                         SEQUENCE LISTING

<110>  FENG, Hanping
 
<120>  TETRA-SPECIFIC, OCTAMERIC BINDING AGENTS AND ANTIBODIES AGAINST 
       CLOSTRIDIUM DIFFICILE TOXIN A AND TOXIN B

<130>  2016-0045A

<150>  US 62/113,046
<151>  2015-02-06

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VHH peptide monomer 5D

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp 
            100                 105                 110         


Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser 
        115                 120                 125         


<210>  2
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VHH peptide monomer 5D

<400>  2
caggtgcaac tggttgaatc tgggggaggc ttggtacaac ctgggggatc cctgagactc       60

tcttgcgagg cctccggatt caccttggac tactatggca tcggctggtt ccgccagccc      120

ccagggaagg agcgggaggc cgtttcatac attagtgcca gtgcccggac catactgtac      180

gcagactctg tgaagggacg ctttaccatc tctagggaca atgccaaaaa tgctgtgtac      240

ctgcaaatga acagcctcaa gcgggaggat accgcagtgt actactgcgc gagacggcgc      300

ttctccgctt ctagcgtgaa tagatggctg gccgacgact acgacgtgtg gggacggggc      360

acacaggtgg ctgtctcgag c                                                381


<210>  3
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VHH peptide monomer E3

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu 
            20                  25                  30          


Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val 
        35                  40                  45              


Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys 
                85                  90                  95      


Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val Thr Val Ser Ser 
            100                 105                 110     


<210>  4
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VHH peptide monomer E3

<400>  4
caagttcagc tggtcgaatc cgggggcgga ctggtccaga cagggggctc cctgaggctc       60

tcctgtgcat cttccggaag catcgccggc ttcgagaccg tgacctggtc tcgccaggct      120

cccgggaagt ctctgcagtg ggtcgcttcc atgactaaga ctaacaacga gatctactct      180

gactcagtga aaggccgctt catcatttct agagataacg ctaaaaacac agtgtatctg      240

cagatgaata gtctcaaacc tgaagacaca ggcgtgtatt tctgtaaggg tcctgagctg      300

aggggccagg gcatccaggt aacagtctcg agt                                   333


<210>  5
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VHH peptide monomer AA6

<400>  5

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  6
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VHH peptide monomer AA6

<400>  6
caactgcagc tggtagagac agggggcggc ttagttcagc ctggagggtc tctcagactg       60

tcatgcgctg cctctggctt taccttcagt gactacgtga tgacatgggt ccgccaagct      120

ccagggaagg ggcctgagtg gatcgctact attaatacag atggcagcac aatgcgggac      180

gactccacaa aggggcggtt caccatttcc agagacaacg ccaagaatac tctgtacctt      240

cagatgacca gtctgaaacc cgaggacact gctctgtact attgtgcaag aggccgggtg      300

atctctgctt ccgctatcag aggcgcagta aggggccctg gaacacaagt aactgtctcg      360

agc                                                                    363


<210>  7
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VHH peptide monomer AH3

<400>  7

Gln Val Gln Leu Val Glu Thr Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser Ser 
            20                  25                  30          


Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
        35                  40                  45              


Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr Gly 
            100                 105                 110         


Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  8
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VHH peptide monomer AH3

<400>  8
caggtacagc tggtggagac gggggggctg gtacaaccag gcgggtcact gaggctttcc       60

tgtgccgcat ctgggttcac actggattat tcgtccatag ggtggtttcg gcaggctcct      120

ggcaaagagc gtgagggggt ctcatgtatt agtagtagtg gtgatagcac aaagtacgcc      180

gattccgtaa agggccggtt tacaacctcc agggataatg ctaagaacac cgtatatctc      240

cagatgaact ctctgaagcc cgacgatacg gccgtatatt actgtgcggc tttcagggcg      300

actatgtgcg gcgtgttccc tctgagccct tacggcaagg acgactgggg caaggggacc      360

ctggtgaccg tctcgagt                                                    378


<210>  9
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Codon-optimized flexible linker 1

<400>  9

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  10
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized flexible linker 1

<400>  10
ggcggtggag ggtctggtgg gggaggctca gggggtggag gcagc                       45


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Codon-optimized flexible linker 2

<400>  11

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  12
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized flexible linker 2

<400>  12
ggtggcggaa gcggaggggg cagcgggggt gggagcggtg ggggcagc                    48


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Codon-optimized flexible linker 3

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  14
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized flexible linker 3

<400>  14
gggggaggcg gttcaggcgg tgggggatct ggcgggggtg gatcc                       45


<210>  15
<211>  269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AH3-5D heterodimer

<400>  15

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr 
            100                 105                 110         


Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Gly Ile 
                165                 170                 175     


Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val Ser Tyr 
            180                 185                 190         


Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp Asp Tyr 
                245                 250                 255     


Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser 
            260                 265                 


<210>  16
<211>  807
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AH3-5D heterodimer

<400>  16
caggtacagc tggtggagac ggggggaggg ctggtacaac caggcgggtc actgaggctt       60

tcctgtgccg catctgggtt cacactggat tattcgtcca tagggtggtt tcggcaggct      120

cctggcaaag agcgtgaggg ggtctcatgt attagtagta gtggtgatag cacaaagtac      180

gccgattccg taaagggccg gtttacaacc tccagggata atgctaagaa caccgtatat      240

ctccagatga actctctgaa gcccgacgat acggccgtat attactgtgc ggctttcagg      300

gcgactatgt gcggcgtgtt ccctctgagc ccttacggca aggacgactg gggcaagggg      360

accctggtga ccgtatcctc aggcggtgga gggtctggtg ggggaggctc agggggtgga      420

ggcagccagg tgcaactggt tgaatctggg ggaggcttgg tacaacctgg gggatccctg      480

agactctctt gcgaggcctc cggattcacc ttggactact atggcatcgg ctggttccgc      540

cagcccccag ggaaggagcg ggaggccgtt tcatacatta gtgccagtgc ccggaccata      600

ctgtacgcag actctgtgaa gggacgcttt accatctcta gggacaatgc caaaaatgct      660

gtgtacctgc aaatgaacag cctcaagcgg gaggataccg cagtgtacta ctgcgcgaga      720

cggcgcttct ccgcttctag cgtgaataga tggctggccg acgactacga cgtgtgggga      780

cggggcacac aggtggctgt ctcgagc                                          807


<210>  17
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA6-E3 heterodimer

<400>  17

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ser 
145                 150                 155                 160 


Ser Gly Ser Ile Ala Gly Phe Glu Thr Val Thr Trp Ser Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Ser Leu Gln Trp Val Ala Ser Met Thr Lys Thr Asn Asn 
            180                 185                 190         


Glu Ile Tyr Ser Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp 
        195                 200                 205             


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
    210                 215                 220                 


Asp Thr Gly Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly Gln Gly 
225                 230                 235                 240 


Ile Gln Val Thr Val Ser Ser 
                245         


<210>  18
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AA6-E3 heterodimer

<400>  18
caactgcagc tggtagagac agggggcggc ttagttcagc ctggagggtc tctcagactg       60

tcatgcgctg cctctggctt taccttcagt gactacgtga tgacatgggt ccgccaagct      120

ccagggaagg ggcctgagtg gatcgctact attaatacag atggcagcac aatgcgggac      180

gactccacaa aggggcggtt caccatttcc agagacaacg ccaagaatac tctgtacctt      240

cagatgacca gtctgaaacc cgaggacact gctctgtact attgtgcaag aggccgggtg      300

atctctgctt ccgctatcag aggcgcagta aggggccctg gaacacaggt aaccgtttca      360

tccgggggag gcggttcagg cggtggggga tctggcgggg gtggatccca agttcagctg      420

gtcgaatccg ggggcggact ggtccagaca gggggctccc tgaggctctc ctgtgcatct      480

tccggaagca tcgccggctt cgagaccgtg acctggtctc gccaggctcc cgggaagtct      540

ctgcagtggg tcgcttccat gactaagact aacaacgaga tctactctga ctcagtgaaa      600

ggccgcttca tcatttctag agataacgct aaaaacacag tgtatctgca gatgaatagt      660

ctcaaacctg aagacacagg cgtgtatttc tgtaagggtc ctgagctgag gggccagggc      720

atccaggtaa cagtctcgag t                                                741


<210>  19
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABAB binding agent

<400>  19

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr 
            100                 105                 110         


Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Gly Ile 
                165                 170                 175     


Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val Ser Tyr 
            180                 185                 190         


Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp Asp Tyr 
                245                 250                 255     


Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Leu Gln 
        275                 280                 285             


Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    290                 295                 300                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Val Met Thr 
305                 310                 315                 320 


Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile Ala Thr Ile 
                325                 330                 335     


Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Thr 
        355                 360                 365             


Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Gly Arg 
    370                 375                 380                 


Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly Pro Gly Thr 
385                 390                 395                 400 


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            420                 425                 430         


Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser 
        435                 440                 445             


Ile Ala Gly Phe Glu Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys 
    450                 455                 460                 


Ser Leu Gln Trp Val Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr 
465                 470                 475                 480 


Ser Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys 
                485                 490                 495     


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly 
            500                 505                 510         


Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val 
        515                 520                 525             


Thr Val Ser Ser 
    530         


<210>  20
<211>  1596
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ABAB binding agent

<400>  20
caggtacagc tggtggagac ggggggaggg ctggtacaac caggcgggtc actgaggctt       60

tcctgtgccg catctgggtt cacactggat tattcgtcca tagggtggtt tcggcaggct      120

cctggcaaag agcgtgaggg ggtctcatgt attagtagta gtggtgatag cacaaagtac      180

gccgattccg taaagggccg gtttacaacc tccagggata atgctaagaa caccgtatat      240

ctccagatga actctctgaa gcccgacgat acggccgtat attactgtgc ggctttcagg      300

gcgactatgt gcggcgtgtt ccctctgagc ccttacggca aggacgactg gggcaagggg      360

accctggtga ccgtatcctc aggcggtgga gggtctggtg ggggaggctc agggggtgga      420

ggcagccagg tgcaactggt tgaatctggg ggaggcttgg tacaacctgg gggatccctg      480

agactctctt gcgaggcctc cggattcacc ttggactact atggcatcgg ctggttccgc      540

cagcccccag ggaaggagcg ggaggccgtt tcatacatta gtgccagtgc ccggaccata      600

ctgtacgcag actctgtgaa gggacgcttt accatctcta gggacaatgc caaaaatgct      660

gtgtacctgc aaatgaacag cctcaagcgg gaggataccg cagtgtacta ctgcgcgaga      720

cggcgcttct ccgcttctag cgtgaataga tggctggccg acgactacga cgtgtgggga      780

cggggcacac aggtggctgt gtcttccggt ggcggaagcg gagggggcag cgggggtggg      840

agcggtgggg gcagccaact gcagctggta gagacagggg gcggcttagt tcagcctgga      900

gggtctctca gactgtcatg cgctgcctct ggctttacct tcagtgacta cgtgatgaca      960

tgggtccgcc aagctccagg gaaggggcct gagtggatcg ctactattaa tacagatggc     1020

agcacaatgc gggacgactc cacaaagggg cggttcacca tttccagaga caacgccaag     1080

aatactctgt accttcagat gaccagtctg aaacccgagg acactgctct gtactattgt     1140

gcaagaggcc gggtgatctc tgcttccgct atcagaggcg cagtaagggg ccctggaaca     1200

caggtaaccg tttcatccgg gggaggcggt tcaggcggtg ggggatctgg cgggggtgga     1260

tcccaagttc agctggtcga atccgggggc ggactggtcc agacaggggg ctccctgagg     1320

ctctcctgtg catcttccgg aagcatcgcc ggcttcgaga ccgtgacctg gtctcgccag     1380

gctcccggga agtctctgca gtgggtcgct tccatgacta agactaacaa cgagatctac     1440

tctgactcag tgaaaggccg cttcatcatt tctagagata acgctaaaaa cacagtgtat     1500

ctgcagatga atagtctcaa acctgaagac acaggcgtgt atttctgtaa gggtcctgag     1560

ctgaggggcc agggcatcca ggtaacagtc tcgagt                               1596


<210>  21
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Albumin-binding peptide

<400>  21

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Asp 
1               5                   10          


<210>  22
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABAB-Fc binding agent

<400>  22

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr 
            100                 105                 110         


Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Gly Ile 
                165                 170                 175     


Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val Ser Tyr 
            180                 185                 190         


Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp Asp Tyr 
                245                 250                 255     


Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Leu Gln 
        275                 280                 285             


Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    290                 295                 300                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Val Met Thr 
305                 310                 315                 320 


Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile Ala Thr Ile 
                325                 330                 335     


Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys Gly Arg Phe 
            340                 345                 350         


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Thr 
        355                 360                 365             


Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Gly Arg 
    370                 375                 380                 


Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly Pro Gly Thr 
385                 390                 395                 400 


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            420                 425                 430         


Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser 
        435                 440                 445             


Ile Ala Gly Phe Glu Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys 
    450                 455                 460                 


Ser Leu Gln Trp Val Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr 
465                 470                 475                 480 


Ser Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys 
                485                 490                 495     


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly 
            500                 505                 510         


Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val 
        515                 520                 525             


Thr Val Ser Ser Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    530                 535                 540                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
545                 550                 555                 560 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                565                 570                 575     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            580                 585                 590         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        595                 600                 605             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    610                 615                 620                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
625                 630                 635                 640 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                645                 650                 655     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            660                 665                 670         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        675                 680                 685             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    690                 695                 700                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
705                 710                 715                 720 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                725                 730                 735     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            740                 745                 750         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        755                 760     


<210>  23
<211>  2286
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ABAB-Fc binding agent

<400>  23
caggtacagc tggtggagac ggggggaggg ctggtacaac caggcgggtc actgaggctt       60

tcctgtgccg catctgggtt cacactggat tattcgtcca tagggtggtt tcggcaggct      120

cctggcaaag agcgtgaggg ggtctcatgt attagtagta gtggtgatag cacaaagtac      180

gccgattccg taaagggccg gtttacaacc tccagggata atgctaagaa caccgtatat      240

ctccagatga actctctgaa gcccgacgat acggccgtat attactgtgc ggctttcagg      300

gcgactatgt gcggcgtgtt ccctctgagc ccttacggca aggacgactg gggcaagggg      360

accctggtga ccgtatcctc aggcggtgga gggtctggtg ggggaggctc agggggtgga      420

ggcagccagg tgcaactggt tgaatctggg ggaggcttgg tacaacctgg gggatccctg      480

agactctctt gcgaggcctc cggattcacc ttggactact atggcatcgg ctggttccgc      540

cagcccccag ggaaggagcg ggaggccgtt tcatacatta gtgccagtgc ccggaccata      600

ctgtacgcag actctgtgaa gggacgcttt accatctcta gggacaatgc caaaaatgct      660

gtgtacctgc aaatgaacag cctcaagcgg gaggataccg cagtgtacta ctgcgcgaga      720

cggcgcttct ccgcttctag cgtgaataga tggctggccg acgactacga cgtgtgggga      780

cggggcacac aggtggctgt gtcttccggt ggcggaagcg gagggggcag cgggggtggg      840

agcggtgggg gcagccaact gcagctggta gagacagggg gcggcttagt tcagcctgga      900

gggtctctca gactgtcatg cgctgcctct ggctttacct tcagtgacta cgtgatgaca      960

tgggtccgcc aagctccagg gaaggggcct gagtggatcg ctactattaa tacagatggc     1020

agcacaatgc gggacgactc cacaaagggg cggttcacca tttccagaga caacgccaag     1080

aatactctgt accttcagat gaccagtctg aaacccgagg acactgctct gtactattgt     1140

gcaagaggcc gggtgatctc tgcttccgct atcagaggcg cagtaagggg ccctggaaca     1200

caggtaaccg tttcatccgg gggaggcggt tcaggcggtg ggggatctgg cgggggtgga     1260

tcccaagttc agctggtcga atccgggggc ggactggtcc agacaggggg ctccctgagg     1320

ctctcctgtg catcttccgg aagcatcgcc ggcttcgaga ccgtgacctg gtctcgccag     1380

gctcccggga agtctctgca gtgggtcgct tccatgacta agactaacaa cgagatctac     1440

tctgactcag tgaaaggccg cttcatcatt tctagagata acgctaaaaa cacagtgtat     1500

ctgcagatga atagtctcaa acctgaagac acaggcgtgt atttctgtaa gggtcctgag     1560

ctgaggggcc agggcatcca ggtaacagtc tcgagcggat ccgacaaaac tcacacatgc     1620

ccaccgtgcc cagcacctga actcctgggg ggaccgtcag tcttcctctt ccccccaaaa     1680

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg     1740

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat     1800

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1860

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1920

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1980

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc     2040

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     2100

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     2160

tatagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     2220

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     2280

aaatga                                                                2286


<210>  24
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D-Fc binding agent

<400>  24

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp 
            100                 105                 110         


Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser Gly 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  25
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5D-Fc binding agent

<400>  25
caggtgcaac tggttgaatc tgggggaggc ttggtacaac ctgggggatc cctgagactc       60

tcttgcgagg cctccggatt caccttggac tactatggca tcggctggtt ccgccagccc      120

ccagggaagg agcgggaggc cgtttcatac attagtgcca gtgcccggac catactgtac      180

gcagactctg tgaagggacg ctttaccatc tctagggaca atgccaaaaa tgctgtgtac      240

ctgcaaatga acagcctcaa gcgggaggat accgcagtgt actactgcgc gagacggcgc      300

ttctccgctt ctagcgtgaa tagatggctg gccgacgact acgacgtgtg gggacggggc      360

acacaggtgg ctgtctcgag cggatccgac aaaactcaca catgcccacc gtgcccagca      420

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      480

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      540

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      600

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      660

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc      720

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg      780

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc      840

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac      900

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc      960

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1020

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1071


<210>  26
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E3-Fc binding agent

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu 
            20                  25                  30          


Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val 
        35                  40                  45              


Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys 
                85                  90                  95      


Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val Thr Val Ser Ser Gly 
            100                 105                 110         


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
        115                 120                 125             


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
    130                 135                 140                 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
145                 150                 155                 160 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
                165                 170                 175     


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
            180                 185                 190         


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
        195                 200                 205             


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
    210                 215                 220                 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
225                 230                 235                 240 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
                245                 250                 255     


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
            260                 265                 270         


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
        275                 280                 285             


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
    290                 295                 300                 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
305                 310                 315                 320 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
                325                 330                 335     


Ser Pro Gly Lys 
            340 


<210>  27
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E3-Fc binding agent

<400>  27
caagttcagc tggtcgaatc cgggggcgga ctggtccaga cagggggctc cctgaggctc       60

tcctgtgcat cttccggaag catcgccggc ttcgagaccg tgacctggtc tcgccaggct      120

cccgggaagt ctctgcagtg ggtcgcttcc atgactaaga ctaacaacga gatctactct      180

gactcagtga aaggccgctt catcatttct agagataacg ctaaaaacac agtgtatctg      240

cagatgaata gtctcaaacc tgaagacaca ggcgtgtatt tctgtaaggg tcctgagctg      300

aggggccagg gcatccaggt aacagtctcg agcggatccg acaaaactca cacatgccca      360

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc      420

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      480

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      540

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc      600

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      660

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag      720

gtgtacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc      780

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg      840

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat      900

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg      960

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1020

tga                                                                   1023


<210>  28
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA6-Fc binding agent

<400>  28

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser Gly Ser Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345                 350 


<210>  29
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AA6-Fc binding agent

<400>  29
caactgcagc tggtagagac agggggcggc ttagttcagc ctggagggtc tctcagactg       60

tcatgcgctg cctctggctt taccttcagt gactacgtga tgacatgggt ccgccaagct      120

ccagggaagg ggcctgagtg gatcgctact attaatacag atggcagcac aatgcgggac      180

gactccacaa aggggcggtt caccatttcc agagacaacg ccaagaatac tctgtacctt      240

cagatgacca gtctgaaacc cgaggacact gctctgtact attgtgcaag aggccgggtg      300

atctctgctt ccgctatcag aggcgcagta aggggccctg gaacacaagt aactgtctcg      360

agcggatccg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga      420

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      480

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      540

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      600

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      660

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      720

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag      780

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      840

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      900

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg      960

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1020

cagaagagcc tctccctgtc tccgggtaaa tga                                  1053


<210>  30
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AH3-Fc binding agent

<400>  30

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr 
            100                 105                 110         


Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  31
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AH3-Fc binding agent

<400>  31
caggtacagc tggtggagac ggggggaggg ctggtacaac caggcgggtc actgaggctt       60

tcctgtgccg catctgggtt cacactggat tattcgtcca tagggtggtt tcggcaggct      120

cctggcaaag agcgtgaggg ggtctcatgt attagtagta gtggtgatag cacaaagtac      180

gccgattccg taaagggccg gtttacaacc tccagggata atgctaagaa caccgtatat      240

ctccagatga actctctgaa gcccgacgat acggccgtat attactgtgc ggctttcagg      300

gcgactatgt gcggcgtgtt ccctctgagc ccttacggca aggacgactg gggcaagggg      360

accctggtga ccgtctcgag cggatccgac aaaactcaca catgcccacc gtgcccagca      420

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      480

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      540

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      600

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      660

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc      720

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg      780

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc      840

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac      900

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc      960

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1020

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1071


<210>  32
<211>  498
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AH3-5D-Fc binding agent

<400>  32

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr 
            100                 105                 110         


Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Gly Ile 
                165                 170                 175     


Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val Ser Tyr 
            180                 185                 190         


Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp Asp Tyr 
                245                 250                 255     


Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser Gly Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  33
<211>  1497
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AH3-5D-Fc binding agent

<400>  33
caggtacagc tggtggagac ggggggaggg ctggtacaac caggcgggtc actgaggctt       60

tcctgtgccg catctgggtt cacactggat tattcgtcca tagggtggtt tcggcaggct      120

cctggcaaag agcgtgaggg ggtctcatgt attagtagta gtggtgatag cacaaagtac      180

gccgattccg taaagggccg gtttacaacc tccagggata atgctaagaa caccgtatat      240

ctccagatga actctctgaa gcccgacgat acggccgtat attactgtgc ggctttcagg      300

gcgactatgt gcggcgtgtt ccctctgagc ccttacggca aggacgactg gggcaagggg      360

accctggtga ccgtatcctc aggcggtgga gggtctggtg ggggaggctc agggggtgga      420

ggcagccagg tgcaactggt tgaatctggg ggaggcttgg tacaacctgg gggatccctg      480

agactctctt gcgaggcctc cggattcacc ttggactact atggcatcgg ctggttccgc      540

cagcccccag ggaaggagcg ggaggccgtt tcatacatta gtgccagtgc ccggaccata      600

ctgtacgcag actctgtgaa gggacgcttt accatctcta gggacaatgc caaaaatgct      660

gtgtacctgc aaatgaacag cctcaagcgg gaggataccg cagtgtacta ctgcgcgaga      720

cggcgcttct ccgcttctag cgtgaataga tggctggccg acgactacga cgtgtgggga      780

cggggcacac aggtggctgt ctcgagcgga tccgacaaaa ctcacacatg cccaccgtgc      840

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac      900

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa      960

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1020

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1080

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca     1140

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1200

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc     1260

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1320

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctatagcaag     1380

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1440

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatga        1497


<210>  34
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA6-E3-Fc binding agent

<400>  34

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ser 
145                 150                 155                 160 


Ser Gly Ser Ile Ala Gly Phe Glu Thr Val Thr Trp Ser Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Ser Leu Gln Trp Val Ala Ser Met Thr Lys Thr Asn Asn 
            180                 185                 190         


Glu Ile Tyr Ser Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp 
        195                 200                 205             


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
    210                 215                 220                 


Asp Thr Gly Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly Gln Gly 
225                 230                 235                 240 


Ile Gln Val Thr Val Ser Ser Gly Ser Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  35
<211>  1431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AA6-E3-Fc binding agent

<400>  35
caactgcagc tggtagagac agggggcggc ttagttcagc ctggagggtc tctcagactg       60

tcatgcgctg cctctggctt taccttcagt gactacgtga tgacatgggt ccgccaagct      120

ccagggaagg ggcctgagtg gatcgctact attaatacag atggcagcac aatgcgggac      180

gactccacaa aggggcggtt caccatttcc agagacaacg ccaagaatac tctgtacctt      240

cagatgacca gtctgaaacc cgaggacact gctctgtact attgtgcaag aggccgggtg      300

atctctgctt ccgctatcag aggcgcagta aggggccctg gaacacaggt aaccgtttca      360

tccgggggag gcggttcagg cggtggggga tctggcgggg gtggatccca agttcagctg      420

gtcgaatccg ggggcggact ggtccagaca gggggctccc tgaggctctc ctgtgcatct      480

tccggaagca tcgccggctt cgagaccgtg acctggtctc gccaggctcc cgggaagtct      540

ctgcagtggg tcgcttccat gactaagact aacaacgaga tctactctga ctcagtgaaa      600

ggccgcttca tcatttctag agataacgct aaaaacacag tgtatctgca gatgaatagt      660

ctcaaacctg aagacacagg cgtgtatttc tgtaagggtc ctgagctgag gggccagggc      720

atccaggtaa cagtctcgag cggatccgac aaaactcaca catgcccacc gtgcccagca      780

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      840

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      900

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      960

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1020

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc     1080

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1140

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc     1200

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1260

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc     1320

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1380

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaatg a              1431


<210>  36
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AH3-IgG1-heavy chain

<400>  36

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr 
            100                 105                 110         


Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  37
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AH3-IgG1-heavy chain

<400>  37
caggtacagc tggtggagac ggggggaggg ctggtacaac caggcgggtc actgaggctt       60

tcctgtgccg catctgggtt cacactggat tattcgtcca tagggtggtt tcggcaggct      120

cctggcaaag agcgtgaggg ggtctcatgt attagtagta gtggtgatag cacaaagtac      180

gccgattccg taaagggccg gtttacaacc tccagggata atgctaagaa caccgtatat      240

ctccagatga actctctgaa gcccgacgat acggccgtat attactgtgc ggctttcagg      300

gcgactatgt gcggcgtgtt ccctctgagc ccttacggca aggacgactg gggcaagggg      360

accctggtga ccgtctcgag tgcgtcgacc aagggcccat cggtcttccc gctagcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaacctg tgacggtctc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggtaa atga           1374


<210>  38
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D-IgG1-heavy chain

<400>  38

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp 
            100                 105                 110         


Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser Ala 
        115                 120                 125             


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
    130                 135                 140                 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
145                 150                 155                 160 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
                165                 170                 175     


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
            180                 185                 190         


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
        195                 200                 205             


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
    210                 215                 220                 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  39
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5D-IgG1-heavy chain

<400>  39
caggtgcaac tggttgaatc tgggggaggc ttggtacaac ctgggggatc cctgagactc       60

tcttgcgagg cctccggatt caccttggac tactatggca tcggctggtt ccgccagccc      120

ccagggaagg agcgggaggc cgtttcatac attagtgcca gtgcccggac catactgtac      180

gcagactctg tgaagggacg ctttaccatc tctagggaca atgccaaaaa tgctgtgtac      240

ctgcaaatga acagcctcaa gcgggaggat accgcagtgt actactgcgc gagacggcgc      300

ttctccgctt ctagcgtgaa tagatggctg gccgacgact acgacgtgtg gggacggggc      360

acacaggtgg ctgtctcgag cgcgtcgacc aagggcccat cggtcttccc gctagcaccc      420

tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa ggactacttc      480

cccgaacctg tgacggtctc gtggaactca ggcgccctga ccagcggcgt gcacaccttc      540

ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac cgtgccctcc      600

agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag caacaccaag      660

gtggacaaga gagttgagcc caaatcttgt gacaaaactc acacatgccc accgtgccca      720

gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      780

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      840

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      900

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      960

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1020

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1080

ctgcccccat cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1140

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1200

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta tagcaagctc     1260

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1320

gctctgcaca accactacac gcagaagagc ctctccctgt ccccgggtaa atga           1374


<210>  40
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA6-IgG1-kappa chain

<400>  40

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser Arg Thr Val Ala Ala Pro Ser 
        115                 120                 125             


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
    130                 135                 140                 


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
145                 150                 155                 160 


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
                165                 170                 175     


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
            180                 185                 190         


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
        195                 200                 205             


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
    210                 215                 220                 


Arg Gly Glu Cys 
225             


<210>  41
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AA6-IgG1-kappa chain

<400>  41
caactgcagc tggtagagac agggggcggc ttagttcagc ctggagggtc tctcagactg       60

tcatgcgctg cctctggctt taccttcagt gactacgtga tgacatgggt ccgccaagct      120

ccagggaagg ggcctgagtg gatcgctact attaatacag atggcagcac aatgcgggac      180

gactccacaa aggggcggtt caccatttcc agagacaacg ccaagaatac tctgtacctt      240

cagatgacca gtctgaaacc cgaggacact gctctgtact attgtgcaag aggccgggtg      300

atctctgctt ccgctatcag aggcgcagta aggggccctg gaacacaagt aactgtctcg      360

agccgtacgg tggctgcacc atctgtcttc atcttcccgc catctgatga gcagttgaaa      420

tctggaactg cctctgttgt gtgcctgctg aataacttct atcccagaga ggccaaagta      480

cagtggaagg tggataacgc cctccaatcg ggtaactccc aggagagtgt cacagagcag      540

gacagcaagg acagcaccta cagcctcagc agcaccctga cgctgagcaa agcagactac      600

gagaaacaca aagtctacgc ctgcgaagtc acccatcagg gcctgagctc gcccgtcaca      660

aagagcttca acaggggaga gtgttga                                          687


<210>  42
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E3-IgG1-kappa chain

<400>  42

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu 
            20                  25                  30          


Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val 
        35                  40                  45              


Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys 
                85                  90                  95      


Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val Thr Val Ser Ser Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  43
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E3-IgG1-kappa chain

<400>  43
caagttcagc tggtcgaatc cgggggcgga ctggtccaga cagggggctc cctgaggctc       60

tcctgtgcat cttccggaag catcgccggc ttcgagaccg tgacctggtc tcgccaggct      120

cccgggaagt ctctgcagtg ggtcgcttcc atgactaaga ctaacaacga gatctactct      180

gactcagtga aaggccgctt catcatttct agagataacg ctaaaaacac agtgtatctg      240

cagatgaata gtctcaaacc tgaagacaca ggcgtgtatt tctgtaaggg tcctgagctg      300

aggggccagg gcatccaggt aacagtctcg agccgtacgg tggctgcacc atctgtcttc      360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttga         657


<210>  44
<211>  599
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AH3-5D-IgG1 heavy chain

<400>  44

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser 
            20                  25                  30          


Ser Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr 
            100                 105                 110         


Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    130                 135                 140                 


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
145                 150                 155                 160 


Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Gly Ile 
                165                 170                 175     


Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val Ser Tyr 
            180                 185                 190         


Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp Asp Tyr 
                245                 250                 255     


Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser Ala Ser Thr 
            260                 265                 270         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
        275                 280                 285             


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    290                 295                 300                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
305                 310                 315                 320 


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
                325                 330                 335     


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
            340                 345                 350         


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
        355                 360                 365             


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    370                 375                 380                 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
385                 390                 395                 400 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                405                 410                 415     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            420                 425                 430         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        435                 440                 445             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    450                 455                 460                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
465                 470                 475                 480 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                485                 490                 495     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            500                 505                 510         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        515                 520                 525             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    530                 535                 540                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
545                 550                 555                 560 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                565                 570                 575     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            580                 585                 590         


Leu Ser Leu Ser Pro Gly Lys 
        595                 


<210>  45
<211>  1800
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AH3-5D-IgG1 heavy chain

<400>  45
caggtacagc tggtggagac ggggggaggg ctggtacaac caggcgggtc actgaggctt       60

tcctgtgccg catctgggtt cacactggat tattcgtcca tagggtggtt tcggcaggct      120

cctggcaaag agcgtgaggg ggtctcatgt attagtagta gtggtgatag cacaaagtac      180

gccgattccg taaagggccg gtttacaacc tccagggata atgctaagaa caccgtatat      240

ctccagatga actctctgaa gcccgacgat acggccgtat attactgtgc ggctttcagg      300

gcgactatgt gcggcgtgtt ccctctgagc ccttacggca aggacgactg gggcaagggg      360

accctggtga ccgtatcctc aggcggtgga gggtctggtg ggggaggctc agggggtgga      420

ggcagccagg tgcaactggt tgaatctggg ggaggcttgg tacaacctgg gggatccctg      480

agactctctt gcgaggcctc cggattcacc ttggactact atggcatcgg ctggttccgc      540

cagcccccag ggaaggagcg ggaggccgtt tcatacatta gtgccagtgc ccggaccata      600

ctgtacgcag actctgtgaa gggacgcttt accatctcta gggacaatgc caaaaatgct      660

gtgtacctgc aaatgaacag cctcaagcgg gaggataccg cagtgtacta ctgcgcgaga      720

cggcgcttct ccgcttctag cgtgaataga tggctggccg acgactacga cgtgtgggga      780

cggggcacac aggtggctgt ctcgagcgcg tcgaccaagg gcccatcggt cttcccgcta      840

gcaccctcct ccaagagcac ctctgggggc acagcggccc tgggctgcct ggtcaaggac      900

tacttccccg aacctgtgac ggtctcgtgg aactcaggcg ccctgaccag cggcgtgcac      960

accttcccgg ctgtcctaca gtcctcagga ctctactccc tcagcagcgt ggtgaccgtg     1020

ccctccagca gcttgggcac ccagacctac atctgcaacg tgaatcacaa gcccagcaac     1080

accaaggtgg acaagagagt tgagcccaaa tcttgtgaca aaactcacac atgcccaccg     1140

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag     1200

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     1260

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1320

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1380

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1440

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1500

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     1560

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1620

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc     1680

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1740

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtcccc gggtaaatga     1800


<210>  46
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AA6-E3-IgG1 light chain

<400>  46

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
    130                 135                 140                 


Gly Gly Leu Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ser 
145                 150                 155                 160 


Ser Gly Ser Ile Ala Gly Phe Glu Thr Val Thr Trp Ser Arg Gln Ala 
                165                 170                 175     


Pro Gly Lys Ser Leu Gln Trp Val Ala Ser Met Thr Lys Thr Asn Asn 
            180                 185                 190         


Glu Ile Tyr Ser Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp 
        195                 200                 205             


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
    210                 215                 220                 


Asp Thr Gly Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly Gln Gly 
225                 230                 235                 240 


Ile Gln Val Thr Val Ser Ser Arg Thr Val Ala Ala Pro Ser Val Phe 
                245                 250                 255     


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
            260                 265                 270         


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
        275                 280                 285             


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
    290                 295                 300                 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
305                 310                 315                 320 


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
                325                 330                 335     


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
            340                 345                 350         


Glu Cys 
        


<210>  47
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AA6-E3-IgG1 light chain

<400>  47
caactgcagc tggtagagac agggggcggc ttagttcagc ctggagggtc tctcagactg       60

tcatgcgctg cctctggctt taccttcagt gactacgtga tgacatgggt ccgccaagct      120

ccagggaagg ggcctgagtg gatcgctact attaatacag atggcagcac aatgcgggac      180

gactccacaa aggggcggtt caccatttcc agagacaacg ccaagaatac tctgtacctt      240

cagatgacca gtctgaaacc cgaggacact gctctgtact attgtgcaag aggccgggtg      300

atctctgctt ccgctatcag aggcgcagta aggggccctg gaacacaggt aaccgtttca      360

tccgggggag gcggttcagg cggtggggga tctggcgggg gtggatccca agttcagctg      420

gtcgaatccg ggggcggact ggtccagaca gggggctccc tgaggctctc ctgtgcatct      480

tccggaagca tcgccggctt cgagaccgtg acctggtctc gccaggctcc cgggaagtct      540

ctgcagtggg tcgcttccat gactaagact aacaacgaga tctactctga ctcagtgaaa      600

ggccgcttca tcatttctag agataacgct aaaaacacag tgtatctgca gatgaatagt      660

ctcaaacctg aagacacagg cgtgtatttc tgtaagggtc ctgagctgag gggccagggc      720

atccaggtaa cagtctcgag ccgtacggtg gctgcaccat ctgtcttcat cttcccgcca      780

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      840

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      900

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      960

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     1020

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttga                     1065


<210>  48
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH peptide monomer 5D

<400>  48

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu Ala Asp 
            100                 105                 110         


Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser Ser 
        115                 120                 125         


<210>  49
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH peptide monomer 5D

<400>  49
caggtgcagc tcgtggagtc aggtggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgaag cctctggatt cactttggat tattatggta taggctggtt ccgccagccc      120

ccagggaagg agcgcgaggc ggtctcatat attagtgcca gtgcccgtac gatattgtat      180

gcagattccg tgaagggccg atttaccatc tccagagaca atgccaagaa cgcggtgtat      240

ctacaaatga acagcctgaa acgtgaggac acggctgtct attactgtgc gaggcggcga      300

ttctccgcgt ctagtgttaa tagatggctt gccgacgact atgacgtctg gggtcggggg      360

acccaggtcg cggtgtcctc a                                                381


<210>  50
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH peptide monomer E3

<400>  50

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu 
            20                  25                  30          


Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val 
        35                  40                  45              


Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys 
                85                  90                  95      


Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val Thr Val Ser Ser 
            100                 105                 110     


<210>  51
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH peptide monomer E3

<400>  51
caggtgcagc tcgtggagtc gggcggaggc ttggtgcaga ctggggggtc tctgagactc       60

tcctgtgcat cctctggaag tatcgccggt ttcgaaaccg tgacctggtc ccgccaggct      120

cctggaaagt cgctccagtg ggtcgcatcg atgactaaaa ctaataacga gatctattca      180

gactccgtga agggccgatt catcatctcc agagacaacg ccaagaatac ggtgtatcta      240

caaatgaaca gcctgaaacc tgaggacaca ggcgtctatt tttgtaaagg tcctgagttg      300

aggggccagg ggatccaggt caccgtctcc tcg                                   333


<210>  52
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH peptide monomer AA6

<400>  52

Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile 
        35                  40                  45              


Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg Asp Asp Ser Thr Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg Gly Ala Val Arg Gly 
            100                 105                 110         


Pro Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  53
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH peptide monomer AA6

<400>  53
cagttgcagc tcgtggagac agggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cacgttcagt gactacgtca tgacctgggt ccgccaggct      120

ccaggaaagg ggcccgaatg gatcgcaact attaatacgg acggtagcac gatgcgtgat      180

gactccacaa aaggccgatt caccatctcc agagacaacg ccaagaacac actgtatctg      240

caaatgacca gcctgaaacc ggaggacacg gccctgtatt actgtgcgag aggccgcgtg      300

atctccgcct ccgcgataag aggggcggtt aggggcccgg ggacccaggt caccgtctcc      360

tca                                                                    363


<210>  54
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH peptide monomer AH3

<400>  54

Gln Val Gln Leu Val Glu Thr Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser Ser 
            20                  25                  30          


Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
        35                  40                  45              


Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Phe Arg Ala Thr Met Cys Gly Val Phe Pro Leu Ser Pro Tyr Gly 
            100                 105                 110         


Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  55
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH peptide monomer AH3

<400>  55
caggtgcagc tcgtggagac ggggggcttg gtgcagcctg gggggtctct gagactctcc       60

tgtgcagcct ctggattcac tttggattat tcgtccatag gctggttccg ccaggcccca      120

gggaaggagc gtgagggggt ctcatgtatt agtagtagtg gtgatagcac aaagtatgca      180

gactccgtga agggccgatt caccacctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgacgacaca gccgtttatt actgtgcagc ttttagggcg      300

actatgtgcg gcgtgttccc ccttagcccc tacggcaagg acgactgggg caaagggacc      360

ctggtcaccg tctcctca                                                    378


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker 1

<400>  56

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  57
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flexible linker 1

<400>  57
ggcggtggtg gctctggtgg cggcggttcc ggtggcggtg gcagc                       45


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker 2

<400>  58

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  59
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flexible linker 2

<400>  59
ggtggaggcg gttcaggcgg aggtggctct ggcggtggcg gttcc                       45


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker 3

<400>  60

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  61
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flexible linker 3

<400>  61
ggcggtggtg gctctggtgg cggcggttcc ggtggcggtg gcagc                       45


<210>  62
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5D-E3 heterodimer

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr 
65                  70                  75                  80  


Leu Gln Met Glu Thr Asn Ser Leu Lys Arg Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg Trp Leu 
            100                 105                 110         


Ala Asp Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val Ala Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu 
                165                 170                 175     


Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val 
            180                 185                 190         


Ala Ser Met Glu Thr Thr Lys Thr Asn Asn Glu Ile Tyr Ser Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
    210                 215                 220                 


Tyr Leu Gln Met Glu Thr Asn Ser Leu Lys Pro Glu Asp Thr Gly Val 
225                 230                 235                 240 


Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  63
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5D-E3 heterodimer

<400>  63
caggtgcagc tcgtggagtc aggtggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgaag cctctggatt cactttggat tattatggta taggctggtt ccgccagccc      120

ccagggaagg agcgcgaggc ggtctcatat attagtgcca gtgcccgtac gatattgtat      180

gcagattccg tgaagggccg atttaccatc tccagagaca atgccaagaa cgcggtgtat      240

ctacaaatga acagcctgaa acgtgaggac acggctgtct attactgtgc gaggcggcga      300

ttctccgcgt ctagtgttaa tagatggctt gccgacgact atgacgtctg gggtcggggg      360

acccaggtcg cggtgtcctc aggcggtggt ggctctggtg gcggcggttc cggtggcggt      420

ggcagccagg tgcagctcgt ggagtcgggc ggaggcttgg tgcagactgg ggggtctctg      480

agactctcct gtgcatcctc tggaagtatc gccggtttcg aaaccgtgac ctggtcccgc      540

caggctcctg gaaagtcgct ccagtgggtc gcatcgatga ctaaaactaa taacgagatc      600

tattcagact ccgtgaaggg ccgattcatc atctccagag acaacgccaa gaatacggtg      660

tatctacaaa tgaacagcct gaaacctgag gacacaggcg tctatttttg taaaggtcct      720

gagttgaggg gccaggggat ccaggtcacc gtctcctcg                             759


<210>  64
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AH3-AA6 heterodimer

<400>  64

Gln Val Gln Leu Val Glu Thr Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser Ser 
            20                  25                  30          


Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
        35                  40                  45              


Cys Ile Ser Ser Ser Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Glu Thr Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Phe Arg Ala Thr Met Glu Thr Cys Gly Val Phe Pro Leu 
            100                 105                 110         


Ser Pro Tyr Gly Lys Asp Asp Trp Gly Lys Gly Thr Leu Val Thr Val 
        115                 120                 125             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Leu Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp 
                165                 170                 175     


Tyr Val Met Glu Thr Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Pro 
            180                 185                 190         


Glu Trp Ile Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Glu Thr Arg 
        195                 200                 205             


Asp Asp Ser Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Asn Thr Leu Tyr Leu Gln Met Glu Thr Thr Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ala Arg Gly Arg Val Ile Ser Ala Ser Ala 
                245                 250                 255     


Ile Arg Gly Ala Val Arg Gly Pro Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


<210>  65
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AH3-AA6 heterodimer

<400>  65
caggtgcagc tcgtggagac ggggggcttg gtgcagcctg gggggtctct gagactctcc       60

tgtgcagcct ctggattcac tttggattat tcgtccatag gctggttccg ccaggcccca      120

gggaaggagc gtgagggggt ctcatgtatt agtagtagtg gtgatagcac aaagtatgca      180

gactccgtga agggccgatt caccacctcc agagacaacg ccaagaacac ggtgtatctg      240

caaatgaaca gcctgaaacc tgacgacaca gccgtttatt actgtgcagc ttttagggcg      300

actatgtgcg gcgtgttccc ccttagcccc tacggcaagg acgactgggg caaagggacc      360

ctggtcaccg tctcctcagg cggtggtggc tctggtggcg gcggttccgg tggcggtggc      420

agccagttgc agctcgtgga gacaggggga ggcttggtgc agcctggggg gtctctgaga      480

ctctcctgtg cagcctctgg attcacgttc agtgactacg tcatgacctg ggtccgccag      540

gctccaggaa aggggcccga atggatcgca actattaata cggacggtag cacgatgcgt      600

gatgactcca caaaaggccg attcaccatc tccagagaca acgccaagaa cacactgtat      660

ctgcaaatga ccagcctgaa accggaggac acggccctgt attactgtgc gagaggccgc      720

gtgatctccg cctccgcgat aagaggggcg gttaggggcc cggggaccca ggtcaccgtc      780

tcctca                                                                 786


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  six-histidine tag

<400>  66

His His His His His His 
1               5       


<210>  67
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E-tag for protein purification

<400>  67

Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


