                         б

<110>  廪ѧ
       ޼Ƽչ޹˾
 
<120>  һ鵰ҩķ

<130>  0120-PCT

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


<210>  2
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  2

Met Gly Gly Ser His His His His His His Ser His Arg Asp Phe Gln 
1               5                   10                  15      


Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser Gly Gly Met 
            20                  25                  30          


Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln Ala Arg Ala 
        35                  40                  45              


Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser Arg Leu Gln 
    50                  55                  60                  


Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala Val Pro Ile 
65                  70                  75                  80  


Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu Ala Leu Phe 
                85                  90                  95      


Ser Gly Ser Glu Gly Pro Leu Lys Pro Gly Ala Arg Ile Phe Ser Phe 
            100                 105                 110         


Asp Gly Lys Asp Val Leu Arg His Pro Thr Trp Pro Gln Lys Ser Val 
        115                 120                 125             


Trp His Gly Ser Asp Pro Asn Gly Arg Arg Leu Thr Glu Ser Tyr Cys 
    130                 135                 140                 


Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala Thr Gly Gln Ala Ser Ser 
145                 150                 155                 160 


Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala Ser Cys His His 
                165                 170                 175     


Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser Phe Met Thr Ala Ser Lys 
            180                 185                 190         


<210>  3
<211>  180
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  3

Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser 
1               5                   10                  15      


Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln 
            20                  25                  30          


Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser 
        35                  40                  45              


Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala 
    50                  55                  60                  


Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu 
65                  70                  75                  80  


Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro Gly Ala Arg 
                85                  90                  95      


Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr Trp Pro 
            100                 105                 110         


Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg Leu Thr 
        115                 120                 125             


Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala Thr Gly 
    130                 135                 140                 


Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala 
145                 150                 155                 160 


Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser Phe Met 
                165                 170                 175     


Thr Ala Ser Lys 
            180 


<210>  4
<211>  171
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  4

Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser 
1               5                   10                  15      


Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln 
            20                  25                  30          


Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser 
        35                  40                  45              


Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala 
    50                  55                  60                  


Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu 
65                  70                  75                  80  


Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Ser Pro Gly Ala Arg 
                85                  90                  95      


Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr Trp Pro 
            100                 105                 110         


Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg Leu Thr 
        115                 120                 125             


Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala Thr Gly 
    130                 135                 140                 


Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala 
145                 150                 155                 160 


Ser Cys His His Ala Tyr Ile Val Leu Cys Ile 
                165                 170     


<210>  5
<211>  171
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  5

Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser 
1               5                   10                  15      


Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln 
            20                  25                  30          


Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser 
        35                  40                  45              


Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala 
    50                  55                  60                  


Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu 
65                  70                  75                  80  


Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Thr Pro Gly Ala Arg 
                85                  90                  95      


Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr Trp Pro 
            100                 105                 110         


Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg Leu Thr 
        115                 120                 125             


Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala Thr Gly 
    130                 135                 140                 


Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala 
145                 150                 155                 160 


Ser Cys His His Ala Tyr Ile Val Leu Cys Ile 
                165                 170     


<210>  6
<211>  171
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  6

Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser 
1               5                   10                  15      


Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln 
            20                  25                  30          


Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser 
        35                  40                  45              


Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala 
    50                  55                  60                  


Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu 
65                  70                  75                  80  


Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro Gly Ala Arg 
                85                  90                  95      


Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr Trp Pro 
            100                 105                 110         


Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg Leu Thr 
        115                 120                 125             


Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala Thr Gly 
    130                 135                 140                 


Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala 
145                 150                 155                 160 


Ser Cys His His Ala Tyr Ile Val Leu Cys Ile 
                165                 170     


<210>  7
<211>  177
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  7

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr 
                85                  90                  95      


Pro Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His 
            100                 105                 110         


Pro Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly 
        115                 120                 125             


Arg Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro 
    130                 135                 140                 


Ser Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly 
145                 150                 155                 160 


Gln Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu 
                165                 170                 175     


Asn 
    


<210>  8
<211>  180
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  8

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr 
                85                  90                  95      


Pro Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His 
            100                 105                 110         


Pro Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly 
        115                 120                 125             


Arg Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro 
    130                 135                 140                 


Ser Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly 
145                 150                 155                 160 


Gln Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu 
                165                 170                 175     


Asn Ser Phe Met 
            180 


<210>  9
<211>  176
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  9

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


<210>  10
<211>  175
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  10

His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro 
1               5                   10                  15      


Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe 
            20                  25                  30          


Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu 
        35                  40                  45              


Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg 
    50                  55                  60                  


Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser 
65                  70                  75                  80  


Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro Gly 
                85                  90                  95      


Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr 
            100                 105                 110         


Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg 
        115                 120                 125             


Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala 
    130                 135                 140                 


Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser 
145                 150                 155                 160 


Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175 


<210>  11
<211>  178
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  11

His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro 
1               5                   10                  15      


Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe 
            20                  25                  30          


Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu 
        35                  40                  45              


Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg 
    50                  55                  60                  


Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser 
65                  70                  75                  80  


Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro Gly 
                85                  90                  95      


Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr 
            100                 105                 110         


Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg 
        115                 120                 125             


Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala 
    130                 135                 140                 


Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser 
145                 150                 155                 160 


Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser 
                165                 170                 175     


Phe Met 
        


<210>  12
<211>  181
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  12

His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro 
1               5                   10                  15      


Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe 
            20                  25                  30          


Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu 
        35                  40                  45              


Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg 
    50                  55                  60                  


Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser 
65                  70                  75                  80  


Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro Gly 
                85                  90                  95      


Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr 
            100                 105                 110         


Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg 
        115                 120                 125             


Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala 
    130                 135                 140                 


Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser 
145                 150                 155                 160 


Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser 
                165                 170                 175     


Phe Met Thr Ala Ser 
            180     


<210>  13
<211>  182
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  13

Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser 
1               5                   10                  15      


Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys 
            20                  25                  30          


Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe 
        35                  40                  45              


Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp 
    50                  55                  60                  


Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro 
65                  70                  75                  80  


Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser 
            180         


<210>  14
<211>  176
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  14

Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser 
1               5                   10                  15      


Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys 
            20                  25                  30          


Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe 
        35                  40                  45              


Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp 
    50                  55                  60                  


Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro 
65                  70                  75                  80  


Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


<210>  15
<211>  179
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  15

Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser 
1               5                   10                  15      


Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys 
            20                  25                  30          


Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe 
        35                  40                  45              


Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp 
    50                  55                  60                  


Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro 
65                  70                  75                  80  


Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met 
            


<210>  16
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  16

Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser 
1               5                   10                  15      


Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys 
            20                  25                  30          


Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe 
        35                  40                  45              


Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp 
    50                  55                  60                  


Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro 
65                  70                  75                  80  


Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


<210>  17
<211>  182
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  17

His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro 
1               5                   10                  15      


Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe 
            20                  25                  30          


Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu 
        35                  40                  45              


Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg 
    50                  55                  60                  


Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser 
65                  70                  75                  80  


Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro Gly 
                85                  90                  95      


Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr 
            100                 105                 110         


Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg 
        115                 120                 125             


Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala 
    130                 135                 140                 


Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser 
145                 150                 155                 160 


Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser 
                165                 170                 175     


Phe Met Thr Ala Ser Lys 
            180         


<210>  18
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  18

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Gly Glu Ser Gly Ala Gly Lys Thr Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


<210>  19
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  19

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr 
                85                  90                  95      


Pro Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


<210>  20
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  20

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


<210>  21
<211>  184
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  21

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr 
                85                  90                  95      


Gly Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His 
            100                 105                 110         


Pro Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly 
        115                 120                 125             


Arg Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro 
    130                 135                 140                 


Ser Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly 
145                 150                 155                 160 


Gln Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu 
                165                 170                 175     


Asn Ser Phe Met Thr Ala Ser Lys 
            180                 


<210>  22
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  22

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Ala Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


<210>  23
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  23

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Glu Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


<210>  24
<211>  184
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  24

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr 
                85                  90                  95      


Pro Gly Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His 
            100                 105                 110         


Pro Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly 
        115                 120                 125             


Arg Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro 
    130                 135                 140                 


Ser Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly 
145                 150                 155                 160 


Gln Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu 
                165                 170                 175     


Asn Ser Phe Met Thr Ala Ser Lys 
            180                 


<210>  25
<211>  179
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  25

Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu 
1               5                   10                  15      


Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln 
            20                  25                  30          


Gln Ala Arg Gln Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser 
        35                  40                  45              


Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala 
    50                  55                  60                  


Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp 
65                  70                  75                  80  


Glu Ala Leu Phe Ser Ser Glu Gly Pro Leu Lys Pro Gly Ala Arg Ile 
                85                  90                  95      


Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr Trp Pro Gln 
            100                 105                 110         


Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg Leu Thr Glu 
        115                 120                 125             


Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala Thr Gly Gln 
    130                 135                 140                 


Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala Ser 
145                 150                 155                 160 


Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser Phe Met Thr 
                165                 170                 175     


Ala Ser Lys 
            


<210>  26
<211>  180
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  26

Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu 
1               5                   10                  15      


Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln 
            20                  25                  30          


Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser 
        35                  40                  45              


Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Gly 
    50                  55                  60                  


Ser Val Pro Ile Val Asn Leu Lys Asp Glu Val Leu Ser Pro Ser Trp 
65                  70                  75                  80  


Asp Ser Leu Phe Ser Gly Ser Gln Gly Gln Leu Gln Pro Gly Ala Arg 
                85                  90                  95      


Ile Phe Ser Phe Asp Gly Arg Asp Ile Leu Gln Asp Ser Ala Trp Pro 
            100                 105                 110         


Gln Lys Ser Val Trp His Gly Ser Asp Ala Lys Gly Arg Arg Leu Pro 
        115                 120                 125             


Glu Ser Tyr Cys Glu Ala Trp Arg Thr Asp Glu Arg Gly Thr Ser Gly 
    130                 135                 140                 


Gln Ala Ser Ser Leu Leu Ser Gly Arg Leu Leu Glu Gln Lys Ala Ala 
145                 150                 155                 160 


Ser Cys His Asn Ser Tyr Ile Val Leu Cys Ile Glu Asn Ser Phe Met 
                165                 170                 175     


Thr Ala Ser Lys 
            180 


<210>  27
<211>  184
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  27

His Val His Gln Asp Phe Gln Pro Ala Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Thr Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Gln Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Thr Ala Val Pro Ile Val Asn Leu Arg Asp Glu Val Leu Phe 
65                  70                  75                  80  


Ser Asn Trp Glu Ala Leu Phe Thr Gly Ser Glu Ala Pro Leu Arg Ala 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Arg Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Ala Gly Arg Leu Leu Glu Gln 
145                 150                 155                 160 


Lys Ala Ala Gly Cys His Asn Ala Phe Ile Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ser Ser Ser Lys 
            180                 


<210>  28
<211>  185
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  28

His Thr His Gln Asp Phe His Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Thr Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ser Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Glu Ser Gly Ala Gly Lys Thr 
                85                  90                  95      


Gly Gly Ala Arg Ile Phe Ser Phe Asp Gly Arg Asp Val Leu Arg His 
            100                 105                 110         


Pro Ala Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Ser Gly 
        115                 120                 125             


Arg Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Asp Ser Arg 
    130                 135                 140                 


Ala Ala Thr Gly Gln Ala Ser Ser Leu Leu Ala Gly Arg Leu Leu Glu 
145                 150                 155                 160 


Gln Lys Ala Ala Gly Cys His Asn Ala Phe Ile Val Leu Cys Ile Glu 
                165                 170                 175     


Asn Ser Phe Met Thr Ser Ser Ser Lys 
            180                 185 


<210>  29
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  29

His Ser His Arg Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Ser Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Arg Asp Val Leu Arg His Pro 
            100                 105                 110         


Thr Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Ser Gly His 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Asp Ser Arg Ala 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln 
145                 150                 155                 160 


Ser Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Ala Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ser Lys 
            180             


<210>  30
<211>  179
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  30

Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser 
1               5                   10                  15      


Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln 
            20                  25                  30          


Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser 
        35                  40                  45              


Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala 
    50                  55                  60                  


Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu 
65                  70                  75                  80  


Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Arg Pro Gly Ala Arg Ile 
                85                  90                  95      


Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr Leu Pro Gln 
            100                 105                 110         


Lys Ser Val Trp His Gly Ser Asp Pro Ser Gly Arg Arg Leu Thr Glu 
        115                 120                 125             


Ser Tyr Cys Glu Thr Trp Arg Thr Asp Ser Arg Ala Ala Thr Gly Gln 
    130                 135                 140                 


Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala Ser 
145                 150                 155                 160 


Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser Phe Met Thr 
                165                 170                 175     


Ala Ser Lys 
            


<210>  31
<211>  180
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  31

Asp Phe Gln Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser 
1               5                   10                  15      


Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln 
            20                  25                  30          


Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser 
        35                  40                  45              


Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala 
    50                  55                  60                  


Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu 
65                  70                  75                  80  


Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Arg Pro Gly Ala Arg Ile 
                85                  90                  95      


Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr Leu Pro Gln 
            100                 105                 110         


Lys Ser Val Trp His Gly Ser Asp Pro Ser Gly Arg Arg Leu Thr Glu 
        115                 120                 125             


Ser Tyr Cys Glu Thr Trp Arg Thr Asp Ser Arg Ala Ala Thr Gly Gln 
    130                 135                 140                 


Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala Ser 
145                 150                 155                 160 


Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser Phe Met Thr 
                165                 170                 175     


Ala Ser Lys Lys 
            180 


<210>  32
<211>  184
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  32

His Thr His Gln Asp Phe His Pro Val Leu His Leu Val Ala Leu Asn 
1               5                   10                  15      


Thr Pro Leu Ser Gly Gly Met Arg Gly Ile Arg Gly Ala Asp Phe Gln 
            20                  25                  30          


Cys Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala 
        35                  40                  45              


Phe Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala 
    50                  55                  60                  


Asp Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Leu Leu Phe 
65                  70                  75                  80  


Pro Ser Trp Glu Ala Leu Phe Ser Gly Ser Glu Gly Pro Leu Lys Pro 
                85                  90                  95      


Gly Ala Arg Ile Phe Ser Phe Asp Gly Arg Asp Ile Leu Gln Asp Ser 
            100                 105                 110         


Ala Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg 
        115                 120                 125             


Arg Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser 
    130                 135                 140                 


Ala Thr Gly Gln Ala Ser Ser Leu Ser Ser Gly Lys Leu Leu Glu Gln 
145                 150                 155                 160 


Ser Val Ser Ser Cys Gln His Ala Phe Val Val Leu Cys Ile Glu Asn 
                165                 170                 175     


Ser Phe Met Thr Ala Ala Lys Lys 
            180                 


<210>  33
<211>  183
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  33

Thr Pro Thr Trp Tyr Pro Arg Met Leu Arg Val Ala Ala Leu Asn Glu 
1               5                   10                  15      


Pro Ser Thr Gly Asp Leu Gln Gly Ile Arg Gly Ala Asp Phe Gln Cys 
            20                  25                  30          


Phe Gln Gln Ala Arg Ala Val Gly Leu Ser Gly Thr Phe Arg Ala Phe 
        35                  40                  45              


Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp 
    50                  55                  60                  


Arg Ala Ala Val Pro Ile Val Asn Leu Lys Asp Glu Val Leu Ser Pro 
65                  70                  75                  80  


Ser Trp Asp Ser Leu Phe Ser Gly Ser Gln Gly Gln Leu Gln Pro Gly 
                85                  90                  95      


Ala Arg Ile Phe Ser Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr 
            100                 105                 110         


Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Ser Gly Arg Arg 
        115                 120                 125             


Leu Met Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Thr Thr Gly Ala 
    130                 135                 140                 


Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser 
145                 150                 155                 160 


Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser 
                165                 170                 175     


Phe Met Thr Asn Asn Arg Lys 
            180             


<210>  34
<211>  182
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  34

His Thr His Thr Ser Gly Pro Gly Leu His Leu Ile Ala Leu Asn Ser 
1               5                   10                  15      


Pro Gln Val Gly Asn Met Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys 
            20                  25                  30          


Phe Gln Gln Ala Arg Ala Val Gly Leu Ala Gly Thr Phe Arg Ala Phe 
        35                  40                  45              


Leu Ser Ser Arg Leu Gln Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp 
    50                  55                  60                  


Arg Ser Ser Val Pro Ile Val Asn Leu Lys Asp Glu Val Leu Ser Pro 
65                  70                  75                  80  


Ser Trp Asp Ser Leu Phe Ser Val Ser Gln Gly Gln Leu Gln Pro Gly 
                85                  90                  95      


Ala Arg Ile Phe Ser Phe Asp Gly Arg Asp Ile Leu Gln Asp Ser Ala 
            100                 105                 110         


Trp Pro Gln Lys Ser Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg 
        115                 120                 125             


Leu Thr Glu Ser Tyr Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala 
    130                 135                 140                 


Thr Gly Gln Ala Ser Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser 
145                 150                 155                 160 


Ala Ala Ser Cys His His Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser 
                165                 170                 175     


Phe Met Thr Ala Ser Lys 
            180         


<210>  35
<211>  31
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  35
ggaattccat atgcacagcc accgcgactt c                                      31


<210>  36
<211>  34
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  36
ccgctcgagt tacttggagg cagtcatgaa gctg                                   34


<210>  37
<211>  193
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  37

Met Gly Gly Ser His His His His His His Ser His Arg Asp Phe Gln 
1               5                   10                  15      


Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser Gly Gly Met 
            20                  25                  30          


Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln Ala Arg Ala 
        35                  40                  45              


Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser Arg Leu Gln 
    50                  55                  60                  


Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala Val Pro Ile 
65                  70                  75                  80  


Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu Ala Leu Phe 
                85                  90                  95      


Ser Gly Glu Ser Gly Ala Gly Lys Thr Pro Gly Ala Arg Ile Phe Ser 
            100                 105                 110         


Phe Asp Gly Lys Asp Val Leu Arg His Pro Thr Trp Pro Gln Lys Ser 
        115                 120                 125             


Val Trp His Gly Ser Asp Pro Asn Gly Arg Arg Leu Thr Glu Ser Tyr 
    130                 135                 140                 


Cys Glu Thr Trp Arg Thr Glu Ala Pro Ser Ala Thr Gly Gln Ala Ser 
145                 150                 155                 160 


Ser Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala Ser Cys His 
                165                 170                 175     


His Ala Tyr Ile Val Leu Cys Ile Glu Asn Ser Phe Met Thr Ala Ser 
            180                 185                 190         


Lys 
    


<210>  38
<211>  192
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  38

Met Gly Gly Ser His His His His His His Ser His Arg Asp Phe Gln 
1               5                   10                  15      


Pro Val Leu His Leu Val Ala Leu Asn Ser Pro Leu Ser Gly Gly Met 
            20                  25                  30          


Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln Ala Arg Ala 
        35                  40                  45              


Val Gly Leu Ala Gly Thr Phe Arg Ala Phe Leu Ser Ser Arg Leu Gln 
    50                  55                  60                  


Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala Val Pro Ile 
65                  70                  75                  80  


Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu Ala Leu Phe 
                85                  90                  95      


Ser Gly Ser Glu Gly Pro Leu Lys Pro Gly Ala Arg Ile Phe Ser Phe 
            100                 105                 110         


Asp Gly Arg Asp Val Leu Arg His Pro Thr Trp Pro Gln Lys Ser Val 
        115                 120                 125             


Trp His Gly Ser Asp Pro Ser Gly His Arg Leu Thr Glu Ser Tyr Cys 
    130                 135                 140                 


Glu Thr Trp Arg Thr Asp Ser Arg Ala Ala Thr Gly Gln Ala Ser Ser 
145                 150                 155                 160 


Leu Leu Gly Gly Arg Leu Leu Gly Gln Ser Ala Ala Ser Cys His His 
                165                 170                 175     


Ala Tyr Ile Val Leu Cys Ile Ala Asn Ser Phe Met Thr Ala Ser Lys 
            180                 185                 190         


<210>  39
<211>  194
<212>  PRT
<213>  ˹

<220>
<223>  ͻ

<400>  39

Met Gly Gly Ser His His His His His His Thr His Gln Asp Phe His 
1               5                   10                  15      


Pro Val Leu His Leu Val Ala Leu Asn Thr Pro Leu Ser Gly Gly Met 
            20                  25                  30          


Arg Gly Ile Arg Gly Ala Asp Phe Gln Cys Phe Gln Gln Ala Arg Ala 
        35                  40                  45              


Val Gly Leu Ser Gly Thr Phe Arg Ala Phe Leu Ser Ser Arg Leu Gln 
    50                  55                  60                  


Asp Leu Tyr Ser Ile Val Arg Arg Ala Asp Arg Ala Ala Val Pro Ile 
65                  70                  75                  80  


Val Asn Leu Lys Asp Glu Leu Leu Phe Pro Ser Trp Glu Ala Leu Phe 
                85                  90                  95      


Ser Gly Glu Ser Gly Ala Gly Lys Thr Gly Gly Ala Arg Ile Phe Ser 
            100                 105                 110         


Phe Asp Gly Arg Asp Val Leu Arg His Pro Ala Trp Pro Gln Lys Ser 
        115                 120                 125             


Val Trp His Gly Ser Asp Pro Ser Gly Arg Arg Leu Thr Glu Ser Tyr 
    130                 135                 140                 


Cys Glu Thr Trp Arg Thr Asp Ser Arg Ala Ala Thr Gly Gln Ala Ser 
145                 150                 155                 160 


Ser Leu Leu Ala Gly Arg Leu Leu Glu Gln Lys Ala Ala Gly Cys His 
                165                 170                 175     


Asn Ala Phe Ile Val Leu Cys Ile Glu Asn Ser Phe Met Thr Ser Ser 
            180                 185                 190         


Ser Lys 
        


