                         SEQUENCE LISTING

<110>  Rowan University
 
<120>  Early Stage Parkinson's Disease Diagnostic Kits and Methods

<130>  125107.00062

<150>  62/114,971
<151>  2015-02-11

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  5336
<212>  DNA
<213>  Homo sapiens

<400>  1
gctgctccgc gcgcagccgg ctcgggccgc tcctcctgac tgaggcgcgg cggcggcggt       60

ggctgtgacc gcgcggaccg agccgagaca ttcgcgccgg gggatcgggc gccgccgccg      120

ctgggccccg ggcgcgtgga tgcggctggg tcgggcggcg ccgtacacct gaggcggaga      180

acggggcgcg gcgcgggtga cgctgtcagg gccgcggttc ctgacgccca ggcgctcgcc      240

aggacgagcc aggcagtgat ttgaggcacc ggcttcacct tcacccatgg tccggagagc      300

ctagcggggc tcgccaccgc ctcccggctc cccttccacg cctcatcctg ccagcctcgc      360

cgccccgcca gcgccgggca accgcctcgc ccgaagccct ccctcgttac tgtccgcata      420

ccccggcggc gccgccgcgg gaagcggctc cccctcctct tcctccgcgt cctcttccct      480

ctttcccccg ccggggccgc ttgttgcacc gccccgcggc ctgcgggagc cgctcgcccc      540

ggccttgtgc tcgcgtccgc acccctttcc tgtcgccccc cggggcccgc accacagccc      600

ggccggcgag accccggcca gaccccgctg cccgcacaaa atgtcggccc ggacgccatt      660

gccgacggtg aacgagcggg acacggaaaa tcatacatct gtggatggat atactgaacc      720

acacatccag cctaccaagt cgagtagcag acagaacatc ccccggtgta gaaactccat      780

tacgtcagca acagatgaac agcctcacat tggaaattac cgtttacaaa aaacaatagg      840

gaagggaaat tttgccaaag tcaaattggc aagacacgtt ctaactggta gagaggttgc      900

tgtgaaaata atagacaaaa ctcagctaaa tcctaccagt ctacaaaagt tatttcgaga      960

agtacgaata atgaagatac tgaatcatcc taatatagta aaattgtttg aagttattga     1020

aacagagaag actctctatt tagtcatgga atacgcgagt gggggtgaag tatttgatta     1080

cttagttgcc catggaagaa tgaaagagaa agaggcccgt gcaaaattta ggcagattgt     1140

atctgctgta cagtattgtc atcaaaagta cattgttcac cgtgatctta aggctgaaaa     1200

ccttctcctt gatggtgata tgaatattaa aattgctgac tttggtttta gtaatgaatt     1260

tacagttggg aacaaattgg acacattttg tggaagccca ccctatgctg ctcccgagct     1320

tttccaagga aagaagtatg atgggcctga agtggatgtg tggagtctgg gcgtcattct     1380

ctatacatta gtcagtggct ccttgccttt cgatggccag aatttaaagg aactgcgaga     1440

gcgagtttta cgagggaagt accgtattcc cttctatatg tccacagact gtgaaaatct     1500

tctgaagaaa ttattagtcc tgaatccaat aaagagaggc agcttggaac aaataatgaa     1560

agatcgatgg atgaatgttg gtcatgaaga ggaagaacta aagccatata ctgagcctga     1620

tccggatttc aatgacacaa aaagaataga cattatggtc accatgggct ttgcacgaga     1680

tgaaataaat gatgccttaa taaatcagaa gtatgatgaa gttatggcta cttatattct     1740

tctaggtaga aaaccacctg aatttgaagg tggtgaatcg ttatccagtg gaaacttgtg     1800

tcagaggtcc cggcccagta gtgacttaaa caacagcact cttcagtccc ctgctcacct     1860

gaaggtccag agaagtatct cagcaaatca gaagcagcgg cgtttcagtg atcatgctgg     1920

tccatccatt cctcctgctg tatcatatac caaaagacct caggctaaca gtgtggaaag     1980

tgaacagaaa gaggagtggg acaaagatgt ggctcgaaaa cttggcagca caacagttgg     2040

atcaaaaagc gagatgactg caagccctct tgtagggcca gagaggaaaa aatcttcaac     2100

tattccaagt aacaatgtgt attctggagg tagcatggca agaaggaata catatgtctg     2160

tgaaaggacc acagatcgat acgtagcatt gcagaatgga aaagacagca gccttacgga     2220

gatgtctgtg agtagcatat cttctgcagg ctcttctgtg gcctctgctg tcccctcagc     2280

acgaccccgc caccagaagt ccatgtccac ttctggtcat cctattaaag tcacactgcc     2340

aaccattaaa gacggctctg aagcttaccg gcctggtaca acccagagag tgcctgctgc     2400

ttccccatct gctcacagta ttagtactgc gactccagac cggacccgtt ttccccgagg     2460

gagctcaagc cgaagcactt tccatggtga acagctccgg gagcgacgca gcgttgctta     2520

taatgggcca cctgcttcac catcccatga aacgggtgca tttgcacatg ccagaagggg     2580

aacgtcaact ggtataataa gcaaaatcac atccaaattt gttcgcaggg atccaagtga     2640

aggcgaagcc agtggcagaa ccgacacctc aagaagtaca tcaggggaac caaaagaaag     2700

agacaaggaa gagggtaaag attctaagcc gcgttctttg cggttcacat ggagtatgaa     2760

gaccactagt tcaatggacc ctaatgacat gatgagagaa atccgaaaag tgttagatgc     2820

aaataactgt gattatgagc aaaaagagag atttttgctt ttctgtgtcc atggagacgc     2880

tagacaggat agcctcgtgc agtgggagat ggaagtctgc aagttgccac gactgtcact     2940

taatggggtt cgcttcaagc gaatatctgg gacatctatt gcctttaaga acattgcatc     3000

aaaaatagca aatgagctta agctgtaaag aagtccaaat ttacaggttc agggaagata     3060

catacatata tgaggtacag tttttgaatg tactggtaat gcctaatgtg gtctgcctgt     3120

gaatctcccc atgtagaatt tgcccttaat gcaataaggt tatacatagt tatgaactgt     3180

aaaattaaag tcagtatgaa ctataataaa tatctgtagc ttaaaaagta ggttcacatg     3240

tacaggtaag tatattgtgt atttctgttc attttctgtt catagagttg tataataaaa     3300

catgattgct taaaaacttg tatagttgtc tagatttctg cacctgaatg tatgtttgat     3360

gctttgattt gaaaatgttc ttccctgtta tttacattct ggtgggtttt taaaattctt     3420

acctccatca tgcaattttg aaaattgtgt ccagaattaa aagtgcatag aaatagcctt     3480

tacaattgta gcatggacct ttaaaaattg ttttaaaatc ttatttaaat ttaaaccaga     3540

agctgaaaaa tagatcagct ttattataca caaaattatt actgcttatc tttgctcttt     3600

tccttgttat cccgcaaggt ttagttgaga agatacaaaa tgtttacagt gttggcactt     3660

agagttttta aattcaagta catgaaattc agtaatagca ttgccttgag ctaactagga     3720

agtaccggga aaaaagttaa atctacatca agtttctttt gaactttgaa gtgttttctg     3780

acccactgct aactgtagca acaaaattta aaagaaaaaa aacatacttt atctggctat     3840

tataacataa actgtcacgt aggtttgctg ccttcagaat accgcaattt aattgcggga     3900

atataataat attgggactg tttcacagca caaactcatc tttacagtgt tgatcaatgc     3960

atcagttaag aaataatgcc acctcaggaa ttaactggca ttgggaacat ttgcctcatt     4020

ctcctgctat cctcttcatt cacccctgcc actgtaatat ctataagtac ttaagagact     4080

tgtgagcaaa acatactatt tataacagta tatgattgat ttatgcttat gtggttgttc     4140

agtttgttcc catgtaactc gtttgtttta aatattttgc cagatttctt gtatttattc     4200

cacatcatta tgcctataat gtgccgcttt gtgattgggc atttgcctac ttttctttca     4260

taattagtga tatatgcgat gtaaaaccac tagtaaaggt acattttaat acttgttatt     4320

ttatactgaa ttagccttgg aggttgactg tgcaatgtta tttactgttg taattactgt     4380

aataccaaca tatgggcccc atctgcacac tcctgaaaaa cagaaagtgt attcaaattt     4440

tatcagttta aagaaaataa agctgtgata aatactgtaa ttccaaccta cattagaagg     4500

tctaagtgta ggtgatgtgc cattccataa tggcttccag actagggtga attttatgtt     4560

ctgtactgta ctgtgatgta gctttcttct gtaacagtta tgttttaaaa ttaagtgagt     4620

tttttttttg ccttagcaaa gggtggtgtt tgaaaaaaaa aatgtgtagc ccctttttaa     4680

cctagtgttc attcaaaaaa aaattgatgc aaatctttat tcactttcac tggtgcacac     4740

tgaaatttta cttgaacagt tctcataata aagcacttgt cttttgctct ttatcagaat     4800

gtgaattacc tgttttctgg tacaaaagta ttctgtatga ggagtttatt gtatgtgttc     4860

taaatttagt tggcaaaggg tgaagctgtg aaggttttca agattattga aactatgaag     4920

gtttcttgtc attatgacaa gaaagtttaa tctttttata ggaattcctg tcactgaaat     4980

acgtttttaa aaaaatagac tcatgtgttt tccacggtag aaactgatat ttttttacat     5040

tttctcactg tggccaactc ttctgtgttt gtagaaagga atttgacttc aatatctttt     5100

atgaactaaa aatgaaatct tgatactcac tttagatttt tcattttatg tgttcatgac     5160

aacataaata tttttcaaag atttagagga attttgcaat gtgtttgcat aaataaatac     5220

cagtttatgt tcaccggcta tgtgatacca ggatttcctt ggcttctgtt gaaatattat     5280

ttgatatgac atcccttata ttaaattaat tattttgtaa aaaaaaaaaa aaaaaa         5336


<210>  2
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ala Arg Thr Pro Leu Pro Thr Val Asn Glu Arg Asp Thr Glu 
1               5                   10                  15      


Asn His Thr Ser Val Asp Gly Tyr Thr Glu Pro His Ile Gln Pro Thr 
            20                  25                  30          


Lys Ser Ser Ser Arg Gln Asn Ile Pro Arg Cys Arg Asn Ser Ile Thr 
        35                  40                  45              


Ser Ala Thr Asp Glu Gln Pro His Ile Gly Asn Tyr Arg Leu Gln Lys 
    50                  55                  60                  


Thr Ile Gly Lys Gly Asn Phe Ala Lys Val Lys Leu Ala Arg His Val 
65                  70                  75                  80  


Leu Thr Gly Arg Glu Val Ala Val Lys Ile Ile Asp Lys Thr Gln Leu 
                85                  90                  95      


Asn Pro Thr Ser Leu Gln Lys Leu Phe Arg Glu Val Arg Ile Met Lys 
            100                 105                 110         


Ile Leu Asn His Pro Asn Ile Val Lys Leu Phe Glu Val Ile Glu Thr 
        115                 120                 125             


Glu Lys Thr Leu Tyr Leu Val Met Glu Tyr Ala Ser Gly Gly Glu Val 
    130                 135                 140                 


Phe Asp Tyr Leu Val Ala His Gly Arg Met Lys Glu Lys Glu Ala Arg 
145                 150                 155                 160 


Ala Lys Phe Arg Gln Ile Val Ser Ala Val Gln Tyr Cys His Gln Lys 
                165                 170                 175     


Tyr Ile Val His Arg Asp Leu Lys Ala Glu Asn Leu Leu Leu Asp Gly 
            180                 185                 190         


Asp Met Asn Ile Lys Ile Ala Asp Phe Gly Phe Ser Asn Glu Phe Thr 
        195                 200                 205             


Val Gly Asn Lys Leu Asp Thr Phe Cys Gly Ser Pro Pro Tyr Ala Ala 
    210                 215                 220                 


Pro Glu Leu Phe Gln Gly Lys Lys Tyr Asp Gly Pro Glu Val Asp Val 
225                 230                 235                 240 


Trp Ser Leu Gly Val Ile Leu Tyr Thr Leu Val Ser Gly Ser Leu Pro 
                245                 250                 255     


Phe Asp Gly Gln Asn Leu Lys Glu Leu Arg Glu Arg Val Leu Arg Gly 
            260                 265                 270         


Lys Tyr Arg Ile Pro Phe Tyr Met Ser Thr Asp Cys Glu Asn Leu Leu 
        275                 280                 285             


Lys Lys Leu Leu Val Leu Asn Pro Ile Lys Arg Gly Ser Leu Glu Gln 
    290                 295                 300                 


Ile Met Lys Asp Arg Trp Met Asn Val Gly His Glu Glu Glu Glu Leu 
305                 310                 315                 320 


Lys Pro Tyr Thr Glu Pro Asp Pro Asp Phe Asn Asp Thr Lys Arg Ile 
                325                 330                 335     


Asp Ile Met Val Thr Met Gly Phe Ala Arg Asp Glu Ile Asn Asp Ala 
            340                 345                 350         


Leu Ile Asn Gln Lys Tyr Asp Glu Val Met Ala Thr Tyr Ile Leu Leu 
        355                 360                 365             


Gly Arg Lys Pro Pro Glu Phe Glu Gly Gly Glu Ser Leu Ser Ser Gly 
    370                 375                 380                 


Asn Leu Cys Gln Arg Ser Arg Pro Ser Ser Asp Leu Asn Asn Ser Thr 
385                 390                 395                 400 


Leu Gln Ser Pro Ala His Leu Lys Val Gln Arg Ser Ile Ser Ala Asn 
                405                 410                 415     


Gln Lys Gln Arg Arg Phe Ser Asp His Ala Gly Pro Ser Ile Pro Pro 
            420                 425                 430         


Ala Val Ser Tyr Thr Lys Arg Pro Gln Ala Asn Ser Val Glu Ser Glu 
        435                 440                 445             


Gln Lys Glu Glu Trp Asp Lys Asp Val Ala Arg Lys Leu Gly Ser Thr 
    450                 455                 460                 


Thr Val Gly Ser Lys Ser Glu Met Thr Ala Ser Pro Leu Val Gly Pro 
465                 470                 475                 480 


Glu Arg Lys Lys Ser Ser Thr Ile Pro Ser Asn Asn Val Tyr Ser Gly 
                485                 490                 495     


Gly Ser Met Ala Arg Arg Asn Thr Tyr Val Cys Glu Arg Thr Thr Asp 
            500                 505                 510         


Arg Tyr Val Ala Leu Gln Asn Gly Lys Asp Ser Ser Leu Thr Glu Met 
        515                 520                 525             


Ser Val Ser Ser Ile Ser Ser Ala Gly Ser Ser Val Ala Ser Ala Val 
    530                 535                 540                 


Pro Ser Ala Arg Pro Arg His Gln Lys Ser Met Ser Thr Ser Gly His 
545                 550                 555                 560 


Pro Ile Lys Val Thr Leu Pro Thr Ile Lys Asp Gly Ser Glu Ala Tyr 
                565                 570                 575     


Arg Pro Gly Thr Thr Gln Arg Val Pro Ala Ala Ser Pro Ser Ala His 
            580                 585                 590         


Ser Ile Ser Thr Ala Thr Pro Asp Arg Thr Arg Phe Pro Arg Gly Ser 
        595                 600                 605             


Ser Ser Arg Ser Thr Phe His Gly Glu Gln Leu Arg Glu Arg Arg Ser 
    610                 615                 620                 


Val Ala Tyr Asn Gly Pro Pro Ala Ser Pro Ser His Glu Thr Gly Ala 
625                 630                 635                 640 


Phe Ala His Ala Arg Arg Gly Thr Ser Thr Gly Ile Ile Ser Lys Ile 
                645                 650                 655     


Thr Ser Lys Phe Val Arg Arg Asp Pro Ser Glu Gly Glu Ala Ser Gly 
            660                 665                 670         


Arg Thr Asp Thr Ser Arg Ser Thr Ser Gly Glu Pro Lys Glu Arg Asp 
        675                 680                 685             


Lys Glu Glu Gly Lys Asp Ser Lys Pro Arg Ser Leu Arg Phe Thr Trp 
    690                 695                 700                 


Ser Met Lys Thr Thr Ser Ser Met Asp Pro Asn Asp Met Met Arg Glu 
705                 710                 715                 720 


Ile Arg Lys Val Leu Asp Ala Asn Asn Cys Asp Tyr Glu Gln Lys Glu 
                725                 730                 735     


Arg Phe Leu Leu Phe Cys Val His Gly Asp Ala Arg Gln Asp Ser Leu 
            740                 745                 750         


Val Gln Trp Glu Met Glu Val Cys Lys Leu Pro Arg Leu Ser Leu Asn 
        755                 760                 765             


Gly Val Arg Phe Lys Arg Ile Ser Gly Thr Ser Ile Ala Phe Lys Asn 
    770                 775                 780                 


Ile Ala Ser Lys Ile Ala Asn Glu Leu Lys Leu 
785                 790                 795 


<210>  3
<211>  1262
<212>  DNA
<213>  Homo sapiens

<400>  3
cgcctctgac gccaccggct gggctccgcc atgagttcgg cgccggcctc aggctccgtg       60

cgcgcgcgct atcttgtgta cttccagtac gtgggcaccg actttaacgg ggtcgcggcc      120

gtcaggggca ctcagcgcgc cgtcggggtc cagaactacc tggaggaggc cgccgagcgg      180

ctgaattccg tggagccggt caggttcacc atctccagcc gcacggacgc cggggtccac      240

gccctgagca acgcggcgca cctggacgtc cagcgccgct caggccggcc gcccttcccg      300

cccgaggtcc tggccgaggc cctcaacaca cacctgcggc acccggccat cagggtcctg      360

cgggccttcc gagtgcccag cgacttccac gctcgtcacg cagccacgtc ccggacctac      420

ctgtaccgcc tggccactgg ctgtcaccgg cgtgatgagc tgccggtgtt tgaacgcaac      480

ctatgctgga ctctcccggc agactgcctg gatatggtcg ccatgcagga agccgcccag      540

cacctcctcg gcacacacga cttcagcgcc ttccagtccg ctggcagccc ggtgccgagc      600

cccgtgcgaa cgctgcgccg ggtctccgtt tccccaggcc aagccagccc cttggtcacc      660

cccgaggaga gcaggaagct gcggttctgg aacctggagt ttgagagcca gtctttcctg      720

tatagacagg tacggaggat gacggctgtg ctggtggccg tggggctggg ggctttggca      780

cctgcccagg tgaagacgat tctggagagc caagatcccc tgggcaagca ccagacacgt      840

gtagccccag cccacggctt attcctcaag tcagtgctgt acgggaacct cggtgctgcc      900

tcctgcaccc tgcaggggcc acagttcggg agccacggat gaccctggac actcaagcca      960

aagttaggcc acaccaggcc caaccctgtg ctggtcaagc cagggcagtc acagctgctt     1020

ggggcccaca gcactgctgc ctggtctcca cagtagcctc cctgcccggg tcccagcacc     1080

ctggatgccc gtctctgtcc caggcgggat ggggcacagt gcaggacaca gccatgtaca     1140

ccaagaagag agtaccaagt agtcttttgt tcagctttta ctggaaactg ctgtctagga     1200

ccacctgccc taaccaggaa taaaggcaag acagcctgga aaaaaaaaaa aaaaaaaaaa     1260

aa                                                                    1262


<210>  4
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ser Ala Pro Ala Ser Gly Ser Val Arg Ala Arg Tyr Leu Val 
1               5                   10                  15      


Tyr Phe Gln Tyr Val Gly Thr Asp Phe Asn Gly Val Ala Ala Val Arg 
            20                  25                  30          


Gly Thr Gln Arg Ala Val Gly Val Gln Asn Tyr Leu Glu Glu Ala Ala 
        35                  40                  45              


Glu Arg Leu Asn Ser Val Glu Pro Val Arg Phe Thr Ile Ser Ser Arg 
    50                  55                  60                  


Thr Asp Ala Gly Val His Ala Leu Ser Asn Ala Ala His Leu Asp Val 
65                  70                  75                  80  


Gln Arg Arg Ser Gly Arg Pro Pro Phe Pro Pro Glu Val Leu Ala Glu 
                85                  90                  95      


Ala Leu Asn Thr His Leu Arg His Pro Ala Ile Arg Val Leu Arg Ala 
            100                 105                 110         


Phe Arg Val Pro Ser Asp Phe His Ala Arg His Ala Ala Thr Ser Arg 
        115                 120                 125             


Thr Tyr Leu Tyr Arg Leu Ala Thr Gly Cys His Arg Arg Asp Glu Leu 
    130                 135                 140                 


Pro Val Phe Glu Arg Asn Leu Cys Trp Thr Leu Pro Ala Asp Cys Leu 
145                 150                 155                 160 


Asp Met Val Ala Met Gln Glu Ala Ala Gln His Leu Leu Gly Thr His 
                165                 170                 175     


Asp Phe Ser Ala Phe Gln Ser Ala Gly Ser Pro Val Pro Ser Pro Val 
            180                 185                 190         


Arg Thr Leu Arg Arg Val Ser Val Ser Pro Gly Gln Ala Ser Pro Leu 
        195                 200                 205             


Val Thr Pro Glu Glu Ser Arg Lys Leu Arg Phe Trp Asn Leu Glu Phe 
    210                 215                 220                 


Glu Ser Gln Ser Phe Leu Tyr Arg Gln Val Arg Arg Met Thr Ala Val 
225                 230                 235                 240 


Leu Val Ala Val Gly Leu Gly Ala Leu Ala Pro Ala Gln Val Lys Thr 
                245                 250                 255     


Ile Leu Glu Ser Gln Asp Pro Leu Gly Lys His Gln Thr Arg Val Ala 
            260                 265                 270         


Pro Ala His Gly Leu Phe Leu Lys Ser Val Leu Tyr Gly Asn Leu Gly 
        275                 280                 285             


Ala Ala Ser Cys Thr Leu Gln Gly Pro Gln Phe Gly Ser His Gly 
    290                 295                 300             


<210>  5
<211>  6634
<212>  DNA
<213>  Homo sapiens

<400>  5
taaataatgg gaagcctttc aacttgaaac aggctcctag gagaccagaa gcagcagcct       60

ttcctgagct caggtaagag atcttaccct ctactgacac tgctcacgtt gttgtgagga      120

tcacctactt ctcctaatca tttacccagg tatgttcaag gtcacatcta aaggaccctt      180

ttccacgagg acaaaatctc tttgaggaca aataatcatc atgtttatct ttgtacttca      240

gtacctagca caacattcaa gacagcgggt gctcattaaa tgctcatcaa attgttagtt      300

caggacaact aacatcaatc tctacttaaa atgaattgat cacttgctct gtgctaagtg      360

tataaatcat agattattgt atttaaataa tcgatttaaa atcaaaacaa tttctgggtt      420

aagtttaatt atcaccattt tggggttaag aaaattaaac tcagaggtga gttgacttgt      480

ccaaggtcac atagaggtag ggtggccaac tcattccagt ttacctgtgg tttttccagt      540

tttaaaactg aaattttcgt atttcaggaa ccattccctg ccccccaacc tcagtcctgg      600

gtaaactgga atgacccaca tcaatggaaa ctagtaaagc gaggatttat ttggacccag      660

ttctcttgtc tccaaaccca gagtcctctt tgattctttt gggtttggtt tgcttttttc      720

cttttcctac atttgacagt atctcgagtg gtcacaaatg taaaaaatgt ctagcatatt      780

gcctggcata taggaaaaat tcagtaagtg ataatgatta tcagtgctgt gccaagctat      840

ggagccagcc atatatatat ggatgtgtgc atatatatat atgatgtgtg tgtatatata      900

tatgtcttta taaattttat gtatttattt ctttcaaaaa tattaaagta tttgagaaaa      960

ttgaaaaatt aaaaagtagg tttattacga ctcatgactt taagtttaaa tattttattt     1020

ctgccccaaa caaaatttat tataatttta ctgtcctggt tttaagggaa ggaaactcat     1080

caataatatt ttcatcatat gcttttgaga aacaaagtta accattaaga atgaaacatg     1140

aaaacatgtg aatagtggta caaatttttc cttttgcttc aatatggctc agcatggcac     1200

tgtcgaattt tgtctttata taaaattttg atattttgtt tgtcataagc tttttaattc     1260

atttttatat tgcactaaaa tatttttatc ttgatgactg aggtttttta gtgctccctt     1320

aaattttgca cctaaaatga gtgcctcaat tgttttaccc taacctcagc ccattattat     1380

tttatcttaa aactcagcaa acaccctaac ctgctctctt actgaggagg ctcgcccaag     1440

aataaatgag ttccgtcatt gcctttcttc tctgactttt gggaccattt gcttggtcta     1500

ggacctgagt tgcaggtcca ggaaagcgtg tactctcgaa tccacccagg agtgcctgac     1560

tacagtcctc ctgcagaggg cgctgtggag tcccagacac gagtgttagg tggaatcggg     1620

ctgattgccc atcacgtctt gcctttccct ggcagtaggc ttgttatgaa atcattgact     1680

ttctatttgc ctctggggct taagcgaatc tgttaccctc aaataaccta tctgatctca     1740

gacaaatgcc aaacagagct cagtttctct gccctgtggg tggccataaa atccagacaa     1800

tttcccccta ggtgttttcg atggcgcagc cacagcttct gtgagattcg atttctcccc     1860

agttcccctg tgggtctgag gggaccagaa gggtgagcta cgttggcttt ctggaagggg     1920

aggctatatg cgtcaattcc ccaaaacaag ttttgacatt tcccctgaaa tgtcattctc     1980

tatctattca ctgcaagtgc ctgctgttcc aggccttacc tgctgggcac taacggcgga     2040

gccaggatgg ggacagaata aaggagccac gacctgtgcc accaactcgc actcagactc     2100

tgaactcaga cctgaaatct tctcttcacg ggaggcttgg cagtttttct tagtaagttg     2160

cgtggatggg ccacactgtc tgaggccaga taaggctgtt ctcttcccct gaccccccac     2220

ccctcacccc gtggacactt ggaggagggg aaactcagta agtcatgctc tcttctttga     2280

attcctagct cctgtggtct ccagatttca ggcctaagat gaaagcctct agtcttgcct     2340

tcagccttct ctctgctgcg ttttatctcc tatggactcc ttccactgga ctgaagacac     2400

tcaatttggg aagctgtgtg atcgccacaa accttcagga aatacgaaat ggattttctg     2460

agatacgggg cagtgtggta cgtaagcggg tatctacctc tcctgaaagc cttttctctt     2520

ccttccttgt ccgtttctct ttcctggcag tactggcagt gtaatcataa aaagaggcag     2580

gctggggatt ccttacccgg gggatgtatt ccaaagaaat aactgtagtt caaatattta     2640

aaatgttttg ggaaaggaca cctcccacta gttcttggca gggagtggat gagaagtctt     2700

gatattgaag accctggcag caggcactga ctcatccttg cttgttttgt cttcttctgt     2760

ttagcaagcc aaagatggaa acattgacat cagaatctta aggaggactg agtctttgca     2820

agacacaaag gtatgtgctt ggcccagaca aactctggga ggaggagtgg agtgggagca     2880

tctccatcac cctggtcttg tctctgctct cccctttccc ctcaccaata tacctgtggt     2940

tttttgcagc ctgcgaatcg atgctgcctc ctgcgccatt tgctaagact ctatctggac     3000

agggtattta aaaactacca gacccctgac cattatactc tccggaagat cagcagcctc     3060

gccaattcct ttcttaccat caagaaggac ctccggctct gtgtgagtgt gggtcttggg     3120

tgacaggatg catctcagca cacagcttca atggcttagc aactaaactc tctttcctac     3180

ctccatttaa tggatggaga aactgagtcc aaaagttcta ataatctgtg ttgagacatg     3240

tgactaggta ataagaactc agttttattg acttttcggt atatgctcta ggcaaaaagt     3300

actttgcaaa gtctaaagaa ctataagatg ctaactattt gatattaatg ataactctgt     3360

tgtctttgaa attatacttt ttctgtaggt gaggtatcct acagtatatt agtgcgtcct     3420

ctgtctaggc agtcaattag tagaccattg agcttgacct cagaatatag tctgaatagg     3480

acctaggaat tcaattcttt tttttttttt tctcaatggg ggctcaaaga gctctgggat     3540

agagctccta gactacagct gggggttgtg gggaggccag atggggtacg gggatggcaa     3600

atgccttcag tactgcctgc ctatttctaa aaaagaagtg atgagttcca tgtttgagcc     3660

taaaaggtgg cttcctctcc tagctgatga tgaacttaat gattccaaat gtgaggtctg     3720

aaagagcttt tctataggaa taagcatcct cagggttgtg ggtgaaagag tagagtttct     3780

acctgcttca tgtcaatggc aaaaaatcag aatctgtaat ataatctatt attctttggg     3840

tccttttcag catgcccaca tgacatgcca ttgtggggag gaagcaatga agaaatacag     3900

ccagattctg agtcactttg aaaaggtata tgcgactttg gcattgattg ggatgggtgt     3960

gttttaagaa ctgagatcat aggtaggtgg gatggttatt cactgttaga catcctgtag     4020

ccttcaggtt catagccctc tgaaatcatg aggaccagcc cttgctttaa cccaggggac     4080

acccatccag gctctagagg agtaccctct ctgggtgatg ctctggaaat ggaaagggaa     4140

tggccatgat tccatcaagt cactacagtg acatctggat cttttagctg cacaaaccag     4200

aggcaatagt tttacaatgt tcacacactt ctatgtacct ttgaaaacac tcacaatttc     4260

acacacacac ccatgccatt caatttctca ccttcacacc ttctcatgtc tgccaggaag     4320

gcctggattt cactcctcac tgactaaatc ctactcatcc tttaaagact cagcctgggc     4380

atcactttca ggaaggtgct ggctccttct ctcagagtta gatgcctccc acatcatctt     4440

gtaggaattt catcccttta ttcaccacac tacattttag ttgcctgttt ttgccagtct     4500

cctcactcaa ctgtggatag ggattgtgcc attcaccttt tcatccctaa ccatcagcta     4560

ggtgattggc acaatcaata tctgttcaac tgatgtgtgc accgtaggca acccctacac     4620

acacacacag gcacgtgcac acacacacac acacacgttt cttaaagaaa atagcttgat     4680

tattttgatc tctgtgattc aagagtctta agtagcagtt ttacttctgc tacccccttg     4740

cacctcagtt tctgtacata agaccagggt gatgaactca atgatttccc ttccttgtgt     4800

gatatcttga gattctataa cttctttaag tgcttcatct tgaaaagaat gctctgctta     4860

caattgtcag cagacctatc cataaaagag ataggtcctg gagcaaatgc tgtctcatga     4920

attgctaacc acatgggtgt gtgtctcttt cagctggaac ctcaggcagc agttgtgaag     4980

gctttggggg aactagacat tcttctgcaa tggatggagg agacagaata ggaggaaagt     5040

gatgctgctg ctaagaatat tcgaggtcaa gagctccagt cttcaatacc tgcagaggag     5100

gcatgacccc aaaccaccat ctctttactg tactagtctt gtgctggtca cagtgtatct     5160

tatttatgca ttacttgctt ccttgcatga ttgtctttat gcatccccaa tcttaattga     5220

gaccatactt gtataagatt tttgtaatat ctttctgcta ttggatatat ttattagtta     5280

atatatttat ttattttttg ctatttaatg tatttatttt tttacttgga catgaaactt     5340

taaaaaaatt cacagattat atttataacc tgactagagc aggtgatgta tttttataca     5400

gtaaaaaaaa aaaaccttgt aaattctaga agagtggcta ggggggttat tcatttgtat     5460

tcaactaagg acatatttac tcatgctgat gctctgtgag atatttgaaa ttgaaccaat     5520

gactacttag gatgggttgt ggaataagtt ttgatgtgga attgcacatc taccttacaa     5580

ttactgacca tccccagtag actccccagt cccataattg tgtatcttcc agccaggaat     5640

cctacacggc cagcatgtat ttctacaaat aaagttttct ttgcataaca tctgcttgga     5700

gtttgcaaat gtttcaagag cagagaccat gttgaggata agtttgaatc tcatttcacc     5760

ccaggtcctc ttgctccttt gaggaagaag atgtaggaac ctcgatcttc tctctcctgc     5820

agatttcatc ctcagctcta tctcctaatt catactgctc tgaccccacg actgccctcc     5880

tctcaaaagg actgtgacag agtgaggggc ttcagccatc tctgctttcg cctcattggc     5940

ttggagcact gccctttcta tacctctgtt ttctttctca ccccataccc ttgcaagaca     6000

aattacaatg ggcatgaggc gctattataa aggttaaaaa cacacaggtg caaagtgtag     6060

gtctagagtc ttgcccagac aggtgtatga gccccctttt gaggcccttc cattttggat     6120

tctgtccagc ctcagagttt aggttgttac cagatcaagt ccttatcttt gtgtccaact     6180

attaagtcag tgttttcttt ccaggccccc ttcaggttga gtgtccctgg acactgagga     6240

gccagagttc tggcctgggc tggttccttc cttcttcccc cacctcactc tgaagcgcac     6300

ccccaattta gttgcttagt tttctcagtc tcagaaacaa cagtctcagg ctgattccct     6360

gggtcctaaa gataactctc cttactgctt taatttctac tccctgttct tagcctgggc     6420

cctgatatag tttcaatgac tttaactttt gataactctc attatacaag taacagctgc     6480

ccaacagaaa agaaattttg gaagaaaaca gaaatataaa gaagaaaatt aaaatcaccc     6540

ataatctcac caccctcaga caaccacttt taaacattta tgcttatttt ttccagatat     6600

tttttgatgg gttcaaatca tgactcagct ctca                                 6634


<210>  6
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Ala Ser Ser Leu Ala Phe Ser Leu Leu Ser Ala Ala Phe Tyr 
1               5                   10                  15      


Leu Leu Trp Thr Pro Ser Thr Gly Leu Lys Thr Leu Asn Leu Gly Ser 
            20                  25                  30          


Cys Val Ile Ala Thr Asn Leu Gln Glu Ile Arg Asn Gly Phe Ser Glu 
        35                  40                  45              


Ile Arg Gly Ser Val Gln Ala Lys Asp Gly Asn Ile Asp Ile Arg Ile 
    50                  55                  60                  


Leu Arg Arg Thr Glu Ser Leu Gln Asp Thr Lys Pro Ala Asn Arg Cys 
65                  70                  75                  80  


Cys Leu Leu Arg His Leu Leu Arg Leu Tyr Leu Asp Arg Val Phe Lys 
                85                  90                  95      


Asn Tyr Gln Thr Pro Asp His Tyr Thr Leu Arg Lys Ile Ser Ser Leu 
            100                 105                 110         


Ala Asn Ser Phe Leu Thr Ile Lys Lys Asp Leu Arg Leu Cys His Ala 
        115                 120                 125             


His Met Thr Cys His Cys Gly Glu Glu Ala Met Lys Lys Tyr Ser Gln 
    130                 135                 140                 


Ile Leu Ser His Phe Glu Lys Leu Glu Pro Gln Ala Ala Val Val Lys 
145                 150                 155                 160 


Ala Leu Gly Glu Leu Asp Ile Leu Leu Gln Trp Met Glu Glu Thr Glu 
                165                 170                 175     


<210>  7
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Leu Leu Leu Ala Leu Ser Leu Leu Val Leu Trp Thr Ser Pro 
1               5                   10                  15      


Ala Pro Thr Leu Ser Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser 
            20                  25                  30          


Val Thr Gln Lys Pro Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr 
        35                  40                  45              


Leu Leu Ile Lys Asp Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr 
    50                  55                  60                  


Leu Arg Gly Arg Gln Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu 
65                  70                  75                  80  


Arg Ile Ile Gln Arg Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg 
                85                  90                  95      


Ser Ser 
        


