                         SEQUENCE LISTING

<110>  Alma Mater Studiorum Universita di Bologna
 
<120>  RETARGETED HERPESVIRUS WITH A GLYCOPROTEIN H FUSION

<130>  854-7 PCT

<150>  EP15425012.0
<151>  11.02.2015

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  838
<212>  PRT
<213>  HSV-1

<400>  1

Met Gly Asn Gly Leu Trp Phe Val Gly Val Ile Ile Leu Gly Val Ala 
1               5                   10                  15      


Trp Gly Gln Val His Asp Trp Thr Glu Gln Thr Asp Pro Trp Phe Leu 
            20                  25                  30          


Asp Gly Leu Gly Met Asp Arg Met Tyr Trp Arg Asp Thr Asn Thr Gly 
        35                  40                  45              


Arg Leu Trp Leu Pro Asn Thr Pro Asp Pro Gln Lys Pro Pro Arg Gly 
    50                  55                  60                  


Phe Leu Ala Pro Pro Asp Glu Leu Asn Leu Thr Thr Ala Ser Leu Pro 
65                  70                  75                  80  


Leu Leu Arg Trp Tyr Glu Glu Arg Phe Cys Phe Val Leu Val Thr Thr 
                85                  90                  95      


Ala Glu Phe Pro Arg Asp Pro Gly Gln Leu Leu Tyr Ile Pro Lys Thr 
            100                 105                 110         


Tyr Leu Leu Gly Arg Pro Pro Asn Ala Ser Leu Pro Ala Pro Thr Thr 
        115                 120                 125             


Val Glu Pro Thr Ala Gln Pro Pro Pro Ser Val Ala Pro Leu Lys Gly 
    130                 135                 140                 


Leu Leu Tyr Asn Pro Val Ala Ser Val Leu Leu Arg Ser Arg Ala Trp 
145                 150                 155                 160 


Val Thr Phe Ser Ala Val Pro Asp Pro Glu Ala Leu Thr Phe Pro Arg 
                165                 170                 175     


Gly Asp Asn Val Ala Thr Ala Ser His Pro Ser Gly Pro Arg Asp Thr 
            180                 185                 190         


Pro Pro Pro Arg Pro Pro Val Gly Ala Arg Arg His Pro Thr Thr Glu 
        195                 200                 205             


Leu Asp Ile Thr His Leu His Asn Ala Ser Thr Thr Trp Leu Ala Thr 
    210                 215                 220                 


Arg Gly Leu Leu Arg Ser Pro Gly Arg Tyr Val Tyr Phe Ser Pro Ser 
225                 230                 235                 240 


Ala Ser Thr Trp Pro Val Gly Ile Trp Thr Thr Gly Glu Leu Val Leu 
                245                 250                 255     


Gly Cys Asp Ala Ala Leu Val Arg Ala Arg Tyr Gly Arg Glu Phe Met 
            260                 265                 270         


Gly Leu Val Ile Ser Met His Asp Ser Pro Pro Val Glu Val Met Val 
        275                 280                 285             


Val Pro Ala Gly Gln Thr Leu Asp Arg Val Gly Asp Pro Ala Asp Glu 
    290                 295                 300                 


Asn Pro Pro Gly Ala Leu Pro Gly Pro Pro Gly Gly Pro Arg Tyr Arg 
305                 310                 315                 320 


Val Phe Val Leu Gly Ser Leu Thr Arg Ala Asp Asn Gly Ser Ala Leu 
                325                 330                 335     


Asp Ala Leu Arg Arg Val Gly Gly Tyr Pro Glu Glu Gly Thr Asn Tyr 
            340                 345                 350         


Ala Gln Phe Leu Ser Arg Ala Tyr Ala Glu Phe Phe Ser Gly Asp Ala 
        355                 360                 365             


Gly Ala Glu Gln Gly Pro Arg Pro Pro Leu Phe Trp Arg Leu Thr Gly 
    370                 375                 380                 


Leu Leu Ala Thr Ser Gly Phe Ala Phe Val Asn Ala Ala His Ala Asn 
385                 390                 395                 400 


Gly Ala Val Cys Leu Ser Asp Leu Leu Gly Phe Leu Ala His Ser Arg 
                405                 410                 415     


Ala Leu Ala Gly Leu Ala Ala Arg Gly Ala Ala Gly Cys Ala Ala Asp 
            420                 425                 430         


Ser Val Phe Phe Asn Val Ser Val Leu Asp Pro Thr Ala Arg Leu Gln 
        435                 440                 445             


Leu Glu Ala Arg Leu Gln His Leu Val Ala Glu Ile Leu Glu Arg Glu 
    450                 455                 460                 


Gln Ser Leu Ala Leu His Ala Leu Gly Tyr Gln Leu Ala Phe Val Leu 
465                 470                 475                 480 


Asp Ser Pro Ser Ala Tyr Asp Ala Val Ala Pro Ser Ala Ala His Leu 
                485                 490                 495     


Ile Asp Ala Leu Tyr Ala Glu Phe Leu Gly Gly Arg Val Leu Thr Thr 
            500                 505                 510         


Pro Val Val His Arg Ala Leu Phe Tyr Ala Ser Ala Val Leu Arg Gln 
        515                 520                 525             


Pro Phe Leu Ala Gly Val Pro Ser Ala Val Gln Arg Glu Arg Ala Arg 
    530                 535                 540                 


Arg Ser Leu Leu Ile Ala Ser Ala Leu Cys Thr Ser Asp Val Ala Ala 
545                 550                 555                 560 


Ala Thr Asn Ala Asp Leu Arg Thr Ala Leu Ala Arg Ala Asp His Gln 
                565                 570                 575     


Lys Thr Leu Phe Trp Leu Pro Asp His Phe Ser Pro Cys Ala Ala Ser 
            580                 585                 590         


Leu Arg Phe Asp Leu Asp Glu Ser Val Phe Ile Leu Asp Ala Leu Ala 
        595                 600                 605             


Gln Ala Thr Arg Ser Glu Thr Pro Val Glu Val Leu Ala Gln Gln Thr 
    610                 615                 620                 


His Gly Leu Ala Ser Thr Leu Thr Arg Trp Ala His Tyr Asn Ala Leu 
625                 630                 635                 640 


Ile Arg Ala Phe Val Pro Glu Ala Ser His Arg Cys Gly Gly Gln Ser 
                645                 650                 655     


Ala Asn Val Glu Pro Arg Ile Leu Val Pro Ile Thr His Asn Ala Ser 
            660                 665                 670         


Tyr Val Val Thr His Ser Pro Leu Pro Arg Gly Ile Gly Tyr Lys Leu 
        675                 680                 685             


Thr Gly Val Asp Val Arg Arg Pro Leu Phe Leu Thr Tyr Leu Thr Ala 
    690                 695                 700                 


Thr Cys Glu Gly Ser Thr Arg Asp Ile Glu Ser Lys Arg Leu Val Arg 
705                 710                 715                 720 


Thr Gln Asn Gln Arg Asp Leu Gly Leu Val Gly Ala Val Phe Met Arg 
                725                 730                 735     


Tyr Thr Pro Ala Gly Glu Val Met Ser Val Leu Leu Val Asp Thr Asp 
            740                 745                 750         


Asn Thr Gln Gln Gln Ile Ala Ala Gly Pro Thr Glu Gly Ala Pro Ser 
        755                 760                 765             


Val Phe Ser Ser Asp Val Pro Ser Thr Ala Leu Leu Leu Phe Pro Asn 
    770                 775                 780                 


Gly Thr Val Ile His Leu Leu Ala Phe Asp Thr Gln Pro Val Ala Ala 
785                 790                 795                 800 


Ile Ala Pro Gly Phe Leu Ala Ala Ser Ala Leu Gly Val Val Met Ile 
                805                 810                 815     


Thr Ala Ala Leu Ala Gly Ile Leu Lys Val Leu Arg Thr Ser Val Pro 
            820                 825                 830         


Phe Phe Trp Arg Arg Glu 
        835             


<210>  2
<211>  1105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gH as in construct R-VG803, R-VG805 and R-VG809

<400>  2

Met Gly Asn Gly Leu Trp Phe Val Gly Val Ile Ile Leu Gly Val Ala 
1               5                   10                  15      


Trp Gly Gln Val His Asp Trp His Ser Ser Gly Gly Gly Ser Gly Ser 
            20                  25                  30          


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
        35                  40                  45              


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
    50                  55                  60                  


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
65                  70                  75                  80  


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
                85                  90                  95      


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
            100                 105                 110         


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
        115                 120                 125             


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Asp Met Pro Met 
    130                 135                 140                 


Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Val Phe His Ser Glu 
145                 150                 155                 160 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
            180                 185                 190         


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        195                 200                 205             


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                245                 250                 255     


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Ser Gly Gly 
        275                 280                 285             


Ser Gly Thr Glu Gln Thr Asp Pro Trp Phe Leu Asp Gly Leu Gly Met 
    290                 295                 300                 


Asp Arg Met Tyr Trp Arg Asp Thr Asn Thr Gly Arg Leu Trp Leu Pro 
305                 310                 315                 320 


Asn Thr Pro Asp Pro Gln Lys Pro Pro Arg Gly Phe Leu Ala Pro Pro 
                325                 330                 335     


Asp Glu Leu Asn Leu Thr Thr Ala Ser Leu Pro Leu Leu Arg Trp Tyr 
            340                 345                 350         


Glu Glu Arg Phe Cys Phe Val Leu Val Thr Thr Ala Glu Phe Pro Arg 
        355                 360                 365             


Asp Pro Gly Gln Leu Leu Tyr Ile Pro Lys Thr Tyr Leu Leu Gly Arg 
    370                 375                 380                 


Pro Pro Asn Ala Ser Leu Pro Ala Pro Thr Thr Val Glu Pro Thr Ala 
385                 390                 395                 400 


Gln Pro Pro Pro Ser Val Ala Pro Leu Lys Gly Leu Leu Tyr Asn Pro 
                405                 410                 415     


Val Ala Ser Val Leu Leu Arg Ser Arg Ala Trp Val Thr Phe Ser Ala 
            420                 425                 430         


Val Pro Asp Pro Glu Ala Leu Thr Phe Pro Arg Gly Asp Asn Val Ala 
        435                 440                 445             


Thr Ala Ser His Pro Ser Gly Pro Arg Asp Thr Pro Pro Pro Arg Pro 
    450                 455                 460                 


Pro Val Gly Ala Arg Arg His Pro Thr Thr Glu Leu Asp Ile Thr His 
465                 470                 475                 480 


Leu His Asn Ala Ser Thr Thr Trp Leu Ala Thr Arg Gly Leu Leu Arg 
                485                 490                 495     


Ser Pro Gly Arg Tyr Val Tyr Phe Ser Pro Ser Ala Ser Thr Trp Pro 
            500                 505                 510         


Val Gly Ile Trp Thr Thr Gly Glu Leu Val Leu Gly Cys Asp Ala Ala 
        515                 520                 525             


Leu Val Arg Ala Arg Tyr Gly Arg Glu Phe Met Gly Leu Val Ile Ser 
    530                 535                 540                 


Met His Asp Ser Pro Pro Val Glu Val Met Val Val Pro Ala Gly Gln 
545                 550                 555                 560 


Thr Leu Asp Arg Val Gly Asp Pro Ala Asp Glu Asn Pro Pro Gly Ala 
                565                 570                 575     


Leu Pro Gly Pro Pro Gly Gly Pro Arg Tyr Arg Val Phe Val Leu Gly 
            580                 585                 590         


Ser Leu Thr Arg Ala Asp Asn Gly Ser Ala Leu Asp Ala Leu Arg Arg 
        595                 600                 605             


Val Gly Gly Tyr Pro Glu Glu Gly Thr Asn Tyr Ala Gln Phe Leu Ser 
    610                 615                 620                 


Arg Ala Tyr Ala Glu Phe Phe Ser Gly Asp Ala Gly Ala Glu Gln Gly 
625                 630                 635                 640 


Pro Arg Pro Pro Leu Phe Trp Arg Leu Thr Gly Leu Leu Ala Thr Ser 
                645                 650                 655     


Gly Phe Ala Phe Val Asn Ala Ala His Ala Asn Gly Ala Val Cys Leu 
            660                 665                 670         


Ser Asp Leu Leu Gly Phe Leu Ala His Ser Arg Ala Leu Ala Gly Leu 
        675                 680                 685             


Ala Ala Arg Gly Ala Ala Gly Cys Ala Ala Asp Ser Val Phe Phe Asn 
    690                 695                 700                 


Val Ser Val Leu Asp Pro Thr Ala Arg Leu Gln Leu Glu Ala Arg Leu 
705                 710                 715                 720 


Gln His Leu Val Ala Glu Ile Leu Glu Arg Glu Gln Ser Leu Ala Leu 
                725                 730                 735     


His Ala Leu Gly Tyr Gln Leu Ala Phe Val Leu Asp Ser Pro Ser Ala 
            740                 745                 750         


Tyr Asp Ala Val Ala Pro Ser Ala Ala His Leu Ile Asp Ala Leu Tyr 
        755                 760                 765             


Ala Glu Phe Leu Gly Gly Arg Val Leu Thr Thr Pro Val Val His Arg 
    770                 775                 780                 


Ala Leu Phe Tyr Ala Ser Ala Val Leu Arg Gln Pro Phe Leu Ala Gly 
785                 790                 795                 800 


Val Pro Ser Ala Val Gln Arg Glu Arg Ala Arg Arg Ser Leu Leu Ile 
                805                 810                 815     


Ala Ser Ala Leu Cys Thr Ser Asp Val Ala Ala Ala Thr Asn Ala Asp 
            820                 825                 830         


Leu Arg Thr Ala Leu Ala Arg Ala Asp His Gln Lys Thr Leu Phe Trp 
        835                 840                 845             


Leu Pro Asp His Phe Ser Pro Cys Ala Ala Ser Leu Arg Phe Asp Leu 
    850                 855                 860                 


Asp Glu Ser Val Phe Ile Leu Asp Ala Leu Ala Gln Ala Thr Arg Ser 
865                 870                 875                 880 


Glu Thr Pro Val Glu Val Leu Ala Gln Gln Thr His Gly Leu Ala Ser 
                885                 890                 895     


Thr Leu Thr Arg Trp Ala His Tyr Asn Ala Leu Ile Arg Ala Phe Val 
            900                 905                 910         


Pro Glu Ala Ser His Arg Cys Gly Gly Gln Ser Ala Asn Val Glu Pro 
        915                 920                 925             


Arg Ile Leu Val Pro Ile Thr His Asn Ala Ser Tyr Val Val Thr His 
    930                 935                 940                 


Ser Pro Leu Pro Arg Gly Ile Gly Tyr Lys Leu Thr Gly Val Asp Val 
945                 950                 955                 960 


Arg Arg Pro Leu Phe Leu Thr Tyr Leu Thr Ala Thr Cys Glu Gly Ser 
                965                 970                 975     


Thr Arg Asp Ile Glu Ser Lys Arg Leu Val Arg Thr Gln Asn Gln Arg 
            980                 985                 990         


Asp Leu Gly Leu Val Gly Ala Val  Phe Met Arg Tyr Thr  Pro Ala Gly 
        995                 1000                 1005             


Glu Val  Met Ser Val Leu Leu  Val Asp Thr Asp Asn  Thr Gln Gln 
    1010                 1015                 1020             


Gln Ile  Ala Ala Gly Pro Thr  Glu Gly Ala Pro Ser  Val Phe Ser 
    1025                 1030                 1035             


Ser Asp  Val Pro Ser Thr Ala  Leu Leu Leu Phe Pro  Asn Gly Thr 
    1040                 1045                 1050             


Val Ile  His Leu Leu Ala Phe  Asp Thr Gln Pro Val  Ala Ala Ile 
    1055                 1060                 1065             


Ala Pro  Gly Phe Leu Ala Ala  Ser Ala Leu Gly Val  Val Met Ile 
    1070                 1075                 1080             


Thr Ala  Ala Leu Ala Gly Ile  Leu Lys Val Leu Arg  Thr Ser Val 
    1085                 1090                 1095             


Pro Phe  Phe Trp Arg Arg Glu  
    1100                 1105 


<210>  3
<211>  1081
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gH as in construct R-VG811

<400>  3

Met Gly Asn Gly Leu Trp Phe Val Gly Val Ile Ile Leu Gly Val Ala 
1               5                   10                  15      


Trp Gly Gln Val His Asp Trp His Ser Ser Gly Gly Gly Ser Gly Ser 
            20                  25                  30          


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
        35                  40                  45              


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
    50                  55                  60                  


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
65                  70                  75                  80  


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
                85                  90                  95      


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
            100                 105                 110         


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
        115                 120                 125             


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Asp Met Pro Met 
    130                 135                 140                 


Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Val Phe His Ser Glu 
145                 150                 155                 160 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
            180                 185                 190         


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        195                 200                 205             


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                245                 250                 255     


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Ser Gly Gly 
        275                 280                 285             


Ser Gly Gly Arg Leu Trp Leu Pro Asn Thr Pro Asp Pro Gln Lys Pro 
    290                 295                 300                 


Pro Arg Gly Phe Leu Ala Pro Pro Asp Glu Leu Asn Leu Thr Thr Ala 
305                 310                 315                 320 


Ser Leu Pro Leu Leu Arg Trp Tyr Glu Glu Arg Phe Cys Phe Val Leu 
                325                 330                 335     


Val Thr Thr Ala Glu Phe Pro Arg Asp Pro Gly Gln Leu Leu Tyr Ile 
            340                 345                 350         


Pro Lys Thr Tyr Leu Leu Gly Arg Pro Pro Asn Ala Ser Leu Pro Ala 
        355                 360                 365             


Pro Thr Thr Val Glu Pro Thr Ala Gln Pro Pro Pro Ser Val Ala Pro 
    370                 375                 380                 


Leu Lys Gly Leu Leu Tyr Asn Pro Val Ala Ser Val Leu Leu Arg Ser 
385                 390                 395                 400 


Arg Ala Trp Val Thr Phe Ser Ala Val Pro Asp Pro Glu Ala Leu Thr 
                405                 410                 415     


Phe Pro Arg Gly Asp Asn Val Ala Thr Ala Ser His Pro Ser Gly Pro 
            420                 425                 430         


Arg Asp Thr Pro Pro Pro Arg Pro Pro Val Gly Ala Arg Arg His Pro 
        435                 440                 445             


Thr Thr Glu Leu Asp Ile Thr His Leu His Asn Ala Ser Thr Thr Trp 
    450                 455                 460                 


Leu Ala Thr Arg Gly Leu Leu Arg Ser Pro Gly Arg Tyr Val Tyr Phe 
465                 470                 475                 480 


Ser Pro Ser Ala Ser Thr Trp Pro Val Gly Ile Trp Thr Thr Gly Glu 
                485                 490                 495     


Leu Val Leu Gly Cys Asp Ala Ala Leu Val Arg Ala Arg Tyr Gly Arg 
            500                 505                 510         


Glu Phe Met Gly Leu Val Ile Ser Met His Asp Ser Pro Pro Val Glu 
        515                 520                 525             


Val Met Val Val Pro Ala Gly Gln Thr Leu Asp Arg Val Gly Asp Pro 
    530                 535                 540                 


Ala Asp Glu Asn Pro Pro Gly Ala Leu Pro Gly Pro Pro Gly Gly Pro 
545                 550                 555                 560 


Arg Tyr Arg Val Phe Val Leu Gly Ser Leu Thr Arg Ala Asp Asn Gly 
                565                 570                 575     


Ser Ala Leu Asp Ala Leu Arg Arg Val Gly Gly Tyr Pro Glu Glu Gly 
            580                 585                 590         


Thr Asn Tyr Ala Gln Phe Leu Ser Arg Ala Tyr Ala Glu Phe Phe Ser 
        595                 600                 605             


Gly Asp Ala Gly Ala Glu Gln Gly Pro Arg Pro Pro Leu Phe Trp Arg 
    610                 615                 620                 


Leu Thr Gly Leu Leu Ala Thr Ser Gly Phe Ala Phe Val Asn Ala Ala 
625                 630                 635                 640 


His Ala Asn Gly Ala Val Cys Leu Ser Asp Leu Leu Gly Phe Leu Ala 
                645                 650                 655     


His Ser Arg Ala Leu Ala Gly Leu Ala Ala Arg Gly Ala Ala Gly Cys 
            660                 665                 670         


Ala Ala Asp Ser Val Phe Phe Asn Val Ser Val Leu Asp Pro Thr Ala 
        675                 680                 685             


Arg Leu Gln Leu Glu Ala Arg Leu Gln His Leu Val Ala Glu Ile Leu 
    690                 695                 700                 


Glu Arg Glu Gln Ser Leu Ala Leu His Ala Leu Gly Tyr Gln Leu Ala 
705                 710                 715                 720 


Phe Val Leu Asp Ser Pro Ser Ala Tyr Asp Ala Val Ala Pro Ser Ala 
                725                 730                 735     


Ala His Leu Ile Asp Ala Leu Tyr Ala Glu Phe Leu Gly Gly Arg Val 
            740                 745                 750         


Leu Thr Thr Pro Val Val His Arg Ala Leu Phe Tyr Ala Ser Ala Val 
        755                 760                 765             


Leu Arg Gln Pro Phe Leu Ala Gly Val Pro Ser Ala Val Gln Arg Glu 
    770                 775                 780                 


Arg Ala Arg Arg Ser Leu Leu Ile Ala Ser Ala Leu Cys Thr Ser Asp 
785                 790                 795                 800 


Val Ala Ala Ala Thr Asn Ala Asp Leu Arg Thr Ala Leu Ala Arg Ala 
                805                 810                 815     


Asp His Gln Lys Thr Leu Phe Trp Leu Pro Asp His Phe Ser Pro Cys 
            820                 825                 830         


Ala Ala Ser Leu Arg Phe Asp Leu Asp Glu Ser Val Phe Ile Leu Asp 
        835                 840                 845             


Ala Leu Ala Gln Ala Thr Arg Ser Glu Thr Pro Val Glu Val Leu Ala 
    850                 855                 860                 


Gln Gln Thr His Gly Leu Ala Ser Thr Leu Thr Arg Trp Ala His Tyr 
865                 870                 875                 880 


Asn Ala Leu Ile Arg Ala Phe Val Pro Glu Ala Ser His Arg Cys Gly 
                885                 890                 895     


Gly Gln Ser Ala Asn Val Glu Pro Arg Ile Leu Val Pro Ile Thr His 
            900                 905                 910         


Asn Ala Ser Tyr Val Val Thr His Ser Pro Leu Pro Arg Gly Ile Gly 
        915                 920                 925             


Tyr Lys Leu Thr Gly Val Asp Val Arg Arg Pro Leu Phe Leu Thr Tyr 
    930                 935                 940                 


Leu Thr Ala Thr Cys Glu Gly Ser Thr Arg Asp Ile Glu Ser Lys Arg 
945                 950                 955                 960 


Leu Val Arg Thr Gln Asn Gln Arg Asp Leu Gly Leu Val Gly Ala Val 
                965                 970                 975     


Phe Met Arg Tyr Thr Pro Ala Gly Glu Val Met Ser Val Leu Leu Val 
            980                 985                 990         


Asp Thr Asp Asn Thr Gln Gln Gln  Ile Ala Ala Gly Pro  Thr Glu Gly 
        995                 1000                 1005             


Ala Pro  Ser Val Phe Ser Ser  Asp Val Pro Ser Thr  Ala Leu Leu 
    1010                 1015                 1020             


Leu Phe  Pro Asn Gly Thr Val  Ile His Leu Leu Ala  Phe Asp Thr 
    1025                 1030                 1035             


Gln Pro  Val Ala Ala Ile Ala  Pro Gly Phe Leu Ala  Ala Ser Ala 
    1040                 1045                 1050             


Leu Gly  Val Val Met Ile Thr  Ala Ala Leu Ala Gly  Ile Leu Lys 
    1055                 1060                 1065             


Val Leu  Arg Thr Ser Val Pro  Phe Phe Trp Arg Arg  Glu 
    1070                 1075                 1080     


<210>  4
<211>  394
<212>  PRT
<213>  HSV-1

<400>  4

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Asp Ala 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asp Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Arg Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Ala Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


Asn Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp 
            100                 105                 110         


Val Arg Lys Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly 
        115                 120                 125             


Gly Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Asn Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Lys Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ser Ala Cys Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Val Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Val Gly Thr Val Ala Pro Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr 
                325                 330                 335     


Pro Asn Asn Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu 
            340                 345                 350         


Ala Ala Leu Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr 
        355                 360                 365             


Gln Lys Ala Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp 
    370                 375                 380                 


Gln Pro Ser Ser His Gln Pro Leu Phe Tyr 
385                 390                 


<210>  5
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gD as in R-LM113

<400>  5

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Glu Asn 
            20                  25                  30          


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
        35                  40                  45              


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr 
    50                  55                  60                  


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
65                  70                  75                  80  


Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
                85                  90                  95      


Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
            100                 105                 110         


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro 
        115                 120                 125             


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Asp Met Pro 
    130                 135                 140                 


Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Val Phe His Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            180                 185                 190         


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    210                 215                 220                 


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Ser Gly 
        275                 280                 285             


Gly Ser His Ile Gln Ala Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser 
    290                 295                 300                 


Leu Pro Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser 
305                 310                 315                 320 


Val Leu Leu Asn Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala 
                325                 330                 335     


Ser Glu Asp Val Arg Lys Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe 
            340                 345                 350         


Arg Met Gly Gly Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr 
        355                 360                 365             


Glu Cys Ser Tyr Asn Lys Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln 
    370                 375                 380                 


Pro Arg Trp Asn Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn 
385                 390                 395                 400 


Leu Gly Phe Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr 
                405                 410                 415     


Leu Arg Leu Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile 
            420                 425                 430         


Leu Glu His Arg Ala Lys Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg 
        435                 440                 445             


Ile Pro Pro Ser Ala Cys Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val 
    450                 455                 460                 


Thr Val Asp Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln 
465                 470                 475                 480 


Arg Thr Val Ala Val Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro 
                485                 490                 495     


Lys Ala Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr 
            500                 505                 510         


Pro Asn Ala Thr Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser 
        515                 520                 525             


Ala Leu Leu Glu Asp Pro Val Gly Thr Val Ala Pro Gln Ile Pro Pro 
    530                 535                 540                 


Asn Trp His Ile Pro Ser Ile Gln Asp Ala Ala Thr Pro Tyr His Pro 
545                 550                 555                 560 


Pro Ala Thr Pro Asn Asn Met Gly Leu Ile Ala Gly Ala Val Gly Gly 
                565                 570                 575     


Ser Leu Leu Ala Ala Leu Val Ile Cys Gly Ile Val Tyr Trp Met Arg 
            580                 585                 590         


Arg Arg Thr Gln Lys Ala Pro Lys Arg Ile Arg Leu Pro His Ile Arg 
        595                 600                 605             


Glu Asp Asp Gln Pro Ser Ser His Gln Pro Leu Phe Tyr 
    610                 615                 620     


<210>  6
<211>  503
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gD as in R-LM249

<400>  6

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Asp Ala 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asp Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Arg Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Ala Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala His Ser Ser Gly Gly Gly Ser Gly Ser Asp Ile 
                85                  90                  95      


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
            100                 105                 110         


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
        115                 120                 125             


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser 
    130                 135                 140                 


Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg 
145                 150                 155                 160 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
                165                 170                 175     


Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe 
            180                 185                 190         


Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Asp Met Pro Met Ala Asp 
        195                 200                 205             


Pro Asn Arg Phe Arg Gly Lys Asn Leu Val Phe His Ser Glu Val Gln 
    210                 215                 220                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
225                 230                 235                 240 


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
                245                 250                 255     


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
            260                 265                 270         


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
        275                 280                 285             


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
    290                 295                 300                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
305                 310                 315                 320 


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
                325                 330                 335     


Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly 
            340                 345                 350         


Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val Ala Val Tyr 
        355                 360                 365             


Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro Tyr Thr Ser 
    370                 375                 380                 


Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala Thr Gln Pro 
385                 390                 395                 400 


Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro 
                405                 410                 415     


Val Gly Thr Val Ala Pro Gln Ile Pro Pro Asn Trp His Ile Pro Ser 
            420                 425                 430         


Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr Pro Asn Asn 
        435                 440                 445             


Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu Ala Ala Leu 
    450                 455                 460                 


Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr Gln Lys Ala 
465                 470                 475                 480 


Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp Gln Pro Ser 
                485                 490                 495     


Ser His Gln Pro Leu Phe Tyr 
            500             


<210>  7
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gD as in R-VG805

<400>  7

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Ala Glu 
            20                  25                  30          


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala Ser 
        35                  40                  45              


Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His Trp 
    50                  55                  60                  


Met His Trp Val Lys Gln Arg Ala Gly Gln Gly Leu Glu Trp Ile Gly 
65                  70                  75                  80  


Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
                85                  90                  95      


Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
            100                 105                 110         


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
        115                 120                 125             


Ser Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr Trp Gly Gln 
    130                 135                 140                 


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala 
                165                 170                 175     


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
            180                 185                 190         


Ser Ser Ser Val Thr Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly Ser 
        195                 200                 205             


Ser Pro Arg Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val 
    210                 215                 220                 


Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
225                 230                 235                 240 


Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
                245                 250                 255     


Trp Ser Ser His Ile Phe Thr Phe Gly Ser Gly Thr Glu Leu Glu Ile 
            260                 265                 270         


Lys Ser Ser Ala Gly Ser Ala Ser Ser Ser Ala Ser His Ile Gln Ala 
        275                 280                 285             


Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile Thr Val Tyr 
    290                 295                 300                 


Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu Asn Ala Pro 
305                 310                 315                 320 


Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp Val Arg Lys 
                325                 330                 335     


Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly Gly Asn Cys 
            340                 345                 350         


Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser Tyr Asn Lys 
        355                 360                 365             


Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp Asn Tyr Tyr 
    370                 375                 380                 


Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe Leu Met His 
385                 390                 395                 400 


Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu Val Lys Ile 
                405                 410                 415     


Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His Arg Ala Lys 
            420                 425                 430         


Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro Ser Ala Cys 
        435                 440                 445             


Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp Ser Ile Gly 
    450                 455                 460                 


Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val Ala Val Tyr 
465                 470                 475                 480 


Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro Tyr Thr Ser 
                485                 490                 495     


Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala Thr Gln Pro 
            500                 505                 510         


Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu Glu Asp Pro 
        515                 520                 525             


Val Gly Thr Val Ala Pro Gln Ile Pro Pro Asn Trp His Ile Pro Ser 
    530                 535                 540                 


Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr Pro Asn Asn 
545                 550                 555                 560 


Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu Ala Ala Leu 
                565                 570                 575     


Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr Gln Lys Ala 
            580                 585                 590         


Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp Gln Pro Ser 
        595                 600                 605             


Ser His Gln Pro Leu Phe Tyr 
    610                 615 


<210>  8
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gD as in R-VG807

<400>  8

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala Ser Asp 
            20                  25                  30          


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
        35                  40                  45              


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val 
    50                  55                  60                  


Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
65                  70                  75                  80  


Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
                85                  90                  95      


Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
            100                 105                 110         


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr 
        115                 120                 125             


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Asp Met Pro Met Ala 
    130                 135                 140                 


Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Val Phe His Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile 
            180                 185                 190         


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg 
        195                 200                 205             


Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg 
                245                 250                 255     


Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            260                 265                 270         


Leu Val Thr Val Ser Ser Ser Ala Gly Ser Ala Ser Ser Ser Ala Ser 
        275                 280                 285             


His Ile Gln Ala Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro 
    290                 295                 300                 


Ile Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu 
305                 310                 315                 320 


Leu Asn Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu 
                325                 330                 335     


Asp Val Arg Lys Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met 
            340                 345                 350         


Gly Gly Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys 
        355                 360                 365             


Ser Tyr Asn Lys Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg 
    370                 375                 380                 


Trp Asn Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly 
385                 390                 395                 400 


Phe Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg 
                405                 410                 415     


Leu Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu 
            420                 425                 430         


His Arg Ala Lys Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro 
        435                 440                 445             


Pro Ser Ala Cys Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val 
    450                 455                 460                 


Asp Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr 
465                 470                 475                 480 


Val Ala Val Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala 
                485                 490                 495     


Pro Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn 
            500                 505                 510         


Ala Thr Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu 
        515                 520                 525             


Leu Glu Asp Pro Val Gly Thr Val Ala Pro Gln Ile Pro Pro Asn Trp 
    530                 535                 540                 


His Ile Pro Ser Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala 
545                 550                 555                 560 


Thr Pro Asn Asn Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu 
                565                 570                 575     


Leu Ala Ala Leu Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg 
            580                 585                 590         


Thr Gln Lys Ala Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp 
        595                 600                 605             


Asp Gln Pro Ser Ser His Gln Pro Leu Phe Tyr 
    610                 615                 


<210>  9
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gD as in R-VG809

<400>  9

Met Gly Gly Ala Ala Ala Arg Leu Gly Ala Val Ile Leu Phe Val Val 
1               5                   10                  15      


Ile Val Gly Leu His Gly Val Arg Gly Lys Tyr Ala Leu Ala His Ile 
            20                  25                  30          


Gln Ala Gly Leu Pro Asp Pro Phe Gln Pro Pro Ser Leu Pro Ile Thr 
        35                  40                  45              


Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu Asn 
    50                  55                  60                  


Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Glu Asp Val 
65                  70                  75                  80  


Arg Lys Gln Pro Tyr Asn Leu Thr Ile Ala Trp Phe Arg Met Gly Gly 
                85                  90                  95      


Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Ser Tyr 
            100                 105                 110         


Asn Lys Ser Leu Gly Ala Cys Pro Ile Arg Thr Gln Pro Arg Trp Asn 
        115                 120                 125             


Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe Leu 
    130                 135                 140                 


Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu Val 
145                 150                 155                 160 


Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His Arg 
                165                 170                 175     


Ala Lys Gly Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro Ser 
            180                 185                 190         


Ala Cys Leu Ser Pro Gln Ala Tyr Gln Gln Gly Val Thr Val Asp Ser 
        195                 200                 205             


Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val Ala 
    210                 215                 220                 


Val Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Ala Pro Tyr 
225                 230                 235                 240 


Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Glu Thr Pro Asn Ala Thr 
                245                 250                 255     


Gln Pro Glu Leu Ala Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu Glu 
            260                 265                 270         


Asp Pro Val Gly Thr Val Ala Pro Gln Ile Pro Pro Asn Trp His Ile 
        275                 280                 285             


Pro Ser Ile Gln Asp Ala Ala Thr Pro Tyr His Pro Pro Ala Thr Pro 
    290                 295                 300                 


Asn Asn Met Gly Leu Ile Ala Gly Ala Val Gly Gly Ser Leu Leu Ala 
305                 310                 315                 320 


Ala Leu Val Ile Cys Gly Ile Val Tyr Trp Met Arg Arg Arg Thr Gln 
                325                 330                 335     


Lys Ala Pro Lys Arg Ile Arg Leu Pro His Ile Arg Glu Asp Asp Gln 
            340                 345                 350         


Pro Ser Ser His Gln Pro Leu Phe Tyr 
        355                 360     


<210>  10
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gH6_galK_f

<400>  10
atgcggtcca tgcccaggcc atccaaaaac catgggtctg tctgctcagt cctgttgaca       60

attaatcatc ggca                                                         74


<210>  11
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gH5_galK_r

<400>  11
tcgtgggggt tattattttg ggcgttgcgt ggggtcaggt ccacgactgg tcagcactgt       60

cctgctcctt                                                              70


<210>  12
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSG-ScFvHER2-SG trastuzumab scFv cassette bracketed by Ser-Gly 
       linkers

<400>  12
catagtagtg gcggtggctc tggatccgat atccagatga cccagtcccc gagctccctg       60

tccgcctctg tgggcgatag ggtcaccatc acctgccgtg ccagtcagga tgtgaatact      120

gctgtagcct ggtatcaaca gaaaccagga aaagctccga agcttctgat ttactcggca      180

tccttcctct actctggagt cccttctcgc ttctctggta gccgttccgg gacggatttc      240

actctgacca tcagcagtct gcagccggaa gacttcgcaa cttattactg tcagcaacat      300

tatactactc ctcccacgtt cggacagggt accaaggtgg agatcaaatc ggatatgccg      360

atggctgatc cgaaccgttt ccgcggtaag aacctggttt ttcattctga ggttcagctg      420

gtggagtctg gcggtggcct ggtgcagcca gggggctcac tccgtttgtc ctgtgcagct      480

tctggcttca acattaaaga cacctatata cactgggtgc gtcaggcccc gggtaagggc      540

ctggaatggg ttgcaaggat ttatcctacg aatggttata ctagatatgc cgatagcgtc      600

aagggccgtt tcactataag cgcagacaca tccaaaaaca cagcctacct acaaatgaac      660

agcttaagag ctgaggacac tgccgtctat tattgtagcc gctggggagg ggacggcttc      720

tatgctatgg actactgggg tcaaggaaca ctagtcaccg tctcctcgag tggcggtggc      780

tctggttccg gtggatccgg t                                                801


<210>  13
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gH23_8SG_scFv4D5_f

<400>  13
tcgtgggggt tattattttg ggcgttgcgt ggggtcaggt ccacgactgg catagtagtg       60

gcggtggctc tggatccg                                                     78


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer scFv4D5_358_r

<400>  14
ggaaacggtt cggatcagcc atcgg                                             25


<210>  15
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gH24_12SG_scFv4D5r

<400>  15
atgcggtcca tgcccaggcc atccaaaaac catgggtctg tctgctcagt accggatcca       60

ccggaaccag agcc                                                         74


<210>  16
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer scFv4D5_315_f

<400>  16
ggagatcaaa tcggatatgc cgatgg                                            26


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  17

His Ser Ser Gly Gly Gly Ser Gly 
1               5               


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  18

Ser Ser Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly 
1               5                   10          


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  19

Ser Asp Met Pro Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu 
1               5                   10                  15      


Val Phe His Ser 
            20  


<210>  20
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer UL37/38_galK_f

<400>  20
ccgcaggcgt tgcgagtacc ccgcgtcttc gcggggtgtt atacggccac cctgttgaca       60

attaatcatc ggca                                                         74


<210>  21
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer UL37/38_galK_r

<400>  21
tccggacaat cccccgggcc tgggtccgcg aacgggatgc cgggacttaa tcagcactgt       60

cctgctcctt                                                              70


<210>  22
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer UL37/38_CMV_mcherry_f

<400>  22
ccgcaggcgt tgcgagtacc ccgcgtcttc gcggggtgtt atacggccac cgatgtacgg       60

gccagatata cg                                                           72


<210>  23
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer UL37/38_pA_mcherry_1958_r

<400>  23
tccggacaat cccccgggcc tgggtccgcg aacgggatgc cgggacttaa ccatagagcc       60

caccgcatcc                                                              70


<210>  24
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gH29_galK_f

<400>  24
cgcggtggtt tttgggggtc gggggtgttt ggcagccaca gacgcccggt cctgttgaca       60

attaatcatc ggca                                                         74


<210>  25
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gH5_galK_r

<400>  25
tcgtgggggt tattattttg ggcgttgcgt ggggtcaggt ccacgactgg tcagcactgt       60

cctgctcctt                                                              70


<210>  26
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gH48_12SG_scFv4D5_r

<400>  26
ccgcgcggtg gtttttgggg gtcgggggtg tttggcagcc acagacgccc accggatcca       60

ccggaaccag agcc                                                         74


<210>  27
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer scFv4D5_315_f

<400>  27
ggagatcaaa tcggatatgc cgatgg                                            26


<210>  28
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer galK_129_f

<400>  28
acaatctctg tttgccaacg catttgg                                           27


<210>  29
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer galK_417_r

<400>  29
cattgccgct gatcaccatg tccacgc                                           27


<210>  30
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gD5_galK_f

<400>  30
ttgtcgtcat agtgggcctc catggggtcc gcggcaaata tgccttggcg cctgttgaca       60

attaatcatc ggca                                                         74


<210>  31
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gD39_galK_r

<400>  31
atcgggaggc tggggggctg gaacgggtcc ggtaggcccg cctggatgtg tcagcactgt       60

cctgctcctt                                                              70


<210>  32
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide gD_aa5_39_f_r

<400>  32
ttgtcgtcat agtgggcctc catggggtcc gcggcaaata tgccttggcg cacatccagg       60

cgggcctacc ggacccgttc cagcccccca gcctcccgat                            100


<210>  33
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gD5_galK_f

<400>  33
ttgtcgtcat agtgggcctc catggggtcc gcggcaaata tgccttggcg cctgttgaca       60

attaatcatc ggca                                                         74


<210>  34
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gD39_galK_r

<400>  34
atcgggaggc tggggggctg gaacgggtcc ggtaggcccg cctggatgtg tcagcactgt       60

cctgctcctt                                                              70


<210>  35
<211>  73
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer BAC_LM611_f

<400>  35
ttgtcgtcat agtgggcctc catggggtcc gcggcaaata tgccttggcg gccgaggtgc       60

aactgcagca gtc                                                          73


<210>  36
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gD39_11SAG_EGFR_r

<400>  36
atcgggaggc tggggggctg gaacgggtcc ggtaggcccg cctggatgtg acttgcacta       60

gatgaagcac ttcctgcgga agatttgatc tcgagttctg tccccg                     106


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  37

Ser Ser Ala Gly Ser Ala Ser Ser Ser Ala Ser 
1               5                   10      


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  38

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  39
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gD5_galK_f

<400>  39
ttgtcgtcat agtgggcctc catggggtcc gcggcaaata tgccttggcg cctgttgaca       60

attaatcatc ggca                                                         74


<210>  40
<211>  70
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gD39_galK_r

<400>  40
atcgggaggc tggggggctg gaacgggtcc ggtaggcccg cctggatgtg tcagcactgt       60

cctgctcctt                                                              70


<210>  41
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gD5_scFvHER2_f

<400>  41
ttgtcgtcat agtgggcctc catggggtcc gcggcaaata tgccttggcg tccgatatcc       60

agatgaccca gtccc                                                        75


<210>  42
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer gD39_11SAG_HER2_r

<400>  42
atcgggaggc tggggggctg gaacgggtcc ggtaggcccg cctggatgtg acttgcacta       60

gatgaagcac ttcctgcgga agaggagacg gtgactagtg ttccttgacc                 110


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  43

Ser Ser Ala Gly Ser Ala Ser Ser Ser Ala Ser 
1               5                   10      


<210>  44
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  44

Ser Asp Met Pro Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu 
1               5                   10                  15      


Val Phe His Ser 
            20  


