggtggc cccagccccg atcccagcgc cgccgagctg accccactct     1800

gagagcctgg ccgagctggc agcatggagc cctcggctcc ccagactttg ccgaggggct     1860

gctccggacc ccgttgtgag ccggcctcct gtctgcatgc cccctgtggc caccaggctc     1920

cgaggggccg tggtgactct tgatcaaaga gcacagtgaa ctgtcccttc tgagtctccc     1980

ttttctacag ttgatatatt tgtaactggt acaagatgaa ggacagcagc tttccatccc     2040

tagttcagag cccccgttcc ccagggtcct gtgggctgag cggctggggc tggggctgcc     2100

cacgtgtggc ctccgctggc tctgcctgct cctgcaacag tgcggtccct gcccggagaa     2160

ctcaggaggc ctgcagaaga gaactgattg gtggtcgaag caccatcttc acagatgttc     2220

aggggcagtg gggggctcca ggcacggtca atgaaggaaa cagtgcctgt ccacccaccc     2280

tgcgtgtcac tgtggcggcc tggctgtcgc tgctttttgt cctctgccgt gtttgcgcgg     2340

cctcagtgcc ctccctggtg cgtctgcgct ggggccctca gtgctcgggg ccttggggtg     2400

catgggtgcc gccctgggca gctagagtgt ctcagcccgg tgctgggcct ggccgagggg     2460

cggaggcaca gctgcttcca gcagccagca ttcagtggcc ttgtcaccaa gctccacacc     2520

tcctcctggt gctggctttg gtgacatcac aaggcccctc caggtgcagg ggcttctgtt     2580

tggcaggccc ctgccaggga ggacctggtg gcctcctcat tctcttttgc cattggaatg     2640

tccccttgca gttctcttct cttttttttt ttttttgaga tggagtttca ctcttgctgc     2700

ccaggctgga gtgcagtggc tcaatctcgg gtcactgcaa cctccgcctc ccgggttcaa     2760

gtgatcgtcc tgccttaggc tcctgagtag ctggggatta caggtgccta ccagcatgct     2820

cggctaattt ttttgtattt ttagtagaga agggatttca ccatgttggc cgggctggtc     2880

tcaaactcct aaggtcatcc acctgcctcg gcctcccaga gtgctgagat tacaggcgtg     2940

agcctccgcg cccggccccc ttgcagttct ctctgatttg gtttgttctg tctcaggctt     3000

ctgtggcagg actggcccag ggaggaggaa gccagcagca cacctgggga atggggtccc     3060

ggccgggagg cttggcctct gggcgacctc gtcctgtttt ttttgtttgt ttgtttgttt     3120

ttttaaaggt aaacctcctg ggccgcagat ggcaaaggga gtgcctgggc ctggtgaccc     3180

agggctggat ccacccctgc ggagccctgg gccaggcagg tgtctgctgc tcacctggct     3240

ctggagggct gccctgcagc tgggcctggg gacaggtcgg ctgtggggca gctcagtacc     3300

ctccctgagg ctcacggtgg ctccgagcat gaggtccgcc tcctgggcga gacccagcag     3360

tggacagcat ggtcctcaca cccagctccc tgcacaccca ggccagccac ccctcccgct     3420

cgtgcacagg cacgcagatg cgctcacacg tacacacaca caaatgcacg cccacttgca     3480

catgctcacg cacatgttca cacatgcaca ctcacgctca cacatgctgt cacgcataca     3540

cacacgcaca tactcctgca catgttccca tgcatgtgtg tgcactcgga ccgagcatct     3600

cccacgcacc tctaccccac cccaagcacc tctctccccc catgcacctc tccccaacaa     3660

cacacacagc cccctgcacc gcccgccccc cgcccccacc aaggccccag cctctggcca     3720

tcagtcctgg tgccagagct ttgcgtgaag ttcgggccgc agagtggccc gctgggactc     3780

ccatgtgctg ccgtctgatg tgctcagatg ggctcatcgt tggttcgttt ttactgtata     3840

tttatagtaa taaaatcatg cagcaata                                        3868


<210>  19
<211>  6471
<212>  DNA
<213>  Homo sapiens

<400>  19
gtgggggctc gaggcgcctc cgcggccgtg gacgagcgtc cgtgcggcct ggtccgggcc       60

atgtccgcgt gaggaccccg ccgctgtcgc cgctcccgtt ccggccctgg cccctctgcc      120

cggcagcgcc gcgcaccatg ggctccattc tcagccgccg catcgcgggg gtggaggaca      180

tcgacatcca ggcgaactcg gcctatcgct accctccgaa gtccggaaac tactttgctt      240

cgcacttttt catgggagga gagaaattcg acacccccca ccctgaaggt tacctctttg      300

gagagaacat ggatctgaac ttcctgggca gccgcccggt ccagtttccc tacgtcactc      360

ctgcccccca cgagcccgtg aagacgctgc ggagcctggt gaacatccgc aaagactccc      420

tgcggctggt gaggtacaaa gacgatgccg acagccccac cgaggacggc gacaagcccc      480

gggtgctcta cagcctggag ttcaccttcg acgccgatgc ccgcgtggcc atcaccatct      540

actgccaggc atcggaggag ttcctgaacg gcagggcagt atacagcccc aagagcccct      600

cgctacagtc cgagaccgtc cactacaaga gaggggtgag ccagcagttc tccctgccct      660

ccttcaagat tgacttctcg gaatggaagg atgacgagct gaactttgac ctggaccggg      720

gcgtgtttcc agtagtcatc caggctgtgg tggacgaagg agatgtggtg gaagtgactg      780

gccacgccca cgtgctcttg gctgcctttg aaaagcacat ggacggcagc ttctctgtga      840

agcctttaaa gcagaagcaa attgtggacc gggtcagcta cctcctgcag gagatctatg      900

gcattgagaa caagaacaac caggagacca agccctcgga cgacgagaac agcgacaaca      960

gcaacgagtg tgtggtgtgc ctgtccgacc tgcgggacac gctgatcctg ccctgccgcc     1020

acctgtgcct ctgtacctcc tgcgccgaca cgctgcgcta ccaggccaac aactgcccca     1080

tctgccggct gcctttccgg gccctcctgc agatccgggc ggtgcggaag aagccaggag     1140

ccctgtcccc cgtgtccttc agccccgtcc tggcccagag cctggagcat gatgagcact     1200

cttgtccctt taaaaaatca aagccgcacc ccgcctccct ggccagcaag aaacctaaaa     1260

gggaaacaaa ctctgacagc gtcccacctg gctacgagcc catctcgctg ctcgaggcgc     1320

tcaacggcct ccgggctgtc tccccggcca tcccctcggc ccctctttat gaagaaatca     1380

cctattcagg catctcggac ggcctgtccc aggccagctg tcccctcgcg gctatcgacc     1440

acatcctgga cagcagccgc cagaagggca ggccgcagag caaggccccc gacagcaccc     1500

tacggtcccc gtcttccccc atccacgaag aggatgagga gaagctctcc gaggacgtgg     1560

acgcccctcc cccactgggt ggcgcagagc tggccctgcg ggaaagcagc tcccctgaga     1620

gtttcataac agaagaggtt gatgagtcgt cgtcaccaca gcaagggacc cgagcagctt     1680

ccattgagaa tgtcctgcag gacagcagcc ccgagcactg tggccgaggc ccacctgctg     1740

acatctacct gccagccctg gggcccgact cctgctctgt tggtatagac gagtaagccg     1800

gtacgtgacc tcccagacgc gcttcggggg ctctgacgcg cgtccttgga gagaggagcc     1860

ctcccctgct ctctggcggg ggttccttct ggtttttggg tcttcgtccg catccgcatc     1920

ttcccagggg ccctggattc cgaatccaga gctctccagt ggctgctgca ccttccccca     1980

gaaagtggcc tcctgggggg tcctgacttt cggggccaga ggtctctcca tctggactag     2040

gcggccggtc aggctcttct tccagccttg aggggccctg gaacagtccc agcccaggca     2100

gggagacaga cacagcccag gtgcgccaga gccactgtcc actgcgggag gcaggagctt     2160

gagggatgag ggcagcaccg tggagggaac cccagggaga catggggtga gcgtcccaag     2220

gggagaggcc tgggcctggc cttgttccgg atggtcccac catgagttcg catcggtcct     2280

gcagcagaca cgttaggacg ctcagcaggt ccactcccgt gttccggtcg tggctttaac     2340

aattcatggg gaaagaatgc gccccgattg ggagagcccc tggatcacgt cttcccaagc     2400

tcagtccctg tctcttggag ggagtccgtc ctcgaggggc cctctggtgc ccaggggaga     2460

gtatcttgcg tcctgtcctg agggcgtccg ctcacacagc cacctgctcc cccgctccct     2520

ccttcccttg tcagcatggc caccgtgggc ctggcatcac catgggcctg gcacacagtc     2580

cctcgtgggc tgcctttgtg ccatgagccc actgctgccg actcacctgt ccctcccagt     2640

actggaacct tctggaacac cagcactaaa agataggagg ccctgtgagg ttggcatccc     2700

ccatcccccc caagaggcgc cctctaccag ggtggcccag gtgagtgttt tacagaaggc     2760

ggctctgtcc aggcagtggt tcgcacctat aagcccggta ctttgggaga ccgaggggat     2820

agatcacttg agcccaggaa ttcaagatca gtgtagaaaa catagacccc ctctctatga     2880

aaaataaaaa attggcttgg gcgtggtagc ttgtgcctgt ggtcccagct actcaggggt     2940

gctgaggtgg gaggattgcc ggagctgggg aggtcaaggc ccactccagc ctgagacgct     3000

gtctcaataa aaaaaaatac acacacaccc acccacccac tccagcctga gaccctgtct     3060

caagaaaaaa aaaatacaca cacacacaca cacacacaca cacacggggg agagagagaa     3120

ggcagctcca ggagtgccac caaaatgtag gcagacggat tggggaccct ctgccttccc     3180

agagggtctt ggcacacaag ctgcgtgcag ctctggtctg ccgaggccca tgcagcctgc     3240

tgggaggtgc ctggccgggg gtgcaggctc taagaggccc tttccccttg ggtggacttg     3300

agccgggtca gggagaactt cgcttctttt gactgcgctc tgcattccca tgaacctctg     3360

tcttcttgag cccagcgagt ccctctgttg acccctgtcc tgagccatta tacccctaga     3420

ttgaaacagt cagcaccttt cagacggccc cggcctgcgc atcggtggaa ggtgccgtgc     3480

gaatgtcacg attcaggtca agcttccgga gctggggagt gcaggtgtga tctagaacag     3540

ggctcacagc ctcggaaacc tgctctcgcc gcggcccccg aagaaaatag acgcccttca     3600

ccggagagtg gggcctgggc cgtgtctgct gggagccatg tgtcagggct ggtggctggg     3660

tgtcaggcag ccctgaggcc atgctggccc cgtcccaggc tctgcaccag caccattgcc     3720

caagccccag ggacgccaga cccatctggg gacagcgccc ggcggcgtcg tgcaggccac     3780

agtctgggca ttggggctct gtgggaggct cctctctttg ccttgcagta gccatccggg     3840

ggctactctg agcacgggct tgttctcacc cagggccgct ccccacccct gcaccctggg     3900

ttgaccgagt tccaccctaa cccagccgta agaaccttgg caggacagtg gctggccaca     3960

tcccaggaaa ccggaaccag ggcaagggca ggaggcccag agggcatcca ccgcggtgcc     4020

gtgtcgcgct ctgactcggg gctgcagatc tgctgtgggt gtccggggat ctgggatcgt     4080

ctgtcccaag agggacacag cgtatttggc acagttaggg agtccccggg cccttggtgt     4140

gctcacatct gagtgaatgc tgttgtggcc acaggcggcg ggagtggggg tgctggatgg     4200

cccagcccct ctggggctcc agatcggtag gagcgggtgg cgtggcacca ggcatccgag     4260

tgtgaccctc ctccctctgc tcccacctgc aggacggccc acctccatgg agacggccca     4320

cggcctcgcc accaccagcc ccacctggcc tccacttggt ggccccagcc ccgatcccag     4380

cgccgccgag ctgaccccac tctgagagcc tggccgagct ggcagcatgg agccctcggc     4440

tccccagact ttgccgaggg gctgctccgg accccgttgt gagccggcct cctgtctgca     4500

tgccccctgt ggccaccagg ctccgagggg ccgtggtgac tcttgatcaa agagcacagt     4560

gaactgtccc ttctgagtct cccttttcta cagttgatat atttgtaact ggtacaagat     4620

gaaggacagc agctttccat ccctagttca gagcccccgt tccccagggt cctgtgggct     4680

gagcggctgg ggctggggct gcccacgtgt ggcctccgct ggctctgcct gctcctgcaa     4740

cagtgcggtc cctgcccgga gaactcagga ggcctgcaga agagaactga ttggtggtcg     4800

aagcaccatc ttcacagatg ttcaggggca gtggggggct ccaggcacgg tcaatgaagg     4860

aaacagtgcc tgtccaccca ccctgcgtgt cactgtggcg gcctggctgt cgctgctttt     4920

tgtcctctgc cgtgtttgcg cggcctcagt gccctccctg gtgcgtctgc gctggggccc     4980

tcagtgctcg gggccttggg gtgcatgggt gccgccctgg gcagctagag tgtctcagcc     5040

cggtgctggg cctggccgag gggcggaggc acagctgctt ccagcagcca gcattcagtg     5100

gccttgtcac caagctccac acctcctcct ggtgctggct ttggtgacat cacaaggccc     5160

ctccaggtgc aggggcttct gtttggcagg cccctgccag ggaggacctg gtggcctcct     5220

cattctcttt tgccattgga atgtcccctt gcagttctct tctctttttt tttttttttg     5280

agatggagtt tcactcttgc tgcccaggct ggagtgcagt ggctcaatct cgggtcactg     5340

caacctccgc ctcccgggtt caagtgatcg tcctgcctta ggctcctgag tagctgggga     5400

ttacaggtgc ctaccagcat gctcggctaa tttttttgta tttttagtag agaagggatt     5460

tcaccatgtt ggccgggctg gtctcaaact cctaaggtca tccacctgcc tcggcctccc     5520

agagtgctga gattacaggc gtgagcctcc gcgcccggcc cccttgcagt tctctctgat     5580

ttggtttgtt ctgtctcagg cttctgtggc aggactggcc cagggaggag gaagccagca     5640

gcacacctgg ggaatggggt cccggccggg aggcttggcc tctgggcgac ctcgtcctgt     5700

tttttttgtt tgtttgtttg tttttttaaa ggtaaacctc ctgggccgca gatggcaaag     5760

ggagtgcctg ggcctggtga cccagggctg gatccacccc tgcggagccc tgggccaggc     5820

aggtgtctgc tgctcacctg gctctggagg gctgccctgc agctgggcct ggggacaggt     5880

cggctgtggg gcagctcagt accctccctg aggctcacgg tggctccgag catgaggtcc     5940

gcctcctggg cgagacccag cagtggacag catggtcctc acacccagct ccctgcacac     6000

ccaggccagc cacccctccc gctcgtgcac aggcacgcag atgcgctcac acgtacacac     6060

acacaaatgc acgcccactt gcacatgctc acgcacatgt tcacacatgc acactcacgc     6120

tcacacatgc tgtcacgcat acacacacgc acatactcct gcacatgttc ccatgcatgt     6180

gtgtgcactc ggaccgagca tctcccacgc acctctaccc caccccaagc acctctctcc     6240

ccccatgcac ctctccccaa caacacacac agccccctgc accgcccgcc ccccgccccc     6300

accaaggccc cagcctctgg ccatcagtcc tggtgccaga gctttgcgtg aagttcgggc     6360

cgcagagtgg cccgctggga ctcccatgtg ctgccgtctg atgtgctcag atgggctcat     6420

cgttggttcg tttttactgt atatttatag taataaaatc atgcagcaat a              6471


<210>  20
<211>  6405
<212>  DNA
<213>  Homo sapiens

<400>  20
gtgggggctc gaggcgcctc cgcggccgtg gacgagcgtc cgtgcggcct ggtccgggcc       60

atgtccgcgt gaggaccccg ccgctgtcgc cgctcccgtt ccggccctgg cccctctgcc      120

cggcagcgcc gcgcaccatg ggctccattc tcagccgccg catcgcgggg gtggaggaca      180

tcgacatcca ggcgaactcg gcctatcgct accctccgaa gtccggaaac tactttgctt      240

cgcacttttt catgggagga gagaaattcg acacccccca ccctgaaggt tacctctttg      300

gagagaacat ggatctgaac ttcctgggca gccgcccggt ccagtttccc tacgtcactc      360

ctgcccccca cgagcccgtg aagacgctgc ggagcctggt gaacatccgc aaagactccc      420

tgcggctggt gaggtacaaa gacgatgccg acagccccac cgaggacggc gacaagcccc      480

gggtgctcta cagcctggag ttcaccttcg acgccgatgc ccgcgtggcc atcaccatct      540

actgccaggc atcggaggag ttcctgaacg gcagggcagt atacagcccc aagagcccct      600

cgctacagtc cgagaccgtc cactacaaga gaggggtgag ccagcagttc tccctgccct      660

ccttcaagat tgacttctcg gaatggaagg atgacgagct gaactttgac ctggaccggg      720

gcgtgtttcc agtagtcatc caggctgtgg tggacgaagg agatgtggtg gaagtgactg      780

gccacgccca cgtgctcttg gctgcctttg aaaagcacat ggacggcagc ttctctgtga      840

agcctttaaa gcagaagcaa attgtggacc gggtcagcta cctcctgcag gagatctatg      900

gcattgagaa caagaacaac caggagacca agccctcgga cgacgagaac agcgacaaca      960

gcaacgagtg tgtggtgtgc ctgtccgacc tgcgggacac gctgatcctg ccctgccgcc     1020

acctgtgcct ctgtacctcc tgcgccgaca cgctgcgcta ccaggccaac aactgcccca     1080

tctgccggct gcctttccgg gccctcctgc agatccgggc ggtgcggaag aagccaggag     1140

ccctgtcccc cgtgtccttc agccccgtcc tggcccagag cctggagcat gatgagcact     1200

ctaactctga cagcgtccca cctggctacg agcccatctc gctgctcgag gcgctcaacg     1260

gcctccgggc tgtctccccg gccatcccct cggcccctct ttatgaagaa atcacctatt     1320

caggcatctc ggacggcctg tcccaggcca gctgtcccct cgcggctatc gaccacatcc     1380

tggacagcag ccgccagaag ggcaggccgc agagcaaggc ccccgacagc accctacggt     1440

ccccgtcttc ccccatccac gaagaggatg aggagaagct ctccgaggac gtggacgccc     1500

ctcccccact gggtggcgca gagctggccc tgcgggaaag cagctcccct gagagtttca     1560

taacagaaga ggttgatgag tcgtcgtcac cacagcaagg gacccgagca gcttccattg     1620

agaatgtcct gcaggacagc agccccgagc actgtggccg aggcccacct gctgacatct     1680

acctgccagc cctggggccc gactcctgct ctgttggtat agacgagtaa gccggtacgt     1740

gacctcccag acgcgcttcg ggggctctga cgcgcgtcct tggagagagg agccctcccc     1800

tgctctctgg cgggggttcc ttctggtttt tgggtcttcg tccgcatccg catcttccca     1860

ggggccctgg attccgaatc cagagctctc cagtggctgc tgcaccttcc cccagaaagt     1920

ggcctcctgg ggggtcctga ctttcggggc cagaggtctc tccatctgga ctaggcggcc     1980

ggtcaggctc ttcttccagc cttgaggggc cctggaacag tcccagccca ggcagggaga     2040

cagacacagc ccaggtgcgc cagagccact gtccactgcg ggaggcagga gcttgaggga     2100

tgagggcagc accgtggagg gaaccccagg gagacatggg gtgagcgtcc caaggggaga     2160

ggcctgggcc tggccttgtt ccggatggtc ccaccatgag ttcgcatcgg tcctgcagca     2220

gacacgttag gacgctcagc aggtccactc ccgtgttccg gtcgtggctt taacaattca     2280

tggggaaaga atgcgccccg attgggagag cccctggatc acgtcttccc aagctcagtc     2340

cctgtctctt ggagggagtc cgtcctcgag gggccctctg gtgcccaggg gagagtatct     2400

tgcgtcctgt cctgagggcg tccgctcaca cagccacctg ctcccccgct ccctccttcc     2460

cttgtcagca tggccaccgt gggcctggca tcaccatggg cctggcacac agtccctcgt     2520

gggctgcctt tgtgccatga gcccactgct gccgactcac ctgtccctcc cagtactgga     2580

accttctgga acaccagcac taaaagatag gaggccctgt gaggttggca tcccccatcc     2640

cccccaagag gcgccctcta ccagggtggc ccaggtgagt gttttacaga aggcggctct     2700

gtccaggcag tggttcgcac ctataagccc ggtactttgg gagaccgagg ggatagatca     2760

cttgagccca ggaattcaag atcagtgtag aaaacataga ccccctctct atgaaaaata     2820

aaaaattggc ttgggcgtgg tagcttgtgc ctgtggtccc agctactcag gggtgctgag     2880

gtgggaggat tgccggagct ggggaggtca aggcccactc cagcctgaga cgctgtctca     2940

ataaaaaaaa atacacacac acccacccac ccactccagc ctgagaccct gtctcaagaa     3000

aaaaaaaata cacacacaca cacacacaca cacacacacg ggggagagag agaaggcagc     3060

tccaggagtg ccaccaaaat gtaggcagac ggattgggga ccctctgcct tcccagaggg     3120

tcttggcaca caagctgcgt gcagctctgg tctgccgagg cccatgcagc ctgctgggag     3180

gtgcctggcc gggggtgcag gctctaagag gccctttccc cttgggtgga cttgagccgg     3240

gtcagggaga acttcgcttc ttttgactgc gctctgcatt cccatgaacc tctgtcttct     3300

tgagcccagc gagtccctct gttgacccct gtcctgagcc attatacccc tagattgaaa     3360

cagtcagcac ctttcagacg gccccggcct gcgcatcggt ggaaggtgcc gtgcgaatgt     3420

cacgattcag gtcaagcttc cggagctggg gagtgcaggt gtgatctaga acagggctca     3480

cagcctcgga aacctgctct cgccgcggcc cccgaagaaa atagacgccc ttcaccggag     3540

agtggggcct gggccgtgtc tgctgggagc catgtgtcag ggctggtggc tgggtgtcag     3600

gcagccctga ggccatgctg gccccgtccc aggctctgca ccagcaccat tgcccaagcc     3660

ccagggacgc cagacccatc tggggacagc gcccggcggc gtcgtgcagg ccacagtctg     3720

ggcattgggg ctctgtggga ggctcctctc tttgccttgc agtagccatc cgggggctac     3780

tctgagcacg ggcttgttct cacccagggc cgctccccac ccctgcaccc tgggttgacc     3840

gagttccacc ctaacccagc cgtaagaacc ttggcaggac agtggctggc cacatcccag     3900

gaaaccggaa ccagggcaag ggcaggaggc ccagagggca tccaccgcgg tgccgtgtcg     3960

cgctctgact cggggctgca gatctgctgt gggtgtccgg ggatctggga tcgtctgtcc     4020

caagagggac acagcgtatt tggcacagtt agggagtccc cgggcccttg gtgtgctcac     4080

atctgagtga atgctgttgt ggccacaggc ggcgggagtg ggggtgctgg atggcccagc     4140

ccctctgggg ctccagatcg gtaggagcgg gtggcgtggc accaggcatc cgagtgtgac     4200

cctcctccct ctgctcccac ctgcaggacg gcccacctcc atggagacgg cccacggcct     4260

cgccaccacc agccccacct ggcctccact tggtggcccc agccccgatc ccagcgccgc     4320

cgagctgacc ccactctgag agcctggccg agctggcagc atggagccct cggctcccca     4380

gactttgccg aggggctgct ccggaccccg ttgtgagccg gcctcctgtc tgcatgcccc     4440

ctgtggccac caggctccga ggggccgtgg tgactcttga tcaaagagca cagtgaactg     4500

tcccttctga gtctcccttt tctacagttg atatatttgt aactggtaca agatgaagga     4560

cagcagcttt ccatccctag ttcagagccc ccgttcccca gggtcctgtg ggctgagcgg     4620

ctggggctgg ggctgcccac gtgtggcctc cgctggctct gcctgctcct gcaacagtgc     4680

ggtccctgcc cggagaactc aggaggcctg cagaagagaa ctgattggtg gtcgaagcac     4740

catcttcaca gatgttcagg ggcagtgggg ggctccaggc acggtcaatg aaggaaacag     4800

tgcctgtcca cccaccctgc gtgtcactgt ggcggcctgg ctgtcgctgc tttttgtcct     4860

ctgccgtgtt tgcgcggcct cagtgccctc cctggtgcgt ctgcgctggg gccctcagtg     4920

ctcggggcct tggggtgcat gggtgccgcc ctgggcagct agagtgtctc agcccggtgc     4980

tgggcctggc cgaggggcgg aggcacagct gcttccagca gccagcattc agtggccttg     5040

tcaccaagct ccacacctcc tcctggtgct ggctttggtg acatcacaag gcccctccag     5100

gtgcaggggc ttctgtttgg caggcccctg ccagggagga cctggtggcc tcctcattct     5160

cttttgccat tggaatgtcc ccttgcagtt ctcttctctt tttttttttt tttgagatgg     5220

agtttcactc ttgctgccca ggctggagtg cagtggctca atctcgggtc actgcaacct     5280

ccgcctcccg ggttcaagtg atcgtcctgc cttaggctcc tgagtagctg gggattacag     5340

gtgcctacca gcatgctcgg ctaatttttt tgtattttta gtagagaagg gatttcacca     5400

tgttggccgg gctggtctca aactcctaag gtcatccacc tgcctcggcc tcccagagtg     5460

ctgagattac aggcgtgagc ctccgcgccc ggcccccttg cagttctctc tgatttggtt     5520

tgttctgtct caggcttctg tggcaggact ggcccaggga ggaggaagcc agcagcacac     5580

ctggggaatg gggtcccggc cgggaggctt ggcctctggg cgacctcgtc ctgttttttt     5640

tgtttgtttg tttgtttttt taaaggtaaa cctcctgggc cgcagatggc aaagggagtg     5700

cctgggcctg gtgacccagg gctggatcca cccctgcgga gccctgggcc aggcaggtgt     5760

ctgctgctca cctggctctg gagggctgcc ctgcagctgg gcctggggac aggtcggctg     5820

tggggcagct cagtaccctc cctgaggctc acggtggctc cgagcatgag gtccgcctcc     5880

tgggcgagac ccagcagtgg acagcatggt cctcacaccc agctccctgc acacccaggc     5940

cagccacccc tcccgctcgt gcacaggcac gcagatgcgc tcacacgtac acacacacaa     6000

atgcacgccc acttgcacat gctcacgcac atgttcacac atgcacactc acgctcacac     6060

atgctgtcac gcatacacac acgcacatac tcctgcacat gttcccatgc atgtgtgtgc     6120

actcggaccg agcatctccc acgcacctct accccacccc aagcacctct ctccccccat     6180

gcacctctcc ccaacaacac acacagcccc ctgcaccgcc cgccccccgc ccccaccaag     6240

gccccagcct ctggccatca gtcctggtgc cagagctttg cgtgaagttc gggccgcaga     6300

gtggcccgct gggactccca tgtgctgccg tctgatgtgc tcagatgggc tcatcgttgg     6360

ttcgttttta ctgtatattt atagtaataa aatcatgcag caata                     6405


<210>  21
<211>  3934
<212>  DNA
<213>  Homo sapiens

<400>  21
gtgggggctc gaggcgcctc cgcggccgtg gacgagcgtc cgtgcggcct ggtccgggcc       60

atgtccgcgt gaggaccccg ccgctgtcgc cgctcccgtt ccggccctgg cccctctgcc      120

cggcagcgcc gcgcaccatg ggctccattc tcagccgccg catcgcgggg gtggaggaca      180

tcgacatcca ggcgaactcg gcctatcgct accctccgaa gtccggaaac tactttgctt      240

cgcacttttt catgggagga gagaaattcg acacccccca ccctgaaggt tacctctttg      300

gagagaacat ggatctgaac ttcctgggca gccgcccggt ccagtttccc tacgtcactc      360

ctgcccccca cgagcccgtg aagacgctgc ggagcctggt gaacatccgc aaagactccc      420

tgcggctggt gaggtacaaa gacgatgccg acagccccac cgaggacggc gacaagcccc      480

gggtgctcta cagcctggag ttcaccttcg acgccgatgc ccgcgtggcc atcaccatct      540

actgccaggc atcggaggag ttcctgaacg gcagggcagt atacagcccc aagagcccct      600

cgctacagtc cgagaccgtc cactacaaga gaggggtgag ccagcagttc tccctgccct      660

ccttcaagat tgacttctcg gaatggaagg atgacgagct gaactttgac ctggaccggg      720

gcgtgtttcc agtagtcatc caggctgtgg tggacgaagg agatgtggtg gaagtgactg      780

gccacgccca cgtgctcttg gctgcctttg aaaagcacat ggacggcagc ttctctgtga      840

agcctttaaa gcagaagcaa attgtggacc gggtcagcta cctcctgcag gagatctatg      900

gcattgagaa caagaacaac caggagacca agccctcgga cgacgagaac agcgacaaca      960

gcaacgagtg tgtggtgtgc ctgtccgacc tgcgggacac gctgatcctg ccctgccgcc     1020

acctgtgcct ctgtacctcc tgcgccgaca cgctgcgcta ccaggccaac aactgcccca     1080

tctgccggct gcctttccgg gccctcctgc agatccgggc ggtgcggaag aagccaggag     1140

ccctgtcccc cgtgtccttc agccccgtcc tggcccagag cctggagcat gatgagcact     1200

cttgtccctt taaaaaatca aagccgcacc ccgcctccct ggccagcaag aaacctaaaa     1260

gggaaacaaa ctctgacagc gtcccacctg gctacgagcc catctcgctg ctcgaggcgc     1320

tcaacggcct ccgggctgtc tccccggcca tcccctcggc ccctctttat gaagaaatca     1380

cctattcagg catctcggac ggcctgtccc aggccagctg tcccctcgcg gctatcgacc     1440

acatcctgga cagcagccgc cagaagggca ggccgcagag caaggccccc gacagcaccc     1500

tacggtcccc gtcttccccc atccacgaag aggatgagga gaagctctcc gaggacgtgg     1560

acgcccctcc cccactgggt ggcgcagagc tggccctgcg ggaaagcagc tcccctgaga     1620

gtttcataac agaagaggtt gatgagtcgt cgtcaccaca gcaagggacc cgagcagctt     1680

ccattgagaa tgtcctgcag gacagcagcc ccgagcactg tggccgaggc ccacctgctg     1740

acatctacct gccaggacgg cccacctcca tggagacggc ccacggcctc gccaccacca     1800

gccccacctg gcctccactt ggtggcccca gccccgatcc cagcgccgcc gagctgaccc     1860

cactctgaga gcctggccga gctggcagca tggagccctc ggctccccag actttgccga     1920

ggggctgctc cggaccccgt tgtgagccgg cctcctgtct gcatgccccc tgtggccacc     1980

aggctccgag gggccgtggt gactcttgat caaagagcac agtgaactgt cccttctgag     2040

tctccctttt ctacagttga tatatttgta actggtacaa gatgaaggac agcagctttc     2100

catccctagt tcagagcccc cgttccccag ggtcctgtgg gctgagcggc tggggctggg     2160

gctgcccacg tgtggcctcc gctggctctg cctgctcctg caacagtgcg gtccctgccc     2220

ggagaactca ggaggcctgc agaagagaac tgattggtgg tcgaagcacc atcttcacag     2280

atgttcaggg gcagtggggg gctccaggca cggtcaatga aggaaacagt gcctgtccac     2340

ccaccctgcg tgtcactgtg gcggcctggc tgtcgctgct ttttgtcctc tgccgtgttt     2400

gcgcggcctc agtgccctcc ctggtgcgtc tgcgctgggg ccctcagtgc tcggggcctt     2460

ggggtgcatg ggtgccgccc tgggcagcta gagtgtctca gcccggtgct gggcctggcc     2520

gaggggcgga ggcacagctg cttccagcag ccagcattca gtggccttgt caccaagctc     2580

cacacctcct cctggtgctg gctttggtga catcacaagg cccctccagg tgcaggggct     2640

tctgtttggc aggcccctgc cagggaggac ctggtggcct cctcattctc ttttgccatt     2700

ggaatgtccc cttgcagttc tcttctcttt tttttttttt ttgagatgga gtttcactct     2760

tgctgcccag gctggagtgc agtggctcaa tctcgggtca ctgcaacctc cgcctcccgg     2820

gttcaagtga tcgtcctgcc ttaggctcct gagtagctgg ggattacagg tgcctaccag     2880

catgctcggc taattttttt gtatttttag tagagaaggg atttcaccat gttggccggg     2940

ctggtctcaa actcctaagg tcatccacct gcctcggcct cccagagtgc tgagattaca     3000

ggcgtgagcc tccgcgcccg gcccccttgc agttctctct gatttggttt gttctgtctc     3060

aggcttctgt ggcaggactg gcccagggag gaggaagcca gcagcacacc tggggaatgg     3120

ggtcccggcc gggaggcttg gcctctgggc gacctcgtcc tgtttttttt gtttgtttgt     3180

ttgttttttt aaaggtaaac ctcctgggcc gcagatggca aagggagtgc ctgggcctgg     3240

tgacccaggg ctggatccac ccctgcggag ccctgggcca ggcaggtgtc tgctgctcac     3300

ctggctctgg agggctgccc tgcagctggg cctggggaca ggtcggctgt ggggcagctc     3360

agtaccctcc ctgaggctca cggtggctcc gagcatgagg tccgcctcct gggcgagacc     3420

cagcagtgga cagcatggtc ctcacaccca gctccctgca cacccaggcc agccacccct     3480

cccgctcgtg cacaggcacg cagatgcgct cacacgtaca cacacacaaa tgcacgccca     3540

cttgcacatg ctcacgcaca tgttcacaca tgcacactca cgctcacaca tgctgtcacg     3600

catacacaca cgcacatact cctgcacatg ttcccatgca tgtgtgtgca ctcggaccga     3660

gcatctccca cgcacctcta ccccacccca agcacctctc tccccccatg cacctctccc     3720

caacaacaca cacagccccc tgcaccgccc gccccccgcc cccaccaagg ccccagcctc     3780

tggccatcag tcctggtgcc agagctttgc gtgaagttcg ggccgcagag tggcccgctg     3840

ggactcccat gtgctgccgt ctgatgtgct cagatgggct catcgttggt tcgtttttac     3900

tgtatattta tagtaataaa atcatgcagc aata                                 3934


<210>  22
<211>  554
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Ser Ile Leu Ser Arg Arg Ile Ala Gly Val Glu Asp Ile Asp 
1               5                   10                  15      


Ile Gln Ala Asn Ser Ala Tyr Arg Tyr Pro Pro Lys Ser Gly Asn Tyr 
            20                  25                  30          


Phe Ala Ser His Phe Phe Met Gly Gly Glu Lys Phe Asp Thr Pro His 
        35                  40                  45              


Pro Glu Gly Tyr Leu Phe Gly Glu Asn Met Asp Leu Asn Phe Leu Gly 
    50                  55                  60                  


Ser Arg Pro Val Gln Phe Pro Tyr Val Thr Pro Ala Pro His Glu Pro 
65                  70                  75                  80  


Val Lys Thr Leu Arg Ser Leu Val Asn Ile Arg Lys Asp Ser Leu Arg 
                85                  90                  95      


Leu Val Arg Tyr Lys Asp Asp Ala Asp Ser Pro Thr Glu Asp Gly Asp 
            100                 105                 110         


Lys Pro Arg Val Leu Tyr Ser Leu Glu Phe Thr Phe Asp Ala Asp Ala 
        115                 120                 125             


Arg Val Ala Ile Thr Ile Tyr Cys Gln Ala Ser Glu Glu Phe Leu Asn 
    130                 135                 140                 


Gly Arg Ala Val Tyr Ser Pro Lys Ser Pro Ser Leu Gln Ser Glu Thr 
145                 150                 155                 160 


Val His Tyr Lys Arg Gly Val Ser Gln Gln Phe Ser Leu Pro Ser Phe 
                165                 170                 175     


Lys Ile Asp Phe Ser Glu Trp Lys Asp Asp Glu Leu Asn Phe Asp Leu 
            180                 185                 190         


Asp Arg Gly Val Phe Pro Val Val Ile Gln Ala Val Val Asp Glu Gly 
        195                 200                 205             


Asp Val Val Glu Val Thr Gly His Ala His Val Leu Leu Ala Ala Phe 
    210                 215                 220                 


Glu Lys His Met Asp Gly Ser Phe Ser Val Lys Pro Leu Lys Gln Lys 
225                 230                 235                 240 


Gln Ile Val Asp Arg Val Ser Tyr Leu Leu Gln Glu Ile Tyr Gly Ile 
                245                 250                 255     


Glu Asn Lys Asn Asn Gln Glu Thr Lys Pro Ser Asp Asp Glu Asn Ser 
            260                 265                 270         


Asp Asn Ser Asn Glu Cys Val Val Cys Leu Ser Asp Leu Arg Asp Thr 
        275                 280                 285             


Leu Ile Leu Pro Cys Arg His Leu Cys Leu Cys Thr Ser Cys Ala Asp 
    290                 295                 300                 


Thr Leu Arg Tyr Gln Ala Asn Asn Cys Pro Ile Cys Arg Leu Pro Phe 
305                 310                 315                 320 


Arg Ala Leu Leu Gln Ile Arg Ala Val Arg Lys Lys Pro Gly Ala Leu 
                325                 330                 335     


Ser Pro Val Ser Phe Ser Pro Val Leu Ala Gln Ser Leu Glu His Asp 
            340                 345                 350         


Glu His Ser Asn Ser Asp Ser Val Pro Pro Gly Tyr Glu Pro Ile Ser 
        355                 360                 365             


Leu Leu Glu Ala Leu Asn Gly Leu Arg Ala Val Ser Pro Ala Ile Pro 
    370                 375                 380                 


Ser Ala Pro Leu Tyr Glu Glu Ile Thr Tyr Ser Gly Ile Ser Asp Gly 
385                 390                 395                 400 


Leu Ser Gln Ala Ser Cys Pro Leu Ala Ala Ile Asp His Ile Leu Asp 
                405                 410                 415     


Ser Ser Arg Gln Lys Gly Arg Pro Gln Ser Lys Ala Pro Asp Ser Thr 
            420                 425                 430         


Leu Arg Ser Pro Ser Ser Pro Ile His Glu Glu Asp Glu Glu Lys Leu 
        435                 440                 445             


Ser Glu Asp Val Asp Ala Pro Pro Pro Leu Gly Gly Ala Glu Leu Ala 
    450                 455                 460                 


Leu Arg Glu Ser Ser Ser Pro Glu Ser Phe Ile Thr Glu Glu Val Asp 
465                 470                 475                 480 


Glu Ser Ser Ser Pro Gln Gln Gly Thr Arg Ala Ala Ser Ile Glu Asn 
                485                 490                 495     


Val Leu Gln Asp Ser Ser Pro Glu His Cys Gly Arg Gly Pro Pro Ala 
            500                 505                 510         


Asp Ile Tyr Leu Pro Gly Arg Pro Thr Ser Met Glu Thr Ala His Gly 
        515                 520                 525             


Leu Ala Thr Thr Ser Pro Thr Trp Pro Pro Leu Gly Gly Pro Ser Pro 
    530                 535                 540                 


Asp Pro Ser Ala Ala Glu Leu Thr Pro Leu 
545                 550                 


<210>  23
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Ser Ile Leu Ser Arg Arg Ile Ala Gly Val Glu Asp Ile Asp 
1               5                   10                  15      


Ile Gln Ala Asn Ser Ala Tyr Arg Tyr Pro Pro Lys Ser Gly Asn Tyr 
            20                  25                  30          


Phe Ala Ser His Phe Phe Met Gly Gly Glu Lys Phe Asp Thr Pro His 
        35                  40                  45              


Pro Glu Gly Tyr Leu Phe Gly Glu Asn Met Asp Leu Asn Phe Leu Gly 
    50                  55                  60                  


Ser Arg Pro Val Gln Phe Pro Tyr Val Thr Pro Ala Pro His Glu Pro 
65                  70                  75                  80  


Val Lys Thr Leu Arg Ser Leu Val Asn Ile Arg Lys Asp Ser Leu Arg 
                85                  90                  95      


Leu Val Arg Tyr Lys Asp Asp Ala Asp Ser Pro Thr Glu Asp Gly Asp 
            100                 105                 110         


Lys Pro Arg Val Leu Tyr Ser Leu Glu Phe Thr Phe Asp Ala Asp Ala 
        115                 120                 125             


Arg Val Ala Ile Thr Ile Tyr Cys Gln Ala Ser Glu Glu Phe Leu Asn 
    130                 135                 140                 


Gly Arg Ala Val Tyr Ser Pro Lys Ser Pro Ser Leu Gln Ser Glu Thr 
145                 150                 155                 160 


Val His Tyr Lys Arg Gly Val Ser Gln Gln Phe Ser Leu Pro Ser Phe 
                165                 170                 175     


Lys Ile Asp Phe Ser Glu Trp Lys Asp Asp Glu Leu Asn Phe Asp Leu 
            180                 185                 190         


Asp Arg Gly Val Phe Pro Val Val Ile Gln Ala Val Val Asp Glu Gly 
        195                 200                 205             


Asp Val Val Glu Val Thr Gly His Ala His Val Leu Leu Ala Ala Phe 
    210                 215                 220                 


Glu Lys His Met Asp Gly Ser Phe Ser Val Lys Pro Leu Lys Gln Lys 
225                 230                 235                 240 


Gln Ile Val Asp Arg Val Ser Tyr Leu Leu Gln Glu Ile Tyr Gly Ile 
                245                 250                 255     


Glu Asn Lys Asn Asn Gln Glu Thr Lys Pro Ser Asp Asp Glu Asn Ser 
            260                 265                 270         


Asp Asn Ser Asn Glu Cys Val Val Cys Leu Ser Asp Leu Arg Asp Thr 
        275                 280                 285             


Leu Ile Leu Pro Cys Arg His Leu Cys Leu Cys Thr Ser Cys Ala Asp 
    290                 295                 300                 


Thr Leu Arg Tyr Gln Ala Asn Asn Cys Pro Ile Cys Arg Leu Pro Phe 
305                 310                 315                 320 


Arg Ala Leu Leu Gln Ile Arg Ala Val Arg Lys Lys Pro Gly Ala Leu 
                325                 330                 335     


Ser Pro Val Ser Phe Ser Pro Val Leu Ala Gln Ser Leu Glu His Asp 
            340                 345                 350         


Glu His Ser Cys Pro Phe Lys Lys Ser Lys Pro His Pro Ala Ser Leu 
        355                 360                 365             


Ala Ser Lys Lys Pro Lys Arg Glu Thr Asn Ser Asp Ser Val Pro Pro 
    370                 375                 380                 


Gly Tyr Glu Pro Ile Ser Leu Leu Glu Ala Leu Asn Gly Leu Arg Ala 
385                 390                 395                 400 


Val Ser Pro Ala Ile Pro Ser Ala Pro Leu Tyr Glu Glu Ile Thr Tyr 
                405                 410                 415     


Ser Gly Ile Ser Asp Gly Leu Ser Gln Ala Ser Cys Pro Leu Ala Ala 
            420                 425                 430         


Ile Asp His Ile Leu Asp Ser Ser Arg Gln Lys Gly Arg Pro Gln Ser 
        435                 440                 445             


Lys Ala Pro Asp Ser Thr Leu Arg Ser Pro Ser Ser Pro Ile His Glu 
    450                 455                 460                 


Glu Asp Glu Glu Lys Leu Ser Glu Asp Val Asp Ala Pro Pro Pro Leu 
465                 470                 475                 480 


Gly Gly Ala Glu Leu Ala Leu Arg Glu Ser Ser Ser Pro Glu Ser Phe 
                485                 490                 495     


Ile Thr Glu Glu Val Asp Glu Ser Ser Ser Pro Gln Gln Gly Thr Arg 
            500                 505                 510         


Ala Ala Ser Ile Glu Asn Val Leu Gln Asp Ser Ser Pro Glu His Cys 
        515                 520                 525             


Gly Arg Gly Pro Pro Ala Asp Ile Tyr Leu Pro Ala Leu Gly Pro Asp 
    530                 535                 540                 


Ser Cys Ser Val Gly Ile Asp Glu 
545                 550         


<210>  24
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Ser Ile Leu Ser Arg Arg Ile Ala Gly Val Glu Asp Ile Asp 
1               5                   10                  15      


Ile Gln Ala Asn Ser Ala Tyr Arg Tyr Pro Pro Lys Ser Gly Asn Tyr 
            20                  25                  30          


Phe Ala Ser His Phe Phe Met Gly Gly Glu Lys Phe Asp Thr Pro His 
        35                  40                  45              


Pro Glu Gly Tyr Leu Phe Gly Glu Asn Met Asp Leu Asn Phe Leu Gly 
    50                  55                  60                  


Ser Arg Pro Val Gln Phe Pro Tyr Val Thr Pro Ala Pro His Glu Pro 
65                  70                  75                  80  


Val Lys Thr Leu Arg Ser Leu Val Asn Ile Arg Lys Asp Ser Leu Arg 
                85                  90                  95      


Leu Val Arg Tyr Lys Asp Asp Ala Asp Ser Pro Thr Glu Asp Gly Asp 
            100                 105                 110         


Lys Pro Arg Val Leu Tyr Ser Leu Glu Phe Thr Phe Asp Ala Asp Ala 
        115                 120                 125             


Arg Val Ala Ile Thr Ile Tyr Cys Gln Ala Ser Glu Glu Phe Leu Asn 
    130                 135                 140                 


Gly Arg Ala Val Tyr Ser Pro Lys Ser Pro Ser Leu Gln Ser Glu Thr 
145                 150                 155                 160 


Val His Tyr Lys Arg Gly Val Ser Gln Gln Phe Ser Leu Pro Ser Phe 
                165                 170                 175     


Lys Ile Asp Phe Ser Glu Trp Lys Asp Asp Glu Leu Asn Phe Asp Leu 
            180                 185                 190         


Asp Arg Gly Val Phe Pro Val Val Ile Gln Ala Val Val Asp Glu Gly 
        195                 200                 205             


Asp Val Val Glu Val Thr Gly His Ala His Val Leu Leu Ala Ala Phe 
    210                 215                 220                 


Glu Lys His Met Asp Gly Ser Phe Ser Val Lys Pro Leu Lys Gln Lys 
225                 230                 235                 240 


Gln Ile Val Asp Arg Val Ser Tyr Leu Leu Gln Glu Ile Tyr Gly Ile 
                245                 250                 255     


Glu Asn Lys Asn Asn Gln Glu Thr Lys Pro Ser Asp Asp Glu Asn Ser 
            260                 265                 270         


Asp Asn Ser Asn Glu Cys Val Val Cys Leu Ser Asp Leu Arg Asp Thr 
        275                 280                 285             


Leu Ile Leu Pro Cys Arg His Leu Cys Leu Cys Thr Ser Cys Ala Asp 
    290                 295                 300                 


Thr Leu Arg Tyr Gln Ala Asn Asn Cys Pro Ile Cys Arg Leu Pro Phe 
305                 310                 315                 320 


Arg Ala Leu Leu Gln Ile Arg Ala Val Arg Lys Lys Pro Gly Ala Leu 
                325                 330                 335     


Ser Pro Val Ser Phe Ser Pro Val Leu Ala Gln Ser Leu Glu His Asp 
            340                 345                 350         


Glu His Ser Asn Ser Asp Ser Val Pro Pro Gly Tyr Glu Pro Ile Ser 
        355                 360                 365             


Leu Leu Glu Ala Leu Asn Gly Leu Arg Ala Val Ser Pro Ala Ile Pro 
    370                 375                 380                 


Ser Ala Pro Leu Tyr Glu Glu Ile Thr Tyr Ser Gly Ile Ser Asp Gly 
385                 390                 395                 400 


Leu Ser Gln Ala Ser Cys Pro Leu Ala Ala Ile Asp His Ile Leu Asp 
                405                 410                 415     


Ser Ser Arg Gln Lys Gly Arg Pro Gln Ser Lys Ala Pro Asp Ser Thr 
            420                 425                 430         


Leu Arg Ser Pro Ser Ser Pro Ile His Glu Glu Asp Glu Glu Lys Leu 
        435                 440                 445             


Ser Glu Asp Val Asp Ala Pro Pro Pro Leu Gly Gly Ala Glu Leu Ala 
    450                 455                 460                 


Leu Arg Glu Ser Ser Ser Pro Glu Ser Phe Ile Thr Glu Glu Val Asp 
465                 470                 475                 480 


Glu Ser Ser Ser Pro Gln Gln Gly Thr Arg Ala Ala Ser Ile Glu Asn 
                485                 490                 495     


Val Leu Gln Asp Ser Ser Pro Glu His Cys Gly Arg Gly Pro Pro Ala 
            500                 505                 510         


Asp Ile Tyr Leu Pro Ala Leu Gly Pro Asp Ser Cys Ser Val Gly Ile 
        515                 520                 525             


Asp Glu 
    530 


<210>  25
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gly Ser Ile Leu Ser Arg Arg Ile Ala Gly Val Glu Asp Ile Asp 
1               5                   10                  15      


Ile Gln Ala Asn Ser Ala Tyr Arg Tyr Pro Pro Lys Ser Gly Asn Tyr 
            20                  25                  30          


Phe Ala Ser His Phe Phe Met Gly Gly Glu Lys Phe Asp Thr Pro His 
        35                  40                  45              


Pro Glu Gly Tyr Leu Phe Gly Glu Asn Met Asp Leu Asn Phe Leu Gly 
    50                  55                  60                  


Ser Arg Pro Val Gln Phe Pro Tyr Val Thr Pro Ala Pro His Glu Pro 
65                  70                  75                  80  


Val Lys Thr Leu Arg Ser Leu Val Asn Ile Arg Lys Asp Ser Leu Arg 
                85                  90                  95      


Leu Val Arg Tyr Lys Asp Asp Ala Asp Ser Pro Thr Glu Asp Gly Asp 
            100                 105                 110         


Lys Pro Arg Val Leu Tyr Ser Leu Glu Phe Thr Phe Asp Ala Asp Ala 
        115                 120                 125             


Arg Val Ala Ile Thr Ile Tyr Cys Gln Ala Ser Glu Glu Phe Leu Asn 
    130                 135                 140                 


Gly Arg Ala Val Tyr Ser Pro Lys Ser Pro Ser Leu Gln Ser Glu Thr 
145                 150                 155                 160 


Val His Tyr Lys Arg Gly Val Ser Gln Gln Phe Ser Leu Pro Ser Phe 
                165                 170                 175     


Lys Ile Asp Phe Ser Glu Trp Lys Asp Asp Glu Leu Asn Phe Asp Leu 
            180                 185                 190         


Asp Arg Gly Val Phe Pro Val Val Ile Gln Ala Val Val Asp Glu Gly 
        195                 200                 205             


Asp Val Val Glu Val Thr Gly His Ala His Val Leu Leu Ala Ala Phe 
    210                 215                 220                 


Glu Lys His Met Asp Gly Ser Phe Ser Val Lys Pro Leu Lys Gln Lys 
225                 230                 235                 240 


Gln Ile Val Asp Arg Val Ser Tyr Leu Leu Gln Glu Ile Tyr Gly Ile 
                245                 250                 255     


Glu Asn Lys Asn Asn Gln Glu Thr Lys Pro Ser Asp Asp Glu Asn Ser 
            260                 265                 270         


Asp Asn Ser Asn Glu Cys Val Val Cys Leu Ser Asp Leu Arg Asp Thr 
        275                 280                 285             


Leu Ile Leu Pro Cys Arg His Leu Cys Leu Cys Thr Ser Cys Ala Asp 
    290                 295                 300                 


Thr Leu Arg Tyr Gln Ala Asn Asn Cys Pro Ile Cys Arg Leu Pro Phe 
305                 310                 315                 320 


Arg Ala Leu Leu Gln Ile Arg Ala Val Arg Lys Lys Pro Gly Ala Leu 
                325                 330                 335     


Ser Pro Val Ser Phe Ser Pro Val Leu Ala Gln Ser Leu Glu His Asp 
            340                 345                 350         


Glu His Ser Cys Pro Phe Lys Lys Ser Lys Pro His Pro Ala Ser Leu 
        355                 360                 365             


Ala Ser Lys Lys Pro Lys Arg Glu Thr Asn Ser Asp Ser Val Pro Pro 
    370                 375                 380                 


Gly Tyr Glu Pro Ile Ser Leu Leu Glu Ala Leu Asn Gly Leu Arg Ala 
385                 390                 395                 400 


Val Ser Pro Ala Ile Pro Ser Ala Pro Leu Tyr Glu Glu Ile Thr Tyr 
                405                 410                 415     


Ser Gly Ile Ser Asp Gly Leu Ser Gln Ala Ser Cys Pro Leu Ala Ala 
            420                 425                 430         


Ile Asp His Ile Leu Asp Ser Ser Arg Gln Lys Gly Arg Pro Gln Ser 
        435                 440                 445             


Lys Ala Pro Asp Ser Thr Leu Arg Ser Pro Ser Ser Pro Ile His Glu 
    450                 455                 460                 


Glu Asp Glu Glu Lys Leu Ser Glu Asp Val Asp Ala Pro Pro Pro Leu 
465                 470                 475                 480 


Gly Gly Ala Glu Leu Ala Leu Arg Glu Ser Ser Ser Pro Glu Ser Phe 
                485                 490                 495     


Ile Thr Glu Glu Val Asp Glu Ser Ser Ser Pro Gln Gln Gly Thr Arg 
            500                 505                 510         


Ala Ala Ser Ile Glu Asn Val Leu Gln Asp Ser Ser Pro Glu His Cys 
        515                 520                 525             


Gly Arg Gly Pro Pro Ala Asp Ile Tyr Leu Pro Gly Arg Pro Thr Ser 
    530                 535                 540                 


Met Glu Thr Ala His Gly Leu Ala Thr Thr Ser Pro Thr Trp Pro Pro 
545                 550                 555                 560 


Leu Gly Gly Pro Ser Pro Asp Pro Ser Ala Ala Glu Leu Thr Pro Leu 
                565                 570                 575     


<210>  26
<211>  6382
<212>  DNA
<213>  Homo sapiens

<400>  26
cggtgcattc tgggtcctgg caatatggcg tcctccttga tgggctgatg agatgagttt       60

cactgtagct ccaaaccaga gggcaaagct cccatgaccc aataagccca cattgtccct      120

ttcctccgtg gttccgtgtc gcccgtttct caggactcgt tctcaggcag gagagagcct      180

cggggctgaa ggccaggacc agccaggccg cgcggacctg aggttgagga accgggtgca      240

ggcgagcacg atgggccggt cgtggctctg gttgcagcag ctcagacgag tgcgggaccc      300

gcagggctga gagtggctgg aggagaccca gggccctttg aacccgatcc cttggccgga      360

gacctcagcc cagtcggccc agtgggcgaa ccggcaccaa gagcggcctg cctgtcttcg      420

gaactgctga ggcggtggag gccgagagca gggtcatcgt gaggcctgaa gtctcttacg      480

cttttggcag ctcccctcgc agcccctctg gaaacgtaca gcctcaggag cagccagtgg      540

cttgggacct ggggtggtgt gtgtctgcgg agcttcttgg gctgccccat ttcctagcgg      600

cccccacctc cccacttccc gctcagagtt agagataagg atctcagact tttgcctgag      660

taagggtctc cgcactcttt atccatttgg ttttcgattt cccgtttttg tttcttattt      720

caccaattct ggtacacgct agtttttaag gctggaggtt ctcgagcgct tgctgccaag      780

gactccccca ccccctcccc cactgatgga gtccgaaatg ctgcaatcgc ctcttctggg      840

cctgggggag gaagatgagg ctgatcttac agactggaac ctacctttgg cttttatgaa      900

aaagaggcac tgtgagaaaa ttgaaggctc caaatcctta gctcagagct ggaggatgaa      960

ggatcggatg aagacagtca gtgttgcctt agttttgtgc ctgaatgttg gtgtggaccc     1020

tcccgatgtg gtgaagacca cgccctgtgc acgcttggaa tgctggatcg atcctctgtc     1080

gatgggtcct cagaaagctc tggaaaccat cggtgcaaat ttacagaagc agtacgagaa     1140

ctggcagcca agggcccggt acaagcagag ccttgaccca actgtggatg aagtcaagaa     1200

gctctgcacg tccttacgtc gcaacgccaa ggaggagcga gtcctctttc actacaatgg     1260

ccacggggtg ccccggccca cagtcaacgg ggaggtctgg gtcttcaaca agaactacac     1320

gcagtacatc cctctgtcca tatatgacct gcagacgtgg atgggcagcc cgtcgatctt     1380

cgtctacgac tgctccaatg ctggcttgat cgtcaagtcc ttcaagcagt tcgcactaca     1440

gcgggagcag gagctggagg tagctgcaat caacccaaat caccctcttg ctcagatgcc     1500

tttgcctccg tcgatgaaaa actgcatcca gctggcagcc tgcgaggcca ccgagctgct     1560

gcccatgatc cccgacctcc cggctgacct attcacctcc tgcctcacca cccccatcaa     1620

gatcgccctg cgctggtttt gcatgcagaa atgtgtcagt ctggtgcctg gcgtcacact     1680

ggatttgata gaaaagatcc ctggccgcct gaacgacagg aggacgcccc tgggtgaact     1740

gaactggatc ttcacagcca tcacagacac catcgcgtgg aacgtgctcc cccgggatct     1800

cttccaaaag ctcttcagac aggacttgct ggtggctagt ctgtttcgaa attttttatt     1860

ggcggaaagg attatgaggt cgtataactg cactcccgtc agcagcccgc gtctgccgcc     1920

cacgtacatg cacgccatgt ggcaagcctg ggacctggct gttgacatct gtctgtctca     1980

gctgccgacg atcatcgagg aaggcactgc gtttcggcac agcccgttct tcgccgagca     2040

gctgaccgca ttccaggtgt ggctcaccat gggcgtggag aaccgaaacc cacccgaaca     2100

gctgcccatc gtcctgcagg tgctgttaag ccaagtgcac cggctgagag cattggactt     2160

gcttggaaga tttttggacc tgggtccctg ggcagtgagc ctggccttgt ctgtcggcat     2220

cttcccctac gtgctgaagc tgctccagag ctcggcccga gagctgcggc cacttctcgt     2280

tttcatctgg gccaagatcc tcgcagtgga cagcgagctg gtggtggctc tgagtcatct     2340

tgtggttcag tatgaaagca atttctgcac cgtggccctg cagttcatag aagaggaaaa     2400

gaactacgcc ttgccttctc cagcaaccac agagggaggg agtttgaccc cagtgcgaga     2460

cagcccgtgc acccccagac ttcgttctgt gagctcctat ggaaacatcc gtgctgtcgc     2520

cacagccagg agcctcaaca aatctttgca gaacctgagt ttgacagagg aatctggtgg     2580

cgcggtggcg ttctcccccg gaaacctcag caccagcagc agcgccagca gcaccctggg     2640

cagccccgag aatgaggagc atatcctgtc cttcgagacc atcgacaaga tgcgccgcgc     2700

cagctcctac tcctccctca actccctcat cggagtttcc tttaacagtg tttacactca     2760

gatttggaga gtcctgctgc acctggctgc tgacccctat ccagaggtct cggacgtggc     2820

catgaaagta ctcaacagca tcgcctacaa ggccaccgtg aacgcccggc cgcagcgcgt     2880

cctggacacc tcctccctca cgcagtcggc ccccgccagc cccaccaaca agggcgtgca     2940

catccaccag gcggggggct cccctccggc gtccagcacc agcagctcca gcctgaccaa     3000

cgatgtggcc aagcagccgg tcagccgaga cttgccttct ggccggccgg gcaccacagg     3060

ccccgctggg gcgcagtaca cccctcactc ccaccagttc ccccggacac ggaagatgtt     3120

cgacaagggc ccagagcaga ctgcggacga cgcggacgat gctgctggac acaaaagttt     3180

catctccgcc acggtgcaga cggggttctg cgactggagc gcccgctatt ttgcccagcc     3240

cgtcatgaag atcccagaag agcacgacct ggagagtcag atccgcaagg agcgggagtg     3300

gcggttcctg cgaaacagcc gtgtcaggag gcaggcccag caagtcattc agaagggcat     3360

tacgagattg gacgaccaaa tatttctgaa caggaacccc ggcgtcccct ctgtggtgaa     3420

attccacccc ttcacgccgt gcatcgccgt agccgacaag gacagcatct gcttttggga     3480

ctgggagaaa ggggagaagc tggattattt ccacaatggg aaccctcggt acacgagggt     3540

cactgccatg gagtatctga acggccagga ctgctcgctt ctgctgacgg ccacagacga     3600

tggtgccatc agggtctgga agaattttgc tgatttggaa aagaacccag agatggtgac     3660

cgcgtggcag gggctctcgg acatgctgcc aacgacgcga ggagctggga tggtggtgga     3720

ctgggagcag gagaccggcc tcctcatgag ctcaggagac gtgcggatcg tccggatctg     3780

ggacacagac cgtgagatga aggtgcagga catccctacg ggcgcagaca gctgtgtgac     3840

gagtctgtcc tgtgattccc accgctcact catcgtggct ggcctcggtg acggctccat     3900

ccgcgtctac gacagaagga tggcactcag cgaatgccgc gtcatgacgt accgggagca     3960

cacagcctgg gtggtgaagg cctccctgca gaagcgtccc gacggccaca tcgtgagtgt     4020

gagcgtcaat ggagatgtgc gcatctttga tccccggatg cctgagtcgg taaatgtgct     4080

tcagatcgtg aaggggctga cggccctgga catccacccc caggcggacc tgatcgcatg     4140

tggctccgtc aatcagttca ccgccatcta caacagcagc ggagagctca tcaacaacat     4200

caagtactac gacggcttca tgggccagcg ggtcggcgcc atcagctgcc tggccttcca     4260

cccgcactgg cctcacctgg ccgtgggaag caacgactac tacatctccg tgtactcggt     4320

ggagaagcgt gtcagatagc ggcgtgaccc gggcccacca ggccacggcc gcctgctgta     4380

catagtgaag ctgtcactcg ccggggcacg gggcgtcggc tgctgcggcc ccgcagtgtg     4440

aacgttggct gctgccttag ctgctgatga cggcaggagg gccctgctac tcgcttttgt     4500

ctgtcttcgc tgtcgtgtct ggaatgtcag ggaaggggag ggctcgggtt gacggtggct     4560

tcccactgag caccagcatc caggtgcacc cccgcggcca cggcgcctct gtccctctcc     4620

tgttctgtgt ttctctgaga cgctgaaagg ggaaacacct cactttattt ccatgtaatc     4680

agagcattag ctgcagaaaa accccccgac agagccctgg cggagaggca ggcgctgggg     4740

ctcctacggg tccctggggc agctgtcccc atcaggccaa gagcgagcga gaggcgctgc     4800

cccagccagg cccaccacct ctcacagtca gtgcacgcaa gcagggacat ttcctagcca     4860

gctgggggac actggaaatt cgggaaacca agagagagga agaaggagac gcccctccaa     4920

ctggcgggtg tgaaggaagc cgcccagggg tccgggctgt ccttggccgc tggcagcatc     4980

actgagcagg aagcgcacag cccaccctcc ccgcacctcc aggtctctgg actccagttt     5040

tggcccctct cacacagagc tgtcagcagg ggccgctgtg gcggtgcaca ggggaggcag     5100

gtccttggcg aggtagcccc tgccttaatc cacggggctc ctttccctcc gaagggctgc     5160

tcttccccac aggcgcgggg acagcagccc gacctgtggt ctccatgcct gtgccctcac     5220

acaggtgtag cacacgcatg tgcagatggc accacggccg gcacctgggg gcacacacat     5280

gcaggcggcg tggtctccct gctctgtccc cacacgttcc tcacatacag gcaagaggca     5340

ctgccgggtc ccggacggct ccgggtgaca ccagccccgt ctccagcctt gagccgccca     5400

tgctgatgcg acctcggctg acagctgggc ctgtggtgca gacaggagct gtgtggacag     5460

tcccgcccag gaggggccgc agggcgtgta tgagcagttt tgcaaacaga acacaaccac     5520

aatgatggta ttttgaaaag tgttctttcc gtgttcgtcg ggaatcagga ttattgagag     5580

gtgaaggagc caggtggctt cattctggcg gtgagaggcc cacgaccacg ggagtgagag     5640

ctggtgtggc gaggcccggc tctcctgcgg tgtggctggt ggcctgccgt ggccaagagc     5700

atcttctggg tggatggaac cctgcctggt cacatttggc cagagacaca cctggccctc     5760

agggggctga gctggagact gagctggggc tggccgggac gtgacaaggc aggacagagg     5820

cggcccctcc gctgctcctt tttggaatgc gagctcccac cagaagaagg ttccggcacg     5880

aatcccatcc ccacgtctgg gccgagaaag cagcccgggt ccggaaggtg tagagagtcc     5940

cggcctcact cagctcacag ggcgtgccag gcggcaacac cagaatcttc cagaagccca     6000

gctccacccg cacacgcagc ttcccatcca gtccttcaac tcaattctta cccaacacgc     6060

gtttctgttt gttttgagac aaaatcacca cctgtcaaaa ggcaggtggc tccagagggg     6120

tcaagacccc cccccgcccc cgctccaccc tggagcccac ccccatgggc accgcgtgcc     6180

gcctgcacgt gggctgtctt cacaggtctg atgtgaaaat tcaatcacga cgttaaccgg     6240

ctcgagagag cgccggccta gaggctcatt atctatttat tttaccaaac gcgaattgag     6300

acggactttg acaaaacacg aaatggtaat gtgaagctaa gagcagagag tgaccaacag     6360

taaacaacac gcgcagactc cg                                              6382


<210>  27
<211>  6856
<212>  DNA
<213>  Homo sapiens

<400>  27
cggtgcattc tgggtcctgg caatatggcg tcctccttga tgggctgatg agatgagttt       60

cactgtagct ccaaaccaga gggcaaagct cccatgaccc aataagccca cattgtccct      120

ttcctccgtg gttccgtgtc gcccgtttct caggactcgt tctcaggcag gagagagcct      180

cggggctgaa ggccaggacc agccaggccg cgcggacctg aggttgagga accgggtgca      240

ggcgagcacg atgggccggt cgtggctctg gttgcagcag ctcagacgag tgcgggaccc      300

gcagggctga gagtggctgg aggagaccca gggccctttg aacccgatcc cttggccgga      360

gacctcagcc cagtcggccc agtgggcgaa ccggcaccaa gagcggcctg cctgtcttcg      420

gaactgctga ggcggtggag gccgagagca gggtcatcgt gaggcctgaa gtctcttacg      480

cttttggcag ctcccctcgc agcccctctg gaaacgtaca gcctcaggag cagccagtgg      540

cttgggacct ggggtggtgt gtgtctgcgg agcttcttgg gctgccccat ttcctagcgg      600

cccccacctc cccacttccc gctcagagtt agagataagg atctcagact tttgcctgag      660

taagggtctc cgcactcttt atccatttgg ttttcgattt cccgtttttg tttcttattt      720

caccaattct ggtacacgct agtttttaag gctggaggtt ctcgagcgct tgctgccaag      780

gactccccca ccccctcccc cactgatgga gtccgaaatg ctgcaatcgc ctcttctggg      840

cctgggggag gaagatgagg ctgatcttac agactggaac ctacctttgg cttttatgaa      900

aaagaggcac tgtgagaaaa ttgaaggctc caaatcctta gctcagagct ggaggatgaa      960

ggatcggatg aagacagtca gtgttgcctt agttttgtgc ctgaatgttg gtgtggaccc     1020

tcccgatgtg gtgaagacca cgccctgtgc acgcttggaa tgctggatcg atcctctgtc     1080

gatgggtcct cagaaagctc tggaaaccat cggtgcaaat ttacagaagc agtacgagaa     1140

ctggcagcca agggcccggt acaagcagag ccttgaccca actgtggatg aagtcaagaa     1200

gctctgcacg tccttacgtc gcaacgccaa ggaggagcga gtcctctttc actacaatgg     1260

ccacggggtg ccccggccca cagtcaacgg ggaggtctgg gtcttcaaca agaactacac     1320

gcagtacatc cctctgtcca tatatgacct gcagacgtgg atgggcagcc cgtcgatctt     1380

cgtctacgac tgctccaatg ctggcttgat cgtcaagtcc ttcaagcagt tcgcactaca     1440

gcgggagcag gagctggagg tagctgcaat caacccaaat caccctcttg ctcagatgcc     1500

tttgcctccg tcgatgaaaa actgcatcca gctggcagcc tgcgaggcca ccgagctgct     1560

gcccatgatc cccgacctcc cggctgacct attcacctcc tgcctcacca cccccatcaa     1620

gatcgccctg cgctggtttt gcatgcagaa atgtgtcagt ctggtgcctg gcgtcacact     1680

ggatttgata gaaaagatcc ctggccgcct gaacgacagg aggacgcccc tgggtgaact     1740

gaactggatc ttcacagcca tcacagacac catcgcgtgg aacgtgctcc cccgggatct     1800

cttccaaaag ctcttcagac aggacttgct ggtggctagt ctgtttcgaa attttttatt     1860

ggcggaaagg attatgaggt cgtataactg cactcccgtc agcagcccgc gtctgccgcc     1920

cacgtacatg cacgccatgt ggcaagcctg ggacctggct gttgacatct gtctgtctca     1980

gctgccgacg atcatcgagg aaggcactgc gtttcggcac agcccgttct tcgccgagca     2040

gctgaccgca ttccaggtgt ggctcaccat gggcgtggag aaccgaaacc cacccgaaca     2100

gctgcccatc gtcctgcagg tgctgttaag ccaagtgcac cggctgagag cattggactt     2160

gcttggaaga tttttggacc tgggtccctg ggcagtgagc ctggccttgt ctgtcggcat     2220

cttcccctac gtgctgaagc tgctccagag ctcggcccga gagctgcggc cacttctcgt     2280

tttcatctgg gccaagatcc tcgcagtgga cagctcgtgc caagcggacc tcgtgaagga     2340

caacggccac aagtacttcc tgtcggtcct ggcggacccc tacatgccag ctgaacaccg     2400

gaccatgacg gctttcattc tcgccgtgat cgtcaacagc tatcacacgg ggcaggaagc     2460

ctgccttcag ggaaacctca ttgccatctg cctggagcag ctcaacgacc cgcacccctt     2520

gctgcgccag tgggtggcca tctgcctcgg caggatctgg cagaacttcg actcggcgag     2580

gtggtgcggc gtgagggaca gcgctcatga gaagctctac agcctcctct ccgaccccat     2640

tcccgaggtc cgctgcgcag cggtcttcgc ccttggcacg ttcgtgggca actctgcaga     2700

gaggacggac cactccacca ccatcgacca caacgtggcc atgatgctgg cccagctggt     2760

cagcgacggg agccccatgg tccggaagga gctggtggtg gctctgagtc atcttgtggt     2820

tcagtatgaa agcaatttct gcaccgtggc cctgcagttc atagaagagg aaaagaacta     2880

cgccttgcct tctccagcaa ccacagaggg agggagtttg accccagtgc gagacagccc     2940

gtgcaccccc agacttcgtt ctgtgagctc ctatggaaac atccgtgctg tcgccacagc     3000

caggagcctc aacaaatctt tgcagaacct gagtttgaca gaggaatctg gtggcgcggt     3060

ggcgttctcc cccggaaacc tcagcaccag cagcagcgcc agcagcaccc tgggcagccc     3120

cgagaatgag gagcatatcc tgtccttcga gaccatcgac aagatgcgcc gcgccagctc     3180

ctactcctcc ctcaactccc tcatcggagt ttcctttaac agtgtttaca ctcagatttg     3240

gagagtcctg ctgcacctgg ctgctgaccc ctatccagag gtctcggacg tggccatgaa     3300

agtactcaac agcatcgcct acaaggccac cgtgaacgcc cggccgcagc gcgtcctgga     3360

cacctcctcc ctcacgcagt cggcccccgc cagccccacc aacaagggcg tgcacatcca     3420

ccaggcgggg ggctcccctc cggcgtccag caccagcagc tccagcctga ccaacgatgt     3480

ggccaagcag ccggtcagcc gagacttgcc ttctggccgg ccgggcacca caggccccgc     3540

tggggcgcag tacacccctc actcccacca gttcccccgg acacggaaga tgttcgacaa     3600

gggcccagag cagactgcgg acgacgcgga cgatgctgct ggacacaaaa gtttcatctc     3660

cgccacggtg cagacggggt tctgcgactg gagcgcccgc tattttgccc agcccgtcat     3720

gaagatccca gaagagcacg acctggagag tcagatccgc aaggagcggg agtggcggtt     3780

cctgcgaaac agccgtgtca ggaggcaggc ccagcaagtc attcagaagg gcattacgag     3840

attggacgac caaatatttc tgaacaggaa ccccggcgtc ccctctgtgg tgaaattcca     3900

ccccttcacg ccgtgcatcg ccgtagccga caaggacagc atctgctttt gggactggga     3960

gaaaggggag aagctggatt atttccacaa tgggaaccct cggtacacga gggtcactgc     4020

catggagtat ctgaacggcc aggactgctc gcttctgctg acggccacag acgatggtgc     4080

catcagggtc tggaagaatt ttgctgattt ggaaaagaac ccagagatgg tgaccgcgtg     4140

gcaggggctc tcggacatgc tgccaacgac gcgaggagct gggatggtgg tggactggga     4200

gcaggagacc ggcctcctca tgagctcagg agacgtgcgg atcgtccgga tctgggacac     4260

agaccgtgag atgaaggtgc aggacatccc tacgggcgca gacagctgtg tgacgagtct     4320

gtcctgtgat tcccaccgct cactcatcgt ggctggcctc ggtgacggct ccatccgcgt     4380

ctacgacaga aggatggcac tcagcgaatg ccgcgtcatg acgtaccggg agcacacagc     4440

ctgggtggtg aaggcctccc tgcagaagcg tcccgacggc cacatcgtga gtgtgagcgt     4500

caatggagat gtgcgcatct ttgatccccg gatgcctgag tcggtaaatg tgcttcagat     4560

cgtgaagggg ctgacggccc tggacatcca cccccaggcg gacctgatcg catgtggctc     4620

cgtcaatcag ttcaccgcca tctacaacag cagcggagag ctcatcaaca acatcaagta     4680

ctacgacggc ttcatgggcc agcgggtcgg cgccatcagc tgcctggcct tccacccgca     4740

ctggcctcac ctggccgtgg gaagcaacga ctactacatc tccgtgtact cggtggagaa     4800

gcgtgtcaga tagcggcgtg acccgggccc accaggccac ggccgcctgc tgtacatagt     4860

gaagctgtca ctcgccgggg cacggggcgt cggctgctgc ggccccgcag tgtgaacgtt     4920

ggctgctgcc ttagctgctg atgacggcag gagggccctg ctactcgctt ttgtctgtct     4980

tcgctgtcgt gtctggaatg tcagggaagg ggagggctcg ggttgacggt ggcttcccac     5040

tgagcaccag catccaggtg cacccccgcg gccacggcgc ctctgtccct ctcctgttct     5100

gtgtttctct gagacgctga aaggggaaac acctcacttt atttccatgt aatcagagca     5160

ttagctgcag aaaaaccccc cgacagagcc ctggcggaga ggcaggcgct ggggctccta     5220

cgggtccctg gggcagctgt ccccatcagg ccaagagcga gcgagaggcg ctgccccagc     5280

caggcccacc acctctcaca gtcagtgcac gcaagcaggg acatttccta gccagctggg     5340

ggacactgga aattcgggaa accaagagag aggaagaagg agacgcccct ccaactggcg     5400

ggtgtgaagg aagccgccca ggggtccggg ctgtccttgg ccgctggcag catcactgag     5460

caggaagcgc acagcccacc ctccccgcac ctccaggtct ctggactcca gttttggccc     5520

ctctcacaca gagctgtcag caggggccgc tgtggcggtg cacaggggag gcaggtcctt     5580

ggcgaggtag cccctgcctt aatccacggg gctcctttcc ctccgaaggg ctgctcttcc     5640

ccacaggcgc ggggacagca gcccgacctg tggtctccat gcctgtgccc tcacacaggt     5700

gtagcacacg catgtgcaga tggcaccacg gccggcacct gggggcacac acatgcaggc     5760

ggcgtggtct ccctgctctg tccccacacg ttcctcacat acaggcaaga ggcactgccg     5820

ggtcccggac ggctccgggt gacaccagcc ccgtctccag ccttgagccg cccatgctga     5880

tgcgacctcg gctgacagct gggcctgtgg tgcagacagg agctgtgtgg acagtcccgc     5940

ccaggagggg ccgcagggcg tgtatgagca gttttgcaaa cagaacacaa ccacaatgat     6000

ggtattttga aaagtgttct ttccgtgttc gtcgggaatc aggattattg agaggtgaag     6060

gagccaggtg gcttcattct ggcggtgaga ggcccacgac cacgggagtg agagctggtg     6120

tggcgaggcc cggctctcct gcggtgtggc tggtggcctg ccgtggccaa gagcatcttc     6180

tgggtggatg gaaccctgcc tggtcacatt tggccagaga cacacctggc cctcaggggg     6240

ctgagctgga gactgagctg gggctggccg ggacgtgaca aggcaggaca gaggcggccc     6300

ctccgctgct cctttttgga atgcgagctc ccaccagaag aaggttccgg cacgaatccc     6360

atccccacgt ctgggccgag aaagcagccc gggtccggaa ggtgtagaga gtcccggcct     6420

cactcagctc acagggcgtg ccaggcggca acaccagaat cttccagaag cccagctcca     6480

cccgcacacg cagcttccca tccagtcctt caactcaatt cttacccaac acgcgtttct     6540

gtttgttttg agacaaaatc accacctgtc aaaaggcagg tggctccaga ggggtcaaga     6600

cccccccccg cccccgctcc accctggagc ccacccccat gggcaccgcg tgccgcctgc     6660

acgtgggctg tcttcacagg tctgatgtga aaattcaatc acgacgttaa ccggctcgag     6720

agagcgccgg cctagaggct cattatctat ttattttacc aaacgcgaat tgagacggac     6780

tttgacaaaa cacgaaatgg taatgtgaag ctaagagcag agagtgacca acagtaaaca     6840

acacgcgcag actccg                                                     6856


<210>  28
<211>  1177
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Ser Glu Met Leu Gln Ser Pro Leu Leu Gly Leu Gly Glu Glu 
1               5                   10                  15      


Asp Glu Ala Asp Leu Thr Asp Trp Asn Leu Pro Leu Ala Phe Met Lys 
            20                  25                  30          


Lys Arg His Cys Glu Lys Ile Glu Gly Ser Lys Ser Leu Ala Gln Ser 
        35                  40                  45              


Trp Arg Met Lys Asp Arg Met Lys Thr Val Ser Val Ala Leu Val Leu 
    50                  55                  60                  


Cys Leu Asn Val Gly Val Asp Pro Pro Asp Val Val Lys Thr Thr Pro 
65                  70                  75                  80  


Cys Ala Arg Leu Glu Cys Trp Ile Asp Pro Leu Ser Met Gly Pro Gln 
                85                  90                  95      


Lys Ala Leu Glu Thr Ile Gly Ala Asn Leu Gln Lys Gln Tyr Glu Asn 
            100                 105                 110         


Trp Gln Pro Arg Ala Arg Tyr Lys Gln Ser Leu Asp Pro Thr Val Asp 
        115                 120                 125             


Glu Val Lys Lys Leu Cys Thr Ser Leu Arg Arg Asn Ala Lys Glu Glu 
    130                 135                 140                 


Arg Val Leu Phe His Tyr Asn Gly His Gly Val Pro Arg Pro Thr Val 
145                 150                 155                 160 


Asn Gly Glu Val Trp Val Phe Asn Lys Asn Tyr Thr Gln Tyr Ile Pro 
                165                 170                 175     


Leu Ser Ile Tyr Asp Leu Gln Thr Trp Met Gly Ser Pro Ser Ile Phe 
            180                 185                 190         


Val Tyr Asp Cys Ser Asn Ala Gly Leu Ile Val Lys Ser Phe Lys Gln 
        195                 200                 205             


Phe Ala Leu Gln Arg Glu Gln Glu Leu Glu Val Ala Ala Ile Asn Pro 
    210                 215                 220                 


Asn His Pro Leu Ala Gln Met Pro Leu Pro Pro Ser Met Lys Asn Cys 
225                 230                 235                 240 


Ile Gln Leu Ala Ala Cys Glu Ala Thr Glu Leu Leu Pro Met Ile Pro 
                245                 250                 255     


Asp Leu Pro Ala Asp Leu Phe Thr Ser Cys Leu Thr Thr Pro Ile Lys 
            260                 265                 270         


Ile Ala Leu Arg Trp Phe Cys Met Gln Lys Cys Val Ser Leu Val Pro 
        275                 280                 285             


Gly Val Thr Leu Asp Leu Ile Glu Lys Ile Pro Gly Arg Leu Asn Asp 
    290                 295                 300                 


Arg Arg Thr Pro Leu Gly Glu Leu Asn Trp Ile Phe Thr Ala Ile Thr 
305                 310                 315                 320 


Asp Thr Ile Ala Trp Asn Val Leu Pro Arg Asp Leu Phe Gln Lys Leu 
                325                 330                 335     


Phe Arg Gln Asp Leu Leu Val Ala Ser Leu Phe Arg Asn Phe Leu Leu 
            340                 345                 350         


Ala Glu Arg Ile Met Arg Ser Tyr Asn Cys Thr Pro Val Ser Ser Pro 
        355                 360                 365             


Arg Leu Pro Pro Thr Tyr Met His Ala Met Trp Gln Ala Trp Asp Leu 
    370                 375                 380                 


Ala Val Asp Ile Cys Leu Ser Gln Leu Pro Thr Ile Ile Glu Glu Gly 
385                 390                 395                 400 


Thr Ala Phe Arg His Ser Pro Phe Phe Ala Glu Gln Leu Thr Ala Phe 
                405                 410                 415     


Gln Val Trp Leu Thr Met Gly Val Glu Asn Arg Asn Pro Pro Glu Gln 
            420                 425                 430         


Leu Pro Ile Val Leu Gln Val Leu Leu Ser Gln Val His Arg Leu Arg 
        435                 440                 445             


Ala Leu Asp Leu Leu Gly Arg Phe Leu Asp Leu Gly Pro Trp Ala Val 
    450                 455                 460                 


Ser Leu Ala Leu Ser Val Gly Ile Phe Pro Tyr Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gln Ser Ser Ala Arg Glu Leu Arg Pro Leu Leu Val Phe Ile Trp Ala 
                485                 490                 495     


Lys Ile Leu Ala Val Asp Ser Glu Leu Val Val Ala Leu Ser His Leu 
            500                 505                 510         


Val Val Gln Tyr Glu Ser Asn Phe Cys Thr Val Ala Leu Gln Phe Ile 
        515                 520                 525             


Glu Glu Glu Lys Asn Tyr Ala Leu Pro Ser Pro Ala Thr Thr Glu Gly 
    530                 535                 540                 


Gly Ser Leu Thr Pro Val Arg Asp Ser Pro Cys Thr Pro Arg Leu Arg 
545                 550                 555                 560 


Ser Val Ser Ser Tyr Gly Asn Ile Arg Ala Val Ala Thr Ala Arg Ser 
                565                 570                 575     


Leu Asn Lys Ser Leu Gln Asn Leu Ser Leu Thr Glu Glu Ser Gly Gly 
            580                 585                 590         


Ala Val Ala Phe Ser Pro Gly Asn Leu Ser Thr Ser Ser Ser Ala Ser 
        595                 600                 605             


Ser Thr Leu Gly Ser Pro Glu Asn Glu Glu His Ile Leu Ser Phe Glu 
    610                 615                 620                 


Thr Ile Asp Lys Met Arg Arg Ala Ser Ser Tyr Ser Ser Leu Asn Ser 
625                 630                 635                 640 


Leu Ile Gly Val Ser Phe Asn Ser Val Tyr Thr Gln Ile Trp Arg Val 
                645                 650                 655     


Leu Leu His Leu Ala Ala Asp Pro Tyr Pro Glu Val Ser Asp Val Ala 
            660                 665                 670         


Met Lys Val Leu Asn Ser Ile Ala Tyr Lys Ala Thr Val Asn Ala Arg 
        675                 680                 685             


Pro Gln Arg Val Leu Asp Thr Ser Ser Leu Thr Gln Ser Ala Pro Ala 
    690                 695                 700                 


Ser Pro Thr Asn Lys Gly Val His Ile His Gln Ala Gly Gly Ser Pro 
705                 710                 715                 720 


Pro Ala Ser Ser Thr Ser Ser Ser Ser Leu Thr Asn Asp Val Ala Lys 
                725                 730                 735     


Gln Pro Val Ser Arg Asp Leu Pro Ser Gly Arg Pro Gly Thr Thr Gly 
            740                 745                 750         


Pro Ala Gly Ala Gln Tyr Thr Pro His Ser His Gln Phe Pro Arg Thr 
        755                 760                 765             


Arg Lys Met Phe Asp Lys Gly Pro Glu Gln Thr Ala Asp Asp Ala Asp 
    770                 775                 780                 


Asp Ala Ala Gly His Lys Ser Phe Ile Ser Ala Thr Val Gln Thr Gly 
785                 790                 795                 800 


Phe Cys Asp Trp Ser Ala Arg Tyr Phe Ala Gln Pro Val Met Lys Ile 
                805                 810                 815     


Pro Glu Glu His Asp Leu Glu Ser Gln Ile Arg Lys Glu Arg Glu Trp 
            820                 825                 830         


Arg Phe Leu Arg Asn Ser Arg Val Arg Arg Gln Ala Gln Gln Val Ile 
        835                 840                 845             


Gln Lys Gly Ile Thr Arg Leu Asp Asp Gln Ile Phe Leu Asn Arg Asn 
    850                 855                 860                 


Pro Gly Val Pro Ser Val Val Lys Phe His Pro Phe Thr Pro Cys Ile 
865                 870                 875                 880 


Ala Val Ala Asp Lys Asp Ser Ile Cys Phe Trp Asp Trp Glu Lys Gly 
                885                 890                 895     


Glu Lys Leu Asp Tyr Phe His Asn Gly Asn Pro Arg Tyr Thr Arg Val 
            900                 905                 910         


Thr Ala Met Glu Tyr Leu Asn Gly Gln Asp Cys Ser Leu Leu Leu Thr 
        915                 920                 925             


Ala Thr Asp Asp Gly Ala Ile Arg Val Trp Lys Asn Phe Ala Asp Leu 
    930                 935                 940                 


Glu Lys Asn Pro Glu Met Val Thr Ala Trp Gln Gly Leu Ser Asp Met 
945                 950                 955                 960 


Leu Pro Thr Thr Arg Gly Ala Gly Met Val Val Asp Trp Glu Gln Glu 
                965                 970                 975     


Thr Gly Leu Leu Met Ser Ser Gly Asp Val Arg Ile Val Arg Ile Trp 
            980                 985                 990         


Asp Thr Asp Arg Glu Met Lys Val  Gln Asp Ile Pro Thr  Gly Ala Asp 
        995                 1000                 1005             


Ser Cys  Val Thr Ser Leu Ser  Cys Asp Ser His Arg  Ser Leu Ile 
    1010                 1015                 1020             


Val Ala  Gly Leu Gly Asp Gly  Ser Ile Arg Val Tyr  Asp Arg Arg 
    1025                 1030                 1035             


Met Ala  Leu Ser Glu Cys Arg  Val Met Thr Tyr Arg  Glu His Thr 
    1040                 1045                 1050             


Ala Trp  Val Val Lys Ala Ser  Leu Gln Lys Arg Pro  Asp Gly His 
    1055                 1060                 1065             


Ile Val  Ser Val Ser Val Asn  Gly Asp Val Arg Ile  Phe Asp Pro 
    1070                 1075                 1080             


Arg Met  Pro Glu Ser Val Asn  Val Leu Gln Ile Val  Lys Gly Leu 
    1085                 1090                 1095             


Thr Ala  Leu Asp Ile His Pro  Gln Ala Asp Leu Ile  Ala Cys Gly 
    1100                 1105                 1110             


Ser Val  Asn Gln Phe Thr Ala  Ile Tyr Asn Ser Ser  Gly Glu Leu 
    1115                 1120                 1125             


Ile Asn  Asn Ile Lys Tyr Tyr  Asp Gly Phe Met Gly  Gln Arg Val 
    1130                 1135                 1140             


Gly Ala  Ile Ser Cys Leu Ala  Phe His Pro His Trp  Pro His Leu 
    1145                 1150                 1155             


Ala Val  Gly Ser Asn Asp Tyr  Tyr Ile Ser Val Tyr  Ser Val Glu 
    1160                 1165                 1170             


Lys Arg  Val Arg 
    1175         


<210>  29
<211>  1335
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Ser Glu Met Leu Gln Ser Pro Leu Leu Gly Leu Gly Glu Glu 
1               5                   10                  15      


Asp Glu Ala Asp Leu Thr Asp Trp Asn Leu Pro Leu Ala Phe Met Lys 
            20                  25                  30          


Lys Arg His Cys Glu Lys Ile Glu Gly Ser Lys Ser Leu Ala Gln Ser 
        35                  40                  45              


Trp Arg Met Lys Asp Arg Met Lys Thr Val Ser Val Ala Leu Val Leu 
    50                  55                  60                  


Cys Leu Asn Val Gly Val Asp Pro Pro Asp Val Val Lys Thr Thr Pro 
65                  70                  75                  80  


Cys Ala Arg Leu Glu Cys Trp Ile Asp Pro Leu Ser Met Gly Pro Gln 
                85                  90                  95      


Lys Ala Leu Glu Thr Ile Gly Ala Asn Leu Gln Lys Gln Tyr Glu Asn 
            100                 105                 110         


Trp Gln Pro Arg Ala Arg Tyr Lys Gln Ser Leu Asp Pro Thr Val Asp 
        115                 120                 125             


Glu Val Lys Lys Leu Cys Thr Ser Leu Arg Arg Asn Ala Lys Glu Glu 
    130                 135                 140                 


Arg Val Leu Phe His Tyr Asn Gly His Gly Val Pro Arg Pro Thr Val 
145                 150                 155                 160 


Asn Gly Glu Val Trp Val Phe Asn Lys Asn Tyr Thr Gln Tyr Ile Pro 
                165                 170                 175     


Leu Ser Ile Tyr Asp Leu Gln Thr Trp Met Gly Ser Pro Ser Ile Phe 
            180                 185                 190         


Val Tyr Asp Cys Ser Asn Ala Gly Leu Ile Val Lys Ser Phe Lys Gln 
        195                 200                 205             


Phe Ala Leu Gln Arg Glu Gln Glu Leu Glu Val Ala Ala Ile Asn Pro 
    210                 215                 220                 


Asn His Pro Leu Ala Gln Met Pro Leu Pro Pro Ser Met Lys Asn Cys 
225                 230                 235                 240 


Ile Gln Leu Ala Ala Cys Glu Ala Thr Glu Leu Leu Pro Met Ile Pro 
                245                 250                 255     


Asp Leu Pro Ala Asp Leu Phe Thr Ser Cys Leu Thr Thr Pro Ile Lys 
            260                 265                 270         


Ile Ala Leu Arg Trp Phe Cys Met Gln Lys Cys Val Ser Leu Val Pro 
        275                 280                 285             


Gly Val Thr Leu Asp Leu Ile Glu Lys Ile Pro Gly Arg Leu Asn Asp 
    290                 295                 300                 


Arg Arg Thr Pro Leu Gly Glu Leu Asn Trp Ile Phe Thr Ala Ile Thr 
305                 310                 315                 320 


Asp Thr Ile Ala Trp Asn Val Leu Pro Arg Asp Leu Phe Gln Lys Leu 
                325                 330                 335     


Phe Arg Gln Asp Leu Leu Val Ala Ser Leu Phe Arg Asn Phe Leu Leu 
            340                 345                 350         


Ala Glu Arg Ile Met Arg Ser Tyr Asn Cys Thr Pro Val Ser Ser Pro 
        355                 360                 365             


Arg Leu Pro Pro Thr Tyr Met His Ala Met Trp Gln Ala Trp Asp Leu 
    370                 375                 380                 


Ala Val Asp Ile Cys Leu Ser Gln Leu Pro Thr Ile Ile Glu Glu Gly 
385                 390                 395                 400 


Thr Ala Phe Arg His Ser Pro Phe Phe Ala Glu Gln Leu Thr Ala Phe 
                405                 410                 415     


Gln Val Trp Leu Thr Met Gly Val Glu Asn Arg Asn Pro Pro Glu Gln 
            420                 425                 430         


Leu Pro Ile Val Leu Gln Val Leu Leu Ser Gln Val His Arg Leu Arg 
        435                 440                 445             


Ala Leu Asp Leu Leu Gly Arg Phe Leu Asp Leu Gly Pro Trp Ala Val 
    450                 455                 460                 


Ser Leu Ala Leu Ser Val Gly Ile Phe Pro Tyr Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gln Ser Ser Ala Arg Glu Leu Arg Pro Leu Leu Val Phe Ile Trp Ala 
                485                 490                 495     


Lys Ile Leu Ala Val Asp Ser Ser Cys Gln Ala Asp Leu Val Lys Asp 
            500                 505                 510         


Asn Gly His Lys Tyr Phe Leu Ser Val Leu Ala Asp Pro Tyr Met Pro 
        515                 520                 525             


Ala Glu His Arg Thr Met Thr Ala Phe Ile Leu Ala Val Ile Val Asn 
    530                 535                 540                 


Ser Tyr His Thr Gly Gln Glu Ala Cys Leu Gln Gly Asn Leu Ile Ala 
545                 550                 555                 560 


Ile Cys Leu Glu Gln Leu Asn Asp Pro His Pro Leu Leu Arg Gln Trp 
                565                 570                 575     


Val Ala Ile Cys Leu Gly Arg Ile Trp Gln Asn Phe Asp Ser Ala Arg 
            580                 585                 590         


Trp Cys Gly Val Arg Asp Ser Ala His Glu Lys Leu Tyr Ser Leu Leu 
        595                 600                 605             


Ser Asp Pro Ile Pro Glu Val Arg Cys Ala Ala Val Phe Ala Leu Gly 
    610                 615                 620                 


Thr Phe Val Gly Asn Ser Ala Glu Arg Thr Asp His Ser Thr Thr Ile 
625                 630                 635                 640 


Asp His Asn Val Ala Met Met Leu Ala Gln Leu Val Ser Asp Gly Ser 
                645                 650                 655     


Pro Met Val Arg Lys Glu Leu Val Val Ala Leu Ser His Leu Val Val 
            660                 665                 670         


Gln Tyr Glu Ser Asn Phe Cys Thr Val Ala Leu Gln Phe Ile Glu Glu 
        675                 680                 685             


Glu Lys Asn Tyr Ala Leu Pro Ser Pro Ala Thr Thr Glu Gly Gly Ser 
    690                 695                 700                 


Leu Thr Pro Val Arg Asp Ser Pro Cys Thr Pro Arg Leu Arg Ser Val 
705                 710                 715                 720 


Ser Ser Tyr Gly Asn Ile Arg Ala Val Ala Thr Ala Arg Ser Leu Asn 
                725                 730                 735     


Lys Ser Leu Gln Asn Leu Ser Leu Thr Glu Glu Ser Gly Gly Ala Val 
            740                 745                 750         


Ala Phe Ser Pro Gly Asn Leu Ser Thr Ser Ser Ser Ala Ser Ser Thr 
        755                 760                 765             


Leu Gly Ser Pro Glu Asn Glu Glu His Ile Leu Ser Phe Glu Thr Ile 
    770                 775                 780                 


Asp Lys Met Arg Arg Ala Ser Ser Tyr Ser Ser Leu Asn Ser Leu Ile 
785                 790                 795                 800 


Gly Val Ser Phe Asn Ser Val Tyr Thr Gln Ile Trp Arg Val Leu Leu 
                805                 810                 815     


His Leu Ala Ala Asp Pro Tyr Pro Glu Val Ser Asp Val Ala Met Lys 
            820                 825                 830         


Val Leu Asn Ser Ile Ala Tyr Lys Ala Thr Val Asn Ala Arg Pro Gln 
        835                 840                 845             


Arg Val Leu Asp Thr Ser Ser Leu Thr Gln Ser Ala Pro Ala Ser Pro 
    850                 855                 860                 


Thr Asn Lys Gly Val His Ile His Gln Ala Gly Gly Ser Pro Pro Ala 
865                 870                 875                 880 


Ser Ser Thr Ser Ser Ser Ser Leu Thr Asn Asp Val Ala Lys Gln Pro 
                885                 890                 895     


Val Ser Arg Asp Leu Pro Ser Gly Arg Pro Gly Thr Thr Gly Pro Ala 
            900                 905                 910         


Gly Ala Gln Tyr Thr Pro His Ser His Gln Phe Pro Arg Thr Arg Lys 
        915                 920                 925             


Met Phe Asp Lys Gly Pro Glu Gln Thr Ala Asp Asp Ala Asp Asp Ala 
    930                 935                 940                 


Ala Gly His Lys Ser Phe Ile Ser Ala Thr Val Gln Thr Gly Phe Cys 
945                 950                 955                 960 


Asp Trp Ser Ala Arg Tyr Phe Ala Gln Pro Val Met Lys Ile Pro Glu 
                965                 970                 975     


Glu His Asp Leu Glu Ser Gln Ile Arg Lys Glu Arg Glu Trp Arg Phe 
            980                 985                 990         


Leu Arg Asn Ser Arg Val Arg Arg  Gln Ala Gln Gln Val  Ile Gln Lys 
        995                 1000                 1005             


Gly Ile  Thr Arg Leu Asp Asp  Gln Ile Phe Leu Asn  Arg Asn Pro 
    1010                 1015                 1020             


Gly Val  Pro Ser Val Val Lys  Phe His Pro Phe Thr  Pro Cys Ile 
    1025                 1030                 1035             


Ala Val  Ala Asp Lys Asp Ser  Ile Cys Phe Trp Asp  Trp Glu Lys 
    1040                 1045                 1050             


Gly Glu  Lys Leu Asp Tyr Phe  His Asn Gly Asn Pro  Arg Tyr Thr 
    1055                 1060                 1065             


Arg Val  Thr Ala Met Glu Tyr  Leu Asn Gly Gln Asp  Cys Ser Leu 
    1070                 1075                 1080             


Leu Leu  Thr Ala Thr Asp Asp  Gly Ala Ile Arg Val  Trp Lys Asn 
    1085                 1090                 1095             


Phe Ala  Asp Leu Glu Lys Asn  Pro Glu Met Val Thr  Ala Trp Gln 
    1100                 1105                 1110             


Gly Leu  Ser Asp Met Leu Pro  Thr Thr Arg Gly Ala  Gly Met Val 
    1115                 1120                 1125             


Val Asp  Trp Glu Gln Glu Thr  Gly Leu Leu Met Ser  Ser Gly Asp 
    1130                 1135                 1140             


Val Arg  Ile Val Arg Ile Trp  Asp Thr Asp Arg Glu  Met Lys Val 
    1145                 1150                 1155             


Gln Asp  Ile Pro Thr Gly Ala  Asp Ser Cys Val Thr  Ser Leu Ser 
    1160                 1165                 1170             


Cys Asp  Ser His Arg Ser Leu  Ile Val Ala Gly Leu  Gly Asp Gly 
    1175                 1180                 1185             


Ser Ile  Arg Val Tyr Asp Arg  Arg Met Ala Leu Ser  Glu Cys Arg 
    1190                 1195                 1200             


Val Met  Thr Tyr Arg Glu His  Thr Ala Trp Val Val  Lys Ala Ser 
    1205                 1210                 1215             


Leu Gln  Lys Arg Pro Asp Gly  His Ile Val Ser Val  Ser Val Asn 
    1220                 1225                 1230             


Gly Asp  Val Arg Ile Phe Asp  Pro Arg Met Pro Glu  Ser Val Asn 
    1235                 1240                 1245             


Val Leu  Gln Ile Val Lys Gly  Leu Thr Ala Leu Asp  Ile His Pro 
    1250                 1255                 1260             


Gln Ala  Asp Leu Ile Ala Cys  Gly Ser Val Asn Gln  Phe Thr Ala 
    1265                 1270                 1275             


Ile Tyr  Asn Ser Ser Gly Glu  Leu Ile Asn Asn Ile  Lys Tyr Tyr 
    1280                 1285                 1290             


Asp Gly  Phe Met Gly Gln Arg  Val Gly Ala Ile Ser  Cys Leu Ala 
    1295                 1300                 1305             


Phe His  Pro His Trp Pro His  Leu Ala Val Gly Ser  Asn Asp Tyr 
    1310                 1315                 1320             


Tyr Ile  Ser Val Tyr Ser Val  Glu Lys Arg Val Arg  
    1325                 1330                 1335 


<210>  30
<211>  1555
<212>  DNA
<213>  Homo sapiens

<400>  30
atcccggaag gaccggtgtc taggtcaccc tggagcgctc accccaccgg cacccgtgcc       60

caagcccgcc cctgcaaagg caggcaaggc caggcgggtg ctgcctggga cccagtgact      120

cagcacccct gcccggatca actggacttt tgccccctgc tccgccagcc tcctgcttgg      180

atctctcctg ggtctccctg ctgcgcctgt ccaggatgca gggagctcgg gctcccaggg      240

accagggccg gtcccccggc aggatgagcg ctctaggccg gtcctcggtc atcttgctta      300

cctacgtgct ggccgccaca gaacttacct gcctcttcat gcagttctcc atcgtgccat      360

acctgtctcg gaaactgggc ctggattcca ttgccttcgg ctacctgcaa accaccttcg      420

gggtgctgca gctgctgggc gggccggtat ttggcaggtt cgcagaccag cgcggggcgc      480

gggcggcgct cacgctctcc ttcctggctg ccttggcgct ctacctgctc ctggcggccg      540

cctccagccc ggccctgccc ggggtctacc tgctcttcgc ctcgcgcctg cccggagcgc      600

tcatgcacac gctgccagcc gcccagatgg tcatcacgga cctgtcggca cccgaggagc      660

ggcccgcggc cctgggccgg ctgggcctct gcttcggcgt cggagtcatc ctcggctccc      720

tgctgggcgg gaccctggtc tccgcgtacg ggattcagtg cccggccatc ctggctgccc      780

tggccaccct cctgggagct gtcctcagct tcacctgcat ccccgccagc accaaagggg      840

ccaaaactga cgcccaggct ccactgccag gcggcccccg ggccagtgtg ttcgacctga      900

aggccatcgc ctccctgctg cggctgccag acgtcccgag gatcttcctg gtgaaggtgg      960

cctccaactg ccccacaggg ctcttcatgg tcatgttctc catcatctcc atggacttct     1020

tccagctgga ggccgcccaa gctggctacc tcatgtcctt cttcgggctc ctccagatgg     1080

tgacccaggg cctggtcatc gggcagctga gcagccactt ctcggaggag gtgctgctcc     1140

gggccagcgt gctggtcttc atcgtggtgg gcctggccat ggcctggatg tccagcgtct     1200

tccacttctg cctcctggtg cccggcctgg tgttcagcct ctgcaccctc aacgtggtca     1260

ccgacagcat gctgatcaag gctgtctcca cctcggacac agggaccatg ctgggcctct     1320

gcgcctctgt acaaccactg ctccgaactc tgggacccac ggtcggcggc ctcctgtacc     1380

gcagctttgg cgtccccgtc ttcggccacg tgcaggttgc tatcaatacc cttgtcctcc     1440

tggtcctctg gaggaaacct atgccccaga ggaaggacaa agtccggtga ccgctgccca     1500

gacacagact ggcaataaac tcctactaaa tccctccgaa aaaaaaaaaa aaaaa          1555


<210>  31
<211>  1563
<212>  DNA
<213>  Homo sapiens

<400>  31
gacaaaaaaa aaggtctctc cgatttcctc tgctcaacca gttccctggc tacctgaggc       60

cctgcttcac ctggaggaag acagtggcaa ggccaggcgg gtgctgcctg ggacccagtg      120

actcagcacc cctgcccgga tcaactggac ttttgccccc tgctccgcca gcctcctgct      180

tggatctctc ctgggtctcc ctgctgcgcc tgtccaggat gcagggagct cgggctccca      240

gggaccaggg ccggtccccc ggcaggatga gcgctctagg ccggtcctcg gtcatcttgc      300

ttacctacgt gctggccgcc acagaactta cctgcctctt catgcagttc tccatcgtgc      360

catacctgtc tcggaaactg ggcctggatt ccattgcctt cggctacctg caaaccacct      420

tcggggtgct gcagctgctg ggcgggccgg tatttggcag gttcgcagac cagcgcgggg      480

cgcgggcggc gctcacgctc tccttcctgg ctgccttggc gctctacctg ctcctggcgg      540

ccgcctccag cccggccctg cccggggtct acctgctctt cgcctcgcgc ctgcccggag      600

cgctcatgca cacgctgcca gccgcccaga tggtcatcac ggacctgtcg gcacccgagg      660

agcggcccgc ggccctgggc cggctgggcc tctgcttcgg cgtcggagtc atcctcggct      720

ccctgctggg cgggaccctg gtctccgcgt acgggattca gtgcccggcc atcctggctg      780

ccctggccac cctcctggga gctgtcctca gcttcacctg catccccgcc agcaccaaag      840

gggccaaaac tgacgcccag gctccactgc caggcggccc ccgggccagt gtgttcgacc      900

tgaaggccat cgcctccctg ctgcggctgc cagacgtccc gaggatcttc ctggtgaagg      960

tggcctccaa ctgccccaca gggctcttca tggtcatgtt ctccatcatc tccatggact     1020

tcttccagct ggaggccgcc caagctggct acctcatgtc cttcttcggg ctcctccaga     1080

tggtgaccca gggcctggtc atcgggcagc tgagcagcca cttctcggag gaggtgctgc     1140

tccgggccag cgtgctggtc ttcatcgtgg tgggcctggc catggcctgg atgtccagcg     1200

tcttccactt ctgcctcctg gtgcccggcc tggtgttcag cctctgcacc ctcaacgtgg     1260

tcaccgacag catgctgatc aaggctgtct ccacctcgga cacagggacc atgctgggcc     1320

tctgcgcctc tgtacaacca ctgctccgaa ctctgggacc cacggtcggc ggcctcctgt     1380

accgcagctt tggcgtcccc gtcttcggcc acgtgcaggt tgctatcaat acccttgtcc     1440

tcctggtcct ctggaggaaa cctatgcccc agaggaagga caaagtccgg tgaccgctgc     1500

ccagacacag actggcaata aactcctact aaatccctcc gaaaaaaaaa aaaaaaaaaa     1560

aaa                                                                   1563


<210>  32
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gln Gly Ala Arg Ala Pro Arg Asp Gln Gly Arg Ser Pro Gly Arg 
1               5                   10                  15      


Met Ser Ala Leu Gly Arg Ser Ser Val Ile Leu Leu Thr Tyr Val Leu 
            20                  25                  30          


Ala Ala Thr Glu Leu Thr Cys Leu Phe Met Gln Phe Ser Ile Val Pro 
        35                  40                  45              


Tyr Leu Ser Arg Lys Leu Gly Leu Asp Ser Ile Ala Phe Gly Tyr Leu 
    50                  55                  60                  


Gln Thr Thr Phe Gly Val Leu Gln Leu Leu Gly Gly Pro Val Phe Gly 
65                  70                  75                  80  


Arg Phe Ala Asp Gln Arg Gly Ala Arg Ala Ala Leu Thr Leu Ser Phe 
                85                  90                  95      


Leu Ala Ala Leu Ala Leu Tyr Leu Leu Leu Ala Ala Ala Ser Ser Pro 
            100                 105                 110         


Ala Leu Pro Gly Val Tyr Leu Leu Phe Ala Ser Arg Leu Pro Gly Ala 
        115                 120                 125             


Leu Met His Thr Leu Pro Ala Ala Gln Met Val Ile Thr Asp Leu Ser 
    130                 135                 140                 


Ala Pro Glu Glu Arg Pro Ala Ala Leu Gly Arg Leu Gly Leu Cys Phe 
145                 150                 155                 160 


Gly Val Gly Val Ile Leu Gly Ser Leu Leu Gly Gly Thr Leu Val Ser 
                165                 170                 175     


Ala Tyr Gly Ile Gln Cys Pro Ala Ile Leu Ala Ala Leu Ala Thr Leu 
            180                 185                 190         


Leu Gly Ala Val Leu Ser Phe Thr Cys Ile Pro Ala Ser Thr Lys Gly 
        195                 200                 205             


Ala Lys Thr Asp Ala Gln Ala Pro Leu Pro Gly Gly Pro Arg Ala Ser 
    210                 215                 220                 


Val Phe Asp Leu Lys Ala Ile Ala Ser Leu Leu Arg Leu Pro Asp Val 
225                 230                 235                 240 


Pro Arg Ile Phe Leu Val Lys Val Ala Ser Asn Cys Pro Thr Gly Leu 
                245                 250                 255     


Phe Met Val Met Phe Ser Ile Ile Ser Met Asp Phe Phe Gln Leu Glu 
            260                 265                 270         


Ala Ala Gln Ala Gly Tyr Leu Met Ser Phe Phe Gly Leu Leu Gln Met 
        275                 280                 285             


Val Thr Gln Gly Leu Val Ile Gly Gln Leu Ser Ser His Phe Ser Glu 
    290                 295                 300                 


Glu Val Leu Leu Arg Ala Ser Val Leu Val Phe Ile Val Val Gly Leu 
305                 310                 315                 320 


Ala Met Ala Trp Met Ser Ser Val Phe His Phe Cys Leu Leu Val Pro 
                325                 330                 335     


Gly Leu Val Phe Ser Leu Cys Thr Leu Asn Val Val Thr Asp Ser Met 
            340                 345                 350         


Leu Ile Lys Ala Val Ser Thr Ser Asp Thr Gly Thr Met Leu Gly Leu 
        355                 360                 365             


Cys Ala Ser Val Gln Pro Leu Leu Arg Thr Leu Gly Pro Thr Val Gly 
    370                 375                 380                 


Gly Leu Leu Tyr Arg Ser Phe Gly Val Pro Val Phe Gly His Val Gln 
385                 390                 395                 400 


Val Ala Ile Asn Thr Leu Val Leu Leu Val Leu Trp Arg Lys Pro Met 
                405                 410                 415     


Pro Gln Arg Lys Asp Lys Val Arg 
            420                 


<210>  33
<211>  1335
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Glu Ser Glu Met Leu Gln Ser Pro Leu Leu Gly Leu Gly Glu Glu 
1               5                   10                  15      


Asp Glu Ala Asp Leu Thr Asp Trp Asn Leu Pro Leu Ala Phe Met Lys 
            20                  25                  30          


Lys Arg His Cys Glu Lys Ile Glu Gly Ser Lys Ser Leu Ala Gln Ser 
        35                  40                  45              


Trp Arg Met Lys Asp Arg Met Lys Thr Val Ser Val Ala Leu Val Leu 
    50                  55                  60                  


Cys Leu Asn Val Gly Val Asp Pro Pro Asp Val Val Lys Thr Thr Pro 
65                  70                  75                  80  


Cys Ala Arg Leu Glu Cys Trp Ile Asp Pro Leu Ser Met Gly Pro Gln 
                85                  90                  95      


Lys Ala Leu Glu Thr Ile Gly Ala Asn Leu Gln Lys Gln Tyr Glu Asn 
            100                 105                 110         


Trp Gln Pro Arg Ala Arg Tyr Lys Gln Ser Leu Asp Pro Thr Val Asp 
        115                 120                 125             


Glu Val Lys Lys Leu Cys Thr Ser Leu Arg Arg Asn Ala Lys Glu Glu 
    130                 135                 140                 


Arg Val Leu Phe His Tyr Asn Gly His Gly Val Pro Arg Pro Thr Val 
145                 150                 155                 160 


Asn Gly Glu Val Trp Val Phe Asn Lys Asn Tyr Thr Gln Tyr Ile Pro 
                165                 170                 175     


Leu Ser Ile Tyr Asp Leu Gln Thr Trp Met Gly Ser Pro Ser Ile Phe 
            180                 185                 190         


Val Tyr Asp Cys Ser Asn Ala Gly Leu Ile Val Lys Ser Phe Lys Gln 
        195                 200                 205             


Phe Ala Leu Gln Arg Glu Gln Glu Leu Glu Val Ala Ala Ile Asn Pro 
    210                 215                 220                 


Asn His Pro Leu Ala Gln Met Pro Leu Pro Pro Ser Met Lys Asn Cys 
225                 230                 235                 240 


Ile Gln Leu Ala Ala Cys Glu Ala Thr Glu Leu Leu Pro Met Ile Pro 
                245                 250                 255     


Asp Leu Pro Ala Asp Leu Phe Thr Ser Cys Leu Thr Thr Pro Ile Lys 
            260                 265                 270         


Ile Ala Leu Arg Trp Phe Cys Met Gln Lys Cys Val Ser Leu Val Pro 
        275                 280                 285             


Gly Val Thr Leu Asp Leu Ile Glu Lys Ile Pro Gly Arg Leu Asn Asp 
    290                 295                 300                 


Arg Arg Thr Pro Leu Gly Glu Leu Asn Trp Ile Phe Thr Ala Ile Thr 
305                 310                 315                 320 


Asp Thr Ile Ala Trp Asn Val Leu Pro Arg Asp Leu Phe Gln Lys Leu 
                325                 330                 335     


Phe Arg Gln Asp Leu Leu Val Ala Ser Leu Phe Arg Asn Phe Leu Leu 
            340                 345                 350         


Ala Glu Arg Ile Met Arg Ser Tyr Asn Cys Thr Pro Val Ser Ser Pro 
        355                 360                 365             


Arg Leu Pro Pro Thr Tyr Met His Ala Met Trp Gln Ala Trp Asp Leu 
    370                 375                 380                 


Ala Val Asp Ile Cys Leu Ser Gln Leu Pro Thr Ile Ile Glu Glu Gly 
385                 390                 395                 400 


Thr Ala Phe Arg His Ser Pro Phe Phe Ala Glu Gln Leu Thr Ala Phe 
                405                 410                 415     


Gln Val Trp Leu Thr Met Gly Val Glu Asn Arg Asn Pro Pro Glu Gln 
            420                 425                 430         


Leu Pro Ile Val Leu Gln Val Leu Leu Ser Gln Val His Arg Leu Arg 
        435                 440                 445             


Ala Leu Asp Leu Leu Gly Arg Phe Leu Asp Leu Gly Pro Trp Ala Val 
    450                 455                 460                 


Ser Leu Ala Leu Ser Val Gly Ile Phe Pro Tyr Val Leu Lys Leu Leu 
465                 470                 475                 480 


Gln Ser Ser Ala Arg Glu Leu Arg Pro Leu Leu Val Phe Ile Trp Ala 
                485                 490                 495     


Lys Ile Leu Ala Val Asp Ser Ser Cys Gln Ala Asp Leu Val Lys Asp 
            500                 505                 510         


Asn Gly His Lys Tyr Phe Leu Ser Val Leu Ala Asp Pro Tyr Met Pro 
        515                 520                 525             


Ala Glu His Arg Thr Met Thr Ala Phe Ile Leu Ala Val Ile Val Asn 
    530                 535                 540                 


Ser Tyr His Thr Gly Gln Glu Ala Cys Leu Gln Gly Asn Leu Ile Ala 
545                 550                 555                 560 


Ile Cys Leu Glu Gln Leu Asn Asp Pro His Pro Leu Leu Arg Gln Trp 
                565                 570                 575     


Val Ala Ile Cys Leu Gly Arg Ile Trp Gln Asn Phe Asp Ser Ala Arg 
            580                 585                 590         


Trp Cys Gly Val Arg Asp Ser Ala His Glu Lys Leu Tyr Ser Leu Leu 
        595                 600                 605             


Ser Asp Pro Ile Pro Glu Val Arg Cys Ala Ala Val Phe Ala Leu Gly 
    610                 615                 620                 


Thr Phe Val Gly Asn Ser Ala Glu Arg Thr Asp His Ser Thr Thr Ile 
625                 630                 635                 640 


Asp His Asn Val Ala Met Met Leu Ala Gln Leu Val Ser Asp Gly Ser 
                645                 650                 655     


Pro Met Val Arg Lys Glu Leu Val Val Ala Leu Ser His Leu Val Val 
            660                 665                 670         


Gln Tyr Glu Ser Asn Phe Cys Thr Val Ala Leu Gln Phe Ile Glu Glu 
        675                 680                 685             


Glu Lys Asn Tyr Ala Leu Pro Ser Pro Ala Thr Thr Glu Gly Gly Ser 
    690                 695                 700                 


Leu Thr Pro Val Arg Asp Ser Pro Cys Thr Pro Arg Leu Arg Ser Val 
705                 710                 715                 720 


Ser Ser Tyr Gly Asn Ile Arg Ala Val Ala Thr Ala Arg Ser Leu Asn 
                725                 730                 735     


Lys Ser Leu Gln Asn Leu Ser Leu Thr Glu Glu Ser Gly Gly Ala Val 
            740                 745                 750         


Ala Phe Ser Pro Gly Asn Leu Ser Thr Ser Ser Ser Ala Ser Ser Thr 
        755                 760                 765             


Leu Gly Ser Pro Glu Asn Glu Glu His Ile Leu Ser Phe Glu Thr Ile 
    770                 775                 780                 


Asp Lys Met Arg Arg Ala Ser Ser Tyr Ser Ser Leu Asn Ser Leu Ile 
785                 790                 795                 800 


Gly Val Ser Phe Asn Ser Val Tyr Thr Gln Ile Trp Arg Val Leu Leu 
                805                 810                 815     


His Leu Ala Ala Asp Pro Tyr Pro Glu Val Ser Asp Val Ala Met Lys 
            820                 825                 830         


Val Leu Asn Ser Ile Ala Tyr Lys Ala Thr Val Asn Ala Arg Pro Gln 
        835                 840                 845             


Arg Val Leu Asp Thr Ser Ser Leu Thr Gln Ser Ala Pro Ala Ser Pro 
    850                 855                 860                 


Thr Asn Lys Gly Val His Ile His Gln Ala Gly Gly Ser Pro Pro Ala 
865                 870                 875                 880 


Ser Ser Thr Ser Ser Ser Ser Leu Thr Asn Asp Val Ala Lys Gln Pro 
                885                 890                 895     


Val Ser Arg Asp Leu Pro Ser Gly Arg Pro Gly Thr Thr Gly Pro Ala 
            900                 905                 910         


Gly Ala Gln Tyr Thr Pro His Ser His Gln Phe Pro Arg Thr Arg Lys 
        915                 920                 925             


Met Phe Asp Lys Gly Pro Glu Gln Thr Ala Asp Asp Ala Asp Asp Ala 
    930                 935                 940                 


Ala Gly His Lys Ser Phe Ile Ser Ala Thr Val Gln Thr Gly Phe Cys 
945                 950                 955                 960 


Asp Trp Ser Ala Arg Tyr Phe Ala Gln Pro Val Met Lys Ile Pro Glu 
                965                 970                 975     


Glu His Asp Leu Glu Ser Gln Ile Arg Lys Glu Arg Glu Trp Arg Phe 
            980                 985                 990         


Leu Arg Asn Ser Arg Val Arg Arg  Gln Ala Gln Gln Val  Ile Gln Lys 
        995                 1000                 1005             


Gly Ile  Thr Arg Leu Asp Asp  Gln Ile Phe Leu Asn  Arg Asn Pro 
    1010                 1015                 1020             


Gly Val  Pro Ser Val Val Lys  Phe His Pro Phe Thr  Pro Cys Ile 
    1025                 1030                 1035             


Ala Val  Ala Asp Lys Asp Ser  Ile Cys Phe Trp Asp  Trp Glu Lys 
    1040                 1045                 1050             


Gly Glu  Lys Leu Asp Tyr Phe  His Asn Gly Asn Pro  Arg Tyr Thr 
    1055                 1060                 1065             


Arg Val  Thr Ala Met Glu Tyr  Leu Asn Gly Gln Asp  Cys Ser Leu 
    1070                 1075                 1080             


Leu Leu  Thr Ala Thr Asp Asp  Gly Ala Ile Arg Val  Trp Lys Asn 
    1085                 1090                 1095             


Phe Ala  Asp Leu Glu Lys Asn  Pro Glu Met Val Thr  Ala Trp Gln 
    1100                 1105                 1110             


Gly Leu  Ser Asp Met Leu Pro  Thr Thr Arg Gly Ala  Gly Met Val 
    1115                 1120                 1125             


Val Asp  Trp Glu Gln Glu Thr  Gly Leu Leu Met Ser  Ser Gly Asp 
    1130                 1135                 1140             


Val Arg  Ile Val Arg Ile Trp  Asp Thr Asp Arg Glu  Met Lys Val 
    1145                 1150                 1155             


Gln Asp  Ile Pro Thr Gly Ala  Asp Ser Cys Val Thr  Ser Leu Ser 
    1160                 1165                 1170             


Cys Asp  Ser His Arg Ser Leu  Ile Val Ala Gly Leu  Gly Asp Gly 
    1175                 1180                 1185             


Ser Ile  Arg Val Tyr Asp Arg  Arg Met Ala Leu Ser  Glu Cys Arg 
    1190                 1195                 1200             


Val Met  Thr Tyr Arg Glu His  Thr Ala Trp Val Val  Lys Ala Ser 
    1205                 1210                 1215             


Leu Gln  Lys Arg Pro Asp Gly  His Ile Val Ser Val  Ser Val Asn 
    1220                 1225                 1230             


Gly Asp  Val Arg Ile Phe Asp  Pro Arg Met Pro Glu  Ser Val Asn 
    1235                 1240                 1245             


Val Leu  Gln Ile Val Lys Gly  Leu Thr Ala Leu Asp  Ile His Pro 
    1250                 1255                 1260             


Gln Ala  Asp Leu Ile Ala Cys  Gly Ser Val Asn Gln  Phe Thr Ala 
    1265                 1270                 1275             


Ile Tyr  Asn Ser Ser Gly Glu  Leu Ile Asn Asn Ile  Lys Tyr Tyr 
    1280                 1285                 1290             


Asp Gly  Phe Met Gly Gln Arg  Val Gly Ala Ile Ser  Cys Leu Ala 
    1295                 1300                 1305             


Phe His  Pro His Trp Pro His  Leu Ala Val Gly Ser  Asn Asp Tyr 
    1310                 1315                 1320             


Tyr Ile  Ser Val Tyr Ser Val  Glu Lys Arg Val Arg  
    1325                 1330                 1335 


<210>  34
<211>  2428
<212>  DNA
<213>  Homo sapiens

<400>  34
ctgggcccag cctatagtca gcggtgtcta tgggcatgga tctggacggg gaaaaggaca       60

aagcagcctc catccacagt tcattccggg accaggccct tgcaggcacg cgctgggctc      120

ctgtgggaag acactaaggg ccccaggaca gacctcctct ccgggcatct gggttcctag      180

atggcagagg tggcagagtg gggtgggatg gcccaattgg gagctttagc ttccggcaaa      240

gagctgagca cagtacatct tcaatgtgta agattctcct gggagaccag ggcccagctg      300

gtggtgagct gggggaagtg ggtgatactg ccgtgggagg agccacctgg ccctctgggg      360

aagtgcactc gctgtctgca gcgcccaggc ctgggtagct gggtgggggc tggggggcca      420

tctgtgctca gggtgcctgc acctgggcct tctctgccct gggccaagcc tgcccgagcc      480

tctctgtcct ctgcctgccc agctggacat ctctgggcct ctctggagac cagtggggtg      540

ggctgtgggg gcgtcatatt gccctggctt ggcatccctc ttgtggctgt acccctccca      600

gcagccccag gactagcaag tccccgagat gggggtgggg acagtggttg atgccaaagg      660

ttgtgggggc aggggcgggg caggagcagg aaggtcccct gagttccctc accttgggca      720

gagataaaag gagcacagtt ccaggcgggg ctgagctagg gcgtagctgt gatttcaggg      780

gcacctctgg cggctgccgt gatttgagaa tctcgggtct cttggctgac tgatcctggg      840

agactgtgga tgaataatgc tgggcacggc cccacccgga ggctgcgagg cttgggggtc      900

ctggccgggg tggctctgct cgctgccctc tggctcctgt ggctgctggg gtcagcccct      960

cggggtaccc cggcacccca gcccacgatc accatccttg tctggcactg gcccttcact     1020

gaccagcccc cagagctgcc cagcgacacc tgcacccgct acggcatcgc ccgctgccac     1080

ctgagtgcca accgaagcct gctggccagc gccgacgccg tggtcttcca ccaccgcgag     1140

ctgcagaccc ggcggtccca cctgcccctg gcccagcggc cgcgagggca gccctgggtg     1200

tgggcctcca tggagtctcc tagccacacc cacggcctca gccacctccg aggcatcttc     1260

aactgggtgc tgagctaccg gcgcgactcg gacatctttg tgccctatgg ccgcctggag     1320

ccccactggg ggccctcgcc accgctgcca gccaagagca gggtggccgc ctgggtggtc     1380

agcaacttcc aggagcggca gctgcgtgcc aggctgtacc ggcagctggc gcctcatctg     1440

cgggtggatg tctttggccg tgccaatgga cggccactgt gcgccagctg cctggtgccc     1500

accgtggccc agtaccgctt ctacctgtcc tttgagaact ctcagcaccg cgactacatt     1560

acggagaaat tctggcgcaa cgcactggtg gctggcactg tgccagtggt gctggggccc     1620

ccacgggcca cctatgaggc cttcgtgccg gctgacgcct tcgtgcatgt ggatgacttt     1680

ggctcagccc gagagctggc ggctttcctc actggcatga atgagagccg ataccaacgc     1740

ttctttgcct ggcgtgacag gctccgcgtg cgactgttca ccgactggcg ggaacgtttc     1800

tgtgccatct gtgaccgcta cccacaccta ccccgcagcc aagtctatga ggaccttgag     1860

ggttggtttc aggcctgaga tccgctggcc gggggaggtg ggtgtgggtg gaagggctgg     1920

gtgtcgaaat caaaccacca ggcatccggc ccttaccggc aagcagcggg ctaacgggag     1980

gctgggcaca gaggtcagga agcaggggtg gggggtgcag gtgggcactg gagcatgcag     2040

aggaggtgag agtgggaggg aggtaacggg tgcctgctgc ggcagacggg aggggaaagg     2100

ctgccgagga ccctccccac cctgaacaaa tcttgggtgg gtgaaggcct ggctggaaga     2160

gggtgaaagg cagggccctt ggggctgggg ggcaccccag cctgaagttt gtgggggcca     2220

aacctgggac cccgagcttc ctcggtagca gaggccctgt ggtccccgag acacaggcac     2280

gggtccctgc cacgtccata gttctgaggt ccctgtgtgt aggctggggc ggggcccagg     2340

agaccacggg gagcaaacca gcttgttctg ggctcaggga gggagggcgg tggacaataa     2400

acatctgagc agtgaaaaaa aaaaaaaa                                        2428


<210>  35
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asn Asn Ala Gly His Gly Pro Thr Arg Arg Leu Arg Gly Leu Gly 
1               5                   10                  15      


Val Leu Ala Gly Val Ala Leu Leu Ala Ala Leu Trp Leu Leu Trp Leu 
            20                  25                  30          


Leu Gly Ser Ala Pro Arg Gly Thr Pro Ala Pro Gln Pro Thr Ile Thr 
        35                  40                  45              


Ile Leu Val Trp His Trp Pro Phe Thr Asp Gln Pro Pro Glu Leu Pro 
    50                  55                  60                  


Ser Asp Thr Cys Thr Arg Tyr Gly Ile Ala Arg Cys His Leu Ser Ala 
65                  70                  75                  80  


Asn Arg Ser Leu Leu Ala Ser Ala Asp Ala Val Val Phe His His Arg 
                85                  90                  95      


Glu Leu Gln Thr Arg Arg Ser His Leu Pro Leu Ala Gln Arg Pro Arg 
            100                 105                 110         


Gly Gln Pro Trp Val Trp Ala Ser Met Glu Ser Pro Ser His Thr His 
        115                 120                 125             


Gly Leu Ser His Leu Arg Gly Ile Phe Asn Trp Val Leu Ser Tyr Arg 
    130                 135                 140                 


Arg Asp Ser Asp Ile Phe Val Pro Tyr Gly Arg Leu Glu Pro His Trp 
145                 150                 155                 160 


Gly Pro Ser Pro Pro Leu Pro Ala Lys Ser Arg Val Ala Ala Trp Val 
                165                 170                 175     


Val Ser Asn Phe Gln Glu Arg Gln Leu Arg Ala Arg Leu Tyr Arg Gln 
            180                 185                 190         


Leu Ala Pro His Leu Arg Val Asp Val Phe Gly Arg Ala Asn Gly Arg 
        195                 200                 205             


Pro Leu Cys Ala Ser Cys Leu Val Pro Thr Val Ala Gln Tyr Arg Phe 
    210                 215                 220                 


Tyr Leu Ser Phe Glu Asn Ser Gln His Arg Asp Tyr Ile Thr Glu Lys 
225                 230                 235                 240 


Phe Trp Arg Asn Ala Leu Val Ala Gly Thr Val Pro Val Val Leu Gly 
                245                 250                 255     


Pro Pro Arg Ala Thr Tyr Glu Ala Phe Val Pro Ala Asp Ala Phe Val 
            260                 265                 270         


His Val Asp Asp Phe Gly Ser Ala Arg Glu Leu Ala Ala Phe Leu Thr 
        275                 280                 285             


Gly Met Asn Glu Ser Arg Tyr Gln Arg Phe Phe Ala Trp Arg Asp Arg 
    290                 295                 300                 


Leu Arg Val Arg Leu Phe Thr Asp Trp Arg Glu Arg Phe Cys Ala Ile 
305                 310                 315                 320 


Cys Asp Arg Tyr Pro His Leu Pro Arg Ser Gln Val Tyr Glu Asp Leu 
                325                 330                 335     


Glu Gly Trp Phe Gln Ala 
            340         


<210>  36
<211>  1671
<212>  DNA
<213>  Homo sapiens

<400>  36
cccaactggc agcgacagct gcagacgggc tgaaccagct ttgttcccag ggtggcgcct       60

gctctccatc caggccccat tccggctccc acccgacgct gcttttgttc ccacgtttcg      120

gggggcagct ggcactgtga ttcctgcccc atgagtgcct agaggcacgg agccaccagg      180

gatcacccca cgtgggacac agggcttggg gaggatgggg caggaccaga ccaagcagca      240

gatcgagaag gggctccagc tgtaccagtc caaccagaca gagaaggcat tgcaggtgtg      300

gacaaaggtg ctggagaaga gctcggacct catggggcgc ttccgcgtgc tgggctgcct      360

ggtcacagcc cactcggaga tgggccgcta caaggagatg ctgaagttcg ctgtggtcca      420

gatcgacacg gcccgggagc tggaggatgc cgacttcctc ctggagagct acctgaacct      480

ggcacgcagc aacgagaagc tgtgcgagtt tcacaagacc atctcctact gcaagacctg      540

ccttgggctg cctggtacca gggcaggtgc ccagctcgga ggccaggtca gcctgagcat      600

gggcaatgcc ttcctgggcc tcagcgtctt ccagaaggcc ctggagagct tcgagaaggc      660

cctgcgctat gcccacaaca atgatgacgc catgctcgag tgccgcgtgt gctgcagcct      720

gggcagcttc tatgcccagg tcaaggacta cgagaaagcc ctgttcttcc cctgcaaggc      780

ggcagagctt gtcaacaact atggcaaagg ctggagcctg aagtaccggg ccatgagcca      840

gtaccacatg gccgtggcct atcgcctgct gggccgcctg ggcagtgcca tggagtgttg      900

tgaggagtct atgaagatcg cgctgcagca cggggaccgg ccactgcagg cgctctgcct      960

gctctgcttc gctgacatcc accggagccg tggggacctg gagacagcct tccccaggta     1020

cgactccgcc atgagcatca tgaccgagat cggaaaccgc ctggggcagg tgcaggcgct     1080

gctgggtgtg gccaagtgct gggtggccag gaaggcgctg gacaaggctc tggatgccat     1140

cgagagagcc caggatctgg ccgaggaggt ggggaacaag ctgagccagc tcaagctgca     1200

ctgtctgagc gagagcattt accgcagcaa agggctgcag cgggaactgc gggcgcacgt     1260

tgtgaggttc cacgagtgcg tggaggagac ggagctctac tgcggcctgt gcggcgagtc     1320

cataggcgag aagaacagcc ggctgcaggc cctaccttgc tcccacatct tccacctcag     1380

gtgcctgcag aacaacggga cccggagctg tcccaactgc cgccgctcat ccatgaagcc     1440

tggctttgta tgactcctgg cagcaggcgt gggcttcctc ctcgccactc ctgctctttc     1500

tccactgcac gccagaggcc catttactcc tggggcagct gccaggtcgt cctcaccata     1560

gccaaggcct tggggcctgc ccagggctgc tcccctgggc ccagctcccc tccctgcctc     1620

tttgtacttt gctctttata gaaaaataaa ctgtttgtac ctggtcccag g              1671


<210>  37
<211>  1494
<212>  DNA
<213>  Homo sapiens

<400>  37
cccaactggc agcgacagct gcagacgggc tgaaccagct ttgttcccag ggtggcgcct       60

gctctccatc caggccccat tccggctccc acccgacgct gcttttgttc ccacgtttcg      120

gggggcagct ggcactgtga ttcctgcccc atgagtgcct agaggcacgg agccaccagg      180

gatcacccca cgtgggacac agggcttggg gaggatgggg caggaccaga ccaagcagca      240

gatcgagaag gggctccagc tgtaccagtc caaccagaca gagaaggcat tgcaggtgtg      300

gacaaaggtg ctggagaaga gctcggacct catggggcgc ttccgcgtgc tgggctgcct      360

ggtcacagcc cactcggaga tgggccgcta caaggagatg ctgaagttcg ctgtggtcca      420

gatcgacacg gcccgggagc tggaggatgc cgacttcctc ctggagagct acctgaacct      480

ggcacgcagc aacgagaagc tgtgcgagtt tcacaagacc atctcctact gcaagacctg      540

ccttgggctg cctggtacca gggcaggtgc ccagctcgga ggccaggtca gcctgagcat      600

gggcaatgcc ttcctgggcc tcagcgtctt ccagaaggcc ctggagagct tcgagaaggc      660

cctgcgctat gcccacaaca atgatgacgc catgctcgag tgccgcgtgt gctgcagcct      720

gggcagcttc tatgcccagg tcaaggacta cgagaaagcc ctgttcttcc cctgcaaggc      780

ggcagagctt gtcaacaact atggcaaagg ctggagcctg aagtaccggg ccatgagcca      840

gtaccacatg gccgtggcct atcgcctgct gggccgcctg ggcagtgcca tggagtgttg      900

tgaggagtct atgaagatcg cgctgcagca cggggaccgg ccactgcagg cgctctgcct      960

gctctgcttc gctgacatcc accggagccg tggggacctg gagctgagcc agctcaagct     1020

gcactgtctg agcgagagca tttaccgcag caaagggctg cagcgggaac tgcgggcgca     1080

cgttgtgagg ttccacgagt gcgtggagga gacggagctc tactgcggcc tgtgcggcga     1140

gtccataggc gagaagaaca gccggctgca ggccctacct tgctcccaca tcttccacct     1200

caggtgcctg cagaacaacg ggacccggag ctgtcccaac tgccgccgct catccatgaa     1260

gcctggcttt gtatgactcc tggcagcagg cgtgggcttc ctcctcgcca ctcctgctct     1320

ttctccactg cacgccagag gcccatttac tcctggggca gctgccaggt cgtcctcacc     1380

atagccaagg ccttggggcc tgcccagggc tgctcccctg ggcccagctc ccctccctgc     1440

ctctttgtac tttgctcttt atagaaaaat aaactgtttg tacctggtcc cagg           1494


<210>  38
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Gln Asp Gln Thr Lys Gln Gln Ile Glu Lys Gly Leu Gln Leu 
1               5                   10                  15      


Tyr Gln Ser Asn Gln Thr Glu Lys Ala Leu Gln Val Trp Thr Lys Val 
            20                  25                  30          


Leu Glu Lys Ser Ser Asp Leu Met Gly Arg Phe Arg Val Leu Gly Cys 
        35                  40                  45              


Leu Val Thr Ala His Ser Glu Met Gly Arg Tyr Lys Glu Met Leu Lys 
    50                  55                  60                  


Phe Ala Val Val Gln Ile Asp Thr Ala Arg Glu Leu Glu Asp Ala Asp 
65                  70                  75                  80  


Phe Leu Leu Glu Ser Tyr Leu Asn Leu Ala Arg Ser Asn Glu Lys Leu 
                85                  90                  95      


Cys Glu Phe His Lys Thr Ile Ser Tyr Cys Lys Thr Cys Leu Gly Leu 
            100                 105                 110         


Pro Gly Thr Arg Ala Gly Ala Gln Leu Gly Gly Gln Val Ser Leu Ser 
        115                 120                 125             


Met Gly Asn Ala Phe Leu Gly Leu Ser Val Phe Gln Lys Ala Leu Glu 
    130                 135                 140                 


Ser Phe Glu Lys Ala Leu Arg Tyr Ala His Asn Asn Asp Asp Ala Met 
145                 150                 155                 160 


Leu Glu Cys Arg Val Cys Cys Ser Leu Gly Ser Phe Tyr Ala Gln Val 
                165                 170                 175     


Lys Asp Tyr Glu Lys Ala Leu Phe Phe Pro Cys Lys Ala Ala Glu Leu 
            180                 185                 190         


Val Asn Asn Tyr Gly Lys Gly Trp Ser Leu Lys Tyr Arg Ala Met Ser 
        195                 200                 205             


Gln Tyr His Met Ala Val Ala Tyr Arg Leu Leu Gly Arg Leu Gly Ser 
    210                 215                 220                 


Ala Met Glu Cys Cys Glu Glu Ser Met Lys Ile Ala Leu Gln His Gly 
225                 230                 235                 240 


Asp Arg Pro Leu Gln Ala Leu Cys Leu Leu Cys Phe Ala Asp Ile His 
                245                 250                 255     


Arg Ser Arg Gly Asp Leu Glu Thr Ala Phe Pro Arg Tyr Asp Ser Ala 
            260                 265                 270         


Met Ser Ile Met Thr Glu Ile Gly Asn Arg Leu Gly Gln Val Gln Ala 
        275                 280                 285             


Leu Leu Gly Val Ala Lys Cys Trp Val Ala Arg Lys Ala Leu Asp Lys 
    290                 295                 300                 


Ala Leu Asp Ala Ile Glu Arg Ala Gln Asp Leu Ala Glu Glu Val Gly 
305                 310                 315                 320 


Asn Lys Leu Ser Gln Leu Lys Leu His Cys Leu Ser Glu Ser Ile Tyr 
                325                 330                 335     


Arg Ser Lys Gly Leu Gln Arg Glu Leu Arg Ala His Val Val Arg Phe 
            340                 345                 350         


His Glu Cys Val Glu Glu Thr Glu Leu Tyr Cys Gly Leu Cys Gly Glu 
        355                 360                 365             


Ser Ile Gly Glu Lys Asn Ser Arg Leu Gln Ala Leu Pro Cys Ser His 
    370                 375                 380                 


Ile Phe His Leu Arg Cys Leu Gln Asn Asn Gly Thr Arg Ser Cys Pro 
385                 390                 395                 400 


Asn Cys Arg Arg Ser Ser Met Lys Pro Gly Phe Val 
                405                 410         


<210>  39
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Gly Gln Asp Gln Thr Lys Gln Gln Ile Glu Lys Gly Leu Gln Leu 
1               5                   10                  15      


Tyr Gln Ser Asn Gln Thr Glu Lys Ala Leu Gln Val Trp Thr Lys Val 
            20                  25                  30          


Leu Glu Lys Ser Ser Asp Leu Met Gly Arg Phe Arg Val Leu Gly Cys 
        35                  40                  45              


Leu Val Thr Ala His Ser Glu Met Gly Arg Tyr Lys Glu Met Leu Lys 
    50                  55                  60                  


Phe Ala Val Val Gln Ile Asp Thr Ala Arg Glu Leu Glu Asp Ala Asp 
65                  70                  75                  80  


Phe Leu Leu Glu Ser Tyr Leu Asn Leu Ala Arg Ser Asn Glu Lys Leu 
                85                  90                  95      


Cys Glu Phe His Lys Thr Ile Ser Tyr Cys Lys Thr Cys Leu Gly Leu 
            100                 105                 110         


Pro Gly Thr Arg Ala Gly Ala Gln Leu Gly Gly Gln Val Ser Leu Ser 
        115                 120                 125             


Met Gly Asn Ala Phe Leu Gly Leu Ser Val Phe Gln Lys Ala Leu Glu 
    130                 135                 140                 


Ser Phe Glu Lys Ala Leu Arg Tyr Ala His Asn Asn Asp Asp Ala Met 
145                 150                 155                 160 


Leu Glu Cys Arg Val Cys Cys Ser Leu Gly Ser Phe Tyr Ala Gln Val 
                165                 170                 175     


Lys Asp Tyr Glu Lys Ala Leu Phe Phe Pro Cys Lys Ala Ala Glu Leu 
            180                 185                 190         


Val Asn Asn Tyr Gly Lys Gly Trp Ser Leu Lys Tyr Arg Ala Met Ser 
        195                 200                 205             


Gln Tyr His Met Ala Val Ala Tyr Arg Leu Leu Gly Arg Leu Gly Ser 
    210                 215                 220                 


Ala Met Glu Cys Cys Glu Glu Ser Met Lys Ile Ala Leu Gln His Gly 
225                 230                 235                 240 


Asp Arg Pro Leu Gln Ala Leu Cys Leu Leu Cys Phe Ala Asp Ile His 
                245                 250                 255     


Arg Ser Arg Gly Asp Leu Glu Leu Ser Gln Leu Lys Leu His Cys Leu 
            260                 265                 270         


Ser Glu Ser Ile Tyr Arg Ser Lys Gly Leu Gln Arg Glu Leu Arg Ala 
        275                 280                 285             


His Val Val Arg Phe His Glu Cys Val Glu Glu Thr Glu Leu Tyr Cys 
    290                 295                 300                 


Gly Leu Cys Gly Glu Ser Ile Gly Glu Lys Asn Ser Arg Leu Gln Ala 
305                 310                 315                 320 


Leu Pro Cys Ser His Ile Phe His Leu Arg Cys Leu Gln Asn Asn Gly 
                325                 330                 335     


Thr Arg Ser Cys Pro Asn Cys Arg Arg Ser Ser Met Lys Pro Gly Phe 
            340                 345                 350         


Val 
    


<210>  40
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  40
tgaggctgcc ttataaagca ccaagaggct gccagtggga cattttctcg gccctgccag       60

cccccaggag gaaggtgggt ctgaatctag caccatgacg gaactagaga cagccatggg      120

catgatcata gacgtctttt cccgatattc gggcagcgag ggcagcacgc agaccctgac      180

caagggggag ctcaaggtgc tgatggagaa ggagctacca ggcttcctgc agagtggaaa      240

agacaaggat gccgtggata aattgctcaa ggacctggac gccaatggag atgcccaggt      300

ggacttcagt gagttcatcg tgttcgtggc tgcaatcacg tctgcctgtc acaagtactt      360

tgagaaggca ggactcaaat gatgccctgg agatgtcaca gattcctggc agagccatgg      420

tcccaggctt cccaaaagtg tttgttggca attattcccc taggctgagc ctgctcatgt      480

acctctgatt aataaatgct tatgaaatga                                       510


<210>  41
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Thr Glu Leu Glu Thr Ala Met Gly Met Ile Ile Asp Val Phe Ser 
1               5                   10                  15      


Arg Tyr Ser Gly Ser Glu Gly Ser Thr Gln Thr Leu Thr Lys Gly Glu 
            20                  25                  30          


Leu Lys Val Leu Met Glu Lys Glu Leu Pro Gly Phe Leu Gln Ser Gly 
        35                  40                  45              


Lys Asp Lys Asp Ala Val Asp Lys Leu Leu Lys Asp Leu Asp Ala Asn 
    50                  55                  60                  


Gly Asp Ala Gln Val Asp Phe Ser Glu Phe Ile Val Phe Val Ala Ala 
65                  70                  75                  80  


Ile Thr Ser Ala Cys His Lys Tyr Phe Glu Lys Ala Gly Leu Lys 
                85                  90                  95  


<210>  42
<211>  968
<212>  DNA
<213>  Homo sapiens

<400>  42
tggagggtaa gaagtttgtc ccacgaggtt tctcttactt tgcctccgca gtatacacgt       60

acatccaaag ccggttctac cgatccccag aagtgatcct gggccacccc tacgacgtgg      120

ccattgacat gtggagcctg ggctgcatca cggcggagtt gtacacgggc taccccctgt      180

tccccgggga gaatgaggtg gagcagctgg cctgcatcat ggaggtgctg ggtctgccgc      240

cagccggctt cattcagaca gcctccagga gacagacatt ctttgattcc aaaggttttc      300

ctaaaaatat aaccaacaac agggggaaaa aaagataccc agattccaag gacctcacga      360

tggtgctgaa aacctatgac accagcttcc tggactttct cagaaggtgt ttggtatggg      420

aaccttctct tcgcatgacc ccggaccagg ccctcaagca tgcttggatt catcagtctc      480

ggaacctcaa gccacagccc aggccccaga ccctgaggaa atccaattcc tttttcccct      540

ctgagacaag gaaggacaag gttcaaggct gtcatcactc gagcagaaaa gcagatgaga      600

tcaccaaaga gactacagag aaaacaaaag atagccccac gaagcatgtt cagcattcag      660

gtgatcagca ggactgtctc cagcacggag ctgacactgt tcagctgcct caactggtag      720

acgctcccaa gaagtcagag gcagctgtcg gggcggaggt gtccatgacc tccccaggac      780

agagcaaaaa cttctccctc aagaacacaa acgttttacc ccctattgta tgacctttgc      840

tgagggtatg tcctgctcct ttccaccagt gatttgtatt aagacagcac ttatattgta      900

caatacttca gactgttttt tttaaataca taaaacttta tgttaaaaaa ctctattaac      960

atggccaa                                                               968


<210>  43
<211>  965
<212>  DNA
<213>  Homo sapiens

<400>  43
tggagggtaa gaagtttgtc ccacgaggtt tctcttactt tgcctccgca gtatacacgt       60

acatccaaag ccggttctac cgatccccag aagtgatcct gggccacccc tacgacgtgg      120

ccattgacat gtggagcctg ggctgcatca cggcggagtt gtacacgggc taccccctgt      180

tccccgggga gaatgaggtg gagcagctgg cctgcatcat ggaggtgctg ggtctgccgc      240

cagccggctt cattcagaca gcctccagga gacagacatt ctttgattcc aaaggttttc      300

ctaaaaatat aaccaacaac agggggaaaa aaagataccc agattccaag gacctcacga      360

tggtgctgaa aacctatgac accagcttcc tggactttct cagaaggtgt ttggtatggg      420

aaccttctct tcgcatgacc ccggaccagg ccctcaagca tgcttggatt catcagtctc      480

ggaacctcaa gccacagccc aggccccaga ccctgaggaa atccaattcc tttttcccct      540

ctgagacaag gaaggacaag gttcaaggct gtcatcactc gagcagaaaa gatgagatca      600

ccaaagagac tacagagaaa acaaaagata gccccacgaa gcatgttcag cattcaggtg      660

atcagcagga ctgtctccag cacggagctg acactgttca gctgcctcaa ctggtagacg      720

ctcccaagaa gtcagaggca gctgtcgggg cggaggtgtc catgacctcc ccaggacaga      780

gcaaaaactt ctccctcaag aacacaaacg ttttaccccc tattgtatga cctttgctga      840

gggtatgtcc tgctcctttc caccagtgat ttgtattaag acagcactta tattgtacaa      900

tacttcagac tgtttttttt aaatacataa aactttatgt taaaaaactc tattaacatg      960

gccaa                                                                  965


<210>  44
<211>  1864
<212>  DNA
<213>  Homo sapiens

<400>  44
agagtcagtg tgagctgttg aaagcctgca gctaaacacc agtgttactt cactcccctt       60

tgtggacacc aaggggaaga agaatacggt aagcttccca cacattagca agaaagtcct      120

gctgaagtca tccctgctgt atcaggagaa tcaagctcac aatcagatgc cggcctcaga      180

gctcaaggct tcagaaatac ctttccaccc tagcattaaa acccaggatc ccaaggcaga      240

ggagaagtca ccaaagaagc aaaaggtgac tctgacagcg gcagaggccc taaagctttt      300

taagaaccag ctgtctccat atgaacaaag tgaaatcctg ggctacgcgg agctgtggtt      360

cctgggtctt gaagccaaga agctcgacac ggctcctgag aaatttagca agacgagttt      420

tgatgatgag catggcttct atctgaaggt cctgcatgat cacattgcct accgctatga      480

agttctggag acaatcggga aggggtcctt tggacaggtg gccaagtgct tggatcacaa      540

aaacaatgag ctggtggccc tgaaaatcat caggaacaag aagaggtttc accagcaggc      600

cctgatggag ctgaagatcc tggaagctct cagaaagaag gacaaagaca acacctacaa      660

tgtggtgcat atgaaggact ttttctactt tcgcaatcac ttctgcatca cctttgagct      720

cctgggaatc aacttgtatg agttgatgaa gaataacaac tttcaaggct tcagtctgtc      780

catagttcgg cgcttcactc tctctgtttt gaagtgcttg cagatgcttt cggtagagaa      840

aatcattcac tgtgatctca agcccgaaaa tatagtgcta taccaaaagg gccaagcctc      900

tgttaaagtc attgactttg gatcaagctg ttatgaacac cagaaagtat acacgtacat      960

ccaaagccgg ttctaccgat ccccagaagt gatcctgggc cacccctacg acgtggccat     1020

tgacatgtgg agcctgggct gcatcacggc ggagttgtac acgggctacc ccctgttccc     1080

cggggagaat gaggtggagc agctggcctg catcatggag gtgctgggtc tgccgccagc     1140

cggcttcatt cagacagcct ccaggagaca gacattcttt gattccaaag gttttcctaa     1200

aaatataacc aacaacaggg ggaaaaaaag atacccagat tccaaggacc tcacgatggt     1260

gctgaaaacc tatgacacca gcttcctgga ctttctcaga aggtgtttgg tatgggaacc     1320

ttctcttcgc atgaccccgg accaggccct caagcatgct tggattcatc agtctcggaa     1380

cctcaagcca cagcccaggc cccagaccct gaggaaatcc aattcctttt tcccctctga     1440

gacaaggaag gacaaggttc aaggctgtca tcactcgagc agaaaagcag atgagatcac     1500

caaagagact acagagaaaa caaaagatag ccccacgaag catgttcagc attcaggtga     1560

tcagcaggac tgtctccagc acggagctga cactgttcag ctgcctcaac tggtagacgc     1620

tcccaagaag tcagaggcag ctgtcggggc ggaggtgtcc atgacctccc caggacagag     1680

caaaaacttc tccctcaaga acacaaacgt tttaccccct attgtatgac ctttgctgag     1740

ggtatgtcct gctcctttcc accagtgatt tgtattaaga cagcacttat attgtacaat     1800

acttcagact gtttttttta aatacataaa actttatgtt aaaaaactct attaacatgg     1860

ccaa                                                                  1864


<210>  45
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Trp Ser Leu Gly Cys Ile Thr Ala Glu Leu Tyr Thr Gly Tyr Pro 
1               5                   10                  15      


Leu Phe Pro Gly Glu Asn Glu Val Glu Gln Leu Ala Cys Ile Met Glu 
            20                  25                  30          


Val Leu Gly Leu Pro Pro Ala Gly Phe Ile Gln Thr Ala Ser Arg Arg 
        35                  40                  45              


Gln Thr Phe Phe Asp Ser Lys Gly Phe Pro Lys Asn Ile Thr Asn Asn 
    50                  55                  60                  


Arg Gly Lys Lys Arg Tyr Pro Asp Ser Lys Asp Leu Thr Met Val Leu 
65                  70                  75                  80  


Lys Thr Tyr Asp Thr Ser Phe Leu Asp Phe Leu Arg Arg Cys Leu Val 
                85                  90                  95      


Trp Glu Pro Ser Leu Arg Met Thr Pro Asp Gln Ala Leu Lys His Ala 
            100                 105                 110         


Trp Ile His Gln Ser Arg Asn Leu Lys Pro Gln Pro Arg Pro Gln Thr 
        115                 120                 125             


Leu Arg Lys Ser Asn Ser Phe Phe Pro Ser Glu Thr Arg Lys Asp Lys 
    130                 135                 140                 


Val Gln Gly Cys His His Ser Ser Arg Lys Ala Asp Glu Ile Thr Lys 
145                 150                 155                 160 


Glu Thr Thr Glu Lys Thr Lys Asp Ser Pro Thr Lys His Val Gln His 
                165                 170                 175     


Ser Gly Asp Gln Gln Asp Cys Leu Gln His Gly Ala Asp Thr Val Gln 
            180                 185                 190         


Leu Pro Gln Leu Val Asp Ala Pro Lys Lys Ser Glu Ala Ala Val Gly 
        195                 200                 205             


Ala Glu Val Ser Met Thr Ser Pro Gly Gln Ser Lys Asn Phe Ser Leu 
    210                 215                 220                 


Lys Asn Thr Asn Val Leu Pro Pro Ile Val 
225                 230                 


<210>  46
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Trp Ser Leu Gly Cys Ile Thr Ala Glu Leu Tyr Thr Gly Tyr Pro 
1               5                   10                  15      


Leu Phe Pro Gly Glu Asn Glu Val Glu Gln Leu Ala Cys Ile Met Glu 
            20                  25                  30          


Val Leu Gly Leu Pro Pro Ala Gly Phe Ile Gln Thr Ala Ser Arg Arg 
        35                  40                  45              


Gln Thr Phe Phe Asp Ser Lys Gly Phe Pro Lys Asn Ile Thr Asn Asn 
    50                  55                  60                  


Arg Gly Lys Lys Arg Tyr Pro Asp Ser Lys Asp Leu Thr Met Val Leu 
65                  70                  75                  80  


Lys Thr Tyr Asp Thr Ser Phe Leu Asp Phe Leu Arg Arg Cys Leu Val 
                85                  90                  95      


Trp Glu Pro Ser Leu Arg Met Thr Pro Asp Gln Ala Leu Lys His Ala 
            100                 105                 110         


Trp Ile His Gln Ser Arg Asn Leu Lys Pro Gln Pro Arg Pro Gln Thr 
        115                 120                 125             


Leu Arg Lys Ser Asn Ser Phe Phe Pro Ser Glu Thr Arg Lys Asp Lys 
    130                 135                 140                 


Val Gln Gly Cys His His Ser Ser Arg Lys Asp Glu Ile Thr Lys Glu 
145                 150                 155                 160 


Thr Thr Glu Lys Thr Lys Asp Ser Pro Thr Lys His Val Gln His Ser 
                165                 170                 175     


Gly Asp Gln Gln Asp Cys Leu Gln His Gly Ala Asp Thr Val Gln Leu 
            180                 185                 190         


Pro Gln Leu Val Asp Ala Pro Lys Lys Ser Glu Ala Ala Val Gly Ala 
        195                 200                 205             


Glu Val Ser Met Thr Ser Pro Gly Gln Ser Lys Asn Phe Ser Leu Lys 
    210                 215                 220                 


Asn Thr Asn Val Leu Pro Pro Ile Val 
225                 230             


<210>  47
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Pro Ala Ser Glu Leu Lys Ala Ser Glu Ile Pro Phe His Pro Ser 
1               5                   10                  15      


Ile Lys Thr Gln Asp Pro Lys Ala Glu Glu Lys Ser Pro Lys Lys Gln 
            20                  25                  30          


Lys Val Thr Leu Thr Ala Ala Glu Ala Leu Lys Leu Phe Lys Asn Gln 
        35                  40                  45              


Leu Ser Pro Tyr Glu Gln Ser Glu Ile Leu Gly Tyr Ala Glu Leu Trp 
    50                  55                  60                  


Phe Leu Gly Leu Glu Ala Lys Lys Leu Asp Thr Ala Pro Glu Lys Phe 
65                  70                  75                  80  


Ser Lys Thr Ser Phe Asp Asp Glu His Gly Phe Tyr Leu Lys Val Leu 
                85                  90                  95      


His Asp His Ile Ala Tyr Arg Tyr Glu Val Leu Glu Thr Ile Gly Lys 
            100                 105                 110         


Gly Ser Phe Gly Gln Val Ala Lys Cys Leu Asp His Lys Asn Asn Glu 
        115                 120                 125             


Leu Val Ala Leu Lys Ile Ile Arg Asn Lys Lys Arg Phe His Gln Gln 
    130                 135                 140                 


Ala Leu Met Glu Leu Lys Ile Leu Glu Ala Leu Arg Lys Lys Asp Lys 
145                 150                 155                 160 


Asp Asn Thr Tyr Asn Val Val His Met Lys Asp Phe Phe Tyr Phe Arg 
                165                 170                 175     


Asn His Phe Cys Ile Thr Phe Glu Leu Leu Gly Ile Asn Leu Tyr Glu 
            180                 185                 190         


Leu Met Lys Asn Asn Asn Phe Gln Gly Phe Ser Leu Ser Ile Val Arg 
        195                 200                 205             


Arg Phe Thr Leu Ser Val Leu Lys Cys Leu Gln Met Leu Ser Val Glu 
    210                 215                 220                 


Lys Ile Ile His Cys Asp Leu Lys Pro Glu Asn Ile Val Leu Tyr Gln 
225                 230                 235                 240 


Lys Gly Gln Ala Ser Val Lys Val Ile Asp Phe Gly Ser Ser Cys Tyr 
                245                 250                 255     


Glu His Gln Lys Val Tyr Thr Tyr Ile Gln Ser Arg Phe Tyr Arg Ser 
            260                 265                 270         


Pro Glu Val Ile Leu Gly His Pro Tyr Asp Val Ala Ile Asp Met Trp 
        275                 280                 285             


Ser Leu Gly Cys Ile Thr Ala Glu Leu Tyr Thr Gly Tyr Pro Leu Phe 
    290                 295                 300                 


Pro Gly Glu Asn Glu Val Glu Gln Leu Ala Cys Ile Met Glu Val Leu 
305                 310                 315                 320 


Gly Leu Pro Pro Ala Gly Phe Ile Gln Thr Ala Ser Arg Arg Gln Thr 
                325                 330                 335     


Phe Phe Asp Ser Lys Gly Phe Pro Lys Asn Ile Thr Asn Asn Arg Gly 
            340                 345                 350         


Lys Lys Arg Tyr Pro Asp Ser Lys Asp Leu Thr Met Val Leu Lys Thr 
        355                 360                 365             


Tyr Asp Thr Ser Phe Leu Asp Phe Leu Arg Arg Cys Leu Val Trp Glu 
    370                 375                 380                 


Pro Ser Leu Arg Met Thr Pro Asp Gln Ala Leu Lys His Ala Trp Ile 
385                 390                 395                 400 


His Gln Ser Arg Asn Leu Lys Pro Gln Pro Arg Pro Gln Thr Leu Arg 
                405                 410                 415     


Lys Ser Asn Ser Phe Phe Pro Ser Glu Thr Arg Lys Asp Lys Val Gln 
            420                 425                 430         


Gly Cys His His Ser Ser Arg Lys Ala Asp Glu Ile Thr Lys Glu Thr 
        435                 440                 445             


Thr Glu Lys Thr Lys Asp Ser Pro Thr Lys His Val Gln His Ser Gly 
    450                 455                 460                 


Asp Gln Gln Asp Cys Leu Gln His Gly Ala Asp Thr Val Gln Leu Pro 
465                 470                 475                 480 


Gln Leu Val Asp Ala Pro Lys Lys Ser Glu Ala Ala Val Gly Ala Glu 
                485                 490                 495     


Val Ser Met Thr Ser Pro Gly Gln Ser Lys Asn Phe Ser Leu Lys Asn 
            500                 505                 510         


Thr Asn Val Leu Pro Pro Ile Val 
        515                 520 


<210>  48
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense sequence of HYAL2 primer

<400>  48
aggaagagag ttttaaattt agtagggtgt gagagga                                37


<210>  49
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense sequence HYAL2 primer

<400>  49
cagtaatacg actcactata gggagaaggc tctcatccat attataaaaa accccc           56


<210>  50
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense sequence of HYAL2-is-310 primer

<400>  50
aggaagagag tttttttggg gtgagttttt ttagt                                  35


<210>  51
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense sequence HYAL2-is-310 primer

<400>  51
cagtaatacg actcactata gggagaaggc tcacctaatc ctaaacccat aacctt           56


<210>  52
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense sequence of HYAL2-is-325 primer

<400>  52
aggaagagag ttgtttagtt tttgaggttt tttgg                                  35


<210>  53
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense sequence HYAL2-is-325 primer

<400>  53
cagtaatacg actcactata gggagaaggc tattacactc cctccctctc ctaac            55


<210>  54
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense sequence MGRN1 primer

<400>  54
aggaagagag ttttggggta taagggaagt ttaag                                  35


<210>  55
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense sequence MGRN1 primer

<400>  55
cagtaatacg actcactata gggagaaggc tcctaaccaa caaaaaacct aaaaaa           56


<210>  56
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense sequence RPTOR primer

<400>  56
aggaagagag gtggggtttt tgtagtagtt gaga                                   34


<210>  57
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense sequence RPTOR primer

<400>  57
cagtaatacg actcactata gggagaaggc ttaataaccc aaaaccaaac cctaac           56


<210>  58
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense sequence of SLC22A18 primer

<400>  58
aggaagagag taagtggaat tttggtattt ttgga                                  35


<210>  59
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense sequence SLC22A18 primer

<400>  59
cagtaatacg actcactata gggagaaggc tcactccaaa cctaaactca cctcta           56


<210>  60
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense sequence FUT7 primer

<400>  60
aggaagagag gaagaggaag ggatttagtt tgaag                                  35


<210>  61
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense sequence FUT7 primer

<400>  61
cagtaatacg actcactata gggagaaggc tacaaacctt aacctcccaa aatact           56


<210>  62
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense sequence RAPSN primer

<400>  62
aggaagagag gatttttagt tggtgagagg tttga                                  35


<210>  63
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense sequence RAPSN primer

<400>  63
cagtaatacg actcactata gggagaaggc taaaaccact aaattaccca accaaa           56


<210>  64
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense sequence S100P primer

<400>  64
aggaagagag ggaaggtggg tttgaattta gtatt                                  35


<210>  65
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense sequence S100P primer

<400>  65
cagtaatacg actcactata gggagaaggc tctatccctc ttacctctaa acccct           56


<210>  66
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sense sequence DYRK4 primer

<400>  66
aggaagagag ggttttttta aaattggttt tggat                                  35


<210>  67
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense sequence DYRK4 primer

<400>  67
cagtaatacg actcactata gggagaaggc taaaccccat ttttattccc ataat            55


