                         SEQUENCE LISTING

<110>  TRANSGENE SA
 
<120>  Immunotherapeutic vaccine and antibody combination therapy

<130>  B369862-D35869

<150>  EP15305215.4
<151>  2015-02-13

<150>  EP15305570.2
<151>  2015-04-16

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Ser Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro 
    130                 135                 140                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
145                 150                 155                 160 


Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro 
                165                 170                 175     


Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser 
            180                 185                 190         


Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
        195                 200                 205             


Ala Pro Gly Ser Thr Ala Pro Pro Gly His Gly Val Thr Ser Ala Pro 
    210                 215                 220                 


Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val 
225                 230                 235                 240 


Thr Ser Ala Pro Asp Asn Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro 
                245                 250                 255     


Val His Asn Val Thr Ser Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser 
            260                 265                 270         


Thr Leu Val His Asn Gly Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala 
        275                 280                 285             


Ser Lys Ser Thr Pro Phe Ser Ile Pro Ser His His Ser Asp Thr Pro 
    290                 295                 300                 


Thr Thr Leu Ala Ser His Ser Thr Lys Thr Asp Ala Ser Ser Thr His 
305                 310                 315                 320 


His Ser Thr Val Pro Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro 
                325                 330                 335     


Gln Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser 
            340                 345                 350         


Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr 
        355                 360                 365             


Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys 
    370                 375                 380                 


Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser 
385                 390                 395                 400 


Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn Val 
                405                 410                 415     


His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser 
            420                 425                 430         


Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe 
        435                 440                 445             


Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly Trp Gly Ile Ala 
    450                 455                 460                 


Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala Ile Val Tyr Leu 
465                 470                 475                 480 


Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu 
                485                 490                 495     


Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro 
            500                 505                 510         


Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg 
        515                 520                 525             


Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser 
    530                 535                 540                 


Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn Leu 
545                 550                 555         


<210>  2
<211>  1674
<212>  DNA
<213>  Homo sapiens

<400>  2
atgacaccgg gcacccagtc tcctttcttc ctgctgctgc tcctcacagt gcttacagtt       60

gttacaggtt ctggtcatgc aagctctacc ccaggtggag aaaaggagac ttcggctacc      120

cagagaagtt cagtgcccag ctctactgag aagaatgctg tgagtatgac cagcagcgta      180

ctctccagcc acagccccgg ttcaggctcc tccaccactc agggacagga tgtcactctg      240

gccccggcca cggaaccagc ttcaggttca gctgccacct ggggacagga tgtcacctcg      300

gtcccagtca ccaggccagc cctgggctcc accaccccgc cagcccacga tgtcacctca      360

gccccggaca acaagccagc cccatctcca ggctccaccg cccccccagc ccacggtgtc      420

acctcggccc cggacaccag gccggcacca ggaagcacag caccacccgc gcatggtgta      480

acatctgccc ctgatacacg tcctgctccc ggtagtactg cgccgcctgc acacggggtg      540

acgtctgctc ccgacactcg gccggcgcct gggtcaacgg ctcctccggc acatggagtt      600

acttctgcgc cagacacgcg acccgctcca ggtagtacgg cgccaccggg gcatggagtg      660

acatctgcgc ccgatactag gccggccccg ggctccaccg cccccccagc ccatggtgtc      720

acctcggccc cggacaacag gcccgccttg ggctccaccg cccctccagt ccacaatgtc      780

acctcggcct caggctctgc atcaggctca gcttctactc tggtgcacaa cggcacctct      840

gccagggcta ccacaacccc agccagcaag agcactccat tctcaattcc cagccaccac      900

tctgatactc ctaccaccct tgccagccat agcaccaaga ctgatgccag tagcactcac      960

catagcacgg tacctcctct cacctcctcc aatcacagca cttctcccca gttgtctact     1020

ggggtctctt tctttttcct gtcttttcac atttcaaacc tccagtttaa ttcctctctg     1080

gaagatccca gcaccgacta ctaccaagag ctgcagagag acatttctga aatgtttttg     1140

cagatttata aacaaggggg ttttctgggc ctctccaata ttaagttcag gccaggatct     1200

gtggtggtac aattgactct ggccttccga gaaggtacca tcaatgtcca cgacgtggag     1260

acacagttca atcagtataa aacggaagca gcctctcgat ataacctgac gatctcagac     1320

gtcagcgtga gtgatgtgcc atttcctttc tctgcccagt ctggggctgg ggtgccaggc     1380

tggggcatcg cgctgctggt gctggtctgt gttctggttg cgctggccat tgtctatctc     1440

attgccttgg ctgtctgtca gtgccgccga aagaactacg ggcagctgga catctttcca     1500

gcccgggata cctaccatcc tatgagcgag taccccacct accacaccca tgggcgctat     1560

gtgcccccta gcagtaccga tcgtagcccc tatgagaagg tttctgcagg taatggtggc     1620

agcagcctct cttacacaaa cccagcagtg gcagccactt ctgccaactt gtag           1674


<210>  3
<211>  1047
<212>  PRT
<213>  Escherichia coli

<400>  3

Met Ser Phe Thr Leu Thr Asn Lys Asn Val Ile Phe Val Ala Gly Leu 
1               5                   10                  15      


Gly Gly Ile Gly Leu Asp Thr Ser Lys Glu Leu Leu Lys Arg Asp Pro 
            20                  25                  30          


Val Val Leu Gln Arg Arg Asp Trp Glu Asn Pro Gly Val Thr Gln Leu 
        35                  40                  45              


Asn Arg Leu Ala Ala His Pro Pro Phe Ala Ser Trp Arg Asn Ser Glu 
    50                  55                  60                  


Glu Ala Arg Thr Asp Arg Pro Ser Gln Gln Leu Arg Ser Leu Asn Gly 
65                  70                  75                  80  


Glu Trp Arg Phe Ala Trp Phe Pro Ala Pro Glu Ala Val Pro Glu Ser 
                85                  90                  95      


Trp Leu Glu Cys Asp Leu Pro Glu Ala Asp Thr Val Val Val Pro Ser 
            100                 105                 110         


Asn Trp Gln Met His Gly Tyr Asp Ala Pro Ile Tyr Thr Asn Val Thr 
        115                 120                 125             


Tyr Pro Ile Thr Val Asn Pro Pro Phe Val Pro Thr Glu Asn Pro Thr 
    130                 135                 140                 


Gly Cys Tyr Ser Leu Thr Phe Asn Val Asp Glu Ser Trp Leu Gln Glu 
145                 150                 155                 160 


Gly Gln Thr Arg Ile Ile Phe Asp Gly Val Asn Ser Ala Phe His Leu 
                165                 170                 175     


Trp Cys Asn Gly Arg Trp Val Gly Tyr Gly Gln Asp Ser Arg Leu Pro 
            180                 185                 190         


Ser Glu Phe Asp Leu Ser Ala Phe Leu Arg Ala Gly Glu Asn Arg Leu 
        195                 200                 205             


Ala Val Met Val Leu Arg Trp Ser Asp Gly Ser Tyr Leu Glu Asp Gln 
    210                 215                 220                 


Asp Met Trp Arg Met Ser Gly Ile Phe Arg Asp Val Ser Leu Leu His 
225                 230                 235                 240 


Lys Pro Thr Thr Gln Ile Ser Asp Phe His Val Ala Thr Arg Phe Asn 
                245                 250                 255     


Asp Asp Phe Ser Arg Ala Val Leu Glu Ala Glu Val Gln Met Cys Gly 
            260                 265                 270         


Glu Leu Arg Asp Tyr Leu Arg Val Thr Val Ser Leu Trp Gln Gly Glu 
        275                 280                 285             


Thr Gln Val Ala Ser Gly Thr Ala Pro Phe Gly Gly Glu Ile Ile Asp 
    290                 295                 300                 


Glu Arg Gly Gly Tyr Ala Asp Arg Val Thr Leu Arg Leu Asn Val Glu 
305                 310                 315                 320 


Asn Pro Lys Leu Trp Ser Ala Glu Ile Pro Asn Leu Tyr Arg Ala Val 
                325                 330                 335     


Val Glu Leu His Thr Ala Asp Gly Thr Leu Ile Glu Ala Glu Ala Cys 
            340                 345                 350         


Asp Val Gly Phe Arg Glu Val Arg Ile Glu Asn Gly Leu Leu Leu Leu 
        355                 360                 365             


Asn Gly Lys Pro Leu Leu Ile Arg Gly Val Asn Arg His Glu His His 
    370                 375                 380                 


Pro Leu His Gly Gln Val Met Asp Glu Gln Thr Met Val Gln Asp Ile 
385                 390                 395                 400 


Leu Leu Met Lys Gln Asn Asn Phe Asn Ala Val Arg Cys Ser His Tyr 
                405                 410                 415     


Pro Asn His Pro Leu Trp Tyr Thr Leu Cys Asp Arg Tyr Gly Leu Tyr 
            420                 425                 430         


Val Val Asp Glu Ala Asn Ile Glu Thr His Gly Met Val Pro Met Asn 
        435                 440                 445             


Arg Leu Thr Asp Asp Pro Arg Trp Leu Pro Ala Met Ser Glu Arg Val 
    450                 455                 460                 


Thr Arg Met Val Gln Arg Asp Arg Asn His Pro Ser Val Ile Ile Trp 
465                 470                 475                 480 


Ser Leu Gly Asn Glu Ser Gly His Gly Ala Asn His Asp Ala Leu Tyr 
                485                 490                 495     


Arg Trp Ile Lys Ser Val Asp Pro Ser Arg Pro Val Gln Tyr Glu Gly 
            500                 505                 510         


Gly Gly Ala Asp Thr Thr Ala Thr Asp Ile Ile Cys Pro Met Tyr Ala 
        515                 520                 525             


Arg Val Asp Glu Asp Gln Pro Phe Pro Ala Val Pro Lys Trp Ser Ile 
    530                 535                 540                 


Lys Lys Trp Leu Ser Leu Pro Gly Glu Thr Arg Pro Leu Ile Leu Cys 
545                 550                 555                 560 


Glu Tyr Ala His Ala Met Gly Asn Ser Leu Gly Gly Phe Ala Lys Tyr 
                565                 570                 575     


Trp Gln Ala Phe Arg Gln Tyr Pro Arg Leu Gln Gly Gly Phe Val Trp 
            580                 585                 590         


Asp Trp Val Asp Gln Ser Leu Ile Lys Tyr Asp Glu Asn Gly Asn Pro 
        595                 600                 605             


Trp Ser Ala Tyr Gly Gly Asp Phe Gly Asp Thr Pro Asn Asp Arg Gln 
    610                 615                 620                 


Phe Cys Met Asn Gly Leu Val Phe Ala Asp Arg Thr Pro His Pro Ala 
625                 630                 635                 640 


Leu Thr Glu Ala Lys His Gln Gln Gln Phe Phe Gln Phe Arg Leu Ser 
                645                 650                 655     


Gly Gln Thr Ile Glu Val Thr Ser Glu Tyr Leu Phe Arg His Ser Asp 
            660                 665                 670         


Asn Glu Leu Leu His Trp Met Val Ala Leu Asp Gly Lys Pro Leu Ala 
        675                 680                 685             


Ser Gly Glu Val Pro Leu Asp Val Ala Pro Gln Gly Lys Gln Leu Ile 
    690                 695                 700                 


Glu Leu Pro Glu Leu Pro Gln Pro Glu Ser Ala Gly Gln Leu Trp Leu 
705                 710                 715                 720 


Thr Val Arg Val Val Gln Pro Asn Ala Thr Ala Trp Ser Glu Ala Gly 
                725                 730                 735     


His Ile Ser Ala Trp Gln Gln Trp Arg Leu Ala Glu Asn Leu Ser Val 
            740                 745                 750         


Thr Leu Pro Ala Ala Ser His Ala Ile Pro His Leu Thr Thr Ser Glu 
        755                 760                 765             


Met Asp Phe Cys Ile Glu Leu Gly Asn Lys Arg Trp Gln Phe Asn Arg 
    770                 775                 780                 


Gln Ser Gly Phe Leu Ser Gln Met Trp Ile Gly Asp Lys Lys Gln Leu 
785                 790                 795                 800 


Leu Thr Pro Leu Arg Asp Gln Phe Thr Arg Ala Pro Leu Asp Asn Asp 
                805                 810                 815     


Ile Gly Val Ser Glu Ala Thr Arg Ile Asp Pro Asn Ala Trp Val Glu 
            820                 825                 830         


Arg Trp Lys Ala Ala Gly His Tyr Gln Ala Glu Ala Ala Leu Leu Gln 
        835                 840                 845             


Cys Thr Ala Asp Thr Leu Ala Asp Ala Val Leu Ile Thr Thr Ala His 
    850                 855                 860                 


Ala Trp Gln His Gln Gly Lys Thr Leu Phe Ile Ser Arg Lys Thr Tyr 
865                 870                 875                 880 


Arg Ile Asp Gly Ser Gly Gln Met Ala Ile Thr Val Asp Val Glu Val 
                885                 890                 895     


Ala Ser Asp Thr Pro His Pro Ala Arg Ile Gly Leu Asn Cys Gln Leu 
            900                 905                 910         


Ala Gln Val Ala Glu Arg Val Asn Trp Leu Gly Leu Gly Pro Gln Glu 
        915                 920                 925             


Asn Tyr Pro Asp Arg Leu Thr Ala Ala Cys Phe Asp Arg Trp Asp Leu 
    930                 935                 940                 


Pro Leu Ser Asp Met Tyr Thr Pro Tyr Val Phe Pro Ser Glu Asn Gly 
945                 950                 955                 960 


Leu Arg Cys Gly Thr Arg Glu Leu Asn Tyr Gly Pro His Gln Trp Arg 
                965                 970                 975     


Gly Asp Phe Gln Phe Asn Ile Ser Arg Tyr Ser Gln Gln Gln Leu Met 
            980                 985                 990         


Glu Thr Ser His Arg His Leu Leu  His Ala Glu Glu Gly  Thr Trp Leu 
        995                 1000                 1005             


Asn Ile  Asp Gly Phe His Met  Gly Ile Gly Gly Asp  Asp Ser Trp 
    1010                 1015                 1020             


Ser Pro  Ser Val Ser Ala Glu  Leu Gln Leu Ser Ala  Gly Arg Tyr 
    1025                 1030                 1035             


His Tyr  Gln Leu Val Trp Cys  Gln Lys 
    1040                 1045         


<210>  4
<211>  114
<212>  DNA
<213>  Vaccinia virus

<400>  4
tttattctat acttaaaaaa tgaaaataaa tacaaaggtt cttgagggtt gtgttaaatt       60

gaaagcgaga aataatcata aattatttca ttatcgcgat atccgttaag tttg            114


<210>  5
<211>  46
<212>  DNA
<213>  artificial sequence

<220>
<223>  PCR primer for LacZ cloning

<400>  5
ccaccttaat taagccgcca ccatgtcgtt tactttgacc aacaag                      46


<210>  6
<211>  43
<212>  DNA
<213>  artificial sequence

<220>
<223>  PCR primer for LacZ cloning

<400>  6
accaactcga gagaaaaatt atttttgaca ccagaccaac tgg                         43


