                         SEQUENCE LISTING

<110>  Medical Research & Development Fund for Health Services 
       Bnai Zion Medical Center
 
<120>  SEMAPHORIN 3A FOR TREATMENT AND ASSESSMENT OF SEVERITY OF 
       INFLAMMATORY BOWEL DISEASE

<130>  BZM/003 PCT

<150>  62/114086
<151>  2015-02-10

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  771
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      


Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          


Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              


Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  


Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  


Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      


Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys 
            100                 105                 110         


Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             


Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 


Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 


His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     


Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         


Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             


His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 


Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 


Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     


Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         


Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 


Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 


Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     


Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         


Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             


Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 


Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 


Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met 
                405                 410                 415     


Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         


Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             


Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 


Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 


Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     


Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         


Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             


Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg 
    530                 535                 540                 


Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 


Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His Asp Asn His His 
                565                 570                 575     


Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser 
            580                 585                 590         


Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp 
        595                 600                 605             


Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp 
    610                 615                 620                 


Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln 
625                 630                 635                 640 


Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe 
                645                 650                 655     


Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His 
            660                 665                 670         


Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr 
        675                 680                 685             


Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg 
    690                 695                 700                 


Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu 
705                 710                 715                 720 


Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg 
                725                 730                 735     


Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu 
            740                 745                 750         


Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro 
        755                 760                 765             


Arg Ser Val 
    770     


<210>  2
<211>  2316
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA

<400>  2
atgggctggt taactaggat tgtctgtctt ttctggggag tattacttac agcaagagca       60

aactatcaga atgggaagaa caatgtgcca aggctgaaat tatcctacaa agaaatgttg      120

gaatccaaca atgtgatcac tttcaatggc ttggccaaca gctccagtta tcataccttc      180

cttttggatg aggaacggag taggctgtat gttggagcaa aggatcacat attttcattc      240

gacctggtta atatcaagga ttttcaaaag attgtgtggc cagtatctta caccagaaga      300

gatgaatgca agtgggctgg aaaagacatc ctgaaagaat gtgctaattt catcaaggta      360

cttaaggcat ataatcagac tcacttgtac gcctgtggaa cgggggcttt tcatccaatt      420

tgcacctaca ttgaaattgg acatcatcct gaggacaata tttttaagct ggagaactca      480

cattttgaaa acggccgtgg gaagagtcca tatgacccta agctgctgac agcatccctt      540

ttaatagatg gagaattata ctctggaact gcagctgatt ttatggggcg agactttgct      600

atcttccgaa ctcttgggca ccaccaccca atcaggacag agcagcatga ttccaggtgg      660

ctcaatgatc caaagttcat tagtgcccac ctcatctcag agagtgacaa tcctgaagat      720

gacaaagtat actttttctt ccgtgaaaat gcaatagatg gagaacactc tggaaaagct      780

actcacgcta gaataggtca gatatgcaag aatgactttg gagggcacag aagtctggtg      840

aataaatgga caacattcct caaagctcgt ctgatttgct cagtgccagg tccaaatggc      900

attgacactc attttgatga actgcaggat gtattcctaa tgaactttaa agatcctaaa      960

aatccagttg tatatggagt gtttacgact tccagtaaca ttttcaaggg atcagccgtg     1020

tgtatgtata gcatgagtga tgtgagaagg gtgttccttg gtccatatgc ccacagggat     1080

ggacccaact atcaatgggt gccttatcaa ggaagagtcc cctatccacg gccaggaact     1140

tgtcccagca aaacatttgg tggttttgac tctacaaagg accttcctga tgatgttata     1200

acctttgcaa gaagtcatcc agccatgtac aatccagtgt ttcctatgaa caatcgccca     1260

atagtgatca aaacggatgt aaattatcaa tttacacaaa ttgtcgtaga ccgagtggat     1320

gcagaagatg gacagtatga tgttatgttt atcggaacag atgttgggac cgttcttaaa     1380

gtagtttcaa ttcctaagga gacttggtat gatttagaag aggttctgct ggaagaaatg     1440

acagtttttc gggaaccgac tgctatttca gcaatggagc tttccactaa gcagcaacaa     1500

ctatatattg gttcaacggc tggggttgcc cagctccctt tacaccggtg tgatatttac     1560

gggaaagcgt gtgctgagtg ttgcctcgcc cgagaccctt actgtgcttg ggatggttct     1620

gcatgttctc gctattttcc cactgcaaag agacgcacaa gacgacaaga tataagaaat     1680

ggagacccac tgactcactg ttcagactta caccatgata atcaccatgg ccacagccct     1740

gaagagagaa tcatctatgg tgtagagaat agtagcacat ttttggaatg cagtccgaag     1800

tcgcagagag cgctggtcta ttggcaattc cagaggcgaa atgaagagcg aaaagaagag     1860

atcagagtgg atgatcatat catcaggaca gatcaaggcc ttctgctacg tagtctacaa     1920

cagaaggatt caggcaatta cctctgccat gcggtggaac atgggttcat acaaactctt     1980

cttaaggtaa ccctggaagt cattgacaca gagcatttgg aagaacttct tcataaagat     2040

gatgatggag atggctctaa gaccaaagaa atgtccaata gcatgacacc tagccagaag     2100

gtctggtaca gagacttcat gcagctcatc aaccacccca atctcaacac aatggatgag     2160

ttctgtgaac aagtttggaa aagggaccga aaacaacgtc ggcaaaggcc aggacatacc     2220

ccagggaaca gtaacaaatg gaagcactta caagaaaata agaaaggtag aaacaggagg     2280

acccacgaat ttgagagggc acccaggagt gtctga                               2316


