                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
       UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
       UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF 
       HIGHER EDUCATION
 
<120>  GRIFFITHSIN MUTANTS

<130>  722766

<150>  US 62/114,217
<151>  2015-02-10

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  wherein X can be M or V

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  X can be E or Q

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  X can be M, A, K, V, F, L, I, Q, R, or G

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  X can be S or R

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  X can be A or S

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  X can be I or F

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  X can be E or Q

<400>  1

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Xaa Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Xaa Thr Asn Xaa Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Xaa Xaa Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Xaa Tyr Tyr Xaa Gln Tyr 
        115                 120     


<210>  2
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Met Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Glu Thr Asn Met Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Ser Ala Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Ile Tyr Tyr Glu Gln Tyr 
        115                 120     


<210>  3
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Val Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Gln Thr Asn Lys Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Ser Ala Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Ile Tyr Tyr Glu Gln Tyr 
        115                 120     


<210>  4
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
agcctgaccc atcgcaagtt cggtggtagt ggtggaagtc cgttctctgg tctgagcagc       60

attgcagttc gtagtggcag ctatctggat gcgatcatca ttgatggtgt acatcacggt      120

ggctctggtg gtaacctgag tccgaccttc acctttggat ccggtgagta catcagcaac      180

gtgaccattc gtagtggaga ctacattgac aacatcagct ttcaaaccaa caagggtcgt      240

cgctttggtc cgtatggtgg atctggtggc agtgcaaaca ccctgagcaa cgtgaaagtc      300

atccagatca acggtagtgc aggtgactat ctggatagcc tggacatcta ctatgaacag      360

tactaa                                                                 366


<210>  5
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Val Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Gln Thr Asn Lys Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Arg Ala Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Ile Tyr Tyr Glu Gln Tyr 
        115                 120     


<210>  6
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
agcctgaccc atcgcaagtt cggtggtagt ggtggaagtc cgttctctgg tctgagcagc       60

attgcagttc gtagtggcag ctatctggat gcgatcatca ttgatggtgt acatcacggt      120

ggctctggtg gtaacctgag tccgaccttc acctttggat ccggtgagta catcagcaac      180

gtgaccattc gtagtggaga ctacattgac aacatcagct ttcaaaccaa caagggtcgt      240

cgctttggtc cgtatggtgg atctggtggc agtgcaaaca ccctgagcaa cgtgaaagtc      300

atccagatca acggtcgtgc aggtgactat ctggatagcc tggacatcta ctatgaacag      360

tactaa                                                                 366


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Val Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Gln Thr Asn Lys Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Ser Ala Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Phe Tyr Tyr Gln Gln Tyr 
        115                 120     


<210>  8
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
agcctgaccc atcgcaagtt cggtggtagt ggtggaagtc cgttctctgg tctgagcagc       60

attgcagttc gtagtggcag ctatctggat gcgatcatca ttgatggtgt acatcacggt      120

ggctctggtg gtaacctgag tccgaccttc acctttggat ccggtgagta catcagcaac      180

gtgaccattc gtagtggaga ctacattgac aacatcagct ttcaaaccaa caagggtcgt      240

cgctttggtc cgtatggtgg atctggtggc agtgcaaaca ccctgagcaa cgtgaaagtc      300

atccagatca acggtagtgc aggtgactat ctggatagcc tggacttcta ctatcagcag      360

tactaa                                                                 366


<210>  9
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Met Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Gln Thr Asn Lys Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Arg Ala Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Ile Tyr Tyr Glu Gln Tyr 
        115                 120     


<210>  10
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
agcctgaccc atcgcaagtt cggtggtagt ggtggaagtc cgttctctgg tctgagcagc       60

attgcagttc gtagtggcag ctatctggat gcgatcatca ttgatggtgt acatcacggt      120

ggctctggtg gtaacctgag tccgaccttc acctttggat ccggtgagta catcagcaac      180

atgaccattc gtagtggaga ctacattgac aacatcagct ttcaaaccaa caagggtcgt      240

cgctttggtc cgtatggtgg atctggtggc agtgcaaaca ccctgagcaa cgtgaaagtc      300

atccagatca acggtcgtgc aggtgactat ctggatagcc tggacatcta ctatgaacag      360

tactaa                                                                 366


<210>  11
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  wherein X is M

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  wherein  X is Q

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  wherein  X is K, V, or A

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  wherein  X is S

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  wherein  X is A

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  wherein X is I

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  wherein X is E

<400>  11

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Xaa Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Xaa Thr Asn Xaa Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Xaa Xaa Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Xaa Tyr Tyr Xaa Gln Tyr 
        115                 120     


<210>  12
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  wherein X is M

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  wherein X is Q

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  wherein X is K

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  wherein X is S

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  wherein X is  A

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  wherein X is I

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  wherein X is Q

<400>  12

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Xaa Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Xaa Thr Asn Xaa Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Xaa Xaa Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Xaa Tyr Tyr Xaa Gln Tyr 
        115                 120     


<210>  13
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  wherein X is V

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  wherein X is Q

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  wherein X is K

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  wherein X is S

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  wherein X is A

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  wherein X is I

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  wherein X is Q

<400>  13

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Xaa Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Xaa Thr Asn Xaa Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Xaa Xaa Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Xaa Tyr Tyr Xaa Gln Tyr 
        115                 120     


<210>  14
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  wherein X is M

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  wherein X is Q

<220>
<221>  MISC_FEATURE
<222>  (78)..(78)
<223>  wherein X is K

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  wherein X is S

<220>
<221>  MISC_FEATURE
<222>  (107)..(107)
<223>  wherein X is A

<220>
<221>  MISC_FEATURE
<222>  (116)..(116)
<223>  wherein X is F

<220>
<221>  MISC_FEATURE
<222>  (119)..(119)
<223>  wherein X is Q

<400>  14

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Xaa Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Xaa Thr Asn Xaa Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Xaa Xaa Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Xaa Tyr Tyr Xaa Gln Tyr 
        115                 120     


<210>  15
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Met Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Glu Thr Asn Ala Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Ser Ala Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Ile Tyr Tyr Glu Gln Tyr 
        115                 120     


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Met Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Glu Thr Asn Lys Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Ser Ala Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Ile Tyr Tyr Glu Gln Tyr 
        115                 120     


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Met Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Glu Thr Asn Leu Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Ser Ala Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Ile Tyr Tyr Glu Gln Tyr 
        115                 120     


<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Ser Leu Thr His Arg Lys Phe Gly Gly Ser Gly Gly Ser Pro Phe Ser 
1               5                   10                  15      


Gly Leu Ser Ser Ile Ala Val Arg Ser Gly Ser Tyr Leu Asp Ala Ile 
            20                  25                  30          


Ile Ile Asp Gly Val His His Gly Gly Ser Gly Gly Asn Leu Ser Pro 
        35                  40                  45              


Thr Phe Thr Phe Gly Ser Gly Glu Tyr Ile Ser Asn Met Thr Ile Arg 
    50                  55                  60                  


Ser Gly Asp Tyr Ile Asp Asn Ile Ser Phe Glu Thr Asn Gln Gly Arg 
65                  70                  75                  80  


Arg Phe Gly Pro Tyr Gly Gly Ser Gly Gly Ser Ala Asn Thr Leu Ser 
                85                  90                  95      


Asn Val Lys Val Ile Gln Ile Asn Gly Ser Ala Gly Asp Tyr Leu Asp 
            100                 105                 110         


Ser Leu Asp Ile Tyr Tyr Glu Gln Tyr 
        115                 120     


