                         SEQUENCE LISTING

<110>  Crucell Holland B.V.
 
<120>  Human neutralizing antibodies binding to influenza neuraminidase

<130>  0249 EP P00 PRI

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-040 HCDR1

<400>  1

Gly Tyr Thr Phe Thr Asn Tyr Tyr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-040 HCDR2

<400>  2

Ile Asn Pro Leu His Gly Gly Thr 
1               5               


<210>  3
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-040 HCDR3

<400>  3

Val Lys Glu Arg Asp Thr Thr Met Ala Thr Asp Tyr Tyr Gly Arg Ser 
1               5                   10                  15      


Gly Cys Phe Asp Tyr 
            20      


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-041 HCDR1

<400>  4

Gly Tyr Thr Phe Thr Asn Tyr Tyr 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-041 HCDR2

<400>  5

Ile Asn Pro Ser Ser Gly Gly Thr 
1               5               


<210>  6
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-041 HCDR3

<400>  6

Ala Arg Ala Gly Glu Gly Lys Ser Arg Phe Gly Glu Gly Lys Leu Arg 
1               5                   10                  15      


Tyr Phe Tyr Tyr Gly Met Asp Val 
            20                  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-042 HCDR1

<400>  7

Gly Asp Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-042 HCDR2

<400>  8

Ile Ile Pro Ile Phe Gly Thr Ala 
1               5               


<210>  9
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-042 HCDR3

<400>  9

Ala Arg Gly Pro Asp Asn His Ser Asp Arg Tyr Phe Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-044 HCDR1

<400>  10

Gly Gly Ala Phe Arg Thr Ser Val 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-044 HCDR2

<400>  11

Ile Ile Pro Thr Leu Asp Thr Ala 
1               5               


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-044 HCDR3

<400>  12

Ala Thr Asp Tyr Gly Gly Asn Ser Asp Arg Leu Gly Ser Tyr Ser Phe 
1               5                   10                  15      


Ala Phe Asp Val 
            20  


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-040 LCDR1

<400>  13

Gln Ser Val Arg Ser Tyr 
1               5       


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-040 LCDR2

<400>  14

Asp Ala Ser 
1           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-040 LCDR3

<400>  15

Gln Gln Arg Ser Asn Trp Pro Ile Thr 
1               5                   


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-041 LCDR1

<400>  16

Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr 
1               5                   10      


<210>  17
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-041 LCDR2

<400>  17

Leu Gly Ser 
1           


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-041 LCDR3

<400>  18

Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-042 LCDR1

<400>  19

Gln Ser Leu Leu His Ser Thr Gly Asn Asn Tyr 
1               5                   10      


<210>  20
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-042 LCDR2

<400>  20

Leu Gly Ser 
1           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-042 LCDR3

<400>  21

Met Gln Ala Leu Gln Thr Pro Arg Thr 
1               5                   


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-044 LCDR1

<400>  22

Ser Ser Asn Ile Gly Ser Asn Thr 
1               5               


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-044 LCDR2

<400>  23

Ser Asn Asn 
1           


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-044 LCDR3

<400>  24

Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val 
1               5                   10      


<210>  25
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-040 HC VARIABLE REGION

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asn Pro Leu His Gly Gly Thr Gly Phe Ala Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Leu Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Asp 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Val Lys Glu Arg Asp Thr Thr Met Ala Thr Asp Tyr Tyr Gly Arg Ser 
            100                 105                 110         


Gly Cys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-040 LC VARIABLE REGION

<400>  26

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-041 HC VARIABLE REGION

<400>  27

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Leu His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Ser Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Ser Gly Gly Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Phe 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Gly Glu Gly Lys Ser Arg Phe Gly Glu Gly Lys Leu Arg 
            100                 105                 110         


Tyr Phe Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  28
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-041 LC VARIABLE REGION

<400>  28

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  29
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-042 HC VARIABLE REGION

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Asp Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Asp Asn His Ser Asp Arg Tyr Phe Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-042 LC VARIABLE REGION

<400>  30

Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Thr Gly Asn Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110         


<210>  31
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-044 HC VARIABLE REGION

<400>  31

Glu Val Gln Leu Val Gln Ser Gly Ser Glu Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Thr Val Lys Val Ser Cys Lys Gly Ser Gly Gly Ala Phe Arg Thr Ser 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Arg Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Leu Asp Thr Ala Asn His Ala Gln Glu Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Ile Thr Ala Asp Glu Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Tyr Gly Gly Asn Ser Asp Arg Leu Gly Ser Tyr Ser Phe 
            100                 105                 110         


Ala Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  32
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12-044 LC VARIABLE REGION

<400>  32

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Trp Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


