                         SEQUENCE LISTING

<110>  Universitaet Zuerich
       Universitaet Basel
 
<120>  Use of HLA-B27 homodimers for cancer treatment

<130>  uz217wo

<160>  176   

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala 
            20                  


<210>  2
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala 
                85                  90  


<210>  3
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly Pro Asp 
1               5                   10                  15      


Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly Lys Asp 
            20                  25                  30          


Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr 
        35                  40                  45              


Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val Ala Glu 
    50                  55                  60                  


Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu Arg Arg 
65                  70                  75                  80  


Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala 
                85                  90          


<210>  4
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Pro Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu 
1               5                   10                  15      


Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr 
            20                  25                  30          


Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu 
        35                  40                  45              


Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala 
    50                  55                  60                  


Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln 
65                  70                  75                  80  


His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser 
                85                  90                  95      


Gln Ser Thr Val Pro Ile Val 
            100             


<210>  5
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val Val Val Ile Gly Ala 
1               5                   10                  15      


Val Val Ala Ala Val Met Cys Arg Arg Lys Ser Ser Gly Gly Lys Gly 
            20                  25                  30          


Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser Ala Gln Gly Ser Asp 
        35                  40                  45              


Val Ser Leu Thr Ala 
    50              


<210>  6
<211>  280
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(90)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (91)..(182)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (183)..(280)
<223>  alpha 3

<400>  6

Gly Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr 
65                  70                  75                  80  


Leu Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Asn Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro Ser Ser Gln Ser 
        275                 280 


<210>  7
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  7

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Tyr Arg Glu Asn Leu Arg Thr Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  8
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  8

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asn Leu Arg Ile Ala Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  9
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  9

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  10
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  Signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(119)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (120)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  10

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu His Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  11
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(119)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (120)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  11

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  12
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  12

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  13
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  13

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  14
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  14

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  15
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  15

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  16
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  16

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  17
<211>  206
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<400>  17

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala 
        195                 200                 205     


<210>  18
<211>  298
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(298)
<223>  alpha 3

<400>  18

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp 
    290                 295             


<210>  19
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  19

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  20
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  20

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  21
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  21

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  22
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  22

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  23
<211>  296
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(10)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (11)..(100)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (101)..(192)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (193)..(295)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (296)..(296)
<223>  transmembrabe

<400>  23

Gly Ala Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg 
1               5                   10                  15      


Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe 
            20                  25                  30          


Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser 
        35                  40                  45              


Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln 
    50                  55                  60                  


Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys 
65                  70                  75                  80  


Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn 
                85                  90                  95      


Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp 
            100                 105                 110         


Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr 
        115                 120                 125             


Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr 
    130                 135                 140                 


Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala 
145                 150                 155                 160 


Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu 
                165                 170                 175     


Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala 
            180                 185                 190         


Asp Pro Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu 
        195                 200                 205             


Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr 
    210                 215                 220                 


Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu 
225                 230                 235                 240 


Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala 
                245                 250                 255     


Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln 
            260                 265                 270         


His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser 
        275                 280                 285             


Gln Ser Thr Val Pro Ile Val Gly 
    290                 295     


<210>  24
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  24

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  25
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  25

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  26
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  26

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  27
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  27

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  28
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  28

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  29
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  29

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  30
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  30

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  31
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  31

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  32
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  32

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  33
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  33

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  34
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  34

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  35
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  35

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  36
<211>  325
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(325)
<223>  transmembrane and cytoplasmic tail

<400>  36

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala 
                325 


<210>  37
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  37

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  38
<211>  298
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(298)
<223>  alpha 3

<400>  38

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp 
    290                 295             


<210>  39
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (182)..(273)
<223>  alpha 3

<400>  39

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp 
    


<210>  40
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  40

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  41
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  41

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  42
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  42

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  43
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  43

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asn Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  44
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (182)..(273)
<223>  alpha 3

<400>  44

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Ser 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly His 
            100                 105                 110         


Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp 
    


<210>  45
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  45

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Ser 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly His 
            100                 105                 110         


Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  46
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  46

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Ser 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly His 
            100                 105                 110         


Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  47
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  47

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  48
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  48

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln His Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  49
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  49

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  50
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (182)..(273)
<223>  alpha 3

<400>  50

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Met Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Gly Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp 
    


<210>  51
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  51

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Gln Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  52
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  52

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  53
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (182)..(273)
<223>  alpha 3

<400>  53

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Cys 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Gly Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp 
    


<210>  54
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  54

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Ala Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  55
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (182)..(273)
<223>  alpha 3

<400>  55

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu His Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Gly Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp 
    


<210>  56
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  56

Ser His Ser Met Arg Tyr Phe His Thr Ala Met Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  57
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  57

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  58
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  58

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  59
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  59

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Arg Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  60
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  60

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asn Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  61
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  61

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asn Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  62
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  62

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Cys Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu His Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  63
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  63

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Val Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  64
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  64

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Gly Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  65
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  65

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Gly Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  66
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  66

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Trp Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  67
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  67

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu His Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  68
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  68

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Lys Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  69
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  69

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  70
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  70

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  71
<211>  341
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(341)
<223>  transmembrane and cytoplasmic tail

<400>  71

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Thr Asn Thr Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly 
            340     


<210>  72
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  72

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Cys Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  73
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  73

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Arg Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  74
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  74

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Cys Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  75
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  75

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Arg Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  76
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  76

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Ser Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  77
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  77

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asn Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Gln Arg Lys Leu Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  78
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  78

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Val Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  79
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  79

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln Arg 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


Asp Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Asp Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Leu Cys Val Glu Ser Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  80
<211>  206
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<400>  80

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Thr Leu Gln Arg Ala 
        195                 200                 205     


<210>  81
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  81

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Asn Thr Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  82
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  82

Met Arg Val Thr Glu Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  83
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  83

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln Thr 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly His 
            100                 105                 110         


Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  84
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  84

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Tyr Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  85
<211>  206
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<400>  85

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Trp Gln Thr Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala 
        195                 200                 205     


<210>  86
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  86

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  87
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  87

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Thr Asn Thr Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  88
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  88

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Phe Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  89
<211>  206
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<400>  89

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Ser Lys Thr Asn Thr Gln 
                85                  90                  95      


Thr Tyr Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala 
        195                 200                 205     


<210>  90
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  90

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln Arg 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  91
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (182)..(273)
<223>  alpha 3

<400>  91

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly His 
            100                 105                 110         


Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Gly Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp 
    


<210>  92
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  92

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Arg 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  93
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  93

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr Gln 
    50                  55                  60                  


Ile Phe Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  94
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  94

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asn Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Ser Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  95
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  95

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Trp Arg Ala Tyr Leu Glu Gly Leu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  96
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  96

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn Leu 
65                  70                  75                  80  


Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  97
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  97

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly His 
            100                 105                 110         


Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  98
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  98

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Thr Cys Val Glu Trp Leu Arg Arg His Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  99
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  99

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  100
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  100

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln Arg 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  101
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  101

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  102
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  102

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  103
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  103

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn Leu 
65                  70                  75                  80  


Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Ser 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly His 
            100                 105                 110         


Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  104
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  104

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Ser 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly His 
            100                 105                 110         


Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  105
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  105

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asn Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  106
<211>  302
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (182)..(284)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (285)..(302)
<223>  transmembrane and cytoplasmic tail

<400>  106

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Gln Arg 
    130                 135                 140                 


Lys Leu Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Asp 
                165                 170                 175     


Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp Glu Pro Ser Ser Gln Ser Thr Val Pro Ile Val Gly Ile Val Ala 
        275                 280                 285             


Gly Leu Ala Val Leu Ala Val Val Val Ile Gly Ala Val Val 
    290                 295                 300         


<210>  107
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  107

Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  108
<211>  309
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(19)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (20)..(109)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (110)..(201)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (202)..(304)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (305)..(309)
<223>  transmembrane

<400>  108

Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala Val Ala Leu Thr Glu 
1               5                   10                  15      


Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser 
            20                  25                  30          


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp 
        35                  40                  45              


Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu 
    50                  55                  60                  


Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp 
65                  70                  75                  80  


Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp 
                85                  90                  95      


Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His 
            100                 105                 110         


Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu 
        115                 120                 125             


Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala 
    130                 135                 140                 


Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln 
145                 150                 155                 160 


Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg 
                165                 170                 175     


Ala Tyr Leu Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu 
            180                 185                 190         


Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val 
        195                 200                 205             


Thr His His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala 
    210                 215                 220                 


Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly 
225                 230                 235                 240 


Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly 
                245                 250                 255     


Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu 
            260                 265                 270         


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro 
        275                 280                 285             


Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser Thr Val Pro Ile Val 
    290                 295                 300                 


Gly Ile Val Ala Gly 
305                 


<210>  109
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  109

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Leu Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  110
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  110

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn Leu 
65                  70                  75                  80  


Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  111
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  111

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly His 
            100                 105                 110         


Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  112
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  112

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Asn Leu 
65                  70                  75                  80  


Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  113
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  113

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Ser 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Leu Leu Arg Gly His 
            100                 105                 110         


Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  114
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  114

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Tyr Arg Glu Ser Leu Arg Asn Leu 
65                  70                  75                  80  


Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  115
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (182)..(273)
<223>  alpha 3

<400>  115

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Arg Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp 
    


<210>  116
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  116

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  117
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  117

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Asp Arg Ala Tyr Leu Glu Gly Leu Cys Val Glu Ser Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Val Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  118
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  118

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Arg Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  119
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  119

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Phe Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  120
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  120

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Ser Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  121
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (182)..(273)
<223>  alpha 3

<400>  121

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Gln Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp 
    


<210>  122
<211>  362
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(362)
<223>  transmembrane and cytoplasmic tail

<400>  122

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Thr Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  123
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  123

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  124
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  124

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Arg Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  125
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  125

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Val Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  126
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  126

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Gly Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  127
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  127

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Arg Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  128
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  128

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Cys Ala 
            180     


<210>  129
<211>  71
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(71)
<223>  alpha 1

<400>  129

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Xaa 
65                  70      


<210>  130
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  130

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Gly 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  131
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  131

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  132
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  132

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Thr Cys Val Glu Trp Leu Arg Arg His Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  133
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  133

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  134
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(127)
<223>  alpha 2

<400>  134

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Xaa 
        115                 120                 125         


<210>  135
<211>  53
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(53)
<223>  alpha 1

<400>  135

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Xaa 
    50              


<210>  136
<211>  213
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(213)
<223>  alpha 3

<400>  136

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Thr Trp Arg Ala Ser Ala Trp Ser Gly Ser 
            180                 185                 190         


Ala Asp Thr Trp Arg Thr Gly Arg Arg Arg Cys Ser Ala Arg Thr Pro 
        195                 200                 205             


Gln Arg His Thr Xaa 
    210             


<210>  137
<211>  273
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (182)..(273)
<223>  alpha 3

<400>  137

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Met Ala Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His Pro 
            180                 185                 190         


Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr 
        195                 200                 205             


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
    210                 215                 220                 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr Phe 
225                 230                 235                 240 


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr 
                245                 250                 255     


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
            260                 265                 270         


Trp 
    


<210>  138
<211>  298
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(298)
<223>  alpha 3

<400>  138

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp Leu Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp 
    290                 295             


<210>  139
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  139

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Gly Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Leu Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  140
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  140

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Arg 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  141
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  141

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  142
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  142

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Asn Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  143
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  143

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser Gln Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  144
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  144

Ser His Ser Met Arg Tyr Phe His Thr Phe Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  145
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  145

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  146
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  146

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  147
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  147

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Asn Thr Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  148
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  148

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  149
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  149

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Val Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  150
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  150

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser Arg Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  151
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  151

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Trp Gln Thr 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  152
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  152

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Val Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  153
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  153

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Asp 
                165                 170                 175     


Thr Leu Glu Arg Ala 
            180     


<210>  154
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  154

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Gln Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  155
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  155

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Gln Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  156
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  156

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Gly 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  157
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  157

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Trp Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  158
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  158

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Ile Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  159
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  159

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Asn Leu 
65                  70                  75                  80  


Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  160
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  160

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  161
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  161

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  162
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  162

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  163
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  163

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Tyr Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Ser Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  164
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  164

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr Gln 
    50                  55                  60                  


Ile Cys Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  165
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  165

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Ala Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  166
<211>  58
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(58)
<223>  alpha 1

<400>  166

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr 
    50                  55              


<210>  167
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  167

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  168
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  168

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Arg Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  169
<211>  337
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(24)
<223>  signal peptide

<220>
<221>  DOMAIN
<222>  (25)..(114)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (115)..(206)
<223>  alpha 2

<220>
<221>  DOMAIN
<222>  (207)..(309)
<223>  alpha 3

<220>
<221>  DOMAIN
<222>  (310)..(337)
<223>  transmembrane and cytoplasmic tail

<400>  169

Met Arg Val Thr Ala Pro Arg Thr Leu Leu Leu Leu Leu Trp Gly Ala 
1               5                   10                  15      


Val Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


His Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Thr 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Leu Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Ile Cys Lys Ala Lys Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Asp Leu Arg Thr Leu Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Asn Met Tyr Gly Cys Asp Val Arg 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr His Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Ser Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser 
    


<210>  170
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  170

Ser His Cys Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  171
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  171

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Leu 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  172
<211>  181
<212>  PRT
<213>  Homo sapiens


<220>
<221>  DOMAIN
<222>  (1)..(89)
<223>  alpha 1

<220>
<221>  DOMAIN
<222>  (90)..(181)
<223>  alpha 2

<400>  172

Ser His Ser Met Arg Tyr Phe His Thr Ser Val Ser Arg Pro Gly Arg 
1               5                   10                  15      


Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu Phe 
            20                  25                  30          


Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg Ala 
        35                  40                  45              


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr Gln 
    50                  55                  60                  


Ile Cys Lys Ala Lys Ala Gln Thr Asp Arg Glu Asp Leu Arg Thr Leu 
65                  70                  75                  80  


Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Asn 
                85                  90                  95      


Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly Tyr 
            100                 105                 110         


His Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu Asp 
        115                 120                 125             


Leu Ser Ser Trp Ala Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln Arg 
    130                 135                 140                 


Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
145                 150                 155                 160 


Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
                165                 170                 175     


Thr Leu Gln Arg Ala 
            180     


<210>  173
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  173

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  influenza nucleoprotein NP383-391

<400>  174

Ser Arg Tyr Trp Ala Ile Arg Thr Arg 
1               5                   


<210>  175
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBV EBNA3C epitope

<400>  175

Arg Arg Ile Tyr Asp Leu Ile Glu Leu 
1               5                   


<210>  176
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EBV EBNA3C epitope

<400>  176

Thr Pro Arg Thr Gly Gly Gly Ala Met 
1               5                   


