                         SEQUENCE LISTING

<110>  Ablynx N.V.
 
<120>  Cysteine linked dimers -2

<130>  P15-003-PCT-1

<150>  US62/112,218
<151>  2015-02-05

<150>  US62/269,434
<151>  2015-12-18

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  1
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  1

Cys 
1   


<210>  2
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  2

Gly Cys 
1       


<210>  3
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  3

Gly Gly Cys 
1           


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  4

Gly Gly Gly Cys 
1               


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  5

Gly Gly Gly Gly Cys 
1               5   


<210>  6
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  6

Ala Cys 
1       


<210>  7
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  7

Ala Ala Cys 
1           


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  8

Ala Ala Ala Cys 
1               


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  9

Ala Ala Ala Ala Cys 
1               5   


<210>  10
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  10

Cys Gly 
1       


<210>  11
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  11

Gly Cys Gly 
1           


<210>  12
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  12

Gly Gly Cys Gly 
1               


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  13

Gly Gly Gly Cys Gly 
1               5   


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  14

Gly Gly Gly Gly Cys Gly 
1               5       


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  15

Gly Gly Gly Gly Cys Gly Gly Gly Gly 
1               5                   


<210>  16
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  16

Ala Ala Ala 
1           


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  17

Gly Gly Gly Gly Ser 
1               5   


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  18

Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  20

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  21
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  21

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  22

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  23
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  24
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  24

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  25
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210>  26
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  26

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser 
        35  


<210>  27
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  27

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
                165                 170                 175     


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Cys 
            260         


<210>  28
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobdy

<400>  28

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                165                 170                 175     


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Cys 
            260                 265                 270     


<210>  29
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  29

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
                165                 170                 175     


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
                245                 250                 255     


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Cys 
        


<210>  30
<211>  406
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  30

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
                165                 170                 175     


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285             


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
    290                 295                 300                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
305                 310                 315                 320 


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                325                 330                 335     


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
            340                 345                 350         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
        355                 360                 365             


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
    370                 375                 380                 


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
385                 390                 395                 400 


Val Ser Ser Gly Gly Cys 
                405     


<210>  31
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  31

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
                165                 170                 175     


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
                245                 250                 255     


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    290                 295                 300                 


Pro Gly Asn Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
305                 310                 315                 320 


Ser Ser Phe Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
                325                 330                 335     


Glu Trp Val Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala 
            340                 345                 350         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr 
        355                 360                 365             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val 
    370                 375                 380                 


Tyr Tyr Cys Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr 
385                 390                 395                 400 


Leu Val Thr Val Ser Ser Gly Gly Cys 
                405                 


<210>  32
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  33
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  33

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  34
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  35
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  36
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  37
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Lys 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  38
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  39
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala 
        115     


<210>  40
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala 
        115         


<210>  41
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ala Ala 
        115             


<210>  42
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly 
        115     


<210>  43
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly 
        115         


<210>  44
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Asn 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Gly Ser Gly Ser Asp Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Gly Gly Ser Leu Ser Arg Ser Ser Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly 
        115             


<210>  45
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  45

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  46
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework1

<400>  46

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg 
            20                  25                  30  


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cdr1

<400>  47

Ser Tyr Gly Met Gly 
1               5   


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework2

<400>  48

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
1               5                   10                  


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cdr2

<400>  49

Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  50
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework3

<400>  50

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cdr3

<400>  51

Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr 
1               5                   10                  15  


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework4

<400>  52

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  53
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9G8

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Val Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr 
            100                 105                 110         


Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  54
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework1

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser 
            20                  25                  30  


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cdr1

<400>  55

Ser Tyr Ala Met Gly 
1               5   


<210>  56
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework2

<400>  56

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Val 
1               5                   10                  


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cdr2

<400>  57

Ala Ile Asn Trp Ser Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  58
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework3

<400>  58

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  59
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cdr3

<400>  59

Gly Tyr Gln Ile Asn Ser Gly Asn Tyr Asn Phe Lys Asp Tyr Glu Tyr 
1               5                   10                  15      


Asp Tyr 
        


<210>  60
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  framework4

<400>  60

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  61
<211>  1210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hEGFR

<400>  61

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  62
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Gly Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp 
        35                  40                  45              


Val Ala Ala Ile Ala Ser Gly Gly Ser Ile Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser His Pro Pro Thr Leu Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser 
                165                 170                 175     


Gly Ile Ser Ser Ser Lys Arg Asn Met Gly Trp Tyr Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Gln Arg Glu Ser Val Ala Thr Ile Ser Ser Gly Gly Asn Lys 
        195                 200                 205             


Asp Tyr Thr Asp Ala Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Thr 
    210                 215                 220                 


Thr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Val Tyr Tyr Cys Lys Ile Glu Ala Gly Thr Gly Trp Ala Thr 
                245                 250                 255     


Arg Arg Gly Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser 
    


<210>  63
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Gly Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp 
        35                  40                  45              


Val Ala Ala Ile Ala Ser Gly Gly Ser Ile Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser His Pro Pro Thr Leu Pro Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                165                 170                 175     


Gly Arg Ala Phe Ser Arg Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Gly Trp Gly Pro Ser Lys 
        195                 200                 205             


Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    210                 215                 220                 


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Ser Cys Ala Ala Lys Phe Val Asn Thr Asp Ser 
                245                 250                 255     


Thr Trp Ser Arg Ser Glu Met Tyr Thr Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser 
        275         


<210>  64
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Ser Ser Ser Lys Arg 
            20                  25                  30          


Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Ser Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Asn Lys Asp Tyr Thr Asp Ala Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Arg Asp Thr Thr Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ile Glu Ala Gly Thr Gly Trp Ala Thr Arg Arg Gly Tyr Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Gly Asn Val Met Gly 
            180                 185                 190         


Trp Tyr Arg Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Ala 
        195                 200                 205             


Ile Ala Ser Gly Gly Ser Ile Tyr Tyr Arg Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ser His 
                245                 250                 255     


Pro Pro Thr Leu Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            260                 265                 270         


Ser 
    


<210>  65
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Gly 
            180                 185                 190         


Asn Val Met Gly Trp Tyr Arg Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        195                 200                 205             


Trp Val Ala Ala Ile Ala Ser Gly Gly Ser Ile Tyr Tyr Arg Asp Ser 
    210                 215                 220                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Asn Ser His Pro Pro Thr Leu Pro Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser 
        275         


<210>  66
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Arg Ala Leu Asn Met Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Thr Ser Ser Ser Gly Gly Ser Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Arg Cys 
                85                  90                  95      


Ala Ala Ser Pro Tyr Val Ser Thr Pro Thr Met Asn Ile Leu Glu Glu 
            100                 105                 110         


Tyr Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Ser Ser Ser Lys 
            180                 185                 190         


Arg Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Ser 
        195                 200                 205             


Val Ala Thr Ile Ser Ser Gly Gly Asn Lys Asp Tyr Thr Asp Ala Val 
    210                 215                 220                 


Lys Asp Arg Phe Thr Ile Ser Arg Asp Thr Thr Lys Asn Thr Val Tyr 
225                 230                 235                 240 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                245                 250                 255     


Lys Ile Glu Ala Gly Thr Gly Trp Ala Thr Arg Arg Gly Tyr Thr Tyr 
            260                 265                 270         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280             


<210>  67
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Arg Ala Leu Asn Met Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Thr Ser Ser Ser Gly Gly Ser Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Arg Cys 
                85                  90                  95      


Ala Ala Ser Pro Tyr Val Ser Thr Pro Thr Met Asn Ile Leu Glu Glu 
            100                 105                 110         


Tyr Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
                165                 170                 175     


Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg 
            180                 185                 190         


Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
        195                 200                 205             


Val Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser 
    210                 215                 220                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser 
                245                 250                 255     


Cys Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu 
            260                 265                 270         


Met Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280                 285         


<210>  68
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Ser Ser Ser Lys Arg 
            20                  25                  30          


Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Ser Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Asn Lys Asp Tyr Thr Asp Ala Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Arg Asp Thr Thr Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ile Glu Ala Gly Thr Gly Trp Ala Thr Arg Arg Gly Tyr Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Thr Thr Ser Gly Arg Ala Leu Asn Met Tyr Val Met Gly 
            180                 185                 190         


Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Phe Val Ala Ala Thr 
        195                 200                 205             


Ser Ser Ser Gly Gly Ser Thr Ser Tyr Pro Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Arg Cys Ala Ala Ser 
                245                 250                 255     


Pro Tyr Val Ser Thr Pro Thr Met Asn Ile Leu Glu Glu Tyr Arg Tyr 
            260                 265                 270         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280             


<210>  69
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
                165                 170                 175     


Gly Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Arg Ala Leu Asn Met 
            180                 185                 190         


Tyr Val Met Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Phe 
        195                 200                 205             


Val Ala Ala Thr Ser Ser Ser Gly Gly Ser Thr Ser Tyr Pro Asp Ser 
    210                 215                 220                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
225                 230                 235                 240 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Arg 
                245                 250                 255     


Cys Ala Ala Ser Pro Tyr Val Ser Thr Pro Thr Met Asn Ile Leu Glu 
            260                 265                 270         


Glu Tyr Arg Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280                 285         


<210>  70
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr 
            100                 105                 110         


Asp Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    130                 135                 140                 


Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser 
145                 150                 155                 160 


Gly Arg Ala Phe Ser Arg Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro 
                165                 170                 175     


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Gly Trp Gly Pro Ser Lys 
            180                 185                 190         


Thr Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        195                 200                 205             


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Thr Leu Lys Pro Glu 
    210                 215                 220                 


Asp Thr Ala Val Tyr Ser Cys Ala Ala Lys Phe Val Asn Thr Asp Ser 
225                 230                 235                 240 


Thr Trp Ser Arg Ser Glu Met Tyr Thr Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  71
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    130                 135                 140                 


Gly Ser Val Gln Pro Gly Gly Ser Leu Thr Leu Ser Cys Gly Thr Ser 
145                 150                 155                 160 


Gly Arg Thr Phe Asn Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ala Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr 
            180                 185                 190         


Tyr Thr Gln Tyr Ala Asp Ser Val Lys Ser Arg Phe Thr Ile Ser Arg 
        195                 200                 205             


Asp Asn Ala Lys Asn Thr Val Tyr Leu Glu Met Asn Ser Leu Lys Pro 
    210                 215                 220                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Tyr Asn Ser Asn 
225                 230                 235                 240 


Pro Ala Arg Trp Asp Gly Tyr Asp Phe Arg Gly Gln Gly Thr Gln Val 
                245                 250                 255     


Thr Val Ser Ser 
            260 


<210>  72
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Gly Ser Tyr Trp 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
        195                 200                 205             


Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Val Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys Ala 
                245                 250                 255     


Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280         


<210>  73
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
145                 150                 155                 160 


Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser 
                165                 170                 175     


Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Gly Ser Tyr Trp 
            180                 185                 190         


Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Ala Val Ala 
        195                 200                 205             


Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val Lys 
    210                 215                 220                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
225                 230                 235                 240 


Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys Ala 
                245                 250                 255     


Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280         


<210>  74
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
            180                 185                 190         


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
        195                 200                 205             


Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
                245                 250                 255     


Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280         


<210>  75
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val 
145                 150                 155                 160 


Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly Ser Leu 
                165                 170                 175     


Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr Gly Met 
            180                 185                 190         


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Gly 
        195                 200                 205             


Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val Lys Gly 
    210                 215                 220                 


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln 
225                 230                 235                 240 


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
                245                 250                 255     


Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280         


<210>  76
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Ser Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Leu Arg Trp Ser Ser Ser Asn Ile Asp Tyr Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ser Ile Ser Gly Asp Tyr Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Ser Thr Arg Trp Gly Val Met Glu Ser Asp Thr 
            100                 105                 110         


Glu Tyr Thr Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro 
                165                 170                 175     


Gly Gly Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn 
            180                 185                 190         


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        195                 200                 205             


Ala Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala 
    210                 215                 220                 


Asp Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
225                 230                 235                 240 


Thr Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp 
            260                 265                 270         


Gly Tyr Asp Phe Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280                 285         


<210>  77
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Ser Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Leu Arg Trp Ser Ser Gly Asn Ile Asp Tyr Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ser Ile Ser Gly Asp Tyr Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Ser Thr Arg Trp Gly Val Met Glu Ser Asp Thr 
            100                 105                 110         


Glu Tyr Thr Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro 
                165                 170                 175     


Gly Gly Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn 
            180                 185                 190         


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        195                 200                 205             


Ala Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala 
    210                 215                 220                 


Asp Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
225                 230                 235                 240 


Thr Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp 
            260                 265                 270         


Gly Tyr Asp Phe Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280                 285         


<210>  78
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  78

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Pro Arg Leu Val 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Glu Ile Ile Leu Ser Lys Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Val Asn Ala Lys Asn Thr Ile Thr 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gly Arg Gln Asn Trp Ser Gly Ser Pro Ala Arg Thr Asn 
            100                 105                 110         


Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro 
                165                 170                 175     


Gly Gly Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn 
            180                 185                 190         


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        195                 200                 205             


Ala Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala 
    210                 215                 220                 


Asp Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
225                 230                 235                 240 


Thr Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp 
            260                 265                 270         


Gly Tyr Asp Phe Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280                 285         


<210>  79
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Pro Ser Ile Ile 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Glu Ile Ile Leu Ser Lys Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Ala Asn Ala Lys Asn Thr Ile Thr 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Gln Asn Trp Ser Gly Asn Pro Thr Arg Thr Asn 
            100                 105                 110         


Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
145                 150                 155                 160 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro 
                165                 170                 175     


Gly Gly Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn 
            180                 185                 190         


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        195                 200                 205             


Ala Ala Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala 
    210                 215                 220                 


Asp Ser Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
225                 230                 235                 240 


Thr Val Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
                245                 250                 255     


Tyr Tyr Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp 
            260                 265                 270         


Gly Tyr Asp Phe Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280                 285         


<210>  80
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Thr Asp 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala His Arg Thr Ser Gly Ile Ser Thr Val Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gly Met Lys Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys 
                85                  90                  95      


Ala Ala Gly Ser Asp Ala Ser Gly Gly Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
145                 150                 155                 160 


Ser Gly Gly Gly Ser Val Gln Pro Gly Gly Ser Leu Thr Leu Ser Cys 
                165                 170                 175     


Gly Thr Ser Gly Arg Thr Phe Asn Val Met Gly Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Val Arg Trp Ser Ser Thr 
        195                 200                 205             


Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser Val Lys Ser Arg Phe Thr 
    210                 215                 220                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Glu Met Asn Ser 
225                 230                 235                 240 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Thr Tyr 
                245                 250                 255     


Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr Asp Phe Arg Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser 
        275                 


<210>  81
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ile Gly Glu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Tyr Tyr Thr Ala Tyr Val Ala Ala Ala Asp Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val Met 
            180                 185                 190         


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        195                 200                 205             


Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser 
    210                 215                 220                 


Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
225                 230                 235                 240 


Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                245                 250                 255     


Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr 
            260                 265                 270         


Asp Phe Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        275                 280                 285 


<210>  82
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  82

Cys Ala 
1       


<210>  83
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  83

Gly Cys Ala 
1           


<210>  84
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  84

Gly Gly Cys Ala 
1               


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  85

Gly Gly Gly Cys Ala 
1               5   


<210>  86
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  86

Gly Gly Gly Gly Cys Ala 
1               5       


<210>  87
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  87

Ala Cys Ala 
1           


<210>  88
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  88

Ala Ala Cys Ala 
1               


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  89

Ala Ala Ala Cys Ala 
1               5   


<210>  90
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  90

Ala Ala Ala Ala Cys Ala 
1               5       


<210>  91
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  91

Cys Gly Ala 
1           


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  92

Gly Cys Gly Ala 
1               


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  93

Gly Gly Cys Gly Ala 
1               5   


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  94

Gly Gly Gly Cys Gly Ala 
1               5       


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  95

Gly Gly Gly Gly Cys Gly Ala 
1               5           


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  c-terminal extension

<400>  96

Gly Gly Gly Gly Cys Gly Gly Gly Gly Ala 
1               5                   10  


<210>  97
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Gly Asn 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp 
        35                  40                  45              


Val Ala Ala Ile Ala Ser Gly Gly Ser Ile Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser His Pro Pro Thr Leu Pro Tyr Trp Gly Leu Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  98
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Arg Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Gly Trp Gly Pro Ser Lys Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Lys Phe Val Asn Thr Asp Ser Thr Trp Ser Arg Ser Glu Met 
            100                 105                 110         


Tyr Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  99
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Ile Ser Ser Ser Lys Arg 
            20                  25                  30          


Asn Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Ser Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Asn Lys Asp Tyr Thr Asp Ala Val Lys 
    50                  55                  60                  


Asp Arg Phe Thr Ile Ser Arg Asp Thr Thr Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Lys 
                85                  90                  95      


Ile Glu Ala Gly Thr Gly Trp Ala Thr Arg Arg Gly Tyr Thr Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  100
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Arg Ala Leu Asn Met Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Asn Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Thr Ser Ser Ser Gly Gly Ser Thr Ser Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ala Tyr Arg Cys 
                85                  90                  95      


Ala Ala Ser Pro Tyr Val Ser Thr Pro Thr Met Asn Ile Leu Glu Glu 
            100                 105                 110         


Tyr Arg Tyr Trp Gly Leu Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  101
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Gly Thr Ser Gly Arg Thr Phe Asn Val Met 
            20                  25                  30          


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        35                  40                  45              


Val Arg Trp Ser Ser Thr Gly Ile Tyr Tyr Thr Gln Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
65                  70                  75                  80  


Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Ala Asp Thr Tyr Asn Ser Asn Pro Ala Arg Trp Asp Gly Tyr 
            100                 105                 110         


Asp Phe Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  102
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  102

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Arg Thr Ser Arg Ser Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Arg Gly Asp Ser Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Ala Gly Ser Ala Trp Tyr Gly Thr Leu Tyr Glu Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  103
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  104
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Gly Ser Tyr 
            20                  25                  30          


Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Ala Val 
        35                  40                  45              


Ala Ala Ile Asn Arg Gly Gly Gly Tyr Thr Val Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Gly Val Leu Gly Gly Leu His Glu Asp Trp Phe Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  105
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Ser Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Leu Arg Trp Ser Ser Ser Asn Ile Asp Tyr Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ser Ile Ser Gly Asp Tyr Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Ser Thr Arg Trp Gly Val Met Glu Ser Asp Thr 
            100                 105                 110         


Glu Tyr Thr Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  106
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  106

Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Ser Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Leu Arg Trp Ser Ser Gly Asn Ile Asp Tyr Thr Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ser Ile Ser Gly Asp Tyr Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Ser Thr Arg Trp Gly Val Met Glu Ser Asp Thr 
            100                 105                 110         


Glu Tyr Thr Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  107
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Pro Arg Leu Val 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Glu Ile Ile Leu Ser Lys Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Val Asn Ala Lys Asn Thr Ile Thr 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Gly Arg Gln Asn Trp Ser Gly Ser Pro Ala Arg Thr Asn 
            100                 105                 110         


Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  108
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Pro Ser Ile Ile 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Glu Ile Ile Leu Ser Lys Gly Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Ala Asn Ala Lys Asn Thr Ile Thr 
65                  70                  75                  80  


Met Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala Arg Gln Asn Trp Ser Gly Asn Pro Thr Arg Thr Asn 
            100                 105                 110         


Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  109
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Arg Thr Phe Ser Thr Asp 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala His Arg Thr Ser Gly Ile Ser Thr Val Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gly Met Lys Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys 
                85                  90                  95      


Ala Ala Gly Ser Asp Ala Ser Gly Gly Tyr Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  110
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  nanobody

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Asp Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ile Gly Glu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Tyr Tyr Thr Ala Tyr Val Ala Ala Ala Asp Glu Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


