SEQUENCE LISTING



<110>  CELLECTIS

<120>  PRIMARY HEMATOPOIETIC CELLS GENETICALLY ENGINEERED BY SLOW RELEASE OF NUCLEIC ACIDS USING NANOPARTICLES

<130>  P81500506PCT00

<150>  PA201570072
<151>  2015-02-06	

<160>  9

<170>  PatentIn version 3.5


<210>  1

<211>  239
<212>  PRT
<213>  aequoria victoria

<220>
<223>  GFP protein

<400>  1
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 

<210>  2

<211>  233
<212>  PRT
<213>  artificial sequence

<220>
<223>  BFP protein

<400>  2
Met Ser Glu Leu Ile Lys Glu Asn Met His Met Lys Leu Tyr Met Glu 
1               5                   10                  15      


Gly Thr Val Asp Asn His His Phe Lys Cys Thr Ser Glu Gly Glu Gly 
            20                  25                  30          


Lys Pro Tyr Glu Gly Thr Gln Thr Met Arg Ile Lys Val Val Glu Gly 
        35                  40                  45              


Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser Phe Leu Tyr 
    50                  55                  60                  


Gly Ser Lys Thr Phe Ile Asn His Thr Gln Gly Ile Pro Asp Phe Phe 
65                  70                  75                  80  


Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Thr Thr Tyr 
                85                  90                  95      


Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp 
            100                 105                 110         


Gly Cys Leu Ile Tyr Asn Val Lys Ile Arg Gly Val Asn Phe Thr Ser 
        115                 120                 125             


Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp Glu Ala Phe Thr 
    130                 135                 140                 


Glu Thr Leu Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Asn Asp Met 
145                 150                 155                 160 


Ala Leu Lys Leu Val Gly Gly Ser His Leu Ile Ala Asn Ile Lys Thr 
                165                 170                 175     


Thr Tyr Arg Ser Lys Lys Pro Ala Lys Asn Leu Lys Met Pro Gly Val 
            180                 185                 190         


Tyr Tyr Val Asp Tyr Arg Leu Glu Arg Ile Lys Glu Ala Asn Asn Glu 
        195                 200                 205             


Thr Tyr Val Glu Gln His Glu Val Ala Val Ala Arg Tyr Cys Asp Leu 
    210                 215                 220                 


Pro Ser Lys Leu Gly His Lys Leu Asn 
225                 230             


<210>  3

<211>  936
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN TRAC 1 LEFT

<400>  3
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Tyr Pro Tyr Asp 
1               5                   10                  15      


Val Pro Asp Tyr Ala Ile Asp Ile Ala Asp Leu Arg Thr Leu Gly Tyr 
            20                  25                  30          


Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys Val Arg Ser Thr Val 
        35                  40                  45              


Ala Gln His His Glu Ala Leu Val Gly His Gly Phe Thr His Ala His 
    50                  55                  60                  


Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu Gly Thr Val Ala Val 
65                  70                  75                  80  


Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu Ala Thr His Glu Ala 
                85                  90                  95      


Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala Arg Ala Leu Glu Ala 
            100                 105                 110         


Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro Pro Leu Gln Leu Asp 
        115                 120                 125             


Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly Gly Val Thr Ala Val 
    130                 135                 140                 


Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr Gly Ala Pro Leu Asn 
145                 150                 155                 160 


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
                165                 170                 175     


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            180                 185                 190         


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
        195                 200                 205             


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    210                 215                 220                 


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
225                 230                 235                 240 


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                245                 250                 255     


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            260                 265                 270         


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        275                 280                 285             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    290                 295                 300                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
305                 310                 315                 320 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                325                 330                 335     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            340                 345                 350         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        355                 360                 365             


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
    370                 375                 380                 


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
385                 390                 395                 400 


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                405                 410                 415     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            420                 425                 430         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        435                 440                 445             


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
    450                 455                 460                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
465                 470                 475                 480 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                485                 490                 495     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            500                 505                 510         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
        515                 520                 525             


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    530                 535                 540                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
545                 550                 555                 560 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                565                 570                 575     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 
            580                 585                 590         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
        595                 600                 605             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    610                 615                 620                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
625                 630                 635                 640 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
                645                 650                 655     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            660                 665                 670         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        675                 680                 685             


Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala 
    690                 695                 700                 


Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala Cys Leu Gly Gly Arg 
705                 710                 715                 720 


Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly Asp Pro Ile Ser Arg 
                725                 730                 735     


Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
            740                 745                 750         


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
        755                 760                 765             


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
    770                 775                 780                 


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
785                 790                 795                 800 


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
                805                 810                 815     


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
            820                 825                 830         


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
        835                 840                 845             


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
    850                 855                 860                 


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
865                 870                 875                 880 


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
                885                 890                 895     


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
            900                 905                 910         


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
        915                 920                 925             


Gly Glu Ile Asn Phe Ala Ala Asp 
    930                 935     


<210>  4

<211>  942
<212>  PRT
<213>  artificial sequence

<220>
<223>  TALEN TRAC 1 RIGHT

<400>  4
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Lys Glu Thr Ala 
1               5                   10                  15      


Ala Ala Lys Phe Glu Arg Gln His Met Asp Ser Ile Asp Ile Ala Asp 
            20                  25                  30          


Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro 
        35                  40                  45              


Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His 
    50                  55                  60                  


Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala 
65                  70                  75                  80  


Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro 
                85                  90                  95      


Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly 
            100                 105                 110         


Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly 
        115                 120                 125             


Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg 
    130                 135                 140                 


Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu 
145                 150                 155                 160 


Thr Gly Ala Pro Leu Asn Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
                165                 170                 175     


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            180                 185                 190         


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
        195                 200                 205             


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
    210                 215                 220                 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
225                 230                 235                 240 


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
                245                 250                 255     


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
            260                 265                 270         


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
        275                 280                 285             


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
    290                 295                 300                 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
305                 310                 315                 320 


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
                325                 330                 335     


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
            340                 345                 350         


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
        355                 360                 365             


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
    370                 375                 380                 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
385                 390                 395                 400 


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
                405                 410                 415     


Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
            420                 425                 430         


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
        435                 440                 445             


Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
    450                 455                 460                 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
465                 470                 475                 480 


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
                485                 490                 495     


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
            500                 505                 510         


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
        515                 520                 525             


Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
    530                 535                 540                 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
545                 550                 555                 560 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
                565                 570                 575     


Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
            580                 585                 590         


Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly 
        595                 600                 605             


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
    610                 615                 620                 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
625                 630                 635                 640 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
                645                 650                 655     


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
            660                 665                 670         


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
        675                 680                 685             


Gly Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg 
    690                 695                 700                 


Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu 
705                 710                 715                 720 


Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu 
                725                 730                 735     


Gly Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu 
            740                 745                 750         


Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr 
        755                 760                 765             


Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu 
    770                 775                 780                 


Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly 
785                 790                 795                 800 


Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val 
                805                 810                 815     


Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser 
            820                 825                 830         


Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr 
        835                 840                 845             


Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp 
    850                 855                 860                 


Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val 
865                 870                 875                 880 


Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn 
                885                 890                 895     


His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu 
            900                 905                 910         


Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val 
        915                 920                 925             


Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
    930                 935                 940         




<210>  5

<211>  7665
<212>  DNA
<213>  artificial sequence

<220>
<223>  pSel EF1- GFP

<400>  5
gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt     60
caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa    120
ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt    180
gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt    240
tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt    300
ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg    360
tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga    420
atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa    480
gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga    540
caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa    600
ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca    660
ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta    720
ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac    780
ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc    840
gtggttctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag    900
ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga    960
taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt   1020
agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata   1080
atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag   1140
aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa   1200
caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt   1260
ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt ctagtgtagc   1320
cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa   1380
tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa   1440
gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc   1500
ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa   1560
gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa   1620
caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg   1680
ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc   1740
tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg   1800
ctcacatggt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg   1860
agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg   1920
aagcggagag cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg   1980
cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt   2040
gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt   2100
gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgacc atgattacgc   2160
caagcgcgtc aattaaccct cactaaaggg aacaaaagct gttaattaag agatggagtt   2220
ttgctcttgt tgcccaggct ggagtgcaat ggtgcatctt ggctcactac aagcctctgc   2280
ctcccaggtt caagtgattc tcctgcctca gcccctccgg caaacctctg tttcctcctc   2340
aaaaggcagg aggtcggaaa gaataaacaa tgagagtcac attaaaaaca caaaatccta   2400
cggaaatact gaagaatgag tctcagcact aaggaaaagc ctccagcagc tcctgctttc   2460
tgagggtgaa ggatagacgc tgtggctctg catgactcac tagcactcta tcacggccat   2520
attctggcag ggtcagtggc tccaactaac atttgtttgg tactttacag tttattaaat   2580
agatgtttat atggagaagc tctcatttct ttctcagaag agcctggcta ggaaggtgga   2640
tgaggcacca tattcatttt gcaggtgaaa ttcctgagat gtaaggagct gctgtgactt   2700
gctcaaggcc ttatatcgag taaacggtag cgctggggct tagacgcagg tgttctgatt   2760
tatagttcaa aacctctatc aatgagagag caatctcctg gtaatgtgat agatttccca   2820
acttaatgcc aacataccat aaacctccca ttctgctaat gcccagccta agttggggag   2880
accactccag attccaagat gtacagtttg ctttgctggg cctttttccc atgcctgcct   2940
ttactctgcc agagttatat tgctggggtt ttgaagaaga tcctattaaa taaaagaata   3000
agcagtatta ttaagtagcc ctgcatttca ggtttccttg agtggcaggc caggcctggc   3060
cgtgaacgtt cactgaaatc atggcctctt ggccaagatt gatagcttgt gcctgtccct   3120
gagtcccagt ccatcacgag cagctggttt ctaagatgct atttcccgta taaagcatga   3180
gaccgtgact tgccagcccc acagagcccc gcccttgtcc atcactggca tctggactcc   3240
agcctgggtt ggggcaaaga gggaaatgag atcatgtcct aaccctgatc ctcttgtccc   3300
acagatatcc agtaccccta cgacgtgccc gactacgcct ccggtgaggg cagaggaagt   3360
cttctaacat gcggtgacgt ggaggagaat ccgggccccg gatccgtgag caagggcgag   3420
gagctgttca ccggggtggt gcccatcctg gtcgagctgg acggcgacgt aaacggccac   3480
aagttcagcg tgtccggcga gggcgagggc gatgccacct acggcaagct gaccctgaag   3540
ttcatctgca ccaccggcaa gctgcccgtg ccctggccca ccctcgtgac caccctgacc   3600
tacggcgtgc agtgcttcag ccgctacccc gaccacatga agcagcacga cttcttcaag   3660
tccgccatgc ccgaaggcta cgtccaggag cgcaccatct tcttcaagga cgacggcaac   3720
tacaagaccc gcgccgaggt gaagttcgag ggcgacaccc tggtgaaccg catcgagctg   3780
aagggcatcg acttcaagga ggacggcaac atcctggggc acaagctgga gtacaactac   3840
aacagccaca acgtctatat catggccgac aagcagaaga acggcatcaa ggtgaacttc   3900
aagatccgcc acaacatcga ggacggcagc gtgcagctcg ccgaccacta ccagcagaac   3960
acccccatcg gcgacggccc cgtgctgctg cccgacaacc actacctgag cacccagtcc   4020
gccctgagca aagaccccaa cgagaagcgc gatcacatgg tcctgctgga gttcgtgacc   4080
gccgccggga tcactctcgg catggacgag ctgtacaagt aaagcggccg cgtcgagtct   4140
agagggcccg tttaaacccg ctgatcagcc tcgactgtgc cttctagttg ccagccatct   4200
gttgtttgcc cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt   4260
tcctaataaa atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg   4320
ggtggggtgg ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg   4380
gatgcggtgg gctctatgac tagtggcgaa ttcccgtgta ccagctgaga gactctaaat   4440
ccagtgacaa gtctgtctgc ctattcaccg attttgattc tcaaacaaat gtgtcacaaa   4500
gtaaggattc tgatgtgtat atcacagaca aaactgtgct agacatgagg tctatggact   4560
tcaagagcaa cagtgctgtg gcctggagca acaaatctga ctttgcatgt gcaaacgcct   4620
tcaacaacag cattattcca gaagacacct tcttccccag cccaggtaag ggcagctttg   4680
gtgccttcgc aggctgtttc cttgcttcag gaatggccag gttctgccca gagctctggt   4740
caatgatgtc taaaactcct ctgattggtg gtctcggcct tatccattgc caccaaaacc   4800
ctctttttac taagaaacag tgagccttgt tctggcagtc cagagaatga cacgggaaaa   4860
aagcagatga agagaaggtg gcaggagagg gcacgtggcc cagcctcagt ctctccaact   4920
gagttcctgc ctgcctgcct ttgctcagac tgtttgcccc ttactgctct tctaggcctc   4980
attctaagcc ccttctccaa gttgcctctc cttatttctc cctgtctgcc aaaaaatctt   5040
tcccagctca ctaagtcagt ctcacgcagt cactcattaa cccaccaatc actgattgtg   5100
ccggcacatg aatgcaccag gtgttgaagt ggaggaatta aaaagtcaga tgaggggtgt   5160
gcccagagga agcaccattc tagttggggg agcccatctg tcagctggga aaagtccaaa   5220
taacttcaga ttggaatgtg ttttaactca gggttgagaa aacagccacc ttcaggacaa   5280
aagtcaggga agggctctct gaagaaatgc tacttgaaga taccagccct accaagggca   5340
gggagaggac cctatagagg cctgggacag gagctcaatg agaaaggaga agagcagcag   5400
gcatgagttg aatggcgcgc cggatctgcg atcgctccgg tgcccgtcag tgggcagagc   5460
gcacatcgcc cacagtcccc gagaagttgg ggggaggggt cggcaattga acgggtgcct   5520
agagaaggtg gcgcggggta aactgggaaa gtgatgtcgt gtactggctc cgcctttttc   5580
ccgagggtgg gggagaaccg tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca   5640
acgggtttgc cgccagaaca cagctgaagc ttcgaggggc tcgcatctct ccttcacgcg   5700
cccgccgccc tacctgaggc cgccatccac gccggttgag tcgcgttctg ccgcctcccg   5760
cctgtggtgc ctcctgaact gcgtccgccg tctaggtaag tttaaagctc aggtcgagac   5820
cgggcctttg tccggcgctc ccttggagcc tacctagact cagccggctc tccacgcttt   5880
gcctgaccct gcttgctcaa ctctacgtct ttgtttcgtt ttctgttctg cgccgttaca   5940
gatccaagct gtgaccggcg cctacctgag atcaccggcg tgtcgaaaac cgccaccatg   6000
agcgagctga ttaaggagaa catgcacatg aagctgtaca tggagggcac cgtggacaac   6060
catcacttca agtgcacatc cgagggcgaa ggcaagccct acgagggcac ccagaccatg   6120
agaatcaagg tggtcgaggg cggccctctc cccttcgcct tcgacatcct ggctactagc   6180
ttcctctacg gcagcaagac cttcatcaac cacacccagg gcatccccga cttcttcaag   6240
cagtccttcc ctgagggctt cacatgggag agagtcacca catacgaaga cgggggcgtg   6300
ctgaccgcta cccaggacac cagcctccag gacggctgcc tcatctacaa cgtcaagatc   6360
agaggggtga acttcacatc caacggccct gtgatgcaga agaaaacact cggctgggag   6420
gccttcaccg agacgctgta ccccgctgac ggcggcctgg aaggcagaaa cgacatggcc   6480
ctgaagctcg tgggcgggag ccatctgatc gcaaacatca agaccacata tagatccaag   6540
aaacccgcta agaacctcaa gatgcctggc gtctactatg tggactacag actggaaaga   6600
atcaaggagg ccaacaacga gacctacgtc gagcagcacg aggtggcagt ggccagatac   6660
tgcgacctcc ctagcaaact ggggcacaag cttaattaac ccggggagcg gccgcggagc   6720
tccaggaatt ctgcagatat ccatcacact ggcggccgct cgagcgctag ctggccagac   6780
atgataagat acattgatga gtttggacaa accacaacta gaatgcagtg aaaaaaatgc   6840
tttatttgtg aaatttgtga tgctattgct ttatttgtaa ccattataag ctgcaataaa   6900
caagttaaca acaacaattg cattcatttt atgtttcagg ttcaggggga ggtgtgggag   6960
gttttttaaa gcaagtaaaa cctctacaaa tgtggtatgg aaggcgcgcc caattcgccc   7020
tatagtgagt cgtattacgt cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga   7080
aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg   7140
taatagcgaa gaggcccgca ccgaaacgcc cttcccaaca gttgcgcagc ctgaatggcg   7200
aatgggagcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt   7260
gaccgctaca cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct   7320
cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg   7380
atttagtgct ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttggcctgt   7440
agtgggccat agccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt   7500
aatagtggac tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt   7560
gatttataag ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa   7620
aaatttaacg cgaattttaa caaaatatta acgcttacaa tttag                   7665


210>  6

<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Target TCRa

<400>  6
gtcagggttc tggatatctg                                                 20


<210>  7

<211>  20
<212>  DNA
<213>  artificial sequence

<220>
<223>  Target CD52

<400>  7
ggaggctgat ggtgagtagg                                                 20



<210>  8
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  8

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS from nucleoplasmin

<400>  9

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      




