                         SEQUENCE LISTING

<110>  Idera Pharmaceuticals, Inc.
       AGRAWAL, Sudhir
       WANG, Daqing
       ZHU, Fu-Gang
 
<120>  TOLL-LIKE RECEPTOR 9 ANTAGONIST AND METHODS OF USE THEREOF

<130>  4204.3001 WO

<140>  PCT/US2016/017590
<141>  2016-02-11

<150>  62/115,753
<151>  2015-02-13

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N = A,T,C or G

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  C is a nitrogenous base selected from the group consisting of 
       cytosine, 5-methyl-2'-deoxycytosine and 2'-O-methylcytosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  G is a nitrogenous base selected from the group consisting of 
       guanine, 5-methyl-2'-deoxyguanosine and 2'-O-methylguanine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  N = A,T,C or G

<400>  1
ncgn                                                                     4


<210>  2
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  N = A, T, C or G

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  C is a nitrogenous base selected from the group consisting of 
       cytosine, 5-methyl-2'-deoxycytosine and 2'-O-methylcytosine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  G is a nitrogenous base selected from the group consisting of 
       guanine, 5-methyl-2'-deo

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  N = A, T, C or G

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  C is a nitrogenous base selected from the group consisting of 
       cytosine, 5-methyl-2'-deoxycytosine and 2'-O-methylcytosine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  G is a nitrogenous base selected from the group consisting of 
       guanine, 5-methyl-2'-deo

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  N = A, T, C or G

<400>  2
ncgncgn                                                                  7


<210>  3
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxyguanosine or 2'-deoxyguanosine methylphosphonate

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  C is a nitrogenous base selected from the group consisting of 
       cytosine, 5-methyl-2'-deoxycytosine and 2'-O-methylcytosine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  G is a nitrogenous base selected from the group consisting of 
       guanine, 5-methyl-2'-deoxyguanosine and 2'-O-methylguanine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  C is a nitrogenous base selected from the group consisting of 
       cytosine, 5-methyl-2'-deoxycytosine and 2'-O-methylcytosine

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  G is a nitrogenous base selected from the group consisting of 
       guanine, 5-methyl-2'-deoxyguanosine and 2'-O-methylguanine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2'-deoxyguanosine or 2'-deoxyguanosine methylphosphonate

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2'-deoxycytosine

<400>  3
gtcgnccgca gn                                                           12


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<400>  4
gtcgcccctt ctccccgcag                                                   20


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<400>  5
gtcgcccctt ctccccgcag c                                                 21


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  2'-deoxyguanosine methylphosphonate

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  2'-deoxyguanosine methylphosphonate

<400>  6
gtcgcccctt ctccccgcag                                                   20


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  G = 2'-deoxyguanosine methylphosphonate

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  G = 2'-deoxyguanosine methylphosphonate

<400>  7
gtcgcccctt ctccccgcag c                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<400>  8
gtcgtttacc tcttccgcag c                                                 21


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
gtcgcccctt ctccccgcag                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
gtcgcccctt ctccccgcag c                                                 21


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  G = 2'-O-Me-G

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  U = 2'-O-Me-U

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  G =7-deaza-dG

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  C = 5-methyl 2'-deoxycytidine 5'-monophosphate

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  G = 2'-O-Me-G

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  U = 2'-O-Me-U

<400>  11
ctatctgucg ttctctgu                                                     18


