                         SEQUENCE LISTING



<110>  Meiragtx Limited

 

<120>  REGULATION OF GENE EXPRESSION BY APTAMER-MEDIATED MODULATION OF 

       ALTERNATIVE SPLICING



<130>  16485/461WO1



<140>  PCT/US2016/016234

<141>  2016-02-02



<150>  US 62/110,919

<151>  2015-02-02



<160>  64    



<170>  PatentIn version 3.5



<210>  1

<211>  539

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Luci-IVSdelta-Luci in construct Con1 Human beta-globin intron 2 

       containing a deletion ("IVS2delta") is in lowercase and flanking 

       luciferase sequence is in uppercase.



<400>  1

gaggttccat ctgccaggta tcagggtgag tctatgggac ccttgatgtt ttctttcccc       60



ttcttttcta tggttaagtt catgtcatag gaaggggaga agtaacaggg tacacatatt      120



gaccaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata      180



cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag ggcaataatg      240



atacaatgta tcatgcctct ttgcaccatt ctaaagaata acagtgataa tttctgggtt      300



aaggcaatag caatatttct gcatataaat atttctgcat ataaattgta actgatgtaa      360



gaggtttcat attgctaata gcagctacaa tccagctacc attctgcttt tattttatgg      420



ttgggataag gctggattat tctgagtcca agctaggccc ttttgctaat catgttcata      480



cctcttatct tcctcccaca gcaaggatat gggctcactg agactacatc agctattct       539





<210>  2

<211>  521

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Luci-IVSdelta-Luci in construct Con2



<400>  2

gattacaccc gagggggatg ataaagtaag cctatgggac ccttgatgtt ttctttcccc       60



ttcttttcta tggttaagtt catgtcatag gaaggggaga agtaacaggg tacacatatt      120



gaccaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata      180



cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag ggcaataatg      240



atacaatgta tcatgcctct ttgcaccatt ctaaagaata acagtgataa tttctgggtt      300



aaggcaatag caatatttct gcatataaat atttctgcat ataaattgta actgatgtaa      360



gaggtttcat attgctaata gcagctacaa tccagctacc attctgcttt tattttatgg      420



ttgggataag gctggattat tctgagtcca agctaggccc ttttgctaat catgttcata      480



cctcttatct tcctcccaca gccgggcgcg gtcggtaaag t                          521





<210>  3

<211>  510

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Luci-IVSdelta-Luci in construct Con3



<400>  3

ttcttcgcca aaagcagtaa gtctatggga cccttgatgt tttctttccc cttcttttct       60



atggttaagt tcatgtcata ggaaggggag aagtaacagg gtacacatat tgaccaaatc      120



agggtaattt tgcatttgta attttaaaaa atgctttctt cttttaatat acttttttgt      180



ttatcttatt tctaatactt tccctaatct ctttctttca gggcaataat gatacaatgt      240



atcatgcctc tttgcaccat tctaaagaat aacagtgata atttctgggt taaggcaata      300



gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta agaggtttca      360



tattgctaat agcagctaca atccagctac cattctgctt ttattttatg gttgggataa      420



ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcatgttcat acctcttatc      480



ttcctcccac agctctgatt gacaaatacg                                       510





<210>  4

<211>  517

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Luci-IVSdelta-Luci in construct Con4



<400>  4

aagagctgtt tctgaggagg tgtggctatg ggacccttga tgttttcttt ccccttcttt       60



tctatggtta agttcatgtc ataggaaggg gagaagtaac agggtacaca tattgaccaa      120



atcagggtaa ttttgcattt gtaattttaa aaaatgcttt cttcttttaa tatacttttt      180



tgtttatctt atttctaata ctttccctaa tctctttctt tcagggcaat aatgatacaa      240



tgtatcatgc ctctttgcac cattctaaag aataacagtg ataatttctg ggttaaggca      300



atagcaatat ttctgcatat aaatatttct gcatataaat tgtaactgat gtaagaggtt      360



tcatattgct aatagcagct acaatccagc taccattctg cttttatttt atggttggga      420



taaggctgga ttattctgag tccaagctag gcccttttgc taatcatgtt catacctctt      480



atcttcctcc cacagccttc aggattacaa gattcaa                               517





<210>  5

<211>  519

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Luci-IVSdelta-Luci in construct Con5



<400>  5

catctgccag gtatcagggt gagtctatgg gacccttgat gttttctttc cccttctttt       60



ctatggttaa gttcatgtca taggaagggg agaagtaaca gggtacacat attgaccaaa      120



tcagggtaat tttgcatttg taattttaaa aaatgctttc ttcttttaat atactttttt      180



gtttatctta tttctaatac tttccctaat ctctttcttt cagggcaata atgatacaat      240



gtatcatgcc tctttgcacc attctaaaga ataacagtga taatttctgg gttaaggcaa      300



tagcaatatt tctgcatata aatatttctg catataaatt gtaactgatg taagaggttt      360



catattgcta atagcagcta caatccagct accattctgc ttttatttta tggttgggat      420



aaggctggat tattctgagt ccaagctagg cccttttgct aatcatgttc atacccttta      480



cttctatgac tgtagcaagg atatgggctc actgagact                             519





<210>  6

<211>  521

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Luci-IVSdelta-Luci in construct Con6



<400>  6

tccatctgcc aggtatcagg gtgagtctat gggacccttg atgttttctt tccccttctt       60



ttctatggtt aagttcatgt cataggaagg ggagaagtaa cagggtacac atattgacca      120



aatcagggta attttgcatt tgtaatttta aaaaatgctt tcttctttta atatactttt      180



ttgtttatct tatttctaat actttcccta atctctttct ttcagggcaa taatgataca      240



atgtatcatg cctctttgca ccattctaaa gaataacagt gataatttct gggttaaggc      300



aatagcaata tttctgcata taaatatttc tgcatataaa ttgtaactga tgtaagaggt      360



ttcatattgc taatagcagc tacaatccag ctaccattct gcttttattt tatggttggg      420



ataaggctgg attattctga gtccaagcta ggcccttttg ctaatcatgt tcataccgtg      480



actgtgtgta tgcacagcaa ggatatgggc tcactgagac t                          521





<210>  7

<211>  518

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Luci-IVSdelta-Luci in construct Con7



<400>  7

atctgccagg tatcagggtg agtctatggg acccttgatg ttttctttcc ccttcttttc       60



tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata ttgaccaaat      120



cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata tacttttttg      180



tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa tgatacaatg      240



tatcatgcct ctttgcacca ttctaaagaa taacagtgat aatttctggg ttaaggcaat      300



agcaatattt ctgcatataa atatttctgc atataaattg taactgatgt aagaggtttc      360



atattgctaa tagcagctac aatccagcta ccattctgct tttattttat ggttgggata      420



aggctggatt attctgagtc caagctaggc ccttttgcta atcatgttca taccattgtg      480



atcgcagcca atagcaagga tatgggctca ctgagact                              518





<210>  8

<211>  85

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR exon 2 with flanking intronic sequence



<400>  8

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaccac       60



aacctcttca gtagaaggta atgtg                                             85





<210>  9

<211>  33

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Theophylline aptamer



<400>  9

ggcgatacca gccgaaaggc ccttggcagc gtc                                    33





<210>  10

<211>  69

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Xpt-guanine aptamer



<400>  10

cactcatata atcgcgtgga tatggcacgc aagtttctac cgggcaccgt aaatgtccga       60



ctatgggtg                                                               69





<210>  11

<211>  63

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Ydhl-Guanine aptamer



<400>  11

ttgtataacc tcaataatat ggtttgaggg tgtctaccag gaaccgtaaa atcctgacta       60



caa                                                                     63





<210>  12

<211>  63

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Ydhl-Adenine aptamer



<400>  12

ttgtataacc tcaataatat ggtttgaggg tgtctaccag gaaccgtaaa atcctgatta       60



caa                                                                     63





<210>  13

<211>  63

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  addA-Guanine aptamer



<400>  13

tcatataatc ctaatgatat ggtttgggag tttctaccaa gagccttaaa ctcttgacta       60



tga                                                                     63





<210>  14

<211>  63

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  addA-Adenine aptamer



<400>  14

tcatataatc ctaatgatat ggtttgggag tttctaccaa gagccttaaa ctcttgatta       60



tga                                                                     63





<210>  15

<211>  617

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17 riboswitch       

<400>  15

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      240



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      300



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      360



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      420



caatagcaat atttctgcat ataaatattt ctgcatataa attgtaactg atgtaagagg      480



tttcatattg ctaatagcag ctacaatcca gctaccattc tgcttttatt ttatggttgg      540



gataaggctg gattattctg agtccaagct aggccctttt gctaatcatg ttcatacctc      600



ttatcttcct cccacag                                                     617





<210>  16

<211>  557

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-1



<400>  16

gtgagtctat gggacccttg atgttttctt tccctgctca aatcagggta attttgcatt       60



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      120



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      180



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      240



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      300



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      360



caatagcaat atttctgcat ataaatattt ctgcatataa attgtaactg atgtaagagg      420



tttcatattg ctaatagcag ctacaatcca gctaccattc tgcttttatt ttatggttgg      480



gataaggctg gattattctg agtccaagct aggccctttt gctaatcatg ttcatacctc      540



ttatcttcct cccacag                                                     557





<210>  17

<211>  457

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-2



<400>  17

gtgagtctat gggacccttg atgttttctt tccctgctct ttcagggcaa taatgataca       60



atgtatcatg ccgagtaacg ctgtttctct aacttgtagg aatgaattca gatatttcca      120



gagaatgaaa aaaaaatctt cagtagaagg taatgtataa tcgcgtggat atggcacgca      180



agtttctacc gggcaccgta aatgtccgac tacattacgc accattctaa agaataacag      240



tgataatttc tgggttaagg caatagcaat atttctgcat ataaatattt ctgcatataa      300



attgtaactg atgtaagagg tttcatattg ctaatagcag ctacaatcca gctaccattc      360



tgcttttatt ttatggttgg gataaggctg gattattctg agtccaagct aggccctttt      420



gctaatcatg ttcatacctc ttatcttcct cccacag                               457





<210>  18

<211>  582

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-3



<400>  18

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



gctcaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata      120



cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag ggcaataatg      180



atacaatgta tcatgccgag taacgctgtt tctctaactt gtaggaatga attcagatat      240



ttccagagaa tgaaaaaaaa atcttcagta gaaggtaatg tataatcgcg tggatatggc      300



acgcaagttt ctaccgggca ccgtaaatgt ccgactacat tacgcaccat tctaaagaat      360



aacagtgata atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca      420



tataaattgt aactgatgta agaggtttca tattgctaat agcagctaca atccagctac      480



cattctgctt ttattttatg gttgggataa ggctggatta ttctgagtcc aagctaggcc      540



cttttgctaa tcatgttcat acctcttatc ttcctcccac ag                         582





<210>  19

<211>  482

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-4



<400>  19

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



gctctttcag ggcaataatg atacaatgta tcatgccgag taacgctgtt tctctaactt      120



gtaggaatga attcagatat ttccagagaa tgaaaaaaaa atcttcagta gaaggtaatg      180



tataatcgcg tggatatggc acgcaagttt ctaccgggca ccgtaaatgt ccgactacat      240



tacgcaccat tctaaagaat aacagtgata atttctgggt taaggcaata gcaatatttc      300



tgcatataaa tatttctgca tataaattgt aactgatgta agaggtttca tattgctaat      360



agcagctaca atccagctac cattctgctt ttattttatg gttgggataa ggctggatta      420



ttctgagtcc aagctaggcc cttttgctaa tcatgttcat acctcttatc ttcctcccac      480



ag                                                                     482





<210>  20

<211>  611

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-5



<400>  20

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtactg ctcaaatcag ggtaattttg catttgtaat      120



tttaaaaaat gctttcttct tttaatatac ttttttgttt atcttatttc taatactttc      180



cctaatctct ttctttcagg gcaataatga tacaatgtat catgccgagt aacgctgttt      240



ctctaacttg taggaatgaa ttcagatatt tccagagaat gaaaaaaaaa tcttcagtag      300



aaggtaatgt ataatcgcgt ggatatggca cgcaagtttc taccgggcac cgtaaatgtc      360



cgactacatt acgcaccatt ctaaagaata acagtgataa tttctgggtt aaggcaatag      420



caatatttct gcatataaat atttctgcat ataaattgta actgatgtaa gaggtttcat      480



attgctaata gcagctacaa tccagctacc attctgcttt tattttatgg ttgggataag      540



gctggattat tctgagtcca agctaggccc ttttgctaat catgttcata cctcttatct      600



tcctcccaca g                                                           611





<210>  21

<211>  511

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-6



<400>  21

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtactg ctctttcagg gcaataatga tacaatgtat      120



catgccgagt aacgctgttt ctctaacttg taggaatgaa ttcagatatt tccagagaat      180



gaaaaaaaaa tcttcagtag aaggtaatgt ataatcgcgt ggatatggca cgcaagtttc      240



taccgggcac cgtaaatgtc cgactacatt acgcaccatt ctaaagaata acagtgataa      300



tttctgggtt aaggcaatag caatatttct gcatataaat atttctgcat ataaattgta      360



actgatgtaa gaggtttcat attgctaata gcagctacaa tccagctacc attctgcttt      420



tattttatgg ttgggataag gctggattat tctgagtcca agctaggccc ttttgctaat      480



catgttcata cctcttatct tcctcccaca g                                     511





<210>  22

<211>  592

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-7



<400>  22

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagt gctcaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc      120



ttttaatata cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag      180



ggcaataatg atacaatgta tcatgccgag taacgctgtt tctctaactt gtaggaatga      240



attcagatat ttccagagaa tgaaaaaaaa atcttcagta gaaggtaatg tataatcgcg      300



tggatatggc acgcaagttt ctaccgggca ccgtaaatgt ccgactacat tacgcaccat      360



tctaaagaat aacagtgata atttctgggt taaggcaata gcaatatttc tgcatataaa      420



tatttctgca tataaattgt aactgatgta agaggtttca tattgctaat agcagctaca      480



atccagctac cattctgctt ttattttatg gttgggataa ggctggatta ttctgagtcc      540



aagctaggcc cttttgctaa tcatgttcat acctcttatc ttcctcccac ag              592





<210>  23

<211>  492

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-8



<400>  23

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagt gctctttcag ggcaataatg atacaatgta tcatgccgag taacgctgtt      120



tctctaactt gtaggaatga attcagatat ttccagagaa tgaaaaaaaa atcttcagta      180



gaaggtaatg tataatcgcg tggatatggc acgcaagttt ctaccgggca ccgtaaatgt      240



ccgactacat tacgcaccat tctaaagaat aacagtgata atttctgggt taaggcaata      300



gcaatatttc tgcatataaa tatttctgca tataaattgt aactgatgta agaggtttca      360



tattgctaat agcagctaca atccagctac cattctgctt ttattttatg gttgggataa      420



ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcatgttcat acctcttatc      480



ttcctcccac ag                                                          492





<210>  24

<211>  502

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-9



<400>  24

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      240



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      300



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      360



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      420



caatagctgc tgctggatta ttctgagtcc aagctaggcc cttttgctaa tcatgttcat      480



acctcttatc ttcctcccac ag                                               502





<210>  25

<211>  587

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-10



<400>  25

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      240



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      300



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      360



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      420



caatagcaat atttctgcat ataaatattt ctgcatataa attgtaactg atgtaagagg      480



tttcatattg ctaatagcag ctacaatcca gctgctgctg gattattctg agtccaagct      540



aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacag                    587





<210>  26

<211>  572

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-11



<400>  26

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      240



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      300



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      360



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      420



caatagctgc tgaggtttca tattgctaat agcagctaca atccagctac cattctgctt      480



ttattttatg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa      540



tcatgttcat acctcttatc ttcctcccac ag                                    572





<210>  27

<211>  537

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-13



<400>  27

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      240



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      300



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      360



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      420



caatagctgc tctaccattc tgcttttatt ttatggttgg gataaggctg gattattctg      480



agtccaagct aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacag         537





<210>  28

<211>  552

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-IR-15



<400>  28

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      240



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      300



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      360



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      420



caatagctgc tgcagctaca atccagctac cattctgctt ttattttatg gttgggataa      480



ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcatgttcat acctcttatc      540



ttcctcccac ag                                                          552





<210>  29

<211>  442

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-1



<400>  29

gtgagtctat gggacccttg atgttttctt tccctgctca aatcagggta attttgcatt       60



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      120



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      180



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      240



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      300



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      360



caatagctgc tgctggatta ttctgagtcc aagctaggcc cttttgctaa tcatgttcat      420



acctcttatc ttcctcccac ag                                               442





<210>  30

<211>  527

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-2



<400>  30

gtgagtctat gggacccttg atgttttctt tccctgctca aatcagggta attttgcatt       60



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      120



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      180



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      240



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      300



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      360



caatagcaat atttctgcat ataaatattt ctgcatataa attgtaactg atgtaagagg      420



tttcatattg ctaatagcag ctacaatcca gctgctgctg gattattctg agtccaagct      480



aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacag                    527





<210>  31

<211>  512

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-3



<400>  31

gtgagtctat gggacccttg atgttttctt tccctgctca aatcagggta attttgcatt       60



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      120



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      180



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      240



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      300



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      360



caatagctgc tgaggtttca tattgctaat agcagctaca atccagctac cattctgctt      420



ttattttatg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa      480



tcatgttcat acctcttatc ttcctcccac ag                                    512





<210>  32

<211>  477

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-4



<400>  32

gtgagtctat gggacccttg atgttttctt tccctgctca aatcagggta attttgcatt       60



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      120



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      180



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      240



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      300



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      360



caatagctgc tctaccattc tgcttttatt ttatggttgg gataaggctg gattattctg      420



agtccaagct aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacag         477





<210>  33

<211>  492

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-5



<400>  33

gtgagtctat gggacccttg atgttttctt tccctgctca aatcagggta attttgcatt       60



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      120



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      180



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      240



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      300



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      360



caatagctgc tgcagctaca atccagctac cattctgctt ttattttatg gttgggataa      420



ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcatgttcat acctcttatc      480



ttcctcccac ag                                                          492





<210>  34

<211>  467

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-6



<400>  34

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



gctcaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata      120



cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag ggcaataatg      180



atacaatgta tcatgccgag taacgctgtt tctctaactt gtaggaatga attcagatat      240



ttccagagaa tgaaaaaaaa atcttcagta gaaggtaatg tataatcgcg tggatatggc      300



acgcaagttt ctaccgggca ccgtaaatgt ccgactacat tacgcaccat tctaaagaat      360



aacagtgata atttctgggt taaggcaata gctgctgctg gattattctg agtccaagct      420



aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacag                    467





<210>  35

<211>  552

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-7



<400>  35

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



gctcaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata      120



cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag ggcaataatg      180



atacaatgta tcatgccgag taacgctgtt tctctaactt gtaggaatga attcagatat      240



ttccagagaa tgaaaaaaaa atcttcagta gaaggtaatg tataatcgcg tggatatggc      300



acgcaagttt ctaccgggca ccgtaaatgt ccgactacat tacgcaccat tctaaagaat      360



aacagtgata atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca      420



tataaattgt aactgatgta agaggtttca tattgctaat agcagctaca atccagctgc      480



tgctggatta ttctgagtcc aagctaggcc cttttgctaa tcatgttcat acctcttatc      540



ttcctcccac ag                                                          552





<210>  36

<211>  537

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-8



<400>  36

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



gctcaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata      120



cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag ggcaataatg      180



atacaatgta tcatgccgag taacgctgtt tctctaactt gtaggaatga attcagatat      240



ttccagagaa tgaaaaaaaa atcttcagta gaaggtaatg tataatcgcg tggatatggc      300



acgcaagttt ctaccgggca ccgtaaatgt ccgactacat tacgcaccat tctaaagaat      360



aacagtgata atttctgggt taaggcaata gctgctgagg tttcatattg ctaatagcag      420



ctacaatcca gctaccattc tgcttttatt ttatggttgg gataaggctg gattattctg      480



agtccaagct aggccctttt gctaatcatg ttcatacctc ttatcttcct cccacag         537





<210>  37

<211>  502

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-9



<400>  37

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



gctcaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata      120



cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag ggcaataatg      180



atacaatgta tcatgccgag taacgctgtt tctctaactt gtaggaatga attcagatat      240



ttccagagaa tgaaaaaaaa atcttcagta gaaggtaatg tataatcgcg tggatatggc      300



acgcaagttt ctaccgggca ccgtaaatgt ccgactacat tacgcaccat tctaaagaat      360



aacagtgata atttctgggt taaggcaata gctgctctac cattctgctt ttattttatg      420



gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa tcatgttcat      480



acctcttatc ttcctcccac ag                                               502





<210>  38

<211>  517

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-10



<400>  38

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



gctcaaatca gggtaatttt gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata      120



cttttttgtt tatcttattt ctaatacttt ccctaatctc tttctttcag ggcaataatg      180



atacaatgta tcatgccgag taacgctgtt tctctaactt gtaggaatga attcagatat      240



ttccagagaa tgaaaaaaaa atcttcagta gaaggtaatg tataatcgcg tggatatggc      300



acgcaagttt ctaccgggca ccgtaaatgt ccgactacat tacgcaccat tctaaagaat      360



aacagtgata atttctgggt taaggcaata gctgctgcag ctacaatcca gctaccattc      420



tgcttttatt ttatggttgg gataaggctg gattattctg agtccaagct aggccctttt      480



gctaatcatg ttcatacctc ttatcttcct cccacag                               517





<210>  39

<211>  342

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-11



<400>  39

gtgagtctat gggacccttg atgttttctt tccctgctct ttcagggcaa taatgataca       60



atgtatcatg ccgagtaacg ctgtttctct aacttgtagg aatgaattca gatatttcca      120



gagaatgaaa aaaaaatctt cagtagaagg taatgtataa tcgcgtggat atggcacgca      180



agtttctacc gggcaccgta aatgtccgac tacattacgc accattctaa agaataacag      240



tgataatttc tgggttaagg caatagctgc tgctggatta ttctgagtcc aagctaggcc      300



cttttgctaa tcatgttcat acctcttatc ttcctcccac ag                         342





<210>  40

<211>  377

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-12



<400>  40

gtgagtctat gggacccttg atgttttctt tccctgctct ttcagggcaa taatgataca       60



atgtatcatg ccgagtaacg ctgtttctct aacttgtagg aatgaattca gatatttcca      120



gagaatgaaa aaaaaatctt cagtagaagg taatgtataa tcgcgtggat atggcacgca      180



agtttctacc gggcaccgta aatgtccgac tacattacgc accattctaa agaataacag      240



tgataatttc tgggttaagg caatagctgc tctaccattc tgcttttatt ttatggttgg      300



gataaggctg gattattctg agtccaagct aggccctttt gctaatcatg ttcatacctc      360



ttatcttcct cccacag                                                     377





<210>  41

<211>  367

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-13



<400>  41

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



gctctttcag ggcaataatg atacaatgta tcatgccgag taacgctgtt tctctaactt      120



gtaggaatga attcagatat ttccagagaa tgaaaaaaaa atcttcagta gaaggtaatg      180



tataatcgcg tggatatggc acgcaagttt ctaccgggca ccgtaaatgt ccgactacat      240



tacgcaccat tctaaagaat aacagtgata atttctgggt taaggcaata gctgctgctg      300



gattattctg agtccaagct aggccctttt gctaatcatg ttcatacctc ttatcttcct      360



cccacag                                                                367





<210>  42

<211>  402

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-14



<400>  42

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



gctctttcag ggcaataatg atacaatgta tcatgccgag taacgctgtt tctctaactt      120



gtaggaatga attcagatat ttccagagaa tgaaaaaaaa atcttcagta gaaggtaatg      180



tataatcgcg tggatatggc acgcaagttt ctaccgggca ccgtaaatgt ccgactacat      240



tacgcaccat tctaaagaat aacagtgata atttctgggt taaggcaata gctgctctac      300



cattctgctt ttattttatg gttgggataa ggctggatta ttctgagtcc aagctaggcc      360



cttttgctaa tcatgttcat acctcttatc ttcctcccac ag                         402





<210>  43

<211>  396

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-15



<400>  43

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtactg ctctttcagg gcaataatga tacaatgtat      120



catgccgagt aacgctgttt ctctaacttg taggaatgaa ttcagatatt tccagagaat      180



gaaaaaaaaa tcttcagtag aaggtaatgt ataatcgcgt ggatatggca cgcaagtttc      240



taccgggcac cgtaaatgtc cgactacatt acgcaccatt ctaaagaata acagtgataa      300



tttctgggtt aaggcaatag ctgctgctgg attattctga gtccaagcta ggcccttttg      360



ctaatcatgt tcatacctct tatcttcctc ccacag                                396





<210>  44

<211>  431

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-2IR-16



<400>  44

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtactg ctctttcagg gcaataatga tacaatgtat      120



catgccgagt aacgctgttt ctctaacttg taggaatgaa ttcagatatt tccagagaat      180



gaaaaaaaaa tcttcagtag aaggtaatgt ataatcgcgt ggatatggca cgcaagtttc      240



taccgggcac cgtaaatgtc cgactacatt acgcaccatt ctaaagaata acagtgataa      300



tttctgggtt aaggcaatag ctgctctacc attctgcttt tattttatgg ttgggataag      360



gctggattat tctgagtcca agctaggccc ttttgctaat catgttcata cctcttatct      420



tcctcccaca g                                                           431





<210>  45

<211>  617

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G17-3ssC-1



<400>  45

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      240



ctgtttctct aacttccccg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      300



cagtagaagg taatgtataa tcgcgtggat atggcacgca agtttctacc gggcaccgta      360



aatgtccgac tacattacgc accattctaa agaataacag tgataatttc tgggttaagg      420



caatagcaat atttctgcat ataaatattt ctgcatataa attgtaactg atgtaagagg      480



tttcatattg ctaatagcag ctacaatcca gctaccattc tgcttttatt ttatggttgg      540



gataaggctg gattattctg agtccaagct aggccctttt gctaatcatg ttcatacctc      600



ttatcttcct cccacag                                                     617





<210>  46

<211>  621

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G15 riboswitch



<400>  46

gtgagtctat gggacccttg atgttttctt tccccttctt ttctatggtt aagttcatgt       60



cataggaagg ggagaagtaa cagggtacac atattgacca aatcagggta attttgcatt      120



tgtaatttta aaaaatgctt tcttctttta atatactttt ttgtttatct tatttctaat      180



actttcccta atctctttct ttcagggcaa taatgataca atgtatcatg ccgagtaacg      240



ctgtttctct aacttgtagg aatgaattca gatatttcca gagaatgaaa aaaaaatctt      300



cagtagaagg taatgtgtat aatcgcgtgg atatggcacg caagtttcta ccgggcaccg      360



taaatgtccg actacacatt acgcaccatt ctaaagaata acagtgataa tttctgggtt      420



aaggcaatag caatatttct gcatataaat atttctgcat ataaattgta actgatgtaa      480



gaggtttcat attgctaata gcagctacaa tccagctacc attctgcttt tattttatgg      540



ttgggataag gctggattat tctgagtcca agctaggccc ttttgctaat catgttcata      600



cctcttatct tcctcccaca g                                                621





<210>  47

<211>  85

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR WildType 5' single-strand



<400>  47

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaccac       60



aacctcttca gtagaaggta atgtg                                             85





<210>  48

<211>  85

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR 5' single-strandC



<400>  48

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaccac       60



aacctcttca gtagaagccc ctgtg                                             85





<210>  49

<211>  85

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR-Con1 5' single-strand



<400>  49

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaccac       60



aacctcttca gtagagggtg agttg                                             85





<210>  50

<211>  85

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR-Con4 5' single-strand



<400>  50

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaccac       60



aacctcttca gtaggaggtg tggtg                                             85





<210>  51

<211>  85

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR WildType mtSRp40



<400>  51

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaaaaa       60



aaaatcttca gtagaaggta atgtg                                             85





<210>  52

<211>  85

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR WildType strongSC35



<400>  52

gagtaacgct gtttctctaa cttgtaggaa tggcccctga tatttccaga gaatgaccac       60



aacctcttca gtagaaggta atgtg                                             85





<210>  53

<211>  85

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR WildType SC35hnRNPA1



<400>  53

gagtaacgct gtttctctaa cttgtaggaa tgtagggaga tatttccaga gaatgaccac       60



aacctcttca gtagaaggta atgtg                                             85





<210>  54

<211>  106

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR-Con1 5' single-strand HP15



<400>  54

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaccac       60



aacctcttca gtagagggtg agttggcgaa agccaactca ccctct                     106





<210>  55

<211>  106

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR-Con1 5' single-strand HP15x



<400>  55

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaccac       60



aacctcttca gtagagggtg agttggcgaa aaacagcata aagtat                     106





<210>  56

<211>  106

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR WildType mtSRp40 HP15



<400>  56

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaaaaa       60



aaaatcttca gtagaaggta atgtggcgaa agccacatta ccttct                     106





<210>  57

<211>  106

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  DHFR WildType mtSRp40 HP15X



<400>  57

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaaaaa       60



aaaatcttca gtagaaggta atgtggcgaa aaacagaact gagtat                     106





<210>  58

<211>  84

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Mutant DHFR-e2 (mtDHFR)



<400>  58

gagtaacgct gtttctctaa cttgtaggaa tgaattcaga tatttccaga gaatgaaaaa       60



aaaatcttca gtagaaggta atgt                                              84





<210>  59

<211>  77

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Camk2d-e16



<400>  59

gagtaacgct gtttctctaa cttgtagtga gccccaaact actgtaatcc acaaccctga       60



cggaaacaag gtaatgt                                                      77





<210>  60

<211>  83

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  Camk2d-e17



<400>  60

gagtaacgct gtttctctaa cttgtaggag tcaactgaga gctcaaacac caccattgag       60



gatgaagacg tgaaaggtaa tgt                                               83





<210>  61

<211>  85

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  mutWT1-e5



<400>  61

gagtaacgct gtttctctaa cttgtagagt tgctgctgag agctccagct cagtgaaatg       60



gacagaaggg cagagcaagt aatgt                                             85





<210>  62

<211>  151

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  SIRT1-e6



<400>  62

tgtggtgtgt tcaagaaaca gaaatacttc tttaataaag catatatatg ttgtttgttt       60



ttaggttcct ttgcaacagc atcttgcctg atttgtaaat acaaagttga ctgtgaagct      120



gtacgaggag atatttttaa tcaggtaatg t                                     151





<210>  63

<211>  114

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  ENEEE synthetic exon



<400>  63

gagtaacgct gtttctctaa cttgtagaca atcctcgaac caaacaacca aacaaccaaa       60



caatcctcga accaaacaat cctcgaacca aacaatcctc gaaccaagta atgt            114





<210>  64

<211>  1639

<212>  DNA

<213>  Artificial Sequence



<220>

<223>  xpt-G15-double



<400>  64

gccaagaggt tccatctgcc aggtatcagg gtgagtctat gggacccttg atgttttctt       60



tccccttctt ttctatggtt aagttcatgt cataggaagg ggagaagtaa cagggtacac      120



atattgacca aatcagggta attttgcatt tgtaatttta aaaaatgctt tcttctttta      180



atatactttt ttgtttatct tatttctaat actttcccta atctctttct ttcagggcaa      240



taatgataca atgtatcatg ccgagtaacg ctgtttctct aacttgtagg aatgaattca      300



gatatttcca gagaatgaaa aaaaaatctt cagtagaagg taatgtgtat aatcgcgtgg      360



atatggcacg caagtttcta ccgggcaccg taaatgtccg actacacatt acgcaccatt      420



ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct gcatataaat      480



atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata gcagctacaa      540



tccagctacc attctgcttt tattttatgg ttgggataag gctggattat tctgagtcca      600



agctaggccc ttttgctaat catgttcata cctcttatct tcctcccaca gcaaggatat      660



gggctcactg agactacatc agctattctg attacacccg agggggatga taaaccgggc      720



gcggtcggta aagttgttcc attttttgaa gcgaaggttg tggatctgga taccgggaaa      780



acgctgggcg ttaatcaaag aggcgaactg tgtgtgagag gtcctatgat tatgtccggt      840



tatgtaaaca atccggaagc gaccaacgcc ttgattgaca aggatggatg gctacattct      900



ggagacatag cttactggga cgaagacgaa cacttcttca tcgttgaccg cctgaagtct      960



ctgattaagt acaaagggtg agtctatggg acccttgatg ttttctttcc ccttcttttc     1020



tatggttaag ttcatgtcat aggaagggga gaagtaacag ggtacacata ttgaccaaat     1080



cagggtaatt ttgcatttgt aattttaaaa aatgctttct tcttttaata tacttttttg     1140



tttatcttat ttctaatact ttccctaatc tctttctttc agggcaataa tgatacaatg     1200



tatcatgccg agtaacgctg tttctctaac ttgtaggaat gaattcagat atttccagag     1260



aatgaaaaaa aaatcttcag tagaaggtaa tgtgtataat cgcgtggata tggcacgcaa     1320



gtttctaccg ggcaccgtaa atgtccgact acacattacg caccattcta aagaataaca     1380



gtgataattt ctgggttaag gcaatagcaa tatttctgca tataaatatt tctgcatata     1440



aattgtaact gatgtaagag gtttcatatt gctaatagca gctacaatcc agctaccatt     1500



ctgcttttat tttatggttg ggataaggct ggattattct gagtccaagc taggcccttt     1560



tgctaatcat gttcatacct cttatcttcc tcccacagct atcaggtggc tcccgctgaa     1620



ttggaatcca tcttgctcc                                                  1639





