                         SEQUENCE LISTING

<110>  Snutch, Terrance P.
       Rungta, Ravi
       Hyun, Choi
       Tyson, John
       MacVicar, Brian
 
<120>  METHODS of TREATING BRAIN EDEMA

<130>  TPSD-001/01WO

<150>  US 62/131,182
<151>  2015-03-10

<150>  US 62/117,287
<151>  2015-02-17

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ser Ser Val Thr Ala Leu Gly Gln Ala Arg Ser Ser Gly Pro 
1               5                   10                  15      


Gly Met Ala Pro Ser Ala Cys Cys Cys Ser Pro Ala Ala Leu Gln Arg 
            20                  25                  30          


Arg Leu Pro Ile Leu Ala Trp Leu Pro Ser Tyr Ser Leu Gln Trp Leu 
        35                  40                  45              


Lys Met Asp Phe Val Ala Gly Leu Ser Val Gly Leu Thr Ala Ile Pro 
    50                  55                  60                  


Gln Ala Leu Ala Tyr Ala Glu Val Ala Gly Leu Pro Pro Gln Tyr Gly 
65                  70                  75                  80  


Leu Tyr Ser Ala Phe Met Gly Cys Phe Val Tyr Phe Phe Leu Gly Thr 
                85                  90                  95      


Ser Arg Asp Val Thr Leu Gly Pro Thr Ala Ile Met Ser Leu Leu Val 
            100                 105                 110         


Ser Phe Tyr Thr Phe His Glu Pro Ala Tyr Ala Val Leu Leu Ala Phe 
        115                 120                 125             


Leu Ser Gly Cys Ile Gln Leu Ala Met Gly Val Leu Arg Leu Gly Phe 
    130                 135                 140                 


Leu Leu Asp Phe Ile Ser Tyr Pro Val Ile Lys Gly Phe Thr Ser Ala 
145                 150                 155                 160 


Ala Ala Val Thr Ile Gly Phe Gly Gln Ile Lys Asn Leu Leu Gly Leu 
                165                 170                 175     


Gln Asn Ile Pro Arg Pro Phe Phe Leu Gln Val Tyr His Thr Phe Leu 
            180                 185                 190         


Arg Ile Ala Glu Thr Arg Val Gly Asp Ala Val Leu Gly Leu Val Cys 
        195                 200                 205             


Met Leu Leu Leu Leu Val Leu Lys Leu Met Arg Asp His Val Pro Pro 
    210                 215                 220                 


Val His Pro Glu Met Pro Pro Gly Val Arg Leu Ser Arg Gly Leu Val 
225                 230                 235                 240 


Trp Ala Ala Thr Thr Ala Arg Asn Ala Leu Val Val Ser Phe Ala Ala 
                245                 250                 255     


Leu Val Ala Tyr Ser Phe Glu Val Thr Gly Tyr Gln Pro Phe Ile Leu 
            260                 265                 270         


Thr Gly Glu Thr Ala Glu Gly Leu Pro Pro Val Arg Ile Pro Pro Phe 
        275                 280                 285             


Ser Val Thr Thr Ala Asn Gly Thr Ile Ser Phe Thr Glu Met Val Gln 
    290                 295                 300                 


Asp Met Gly Ala Gly Leu Ala Val Val Pro Leu Met Gly Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ala Val Ala Lys Ala Phe Ala Ser Gln Asn Asn Tyr Arg Ile 
                325                 330                 335     


Asp Ala Asn Gln Glu Leu Leu Ala Ile Gly Leu Thr Asn Met Leu Gly 
            340                 345                 350         


Ser Leu Val Ser Ser Tyr Pro Val Thr Gly Ser Phe Gly Arg Thr Ala 
        355                 360                 365             


Val Asn Ala Gln Ser Gly Val Cys Thr Pro Ala Gly Gly Leu Val Thr 
    370                 375                 380                 


Gly Val Leu Val Leu Leu Ser Leu Asp Tyr Leu Thr Ser Leu Phe Tyr 
385                 390                 395                 400 


Tyr Ile Pro Lys Ser Ala Leu Ala Ala Val Ile Ile Met Ala Val Ala 
                405                 410                 415     


Pro Leu Phe Asp Thr Lys Ile Phe Arg Thr Leu Trp Arg Val Lys Arg 
            420                 425                 430         


Leu Asp Leu Leu Pro Leu Cys Val Thr Phe Leu Leu Cys Phe Trp Glu 
        435                 440                 445             


Val Gln Tyr Gly Ile Leu Ala Gly Ala Leu Val Ser Leu Leu Met Leu 
    450                 455                 460                 


Leu His Ser Ala Ala Arg Pro Glu Thr Lys Val Ser Glu Gly Pro Val 
465                 470                 475                 480 


Leu Val Leu Gln Pro Ala Ser Gly Leu Ser Phe Pro Ala Met Glu Ala 
                485                 490                 495     


Leu Arg Glu Glu Ile Leu Ser Arg Ala Leu Glu Val Ser Pro Pro Arg 
            500                 505                 510         


Cys Leu Val Leu Glu Cys Thr His Val Cys Ser Ile Asp Tyr Thr Val 
        515                 520                 525             


Val Leu Gly Leu Gly Glu Leu Leu Gln Asp Phe Gln Lys Gln Gly Val 
    530                 535                 540                 


Ala Leu Ala Phe Val Gly Leu Gln Val Pro Val Leu Arg Val Leu Leu 
545                 550                 555                 560 


Ser Ala Asp Leu Lys Gly Phe Gln Tyr Phe Ser Thr Leu Glu Glu Ala 
                565                 570                 575     


Glu Lys His Leu Arg Gln Glu Pro Gly Thr Gln Pro Tyr Asn Ile Arg 
            580                 585                 590         


Glu Asp Ser Ile Leu Asp Gln Lys Val Ala Leu Leu Lys Ala 
        595                 600                 605     


<210>  2
<211>  590
<212>  PRT
<213>  Ratus norvegicus

<400>  2

Met Ala Pro Asp Thr His Cys Cys Ser Arg Ala Asp Leu Arg Arg Arg 
1               5                   10                  15      


Leu Pro Val Leu Ala Trp Leu Pro Asn Tyr Ser Leu Arg Trp Leu Arg 
            20                  25                  30          


Met Asp Val Ile Ala Gly Leu Ser Val Gly Leu Thr Val Ile Pro Gln 
        35                  40                  45              


Ala Leu Ala Tyr Ala Glu Val Ala Gly Leu Pro Pro Gln Tyr Gly Leu 
    50                  55                  60                  


Tyr Ser Ala Phe Met Gly Cys Phe Val Tyr Phe Val Leu Gly Thr Ser 
65                  70                  75                  80  


Arg Asp Val Thr Leu Gly Pro Thr Ala Ile Met Ser Leu Leu Val Ser 
                85                  90                  95      


Tyr Tyr Thr Phe Arg Glu Pro Ala Tyr Ala Val Leu Leu Ala Phe Leu 
            100                 105                 110         


Ser Gly Cys Ile Gln Leu Ala Met Gly Leu Leu His Leu Gly Phe Leu 
        115                 120                 125             


Leu Asp Phe Ile Ser Cys Pro Val Ile Lys Gly Phe Thr Ser Ala Ala 
    130                 135                 140                 


Ser Ile Thr Ile Gly Phe Gly Gln Val Lys Asn Leu Leu Gly Leu Gln 
145                 150                 155                 160 


Asn Ile Pro Arg Gln Phe Phe Leu Gln Val Tyr His Thr Phe Leu His 
                165                 170                 175     


Ile Gly Glu Thr Arg Val Gly Asp Ala Ile Leu Gly Leu Val Cys Met 
            180                 185                 190         


Val Leu Leu Leu Val Leu Lys Leu Met Arg Glu His Ile Pro Pro Pro 
        195                 200                 205             


His Pro Glu Met Pro Leu Gly Val Lys Phe Ser Arg Gly Leu Val Trp 
    210                 215                 220                 


Thr Val Thr Thr Ala Arg Asn Ala Leu Val Val Ser Phe Ala Ala Leu 
225                 230                 235                 240 


Ile Ala Tyr Ala Phe Glu Val Thr Gly Ser His Pro Phe Ile Leu Thr 
                245                 250                 255     


Gly Lys Ile Ala Gln Gly Leu Pro Pro Val Arg Met Pro Pro Phe Ser 
            260                 265                 270         


Val Thr Thr Asp Asn Lys Thr Ile Ser Phe Ser Glu Met Val Gln Val 
        275                 280                 285             


Ser Gly Cys Arg Ala Ser Ser Met Ala Glu Ala Glu Arg Leu His Cys 
    290                 295                 300                 


Pro Phe Ser Leu Ala Ser Gln Asn Asn Tyr Arg Ile Asp Ala Asn Gln 
305                 310                 315                 320 


Glu Leu Leu Ala Ile Gly Leu Thr Asn Val Leu Gly Ser Leu Val Ser 
                325                 330                 335     


Ser Tyr Pro Val Thr Gly Ser Phe Gly Arg Thr Ala Val Asn Ala Gln 
            340                 345                 350         


Thr Gly Val Cys Thr Pro Ala Gly Gly Leu Val Thr Gly Val Leu Val 
        355                 360                 365             


Leu Leu Ser Leu Asp Tyr Leu Thr Leu Leu Phe Tyr Tyr Ile Pro Lys 
    370                 375                 380                 


Ser Ala Leu Ala Ala Val Ile Ile Met Ala Val Ala Pro Leu Phe Asp 
385                 390                 395                 400 


Val Lys Ile Phe Arg Arg Leu Trp Leu Val Gln Arg Leu Asp Leu Leu 
                405                 410                 415     


Pro Leu Cys Val Thr Phe Leu Leu Ser Phe Trp Glu Ile Gln Tyr Gly 
            420                 425                 430         


Ile Leu Ala Gly Thr Leu Val Ser Leu Leu Ile Leu Leu His Ser Val 
        435                 440                 445             


Ala Arg Pro Lys Thr Gln Val Ser Glu Gly Gln Ile Leu Val Leu Gln 
    450                 455                 460                 


Pro Ala Ser Gly Leu His Phe Pro Ala Val Asp Ala Leu Arg Glu Ala 
465                 470                 475                 480 


Met Thr Lys Arg Ala Leu Glu Ala Ser Pro Pro Arg Ser Ala Val Leu 
                485                 490                 495     


Glu Cys Thr His Val Ser Asn Ile Asp Tyr Thr Val Ile Leu Gly Leu 
            500                 505                 510         


Gly Glu Leu Leu Glu Asp Phe Gln Lys Lys Gly Val Thr Leu Ala Phe 
        515                 520                 525             


Val Gly Leu Gln Val Pro Val Leu Arg Thr Leu Leu Ala Ala Asp Leu 
    530                 535                 540                 


Lys Gly Phe Gln Tyr Phe Thr Thr Leu Glu Glu Ala Glu Lys Ser Leu 
545                 550                 555                 560 


Gln Gln Glu Pro Gly Thr Gln Pro Tyr Ser Ile Arg Glu Asp Thr Ala 
                565                 570                 575     


Pro Glu His Arg Ser Ser Leu Leu Lys Ser Pro Ser Gly Pro 
            580                 585                 590 


<210>  3
<211>  593
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Pro Asp Thr Cys Cys Cys Ser Ala Thr Ala Leu Arg Arg Arg 
1               5                   10                  15      


Leu Pro Val Leu Ala Trp Val Pro Asp Tyr Ser Leu Gln Trp Leu Arg 
            20                  25                  30          


Leu Asp Phe Ile Ala Gly Leu Ser Val Gly Leu Thr Val Ile Pro Gln 
        35                  40                  45              


Ala Leu Ala Tyr Ala Glu Val Ala Gly Leu Pro Pro Gln Tyr Gly Leu 
    50                  55                  60                  


Tyr Ser Ala Phe Met Gly Cys Phe Val Tyr Phe Phe Leu Gly Thr Ser 
65                  70                  75                  80  


Arg Asp Val Thr Leu Gly Pro Thr Ala Ile Met Ser Leu Leu Val Ser 
                85                  90                  95      


Phe Tyr Thr Phe Arg Glu Pro Ala Tyr Ala Val Leu Leu Ala Phe Leu 
            100                 105                 110         


Ser Gly Cys Ile Gln Leu Ala Met Gly Leu Leu His Leu Gly Phe Leu 
        115                 120                 125             


Leu Asp Phe Ile Ser Cys Pro Val Ile Lys Gly Phe Thr Ser Ala Ala 
    130                 135                 140                 


Ser Ile Thr Ile Gly Phe Gly Gln Ile Lys Asn Leu Leu Gly Leu Gln 
145                 150                 155                 160 


Lys Ile Pro Arg Gln Phe Phe Leu Gln Val Tyr His Thr Phe Leu His 
                165                 170                 175     


Ile Gly Glu Thr Arg Val Gly Asp Ala Val Leu Gly Leu Ala Ser Met 
            180                 185                 190         


Leu Leu Leu Leu Val Leu Lys Cys Met Arg Glu His Met Pro Pro Pro 
        195                 200                 205             


His Pro Glu Met Pro Leu Ala Val Lys Phe Ser Arg Gly Leu Val Trp 
    210                 215                 220                 


Thr Val Thr Thr Ala Arg Asn Ala Leu Val Val Ser Ser Ala Ala Leu 
225                 230                 235                 240 


Ile Ala Tyr Ala Phe Glu Val Thr Gly Ser His Pro Phe Val Leu Thr 
                245                 250                 255     


Gly Lys Ile Ala Glu Gly Leu Pro Pro Val Arg Ile Pro Pro Phe Ser 
            260                 265                 270         


Val Thr Arg Asp Asn Lys Thr Ile Ser Phe Ser Glu Met Val Gln Asp 
        275                 280                 285             


Met Gly Ala Gly Leu Ala Val Val Pro Leu Met Gly Leu Leu Glu Ser 
    290                 295                 300                 


Ile Ala Val Ala Lys Ser Phe Ala Ser Gln Asn Asn Tyr Arg Ile Asp 
305                 310                 315                 320 


Ala Asn Gln Glu Leu Leu Ala Ile Gly Leu Thr Asn Val Leu Gly Ser 
                325                 330                 335     


Leu Val Ser Ser Tyr Pro Val Thr Gly Ser Phe Gly Arg Thr Ala Val 
            340                 345                 350         


Asn Ala Gln Thr Gly Val Cys Thr Pro Ala Gly Gly Leu Val Thr Gly 
        355                 360                 365             


Ala Leu Val Leu Leu Ser Leu Asn Tyr Leu Thr Ser Leu Phe Ser Tyr 
    370                 375                 380                 


Ile Pro Lys Ser Ala Leu Ala Ala Val Ile Ile Thr Ala Val Thr Pro 
385                 390                 395                 400 


Leu Phe Asp Val Lys Ile Phe Arg Ser Leu Trp Arg Val Gln Arg Leu 
                405                 410                 415     


Asp Leu Leu Pro Leu Cys Val Thr Phe Leu Leu Ser Phe Trp Glu Ile 
            420                 425                 430         


Gln Tyr Gly Ile Leu Ala Gly Ser Leu Val Ser Leu Leu Ile Leu Leu 
        435                 440                 445             


His Ser Val Ala Arg Pro Lys Thr Gln Val Ser Glu Gly Gln Ile Phe 
    450                 455                 460                 


Val Leu Gln Pro Ala Ser Gly Leu Tyr Phe Pro Ala Ile Asp Ala Leu 
465                 470                 475                 480 


Arg Glu Ala Ile Thr Asn Arg Ala Leu Glu Ala Ser Pro Pro Arg Ser 
                485                 490                 495     


Ala Val Leu Glu Cys Thr His Ile Ser Ser Val Asp Tyr Thr Val Ile 
            500                 505                 510         


Val Gly Leu Gly Glu Leu Leu Glu Asp Phe Gln Lys Lys Gly Val Ala 
        515                 520                 525             


Leu Ala Phe Val Gly Leu Gln Val Pro Val Leu Arg Thr Leu Leu Ala 
    530                 535                 540                 


Ala Asp Leu Lys Gly Phe Arg Tyr Phe Thr Thr Leu Glu Glu Ala Glu 
545                 550                 555                 560 


Lys Phe Leu Gln Gln Glu Pro Gly Thr Glu Pro Asn Ser Ile His Glu 
                565                 570                 575     


Asp Ala Val Pro Glu Gln Arg Ser Ser Leu Leu Lys Ser Pro Ser Gly 
            580                 585                 590         


Pro 
    


<210>  4
<211>  2930
<212>  DNA
<213>  Homo sapiens

<400>  4
acgtgcgcgc cagaccccgc cccggcctgt ccccggcgat tcctgcggac ccagctgcgg       60

cgacgccagg agaccccaag ctgcatcgcc gagtggaagc aactagaact ccagggctgt      120

gaaagccaca ggtgggggct gagcgaggcg tggcctcagg agcggaggac ccccccactc      180

tccctcgagc gccgcagtcc accgtagcgg gtggagcccg ccttggtgcg cagttggaaa      240

acctcggagc cccgctggat ctcctggctg ccacccgcac cccccgccag cctacgcccc      300

accgtagaga tgccttcttc ggtgacggcg ctgggtcagg ccaggtcctc tggccccggg      360

atggccccga gcgcctgctg ctgctcccct gcggccctgc agaggaggct gcccatcctg      420

gcgtggctgc ccagctactc cctgcagtgg ctgaagatgg atttcgtcgc cggcctctca      480

gttggcctca ctgccattcc ccaggcgctg gcctatgctg aagtggctgg actcccgccc      540

cagtatggcc tctactctgc cttcatgggc tgcttcgtgt atttcttcct gggcacctcc      600

cgggatgtga ctctgggccc caccgccatt atgtccctcc tggtctcctt ctacaccttc      660

catgagcccg cctacgctgt gctgctggcc ttcctgtccg gctgcatcca gctggccatg      720

ggggtcctgc gtttggggtt cctgctggac ttcatttcct accccgtcat taaaggcttc      780

acctctgctg ctgccgtcac catcggcttt ggacagatca agaacctgct gggactacag      840

aacatcccca ggccgttctt cctgcaggtg taccacacct tcctcaggat tgcagagacc      900

agggtaggtg acgccgtcct ggggctggtc tgcatgctgc tgctgctggt gctgaagctg      960

atgcgggacc acgtgcctcc cgtccacccc gagatgcccc ctggtgtgcg gctcagccgt     1020

gggctggtct gggctgccac gacagctcgc aacgccctgg tggtctcctt cgcagccctg     1080

gttgcgtact ccttcgaggt gactggatac cagcctttca tcctaacagg ggagacagct     1140

gaggggctcc ctccagtccg gatcccgccc ttctcagtga ccacagccaa cgggacgatc     1200

tccttcaccg agatggtgca ggacatggga gccgggctgg ccgtggtgcc cctgatgggc     1260

ctcctggaga gcattgcggt ggccaaagcc ttcgcatctc agaataatta ccgcatcgat     1320

gccaaccagg agctgctggc catcggtctc accaacatgt tgggctccct cgtctcctcc     1380

tacccggtca caggcagctt tggacggaca gccgtgaacg ctcagtcggg ggtgtgcacc     1440

ccggcggggg gcctggtgac gggagtgctg gtgctgctgt ctctggacta cctgacctca     1500

ctgttctact acatccccaa gtctgccctg gctgccgtca tcatcatggc cgtggccccg     1560

ctgttcgaca ccaagatctt caggacgctc tggcgtgtta agaggctgga cctgctgccc     1620

ctgtgcgtga ccttcctgct gtgcttctgg gaggtgcagt acggcatcct ggccggggcc     1680

ctggtgtctc tgctcatgct cctgcactct gcagccaggc ctgagaccaa ggtgtcagag     1740

gggccggttc tggtcctgca gccggccagc ggcctgtcct tccctgccat ggaggctctg     1800

cgggaggaga tcctaagccg ggccctggaa gtgtccccgc cacgctgcct ggtcctggag     1860

tgcacccatg tctgcagcat cgactacact gtggtgctgg gactcggcga gctcctccag     1920

gacttccaga agcagggcgt cgccctggcc tttgtgggcc tgcaggtccc cgttctccgt     1980

gtcctgctgt ccgctgacct gaaggggttc cagtacttct ctaccctgga agaagcagag     2040

aagcacctga ggcaggagcc agggacccag ccctacaaca tcagagaaga ctccattctg     2100

gaccaaaagg ttgccctgct caaggcataa tggggccacc cgtgggcatc cacagtttgc     2160

agggtgttcc ggaaggttct tgtcactgtg attggatgct ggatgccgcc tgatagacat     2220

gctggcctgg ctgagaaacc cctgagcagg taacccaggg aagagaagga agccaggcct     2280

ggaggtccac ggcagtggga gtggggctca ctggcttcct gtgggatgac tggaaaatga     2340

cctcgctgct gttccctggc atgaccctct ttggaagagt ggtttggaga gagccttcta     2400

gaatgacaga ctgtgcgagg aagcaggggc aggggtttcc agcccgggct gtgcgaggca     2460

tcctggggct ggcagcacct tcccggctca ccagtgccac ctgcggggga gggacggggc     2520

aggcaggagt ctgggaggcg ggtccgctcc tcttgtctgc ggcatctgtg ctctccgaga     2580

gaaaaccaag gtgtgtcaaa tgacgtcaag tctctattta aaaataattt tgtgttttct     2640

aaatggaaaa agtgatagct ttggtgattt tgtaaaagtc ataaatgctt attgtaaaaa     2700

atacaggaaa ccacccctca ccctgtccac ttgggtgatc attccagacc cctccccaaa     2760

catgcatatg tacctgtccg tcagtgtgtg gatgtatgtt tacagttcta cataaatggg     2820

atcattttat acatggtgct ctggaaccca catttttcat gcagtcattt gcagtgaatt     2880

atttattgtg ataataaata gcattagaat acaagatttt taaaaaaaaa                2930


<210>  5
<211>  1999
<212>  DNA
<213>  Rattus norvegicus

<400>  5
atgtactgcc cactctgttc ctgagattcc tgaggactca gctacggcca cttcggagga       60

ccccgagcct cggcgttcgg tggctttgta aaaggtctgg gtcaggccag atccccccag      120

cctgatcatg gcaccagaca cacactgctg ctccagggca gacctgagga ggaggctacc      180

cgtcctggcc tggctgccca actactctct gcggtggctg agaatggacg tcatcgctgg      240

actctccgtg ggtctcaccg tcatccccca ggccctggcc tatgcagaag tggctggact      300

cccgccccag tacggtctct actctgcctt catggggtgc ttcgtgtact tcgtcctggg      360

cacctcccgg gatgtgactc tgggccccac ggctatcatg tctctcctgg tatcctacta      420

caccttccgt gagcctgcct atgccgtgct gcttgccttc ctgtctgggt gtatccagtt      480

ggccatgggg ctcctgcatt tggggttcct gctggacttc atctcctgcc ctgtcattaa      540

aggcttcaca tccgctgcca gcatcacaat tggctttgga caggtcaaga acctgctggg      600

attacagaac atcccccggc agttcttcct ccaggtgtac cacaccttcc tccacatcgg      660

agagaccagg gtgggcgatg ccatcctggg actggtctgc atggtgctgc tgcttgtgct      720

gaagcttatg cgtgaacaca ttcctcctcc ccatcctgag atgccccttg gcgtgaagtt      780

cagccgtggg ctagtgtgga ccgtcacaac agctcgcaac gccttggtgg tctccttcgc      840

ggccctgatt gcttacgcct tcgaggtgac aggatcccat ccgttcattc tgactggaaa      900

gatcgcccag gggctccctc ctgtgaggat gccgcccttc tcagtgacca cagacaataa      960

gaccatctct ttctctgaga tggtgcagga catgggggtc ggactggctg tggtgcctct     1020

gatgggcctc ctggagacca ttgctgtggc caaatccttc gcctcccaga ataattaccg     1080

cattgatgcc aaccaggagc tgctggccat cggcctcacc aatgtgctgg gctccctagt     1140

ctcgtcttac ccggtcactg gcagctttgg gcggacagca gtgaatgccc agacgggggt     1200

gtgtaccccg gcaggaggcc tggtgactgg tgtcctggtg ctgctgtctc tggactacct     1260

gaccttactg ttctactata tccccaagtc tgcactggct gccgtcatca tcatggctgt     1320

ggccccgctc tttgacgtca agatcttcag gaggctctgg cttgttcaga gtacgtaccg     1380

caaagcaggc agctctgggg tgacatctgg gaatgcctag gcctttgtta tccctcctgg     1440

cctgtgggct ggagctgtgg cactctggta aacttaggag aagatacact ggaggtggct     1500

gcttagcgag cgaagctgga cttcggtcca cacagagctg gacagagctc tgtagctttg     1560

gagtggagag cagagtttcc ccactcggtg tcctcatcct ctcctccccc catctttctc     1620

ttcctgaggg ggtggtgaca gaaaggcctc acacaatagt ctctcagtct cccccatctc     1680

ccgccctgag agcccctcat ccactggttt ctttaacaaa tcagaggtta acttttcctc     1740

cttcctcgtt gtccagttgt cgggtgtgtg tcccagcttt ctgtgtacca ggtttcatct     1800

ttaggacagc cttgagatat atcagtgtag atgtgtggaa ctgatgttct ccaaggaaac     1860

taggactcca gaaagggcat ggcctgtcta ggttgccaca tcagaggtac aatctcagac     1920

tgagtccaag tactttgtgc ccagggcaat aaatcctcct ggtctcctgg agtcacaaga     1980

cacaccacac acgcaccat                                                  1999


<210>  6
<211>  2692
<212>  DNA
<213>  Mus musculus

<400>  6
atgtcctgcc cactctgttt ctgagattcc tgcggactca gctaccgcca cttcggaaga       60

ccctgagtct cagcgtccgc tctgtgaaag gtctgggtca gaccagatcc cccagcctgc      120

acatggcacc agacacatgc tgctgctctg ctacggccct gaggaggagg ctacccgtcc      180

tggcctgggt gcctgactac tctctgcagt ggctgaggct ggacttcatc gctggacttt      240

ccgtgggact caccgtcatt ccccaggccc tggcctatgc agaagtggct ggactcccac      300

cccagtacgg cctctactct gccttcatgg gatgcttcgt gtatttcttc ctgggcacct      360

cccgggatgt gactctgggc cccacggcta tcatgtctct cctggtgtcc ttctacacct      420

tccgtgagcc tgcctatgct gtgctgcttg ccttcctgtc tgggtgtatc cagctggcca      480

tggggctcct gcatttgggg ttcctgctgg acttcatctc ctgccctgtc attaaaggct      540

tcacctccgc tgccagcatc acaattggct ttggacagat caagaacctg ctgggattgc      600

agaaaatccc ccggcagttc ttcctccagg tgtaccacac cttcctccac atcggagaga      660

ccagggtagg cgacgctgtc ctcggactgg cctccatgtt gctgctgctt gtgctgaagt      720

gtatgcggga acacatgcct cctccccatc ctgagatgcc ccttgccgtg aagttcagcc      780

gtgggctggt gtggactgtc acaacagctc gcaatgccct ggtggtctcc tccgcggctc      840

tgattgctta cgccttcgag gtgacaggat cccatccctt tgttctgact ggaaagatcg      900

ccgaggggct ccctccggtg cggatcccac ccttctcagt gaccagggac aataagacca      960

tctcgttctc tgagatggtg caggacatgg gggccggact ggctgtggta cctctgatgg     1020

ggctcctgga gagcattgcc gtggccaaat ccttcgcgtc tcagaataac taccgcattg     1080

atgctaacca ggaactactg gccattggcc tcaccaatgt gctgggctcc ctcgtctcct     1140

cttacccagt cactggcagc tttgggcgga cagctgtgaa tgcccagaca ggggtgtgta     1200

ccccggcagg aggcctggtg actggtgccc tggtgctgct gtccctgaac tacttgacct     1260

cactcttctc ctatatcccc aagtctgccc tggctgccgt gatcatcacg gctgtgaccc     1320

cactctttga tgtcaagatc ttcaggagtc tctggcgcgt tcagaggctg gatctgctac     1380

cactgtgtgt gacgttcctg ctgtccttct gggagatcca gtacggtatc ctggccggta     1440

gcctggtgtc tttgctcatt ctcctgcact cggtagctag gcccaagact caggtgtcag     1500

aaggacaaat ttttgttctt cagccggcca gcggcctgta cttccctgca attgatgccc     1560

tccgagaggc aataacgaac cgggcactgg aagcatcccc accacgttcc gcggttctgg     1620

agtgcacgca tatcagcagt gtagactaca ccgtgatcgt gggactcggt gagctcctgg     1680

aggacttcca gaagaaagga gtcgccctgg cctttgttgg cctacaggtg cccgtgctcc     1740

gcacactgtt ggccgctgac ctcaaggggt tccgttactt caccactctg gaggaggctg     1800

agaaattcct gcagcaggaa ccaggaactg agcccaacag catccatgaa gatgctgttc     1860

cagagcaaag gagctccctg ctcaagtctc cctccggccc ctgaagagca gatggtatag     1920

gaagggtttc tggaaggttc tgtcaccatg acttggagtc acctgataga ctcaccaacc     1980

tggtgggact taaaaggcac tgcataggtg gctctgggga acagcaggga gccatgtatg     2040

atttccaggg tgtcactttc ctgctgtccc ctaggtgtga gtatttgagg gctgggctga     2100

ctgaaaagtc tttcagagag agagagagag agacagagac ccagagacac acacatggct     2160

tctggcctgg tctggcaggg taaggtgaca ctctccagat cccagattct tctttggaat     2220

caggtcctac tggagaaaaa tcaaagagat tgggcatctc ggagatgtgt ctgaccatgt     2280

catgaagtct aatctgagct gaagaggtgg ccacagcatg ccacacaagg tcaattctgt     2340

ttaaaatcat gtgtttttta aatggaagtc actctggtgt ttttgtaaag caaaacaaaa     2400

acatttatgc ttactttaaa aaaaaaatcc aagaactcat gcatcctgtt cactattctc     2460

ttaactgagg tcccctgccc ggacaggtgt gtatccgtca gtgtgtgcac acggtgccgt     2520

ctgatgtgaa gacccgaatc actgtattaa ggtgctttgt aaactgtctt catgcagtca     2580

ttaattgtga attatttatt gtgatgatca atgacattaa atgcaagatt tatttacctt     2640

attaaaatac aagatttatt tattgtatta aaatacaata ttctgtgggt cc             2692


<210>  7
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA synthesized in lab

<400>  7
ggauuacucu aucacagaca ccuac                                             25


<210>  8
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA synthesized in lab

<400>  8
guaggugucu gugauagagu aauccac                                           27


<210>  9
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA synthesized in lab

<400>  9
acagcggucu uaaaguuuau cccaa                                             25


<210>  10
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA synthesized in lab

<400>  10
uugggauaaa cuuuaagacc gcuguca                                           27


<210>  11
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  siRNA synthesized in lab

<400>  11
ugcuuauaaa gcuaaagacc gcaat                                             25


<210>  12
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA synthesized in lab

<400>  12
auugcggucu uuagcuuuau aagcaac                                           27


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA synthesized in lab

<400>  13
gcaugucagc aauauagacu acacc                                             25


<210>  14
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA synthesized in lab

<400>  14
gguguagucu auauugcuga caugcgu                                           27


<210>  15
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA synthesized in lab

<400>  15
ggagauccaa uacggcaucc uggca                                             25


<210>  16
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA synthesized in lab

<400>  16
ugccaggaug ccguauugga ucuccca                                           27


