                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Inc.
       Vidyasagar, Sadasivan
       Okunieff, Paul
       Vidyasagar, Anand
 
<120>  Use of NHE3 as a Biomarker for Radiation Biodosimetry

<130>  UF.1198XPCT

<150>  62/112,467
<151>  2015-02-05

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  834
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Gly Leu Gly Ala Arg Gly Pro Asp Arg Gly Leu Leu Leu Ala 
1               5                   10                  15      


Leu Ala Leu Gly Gly Leu Ala Arg Ala Gly Gly Val Glu Val Glu Pro 
            20                  25                  30          


Gly Gly Ala His Gly Glu Ser Gly Gly Phe Gln Val Val Thr Phe Glu 
        35                  40                  45              


Trp Ala His Val Gln Asp Pro Tyr Val Ile Ala Leu Trp Ile Leu Val 
    50                  55                  60                  


Ala Ser Leu Ala Lys Ile Gly Phe His Leu Ser His Lys Val Thr Ser 
65                  70                  75                  80  


Val Val Pro Glu Ser Ala Leu Leu Ile Val Leu Gly Leu Val Leu Gly 
                85                  90                  95      


Gly Ile Val Trp Ala Ala Asp His Ile Ala Ser Phe Thr Leu Thr Pro 
            100                 105                 110         


Thr Val Phe Phe Phe Tyr Leu Leu Pro Pro Ile Val Leu Asp Ala Gly 
        115                 120                 125             


Tyr Phe Met Pro Asn Arg Leu Phe Phe Gly Asn Leu Gly Thr Ile Leu 
    130                 135                 140                 


Leu Tyr Ala Val Val Gly Thr Val Trp Asn Ala Ala Thr Thr Gly Leu 
145                 150                 155                 160 


Ser Leu Tyr Gly Val Phe Leu Ser Gly Leu Met Gly Asp Leu Gln Ile 
                165                 170                 175     


Gly Leu Leu Asp Phe Leu Leu Phe Gly Ser Leu Met Ala Ala Val Asp 
            180                 185                 190         


Pro Val Ala Val Leu Ala Val Phe Glu Glu Val His Val Asn Glu Val 
        195                 200                 205             


Leu Phe Ile Ile Val Phe Gly Glu Ser Leu Leu Asn Asp Ala Val Thr 
    210                 215                 220                 


Val Val Leu Tyr Asn Val Phe Glu Ser Phe Val Ala Leu Gly Gly Asp 
225                 230                 235                 240 


Asn Val Thr Gly Val Asp Cys Val Lys Gly Ile Val Ser Phe Phe Val 
                245                 250                 255     


Val Ser Leu Gly Gly Thr Leu Val Gly Val Val Phe Ala Phe Leu Leu 
            260                 265                 270         


Ser Leu Val Thr Arg Phe Thr Lys His Val Arg Ile Ile Glu Pro Gly 
        275                 280                 285             


Phe Val Phe Ile Ile Ser Tyr Leu Ser Tyr Leu Thr Ser Glu Met Leu 
    290                 295                 300                 


Ser Leu Ser Ala Ile Leu Ala Ile Thr Phe Cys Gly Ile Cys Cys Gln 
305                 310                 315                 320 


Lys Tyr Val Lys Ala Asn Ile Ser Glu Gln Ser Ala Thr Thr Val Arg 
                325                 330                 335     


Tyr Thr Met Lys Met Leu Ala Ser Ser Ala Glu Thr Ile Ile Phe Met 
            340                 345                 350         


Phe Leu Gly Ile Ser Ala Val Asn Pro Phe Ile Trp Thr Trp Asn Thr 
        355                 360                 365             


Ala Phe Val Leu Leu Thr Leu Val Phe Ile Ser Val Tyr Arg Ala Ile 
    370                 375                 380                 


Gly Val Val Leu Gln Thr Trp Leu Leu Asn Arg Tyr Arg Met Val Gln 
385                 390                 395                 400 


Leu Glu Pro Ile Asp Gln Val Val Leu Ser Tyr Gly Gly Leu Arg Gly 
                405                 410                 415     


Ala Val Ala Phe Ala Leu Val Val Leu Leu Asp Gly Asp Lys Val Lys 
            420                 425                 430         


Glu Lys Asn Leu Phe Val Ser Thr Thr Ile Ile Val Val Phe Phe Thr 
        435                 440                 445             


Val Ile Phe Gln Gly Leu Thr Ile Lys Pro Leu Val Gln Trp Leu Lys 
    450                 455                 460                 


Val Lys Arg Ser Glu His Arg Glu Pro Arg Leu Asn Glu Lys Leu His 
465                 470                 475                 480 


Gly Arg Ala Phe Asp His Ile Leu Ser Ala Ile Glu Asp Ile Ser Gly 
                485                 490                 495     


Gln Ile Gly His Asn Tyr Leu Arg Asp Lys Trp Ser His Phe Asp Arg 
            500                 505                 510         


Lys Phe Leu Ser Arg Val Leu Met Arg Arg Ser Ala Gln Lys Ser Arg 
        515                 520                 525             


Asp Arg Ile Leu Asn Val Phe His Glu Leu Asn Leu Lys Asp Ala Ile 
    530                 535                 540                 


Ser Tyr Val Ala Glu Gly Glu Arg Arg Gly Ser Leu Ala Phe Ile Arg 
545                 550                 555                 560 


Ser Pro Ser Thr Asp Asn Val Val Asn Val Asp Phe Thr Pro Arg Ser 
                565                 570                 575     


Ser Thr Val Glu Ala Ser Val Ser Tyr Leu Leu Arg Glu Asn Val Ser 
            580                 585                 590         


Ala Val Cys Leu Asp Met Gln Ser Leu Glu Gln Arg Arg Arg Ser Ile 
        595                 600                 605             


Arg Asp Ala Glu Asp Met Val Thr His His Thr Leu Gln Gln Tyr Leu 
    610                 615                 620                 


Tyr Lys Pro Arg Gln Glu Tyr Lys His Leu Tyr Ser Arg His Glu Leu 
625                 630                 635                 640 


Thr Pro Thr Glu Asp Glu Lys Gln Asp Arg Glu Ile Phe His Arg Thr 
                645                 650                 655     


Met Arg Lys Arg Leu Glu Ser Phe Lys Ser Thr Lys Leu Gly Leu Asn 
            660                 665                 670         


Gln Asn Lys Lys Ala Ala Lys Leu Tyr Lys Arg Glu Arg Ala Gln Lys 
        675                 680                 685             


Arg Arg Asn Ser Ser Ile Pro Asn Gly Lys Leu Pro Met Glu Ser Pro 
    690                 695                 700                 


Ala Gln Asn Phe Thr Ile Lys Glu Lys Asp Leu Glu Leu Ser Asp Thr 
705                 710                 715                 720 


Glu Glu Pro Pro Asn Tyr Asp Glu Glu Met Ser Gly Gly Ile Glu Phe 
                725                 730                 735     


Leu Ala Ser Val Thr Lys Asp Thr Ala Ser Asp Ser Pro Ala Gly Ile 
            740                 745                 750         


Asp Asn Pro Val Phe Ser Pro Asp Glu Ala Leu Asp Arg Ser Leu Leu 
        755                 760                 765             


Ala Arg Leu Pro Pro Trp Leu Ser Pro Gly Glu Thr Val Val Pro Ser 
    770                 775                 780                 


Gln Arg Ala Arg Thr Gln Ile Pro Tyr Ser Pro Gly Thr Phe Cys Arg 
785                 790                 795                 800 


Leu Met Pro Phe Arg Leu Ser Ser Lys Ser Val Asp Ser Phe Leu Gln 
                805                 810                 815     


Ala Asp Gly Pro Glu Glu Arg Pro Pro Ala Ala Leu Pro Glu Ser Thr 
            820                 825                 830         


His Met 
        


<210>  2
<211>  2777
<212>  DNA
<213>  Homo sapiens

<400>  2
ccggcaccgg agcgcgccgg gtcctcgccg ggtcccagcc ccgcgcgtcg gcccagccca       60

gccgggaccc cccgcgacat gcgcgtccca gccctgcgct gagcaggcgg caatgtgggg      120

actcggggcc cggggccccg accgggggct gctgctggcg ctggcgctgg gcgggctggc      180

gcgggccggg ggcgtcgagg tggagcccgg cggcgcgcac ggcgagagcg ggggcttcca      240

ggtggtcacc ttcgagtggg cccacgtgca ggatccctac gtcatcgcgc tctggatcct      300

cgtggccagc ttggccaaga tcgggttcca cctgtcccac aaggtcacca gcgtggttcc      360

cgagagcgcc ctgctcatcg tgctgggcct ggtgctgggc ggcatcgtct gggcggccga      420

ccacatcgcg tccttcacac tgacgcccac cgtcttcttc ttctacctgc tgccccccat      480

cgtgctggac gccggctact tcatgcccaa ccgcctcttc ttcggcaacc tggggaccat      540

cctgttgtac gccgtcgtgg gtaccgtgtg gaacgcggcc accaccgggc tgtccctcta      600

cggcgtcttc ctcagtgggc tcatgggcga cctgcagatt gggctgctgg acttcctcct      660

gtttggcagc ctcatggcgg ctgtggaccc ggtggccgtc ctggccgtgt ttgaggaggt      720

ccatgtcaac gaggtcctgt tcatcatcgt cttcggggag tcgctgctga acgacgcagt      780

caccgtggtt ctgtacaatg tgtttgaatc tttcgtggcg ctgggaggtg acaacgtgac      840

tggcgtggac tgcgtgaagg gcatagtgtc cttcttcgtg gtgagcctgg ggggcacgct      900

ggtgggggtg gtcttcgcct tcctgctgtc gctggtgacg cgcttcacca agcatgtgcg      960

tatcatcgag cccggcttcg tgttcatcat ctcctacctg tcctacctga cgtccgagat     1020

gctgtcgctg tcggccatcc tcgccatcac cttctgtggc atctgctgtc agaagtatgt     1080

gaaggccaac atctcggagc agtcggccac caccgtgcgc tacaccatga agatgctggc     1140

cagcagcgcc gagaccatca tcttcatgtt cctgggtatc tcggccgtga acccgttcat     1200

ctggacctgg aacacggcct tcgtgctcct gacgctggtc ttcatctccg tgtaccgggc     1260

catcggtgtg gtcctgcaga cctggcttct gaaccgctac cgcatggtgc agctggagcc     1320

cattgaccag gtggtcctgt cctacggggg cctgcgcggg gccgtggcct ttgccctggt     1380

ggtgcttctg gatggagaca aggtcaagga gaagaacctg ttcgtcagca ccaccatcat     1440

cgtagtgttc ttcaccgtca tcttccaggg cctgaccatc aagcctctgg tgcagtggct     1500

gaaggtgaag aggagcgagc accgggaacc tcggctcaac gagaagctgc acgggcgcgc     1560

tttcgaccac atcctctcgg ccatcgagga catatccgga cagatcgggc acaattatct     1620

cagagacaag tggtcccact tcgacaggaa gttcctcagc agggtcctca tgagacggtc     1680

ggcccagaag tctcgagacc ggatcctgaa tgtcttccac gagctgaacc tgaaggatgc     1740

catcagctac gtggctgagg gagagcgccg cgggtccctg gccttcatcc gctcccccag     1800

caccgacaac gtggtcaacg tggacttcac gccacgatcg tccaccgtgg aggcctctgt     1860

ctcctacctc ctgagagaaa atgtcagcgc tgtctgcctg gacatgcagt ctctggagca     1920

gcgacggcgg agcatccggg acgcggagga catggtcacg caccacacgc tacagcagta     1980

cctgtacaag ccgcggcagg agtacaagca tctgtacagc cgacacgagc tcacgcccac     2040

ggaggacgag aaacaggacc gggaaatctt ccacaggacc atgcggaagc gcctggagtc     2100

cttcaagtcg accaagctgg ggctcaacca gaacaagaag gcggccaagc tgtacaagcg     2160

ggagcgtgcc cagaagcgga gaaacagcag catccccaat gggaagctgc ccatggagag     2220

ccctgcgcag aatttcacca tcaaggagaa agacttggaa ctttcagaca ccgaggagcc     2280

ccccaactat gatgaggaga tgagtggggg gatcgagttc ctggctagtg tcaccaagga     2340

cacagcgtcc gactcccctg caggaattga caaccctgtg ttttctccgg acgaggccct     2400

ggaccgcagc ctcctggcca ggctgccgcc ctggctgtct cccggggaga cggtggtccc     2460

ctcgcagagg gcccgcacgc agattcccta ctctcccggc accttctgcc gcctgatgcc     2520

cttccgcctc agcagcaagt ccgtggactc cttcctgcag gcagacggcc ccgaggagcg     2580

gccccccgcc gccctccccg agtccacaca catgtgacac cggctccgac acgccgctaa     2640

ccggccgctc gtccccgcgc cacggtccgc ccaccgccgc cgccgctgtc ccagagaaac     2700

cccagatccc cgcgcggcta cagcgaccgc gagccccgag ccccgcctcg cccacgccag     2760

cgcctgcgca gaactcc                                                    2777


