                         SEQUENCE LISTING

<110>  BIOMMUNE TECHNOLOGIES INC
       Jefferies, Wilfred Arthur
       Choi, Kyung Bok
       Stanwood, Shawna Rose
       Fenninger, Franz
       Eyford, Brett Alexander
       Munro, Lonna
       Pfeifer, Cheryl Gurine
 
<120>  Antibodies to L-Type Voltage Gated Channels and Related Methods

<130>  BIMN-005/02WO 320528-2040

<150>  US 62/115,823
<151>  2015-02-13

<150>  US 62/280,557
<151>  2016-01-19

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  Conserved mammalian extracellular domain of Cav1.4

<400>  1

Gly Pro Gly Arg Pro Gly Asp Ala Pro His Thr Gly 
1               5                   10          


<210>  2
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  Conserved mammalian extracellular domain of Cav1.3

<400>  2

Leu Thr Lys Glu Thr Glu Gly Gly Asn His Ser Ser Gly Lys Ser Gly 
1               5                   10                  15      


<210>  3
<211>  15
<212>  PRT
<213>  Unknown

<220>
<223>  Conserved mammalian extracellular domain of Cav1.2

<400>  3

Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu Gly Gly Lys Gly Ala 
1               5                   10                  15  


<210>  4
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  Conserved mammalian extracellular domain of Cav1.1

<400>  4

Pro Met Gln Ile Glu Leu Arg His Arg Glu Trp Val His 
1               5                   10              


<210>  5
<211>  1977
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Glu Ser Glu Gly Gly Lys Asp Thr Thr Pro Glu Pro Ser Pro 
1               5                   10                  15      


Ala Asn Gly Ala Gly Pro Gly Pro Glu Trp Gly Leu Cys Pro Gly Pro 
            20                  25                  30          


Pro Ala Val Glu Gly Glu Ser Ser Gly Ala Ser Gly Leu Gly Thr Pro 
        35                  40                  45              


Lys Arg Arg Asn Gln His Ser Lys His Lys Thr Val Ala Val Ala Ser 
    50                  55                  60                  


Ala Gln Arg Ser Pro Arg Ala Leu Phe Cys Leu Thr Leu Ala Asn Pro 
65                  70                  75                  80  


Leu Arg Arg Ser Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile 
                85                  90                  95      


Leu Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr 
            100                 105                 110         


Ile Pro Phe Pro Glu Asp Asp Ser Asn Thr Ala Asn His Asn Leu Glu 
        115                 120                 125             


Gln Val Glu Tyr Val Phe Leu Val Ile Phe Thr Val Glu Thr Val Leu 
    130                 135                 140                 


Lys Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg 
145                 150                 155                 160 


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
                165                 170                 175     


Ser Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His 
            180                 185                 190         


Thr Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe 
        195                 200                 205             


Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His 
    210                 215                 220                 


Ile Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile 
225                 230                 235                 240 


Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu 
                245                 250                 255     


Glu Leu Phe Leu Gly Arg Met His Lys Thr Cys Tyr Phe Leu Gly Ser 
            260                 265                 270         


Asp Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser 
        275                 280                 285             


Gly Arg Ala Cys Thr Leu Asn Gln Thr Glu Cys Arg Gly Arg Trp Pro 
    290                 295                 300                 


Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Phe Phe Ala Met 
305                 310                 315                 320 


Leu Thr Val Phe Gln Cys Val Thr Met Glu Gly Trp Thr Asp Val Leu 
                325                 330                 335     


Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe 
            340                 345                 350         


Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu 
        355                 360                 365             


Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala 
    370                 375                 380                 


Arg Gly Asp Phe Gln Lys Gln Arg Glu Lys Gln Gln Met Glu Glu Asp 
385                 390                 395                 400 


Leu Arg Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Glu Leu Asp Met 
                405                 410                 415     


Glu Asp Pro Ser Ala Asp Asp Asn Leu Gly Ser Met Ala Glu Glu Gly 
            420                 425                 430         


Arg Ala Gly His Arg Pro Gln Leu Ala Glu Leu Thr Asn Arg Arg Arg 
        435                 440                 445             


Gly Arg Leu Arg Trp Phe Ser His Ser Thr Arg Ser Thr His Ser Thr 
    450                 455                 460                 


Ser Ser His Ala Ser Leu Pro Ala Ser Asp Thr Gly Ser Met Thr Glu 
465                 470                 475                 480 


Thr Gln Gly Asp Glu Asp Glu Glu Glu Gly Ala Leu Ala Ser Cys Thr 
                485                 490                 495     


Arg Cys Leu Asn Lys Ile Met Lys Thr Arg Val Cys Arg Arg Leu Arg 
            500                 505                 510         


Arg Ala Asn Arg Val Leu Arg Ala Arg Cys Arg Arg Ala Val Lys Ser 
        515                 520                 525             


Asn Ala Cys Tyr Trp Ala Val Leu Leu Leu Val Phe Leu Asn Thr Leu 
    530                 535                 540                 


Thr Ile Ala Ser Glu His His Gly Gln Pro Val Trp Leu Thr Gln Ile 
545                 550                 555                 560 


Gln Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu Phe Thr Val Glu Met 
                565                 570                 575     


Leu Leu Lys Leu Tyr Gly Leu Gly Pro Ser Ala Tyr Val Ser Ser Phe 
            580                 585                 590         


Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr 
        595                 600                 605             


Thr Leu Val Glu Val Gly Ala Met Gln Pro Leu Gly Ile Ser Val Leu 
    610                 615                 620                 


Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Ala 
625                 630                 635                 640 


Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile 
                645                 650                 655     


Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu 
            660                 665                 670         


Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Gln Thr His 
        675                 680                 685             


Thr Lys Arg Ser Thr Phe Asp Thr Phe Pro Gln Ala Leu Leu Thr Val 
    690                 695                 700                 


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Val Val Met Tyr Asp Gly 
705                 710                 715                 720 


Ile Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly Met Leu Val Cys Ile 
                725                 730                 735     


Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val 
            740                 745                 750         


Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Ser Gly Asp Ala Gly Thr 
        755                 760                 765             


Ala Lys Asp Lys Gly Gly Glu Lys Ser Asn Glu Lys Asp Leu Pro Gln 
    770                 775                 780                 


Glu Asn Glu Gly Leu Val Pro Gly Val Glu Lys Glu Glu Glu Glu Gly 
785                 790                 795                 800 


Ala Arg Arg Glu Gly Ala Asp Met Glu Glu Glu Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Glu Glu Glu Glu Glu Glu Glu Gly Ala Gly Gly Val Glu Leu 
            820                 825                 830         


Leu Gln Glu Val Val Pro Lys Glu Lys Val Val Pro Ile Pro Glu Gly 
        835                 840                 845             


Ser Ala Phe Phe Cys Leu Ser Gln Thr Asn Pro Leu Arg Lys Gly Cys 
    850                 855                 860                 


His Thr Leu Ile His His His Val Phe Thr Asn Leu Ile Leu Val Phe 
865                 870                 875                 880 


Ile Ile Leu Ser Ser Val Ser Leu Ala Ala Glu Asp Pro Ile Arg Ala 
                885                 890                 895     


His Ser Phe Arg Asn His Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr 
            900                 905                 910         


Ser Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Val Phe Gly Ala 
        915                 920                 925             


Phe Leu His Arg Gly Ser Phe Cys Arg Ser Trp Phe Asn Met Leu Asp 
    930                 935                 940                 


Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile His Ser Ser 
945                 950                 955                 960 


Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro 
                965                 970                 975     


Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val Val Gln Cys 
            980                 985                 990         


Val Phe Val Ala Ile Arg Thr Ile  Gly Asn Ile Met Ile  Val Thr Thr 
        995                 1000                 1005             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1010                 1015                 1020             


Gly Lys  Phe Tyr Thr Cys Thr  Asp Glu Ala Lys His  Thr Pro Gln 
    1025                 1030                 1035             


Glu Cys  Lys Gly Ser Phe Leu  Val Tyr Pro Asp Gly  Asp Val Ser 
    1040                 1045                 1050             


Arg Pro  Leu Val Arg Glu Arg  Leu Trp Val Asn Ser  Asp Phe Asn 
    1055                 1060                 1065             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1070                 1075                 1080             


Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ala 
    1085                 1090                 1095             


Tyr Ala  Glu Asp His Gly Pro  Ile Tyr Asn Tyr Arg  Val Glu Ile 
    1100                 1105                 1110             


Ser Val  Phe Phe Ile Val Tyr  Ile Ile Ile Ile Ala  Phe Phe Met 
    1115                 1120                 1125             


Met Asn  Ile Phe Val Gly Phe  Val Ile Ile Thr Phe  Arg Ala Gln 
    1130                 1135                 1140             


Gly Glu  Gln Glu Tyr Gln Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1145                 1150                 1155             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Gln Pro Leu  Arg Arg Tyr 
    1160                 1165                 1170             


Ile Pro  Lys Asn Pro His Gln  Tyr Arg Val Trp Ala  Thr Val Asn 
    1175                 1180                 1185             


Ser Ala  Ala Phe Glu Tyr Leu  Met Phe Leu Leu Ile  Leu Leu Asn 
    1190                 1195                 1200             


Thr Val  Ala Leu Ala Met Gln  His Tyr Glu Gln Thr  Ala Pro Phe 
    1205                 1210                 1215             


Asn Tyr  Ala Met Asp Ile Leu  Asn Met Val Phe Thr  Gly Leu Phe 
    1220                 1225                 1230             


Thr Ile  Glu Met Val Leu Lys  Ile Ile Ala Phe Lys  Pro Lys His 
    1235                 1240                 1245             


Tyr Phe  Thr Asp Ala Trp Asn  Thr Phe Asp Ala Leu  Ile Val Val 
    1250                 1255                 1260             


Gly Ser  Ile Val Asp Ile Ala  Val Thr Glu Val Asn  Asn Gly Gly 
    1265                 1270                 1275             


His Leu  Gly Glu Ser Ser Glu  Asp Ser Ser Arg Ile  Ser Ile Thr 
    1280                 1285                 1290             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Val Lys  Leu Leu Ser 
    1295                 1300                 1305             


Lys Gly  Glu Gly Ile Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1310                 1315                 1320             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Ala  Met Ile Phe 
    1325                 1330                 1335             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Val Ala 
    1340                 1345                 1350             


Leu Gln  Asp Gly Thr Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1355                 1360                 1365             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1370                 1375                 1380             


Ala Trp  Gln Glu Ile Met Leu  Ala Ser Leu Pro Gly  Asn Arg Cys 
    1385                 1390                 1395             


Asp Pro  Glu Ser Asp Phe Gly  Pro Gly Glu Glu Phe  Thr Cys Gly 
    1400                 1405                 1410             


Ser Asn  Phe Ala Ile Ala Tyr  Phe Ile Ser Phe Phe  Met Leu Cys 
    1415                 1420                 1425             


Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1430                 1435                 1440             


Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1445                 1450                 1455             


Leu Asp  Glu Phe Lys Arg Ile  Trp Ser Glu Tyr Asp  Pro Gly Ala 
    1460                 1465                 1470             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Ala Leu  Leu Arg Arg 
    1475                 1480                 1485             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu Cys Pro  His Arg Val 
    1490                 1495                 1500             


Ala Cys  Lys Arg Leu Val Ala  Met Asn Met Pro Leu  Asn Ser Asp 
    1505                 1510                 1515             


Gly Thr  Val Thr Phe Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr 
    1520                 1525                 1530             


Ser Leu  Lys Ile Lys Thr Glu  Gly Asn Leu Glu Gln  Ala Asn Gln 
    1535                 1540                 1545             


Glu Leu  Arg Ile Val Ile Lys  Lys Ile Trp Lys Arg  Met Lys Gln 
    1550                 1555                 1560             


Lys Leu  Leu Asp Glu Val Ile  Pro Pro Pro Asp Glu  Glu Glu Val 
    1565                 1570                 1575             


Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu Ile Gln  Asp Tyr Phe 
    1580                 1585                 1590             


Arg Lys  Phe Arg Arg Arg Lys  Glu Lys Gly Leu Leu  Gly Asn Asp 
    1595                 1600                 1605             


Ala Ala  Pro Ser Thr Ser Ser  Ala Leu Gln Ala Gly  Leu Arg Ser 
    1610                 1615                 1620             


Leu Gln  Asp Leu Gly Pro Glu  Met Arg Gln Ala Leu  Thr Cys Asp 
    1625                 1630                 1635             


Thr Glu  Glu Glu Glu Glu Glu  Gly Gln Glu Gly Val  Glu Glu Glu 
    1640                 1645                 1650             


Asp Glu  Lys Asp Leu Glu Thr  Asn Lys Ala Thr Met  Val Ser Gln 
    1655                 1660                 1665             


Pro Ser  Ala Arg Arg Gly Ser  Gly Ile Ser Val Ser  Leu Pro Val 
    1670                 1675                 1680             


Gly Asp  Arg Leu Pro Asp Ser  Leu Ser Phe Gly Pro  Ser Asp Asp 
    1685                 1690                 1695             


Asp Arg  Gly Thr Pro Thr Ser  Ser Gln Pro Ser Val  Pro Gln Ala 
    1700                 1705                 1710             


Gly Ser  Asn Thr His Arg Arg  Gly Ser Gly Ala Leu  Ile Phe Thr 
    1715                 1720                 1725             


Ile Pro  Glu Glu Gly Asn Ser  Gln Pro Lys Gly Thr  Lys Gly Gln 
    1730                 1735                 1740             


Asn Lys  Gln Asp Glu Asp Glu  Glu Val Pro Asp Arg  Leu Ser Tyr 
    1745                 1750                 1755             


Leu Asp  Glu Gln Ala Gly Thr  Pro Pro Cys Ser Val  Leu Leu Pro 
    1760                 1765                 1770             


Pro His  Arg Ala Gln Arg Tyr  Met Asp Gly His Leu  Val Pro Arg 
    1775                 1780                 1785             


Arg Arg  Leu Leu Pro Pro Thr  Pro Ala Gly Arg Lys  Pro Ser Phe 
    1790                 1795                 1800             


Thr Ile  Gln Cys Leu Gln Arg  Gln Gly Ser Cys Glu  Asp Leu Pro 
    1805                 1810                 1815             


Ile Pro  Gly Thr Tyr His Arg  Gly Arg Asn Ser Gly  Pro Asn Arg 
    1820                 1825                 1830             


Ala Gln  Gly Ser Trp Ala Thr  Pro Pro Gln Arg Gly  Arg Leu Leu 
    1835                 1840                 1845             


Tyr Ala  Pro Leu Leu Leu Val  Glu Glu Gly Ala Ala  Gly Glu Gly 
    1850                 1855                 1860             


Tyr Leu  Gly Arg Ser Ser Gly  Pro Leu Arg Thr Phe  Thr Cys Leu 
    1865                 1870                 1875             


His Val  Pro Gly Thr His Ser  Asp Pro Ser His Gly  Lys Arg Gly 
    1880                 1885                 1890             


Ser Ala  Asp Ser Leu Val Glu  Ala Val Leu Ile Ser  Glu Gly Leu 
    1895                 1900                 1905             


Gly Leu  Phe Ala Arg Asp Pro  Arg Phe Val Ala Leu  Ala Lys Gln 
    1910                 1915                 1920             


Glu Ile  Ala Asp Ala Cys Arg  Leu Thr Leu Asp Glu  Met Asp Asn 
    1925                 1930                 1935             


Ala Ala  Ser Asp Leu Leu Ala  Gln Gly Thr Ser Ser  Leu Tyr Ser 
    1940                 1945                 1950             


Asp Glu  Glu Ser Ile Leu Ser  Arg Phe Asp Glu Glu  Asp Leu Gly 
    1955                 1960                 1965             


Asp Glu  Met Ala Cys Val His  Ala Leu 
    1970                 1975         


<210>  6
<211>  2161
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Met Asn Asp Ala Met Gly Phe Glu Leu Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Cys Gln Ala Ile 
                485                 490                 495     


Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp Asn Arg Phe Asn 
            500                 505                 510         


Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr Phe Tyr Trp Leu 
        515                 520                 525             


Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile Ser Ser Glu His 
    530                 535                 540                 


Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp Ile Ala Asn Lys 
545                 550                 555                 560 


Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val Lys Met Tyr Ser 
                565                 570                 575     


Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp Cys 
            580                 585                 590         


Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu Val Glu Leu Glu 
        595                 600                 605             


Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys Val Arg Leu Leu 
    610                 615                 620                 


Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu Ser Asn Leu Val 
625                 630                 635                 640 


Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser Leu Leu Leu Leu 
                645                 650                 655     


Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu Phe 
            660                 665                 670         


Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys Arg Ser Thr Phe 
        675                 680                 685             


Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln Ile Leu Thr Gly 
    690                 695                 700                 


Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met Ala Tyr Gly Gly 
705                 710                 715                 720 


Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe Ile Ile Leu Phe 
                725                 730                 735     


Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala Val 
            740                 745                 750         


Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala Gln Lys Glu Glu 
        755                 760                 765             


Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys Glu Ser Leu Glu 
    770                 775                 780                 


Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile Ala Asn Ser Asp 
785                 790                 795                 800 


Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp Glu Asp Lys Asp 
                805                 810                 815     


Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu Glu Glu Glu Glu 
            820                 825                 830         


Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg Pro Arg Arg Ile 
        835                 840                 845             


Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile Pro Glu Gly Ser 
    850                 855                 860                 


Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg Val Gly Cys His 
865                 870                 875                 880 


Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile Leu Val Phe Ile 
                885                 890                 895     


Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro Ile Arg Ser His 
            900                 905                 910         


Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr Ala Phe Thr Ala 
        915                 920                 925             


Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr Phe Gly Ala Phe 
    930                 935                 940                 


Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn Leu Leu Asp Met 
945                 950                 955                 960 


Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile Gln Ser Ser Ala 
                965                 970                 975     


Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val Leu Arg Pro Leu 
            980                 985                 990         


Arg Ala Ile Asn Arg Ala Lys Gly  Leu Lys His Val Val  Gln Cys Val 
        995                 1000                 1005             


Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile Met Ile  Val Thr Thr 
    1010                 1015                 1020             


Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly Val Gln  Leu Phe Lys 
    1025                 1030                 1035             


Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala Lys Ser  Asn Pro Glu 
    1040                 1045                 1050             


Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys Asp Gly  Asp Val Asp 
    1055                 1060                 1065             


Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln Asn Ser  Asp Phe Asn 
    1070                 1075                 1080             


Phe Asp  Asn Val Leu Ser Ala  Met Met Ala Leu Phe  Thr Val Ser 
    1085                 1090                 1095             


Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr Lys Ala  Ile Asp Ser 
    1100                 1105                 1110             


Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn His Arg  Val Glu Ile 
    1115                 1120                 1125             


Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile Val Ala  Phe Phe Met 
    1130                 1135                 1140             


Met Asn  Ile Phe Val Gly Phe  Val Ile Val Thr Phe  Gln Glu Gln 
    1145                 1150                 1155             


Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu Asp Lys  Asn Gln Arg 
    1160                 1165                 1170             


Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg Pro Leu  Arg Arg Tyr 
    1175                 1180                 1185             


Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe Trp Tyr  Val Val Asn 
    1190                 1195                 1200             


Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val Leu Ile  Met Leu Asn 
    1205                 1210                 1215             


Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu Gln Ser  Lys Met Phe 
    1220                 1225                 1230             


Asn Asp  Ala Met Asp Ile Leu  Asn Met Val Phe Thr  Gly Val Phe 
    1235                 1240                 1245             


Thr Val  Glu Met Val Leu Lys  Val Ile Ala Phe Lys  Pro Lys Gly 
    1250                 1255                 1260             


Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp Ser Leu  Ile Val Ile 
    1265                 1270                 1275             


Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu Ala Asp  Pro Thr Glu 
    1280                 1285                 1290             


Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr Pro Gly  Asn Ser Glu 
    1295                 1300                 1305             


Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val 
    1310                 1315                 1320             


Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr 
    1325                 1330                 1335             


Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val 
    1340                 1345                 1350             


Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly 
    1355                 1360                 1365             


Met Gln  Met Phe Gly Lys Val  Ala Met Arg Asp Asn  Asn Gln Ile 
    1370                 1375                 1380             


Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu 
    1385                 1390                 1395             


Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp Gln Glu  Ile Met Leu 
    1400                 1405                 1410             


Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro Glu Ser  Asp Tyr Asn 
    1415                 1420                 1425             


Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn Phe Ala  Ile Val Tyr 
    1430                 1435                 1440             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1445                 1450                 1455             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1460                 1465                 1470             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1475                 1480                 1485             


Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1490                 1495                 1500             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1505                 1510                 1515             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ala 
    1520                 1525                 1530             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1535                 1540                 1545             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Lys Ile  Lys Thr Glu 
    1550                 1555                 1560             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Val Ile Lys 
    1565                 1570                 1575             


Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1580                 1585                 1590             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1595                 1600                 1605             


Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1610                 1615                 1620             


Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala Lys Asn  Thr Thr Ile 
    1625                 1630                 1635             


Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His Asp Ile  Gly Pro Glu 
    1640                 1645                 1650             


Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln Asp Asp  Glu Pro Glu 
    1655                 1660                 1665             


Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val Phe Lys  Arg Asn Gly 
    1670                 1675                 1680             


Ala Leu  Leu Gly Asn His Val  Asn His Val Asn Ser  Asp Arg Arg 
    1685                 1690                 1695             


Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His Arg Pro  Leu His Val 
    1700                 1705                 1710             


Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp Thr Glu  Lys Pro Leu 
    1715                 1720                 1725             


Phe Pro  Pro Ala Gly Asn Ser  Val Cys His Asn His  His Asn His 
    1730                 1735                 1740             


Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser Thr Asn  Ala Asn Leu 
    1745                 1750                 1755             


Asn Asn  Ala Asn Met Ser Lys  Ala Ala His Gly Lys  Arg Pro Ser 
    1760                 1765                 1770             


Ile Gly  Asn Leu Glu His Val  Ser Glu Asn Gly His  His Ser Ser 
    1775                 1780                 1785             


His Lys  His Asp Arg Glu Pro  Gln Arg Arg Ser Ser  Val Lys Arg 
    1790                 1795                 1800             


Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser Asp Ser  Gly Asp Glu 
    1805                 1810                 1815             


Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro Glu Ile  His Gly Tyr 
    1820                 1825                 1830             


Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln Glu Tyr  Phe Ser Ser 
    1835                 1840                 1845             


Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro Thr Trp  Ser Arg Gln 
    1850                 1855                 1860             


Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly Arg Asn  Ile Asp Ser 
    1865                 1870                 1875             


Glu Arg  Pro Arg Gly Tyr His  His Pro Gln Gly Phe  Leu Glu Asp 
    1880                 1885                 1890             


Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg Arg Ser  Pro Arg Arg 
    1895                 1900                 1905             


Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His Arg Arg  Ser Ser Phe 
    1910                 1915                 1920             


Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser Gln Glu  Glu Val Pro 
    1925                 1930                 1935             


Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala Leu Pro  Leu His Leu 
    1940                 1945                 1950             


Met Gln  Gln Gln Ile Met Ala  Val Ala Gly Leu Asp  Ser Ser Lys 
    1955                 1960                 1965             


Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr Arg Ser  Trp Ala Thr 
    1970                 1975                 1980             


Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp Thr Pro  Cys Tyr Thr 
    1985                 1990                 1995             


Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala Leu Asp  Gln Val Asn 
    2000                 2005                 2010             


Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser Trp Tyr  Thr Asp Glu 
    2015                 2020                 2025             


Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro Ala Ser  Leu Thr Val 
    2030                 2035                 2040             


Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp Lys Gln  Arg Ser Ala 
    2045                 2050                 2055             


Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser Glu Gly  Leu Gly Arg 
    2060                 2065                 2070             


Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala Thr Lys  His Glu Ile 
    2075                 2080                 2085             


Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu Met Glu  Ser Ala Ala 
    2090                 2095                 2100             


Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro Arg Ala  Asn Gly Asp 
    2105                 2110                 2115             


Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr Glu Leu  Gln Asp Phe 
    2120                 2125                 2130             


Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp Pro Gly  Arg Asp Glu 
    2135                 2140                 2145             


Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile Thr Thr  Leu 
    2150                 2155                 2160     


<210>  7
<211>  2221
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Asn Glu Asn Thr Arg Met Tyr Ile Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Ser Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ala Asp Val Pro Ala Glu Asp Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Val Asn Asp Ala Val Gly Arg Asp Trp Pro Trp Ile Tyr 
    370                 375                 380                 


Phe Val Thr Leu Ile Ile Ile Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Glu Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro Asn Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Leu Val Glu Lys Pro Ala Val Gly Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Ala Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Asn Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro Tyr Pro Asn Pro Glu Thr Thr Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Ser Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Phe Tyr Phe Asp Ile Val Phe Thr Thr Ile Phe 
    930                 935                 940                 


Thr Ile Glu Ile Ala Leu Lys Ile Leu Gly Asn Ala Asp Tyr Val Phe 
945                 950                 955                 960 


Thr Ser Ile Phe Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly 
                965                 970                 975     


Ala Phe Leu His Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu 
            980                 985                 990         


Asp Leu Leu Val Val Ser Val Ser  Leu Ile Ser Phe Gly  Ile Gln Ser 
        995                 1000                 1005             


Ser Ala  Ile Asn Val Val Lys  Ile Leu Arg Val Leu  Arg Val Leu 
    1010                 1015                 1020             


Arg Pro  Leu Arg Ala Ile Asn  Arg Ala Lys Gly Leu  Lys His Val 
    1025                 1030                 1035             


Val Gln  Cys Val Phe Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val 
    1040                 1045                 1050             


Ile Val  Thr Thr Leu Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val 
    1055                 1060                 1065             


Gln Leu  Phe Lys Gly Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys 
    1070                 1075                 1080             


Gln Thr  Glu Ala Glu Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp 
    1085                 1090                 1095             


Gly Glu  Val Asp His Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn 
    1100                 1105                 1110             


Ser Lys  Phe Asp Phe Asp Asn  Val Leu Ala Ala Met  Met Ala Leu 
    1115                 1120                 1125             


Phe Thr  Val Ser Thr Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg 
    1130                 1135                 1140             


Ser Ile  Asp Ser His Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr 
    1145                 1150                 1155             


Arg Val  Glu Ile Ser Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile 
    1160                 1165                 1170             


Ala Phe  Phe Met Met Asn Ile  Phe Val Gly Phe Val  Ile Val Thr 
    1175                 1180                 1185             


Phe Gln  Glu Gln Gly Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp 
    1190                 1195                 1200             


Lys Asn  Gln Arg Gln Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro 
    1205                 1210                 1215             


Leu Arg  Arg Tyr Ile Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp 
    1220                 1225                 1230             


Tyr Val  Val Asn Ser Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu 
    1235                 1240                 1245             


Ile Leu  Leu Asn Thr Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln 
    1250                 1255                 1260             


Ser Cys  Leu Phe Lys Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe 
    1265                 1270                 1275             


Thr Gly  Leu Phe Thr Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe 
    1280                 1285                 1290             


Lys Pro  Lys Gly Tyr Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe 
    1295                 1300                 1305             


Leu Ile  Val Ile Gly Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr 
    1310                 1315                 1320             


Asn His  Tyr Phe Cys Asp Ala  Trp Asn Thr Phe Asp  Ala Leu Ile 
    1325                 1330                 1335             


Val Val  Gly Ser Ile Val Asp  Ile Ala Ile Thr Glu  Val Asn Pro 
    1340                 1345                 1350             


Ala Glu  His Thr Gln Cys Ser  Pro Ser Met Asn Ala  Glu Glu Asn 
    1355                 1360                 1365             


Ser Arg  Ile Ser Ile Thr Phe  Phe Arg Leu Phe Arg  Val Met Arg 
    1370                 1375                 1380             


Leu Val  Lys Leu Leu Ser Arg  Gly Glu Gly Ile Arg  Thr Leu Leu 
    1385                 1390                 1395             


Trp Thr  Phe Ile Lys Ser Phe  Gln Ala Leu Pro Tyr  Val Ala Leu 
    1400                 1405                 1410             


Leu Ile  Val Met Leu Phe Phe  Ile Tyr Ala Val Ile  Gly Met Gln 
    1415                 1420                 1425             


Val Phe  Gly Lys Ile Ala Leu  Asn Asp Thr Thr Glu  Ile Asn Arg 
    1430                 1435                 1440             


Asn Asn  Asn Phe Gln Thr Phe  Pro Gln Ala Val Leu  Leu Leu Phe 
    1445                 1450                 1455             


Arg Cys  Ala Thr Gly Glu Ala  Trp Gln Asp Ile Met  Leu Ala Cys 
    1460                 1465                 1470             


Met Pro  Gly Lys Lys Cys Ala  Pro Glu Ser Glu Pro  Ser Asn Ser 
    1475                 1480                 1485             


Thr Glu  Gly Glu Thr Pro Cys  Gly Ser Ser Phe Ala  Val Phe Tyr 
    1490                 1495                 1500             


Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu 
    1505                 1510                 1515             


Phe Val  Ala Val Ile Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp 
    1520                 1525                 1530             


Trp Ser  Ile Leu Gly Pro His  His Leu Asp Glu Phe  Lys Arg Ile 
    1535                 1540                 1545             


Trp Ala  Glu Tyr Asp Pro Glu  Ala Lys Gly Arg Ile  Lys His Leu 
    1550                 1555                 1560             


Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe 
    1565                 1570                 1575             


Gly Lys  Leu Cys Pro His Arg  Val Ala Cys Lys Arg  Leu Val Ser 
    1580                 1585                 1590             


Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr Val Met  Phe Asn Ala 
    1595                 1600                 1605             


Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu Arg Ile  Lys Thr Glu 
    1610                 1615                 1620             


Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu Arg Ala  Ile Ile Lys 
    1625                 1630                 1635             


Lys Ile  Trp Lys Arg Thr Ser  Met Lys Leu Leu Asp  Gln Val Val 
    1640                 1645                 1650             


Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val Gly Lys  Phe Tyr Ala 
    1655                 1660                 1665             


Thr Phe  Leu Ile Gln Glu Tyr  Phe Arg Lys Phe Lys  Lys Arg Lys 
    1670                 1675                 1680             


Glu Gln  Gly Leu Val Gly Lys  Pro Ser Gln Arg Asn  Ala Leu Ser 
    1685                 1690                 1695             


Leu Gln  Ala Gly Leu Arg Thr  Leu His Asp Ile Gly  Pro Glu Ile 
    1700                 1705                 1710             


Arg Arg  Ala Ile Ser Gly Asp  Leu Thr Ala Glu Glu  Glu Leu Asp 
    1715                 1720                 1725             


Lys Ala  Met Lys Glu Ala Val  Ser Ala Ala Ser Glu  Asp Asp Ile 
    1730                 1735                 1740             


Phe Arg  Arg Ala Gly Gly Leu  Phe Gly Asn His Val  Ser Tyr Tyr 
    1745                 1750                 1755             


Gln Ser  Asp Gly Arg Ser Ala  Phe Pro Gln Thr Phe  Thr Thr Gln 
    1760                 1765                 1770             


Arg Pro  Leu His Ile Asn Lys  Ala Gly Ser Ser Gln  Gly Asp Thr 
    1775                 1780                 1785             


Glu Ser  Pro Ser His Glu Lys  Leu Val Asp Ser Thr  Phe Thr Pro 
    1790                 1795                 1800             


Ser Ser  Tyr Ser Ser Thr Gly  Ser Asn Ala Asn Ile  Asn Asn Ala 
    1805                 1810                 1815             


Asn Asn  Thr Ala Leu Gly Arg  Leu Pro Arg Pro Ala  Gly Tyr Pro 
    1820                 1825                 1830             


Ser Thr  Val Ser Thr Val Glu  Gly His Gly Pro Pro  Leu Ser Pro 
    1835                 1840                 1845             


Ala Ile  Arg Val Gln Glu Val  Ala Trp Lys Leu Ser  Ser Asn Arg 
    1850                 1855                 1860             


Glu Arg  His Val Pro Met Cys  Glu Asp Leu Glu Leu  Arg Arg Asp 
    1865                 1870                 1875             


Ser Gly  Ser Ala Gly Thr Gln  Ala His Cys Leu Leu  Leu Arg Arg 
    1880                 1885                 1890             


Ala Asn  Pro Ser Arg Cys His  Ser Arg Glu Ser Gln  Ala Ala Met 
    1895                 1900                 1905             


Ala Gly  Gln Glu Glu Thr Ser  Gln Asp Glu Thr Tyr  Glu Val Lys 
    1910                 1915                 1920             


Met Asn  His Asp Thr Glu Ala  Cys Ser Glu Pro Ser  Leu Leu Ser 
    1925                 1930                 1935             


Thr Glu  Met Leu Ser Tyr Gln  Asp Asp Glu Asn Arg  Gln Leu Thr 
    1940                 1945                 1950             


Leu Pro  Glu Glu Asp Lys Arg  Asp Ile Arg Gln Ser  Pro Lys Arg 
    1955                 1960                 1965             


Gly Phe  Leu Arg Ser Ala Ser  Leu Gly Arg Arg Ala  Ser Phe His 
    1970                 1975                 1980             


Leu Glu  Cys Leu Lys Arg Gln  Lys Asp Arg Gly Gly  Asp Ile Ser 
    1985                 1990                 1995             


Gln Lys  Thr Val Leu Pro Leu  His Leu Val His His  Gln Ala Leu 
    2000                 2005                 2010             


Ala Val  Ala Gly Leu Ser Pro  Leu Leu Gln Arg Ser  His Ser Pro 
    2015                 2020                 2025             


Ala Ser  Phe Pro Arg Pro Phe  Ala Thr Pro Pro Ala  Thr Pro Gly 
    2030                 2035                 2040             


Ser Arg  Gly Trp Pro Pro Gln  Pro Val Pro Thr Leu  Arg Leu Glu 
    2045                 2050                 2055             


Gly Val  Glu Ser Ser Glu Lys  Leu Asn Ser Ser Phe  Pro Ser Ile 
    2060                 2065                 2070             


His Cys  Gly Ser Trp Ala Glu  Thr Thr Pro Gly Gly  Gly Gly Ser 
    2075                 2080                 2085             


Ser Ala  Ala Arg Arg Val Arg  Pro Val Ser Leu Met  Val Pro Ser 
    2090                 2095                 2100             


Gln Ala  Gly Ala Pro Gly Arg  Gln Phe His Gly Ser  Ala Ser Ser 
    2105                 2110                 2115             


Leu Val  Glu Ala Val Leu Ile  Ser Glu Gly Leu Gly  Gln Phe Ala 
    2120                 2125                 2130             


Gln Asp  Pro Lys Phe Ile Glu  Val Thr Thr Gln Glu  Leu Ala Asp 
    2135                 2140                 2145             


Ala Cys  Asp Met Thr Ile Glu  Glu Met Glu Ser Ala  Ala Asp Asn 
    2150                 2155                 2160             


Ile Leu  Ser Gly Gly Ala Pro  Gln Ser Pro Asn Gly  Ala Leu Leu 
    2165                 2170                 2175             


Pro Phe  Val Asn Cys Arg Asp  Ala Gly Gln Asp Arg  Ala Gly Gly 
    2180                 2185                 2190             


Glu Glu  Asp Ala Gly Cys Val  Arg Ala Arg Gly Arg  Pro Ser Glu 
    2195                 2200                 2205             


Glu Glu  Leu Gln Asp Ser Arg  Val Tyr Val Ser Ser  Leu 
    2210                 2215                 2220     


<210>  8
<211>  1873
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Pro Ser Ser Pro Gln Asp Glu Gly Leu Arg Lys Lys Gln Pro 
1               5                   10                  15      


Lys Lys Pro Val Pro Glu Ile Leu Pro Arg Pro Pro Arg Ala Leu Phe 
            20                  25                  30          


Cys Leu Thr Leu Glu Asn Pro Leu Arg Lys Ala Cys Ile Ser Ile Val 
        35                  40                  45              


Glu Trp Lys Pro Phe Glu Thr Ile Ile Leu Leu Thr Ile Phe Ala Asn 
    50                  55                  60                  


Cys Val Ala Leu Ala Val Tyr Leu Pro Met Pro Glu Asp Asp Asn Asn 
65                  70                  75                  80  


Ser Leu Asn Leu Gly Leu Glu Lys Leu Glu Tyr Phe Phe Leu Ile Val 
                85                  90                  95      


Phe Ser Ile Glu Ala Ala Met Lys Ile Ile Ala Tyr Gly Phe Leu Phe 
            100                 105                 110         


His Gln Asp Ala Tyr Leu Arg Ser Gly Trp Asn Val Leu Asp Phe Thr 
        115                 120                 125             


Ile Val Phe Leu Gly Val Phe Thr Val Ile Leu Glu Gln Val Asn Val 
    130                 135                 140                 


Ile Gln Ser His Thr Ala Pro Met Ser Ser Lys Gly Ala Gly Leu Asp 
145                 150                 155                 160 


Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val 
                165                 170                 175     


Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser Ile Phe Lys Ala 
            180                 185                 190         


Met Leu Pro Leu Phe His Ile Ala Leu Leu Val Leu Phe Met Val Ile 
        195                 200                 205             


Ile Tyr Ala Ile Ile Gly Leu Glu Leu Phe Lys Gly Lys Met His Lys 
    210                 215                 220                 


Thr Cys Tyr Phe Ile Gly Thr Asp Ile Val Ala Thr Val Glu Asn Glu 
225                 230                 235                 240 


Glu Pro Ser Pro Cys Ala Arg Thr Gly Ser Gly Arg Arg Cys Thr Ile 
                245                 250                 255     


Asn Gly Ser Glu Cys Arg Gly Gly Trp Pro Gly Pro Asn His Gly Ile 
            260                 265                 270         


Thr His Phe Asp Asn Phe Gly Phe Ser Met Leu Thr Val Tyr Gln Cys 
        275                 280                 285             


Ile Thr Met Glu Gly Trp Thr Asp Val Leu Tyr Trp Val Asn Asp Ala 
    290                 295                 300                 


Ile Gly Asn Glu Trp Pro Trp Ile Tyr Phe Val Thr Leu Ile Leu Leu 
305                 310                 315                 320 


Gly Ser Phe Phe Ile Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu 
                325                 330                 335     


Phe Thr Lys Glu Arg Glu Lys Ala Lys Ser Arg Gly Thr Phe Gln Lys 
            340                 345                 350         


Leu Arg Glu Lys Gln Gln Leu Asp Glu Asp Leu Arg Gly Tyr Met Ser 
        355                 360                 365             


Trp Ile Thr Gln Gly Glu Val Met Asp Val Glu Asp Phe Arg Glu Gly 
    370                 375                 380                 


Lys Leu Ser Leu Asp Glu Gly Gly Ser Asp Thr Glu Ser Leu Tyr Glu 
385                 390                 395                 400 


Ile Ala Gly Leu Asn Lys Ile Ile Gln Phe Ile Arg His Trp Arg Gln 
                405                 410                 415     


Trp Asn Arg Ile Phe Arg Trp Lys Cys His Asp Ile Val Lys Ser Lys 
            420                 425                 430         


Val Phe Tyr Trp Leu Val Ile Leu Ile Val Ala Leu Asn Thr Leu Ser 
        435                 440                 445             


Ile Ala Ser Glu His His Asn Gln Pro Leu Trp Leu Thr Arg Leu Gln 
    450                 455                 460                 


Asp Ile Ala Asn Arg Val Leu Leu Ser Leu Phe Thr Thr Glu Met Leu 
465                 470                 475                 480 


Met Lys Met Tyr Gly Leu Gly Leu Arg Gln Tyr Phe Met Ser Ile Phe 
                485                 490                 495     


Asn Arg Phe Asp Cys Phe Val Val Cys Ser Gly Ile Leu Glu Ile Leu 
            500                 505                 510         


Leu Val Glu Ser Gly Ala Met Thr Pro Leu Gly Ile Ser Val Leu Arg 
        515                 520                 525             


Cys Ile Arg Leu Leu Arg Ile Phe Lys Ile Thr Lys Tyr Trp Thr Ser 
    530                 535                 540                 


Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Ile Arg Ser Ile Ala 
545                 550                 555                 560 


Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Val Ile Phe Ala Leu Leu 
                565                 570                 575     


Gly Met Gln Leu Phe Gly Gly Arg Tyr Asp Phe Glu Asp Thr Glu Val 
            580                 585                 590         


Arg Arg Ser Asn Phe Asp Asn Phe Pro Gln Ala Leu Ile Ser Val Phe 
        595                 600                 605             


Gln Val Leu Thr Gly Glu Asp Trp Thr Ser Met Met Tyr Asn Gly Ile 
    610                 615                 620                 


Met Ala Tyr Gly Gly Pro Ser Tyr Pro Gly Met Leu Val Cys Ile Tyr 
625                 630                 635                 640 


Phe Ile Ile Leu Phe Val Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe 
                645                 650                 655     


Leu Ala Ile Ala Val Asp Asn Leu Ala Glu Ala Glu Ser Leu Thr Ser 
            660                 665                 670         


Ala Gln Lys Ala Lys Ala Glu Glu Lys Lys Arg Arg Lys Met Ser Lys 
        675                 680                 685             


Gly Leu Pro Asp Lys Ser Glu Glu Glu Lys Ser Thr Met Ala Lys Lys 
    690                 695                 700                 


Leu Glu Gln Lys Pro Lys Gly Glu Gly Ile Pro Thr Thr Ala Lys Leu 
705                 710                 715                 720 


Lys Ile Asp Glu Phe Glu Ser Asn Val Asn Glu Val Lys Asp Pro Tyr 
                725                 730                 735     


Pro Ser Ala Asp Phe Pro Gly Asp Asp Glu Glu Asp Glu Pro Glu Ile 
            740                 745                 750         


Pro Leu Ser Pro Arg Pro Arg Pro Leu Ala Glu Leu Gln Leu Lys Glu 
        755                 760                 765             


Lys Ala Val Pro Ile Pro Glu Ala Ser Ser Phe Phe Ile Phe Ser Pro 
    770                 775                 780                 


Thr Asn Lys Ile Arg Val Leu Cys His Arg Ile Val Asn Ala Thr Trp 
785                 790                 795                 800 


Phe Thr Asn Phe Ile Leu Leu Phe Ile Leu Leu Ser Ser Ala Ala Leu 
                805                 810                 815     


Ala Ala Glu Asp Pro Ile Arg Ala Asp Ser Met Arg Asn Gln Ile Leu 
            820                 825                 830         


Lys His Phe Asp Ile Gly Phe Thr Ser Val Phe Thr Val Glu Ile Val 
        835                 840                 845             


Leu Lys Met Thr Thr Tyr Gly Ala Phe Leu His Lys Gly Ser Phe Cys 
    850                 855                 860                 


Arg Asn Tyr Phe Asn Met Leu Asp Leu Leu Val Val Ala Val Ser Leu 
865                 870                 875                 880 


Ile Ser Met Gly Leu Glu Ser Ser Ala Ile Ser Val Val Lys Ile Leu 
                885                 890                 895     


Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys 
            900                 905                 910         


Gly Leu Lys His Val Val Gln Cys Met Phe Val Ala Ile Ser Thr Ile 
        915                 920                 925             


Gly Asn Ile Val Leu Val Thr Thr Leu Leu Gln Phe Met Phe Ala Cys 
    930                 935                 940                 


Ile Gly Val Gln Leu Phe Lys Gly Lys Phe Phe Arg Cys Thr Asp Leu 
945                 950                 955                 960 


Ser Lys Met Thr Glu Glu Glu Cys Arg Gly Tyr Tyr Tyr Val Tyr Lys 
                965                 970                 975     


Asp Gly Asp Pro Met Gln Ile Glu Leu Arg His Arg Glu Trp Val His 
            980                 985                 990         


Ser Asp Phe His Phe Asp Asn Val  Leu Ser Ala Met Met  Ser Leu Phe 
        995                 1000                 1005             


Thr Val  Ser Thr Phe Glu Gly  Trp Pro Gln Leu Leu  Tyr Lys Ala 
    1010                 1015                 1020             


Ile Asp  Ser Asn Ala Glu Asp  Val Gly Pro Ile Tyr  Asn Asn Arg 
    1025                 1030                 1035             


Val Glu  Met Ala Ile Phe Phe  Ile Ile Tyr Ile Ile  Leu Ile Ala 
    1040                 1045                 1050             


Phe Phe  Met Met Asn Ile Phe  Val Gly Phe Val Ile  Val Thr Phe 
    1055                 1060                 1065             


Gln Glu  Gln Gly Glu Thr Glu  Tyr Lys Asn Cys Glu  Leu Asp Lys 
    1070                 1075                 1080             


Asn Gln  Arg Gln Cys Val Gln  Tyr Ala Leu Lys Ala  Arg Pro Leu 
    1085                 1090                 1095             


Arg Cys  Tyr Ile Pro Lys Asn  Pro Tyr Gln Tyr Gln  Val Trp Tyr 
    1100                 1105                 1110             


Ile Val  Thr Ser Ser Tyr Phe  Glu Tyr Leu Met Phe  Ala Leu Ile 
    1115                 1120                 1125             


Met Leu  Asn Thr Ile Cys Leu  Gly Met Gln His Tyr  Asn Gln Ser 
    1130                 1135                 1140             


Glu Gln  Met Asn His Ile Ser  Asp Ile Leu Asn Val  Ala Phe Thr 
    1145                 1150                 1155             


Ile Ile  Phe Thr Leu Glu Met  Ile Leu Lys Leu Met  Ala Phe Lys 
    1160                 1165                 1170             


Ala Arg  Gly Tyr Phe Gly Asp  Pro Trp Asn Val Phe  Asp Phe Leu 
    1175                 1180                 1185             


Ile Val  Ile Gly Ser Ile Ile  Asp Val Ile Leu Ser  Glu Ile Asp 
    1190                 1195                 1200             


Thr Phe  Leu Ala Ser Ser Gly  Gly Leu Tyr Cys Leu  Gly Gly Gly 
    1205                 1210                 1215             


Cys Gly  Asn Val Asp Pro Asp  Glu Ser Ala Arg Ile  Ser Ser Ala 
    1220                 1225                 1230             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Ile Lys  Leu Leu Ser 
    1235                 1240                 1245             


Arg Ala  Glu Gly Val Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1250                 1255                 1260             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Val  Met Leu Phe 
    1265                 1270                 1275             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Ile Ala 
    1280                 1285                 1290             


Leu Val  Asp Gly Thr Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1295                 1300                 1305             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1310                 1315                 1320             


Ala Trp  Gln Glu Ile Leu Leu  Ala Cys Ser Tyr Gly  Lys Leu Cys 
    1325                 1330                 1335             


Asp Pro  Glu Ser Asp Tyr Ala  Pro Gly Glu Glu Tyr  Thr Cys Gly 
    1340                 1345                 1350             


Thr Asn  Phe Ala Tyr Tyr Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys 
    1355                 1360                 1365             


Ala Phe  Leu Val Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1370                 1375                 1380             


Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1385                 1390                 1395             


Leu Asp  Glu Phe Lys Ala Ile  Trp Ala Glu Tyr Asp  Pro Glu Ala 
    1400                 1405                 1410             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Thr Leu  Leu Arg Arg 
    1415                 1420                 1425             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Phe Cys Pro  His Arg Val 
    1430                 1435                 1440             


Ala Cys  Lys Arg Leu Val Gly  Met Asn Met Pro Leu  Asn Ser Asp 
    1445                 1450                 1455             


Gly Thr  Val Thr Phe Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr 
    1460                 1465                 1470             


Ala Leu  Lys Ile Lys Thr Glu  Gly Asn Phe Glu Gln  Ala Asn Glu 
    1475                 1480                 1485             


Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp Lys Arg  Thr Ser Met 
    1490                 1495                 1500             


Lys Leu  Leu Asp Gln Val Ile  Pro Pro Ile Gly Asp  Asp Glu Val 
    1505                 1510                 1515             


Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu Ile Gln  Glu His Phe 
    1520                 1525                 1530             


Arg Lys  Phe Met Lys Arg Gln  Glu Glu Tyr Tyr Gly  Tyr Arg Pro 
    1535                 1540                 1545             


Lys Lys  Asp Ile Val Gln Ile  Gln Ala Gly Leu Arg  Thr Ile Glu 
    1550                 1555                 1560             


Glu Glu  Ala Ala Pro Glu Ile  Cys Arg Thr Val Ser  Gly Asp Leu 
    1565                 1570                 1575             


Ala Ala  Glu Glu Glu Leu Glu  Arg Ala Met Val Glu  Ala Ala Met 
    1580                 1585                 1590             


Glu Glu  Gly Ile Phe Arg Arg  Thr Gly Gly Leu Phe  Gly Gln Val 
    1595                 1600                 1605             


Asp Asn  Phe Leu Glu Arg Thr  Asn Ser Leu Pro Pro  Val Met Ala 
    1610                 1615                 1620             


Asn Gln  Arg Pro Leu Gln Phe  Ala Glu Ile Glu Met  Glu Glu Met 
    1625                 1630                 1635             


Glu Ser  Pro Val Phe Leu Glu  Asp Phe Pro Gln Asp  Pro Arg Thr 
    1640                 1645                 1650             


Asn Pro  Leu Ala Arg Ala Asn  Thr Asn Asn Ala Asn  Ala Asn Val 
    1655                 1660                 1665             


Ala Tyr  Gly Asn Ser Asn His  Ser Asn Ser His Val  Phe Ser Ser 
    1670                 1675                 1680             


Val His  Tyr Glu Arg Glu Phe  Pro Glu Glu Thr Glu  Thr Pro Ala 
    1685                 1690                 1695             


Thr Arg  Gly Arg Ala Leu Gly  Gln Pro Cys Arg Val  Leu Gly Pro 
    1700                 1705                 1710             


His Ser  Lys Pro Cys Val Glu  Met Leu Lys Gly Leu  Leu Thr Gln 
    1715                 1720                 1725             


Arg Ala  Met Pro Arg Gly Gln  Ala Pro Pro Ala Pro  Cys Gln Cys 
    1730                 1735                 1740             


Pro Arg  Val Glu Ser Ser Met  Pro Glu Asp Arg Lys  Ser Ser Thr 
    1745                 1750                 1755             


Pro Gly  Ser Leu His Glu Glu  Thr Pro His Ser Arg  Ser Thr Arg 
    1760                 1765                 1770             


Glu Asn  Thr Ser Arg Cys Ser  Ala Pro Ala Thr Ala  Leu Leu Ile 
    1775                 1780                 1785             


Gln Lys  Ala Leu Val Arg Gly  Gly Leu Gly Thr Leu  Ala Ala Asp 
    1790                 1795                 1800             


Ala Asn  Phe Ile Met Ala Thr  Gly Gln Ala Leu Ala  Asp Ala Cys 
    1805                 1810                 1815             


Gln Met  Glu Pro Glu Glu Val  Glu Ile Met Ala Thr  Glu Leu Leu 
    1820                 1825                 1830             


Lys Gly  Arg Glu Ala Pro Glu  Gly Met Ala Ser Ser  Leu Gly Cys 
    1835                 1840                 1845             


Leu Asn  Leu Gly Ser Ser Leu  Gly Ser Leu Asp Gln  His Gln Gly 
    1850                 1855                 1860             


Ser Gln  Glu Thr Leu Ile Pro  Pro Arg Leu 
    1865                 1870             


<210>  9
<211>  1984
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ser Glu Ser Glu Val Gly Lys Asp Thr Thr Pro Glu Pro Ser Pro 
1               5                   10                  15      


Ala Asn Gly Thr Gly Pro Gly Pro Glu Trp Gly Leu Cys Pro Gly Pro 
            20                  25                  30          


Pro Thr Val Gly Thr Asp Thr Ser Gly Ala Ser Gly Leu Gly Thr Pro 
        35                  40                  45              


Arg Arg Arg Thr Gln His Asn Lys His Lys Thr Val Ala Val Ala Ser 
    50                  55                  60                  


Ala Gln Arg Ser Pro Arg Ala Leu Phe Cys Leu Thr Leu Thr Asn Pro 
65                  70                  75                  80  


Ile Arg Arg Ser Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Asp Ile 
                85                  90                  95      


Leu Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Gly Val Tyr 
            100                 105                 110         


Ile Pro Phe Pro Glu Asp Asp Ser Asn Thr Ala Asn His Asn Leu Glu 
        115                 120                 125             


Gln Val Glu Tyr Val Phe Leu Val Ile Phe Thr Val Glu Thr Val Leu 
    130                 135                 140                 


Lys Ile Val Ala Tyr Gly Leu Val Leu His Pro Ser Ala Tyr Ile Arg 
145                 150                 155                 160 


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
                165                 170                 175     


Ser Val Leu Leu Glu Gln Gly Pro Gly Arg Pro Gly Asp Ala Pro His 
            180                 185                 190         


Thr Gly Gly Lys Pro Gly Gly Phe Asp Val Lys Ala Leu Arg Ala Phe 
        195                 200                 205             


Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu His 
    210                 215                 220                 


Ile Val Leu Asn Ser Ile Met Lys Ala Leu Val Pro Leu Leu His Ile 
225                 230                 235                 240 


Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu 
                245                 250                 255     


Glu Leu Phe Leu Gly Arg Met His Lys Thr Cys Tyr Phe Leu Gly Ser 
            260                 265                 270         


Asp Met Glu Ala Glu Glu Asp Pro Ser Pro Cys Ala Ser Ser Gly Ser 
        275                 280                 285             


Gly Arg Ser Cys Thr Leu Asn His Thr Glu Cys Arg Gly Arg Trp Pro 
    290                 295                 300                 


Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Phe Phe Ala Met 
305                 310                 315                 320 


Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val Leu 
                325                 330                 335     


Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr Phe 
            340                 345                 350         


Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val Leu 
        355                 360                 365             


Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys Ala 
    370                 375                 380                 


Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Met Glu Glu Asp 
385                 390                 395                 400 


Leu Arg Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Glu Leu Asp Leu 
                405                 410                 415     


His Asp Pro Ser Val Asp Gly Asn Leu Ala Ser Leu Ala Glu Glu Gly 
            420                 425                 430         


Arg Ala Gly His Arg Pro Gln Leu Ser Glu Leu Thr Asn Arg Arg Arg 
        435                 440                 445             


Gly Arg Leu Arg Trp Phe Ser His Ser Thr Arg Ser Thr His Ser Thr 
    450                 455                 460                 


Ser Ser His Ala Ser Leu Pro Ala Ser Asp Thr Gly Ser Met Thr Asp 
465                 470                 475                 480 


Thr Pro Gly Asp Glu Asp Glu Glu Glu Gly Thr Met Ala Ser Cys Thr 
                485                 490                 495     


Arg Cys Leu Asn Lys Ile Met Lys Thr Arg Ile Cys Arg His Phe Arg 
            500                 505                 510         


Arg Ala Asn Arg Gly Leu Arg Ala Arg Cys Arg Arg Ala Val Lys Ser 
        515                 520                 525             


Asn Ala Cys Tyr Trp Ala Val Leu Leu Leu Val Phe Leu Asn Thr Leu 
    530                 535                 540                 


Thr Ile Ala Ser Glu His His Gly Gln Pro Leu Trp Leu Thr Gln Thr 
545                 550                 555                 560 


Gln Glu Tyr Ala Asn Lys Val Leu Leu Cys Leu Phe Thr Val Glu Met 
                565                 570                 575     


Leu Leu Lys Leu Tyr Gly Leu Gly Pro Ser Val Tyr Val Ala Ser Phe 
            580                 585                 590         


Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Leu Glu Thr 
        595                 600                 605             


Thr Leu Val Glu Val Gly Ala Met Gln Pro Leu Gly Ile Ser Val Leu 
    610                 615                 620                 


Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Ala 
625                 630                 635                 640 


Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile 
                645                 650                 655     


Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu 
            660                 665                 670         


Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Gln Thr His 
        675                 680                 685             


Thr Lys Arg Ser Thr Phe Asp Thr Phe Pro Gln Ala Leu Leu Thr Val 
    690                 695                 700                 


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Val Val Met Tyr Asp Gly 
705                 710                 715                 720 


Ile Met Ala Tyr Gly Gly Pro Phe Phe Pro Gly Met Leu Val Cys Val 
                725                 730                 735     


Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val 
            740                 745                 750         


Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Ser Gly Asp Ala Gly Thr 
        755                 760                 765             


Ala Lys Asp Lys Gly Arg Glu Lys Ser Ser Glu Gly Asn Pro Pro Lys 
    770                 775                 780                 


Glu Asn Lys Val Leu Val Pro Gly Gly Glu Asn Glu Asp Ala Lys Gly 
785                 790                 795                 800 


Ala Arg Ser Glu Gly Ala Ala Pro Gly Met Glu Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asn Gly Ala Gly His 
            820                 825                 830         


Val Glu Leu Leu Gln Glu Val Val Pro Lys Glu Lys Val Val Pro Ile 
        835                 840                 845             


Pro Glu Gly Ser Ala Phe Phe Cys Leu Ser Gln Thr Asn Pro Leu Arg 
    850                 855                 860                 


Lys Ala Cys His Thr Leu Ile His His His Ile Phe Thr Ser Leu Ile 
865                 870                 875                 880 


Leu Val Phe Ile Ile Leu Ser Ser Val Ser Leu Ala Ala Glu Asp Pro 
                885                 890                 895     


Ile Arg Ala His Ser Phe Arg Asn His Ile Leu Gly Tyr Phe Asp Tyr 
            900                 905                 910         


Ala Phe Thr Ser Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Val 
        915                 920                 925             


Phe Gly Ala Phe Leu His Arg Gly Ser Phe Cys Arg Ser Trp Phe Asn 
    930                 935                 940                 


Leu Leu Asp Leu Leu Val Val Ser Val Ser Leu Ile Ser Phe Gly Ile 
945                 950                 955                 960 


His Ser Ser Ala Ile Ser Val Val Lys Ile Leu Arg Val Leu Arg Val 
                965                 970                 975     


Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys Gly Leu Lys His Val 
            980                 985                 990         


Val Gln Cys Val Phe Val Ala Ile  Arg Thr Ile Gly Asn  Ile Met Ile 
        995                 1000                 1005             


Val Thr  Thr Leu Leu Gln Phe  Met Phe Ala Cys Ile  Gly Val Gln 
    1010                 1015                 1020             


Leu Phe  Lys Gly Lys Phe Tyr  Ser Cys Thr Asp Glu  Ala Lys His 
    1025                 1030                 1035             


Thr Leu  Lys Glu Cys Lys Gly  Ser Phe Leu Ile Tyr  Pro Asp Gly 
    1040                 1045                 1050             


Asp Val  Ser Arg Pro Leu Val  Arg Glu Arg Leu Trp  Val Asn Ser 
    1055                 1060                 1065             


Asp Phe  Asn Phe Asp Asn Val  Leu Ser Ala Met Met  Ala Leu Phe 
    1070                 1075                 1080             


Thr Val  Ser Thr Phe Glu Gly  Trp Pro Ala Leu Leu  Tyr Lys Ala 
    1085                 1090                 1095             


Ile Asp  Ala Asn Ala Glu Asp  Glu Gly Pro Ile Tyr  Asn Tyr His 
    1100                 1105                 1110             


Val Glu  Ile Ser Val Phe Phe  Ile Val Tyr Ile Ile  Ile Ile Ala 
    1115                 1120                 1125             


Phe Phe  Met Met Asn Ile Phe  Val Gly Phe Val Ile  Ile Thr Phe 
    1130                 1135                 1140             


Arg Ala  Gln Gly Glu Gln Glu  Tyr Gln Asn Cys Glu  Leu Asp Lys 
    1145                 1150                 1155             


Asn Gln  Arg Gln Cys Val Glu  Tyr Ala Leu Lys Ala  Gln Pro Leu 
    1160                 1165                 1170             


Arg Arg  Tyr Ile Pro Lys Asn  Pro His Gln Tyr Arg  Val Trp Ala 
    1175                 1180                 1185             


Thr Val  Asn Ser Ala Ala Phe  Glu Tyr Leu Met Phe  Leu Leu Ile 
    1190                 1195                 1200             


Leu Leu  Asn Thr Val Ala Leu  Ala Met Gln His Tyr  Glu Gln Thr 
    1205                 1210                 1215             


Ala Pro  Phe Asn Tyr Ala Met  Asp Ile Leu Asn Met  Val Phe Thr 
    1220                 1225                 1230             


Gly Leu  Phe Thr Ile Glu Met  Val Leu Lys Ile Ile  Ala Phe Lys 
    1235                 1240                 1245             


Pro Lys  His Tyr Phe Ala Asp  Ala Trp Asn Thr Phe  Asp Ala Leu 
    1250                 1255                 1260             


Ile Val  Val Gly Ser Val Val  Asp Ile Ala Val Thr  Glu Val Asn 
    1265                 1270                 1275             


Asn Gly  Gly His Leu Gly Glu  Ser Ser Glu Asp Ser  Ser Arg Ile 
    1280                 1285                 1290             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1295                 1300                 1305             


Leu Leu  Ser Lys Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1310                 1315                 1320             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Ala 
    1325                 1330                 1335             


Met Ile  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Met Phe Gly 
    1340                 1345                 1350             


Lys Val  Ala Leu Gln Asp Gly  Thr Gln Ile Asn Arg  Asn Asn Asn 
    1355                 1360                 1365             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1370                 1375                 1380             


Thr Gly  Glu Ala Trp Gln Glu  Ile Met Leu Ala Ser  Leu Pro Gly 
    1385                 1390                 1395             


Asn Arg  Cys Asp Pro Glu Ser  Asp Phe Gly Pro Gly  Glu Glu Phe 
    1400                 1405                 1410             


Thr Cys  Gly Ser Ser Phe Ala  Ile Val Tyr Phe Ile  Ser Phe Phe 
    1415                 1420                 1425             


Met Leu  Cys Ala Phe Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile 
    1430                 1435                 1440             


Met Asp  Asn Phe Asp Tyr Leu  Thr Arg Asp Trp Ser  Ile Leu Gly 
    1445                 1450                 1455             


Pro His  His Leu Asp Glu Phe  Lys Arg Ile Trp Ser  Glu Tyr Asp 
    1460                 1465                 1470             


Pro Gly  Ala Lys Gly Arg Ile  Lys His Leu Asp Val  Val Ala Leu 
    1475                 1480                 1485             


Leu Arg  Arg Ile Gln Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro 
    1490                 1495                 1500             


His Arg  Val Ala Cys Lys Arg  Leu Val Ala Met Asn  Val Pro Leu 
    1505                 1510                 1515             


Asn Ser  Asp Gly Thr Val Thr  Phe Asn Ala Thr Leu  Phe Ala Leu 
    1520                 1525                 1530             


Val Arg  Thr Ser Leu Lys Ile  Lys Thr Glu Gly Asn  Leu Asp Gln 
    1535                 1540                 1545             


Ala Asn  Gln Glu Leu Arg Met  Val Ile Lys Lys Ile  Trp Lys Arg 
    1550                 1555                 1560             


Ile Lys  Gln Lys Leu Leu Asp  Glu Val Ile Pro Pro  Pro Asp Glu 
    1565                 1570                 1575             


Glu Glu  Val Thr Val Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln 
    1580                 1585                 1590             


Asp Tyr  Phe Arg Lys Phe Arg  Arg Arg Lys Glu Lys  Gly Leu Leu 
    1595                 1600                 1605             


Gly Arg  Glu Ala Pro Thr Ser  Thr Ser Ser Ala Leu  Gln Ala Gly 
    1610                 1615                 1620             


Leu Arg  Ser Leu Gln Asp Leu  Gly Pro Glu Ile Arg  Gln Ala Leu 
    1625                 1630                 1635             


Thr Tyr  Asp Thr Glu Glu Glu  Glu Glu Glu Glu Glu  Ala Val Gly 
    1640                 1645                 1650             


Gln Glu  Ala Glu Glu Glu Glu  Ala Glu Asn Asn Pro  Glu Pro Tyr 
    1655                 1660                 1665             


Lys Asp  Ser Ile Asp Ser Gln  Pro Gln Ser Arg Trp  Asn Ser Arg 
    1670                 1675                 1680             


Ile Ser  Val Ser Leu Pro Val  Lys Glu Lys Leu Pro  Asp Ser Leu 
    1685                 1690                 1695             


Ser Thr  Gly Pro Ser Asp Asp  Asp Gly Leu Ala Pro  Asn Ser Arg 
    1700                 1705                 1710             


Gln Pro  Ser Val Ile Gln Ala  Gly Ser Gln Pro His  Arg Arg Ser 
    1715                 1720                 1725             


Ser Gly  Val Phe Met Phe Thr  Ile Pro Glu Glu Gly  Ser Ile Gln 
    1730                 1735                 1740             


Leu Lys  Gly Thr Gln Gly Gln  Asp Asn Gln Asn Glu  Glu Gln Glu 
    1745                 1750                 1755             


Val Pro  Asp Trp Thr Pro Asp  Leu Asp Glu Gln Ala  Gly Thr Pro 
    1760                 1765                 1770             


Ser Asn  Pro Val Leu Leu Pro  Pro His Trp Ser Gln  Gln His Val 
    1775                 1780                 1785             


Asn Gly  His His Val Pro Arg  Arg Arg Leu Leu Pro  Pro Thr Pro 
    1790                 1795                 1800             


Ala Gly  Arg Lys Pro Ser Phe  Thr Ile Gln Cys Leu  Gln Arg Gln 
    1805                 1810                 1815             


Gly Ser  Cys Glu Asp Leu Pro  Ile Pro Gly Thr Tyr  His Arg Gly 
    1820                 1825                 1830             


Arg Thr  Ser Gly Pro Ser Arg  Ala Gln Gly Ser Trp  Ala Ala Pro 
    1835                 1840                 1845             


Pro Gln  Lys Gly Arg Leu Leu  Tyr Ala Pro Leu Leu  Leu Val Glu 
    1850                 1855                 1860             


Glu Ser  Thr Val Gly Glu Gly  Tyr Leu Gly Lys Leu  Gly Gly Pro 
    1865                 1870                 1875             


Leu Arg  Thr Phe Thr Cys Leu  Gln Val Pro Gly Ala  His Pro Asn 
    1880                 1885                 1890             


Pro Ser  His Arg Lys Arg Gly  Ser Ala Asp Ser Leu  Val Glu Ala 
    1895                 1900                 1905             


Val Leu  Ile Ser Glu Gly Leu  Gly Leu Phe Ala Gln  Asp Pro Arg 
    1910                 1915                 1920             


Phe Val  Ala Leu Ala Lys Gln  Glu Ile Ala Asp Ala  Cys His Leu 
    1925                 1930                 1935             


Thr Leu  Asp Glu Met Asp Ser  Ala Ala Ser Asp Leu  Leu Ala Gln 
    1940                 1945                 1950             


Arg Thr  Thr Ser Leu Tyr Ser  Asp Glu Glu Ser Ile  Leu Ser Arg 
    1955                 1960                 1965             


Phe Asp  Glu Glu Asp Leu Gly  Asp Glu Met Ala Cys  Val His Ala 
    1970                 1975                 1980             


Leu 
    


<210>  10
<211>  2166
<212>  PRT
<213>  Mus musculus

<400>  10

Met Asn Leu Pro Thr Phe Ser Ser Asp Leu Ile Leu Ile Lys Ser Val 
1               5                   10                  15      


Leu Ser Gln Glu Thr Asp Ala Arg Tyr Lys Gly Arg Val Val Ser Ala 
            20                  25                  30          


Val Glu Ser Thr Glu Asp Phe Ser Gln Ala Phe Ala Glu Ala Asn Tyr 
        35                  40                  45              


Ala Arg Gly Thr Arg Leu Pro Ile Ser Gly Glu Gly Pro Thr Ser Gln 
    50                  55                  60                  


Pro Asn Ser Ser Lys Gln Thr Val Leu Ser Trp Gln Ala Ala Ile Asp 
65                  70                  75                  80  


Ala Ala Arg Gln Ala Lys Ala Ala Gln Thr Met Ser Thr Ser Ala Pro 
                85                  90                  95      


Pro Pro Val Gly Ser Leu Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys 
            100                 105                 110         


Ser Lys Lys Gln Gly Asn Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu 
        115                 120                 125             


Phe Cys Leu Ser Leu Asn Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile 
    130                 135                 140                 


Val Glu Trp Lys Pro Phe Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala 
145                 150                 155                 160 


Asn Cys Val Ala Leu Ala Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser 
                165                 170                 175     


Asn Ser Thr Asn His Asn Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile 
            180                 185                 190         


Ile Phe Thr Val Glu Thr Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu 
        195                 200                 205             


Leu His Pro Asn Ala Tyr Val Arg Asn Gly Trp Asn Leu Leu Asp Phe 
    210                 215                 220                 


Val Ile Val Ile Val Gly Leu Phe Ser Val Ile Leu Glu Gln Leu Thr 
225                 230                 235                 240 


Lys Glu Thr Glu Gly Gly Asn His Ser Ser Gly Lys Ser Gly Gly Phe 
                245                 250                 255     


Asp Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro Leu Arg Leu 
            260                 265                 270         


Val Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser Ile Ile Lys 
        275                 280                 285             


Ala Met Val Pro Leu Leu His Ile Ala Leu Leu Val Leu Phe Val Ile 
    290                 295                 300                 


Ile Ile Tyr Ala Ile Ile Gly Leu Glu Leu Phe Ile Gly Lys Met His 
305                 310                 315                 320 


Lys Thr Cys Phe Phe Ala Asp Ser Asp Ile Val Ala Glu Glu Asp Pro 
                325                 330                 335     


Ala Pro Cys Ala Phe Ser Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly 
            340                 345                 350         


Thr Glu Cys Arg Ser Gly Trp Val Gly Pro Asn Gly Gly Ile Thr Asn 
        355                 360                 365             


Phe Asp Asn Phe Ala Phe Ala Met Leu Thr Val Phe Gln Cys Ile Thr 
    370                 375                 380                 


Met Glu Gly Trp Thr Asp Val Leu Tyr Trp Val Asn Asp Ala Ile Gly 
385                 390                 395                 400 


Trp Glu Trp Pro Trp Val Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser 
                405                 410                 415     


Phe Phe Val Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ser 
            420                 425                 430         


Lys Glu Arg Glu Lys Ala Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg 
        435                 440                 445             


Glu Lys Gln Gln Leu Glu Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile 
    450                 455                 460                 


Thr Gln Ala Glu Asp Ile Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu 
465                 470                 475                 480 


Glu Gly Lys Arg Asn Thr Ser Met Pro Thr Ser Glu Thr Glu Ser Val 
                485                 490                 495     


Asn Thr Glu Asn Val Ser Gly Glu Gly Glu Thr Gln Gly Cys Cys Gly 
            500                 505                 510         


Thr Leu Cys Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg 
        515                 520                 525             


Arg Trp Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys Ser 
    530                 535                 540                 


Val Thr Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn Thr Leu 
545                 550                 555                 560 


Thr Ile Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile 
                565                 570                 575     


Gln Asp Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Thr Cys Glu Met 
            580                 585                 590         


Leu Val Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu 
        595                 600                 605             


Phe Asn Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Thr Glu Thr 
    610                 615                 620                 


Ile Leu Val Glu Leu Glu Leu Met Ser Pro Leu Gly Val Ser Val Phe 
625                 630                 635                 640 


Arg Cys Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Thr 
                645                 650                 655     


Ser Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile 
            660                 665                 670         


Ala Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu 
        675                 680                 685             


Leu Gly Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln 
    690                 695                 700                 


Thr Lys Arg Ser Thr Phe Asp Asn Phe Pro Gln Ala Leu Leu Thr Val 
705                 710                 715                 720 


Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr Asp Gly 
                725                 730                 735     


Ile Met Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val Cys Ile 
            740                 745                 750         


Tyr Phe Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val 
        755                 760                 765             


Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn 
    770                 775                 780                 


Thr Ala Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala 
785                 790                 795                 800 


Arg Lys Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu Val Asn 
                805                 810                 815     


Gln Ile Ala Asn Ser Asp Asn Lys Val Thr Ile Asp Asp Tyr Gln Glu 
            820                 825                 830         


Asp Ala Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro Val Gly 
        835                 840                 845             


Glu Glu Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro Ala Gly 
    850                 855                 860                 


Pro Arg Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys Ile Ala 
865                 870                 875                 880 


Pro Ile Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro 
                885                 890                 895     


Ile Arg Val Gly Cys His Lys Leu Ile Asn His His Ile Phe Thr Asn 
            900                 905                 910         


Leu Ile Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala Ala Glu 
        915                 920                 925             


Asp Pro Ile Arg Ser His Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe 
    930                 935                 940                 


Asp Tyr Ala Phe Thr Ala Ile Phe Thr Val Glu Ile Leu Leu Lys Met 
945                 950                 955                 960 


Thr Thr Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg Asn Tyr 
                965                 970                 975     


Phe Asn Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val Ser Phe 
            980                 985                 990         


Gly Ile Gln Ser Ser Ala Ile Ser  Val Val Lys Ile Leu  Arg Val Leu 
        995                 1000                 1005             


Arg Val  Leu Arg Pro Leu Arg  Ala Ile Asn Arg Ala  Lys Gly Leu 
    1010                 1015                 1020             


Lys His  Val Val Gln Cys Val  Phe Val Ala Ile Arg  Thr Ile Gly 
    1025                 1030                 1035             


Asn Ile  Met Ile Val Thr Thr  Leu Leu Gln Phe Met  Phe Ala Cys 
    1040                 1045                 1050             


Ile Gly  Val Gln Leu Phe Lys  Gly Lys Phe Tyr Arg  Cys Thr Asp 
    1055                 1060                 1065             


Glu Ala  Lys Ser Asn Pro Glu  Glu Cys Arg Gly Leu  Phe Ile Leu 
    1070                 1075                 1080             


Tyr Lys  Asp Gly Asp Val Asp  Ser Pro Val Val Arg  Glu Arg Ile 
    1085                 1090                 1095             


Trp Gln  Asn Ser Asp Phe Asn  Phe Asp Asn Val Leu  Ser Ala Met 
    1100                 1105                 1110             


Met Ala  Leu Phe Thr Val Ser  Thr Phe Glu Gly Trp  Pro Ala Leu 
    1115                 1120                 1125             


Leu Tyr  Lys Ala Ile Asp Ser  Asn Gly Glu Asn Val  Gly Pro Val 
    1130                 1135                 1140             


Tyr Asn  Tyr Arg Val Glu Ile  Ser Ile Phe Phe Ile  Ile Tyr Ile 
    1145                 1150                 1155             


Ile Ile  Val Ala Phe Phe Met  Met Asn Ile Phe Val  Gly Phe Val 
    1160                 1165                 1170             


Ile Val  Thr Phe Gln Glu Gln  Gly Glu Lys Glu Tyr  Lys Asn Cys 
    1175                 1180                 1185             


Glu Leu  Asp Lys Asn Gln Arg  Gln Cys Val Glu Tyr  Ala Leu Lys 
    1190                 1195                 1200             


Ala Arg  Pro Leu Arg Arg Tyr  Ile Pro Lys Asn Pro  Tyr Gln Tyr 
    1205                 1210                 1215             


Lys Phe  Trp Tyr Val Val Asn  Ser Ser Pro Phe Glu  Tyr Met Met 
    1220                 1225                 1230             


Phe Val  Leu Ile Met Leu Asn  Thr Leu Cys Leu Ala  Met Gln His 
    1235                 1240                 1245             


Tyr Glu  Gln Ser Lys Met Phe  Asn Asp Ala Met Asp  Ile Leu Asn 
    1250                 1255                 1260             


Met Val  Phe Thr Gly Val Phe  Thr Val Glu Met Val  Leu Lys Val 
    1265                 1270                 1275             


Ile Ala  Phe Lys Pro Lys Gly  Tyr Phe Ser Asp Ala  Trp Asn Thr 
    1280                 1285                 1290             


Phe Asp  Ser Leu Ile Val Ile  Gly Ser Ile Ile Asp  Val Ala Leu 
    1295                 1300                 1305             


Ser Glu  Ala Asp Asn Ser Glu  Glu Ser Asn Arg Ile  Ser Ile Thr 
    1310                 1315                 1320             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Val Lys  Leu Leu Ser 
    1325                 1330                 1335             


Arg Gly  Glu Gly Ile Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1340                 1345                 1350             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Ala  Met Leu Phe 
    1355                 1360                 1365             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Val Ala 
    1370                 1375                 1380             


Met Arg  Asp Asn Asn Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1385                 1390                 1395             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1400                 1405                 1410             


Ala Trp  Gln Glu Ile Met Leu  Ala Cys Leu Pro Gly  Lys Leu Cys 
    1415                 1420                 1425             


Asp Pro  Asp Ser Asp Tyr Asn  Pro Gly Glu Glu Tyr  Thr Cys Gly 
    1430                 1435                 1440             


Ser Asn  Phe Ala Ile Val Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys 
    1445                 1450                 1455             


Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1460                 1465                 1470             


Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1475                 1480                 1485             


Leu Asp  Glu Phe Lys Arg Ile  Trp Ser Glu Tyr Asp  Pro Glu Ala 
    1490                 1495                 1500             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Thr Leu  Leu Arg Arg 
    1505                 1510                 1515             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu Cys Pro  His Arg Val 
    1520                 1525                 1530             


Ala Cys  Lys Arg Leu Val Ala  Met Asn Met Pro Leu  Asn Ser Asp 
    1535                 1540                 1545             


Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr 
    1550                 1555                 1560             


Ala Leu  Lys Ile Lys Thr Glu  Gly Asn Leu Glu Gln  Ala Asn Glu 
    1565                 1570                 1575             


Glu Leu  Arg Ala Val Ile Lys  Lys Ile Trp Lys Lys  Thr Ser Met 
    1580                 1585                 1590             


Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala Gly Asp  Asp Glu Val 
    1595                 1600                 1605             


Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu Ile Gln  Asp Tyr Phe 
    1610                 1615                 1620             


Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly Leu Val  Gly Lys Tyr 
    1625                 1630                 1635             


Pro Ala  Lys Asn Thr Thr Ile  Ala Leu Gln Ala Gly  Leu Arg Thr 
    1640                 1645                 1650             


Leu His  Asp Ile Gly Pro Glu  Ile Arg Arg Ala Ile  Ser Cys Asp 
    1655                 1660                 1665             


Leu Gln  Asp Asp Glu Pro Glu  Asp Ser Lys Pro Glu  Glu Glu Asp 
    1670                 1675                 1680             


Val Phe  Lys Arg Asn Gly Ala  Leu Leu Gly Asn His  Val Asn His 
    1685                 1690                 1695             


Val Asn  Ser Asp Arg Arg Asp  Ser Leu Gln Gln Thr  Asn Thr Thr 
    1700                 1705                 1710             


His Arg  Pro Leu His Val Gln  Arg Pro Ser Met Pro  Pro Ala Ser 
    1715                 1720                 1725             


Asp Thr  Glu Lys Pro Leu Phe  Pro Pro Ala Gly Asn  Ser Gly Cys 
    1730                 1735                 1740             


His Asn  His His Asn His Asn  Ser Ile Gly Lys Gln  Ala Pro Thr 
    1745                 1750                 1755             


Ser Thr  Asn Ala Asn Leu Asn  Asn Ala Asn Met Ser  Lys Ala Ala 
    1760                 1765                 1770             


His Gly  Lys Pro Pro Ser Ile  Gly Asn Leu Glu His  Val Ser Glu 
    1775                 1780                 1785             


Asn Gly  His Tyr Ser Cys Lys  His Asp Arg Glu Leu  Gln Arg Arg 
    1790                 1795                 1800             


Ser Ser  Ile Lys Arg Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser 
    1805                 1810                 1815             


Glu Ser  Gly Asp Glu Gln Phe  Pro Thr Ile Cys Arg  Glu Asp Pro 
    1820                 1825                 1830             


Glu Ile  His Gly Tyr Phe Arg  Asp Pro Arg Cys Leu  Gly Glu Gln 
    1835                 1840                 1845             


Glu Tyr  Phe Ser Ser Glu Glu  Cys Cys Glu Asp Asp  Ser Ser Pro 
    1850                 1855                 1860             


Thr Trp  Ser Arg Gln Asn Tyr  Asn Tyr Tyr Asn Arg  Tyr Pro Gly 
    1865                 1870                 1875             


Ser Ser  Met Asp Phe Glu Arg  Pro Arg Gly Tyr His  His Pro Gln 
    1880                 1885                 1890             


Gly Phe  Leu Glu Asp Asp Asp  Ser Pro Thr Gly Tyr  Asp Ser Arg 
    1895                 1900                 1905             


Arg Ser  Pro Arg Arg Arg Leu  Leu Pro Pro Thr Pro  Pro Ser His 
    1910                 1915                 1920             


Arg Arg  Ser Ser Phe Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser 
    1925                 1930                 1935             


Gln Asp  Asp Val Leu Pro Ser  Pro Ala Leu Pro His  Arg Ala Ala 
    1940                 1945                 1950             


Leu Pro  Leu His Leu Met Gln  Gln Gln Ile Met Ala  Val Ala Gly 
    1955                 1960                 1965             


Leu Asp  Ser Ser Lys Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr 
    1970                 1975                 1980             


Arg Ser  Trp Ala Thr Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp 
    1985                 1990                 1995             


Ser Pro  Cys Tyr Thr Pro Leu  Ile Gln Val Asp Arg  Ser Glu Ser 
    2000                 2005                 2010             


Met Asp  Gln Val Asn Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser 
    2015                 2020                 2025             


Trp Tyr  Thr Asp Glu Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro 
    2030                 2035                 2040             


Ala Ser  Leu Thr Val Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp 
    2045                 2050                 2055             


Lys Gln  Arg Ser Ala Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2060                 2065                 2070             


Glu Gly  Leu Gly Arg Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala 
    2075                 2080                 2085             


Thr Lys  His Glu Ile Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu 
    2090                 2095                 2100             


Met Glu  Ser Ala Ala Ser Thr  Leu Leu Asn Gly Ser  Val Cys Pro 
    2105                 2110                 2115             


Arg Ala  Asn Gly Asp Met Gly  Pro Ile Ser His Arg  Gln Asp Tyr 
    2120                 2125                 2130             


Glu Leu  Gln Asp Phe Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp 
    2135                 2140                 2145             


Pro Gly  Arg Glu Glu Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile 
    2150                 2155                 2160             


Thr Thr  Leu 
    2165     


<210>  11
<211>  2139
<212>  PRT
<213>  Mus musculus

<400>  11

Met Val Asn Glu Asn Thr Arg Met Tyr Val Pro Glu Glu Asn His Gln 
1               5                   10                  15      


Gly Ser Asn Tyr Gly Ser Pro Arg Pro Ala His Ala Asn Met Asn Ala 
            20                  25                  30          


Asn Ala Ala Ala Gly Leu Ala Pro Glu His Ile Pro Thr Pro Gly Ala 
        35                  40                  45              


Ala Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys Leu 
    50                  55                  60                  


Met Gly Ser Ala Gly Asn Ala Thr Ile Ser Thr Val Ser Ser Thr Gln 
65                  70                  75                  80  


Arg Lys Arg Gln Gln Tyr Gly Lys Pro Lys Lys Gln Gly Gly Thr Thr 
                85                  90                  95      


Ala Thr Arg Pro Pro Arg Ala Leu Leu Cys Leu Thr Leu Lys Asn Pro 
            100                 105                 110         


Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe Glu Ile 
        115                 120                 125             


Ile Ile Leu Leu Thr Ile Phe Ala Asn Cys Val Ala Leu Ala Ile Tyr 
    130                 135                 140                 


Ile Pro Phe Pro Glu Asp Asp Ser Asn Ala Thr Asn Ser Asn Leu Glu 
145                 150                 155                 160 


Arg Val Glu Tyr Leu Phe Leu Ile Ile Phe Thr Val Glu Ala Phe Leu 
                165                 170                 175     


Lys Val Ile Ala Tyr Gly Leu Leu Phe His Pro Asn Ala Tyr Leu Arg 
            180                 185                 190         


Asn Gly Trp Asn Leu Leu Asp Phe Ile Ile Val Val Val Gly Leu Phe 
        195                 200                 205             


Ser Ala Ile Leu Glu Gln Ala Thr Lys Ala Asp Gly Ala Asn Ala Leu 
    210                 215                 220                 


Gly Gly Lys Gly Ala Gly Phe Asp Val Lys Ala Leu Arg Ala Phe Arg 
225                 230                 235                 240 


Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser Leu Gln Val 
                245                 250                 255     


Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu His Ile Ala 
            260                 265                 270         


Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile Gly Leu Glu 
        275                 280                 285             


Leu Phe Met Gly Lys Met His Lys Thr Cys Tyr Asn Gln Glu Gly Ile 
    290                 295                 300                 


Ile Asp Val Pro Ala Glu Glu Asp Pro Ser Pro Cys Ala Leu Glu Thr 
305                 310                 315                 320 


Gly His Gly Arg Gln Cys Gln Asn Gly Thr Val Cys Lys Pro Gly Trp 
                325                 330                 335     


Asp Gly Pro Lys His Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe Ala 
            340                 345                 350         


Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp Val 
        355                 360                 365             


Leu Tyr Trp Met Gln Asp Ala Met Gly Tyr Glu Leu Pro Trp Val Tyr 
    370                 375                 380                 


Phe Val Ser Leu Val Ile Phe Gly Ser Phe Phe Val Leu Asn Leu Val 
385                 390                 395                 400 


Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala Lys 
                405                 410                 415     


Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu Glu 
            420                 425                 430         


Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile Asp 
        435                 440                 445             


Pro Glu Asn Glu Asp Glu Gly Met Asp Glu Asp Lys Pro Arg Asn Met 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ala 
465                 470                 475                 480 


Gly Gly Asp Ile Glu Gly Glu Asn Cys Gly Ala Arg Leu Ala His Arg 
                485                 490                 495     


Ile Ser Lys Ser Lys Phe Ser Arg Tyr Trp Arg Arg Trp Asn Arg Phe 
            500                 505                 510         


Cys Arg Arg Lys Cys Arg Ala Ala Val Lys Ser Asn Val Phe Tyr Trp 
        515                 520                 525             


Leu Val Ile Phe Leu Val Phe Leu Asn Thr Leu Thr Ile Ala Ser Glu 
    530                 535                 540                 


His Tyr Asn Gln Pro His Trp Leu Thr Glu Val Gln Asp Thr Ala Asn 
545                 550                 555                 560 


Lys Ala Leu Leu Ala Leu Phe Thr Ala Glu Met Leu Leu Lys Met Tyr 
                565                 570                 575     


Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn Arg Phe Asp 
            580                 585                 590         


Cys Phe Ile Val Cys Gly Gly Ile Leu Glu Thr Ile Leu Val Glu Thr 
        595                 600                 605             


Lys Ile Met Ser Pro Leu Gly Ile Ser Val Leu Arg Cys Val Arg Leu 
    610                 615                 620                 


Leu Arg Ile Phe Lys Ile Thr Arg Tyr Trp Asn Ser Leu Ser Asn Leu 
625                 630                 635                 640 


Val Ala Ser Leu Leu Asn Ser Val Arg Ser Ile Ala Ser Leu Leu Leu 
                645                 650                 655     


Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly Met Gln Leu 
            660                 665                 670         


Phe Gly Gly Lys Phe Asn Phe Asp Glu Met Gln Thr Arg Arg Ser Thr 
        675                 680                 685             


Phe Asp Asn Phe Pro Gln Ser Leu Leu Thr Val Phe Gln Ile Leu Thr 
    690                 695                 700                 


Gly Glu Asp Trp Asn Ser Val Met Tyr Asp Gly Ile Met Ala Tyr Gly 
705                 710                 715                 720 


Gly Pro Ser Phe Pro Gly Met Leu Val Cys Ile Tyr Phe Ile Ile Leu 
                725                 730                 735     


Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu Ala Ile Ala 
            740                 745                 750         


Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Thr Ser Ala Gln Lys Glu 
        755                 760                 765             


Glu Glu Glu Glu Lys Glu Arg Lys Lys Leu Ala Arg Thr Ala Ser Pro 
    770                 775                 780                 


Glu Lys Lys Gln Glu Val Met Glu Lys Pro Ala Val Glu Glu Ser Lys 
785                 790                 795                 800 


Glu Glu Lys Ile Glu Leu Lys Ser Ile Thr Ala Asp Gly Glu Ser Pro 
                805                 810                 815     


Pro Thr Thr Lys Ile Asn Met Asp Asp Leu Gln Pro Ser Glu Asn Glu 
            820                 825                 830         


Asp Lys Ser Pro His Ser Asn Pro Asp Thr Ala Gly Glu Glu Asp Glu 
        835                 840                 845             


Glu Glu Pro Glu Met Pro Val Gly Pro Arg Pro Arg Pro Leu Ser Glu 
    850                 855                 860                 


Leu His Leu Lys Glu Lys Ala Val Pro Met Pro Glu Ala Ser Ala Phe 
865                 870                 875                 880 


Phe Ile Phe Ser Pro Asn Asn Arg Phe Arg Leu Gln Cys His Arg Ile 
                885                 890                 895     


Val Asn Asp Thr Ile Phe Thr Asn Leu Ile Leu Phe Phe Ile Leu Leu 
            900                 905                 910         


Ser Ser Ile Ser Leu Ala Ala Glu Asp Pro Val Gln His Thr Ser Phe 
        915                 920                 925             


Arg Asn His Ile Leu Gly Asn Ala Asp Tyr Val Phe Thr Ser Ile Phe 
    930                 935                 940                 


Thr Leu Glu Ile Ile Leu Lys Met Thr Ala Tyr Gly Ala Phe Leu His 
945                 950                 955                 960 


Lys Gly Ser Phe Cys Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val 
                965                 970                 975     


Val Ser Val Ser Leu Ile Ser Phe Gly Ile Gln Ser Ser Ala Ile Asn 
            980                 985                 990         


Val Val Lys Ile Leu Arg Val Leu  Arg Val Leu Arg Pro  Leu Arg Ala 
        995                 1000                 1005             


Ile Asn  Arg Ala Lys Gly Leu  Lys His Val Val Gln  Cys Val Phe 
    1010                 1015                 1020             


Val Ala  Ile Arg Thr Ile Gly  Asn Ile Val Ile Val  Thr Thr Leu 
    1025                 1030                 1035             


Leu Gln  Phe Met Phe Ala Cys  Ile Gly Val Gln Leu  Phe Lys Gly 
    1040                 1045                 1050             


Lys Leu  Tyr Thr Cys Ser Asp  Ser Ser Lys Gln Thr  Glu Ala Glu 
    1055                 1060                 1065             


Cys Lys  Gly Asn Tyr Ile Thr  Tyr Lys Asp Gly Glu  Val Asp His 
    1070                 1075                 1080             


Pro Ile  Ile Gln Pro Arg Ser  Trp Glu Asn Ser Lys  Phe Asp Phe 
    1085                 1090                 1095             


Asp Asn  Val Leu Ala Ala Met  Met Ala Leu Phe Thr  Val Ser Thr 
    1100                 1105                 1110             


Phe Glu  Gly Trp Pro Glu Leu  Leu Tyr Arg Ser Ile  Asp Ser His 
    1115                 1120                 1125             


Thr Glu  Asp Lys Gly Pro Ile  Tyr Asn Tyr Arg Val  Glu Ile Ser 
    1130                 1135                 1140             


Ile Phe  Phe Ile Ile Tyr Ile  Ile Ile Ile Ala Phe  Phe Met Met 
    1145                 1150                 1155             


Asn Ile  Phe Val Gly Phe Val  Ile Val Thr Phe Gln  Glu Gln Gly 
    1160                 1165                 1170             


Glu Gln  Glu Tyr Lys Asn Cys  Glu Leu Asp Lys Asn  Gln Arg Gln 
    1175                 1180                 1185             


Cys Val  Glu Tyr Ala Leu Lys  Ala Arg Pro Leu Arg  Arg Tyr Ile 
    1190                 1195                 1200             


Pro Lys  Asn Gln His Gln Tyr  Lys Val Trp Tyr Val  Val Asn Ser 
    1205                 1210                 1215             


Thr Tyr  Phe Glu Tyr Leu Met  Phe Val Leu Ile Leu  Leu Asn Thr 
    1220                 1225                 1230             


Ile Cys  Leu Ala Met Gln His  Tyr Gly Gln Ser Cys  Leu Phe Lys 
    1235                 1240                 1245             


Ile Ala  Met Asn Ile Leu Asn  Met Leu Phe Thr Gly  Leu Phe Thr 
    1250                 1255                 1260             


Val Glu  Met Ile Leu Lys Leu  Ile Ala Phe Lys Pro  Lys Gly Tyr 
    1265                 1270                 1275             


Phe Ser  Asp Pro Trp Asn Val  Phe Asp Phe Leu Ile  Val Ile Gly 
    1280                 1285                 1290             


Ser Ile  Ile Asp Val Ile Leu  Ser Glu Thr Asn Pro  Ala Glu His 
    1295                 1300                 1305             


Thr Gln  Cys Ser Pro Ser Met  Ser Ala Glu Glu Asn  Ser Arg Ile 
    1310                 1315                 1320             


Ser Ile  Thr Phe Phe Arg Leu  Phe Arg Val Met Arg  Leu Val Lys 
    1325                 1330                 1335             


Leu Leu  Ser Arg Gly Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe 
    1340                 1345                 1350             


Ile Lys  Ser Phe Gln Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Val 
    1355                 1360                 1365             


Met Leu  Phe Phe Ile Tyr Ala  Val Ile Gly Met Gln  Val Phe Gly 
    1370                 1375                 1380             


Lys Ile  Ala Leu Asn Asp Thr  Thr Glu Ile Asn Arg  Asn Asn Asn 
    1385                 1390                 1395             


Phe Gln  Thr Phe Pro Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala 
    1400                 1405                 1410             


Thr Gly  Glu Ala Trp Gln Asp  Ile Met Leu Ala Cys  Met Pro Gly 
    1415                 1420                 1425             


Lys Lys  Cys Ala Pro Glu Ser  Glu Pro Ser Asn Ser  Thr Glu Gly 
    1430                 1435                 1440             


Glu Thr  Pro Cys Gly Ser Ser  Phe Ala Val Phe Tyr  Phe Ile Ser 
    1445                 1450                 1455             


Phe Tyr  Met Leu Cys Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala 
    1460                 1465                 1470             


Val Ile  Met Asp Asn Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile 
    1475                 1480                 1485             


Leu Gly  Pro His His Leu Asp  Glu Phe Lys Arg Ile  Trp Ala Glu 
    1490                 1495                 1500             


Tyr Asp  Pro Glu Ala Lys Gly  Arg Ile Lys His Leu  Asp Val Val 
    1505                 1510                 1515             


Thr Leu  Leu Arg Arg Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Leu 
    1520                 1525                 1530             


Cys Pro  His Arg Val Ala Cys  Lys Arg Leu Val Ser  Met Asn Met 
    1535                 1540                 1545             


Pro Leu  Asn Ser Asp Gly Thr  Val Met Phe Asn Ala  Thr Leu Phe 
    1550                 1555                 1560             


Ala Leu  Val Arg Thr Ala Leu  Arg Ile Lys Thr Glu  Gly Asn Leu 
    1565                 1570                 1575             


Glu Gln  Ala Asn Glu Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp 
    1580                 1585                 1590             


Lys Arg  Thr Ser Met Lys Leu  Leu Asp Gln Val Val  Pro Pro Ala 
    1595                 1600                 1605             


Gly Asp  Asp Glu Val Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu 
    1610                 1615                 1620             


Ile Gln  Glu Tyr Phe Arg Lys  Phe Lys Lys Arg Lys  Glu Gln Gly 
    1625                 1630                 1635             


Leu Val  Gly Lys Pro Ser Gln  Arg Asn Ala Leu Ser  Leu Gln Ala 
    1640                 1645                 1650             


Gly Leu  Arg Thr Leu His Asp  Ile Gly Pro Glu Ile  Arg Arg Ala 
    1655                 1660                 1665             


Ile Ser  Gly Asp Leu Thr Ala  Glu Glu Glu Leu Asp  Lys Ala Met 
    1670                 1675                 1680             


Lys Glu  Ala Val Ser Ala Ala  Ser Glu Asp Asp Ile  Phe Arg Arg 
    1685                 1690                 1695             


Ala Gly  Gly Leu Phe Gly Asn  His Val Thr Tyr Tyr  Gln Ser Asp 
    1700                 1705                 1710             


Ser Arg  Gly Asn Phe Pro Gln  Thr Phe Ala Thr Gln  Arg Pro Leu 
    1715                 1720                 1725             


His Ile  Asn Lys Thr Gly Asn  Asn Gln Ala Asp Thr  Glu Ser Pro 
    1730                 1735                 1740             


Ser His  Glu Lys Leu Val Asp  Ser Thr Phe Thr Pro  Ser Ser Tyr 
    1745                 1750                 1755             


Ser Ser  Thr Gly Ser Asn Ala  Asn Ile Asn Asn Ala  Asn Asn Thr 
    1760                 1765                 1770             


Ala Leu  Gly Arg Phe Pro His  Pro Ala Gly Tyr Ser  Ser Thr Val 
    1775                 1780                 1785             


Ser Thr  Val Glu Gly His Gly  Pro Pro Leu Ser Pro  Ala Val Arg 
    1790                 1795                 1800             


Val Gln  Glu Ala Ala Trp Lys  Leu Ser Ser Lys Arg  Cys His Ser 
    1805                 1810                 1815             


Arg Glu  Ser Gln Gly Ala Thr  Val Asn Gln Glu Ile  Phe Pro Asp 
    1820                 1825                 1830             


Glu Thr  Arg Ser Val Arg Met  Ser Glu Glu Ala Glu  Tyr Cys Ser 
    1835                 1840                 1845             


Glu Pro  Ser Leu Leu Ser Thr  Asp Met Phe Ser Tyr  Gln Glu Asp 
    1850                 1855                 1860             


Glu His  Arg Gln Leu Thr Cys  Pro Glu Glu Asp Lys  Arg Glu Ile 
    1865                 1870                 1875             


Gln Pro  Ser Pro Lys Arg Ser  Phe Leu Arg Ser Ala  Ser Leu Gly 
    1880                 1885                 1890             


Arg Arg  Ala Ser Phe His Leu  Glu Cys Leu Lys Arg  Gln Lys Asp 
    1895                 1900                 1905             


Gln Gly  Gly Asp Ile Ser Gln  Lys Thr Ala Leu Pro  Leu His Leu 
    1910                 1915                 1920             


Val His  His Gln Ala Leu Ala  Val Ala Gly Leu Ser  Pro Leu Leu 
    1925                 1930                 1935             


Gln Arg  Ser His Ser Pro Thr  Thr Phe Pro Arg Pro  Cys Pro Thr 
    1940                 1945                 1950             


Pro Pro  Val Thr Pro Gly Ser  Arg Gly Arg Pro Leu  Arg Pro Ile 
    1955                 1960                 1965             


Pro Thr  Leu Arg Leu Glu Gly  Ala Glu Ser Ser Glu  Lys Leu Asn 
    1970                 1975                 1980             


Ser Ser  Phe Pro Ser Ile His  Cys Ser Ser Trp Ser  Glu Glu Thr 
    1985                 1990                 1995             


Thr Ala  Cys Ser Gly Ser Ser  Ser Met Ala Arg Arg  Ala Arg Pro 
    2000                 2005                 2010             


Val Ser  Leu Thr Val Pro Ser  Gln Ala Gly Ala Pro  Gly Arg Gln 
    2015                 2020                 2025             


Phe His  Gly Ser Ala Ser Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2030                 2035                 2040             


Glu Gly  Leu Gly Gln Phe Ala  Gln Asp Pro Lys Phe  Ile Glu Val 
    2045                 2050                 2055             


Thr Thr  Gln Glu Leu Ala Asp  Ala Cys Asp Met Thr  Ile Glu Glu 
    2060                 2065                 2070             


Met Glu  Asn Ala Ala Asp Asn  Ile Leu Ser Gly Gly  Ala Gln Gln 
    2075                 2080                 2085             


Ser Pro  Asn Gly Thr Leu Leu  Pro Phe Val Asn Cys  Arg Asp Pro 
    2090                 2095                 2100             


Gly Gln  Asp Arg Ala Val Ala  Pro Glu Asp Glu Ser  Cys Ala Tyr 
    2105                 2110                 2115             


Ala Leu  Gly Arg Gly Arg Ser  Glu Glu Ala Leu Ala  Asp Ser Arg 
    2120                 2125                 2130             


Ser Tyr  Val Ser Asn Leu 
    2135                 


<210>  12
<211>  1880
<212>  PRT
<213>  Mus musculus

<400>  12

Met Glu Pro Pro Ser Pro Gln Asp Glu Gly Leu Arg Lys Lys Gln Pro 
1               5                   10                  15      


Lys Lys Pro Val Pro Glu Ile Leu Pro Arg Pro Pro Arg Ala Leu Phe 
            20                  25                  30          


Cys Leu Thr Leu Gln Asn Pro Leu Arg Lys Ala Cys Ile Ser Ile Val 
        35                  40                  45              


Glu Trp Lys Pro Phe Glu Thr Ile Ile Leu Leu Thr Ile Phe Ala Asn 
    50                  55                  60                  


Cys Val Ala Leu Ala Val Tyr Leu Pro Met Pro Glu Asp Asp Asn Asn 
65                  70                  75                  80  


Thr Leu Asn Leu Gly Leu Glu Lys Leu Glu Tyr Phe Phe Leu Ile Val 
                85                  90                  95      


Phe Ser Ile Glu Ala Ala Met Lys Ile Ile Ala Tyr Gly Phe Leu Phe 
            100                 105                 110         


His Gln Asp Ala Tyr Leu Arg Ser Gly Trp Asn Val Leu Asp Phe Ile 
        115                 120                 125             


Ile Val Phe Leu Gly Val Phe Thr Val Ile Leu Glu Gln Val Asn Ile 
    130                 135                 140                 


Ile Gln Thr Asn Thr Ala Pro Met Ser Ser Lys Gly Ala Gly Leu Asp 
145                 150                 155                 160 


Val Lys Ala Leu Arg Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val 
                165                 170                 175     


Ser Gly Val Pro Ser Leu Gln Val Val Leu Asn Ser Ile Phe Lys Ala 
            180                 185                 190         


Met Leu Pro Leu Phe His Ile Ala Leu Leu Val Leu Phe Met Val Ile 
        195                 200                 205             


Ile Tyr Ala Ile Ile Gly Leu Glu Leu Phe Lys Gly Lys Met His Lys 
    210                 215                 220                 


Thr Cys Tyr Phe Ile Gly Thr Asp Ile Val Ala Thr Val Glu Asn Glu 
225                 230                 235                 240 


Lys Pro Ser Pro Cys Ala Arg Thr Gly Ser Gly Arg Pro Cys Thr Ile 
                245                 250                 255     


Asn Gly Ser Glu Cys Arg Gly Gly Trp Pro Gly Pro Asn His Gly Ile 
            260                 265                 270         


Thr His Phe Asp Asn Phe Gly Phe Ser Met Leu Thr Val Tyr Gln Cys 
        275                 280                 285             


Ile Ser Met Glu Gly Trp Thr Asp Val Leu Tyr Trp Val Asn Asp Ala 
    290                 295                 300                 


Ile Gly Asn Glu Trp Pro Trp Ile Tyr Phe Val Thr Leu Ile Leu Leu 
305                 310                 315                 320 


Gly Ser Phe Phe Ile Leu Asn Leu Val Leu Gly Val Leu Ser Gly Glu 
                325                 330                 335     


Phe Thr Lys Glu Arg Glu Lys Ala Lys Ser Arg Gly Thr Phe Gln Lys 
            340                 345                 350         


Leu Arg Glu Lys Gln Gln Leu Glu Glu Asp Leu Arg Gly Tyr Met Ser 
        355                 360                 365             


Trp Ile Thr Gln Gly Glu Val Met Asp Val Asp Asp Leu Arg Glu Gly 
    370                 375                 380                 


Lys Leu Ser Leu Asp Glu Gly Gly Ser Asp Thr Glu Ser Leu Tyr Glu 
385                 390                 395                 400 


Ile Glu Gly Leu Asn Lys Ile Ile Gln Phe Ile Arg His Trp Arg Gln 
                405                 410                 415     


Trp Asn Arg Val Phe Arg Trp Lys Cys His Asp Leu Val Lys Ser Lys 
            420                 425                 430         


Val Phe Tyr Trp Leu Val Ile Leu Ile Val Ala Leu Asn Thr Leu Ser 
        435                 440                 445             


Ile Ala Ser Glu His His Asn Gln Pro Leu Trp Leu Thr His Leu Gln 
    450                 455                 460                 


Asp Val Ala Asn Arg Val Leu Leu Thr Leu Phe Thr Ile Glu Met Leu 
465                 470                 475                 480 


Met Lys Met Tyr Gly Leu Gly Leu Arg Gln Tyr Phe Met Ser Ile Phe 
                485                 490                 495     


Asn Arg Phe Asp Cys Phe Val Val Cys Ser Gly Ile Leu Glu Ile Leu 
            500                 505                 510         


Leu Val Glu Ser Gly Ala Met Ser Pro Leu Gly Ile Ser Val Leu Arg 
        515                 520                 525             


Cys Ile Arg Leu Leu Arg Leu Phe Lys Ile Thr Lys Tyr Trp Thr Ser 
    530                 535                 540                 


Leu Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Ile Arg Ser Ile Ala 
545                 550                 555                 560 


Ser Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ala Leu Leu 
                565                 570                 575     


Gly Met Gln Leu Phe Gly Gly Arg Tyr Asp Phe Glu Asp Thr Glu Val 
            580                 585                 590         


Arg Arg Ser Asn Phe Asp Asn Phe Pro Gln Ala Leu Ile Ser Val Phe 
        595                 600                 605             


Gln Val Leu Thr Gly Glu Asp Trp Asn Ser Val Met Tyr Asn Gly Ile 
    610                 615                 620                 


Met Ala Tyr Gly Gly Pro Thr Tyr Pro Gly Val Leu Val Cys Ile Tyr 
625                 630                 635                 640 


Phe Ile Ile Leu Phe Val Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe 
                645                 650                 655     


Leu Ala Ile Ala Val Asp Asn Leu Ala Glu Ala Glu Ser Leu Thr Ser 
            660                 665                 670         


Ala Gln Lys Ala Lys Ala Glu Glu Arg Lys Arg Arg Lys Met Ser Lys 
        675                 680                 685             


Gly Leu Pro Asp Lys Ser Glu Glu Glu Arg Ala Thr Val Thr Lys Lys 
    690                 695                 700                 


Leu Glu Gln Lys Ser Lys Gly Glu Gly Ile Pro Thr Thr Ala Lys Leu 
705                 710                 715                 720 


Lys Ile Asp Glu Phe Glu Ser Asn Val Asn Glu Val Lys Asp Pro Tyr 
                725                 730                 735     


Pro Ser Ala Asp Phe Pro Gly Asp Asp Glu Glu Asp Glu Pro Glu Ile 
            740                 745                 750         


Pro Val Ser Pro Arg Pro Arg Pro Leu Ala Glu Leu Gln Leu Lys Glu 
        755                 760                 765             


Lys Ala Val Pro Ile Pro Glu Ala Ser Ser Phe Phe Ile Phe Ser Pro 
    770                 775                 780                 


Thr Asn Lys Ile Arg Val Leu Cys His Arg Ile Val Asn Ala Thr Trp 
785                 790                 795                 800 


Phe Thr Asn Phe Ile Leu Leu Phe Ile Leu Leu Ser Ser Ala Ala Leu 
                805                 810                 815     


Ala Ala Glu Asp Pro Ile Arg Ala Asp Ser Met Arg Asn Gln Ile Leu 
            820                 825                 830         


Glu Tyr Phe Asp Tyr Val Phe Thr Ala Val Phe Thr Val Glu Ile Val 
        835                 840                 845             


Leu Lys Met Thr Thr Tyr Gly Ala Phe Leu His Lys Gly Ser Phe Cys 
    850                 855                 860                 


Arg Asn Tyr Phe Asn Ile Leu Asp Leu Leu Val Val Ala Val Ser Leu 
865                 870                 875                 880 


Ile Ser Met Gly Leu Glu Ser Ser Ala Ile Ser Val Val Lys Ile Leu 
                885                 890                 895     


Arg Val Leu Arg Val Leu Arg Pro Leu Arg Ala Ile Asn Arg Ala Lys 
            900                 905                 910         


Gly Leu Lys His Val Val Gln Cys Val Phe Val Ala Ile Arg Thr Ile 
        915                 920                 925             


Gly Asn Ile Val Leu Val Thr Thr Leu Leu Gln Phe Met Phe Ala Cys 
    930                 935                 940                 


Ile Gly Val Gln Leu Phe Lys Gly Lys Phe Tyr Ser Cys Asn Asp Leu 
945                 950                 955                 960 


Ser Lys Met Thr Glu Glu Glu Cys Arg Gly Tyr Tyr Tyr Ile Tyr Lys 
                965                 970                 975     


Asp Gly Asp Pro Thr Gln Ile Glu Leu Arg Pro Arg Gln Trp Ile His 
            980                 985                 990         


Asn Asp Phe His Phe Asp Asn Val  Leu Ser Ala Met Met  Ser Leu Phe 
        995                 1000                 1005             


Thr Val  Ser Thr Phe Glu Gly  Trp Pro Gln Leu Leu  Tyr Lys Ala 
    1010                 1015                 1020             


Ile Asp  Ser Asn Glu Glu Asp  Thr Gly Pro Val Tyr  Asn Asn Arg 
    1025                 1030                 1035             


Val Glu  Met Ala Ile Phe Phe  Ile Ile Tyr Ile Ile  Leu Ile Ala 
    1040                 1045                 1050             


Phe Phe  Met Met Asn Ile Phe  Val Gly Phe Val Ile  Val Thr Phe 
    1055                 1060                 1065             


Gln Glu  Gln Gly Glu Thr Glu  Tyr Lys Asn Cys Glu  Leu Asp Lys 
    1070                 1075                 1080             


Asn Gln  Arg Gln Cys Val Gln  Tyr Ala Leu Lys Ala  Arg Pro Leu 
    1085                 1090                 1095             


Arg Cys  Tyr Ile Pro Lys Asn  Pro Tyr Gln Tyr Gln  Val Trp Tyr 
    1100                 1105                 1110             


Val Val  Thr Ser Ser Tyr Phe  Glu Tyr Leu Met Phe  Ala Leu Ile 
    1115                 1120                 1125             


Met Leu  Asn Thr Ile Cys Leu  Gly Met Gln His Tyr  Asn Gln Ser 
    1130                 1135                 1140             


Glu Gln  Met Asn His Ile Ser  Asp Ile Leu Asn Val  Ala Phe Thr 
    1145                 1150                 1155             


Ile Ile  Phe Thr Leu Glu Met  Val Leu Lys Leu Ile  Ala Phe Lys 
    1160                 1165                 1170             


Pro Arg  Ala Tyr Phe Gly Asp  Pro Trp Asn Val Phe  Asp Phe Leu 
    1175                 1180                 1185             


Ile Val  Ile Gly Ser Ile Ile  Asp Val Ile Leu Ser  Glu Ile Asp 
    1190                 1195                 1200             


Thr Phe  Leu Ala Ser Ser Gly  Gly Leu Tyr Cys Leu  Gly Gly Gly 
    1205                 1210                 1215             


Cys Gly  Asn Val Asp Pro Asp  Glu Ser Ala Arg Ile  Ser Ser Ala 
    1220                 1225                 1230             


Phe Phe  Arg Leu Phe Arg Val  Met Arg Leu Val Lys  Leu Leu Asn 
    1235                 1240                 1245             


Arg Ala  Glu Gly Val Arg Thr  Leu Leu Trp Thr Phe  Ile Lys Ser 
    1250                 1255                 1260             


Phe Gln  Ala Leu Pro Tyr Val  Ala Leu Leu Ile Val  Met Leu Phe 
    1265                 1270                 1275             


Phe Ile  Tyr Ala Val Ile Gly  Met Gln Met Phe Gly  Lys Ile Ala 
    1280                 1285                 1290             


Met Val  Asp Gly Thr Gln Ile  Asn Arg Asn Asn Asn  Phe Gln Thr 
    1295                 1300                 1305             


Phe Pro  Gln Ala Val Leu Leu  Leu Phe Arg Cys Ala  Thr Gly Glu 
    1310                 1315                 1320             


Ala Trp  Gln Glu Ile Leu Leu  Ala Cys Ser Tyr Gly  Lys Leu Cys 
    1325                 1330                 1335             


Asp Pro  Glu Ser Asp Tyr Ala  Pro Gly Glu Glu His  Thr Cys Gly 
    1340                 1345                 1350             


Thr Asn  Phe Ala Tyr Tyr Tyr  Phe Ile Ser Phe Tyr  Met Leu Cys 
    1355                 1360                 1365             


Ala Phe  Leu Ile Ile Asn Leu  Phe Val Ala Val Ile  Met Asp Asn 
    1370                 1375                 1380             


Phe Asp  Tyr Leu Thr Arg Asp  Trp Ser Ile Leu Gly  Pro His His 
    1385                 1390                 1395             


Leu Asp  Glu Phe Lys Ala Ile  Trp Ala Glu Tyr Asp  Pro Glu Ala 
    1400                 1405                 1410             


Lys Gly  Arg Ile Lys His Leu  Asp Val Val Thr Leu  Leu Arg Arg 
    1415                 1420                 1425             


Ile Gln  Pro Pro Leu Gly Phe  Gly Lys Phe Cys Pro  His Arg Val 
    1430                 1435                 1440             


Ala Cys  Lys Arg Leu Val Gly  Met Asn Met Pro Leu  Asn Ser Asp 
    1445                 1450                 1455             


Gly Thr  Val Thr Phe Asn Ala  Thr Leu Phe Ala Leu  Val Arg Thr 
    1460                 1465                 1470             


Ala Leu  Lys Ile Lys Thr Glu  Gly Asn Phe Glu Gln  Ala Asn Glu 
    1475                 1480                 1485             


Glu Leu  Arg Ala Ile Ile Lys  Lys Ile Trp Lys Arg  Thr Ser Met 
    1490                 1495                 1500             


Lys Leu  Leu Asp Gln Val Ile  Pro Pro Ile Gly Asp  Asp Glu Val 
    1505                 1510                 1515             


Thr Val  Gly Lys Phe Tyr Ala  Thr Phe Leu Ile Gln  Glu His Phe 
    1520                 1525                 1530             


Arg Lys  Phe Met Lys Arg Gln  Glu Glu Tyr Tyr Gly  Tyr Arg Pro 
    1535                 1540                 1545             


Lys Lys  Asp Thr Val Gln Ile  Gln Ala Gly Leu Arg  Thr Ile Glu 
    1550                 1555                 1560             


Glu Glu  Ala Ala Pro Glu Ile  His Arg Ala Ile Ser  Gly Asp Pro 
    1565                 1570                 1575             


Thr Ala  Glu Glu Glu Leu Glu  Arg Ala Met Val Glu  Ala Ala Met 
    1580                 1585                 1590             


Glu Glu  Gly Ile Phe Arg Arg  Thr Gly Gly Leu Phe  Gly Gln Val 
    1595                 1600                 1605             


Asp Asn  Phe Leu Glu Arg Thr  Asn Ser Leu Pro Pro  Val Met Ala 
    1610                 1615                 1620             


Asn Gln  Arg Pro Leu Gln Phe  Ala Glu Ile Glu Met  Glu Glu Leu 
    1625                 1630                 1635             


Glu Ser  Pro Val Phe Leu Glu  Asp Phe Pro Gln Asn  Pro Gly Thr 
    1640                 1645                 1650             


His Pro  Leu Ala Arg Ala Asn  Thr Asn Asn Ala Asn  Ala Asn Val 
    1655                 1660                 1665             


Ala Tyr  Gly Asn Ser Ser His  Arg Asn Asn Pro Val  Phe Ser Ser 
    1670                 1675                 1680             


Ile Cys  Tyr Glu Arg Glu Phe  Leu Gly Glu Ala Asp  Met Pro Val 
    1685                 1690                 1695             


Thr Arg  Glu Gly Pro Leu Ser  Gln Pro Cys Ser Gly  Ser Gly Pro 
    1700                 1705                 1710             


His Ser  Arg Ser His Val Asp  Lys Leu Lys Arg Pro  Met Thr Gln 
    1715                 1720                 1725             


Arg Gly  Met Pro Glu Gly Gln  Val Pro Pro Ser Pro  Cys Gln Leu 
    1730                 1735                 1740             


Ser Gln  Ala Glu His Pro Val  Gln Lys Glu Gly Lys  Gly Pro Thr 
    1745                 1750                 1755             


Ser Arg  Phe Leu Glu Thr Pro  Asn Ser Arg Asn Phe  Glu Glu His 
    1760                 1765                 1770             


Val Pro  Arg Asn Ser Ala His  Arg Cys Thr Ala Pro  Ala Thr Ala 
    1775                 1780                 1785             


Met Leu  Ile Gln Glu Ala Leu  Val Arg Gly Gly Leu  Asp Ser Leu 
    1790                 1795                 1800             


Ala Ala  Asp Ala Asn Phe Val  Met Ala Thr Gly Gln  Ala Leu Ala 
    1805                 1810                 1815             


Asp Ala  Cys Gln Met Glu Pro  Glu Glu Val Glu Val  Ala Ala Thr 
    1820                 1825                 1830             


Glu Leu  Leu Lys Gln Glu Ser  Pro Glu Ala Gly Pro  Cys Leu Gly 
    1835                 1840                 1845             


Ala Leu  Ser Leu Arg Ser Ser  Pro Gly Pro Pro Glu  Ser Asp Asp 
    1850                 1855                 1860             


Trp Gly  Ser Gln Thr Thr Leu  Ile Thr Pro Arg Cys  Glu Ala Tyr 
    1865                 1870                 1875             


Thr Glu  
    1880 


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cells


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Ser Gln Xaa Xaa Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr 
1               5                   10                  15      


Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu 
            20                  25                  30          


Trp Leu Gly Val Ile Trp Arg Gly Gly Asn Thr Asp Tyr Ser Ala Ala 
        35                  40                  45              


Phe Met Ser Arg Leu Ile Ile Thr Lys Asp Asn Ser Lys Ser Gln Val 
    50                  55                  60                  


Phe Phe Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr 
65                  70                  75                  80  


Cys Val Lys Lys Ala Tyr Tyr Tyr Gly Ser Asn Tyr Tyr Thr Met Asp 
                85                  90                  95      


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            100                 105             


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cells

<400>  14

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cells

<400>  15

Ile Trp Arg Gly Gly Asn Thr 
1               5           


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  16

Val Lys Lys Ala Tyr Tyr Tyr Gly Ser Asn Tyr Tyr Thr Met Asp Tyr 
1               5                   10                  15      


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  17

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  18

Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  19
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  19

Lys Val Ser 
1           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  20

Phe Gln Gly Ser His Val Pro Phe Thr 
1               5                   


<210>  21
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Lys Xaa Ser Gly Tyr Thr Phe Thr Glu Tyr Thr Met His Trp Val Lys 
1               5                   10                  15      


Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Arg Asn 
            20                  25                  30          


Asn Gly Gly Thr Tyr Tyr Asn Gln Lys Val Arg Gly Lys Ala Thr Leu 
        35                  40                  45              


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu 
    50                  55                  60                  


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala His Arg Phe Ala Tyr 
65                  70                  75                  80  


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
                85                  90      


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  22

Gly Tyr Thr Phe Thr Glu Tyr Thr 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  23

Ile Asn Arg Asn Asn Gly Gly Thr 
1               5               


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  24

Ala His Arg Phe Ala Tyr 
1               5       


<210>  25
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  25

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  26

Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe 
1               5                   10  


<210>  27
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  27

Arg Ala Ser 
1           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  28

Gln Gln Ser Asn Glu Asp Pro Phe Thr 
1               5                   


<210>  29
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  29

Gly Gly Leu Val Gln Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala 
1               5                   10                  15      


Ser Gly Phe Thr Phe Ser Ser Phe Gly Met His Trp Val Arg Gln Ala 
            20                  25                  30          


Pro Glu Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Ser 
        35                  40                  45              


Thr Ile Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg 
    50                  55                  60                  


Asp Asn Pro Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser 
65                  70                  75                  80  


Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly Val Arg Arg Pro 
                85                  90                  95      


Gly Glu Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  30

Gly Phe Thr Phe Ser Ser Phe Gly 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  31

Ile Ser Ser Gly Ser Ser Thr Ile 
1               5               


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  32

Ala Arg Arg Gly Val Arg Arg Pro Gly Glu Ala Met Asp Tyr 
1               5                   10                  


<210>  33
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Thr Xaa Ser Glu Gly Gly Pro Ser Trp Ile Xaa Asn 
            100                 105                 110 


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  34

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  35
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  35

Leu Ala Ser 
1           


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  36

Gln His Ser Arg Glu Leu His 
1               5           


<210>  37
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
1               5                   10                  15      


Thr Glu Tyr Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
            20                  25                  30          


Glu Trp Ile Gly Gly Ile Asn Arg Asn Asn Gly Gly Thr Tyr Tyr Asn 
        35                  40                  45              


Gln Lys Val Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
    50                  55                  60                  


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Xaa Gly Phe Cys Ser 
65                  70                  75                  80  


Leu 
    


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  38

Gly Tyr Thr Phe Thr Glu Tyr Thr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  39

Ile Asn Arg Asn Asn Gly Gly Thr 
1               5               


<210>  40

<400>  40
000

<210>  41
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys Xaa Asn 
            100                 105                 110 


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  42

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  43
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  43

Leu Ala Ser 
1           


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  44

Gln His Ile Arg Glu Leu Thr 
1               5           


<210>  45
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Leu Val Gln Pro Gly Xaa Xaa Leu Lys Leu Ser Cys Lys Ser Asn Glu 
1               5                   10                  15      


Tyr Glu Phe Pro Ser His Asp Met Ser Trp Val Arg Thr Thr Pro Glu 
            20                  25                  30          


Lys Arg Leu Glu Leu Val Ala Ala Ile Asn Ser Asp Gly Gly Asn Thr 
        35                  40                  45              


Tyr Tyr Pro Asp Thr Met Glu Arg Arg Phe Ile Ile Ser Arg Asp Asn 
    50                  55                  60                  


Thr Lys Lys Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp 
65                  70                  75                  80  


Thr Ala Leu Tyr Tyr Cys Ala Arg His Ser Met Val Thr Pro Asp Leu 
                85                  90                  95      


Leu Thr Gly Ala Lys Gly Leu Trp Ser Leu Ser Leu Gln 
            100                 105                 


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  46

Glu Tyr Glu Phe Pro Ser His Asp 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  47

Ile Asn Ser Asp Gly Gly Asn Thr 
1               5               


<210>  48
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  48

Ala Arg His Ser Met Val Thr Pro Asp Leu Leu 
1               5                   10      


<210>  49
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa can be any naturally occurring amino acid

<400>  49

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys Xaa Asn 
            100                 105                 110 


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  50

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  51
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  51

Leu Ala Ser 
1           


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  52

Gln His Ile Arg Glu Leu Thr Arg 
1               5               


<210>  53
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  53

Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
1               5                   10                  15      


Thr Asp Tyr Thr Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
            20                  25                  30          


Glu Trp Ile Gly Val Ile Ser Ser Tyr Ser Gly Asn Thr Asn Tyr Asn 
        35                  40                  45              


Gln Lys Phe Glu Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
    50                  55                  60                  


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
65                  70                  75                  80  


Tyr Tyr Cys Ala Arg His 
                85      


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  54

Gly Tyr Thr Phe Thr Asp Tyr Thr 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  55

Ile Ser Ser Tyr Ser Gly Asn Thr 
1               5               


<210>  56

<400>  56
000

<210>  57
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  57

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  58

Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr 
1               5                   10      


<210>  59
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  59

Leu Val Ser 
1           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  60

Trp Gln Gly Thr His Phe Pro Phe Thr 
1               5                   


<210>  61
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  61

Leu Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly 
1               5                   10                  15      


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu 
            20                  25                  30          


Lys Arg Leu Glu Trp Val Ala Ser Ile Ser Ser Gly Gly Ser Thr Tyr 
        35                  40                  45              


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    50                  55                  60                  


Arg Asn Ile Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
65                  70                  75                  80  


Ala Met Tyr Tyr Cys Ala Arg Leu Gly Asp Gly Tyr Tyr Pro Phe Ala 
                85                  90                  95      


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105             


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  62

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  63

Ile Ser Ser Gly Gly Ser Thr 
1               5           


<210>  64
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  64

Ala Arg Leu Gly Asp Gly Tyr Tyr Pro Phe Ala Tyr 
1               5                   10          


<210>  65

<400>  65
000

<210>  66

<400>  66
000

<210>  67
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  67

Ala Ala Ala Ala Ala Ala 
1               5       


<210>  68
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  68

Ala Ala Ala Ala Ala Ala Ala Ala 
1               5               


<210>  69
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  69

Lys Gly Xaa Gly Tyr Thr Phe Thr Asp Tyr Thr Met His Trp Val Lys 
1               5                   10                  15      


Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly Val Ile Ser Ser Tyr 
            20                  25                  30          


Ser Gly Asn Thr Asn Tyr Asn Gln Lys Phe Glu Gly Lys Ala Thr Met 
        35                  40                  45              


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Ala Arg Leu 
    50                  55                  60                  


Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys Ala Arg His Tyr Gly Tyr 
65                  70                  75                  80  


Asp Val Thr Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
                85                  90                  95  


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  70

Gly Tyr Thr Phe Thr Asp Tyr Thr 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  71

Ile Ser Ser Tyr Ser Gly Asn Thr 
1               5               


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  72

Ala Arg His Tyr Gly Tyr Asp Val Thr Phe 
1               5                   10  


<210>  73
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa can be any naturally occurring amino acid

<400>  73

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Xaa Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Xaa Ala Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105         


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  74

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  75
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  75

Leu Ala Ser 
1           


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  76

Gln His Ile Arg Glu Leu Thr Arg 
1               5               


<210>  77
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  77

Leu Val Gln Pro Gly Gly Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly 
1               5                   10                  15      


Phe Thr Phe Ser Asn Phe Gly Met His Trp Val Arg Gln Ala Pro Glu 
            20                  25                  30          


Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Ser Gly Ser Asn Thr Ile 
        35                  40                  45              


Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    50                  55                  60                  


Gly Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp 
65                  70                  75                  80  


Thr Ala Ile Tyr Tyr Cys Ala Ser Tyr Gly Asn Tyr Ala Ala Tyr Trp 
                85                  90                  95      


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
            100                 105     


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  78

Gly Phe Thr Phe Ser Asn Phe Gly 
1               5               


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  79

Ile Ser Ser Gly Ser Asn Thr Ile 
1               5               


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  80

Ala Ser Tyr Gly Asn Tyr Ala Ala Tyr 
1               5                   


<210>  81
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa can be any naturally occurring amino acid

<400>  81

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Xaa Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Xaa Ala Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105         


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  82

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  83
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  83

Leu Ala Ser 
1           


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  84

Gln His Ile Arg Xaa Ala Tyr Thr 
1               5               


<210>  85
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<400>  85

Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly 
1               5                   10                  15      


Val Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly 
            20                  25                  30          


Ile Ile Trp Gly Gly Gly Ser Thr Tyr Tyr Asn Ser Val Leu Lys Ser 
        35                  40                  45              


Arg Leu Ser Ile Asn Lys Asp Asn Xaa Lys Ser Gln Val Phe Leu Lys 
    50                  55                  60                  


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
65                  70                  75                  80  


His Arg Gly Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
                85                  90                  95  


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  86

Gly Phe Ser Leu Thr Asp Tyr Gly 
1               5               


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  87

Ile Trp Gly Gly Gly Ser Thr 
1               5           


<210>  88
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  88

Ala Lys His Arg Gly Asp 
1               5       


<210>  89
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<400>  89

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Xaa Ala Ala Xaa Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys 
            100                 105             


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  90

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  91
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  91

Leu Ala Ser 
1           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  92

Ser Thr Leu Gly Ser Leu His 
1               5           


<210>  93

<400>  93
000

<210>  94

<400>  94
000

<210>  95

<400>  95
000

<210>  96

<400>  96
000

<210>  97
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line


<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa can be any naturally occurring amino acid

<400>  97

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Xaa Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys Xaa Asn 
            100                 105                 110 


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  98

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  99
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  99

Leu Ala Ser 
1           


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  100

Gln His Ile Arg Glu Leu Thr 
1               5           


<210>  101

<400>  101
000

<210>  102

<400>  102
000

<210>  103

<400>  103
000

<210>  104

<400>  104
000

<210>  105
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  105

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys 
            100                 105             


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  106

Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr 
1               5                   10  


<210>  107
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  107

Leu Ala Ser 
1           


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Produced from hybridoma cell line

<400>  108

Cys Gln His Ile Arg Glu Leu Thr Arg 
1               5                   


