                         SEQUENCE LISTING

<110>  UCL BUSINESS PLC
 
<120>  Treatment

<130>  N403455WO

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  1
tattgtgcaa ataagtgctc actccaaatt agtggtatat ttattgaagt ttaatattgt       60

gtttgtgata cagaagtatt tgctttaatt ctaaataaaa attttatgct tttattgctg      120

gtttaagaag atttggatta tccttgtact ttgaggagaa gtttcttatt tgaaatattt      180

tggaaacagg tcttttaatg tggaaagata gatattaatc tcctcttcta ttactctcca      240

agatccaaca aaagtgatta taccccccaa aatatgatgg tagtatctta tactaccatc      300

attttatagg catagggctc ttagctgcaa ataatggaac taactctaat aaagcagaac      360

gcaaatattg taaatattag agagctaaca atctctggga tggctaaagg atggagcttg      420

gaggctaccc agccagtaac aatattccgg gctccactgt tgaatggaga cactacaact      480

gccttggatg ggcagagata ttatggatgc taagccccag gtgctaccat taggacttct      540

accactgtcc ctaacgggtg gagcccatca catgcctatg ccctcactgt aaggaaatga      600

agctactgtt gtatatcttg ggaagcactt ggattaattg ttatacagtt ttgttgaaga      660

agacccctag ggtaagtagc cataactgca cactaaattt aaaattgtta atgagtttct      720

caaaaaaaat gttaaggttg ttagctggta tagtatatat cttgcctgtt ttccaaggac      780

ttctttgggc agtaccttgt ctgtgctggc aagcaactga gacttaatga aagagtattg      840

gagatatgaa tgaattgatg ctgtatactc tcagagtgcc aaacatatac caatggacaa      900

gaaggtgagg cagagagcag acaggcatta gtgacaagca aagatatgca gaatttcatt      960

ctcagcaaat caaaagtcct caacctggtt ggaagaatat tggcactgaa tggtatcaat     1020

aaggttgcta gagagggtta gaggtgcaca atgtgcttcc ataacatttt atacttctcc     1080

aatcttagca ctaatcaaac atggttgaat actttgttta ctataactct tacagagtta     1140

taagatctgt gaagacaggg acagggacaa tacccatctc tgtctggttc ataggtggta     1200

tgtaatagat atttttaaaa ataagtgagt taatgaatga gggtgagaat gaaggcacag     1260

aggtattagg gggaggtggg ccccagagaa tggtgccaag gtccagtggg gtgactggga     1320

tcagctcagg cctgacgctg gccactccca cctagctcct ttctttctaa tctgttctca     1380

ttctccttgg gaaggattga ggtctctgga aaacagccaa acaactgtta tgggaacagc     1440

aagcccaaat aaagccaagc atcaggggga tctgagagct gaaagcaact tctgttcccc     1500

ctccctcagc tgaaggggtg gggaagggct cccaaagcca taactccttt taagggattt     1560

agaaggcata aaaaggcccc tggctgagaa cttccttctt cattctgcag ttgg           1614


<210>  2
<211>  761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised human RPE65 promoter fragment

<400>  2
agatcttcga aatactctca gagtgccaaa catataccaa tggacaagaa ggtgaggcag       60

agagcagaca ggcattagtg acaagcaaag atatgcagaa tttcattctc agcaaatcaa      120

aagtcctcaa cctggttgga agaatattgg cactgaatgg tatcaataag gttgctagag      180

agggttagag gtgcacaatg tgcttccata acattttata cttctccaat cttagcacta      240

atcaaacatg gttgaatact ttgtttacta taactcttac agagttataa gatctgtgaa      300

gacagggaca gggacaatac ccatctctgt ctggttcata ggtggtatgt aatagatatt      360

tttaaaaata agtgagttaa tgaatgaggg tgagaatgaa ggcacagagg tattaggggg      420

aggtgggccc cagagaatgg tgccaaggtc cagtggggtg actgggatca gctcaggcct      480

gacgctggcc actcccacct agctcctttc tttctaatct gttctcattc tccttgggaa      540

ggattgaggt ctctggaaaa cagccaaaca actgttatgg gaacagcaag cccaaataaa      600

gccaagcatc agggggatct gagagctgaa agcaacttct gttccccctc cctcagctga      660

aggggtgggg aagggctccc aaagccataa ctccttttaa gggatttaga aggcataaaa      720

aggcccctgg ctgagaactt ccttcttcat tctgcagttg g                          761


<210>  3
<211>  1602
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtctatcc aggttgagca tcctgctggt ggttacaaga aactgtttga aactgtggag       60

gaactgtcct cgccgctcac agctcatgta acaggcagga tccccctctg gctcaccggc      120

agtctccttc gatgtgggcc aggactcttt gaagttggat ctgagccatt ttaccacctg      180

tttgatgggc aagccctcct gcacaagttt gactttaaag aaggacatgt cacataccac      240

agaaggttca tccgcactga tgcttacgta cgggcaatga ctgagaaaag gatcgtcata      300

acagaatttg gcacctgtgc tttcccagat ccctgcaaga atatattttc caggtttttt      360

tcttactttc gaggagtaga ggttactgac aatgcccttg ttaatgtcta cccagtgggg      420

gaagattact acgcttgcac agagaccaac tttattacaa agattaatcc agagaccttg      480

gagacaatta agcaggttga tctttgcaac tatgtctctg tcaatggggc cactgctcac      540

ccccacattg aaaatgatgg aaccgtttac aatattggta attgctttgg aaaaaatttt      600

tcaattgcct acaacattgt aaagatccca ccactgcaag cagacaagga agatccaata      660

agcaagtcag agatcgttgt acaattcccc tgcagtgacc gattcaagcc atcttacgtt      720

catagttttg gtctgactcc caactatatc gtttttgtgg agacaccagt caaaattaac      780

ctgttcaagt tcctttcttc atggagtctt tggggagcca actacatgga ttgttttgag      840

tccaatgaaa ccatgggggt ttggcttcat attgctgaca aaaaaaggaa aaagtacctc      900

aataataaat acagaacttc tcctttcaac ctcttccatc acatcaacac ctatgaagac      960

aatgggtttc tgattgtgga tctctgctgc tggaaaggat ttgagtttgt ttataattac     1020

ttatatttag ccaatttacg tgagaactgg gaagaggtga aaaaaaatgc cagaaaggct     1080

ccccaacctg aagttaggag atatgtactt cctttgaata ttgacaaggc tgacacaggc     1140

aagaatttag tcacgctccc caatacaact gccactgcaa ttctgtgcag tgacgagact     1200

atctggctgg agcctgaagt tctcttttca gggcctcgtc aagcatttga gtttcctcaa     1260

atcaattacc agaagtattg tgggaaacct tacacatatg cgtatggact tggcttgaat     1320

cactttgttc cagataggct ctgtaagctg aatgtcaaaa ctaaagaaac ttgggtttgg     1380

caagagcctg attcataccc atcagaaccc atctttgttt ctcacccaga tgccttggaa     1440

gaagatgatg gtgtagttct gagtgtggtg gtgagcccag gagcaggaca aaagcctgct     1500

tatctcctga ttctgaatgc caaggactta agtgaagttg cccgggctga agtggagatt     1560

aacatccctg tcacctttca tggactgttc aaaaaatctt ga                        1602


<210>  4
<211>  1607
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimised human RPE65 coding sequence

<400>  4
ccaccatgag tatccaggtg gaacatcccg caggggggta taagaaactg tttgagaccg       60

tcgaagaact gagcagccct ctgaccgcac atgtcaccgg aagaatcccc ctgtggctga      120

caggatcact gctgagatgc ggaccaggac tgttcgaagt gggaagcgaa cctttctacc      180

acctgtttga cggacaggcc ctgctgcata agttcgactt caaggagggg cacgtgactt      240

accatcggcg gttcatccga accgacgcct atgtccgggc tatgacagag aagagaatcg      300

tgattactga gttcggcacc tgcgcctttc cagatccctg taagaacatt ttctccaggt      360

tcttttctta ctttcgcggc gtcgaggtga cagacaacgc actggtcaac gtgtaccctg      420

tgggggagga ttactatgcc tgcactgaaa ccaacttcat caccaagatt aatccagaga      480

cactggaaac tatcaaacag gtggacctgt gcaactacgt cagtgtgaat ggcgccaccg      540

ctcaccccca tatcgagaac gatgggacag tctacaacat tggcaattgc ttcgggaaga      600

actttagcat cgcctacaac atcgtgaaga tcccccctct gcaggctgac aaggaggatc      660

ctatctctaa aagtgaaatt gtggtccagt tcccttgttc tgaccggttt aagccaagtt      720

acgtccactc attcggcctg acaccaaact atatcgtctt tgtggagact cccgtgaaga      780

ttaatctgtt caaatttctg agctcctggt ctctgtgggg ggctaactac atggactgct      840

tcgagagtaa tgaaacaatg ggagtgtggc tgcacatcgc agataagaaa cgaaagaaat      900

acctgaacaa taagtaccgg actagcccct tcaacctgtt tcaccatatc aacacctatg      960

aggacaatgg atttctgatt gtcgatctgt gctgttggaa gggcttcgag ttcgtgtaca     1020

actatctgta cctggcaaac ctgcgcgaaa attgggagga agtgaagaaa aatgctcgaa     1080

aagcacctca gccagaagtc aggcgctacg tgctgccact gaacatcgac aaggctgata     1140

caggcaaaaa cctggtgact ctgcccaata ccacagcaac tgccatcctg tgctccgacg     1200

agaccatttg gctggagccc gaagtgctgt tctctggacc tcgccaggcc ttcgaatttc     1260

cacagattaa ttaccagaag tactgcggca aaccctatac ctacgcttat ggactgggcc     1320

tgaaccactt cgtgcctgat agactgtgca agctgaatgt caagaccaaa gagacatggg     1380

tgtggcagga acctgactca taccccagcg agcctatctt tgtgagccat ccagatgccc     1440

tggaggaaga cgatggcgtg gtcctgagcg tggtcgtgtc cccaggagca ggacagaagc     1500

cagcctatct gctgattctg aacgctaaag atctgtccga agtggcaaga gcagaggtgg     1560

agatcaatat cccagtcaca tttcacgggc tgttcaaaaa gtcctaa                   1607


<210>  5
<211>  3000
<212>  DNA
<213>  Homo sapiens

<400>  5
atggggccgg ccccgctgcc gctgctgctg ggcctcttcc tccccgcgct ctggcgtaga       60

gctatcactg aggcaaggga agaagccaag ccttacccgc tattcccggg accttttcca      120

gggagcctgc aaactgacca cacaccgctg ttatcccttc ctcacgccag tgggtaccag      180

cctgccttga tgttttcacc aacccagcct ggaagaccac atacaggaaa cgtagccatt      240

ccccaggtga cctctgtcga atcaaagccc ctaccgcctc ttgccttcaa acacacagtt      300

ggacacataa tactttctga acataaaggt gtcaaattta attgctcaat cagtgtacct      360

aatatatacc aggacaccac aatttcttgg tggaaagatg ggaaggaatt gcttggggca      420

catcatgcaa ttacacagtt ttatccagat gatgaagtta cagcaataat cgcttccttc      480

agcataacca gtgtgcagcg ttcagacaat gggtcgtata tctgtaagat gaaaataaac      540

aatgaagaga tcgtgtctga tcccatctac atcgaagtac aaggacttcc tcactttact      600

aagcagcctg agagcatgaa tgtcaccaga aacacagcct tcaacctcac ctgtcaggct      660

gtgggcccgc ctgagcccgt caacattttc tgggttcaaa acagtagccg tgttaacgaa      720

cagcctgaaa aatccccctc cgtgctaact gttccaggcc tgacggagat ggcggtcttc      780

agttgtgagg cccacaatga caaagggctg accgtgtcca agggagtgca gatcaacatc      840

aaagcaattc cctccccacc aactgaagtc agcatccgta acagcactgc acacagcatt      900

ctgatctcct gggttcctgg ttttgatgga tactccccgt tcaggaattg cagcattcag      960

gtcaaggaag ctgatccgct gagtaatggc tcagtcatga tttttaacac ctctgcctta     1020

ccacatctgt accaaatcaa gcagctgcaa gccctggcta attacagcat tggtgtttcc     1080

tgcatgaatg aaataggctg gtctgcagtg agcccttgga ttctagccag cacgactgaa     1140

ggagccccat cagtagcacc tttaaatgtc actgtgtttc tgaatgaatc tagtgataat     1200

gtggacatca gatggatgaa gcctccgact aagcagcagg atggagaact ggtgggctac     1260

cggatatccc acgtgtggca gagtgcaggg atttccaaag agctcttgga ggaagttggc     1320

cagaatggca gccgagctcg gatctctgtt caagtccaca atgctacgtg cacagtgagg     1380

attgcagccg tcaccagagg gggagttggg cccttcagtg atccagtgaa aatatttatc     1440

cctgcacacg gttgggtaga ttatgccccc tcttcaactc cggcgcctgg caacgcagat     1500

cctgtgctca tcatctttgg ctgcttttgt ggatttattt tgattgggtt gattttatac     1560

atctccttgg ccatcagaaa aagagtccag gagacaaagt ttgggaatgc attcacagag     1620

gaggattctg aattagtggt gaattatata gcaaagaaat ccttctgtcg gcgagccatt     1680

gaacttacct tacatagctt gggagtcagt gaggaactac aaaataaact agaagatgtt     1740

gtgattgaca ggaatcttct aattcttgga aaaattctgg gtgaaggaga gtttgggtct     1800

gtaatggaag gaaatcttaa gcaggaagat gggacctctc tgaaagtggc agtgaagacc     1860

atgaagttgg acaactcttc acagcgggag atcgaggagt ttctcagtga ggcagcgtgc     1920

atgaaagact tcagccaccc aaatgtcatt cgacttctag gtgtgtgtat agaaatgagc     1980

tctcaaggca tcccaaagcc catggtaatt ttacccttca tgaaatacgg ggacctgcat     2040

acttacttac tttattcccg attggagaca ggaccaaagc atattcctct gcagacacta     2100

ttgaagttca tggtggatat tgccctggga atggagtatc tgagcaacag gaattttctt     2160

catcgagatt tagctgctcg aaactgcatg ttgcgagatg acatgactgt ctgtgttgcg     2220

gacttcggcc tctctaagaa gatttacagt ggcgattatt accgccaagg ccgcattgct     2280

aagatgcctg ttaaatggat cgccatagaa agtcttgcag accgagtcta cacaagtaaa     2340

agtgatgtgt gggcatttgg cgtgaccatg tgggaaatag ctacgcgggg aatgactccc     2400

tatcctgggg tccagaacca tgagatgtat gactatcttc tccatggcca caggttgaag     2460

cagcccgaag actgcctgga tgaactgtat gaaataatgt actcttgctg gagaaccgat     2520

cccttagacc gccccacctt ttcagtattg aggctgcagc tagaaaaact cttagaaagt     2580

ttgcctgacg ttcggaacca agcagacgtt atttacgtca atacacagtt gctggagagc     2640

tctgagggcc tggcccaggg ctccaccctt gctccactgg acttgaacat cgaccctgac     2700

tctataattg cctcctgcac tccccgcgct gccatcagtg tggtcacagc agaagttcat     2760

gacagcaaac ctcatgaagg acggtacatc ctgaatgggg gcagtgagga atgggaagat     2820

ctgacttctg ccccctctgc tgcagtcaca gctgaaaaga acagtgtttt accgggggag     2880

agacttgtta ggaatggggt ctcctggtcc cattcgagca tgctgccctt gggaagctca     2940

ttgcccgatg aacttttgtt tgctgacgac tcctcagaag gctcagaagt cctgatgtga     3000


<210>  6
<211>  693
<212>  DNA
<213>  Homo sapiens

<400>  6
atgaagaacc ccatgctgga ggtggtgtct ttactactgg agaagctgct cctcatctcc       60

aacttcacgc tctttagttc gggcgccgcg ggcgaagaca aagggaggaa cagtttttat      120

gaaaccagct ctttccaccg aggcgacgtg ctggaggtgc cccggaccca cctgacccac      180

tatggcatct acctaggaga caaccgtgtt gcccacatga tgcccgacat cctgttggcc      240

ctgacagacg acatggggcg cacgcagaag gtggtctcca acaagcgtct catcctgggc      300

gttattgtca aagtggccag catccgcgtg gacacagtgg aggacttcgc ctacggagct      360

aacatcctgg tcaatcacct ggacgagtcc ctccagaaaa aggcactgct caacgaggag      420

gtggcgcgga gggctgaaaa gctgctgggc tttaccccct acagcctgct gtggaacaac      480

tgcgagcact tcgtgaccta ctgcagatat ggcaccccga tcagtcccca gtccgacaag      540

ttttgtgaga ctgtgaagat aattattcgt gatcagagaa gtgttcttgc ttcagcagtc      600

ttgggattgg cgtctatagt ctgtacgggc ttggtatcat acactaccct tcctgcaatt      660

tttattccat tcttcctatg gatggctggc taa                                   693


<210>  7
<211>  1590
<212>  DNA
<213>  Homo sapiens

<400>  7
atgctcctgg ctgttttgta ctgcctgctg tggagtttcc agacctccgc tggccatttc       60

cctagagcct gtgtctcctc taagaacctg atggagaagg aatgctgtcc accgtggagc      120

ggggacagga gtccctgtgg ccagctttca ggcagaggtt cctgtcagaa tatccttctg      180

tccaatgcac cacttgggcc tcaatttccc ttcacagggg tggatgaccg ggagtcgtgg      240

ccttccgtct tttataatag gacctgccag tgctctggca acttcatggg attcaactgt      300

ggaaactgca agtttggctt ttggggacca aactgcacag agagacgact cttggtgaga      360

agaaacatct tcgatttgag tgccccagag aaggacaaat tttttgccta cctcacttta      420

gcaaagcata ccatcagctc agactatgtc atccccatag ggacctatgg ccaaatgaaa      480

aatggatcaa cacccatgtt taacgacatc aatatttatg acctctttgt ctggatgcat      540

tattatgtgt caatggatgc actgcttggg ggatctgaaa tctggagaga cattgatttt      600

gcccatgaag caccagcttt tctgccttgg catagactct tcttgttgcg gtgggaacaa      660

gaaatccaga agctgacagg agatgaaaac ttcactattc catattggga ctggcgggat      720

gcagaaaagt gtgacatttg cacagatgag tacatgggag gtcagcaccc cacaaatcct      780

aacttactca gcccagcatc attcttctcc tcttggcaga ttgtctgtag ccgattggag      840

gagtacaaca gccatcagtc tttatgcaat ggaacgcccg agggaccttt acggcgtaat      900

cctggaaacc atgacaaatc cagaacccca aggctcccct cttcagctga tgtagaattt      960

tgcctgagtt tgacccaata tgaatctggt tccatggata aagctgccaa tttcagcttt     1020

agaaatacac tggaaggatt tgctagtcca cttactggga tagcggatgc ctctcaaagc     1080

agcatgcaca atgccttgca catctatatg aatggaacaa tgtcccaggt acagggatct     1140

gccaacgatc ctatcttcct tcttcaccat gcatttgttg acagtatttt tgagcagtgg     1200

ctccgaaggc accgtcctct tcaagaagtt tatccagaag ccaatgcacc cattggacat     1260

aaccgggaat cctacatggt tccttttata ccactgtaca gaaatggtga tttctttatt     1320

tcatccaaag atctgggcta tgactatagc tatctacaag attcagaccc agactctttt     1380

caagactaca ttaagtccta tttggaacaa gcgagtcgga tctggtcatg gctccttggg     1440

gcggcgatgg taggggccgt cctcactgcc ctgctggcag ggcttgtgag cttgctgtgt     1500

cgtcacaaga gaaagcagct tcctgaagaa aagcagccac tcctcatgga gaaagaggat     1560

taccacagct tgtatcagag ccatttataa                                      1590


<210>  8
<211>  1275
<212>  DNA
<213>  Homo sapiens

<400>  8
atgacccagg caggccggcg gggtcctggc acacccgagc cgcgtccgcg aacacagccc       60

atggcctccc cgcgcctagg gaccttctgc tgccccacgc gggacgcagc cacgcagctc      120

gtgctgagct tccagccgcg ggccttccac gcgctctgcc tgggcagcgg cgggctccgc      180

ttggcgctgg gccttctgca gctgctgccc ggccgccggc ccgcgggccc cgggtccccc      240

gcgacgtccc cgccggcctc ggtccgcatc ctgcgcgctg ccgctgcctg cgaccttctc      300

ggctgcctgg gtatggtgat ccggtccacc gtgtggttag gattcccaaa ttttgttgac      360

agcgtctcgg atatgaacca cacggaaatt tggcctgctg ctttctgcgt ggggagtgcg      420

atgtggatcc agctgttgta cagtgcctgc ttctggtggc tgttttgcta tgcagtggat      480

gcttatctgg tgatccggag atcggcagga ctgagcacca tcctgctgta tcacatcatg      540

gcgtggggcc tggccaccct gctctgtgtg gagggagccg ccatgctcta ctacccttcc      600

gtgtccaggt gtgagcgggg cctggaccac gccatccccc actatgtcac catgtacctg      660

cccctgctgc tggttctcgt ggcgaacccc atcctgttcc aaaagacagt gactgcagtg      720

gcctctttac ttaaaggaag acaaggcatt tacacggaga acgagaggag gatgggagcc      780

gtgatcaaga tccgattttt caaaatcatg ctggttttaa ttatttgttg gttgtcgaat      840

atcatcaatg aaagcctttt attctatctt gagatgcaaa cagatatcaa tggaggttct      900

ttgaaacctg tcagaactgc agccaagacc acatggttta ttatgggaat cctgaatcca      960

gcccagggat ttctcttgtc tttggccttc tacggctgga caggatgcag cctgggtttt     1020

cagtctccca ggaaggagat ccagtgggaa tcactgacca cctcggctgc tgagggggct     1080

cacccatccc cactgatgcc ccatgaaaac cctgcttccg ggaaggtgtc tcaagtgggt     1140

gggcagactt ctgacgaagc cctgagcatg ctgtctgaag gttctgatgc cagcacaatt     1200

gaaattcaca ctgcaagtga atcctgcaac aaaaatgagg gtgaccctgc tctcccaacc     1260

catggagacc tatga                                                      1275


<210>  9
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  9
aattaccaaa tattgtaaac ggttccatc                                         29


<210>  10
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  10
tgtttgaaac tgtggaggaa ctgtc                                             25


<210>  11
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  11
gaagcgcgat cacatggt                                                     18


<210>  12
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  12
ccatgccgag agtgatcc                                                     18


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
gtggtacgac cagaggcata c                                                 21


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
aaggccaacc gtgaaaagat                                                   20


