                         SEQUENCE LISTING

<110>  Nuclera Nucleics Ltd
 
<120>  NOVEL USE

<130>  NUC-C-P1848PCT

<150>  1502152.0
<151>  2015-02-10

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  517
<212>  PRT
<213>  Sarcophilus harrisii

<400>  1

Met His Arg Ile Arg Thr Thr Asp Ser Asp His Gly Lys Lys Arg Gln 
1               5                   10                  15      


Lys Lys Met Asp Ala Ile Ser Ser Lys Leu Tyr Glu Ile Lys Phe His 
            20                  25                  30          


Glu Phe Val Leu Phe Ile Leu Glu Lys Lys Met Gly Ala Thr Arg Arg 
        35                  40                  45              


Thr Phe Leu Met Asp Leu Ala Arg Lys Lys Gly Phe Arg Val Glu Ser 
    50                  55                  60                  


Glu Leu Ser Asn Ser Val Thr His Ile Val Ala Glu Asn Asn Ser Gly 
65                  70                  75                  80  


Ser Asp Val Leu Ala Trp Leu Glu Ala His Lys Leu Glu Thr Thr Ala 
                85                  90                  95      


His Phe Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Cys Met Lys Val 
            100                 105                 110         


Gly Lys Pro Val Asp Thr Lys Gly Lys Tyr Gln Leu Val Glu Ser Ser 
        115                 120                 125             


Ile Ala Ser Ala Asn Pro Asp Pro Asn Glu Gly Met Leu Lys Ile Gln 
    130                 135                 140                 


Ser Pro Ala Met Asn Ala Ile Ser Pro Tyr Ala Cys Gln Arg Arg Thr 
145                 150                 155                 160 


Thr Leu Asn Asn His Asn Gln Arg Phe Thr Asp Ala Phe Glu Ile Leu 
                165                 170                 175     


Ala Lys Asn Tyr Glu Phe Arg Glu Asn His Gly His Cys Leu Thr Phe 
            180                 185                 190         


Leu Arg Ala Thr Ser Val Leu Lys Cys Leu Pro Phe Ala Ile Val Ser 
        195                 200                 205             


Met Lys Asp Ala Glu Gly Leu Pro Trp Ile Gly Asp Glu Val Lys Gly 
    210                 215                 220                 


Ile Met Glu Glu Ile Ile Glu Asp Gly Gln Ser Leu Glu Val Gln Ala 
225                 230                 235                 240 


Val Leu Asn Asp Glu Arg Tyr Gln Ala Phe Lys Leu Phe Thr Ser Val 
                245                 250                 255     


Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Tyr Arg Met Gly Phe 
            260                 265                 270         


Arg Thr Leu Ser Lys Ile Gln Ser Asp Lys Ser Leu Lys Phe Thr Lys 
        275                 280                 285             


Met Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Ile Ser Cys Val 
    290                 295                 300                 


Ser Lys Ala Glu Ala Asp Ala Val Ser Leu Ile Val Lys Glu Ala Val 
305                 310                 315                 320 


Trp Thr Phe Leu Pro Asp Ala Leu Ile Thr Ile Thr Gly Gly Phe Arg 
                325                 330                 335     


Arg Gly Lys Glu Phe Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro 
            340                 345                 350         


Gly Gly Glu Lys Glu Gln Val Asp Gln Leu Leu Gln Lys Val Thr Asn 
        355                 360                 365             


Leu Trp Glu Lys Gln Gly Leu Leu Leu Tyr Tyr Asp Leu Met Glu Ser 
    370                 375                 380                 


Thr Phe Glu Asp Leu Lys Leu Pro Ser Arg Lys Val Asp Ala Leu Asp 
385                 390                 395                 400 


His Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu Tyr Cys Gln Arg Gly 
                405                 410                 415     


Asp Arg Ser Lys Trp Glu Gly Pro Glu Gly Ser Asn Gly Leu Gln Thr 
            420                 425                 430         


Lys Asn Trp Lys Ala Ile Arg Val Asp Leu Val Val Cys Pro Tyr Asp 
        435                 440                 445             


Arg Tyr Ala Tyr Ala Leu Leu Gly Trp Ser Gly Ser Arg Gln Phe Glu 
    450                 455                 460                 


Arg Asp Leu Arg Arg Tyr Ala Thr His Glu Lys Lys Met Met Leu Asp 
465                 470                 475                 480 


Asn His Ala Leu Tyr Asp Lys Thr Lys Arg Thr Phe Leu Lys Ala Glu 
                485                 490                 495     


Ser Glu Glu Glu Ile Phe Ser His Leu Gly Leu Glu Tyr Ile Glu Pro 
            500                 505                 510         


Trp Glu Arg Asn Ala 
        515         


<210>  2
<211>  494
<212>  PRT
<213>  Lepisosteus oculatus

<400>  2

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asp Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Trp Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Tyr Leu Lys Lys Lys Thr Thr Asn Asn Tyr Leu Ala Leu 
465                 470                 475                 480 


Asn Asp Val Cys Ser Asp Leu Ser Glu Trp His Tyr Lys Gly 
                485                 490                 


<210>  3
<211>  510
<212>  PRT
<213>  Chinchilla lanigera

<400>  3

Met Asp Pro Leu Gln Ala Ala His Ser Gly Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Thr Gly Thr Leu Met Val Ser Ser Pro His Asp Val Arg Phe 
            20                  25                  30          


Gly Asp Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg 
        35                  40                  45              


Arg Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Asn Asp Val Leu Glu Trp Leu Gln Val Gln Asn Ile Gln Ala Ser 
                85                  90                  95      


Ser Arg Leu Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Cys Met Gly 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Met Thr Gly Lys His Gln Leu Leu Val Arg 
        115                 120                 125             


Arg Asp Tyr Pro Ala Ser Pro Lys Pro Gly Pro Gln Lys Thr Pro Ser 
    130                 135                 140                 


Leu Ala Val Gln Lys Ile Ser Glu Tyr Ala Cys Gln Arg Arg Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Cys Asn Cys Ile Phe Thr Asn Ala Phe Glu Ile Leu Ala 
                165                 170                 175     


Glu Asn Cys Glu Phe Arg Glu Asn Glu Ser Ser Tyr Val Thr Tyr Met 
            180                 185                 190         


Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met 
        195                 200                 205             


Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Glu Lys Val Lys Cys Ile 
    210                 215                 220                 


Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Asn Ala Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg 
            260                 265                 270         


Ser Leu Asn Lys Ile Lys Ser Asp Lys Ser Leu Lys Phe Thr Arg Met 
        275                 280                 285             


Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr 
    290                 295                 300                 


Arg Ala Glu Ala Glu Ala Val Ser Met Leu Val Lys Glu Ala Val Trp 
305                 310                 315                 320 


Ala Phe Leu Pro Gly Ala Phe Ile Ser Met Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Glu Ile Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu 
            340                 345                 350         


Val Thr Glu Asp Glu Lys Gln Gln Leu Leu His Lys Val Ile Ser Leu 
        355                 360                 365             


Trp Glu Lys Lys Gly Leu Leu Leu Tyr Ser Asp Leu Val Glu Ser Thr 
    370                 375                 380                 


Phe Glu Lys Leu Lys Leu Pro Ser Arg Lys Val Asp Ala Leu Asp His 
385                 390                 395                 400 


Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu His His Gln Arg Val Asp 
                405                 410                 415     


Ser Asp Lys Ser Pro Gln Gln Gly Gly Lys Thr Trp Lys Ala Ile Arg 
            420                 425                 430         


Val Asp Leu Val Val Cys Pro Tyr Glu Arg Arg Ala Phe Ala Leu Leu 
        435                 440                 445             


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala 
    450                 455                 460                 


Thr His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys 
465                 470                 475                 480 


Thr Lys Arg Ile Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala 
                485                 490                 495     


His Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505                 510 


<210>  4
<211>  511
<212>  PRT
<213>  Otolemur garnettii

<400>  4

Met Asp Pro Leu His Met Ala His Ser Gly Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Thr Ala Ala Ser Met Val Ser Thr Pro Gln Asp Ile Lys Phe 
            20                  25                  30          


Arg Asp Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg 
        35                  40                  45              


Arg Thr Phe Leu Met Glu Leu Ala Arg Thr Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Phe Ser Asp Ser Val Thr His Ile Ile Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Asp Val Leu Glu Trp Ile Gln Val Gln Lys Ile Lys Ala Gly 
                85                  90                  95      


Ser Gln Met Glu Val Leu Asp Val Ser Trp Leu Ile Glu Cys Met Arg 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Met Thr Gly Lys His Gln Leu Val Val Arg 
        115                 120                 125             


Gly Asp Tyr Ser Pro Ser Pro Asn Pro Ala Pro Gln Lys Thr Pro Pro 
    130                 135                 140                 


Leu Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Cys Asn His Ile Phe Thr Asp Ala Phe Glu Ile Met Ala 
                165                 170                 175     


Glu Asn Tyr Glu Phe Arg Glu Asn Glu Gly Tyr Ser Ala Ala Phe Met 
            180                 185                 190         


Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met 
        195                 200                 205             


Lys Asp Thr Glu Gly Val Pro Cys Leu Gly Asp Asn Val Lys Cys Ile 
    210                 215                 220                 


Ile Glu Glu Ile Ile Glu Glu Gly Glu Ser Ser Glu Val Lys Ala Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg 
            260                 265                 270         


Thr Leu Ser Lys Ile Arg Ser Asp Lys Ser Leu Arg Phe Thr Arg Met 
        275                 280                 285             


Gln Gln Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr 
    290                 295                 300                 


Arg Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Arg 
305                 310                 315                 320 


Ala Phe Leu Pro Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Asn Ile Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly 
            340                 345                 350         


Ser Thr Glu Glu Glu Glu Gln Gln Leu Leu His Lys Ile Met Asp Leu 
        355                 360                 365             


Trp Glu Lys Lys Gly Leu Leu Leu Tyr Cys Asp Leu Val Glu Ser Thr 
    370                 375                 380                 


Phe Glu Lys Leu Lys Leu Pro Ser Arg Lys Val Asp Ala Leu Asp His 
385                 390                 395                 400 


Phe Gln Lys Cys Phe Leu Ile Phe Lys Leu His His Gln Arg Val Val 
                405                 410                 415     


Asp Ser Glu Gln Ser Asn Gln Gln Glu Gly Lys Thr Trp Lys Ala Ile 
            420                 425                 430         


Arg Val Asp Leu Val Met Cys Pro Tyr Glu Arg Arg Ala Tyr Ala Leu 
        435                 440                 445             


Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr 
    450                 455                 460                 


Ala Thr His Glu Arg Lys Met Ile Leu Asp Asn His Gly Leu Trp Asp 
465                 470                 475                 480 


Lys Thr Lys Arg Ile Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe 
                485                 490                 495     


Ala His Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505                 510     


<210>  5
<211>  510
<212>  PRT
<213>  Sus scrofa

<400>  5

Met Asp Pro Pro Gln Thr Val Pro Ser Ser Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Val Gly Ala Ser Met Ala Ser Pro Ala His Asn Ile Lys Phe 
            20                  25                  30          


Arg Glu Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg 
        35                  40                  45              


Arg Thr Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Glu Val Leu Glu Trp Leu Gln Ala Gln Lys Ile Arg Ala Ser 
                85                  90                  95      


Ser Gln Leu Thr Leu Leu Asp Val Ser Trp Leu Ile Glu Ser Met Gly 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Met Thr Gly Lys His Gln Leu Val Val Arg 
        115                 120                 125             


Thr Asp Cys Ser Ala Ser Pro Ser Pro Gly Ser Gln Asn Thr Leu Pro 
    130                 135                 140                 


Pro Ala Val Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Cys Asn His Ile Phe Thr Asp Ala Phe Glu Val Leu Ala 
                165                 170                 175     


Glu Asn Tyr Glu Phe Arg Glu Asn Glu Thr Phe Cys Leu Ala Phe Met 
            180                 185                 190         


Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met 
        195                 200                 205             


Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Asp Lys Val Lys Cys Val 
    210                 215                 220                 


Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Leu Lys Thr Ser Glu Arg Trp Phe Arg Met Gly Phe Arg 
            260                 265                 270         


Ser Leu Ser Lys Ile Arg Ser Asp Lys Thr Leu Lys Phe Thr Arg Met 
        275                 280                 285             


Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr 
    290                 295                 300                 


Arg Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Gln 
305                 310                 315                 320 


Ala Phe Leu Pro Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Lys Met Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly 
            340                 345                 350         


Ser Thr Asp Asp Glu Glu Gln Gln Leu Leu Pro Lys Val Val Asn Leu 
        355                 360                 365             


Trp Glu Arg Glu Gly Leu Leu Leu Tyr Cys Asp Leu Val Glu Ser Thr 
    370                 375                 380                 


Leu Glu Lys Ser Lys Leu Pro Ser Arg Asn Val Asp Ala Leu Asp His 
385                 390                 395                 400 


Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu His His Gln Arg Val Asp 
                405                 410                 415     


Ser Gly Met Ser Ser Gln Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg 
            420                 425                 430         


Val Asp Leu Val Met Cys Pro Tyr Glu Leu Arg Ala Phe Ala Leu Leu 
        435                 440                 445             


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala 
    450                 455                 460                 


Thr His Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys 
465                 470                 475                 480 


Thr Lys Arg Ile Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala 
                485                 490                 495     


His Leu Gly Leu Asp Tyr Leu Glu Pro Trp Glu Arg Asn Ala 
            500                 505                 510 


<210>  6
<211>  509
<212>  PRT
<213>  Bos taurus

<400>  6

Met Asp Pro Leu Cys Thr Ala Ser Ser Gly Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Val Gly Ala Ser Met Ala Ser Pro Pro His Asp Ile Lys Phe 
            20                  25                  30          


Gln Asn Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg 
        35                  40                  45              


Arg Asn Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Glu Val Leu Glu Trp Leu Gln Val Gln Asn Ile Arg Ala Ser 
                85                  90                  95      


Ser Gln Leu Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Ser Met Gly 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Ile Thr Gly Lys His Gln Leu Val Val Arg 
        115                 120                 125             


Thr Asp Tyr Ser Ala Thr Pro Asn Pro Gly Phe Gln Lys Thr Pro Pro 
    130                 135                 140                 


Leu Ala Val Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Tyr Asn His Ile Phe Thr Asp Ala Phe Glu Ile Leu Ala 
                165                 170                 175     


Glu Asn Ser Glu Phe Lys Glu Asn Glu Val Ser Tyr Val Thr Phe Met 
            180                 185                 190         


Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met 
        195                 200                 205             


Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Asp Lys Val Lys Cys Ile 
    210                 215                 220                 


Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg 
            260                 265                 270         


Ser Leu Ser Lys Ile Met Ser Asp Lys Thr Leu Lys Phe Thr Lys Met 
        275                 280                 285             


Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr 
    290                 295                 300                 


Arg Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Trp 
305                 310                 315                 320 


Ala Phe Leu Pro Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Lys Ile Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly 
            340                 345                 350         


Ser Ala Glu Asp Glu Glu Gln Leu Leu Pro Lys Val Ile Asn Leu Trp 
        355                 360                 365             


Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe 
    370                 375                 380                 


Glu Lys Phe Lys Leu Pro Ser Arg Gln Val Asp Thr Leu Asp His Phe 
385                 390                 395                 400 


Gln Lys Cys Phe Leu Ile Leu Lys Leu His His Gln Arg Val Asp Ser 
                405                 410                 415     


Ser Lys Ser Asn Gln Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg Val 
            420                 425                 430         


Asp Leu Val Met Cys Pro Tyr Glu Asn Arg Ala Phe Ala Leu Leu Gly 
        435                 440                 445             


Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Ile Arg Arg Tyr Ala Thr 
    450                 455                 460                 


His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys Thr 
465                 470                 475                 480 


Lys Arg Val Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala His 
                485                 490                 495     


Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505                 


<210>  7
<211>  12
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Oligonucleotide

<400>  7
cgttaacata tt                                                           12


<210>  8
<211>  494
<212>  PRT
<213>  Synthetic Sequence

<400>  8

Met Leu His Ile Pro Ile Phe Pro Pro Ile Lys Lys Arg Gln Lys Leu 
1               5                   10                  15      


Pro Glu Ser Arg Asn Ser Cys Lys Tyr Glu Val Lys Phe Ser Glu Val 
            20                  25                  30          


Ala Ile Phe Leu Val Glu Arg Lys Met Gly Ser Ser Arg Arg Lys Phe 
        35                  40                  45              


Leu Thr Asn Leu Ala Arg Ser Lys Gly Phe Arg Ile Glu Asp Val Leu 
    50                  55                  60                  


Ser Asp Ala Val Thr His Val Val Ala Glu Asn Asn Ser Ala Asp Glu 
65                  70                  75                  80  


Leu Leu Gln Trp Leu Gln Asn Ser Ser Leu Gly Asp Leu Ser Lys Ile 
                85                  90                  95      


Glu Val Leu Asp Ile Ser Trp Phe Thr Glu Cys Met Gly Ala Gly Lys 
            100                 105                 110         


Pro Val Gln Val Glu Ala Arg His Cys Leu Val Lys Ser Cys Pro Val 
        115                 120                 125             


Ile Asp Gln Tyr Leu Glu Pro Ser Thr Val Glu Thr Val Ser Gln Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Met Glu Asn His Asn Gln Ile Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Ala Ile Leu Ala Glu Asn Ala Glu Phe Asn Glu Ser Glu 
                165                 170                 175     


Gly Pro Cys Leu Ala Phe Met Arg Ala Ala Ser Leu Leu Lys Ser Leu 
            180                 185                 190         


Pro His Ala Ile Ser Ser Ser Lys Asp Leu Glu Gly Leu Pro Cys Leu 
        195                 200                 205             


Gly Asp Gln Thr Lys Ala Val Ile Glu Asp Ile Leu Glu Tyr Gly Gln 
    210                 215                 220                 


Cys Ser Lys Val Gln Asp Val Leu Cys Asp Asp Arg Tyr Gln Thr Ile 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Arg Thr Ala Glu Lys 
                245                 250                 255     


Trp Tyr Arg Lys Gly Phe His Ser Leu Glu Glu Val Gln Ala Asp Asn 
            260                 265                 270         


Ala Ile His Phe Thr Lys Met Gln Lys Ala Gly Phe Leu Tyr Tyr Asp 
        275                 280                 285             


Asp Ile Ser Ala Ala Val Cys Lys Ala Glu Ala Gln Ala Ile Gly Gln 
    290                 295                 300                 


Ile Val Glu Glu Thr Val Arg Leu Ile Ala Pro Asp Ala Ile Val Thr 
305                 310                 315                 320 


Leu Thr Gly Gly Phe Arg Arg Gly Lys Glu Cys Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Thr Pro Glu Met Gly Lys Glu Val Trp Leu Leu Asn 
            340                 345                 350         


Arg Leu Ile Asn Arg Leu Gln Asn Gln Gly Ile Leu Leu Tyr Tyr Asp 
        355                 360                 365             


Ile Val Glu Ser Thr Phe Asp Lys Thr Arg Leu Pro Cys Arg Lys Phe 
    370                 375                 380                 


Glu Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Ile Lys Leu Lys 
385                 390                 395                 400 


Lys Glu Leu Ala Ala Gly Arg Val Gln Lys Asp Trp Lys Ala Ile Arg 
                405                 410                 415     


Val Asp Phe Val Ala Pro Pro Val Asp Asn Phe Ala Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Phe Ala 
        435                 440                 445             


Arg His Glu Arg Lys Met Leu Leu Asp Asn His Ala Leu Tyr Asp Lys 
    450                 455                 460                 


Thr Lys Lys Ile Phe Leu Pro Ala Lys Thr Glu Glu Asp Ile Phe Ala 
465                 470                 475                 480 


His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Gln Arg Asn Ala 
                485                 490                 


