               SEQUENCE LISTING

<110> Aurealis Oy

<120> Recombinant probiotic bacteria

<130> 52647WON1

<150> PCT/EP2015/052345
<151> 2015-02-04

<160> 83

<170> BiSSAP 1.0

<210> 1
<211> 554
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..554
<223> /mol_type="protein"
      /note="macrophage colony-stimulating factor 1 isoform a precursor
      "
      /organism="Homo sapiens"

<400> 1
Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                   15    
Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                   25                  30        
Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                   40                  45            
Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                   55                  60                
Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                   70                  75                  80
Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                   90                  95    
Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                  105                110        
Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                  120                125            
Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                  135                140                
Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                  150                155                  160
Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                  170                175    
Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                  185                190        
Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                  200                205            
Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                  215                220                
Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                  230                235                  240
Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                  250                255    
Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                  265                270        
Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                  280                285            
Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                  295                300                
Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                  310                315                  320
Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                  330                335    
Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                  345                350        
Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                  360                365            
Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                  375                380                
Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                  390                395                  400
Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                  410                415    
Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                  425                430        
Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                  440                445            
Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                  455                460                
Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                  470                475                  480
His Glu Arg Gln Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser 
                485                  490                495    
Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                  505                510        
Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                  520                525            
Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                  535                540                
Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                  550                

<210> 2
<211> 438
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..438
<223> /mol_type="protein"
      /note="macrophage colony-stimulating factor 1 isoform b precursor
      "
      /organism="Homo sapiens"

<400> 2
Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                   15    
Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                   25                  30        
Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                   40                  45            
Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                   55                  60                
Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                   70                  75                  80
Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                   90                  95    
Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                  105                110        
Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                  120                125            
Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                  135                140                
Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                  150                155                  160
Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                  170                175    
Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                  185                190        
Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                  200                205            
Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                  215                220                
Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                  230                235                  240
Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                  250                255    
Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                  265                270        
Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                  280                285            
Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                  295                300                
Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                  310                315                  320
Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                  330                335    
Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                  345                350        
Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly His Glu Arg Gln 
        355                  360                365            
Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser Val Phe His Leu 
    370                  375                380                
Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val Gly Gly Leu Leu 
385                  390                395                  400
Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro Gln Arg Ala Asp 
                405                  410                415    
Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg 
            420                  425                430        
Gln Val Glu Leu Pro Val 
        435            

<210> 3
<211> 256
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..256
<223> /mol_type="protein"
      /note="macrophage colony-stimulating factor 1 isoform c precursor
      "
      /organism="Homo sapiens"

<400> 3
Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                   15    
Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                   25                  30        
Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                   40                  45            
Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                   55                  60                
Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                   70                  75                  80
Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                   90                  95    
Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                  105                110        
Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                  120                125            
Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                  135                140                
Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                  150                155                  160
Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                  170                175    
Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser Ser Ser 
            180                  185                190        
Pro Gln Leu Gln Glu Ser Val Phe His Leu Leu Val Pro Ser Val Ile 
        195                  200                205            
Leu Val Leu Leu Ala Val Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg 
    210                  215                220                
Arg Ser His Gln Glu Pro Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro 
225                  230                235                  240
Glu Gly Ser Pro Leu Thr Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
                245                  250                255    

<210> 4
<211> 149
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..149
<223> /mol_type="protein"
      /note="partial sequence of macrophage colony-stimulating factor 1
      "
      /organism="Homo sapiens"

<400> 4
Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
1               5                   10                   15    
Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
            20                   25                  30        
Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
        35                   40                  45            
Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
    50                   55                  60                
Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
65                   70                  75                  80
Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
                85                   90                  95    
Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
            100                  105                110        
Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
        115                  120                125            
Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
    130                  135                140                
Glu Cys Ser Ser Gln 
145                

<210> 5
<211> 186
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..186
<223> /mol_type="protein"
      /note="synthetic construct hCSF1 precursor protein"
      /organism="artificial sequences"

<400> 5
Met Lys Lys Lys Ile Ile Ser Ala Ile Leu Met Ser Thr Val Ile Leu 
1               5                   10                   15    
Ser Ala Ala Ala Pro Leu Ser Gly Val Tyr Ala Ala Glu Glu Val Ser 
            20                   25                  30        
Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu Gln Ser Leu Gln 
        35                   40                  45            
Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln Ile Thr Phe Glu 
    50                   55                  60                
Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys Tyr Leu Lys Lys 
65                   70                  75                  80
Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr Met Arg Phe Arg 
                85                   90                  95    
Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu Gln Glu Leu Ser 
            100                  105                110        
Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu Glu His Asp Lys 
        115                  120                125            
Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln Leu Leu Glu Lys 
    130                  135                140                
Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu Asp Lys Asp Trp 
145                  150                155                  160
Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala Glu Cys Ser Ser 
                165                  170                175    
Gln Gly His Glu Arg Gln Ser Glu Gly Ser 
            180                  185    

<210> 6
<211> 159
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..159
<223> /mol_type="protein"
      /note="synthetic construct hCSF1"
      /organism="artificial sequences"

<400> 6
Ala Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His 
1               5                   10                   15    
Leu Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys 
            20                   25                  30        
Gln Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val 
        35                   40                  45            
Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp 
    50                   55                  60                
Thr Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln 
65                   70                  75                  80
Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr 
                85                   90                  95    
Glu Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu 
            100                  105                110        
Gln Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu 
        115                  120                125            
Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe 
    130                  135                140                
Ala Glu Cys Ser Ser Gln Gly His Glu Arg Gln Ser Glu Gly Ser 
145                  150                155                

<210> 7
<211> 242
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..242
<223> /mol_type="protein"
      /note="interleukin-34 isoform 1 precursor"
      /organism="Homo sapiens"

<400> 7
Met Pro Arg Gly Phe Thr Trp Leu Arg Tyr Leu Gly Ile Phe Leu Gly 
1               5                   10                   15    
Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn 
            20                   25                  30        
Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg 
        35                   40                  45            
Ser Arg Leu Gln Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile 
    50                   55                  60                
Ser Val Pro Tyr Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu 
65                   70                  75                  80
Gln Arg Ala Gln Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu 
                85                   90                  95    
Val Ser Leu Ser Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly 
            100                  105                110        
His Pro Ser Trp Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn 
        115                  120                125            
Val Gln Gln Gly Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser 
    130                  135                140                
Val Leu Ser Leu Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg 
145                  150                155                  160
Pro Lys Ala Leu Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr 
                165                  170                175    
Cys Ser Cys Cys Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu 
            180                  185                190        
Val Pro Ser Pro Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala 
        195                  200                205            
Ala Thr Gln Leu Tyr Pro Pro Pro Pro Trp Ser Pro Ser Ser Pro Pro 
    210                  215                220                
His Ser Thr Gly Ser Val Arg Pro Val Arg Ala Gln Gly Glu Gly Leu 
225                  230                235                  240
Leu Pro 
        

<210> 8
<211> 241
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..241
<223> /mol_type="protein"
      /note="interleukin-34 isoform 2 precursor"
      /organism="Homo sapiens"

<400> 8
Met Pro Arg Gly Phe Thr Trp Leu Arg Tyr Leu Gly Ile Phe Leu Gly 
1               5                   10                   15    
Val Ala Leu Gly Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn 
            20                   25                  30        
Glu Glu Cys Thr Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg 
        35                   40                  45            
Ser Arg Leu Gln Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile 
    50                   55                  60                
Ser Val Pro Tyr Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu 
65                   70                  75                  80
Arg Ala Gln Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu Val 
                85                   90                  95    
Ser Leu Ser Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly His 
            100                  105                110        
Pro Ser Trp Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn Val 
        115                  120                125            
Gln Gln Gly Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser Val 
    130                  135                140                
Leu Ser Leu Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg Pro 
145                  150                155                  160
Lys Ala Leu Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys 
                165                  170                175    
Ser Cys Cys Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Val 
            180                  185                190        
Pro Ser Pro Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala Ala 
        195                  200                205            
Thr Gln Leu Tyr Pro Pro Pro Pro Trp Ser Pro Ser Ser Pro Pro His 
    210                  215                220                
Ser Thr Gly Ser Val Arg Pro Val Arg Ala Gln Gly Glu Gly Leu Leu 
225                  230                235                  240
Pro 
    

<210> 9
<211> 222
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..222
<223> /mol_type="protein"
      /note="interleukin-34"
      /organism="Homo sapiens"

<400> 9
Asn Glu Pro Leu Glu Met Trp Pro Leu Thr Gln Asn Glu Glu Cys Thr 
1               5                   10                   15    
Val Thr Gly Phe Leu Arg Asp Lys Leu Gln Tyr Arg Ser Arg Leu Gln 
            20                   25                  30        
Tyr Met Lys His Tyr Phe Pro Ile Asn Tyr Lys Ile Ser Val Pro Tyr 
        35                   40                  45            
Glu Gly Val Phe Arg Ile Ala Asn Val Thr Arg Leu Gln Arg Ala Gln 
    50                   55                  60                
Val Ser Glu Arg Glu Leu Arg Tyr Leu Trp Val Leu Val Ser Leu Ser 
65                   70                  75                  80
Ala Thr Glu Ser Val Gln Asp Val Leu Leu Glu Gly His Pro Ser Trp 
                85                   90                  95    
Lys Tyr Leu Gln Glu Val Glu Thr Leu Leu Leu Asn Val Gln Gln Gly 
            100                  105                110        
Leu Thr Asp Val Glu Val Ser Pro Lys Val Glu Ser Val Leu Ser Leu 
        115                  120                125            
Leu Asn Ala Pro Gly Pro Asn Leu Lys Leu Val Arg Pro Lys Ala Leu 
    130                  135                140                
Leu Asp Asn Cys Phe Arg Val Met Glu Leu Leu Tyr Cys Ser Cys Cys 
145                  150                155                  160
Lys Gln Ser Ser Val Leu Asn Trp Gln Asp Cys Glu Val Pro Ser Pro 
                165                  170                175    
Gln Ser Cys Ser Pro Glu Pro Ser Leu Gln Tyr Ala Ala Thr Gln Leu 
            180                  185                190        
Tyr Pro Pro Pro Pro Trp Ser Pro Ser Ser Pro Pro His Ser Thr Gly 
        195                  200                205            
Ser Val Arg Pro Val Arg Ala Gln Gly Glu Gly Leu Leu Pro 
    210                  215                220        

<210> 10
<211> 153
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..153
<223> /mol_type="protein"
      /note="interleukin-4 isoform 1 precursor"
      /organism="Homo sapiens"

<400> 10
Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                   15    
Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                   25                  30        
Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                   40                  45            
Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                   55                  60                
Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                   70                  75                  80
Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                   90                  95    
Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                  105                110        
Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                  120                125            
Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                  135                140                
Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                  150            

<210> 11
<211> 137
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..137
<223> /mol_type="protein"
      /note="interleukin-4 isoform 2 precursor"
      /organism="Homo sapiens"

<400> 11
Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                   15    
Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                   25                  30        
Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Asn Thr Thr 
        35                   40                  45            
Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
    50                   55                  60                
Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
65                   70                  75                  80
Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
                85                   90                  95    
Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
            100                  105                110        
Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
        115                  120                125            
Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
    130                  135        

<210> 12
<211> 129
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..129
<223> /mol_type="protein"
      /note="interleukin-4"
      /organism="Homo sapiens"

<400> 12
His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser 
1               5                   10                   15    
Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile 
            20                   25                  30        
Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala 
        35                   40                  45            
Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg 
    50                   55                  60                
Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile 
65                   70                  75                  80
Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu 
                85                   90                  95    
Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe 
            100                  105                110        
Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser 
        115                  120                125            
Ser 
    

<210> 13
<211> 157
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..157
<223> /mol_type="protein"
      /note="synthetic construct hIL4 precursor protein"
      /organism="artificial sequences"

<400> 13
Met Lys Lys Lys Ile Ile Ser Ala Ile Leu Met Ser Thr Val Ile Leu 
1               5                   10                   15    
Ser Ala Ala Ala Pro Leu Ser Gly Val Tyr Ala Ala His Lys Cys Asp 
            20                   25                  30        
Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln 
        35                   40                  45            
Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser 
    50                   55                  60                
Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu 
65                   70                  75                  80
Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala 
                85                   90                  95    
Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys 
            100                  105                110        
Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro 
        115                  120                125            
Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu 
    130                  135                140                
Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                  150                155        

<210> 14
<211> 130
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..130
<223> /mol_type="protein"
      /note="synthetic construct hIL4"
      /organism="artificial sequences"

<400> 14
Ala His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn 
1               5                   10                   15    
Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp 
            20                   25                  30        
Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg 
        35                   40                  45            
Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr 
    50                   55                  60                
Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu 
65                   70                  75                  80
Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly 
                85                   90                  95    
Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn 
            100                  105                110        
Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys 
        115                  120                125            
Ser Ser 
    130

<210> 15
<211> 178
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..178
<223> /mol_type="protein"
      /note="interleukin-10 precursor"
      /organism="Homo sapiens"

<400> 15
Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                   15    
Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                   25                  30        
Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                   40                  45            
Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                   55                  60                
Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                   70                  75                  80
Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                   90                  95    
Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                  105                110        
Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                  120                125            
Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                  135                140                
Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                  150                155                  160
Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                  170                175    
Arg Asn 
        

<210> 16
<211> 160
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..160
<223> /mol_type="protein"
      /note="interleukin-10"
      /organism="Homo sapiens"

<400> 16
Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro 
1               5                   10                   15    
Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg 
            20                   25                  30        
Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu 
        35                   40                  45            
Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala 
    50                   55                  60                
Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala 
65                   70                  75                  80
Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu 
                85                   90                  95    
Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu 
            100                  105                110        
Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe 
        115                  120                125            
Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp 
    130                  135                140                
Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 
145                  150                155                  160

<210> 17
<211> 146
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..146
<223> /mol_type="protein"
      /note="interleukin-13 precursor"
      /organism="Homo sapiens"

<400> 17
Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                   15    
Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                   25                  30        
Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                   40                  45            
Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                   55                  60                
Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                   70                  75                  80
Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                   90                  95    
Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                  105                110        
Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                  120                125            
Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Arg 
    130                  135                140                
Phe Asn 
145    

<210> 18
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..112
<223> /mol_type="protein"
      /note="interleukin-13"
      /organism="Homo sapiens"

<400> 18
Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu 
1               5                   10                   15    
Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met 
            20                   25                  30        
Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu 
        35                   40                  45            
Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg 
    50                   55                  60                
Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe Ser 
65                   70                  75                  80
Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe Val Lys 
                85                   90                  95    
Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Arg Phe Asn 
            100                  105                110        

<210> 19
<211> 390
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..390
<223> /mol_type="protein"
      /note="transforming growth factor beta-1 precursor"
      /organism="Homo sapiens"

<400> 19
Met Pro Pro Ser Gly Leu Arg Leu Leu Pro Leu Leu Leu Pro Leu Leu 
1               5                   10                   15    
Trp Leu Leu Val Leu Thr Pro Gly Arg Pro Ala Ala Gly Leu Ser Thr 
            20                   25                  30        
Cys Lys Thr Ile Asp Met Glu Leu Val Lys Arg Lys Arg Ile Glu Ala 
        35                   40                  45            
Ile Arg Gly Gln Ile Leu Ser Lys Leu Arg Leu Ala Ser Pro Pro Ser 
    50                   55                  60                
Gln Gly Glu Val Pro Pro Gly Pro Leu Pro Glu Ala Val Leu Ala Leu 
65                   70                  75                  80
Tyr Asn Ser Thr Arg Asp Arg Val Ala Gly Glu Ser Ala Glu Pro Glu 
                85                   90                  95    
Pro Glu Pro Glu Ala Asp Tyr Tyr Ala Lys Glu Val Thr Arg Val Leu 
            100                  105                110        
Met Val Glu Thr His Asn Glu Ile Tyr Asp Lys Phe Lys Gln Ser Thr 
        115                  120                125            
His Ser Ile Tyr Met Phe Phe Asn Thr Ser Glu Leu Arg Glu Ala Val 
    130                  135                140                
Pro Glu Pro Val Leu Leu Ser Arg Ala Glu Leu Arg Leu Leu Arg Leu 
145                  150                155                  160
Lys Leu Lys Val Glu Gln His Val Glu Leu Tyr Gln Lys Tyr Ser Asn 
                165                  170                175    
Asn Ser Trp Arg Tyr Leu Ser Asn Arg Leu Leu Ala Pro Ser Asp Ser 
            180                  185                190        
Pro Glu Trp Leu Ser Phe Asp Val Thr Gly Val Val Arg Gln Trp Leu 
        195                  200                205            
Ser Arg Gly Gly Glu Ile Glu Gly Phe Arg Leu Ser Ala His Cys Ser 
    210                  215                220                
Cys Asp Ser Arg Asp Asn Thr Leu Gln Val Asp Ile Asn Gly Phe Thr 
225                  230                235                  240
Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met Asn Arg Pro 
                245                  250                255    
Phe Leu Leu Leu Met Ala Thr Pro Leu Glu Arg Ala Gln His Leu Gln 
            260                  265                270        
Ser Ser Arg His Arg Arg Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser 
        275                  280                285            
Thr Glu Lys Asn Cys Cys Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys 
    290                  295                300                
Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly Tyr His Ala Asn 
305                  310                315                  320
Phe Cys Leu Gly Pro Cys Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr 
                325                  330                335    
Ser Lys Val Leu Ala Leu Tyr Asn Gln His Asn Pro Gly Ala Ser Ala 
            340                  345                350        
Ala Pro Cys Cys Val Pro Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr 
        355                  360                365            
Tyr Val Gly Arg Lys Pro Lys Val Glu Gln Leu Ser Asn Met Ile Val 
    370                  375                380                
Arg Ser Cys Lys Cys Ser 
385                  390

<210> 20
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..112
<223> /mol_type="protein"
      /note="transforming growth factor beta-1"
      /organism="Homo sapiens"

<400> 20
Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                   15    
Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                   25                  30        
Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                   40                  45            
Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                   55                  60                
Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                   70                  75                  80
Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                   90                  95    
Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                  105                110        

<210> 21
<211> 442
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..442
<223> /mol_type="protein"
      /note="transforming growth factor beta-2 isoform 1 precursor"
      /organism="Homo sapiens"

<400> 21
Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                   15    
Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                   25                  30        
Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                   40                  45            
Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                   55                  60                
Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                   70                  75                  80
Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                   90                  95    
Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                  105                110        
Pro Ser Glu Thr Val Cys Pro Val Val Thr Thr Pro Ser Gly Ser Val 
        115                  120                125            
Gly Ser Leu Cys Ser Arg Gln Ser Gln Val Leu Cys Gly Tyr Leu Asp 
    130                  135                140                
Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg Ile Val Arg Phe 
145                  150                155                  160
Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu Val Lys Ala Glu 
                165                  170                175    
Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg Val Pro Glu Gln 
            180                  185                190        
Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp Leu Thr Ser Pro 
        195                  200                205            
Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr Arg Ala Glu Gly 
    210                  215                220                
Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His Glu Trp Leu His 
225                  230                235                  240
His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu His Cys Pro Cys 
                245                  250                255    
Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro Asn Lys Ser Glu 
            260                  265                270        
Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr Ser Thr Tyr Thr 
        275                  280                285            
Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys Lys Asn Ser Gly 
    290                  295                300                
Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser Tyr Arg Leu Glu 
305                  310                315                  320
Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu Asp Ala Ala Tyr 
                325                  330                335    
Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg Pro Leu Tyr Ile 
            340                  345                350        
Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His Glu Pro Lys Gly 
        355                  360                365            
Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr Leu Trp Ser Ser 
    370                  375                380                
Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn Thr Ile Asn Pro 
385                  390                395                  400
Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp Leu Glu Pro Leu 
                405                  410                415    
Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile Glu Gln Leu Ser 
            420                  425                430        
Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
        435                  440        

<210> 22
<211> 414
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..414
<223> /mol_type="protein"
      /note="transforming growth factor beta-2 isoform 2 precursor"
      /organism="Homo sapiens"

<400> 22
Met His Tyr Cys Val Leu Ser Ala Phe Leu Ile Leu His Leu Val Thr 
1               5                   10                   15    
Val Ala Leu Ser Leu Ser Thr Cys Ser Thr Leu Asp Met Asp Gln Phe 
            20                   25                  30        
Met Arg Lys Arg Ile Glu Ala Ile Arg Gly Gln Ile Leu Ser Lys Leu 
        35                   40                  45            
Lys Leu Thr Ser Pro Pro Glu Asp Tyr Pro Glu Pro Glu Glu Val Pro 
    50                   55                  60                
Pro Glu Val Ile Ser Ile Tyr Asn Ser Thr Arg Asp Leu Leu Gln Glu 
65                   70                  75                  80
Lys Ala Ser Arg Arg Ala Ala Ala Cys Glu Arg Glu Arg Ser Asp Glu 
                85                   90                  95    
Glu Tyr Tyr Ala Lys Glu Val Tyr Lys Ile Asp Met Pro Pro Phe Phe 
            100                  105                110        
Pro Ser Glu Asn Ala Ile Pro Pro Thr Phe Tyr Arg Pro Tyr Phe Arg 
        115                  120                125            
Ile Val Arg Phe Asp Val Ser Ala Met Glu Lys Asn Ala Ser Asn Leu 
    130                  135                140                
Val Lys Ala Glu Phe Arg Val Phe Arg Leu Gln Asn Pro Lys Ala Arg 
145                  150                155                  160
Val Pro Glu Gln Arg Ile Glu Leu Tyr Gln Ile Leu Lys Ser Lys Asp 
                165                  170                175    
Leu Thr Ser Pro Thr Gln Arg Tyr Ile Asp Ser Lys Val Val Lys Thr 
            180                  185                190        
Arg Ala Glu Gly Glu Trp Leu Ser Phe Asp Val Thr Asp Ala Val His 
        195                  200                205            
Glu Trp Leu His His Lys Asp Arg Asn Leu Gly Phe Lys Ile Ser Leu 
    210                  215                220                
His Cys Pro Cys Cys Thr Phe Val Pro Ser Asn Asn Tyr Ile Ile Pro 
225                  230                235                  240
Asn Lys Ser Glu Glu Leu Glu Ala Arg Phe Ala Gly Ile Asp Gly Thr 
                245                  250                255    
Ser Thr Tyr Thr Ser Gly Asp Gln Lys Thr Ile Lys Ser Thr Arg Lys 
            260                  265                270        
Lys Asn Ser Gly Lys Thr Pro His Leu Leu Leu Met Leu Leu Pro Ser 
        275                  280                285            
Tyr Arg Leu Glu Ser Gln Gln Thr Asn Arg Arg Lys Lys Arg Ala Leu 
    290                  295                300                
Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys Leu Arg 
305                  310                315                  320
Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp Ile His 
                325                  330                335    
Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys Pro Tyr 
            340                  345                350        
Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu Tyr Asn 
        355                  360                365            
Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser Gln Asp 
    370                  375                380                
Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro Lys Ile 
385                  390                395                  400
Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
                405                  410                

<210> 23
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..112
<223> /mol_type="protein"
      /note="transforming growth factor beta-2"
      /organism="Homo sapiens"

<400> 23
Ala Leu Asp Ala Ala Tyr Cys Phe Arg Asn Val Gln Asp Asn Cys Cys 
1               5                   10                   15    
Leu Arg Pro Leu Tyr Ile Asp Phe Lys Arg Asp Leu Gly Trp Lys Trp 
            20                   25                  30        
Ile His Glu Pro Lys Gly Tyr Asn Ala Asn Phe Cys Ala Gly Ala Cys 
        35                   40                  45            
Pro Tyr Leu Trp Ser Ser Asp Thr Gln His Ser Arg Val Leu Ser Leu 
    50                   55                  60                
Tyr Asn Thr Ile Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Ser 
65                   70                  75                  80
Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Ile Gly Lys Thr Pro 
                85                   90                  95    
Lys Ile Glu Gln Leu Ser Asn Met Ile Val Lys Ser Cys Lys Cys Ser 
            100                  105                110        

<210> 24
<211> 412
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..412
<223> /mol_type="protein"
      /note="transforming growth factor beta-3 preproprotein"
      /organism="Homo sapiens"

<400> 24
Met Lys Met His Leu Gln Arg Ala Leu Val Val Leu Ala Leu Leu Asn 
1               5                   10                   15    
Phe Ala Thr Val Ser Leu Ser Leu Ser Thr Cys Thr Thr Leu Asp Phe 
            20                   25                  30        
Gly His Ile Lys Lys Lys Arg Val Glu Ala Ile Arg Gly Gln Ile Leu 
        35                   40                  45            
Ser Lys Leu Arg Leu Thr Ser Pro Pro Glu Pro Thr Val Met Thr His 
    50                   55                  60                
Val Pro Tyr Gln Val Leu Ala Leu Tyr Asn Ser Thr Arg Glu Leu Leu 
65                   70                  75                  80
Glu Glu Met His Gly Glu Arg Glu Glu Gly Cys Thr Gln Glu Asn Thr 
                85                   90                  95    
Glu Ser Glu Tyr Tyr Ala Lys Glu Ile His Lys Phe Asp Met Ile Gln 
            100                  105                110        
Gly Leu Ala Glu His Asn Glu Leu Ala Val Cys Pro Lys Gly Ile Thr 
        115                  120                125            
Ser Lys Val Phe Arg Phe Asn Val Ser Ser Val Glu Lys Asn Arg Thr 
    130                  135                140                
Asn Leu Phe Arg Ala Glu Phe Arg Val Leu Arg Val Pro Asn Pro Ser 
145                  150                155                  160
Ser Lys Arg Asn Glu Gln Arg Ile Glu Leu Phe Gln Ile Leu Arg Pro 
                165                  170                175    
Asp Glu His Ile Ala Lys Gln Arg Tyr Ile Gly Gly Lys Asn Leu Pro 
            180                  185                190        
Thr Arg Gly Thr Ala Glu Trp Leu Ser Phe Asp Val Thr Asp Thr Val 
        195                  200                205            
Arg Glu Trp Leu Leu Arg Arg Glu Ser Asn Leu Gly Leu Glu Ile Ser 
    210                  215                220                
Ile His Cys Pro Cys His Thr Phe Gln Pro Asn Gly Asp Ile Leu Glu 
225                  230                235                  240
Asn Ile His Glu Val Met Glu Ile Lys Phe Lys Gly Val Asp Asn Glu 
                245                  250                255    
Asp Asp His Gly Arg Gly Asp Leu Gly Arg Leu Lys Lys Gln Lys Asp 
            260                  265                270        
His His Asn Pro His Leu Ile Leu Met Met Ile Pro Pro His Arg Leu 
        275                  280                285            
Asp Asn Pro Gly Gln Gly Gly Gln Arg Lys Lys Arg Ala Leu Asp Thr 
    290                  295                300                
Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys Val Arg Pro Leu 
305                  310                315                  320
Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp Val His Glu Pro 
                325                  330                335    
Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys Pro Tyr Leu Arg 
            340                  345                350        
Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu Tyr Asn Thr Leu 
        355                  360                365            
Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro Gln Asp Leu Glu 
    370                  375                380                
Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro Lys Val Glu Gln 
385                  390                395                  400
Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
                405                  410        

<210> 25
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..112
<223> /mol_type="protein"
      /note="transforming growth factor beta-3"
      /organism="Homo sapiens"

<400> 25
Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                   15    
Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                   25                  30        
Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                   40                  45            
Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                   55                  60                
Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                   70                  75                  80
Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                   90                  95    
Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                  105                110        

<210> 26
<211> 288
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..288
<223> /mol_type="protein"
      /note="fibroblast growth factor 2 precursor"
      /organism="Homo sapiens"

<400> 26
Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                   15    
Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                   25                  30        
Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                   40                  45            
Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                   55                  60                
Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                   70                  75                  80
Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                   90                  95    
Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                  105                110        
Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                  120                125            
Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                  135                140                
Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                  150                155                  160
Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                  170                175    
His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                  185                190        
Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                  200                205            
Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                  215                220                
Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                  230                235                  240
Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                  250                255    
Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                  265                270        
Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                  280                285            

<210> 27
<211> 155
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..155
<223> /mol_type="protein"
      /note="mature  FGF2"
      /organism="Homo sapiens"

<400> 27
Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                   15    
Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                   25                  30        
Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                   40                  45            
Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                   55                  60                
Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                   70                  75                  80
Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                   90                  95    
Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                  105                110        
Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                  120                125            
Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                  135                140                
Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                  150                155

<210> 28
<211> 146
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..146
<223> /mol_type="protein"
      /note="fragment of fibroblast growth factor 2"
      /organism="Homo sapiens"

<400> 28
Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His 
1               5                   10                   15    
Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu 
            20                   25                  30        
Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp 
        35                   40                  45            
Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser 
    50                   55                  60                
Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly 
65                   70                  75                  80
Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu 
                85                   90                  95    
Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr 
            100                  105                110        
Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser 
        115                  120                125            
Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala 
    130                  135                140                
Lys Ser 
145    

<210> 29
<211> 180
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..180
<223> /mol_type="protein"
      /note="sythetic construct  hFGF2-153 precursor protein "
      /organism="artificial sequences"

<400> 29
Met Lys Lys Lys Ile Ile Ser Ala Ile Leu Met Ser Thr Val Ile Leu 
1               5                   10                   15    
Ser Ala Ala Ala Pro Leu Ser Gly Val Tyr Ala Ala Gly Ser Ile Thr 
            20                   25                  30        
Thr Leu Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro 
        35                   40                  45            
Gly His Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe 
    50                   55                  60                
Phe Leu Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys 
65                   70                  75                  80
Ser Asp Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val 
                85                   90                  95    
Val Ser Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu 
            100                  105                110        
Asp Gly Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe 
        115                  120                125            
Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys 
    130                  135                140                
Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu 
145                  150                155                  160
Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met 
                165                  170                175    
Ser Ala Lys Ser 
            180

<210> 30
<211> 153
<212> PRT
<213> artificial sequences

<220> 
<221> SOURCE
<222> 1..153
<223> /mol_type="protein"
      /note="synthetic construct hFGF2-153"
      /organism="artificial sequences"

<400> 30
Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly Gly Ser 
1               5                   10                   15    
Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr Cys 
            20                   25                  30        
Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val Asp 
        35                   40                  45            
Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu Gln Ala 
    50                   55                  60                
Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg Tyr 
65                   70                  75                  80
Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val Thr 
                85                   90                  95    
Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn Thr 
            100                  105                110        
Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys Arg Thr 
        115                  120                125            
Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala Ile 
    130                  135                140                
Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                  150            

<210> 31
<211> 728
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..728
<223> /mol_type="protein"
      /note="hepatocyte growth factor"
      /organism="Homo sapiens"

<400> 31
Met Trp Val Thr Lys Leu Leu Pro Ala Leu Leu Leu Gln His Val Leu 
1               5                   10                   15    
Leu His Leu Leu Leu Leu Pro Ile Ala Ile Pro Tyr Ala Glu Gly Gln 
            20                   25                  30        
Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys Thr 
        35                   40                  45            
Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys Val 
    50                   55                  60                
Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly Leu 
65                   70                  75                  80
Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln Cys 
                85                   90                  95    
Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu Phe 
            100                  105                110        
Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn Cys 
        115                  120                125            
Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr Lys 
    130                  135                140                
Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu His 
145                  150                155                  160
Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn Tyr 
                165                  170                175    
Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr Ser 
            180                  185                190        
Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser Glu 
        195                  200                205            
Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met Asp 
    210                  215                220                
His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr Pro 
225                  230                235                  240
His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe Asp 
                245                  250                255    
Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys Tyr 
            260                  265                270        
Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr Cys 
        275                  280                285            
Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr Glu 
    290                  295                300                
Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr Ile 
305                  310                315                  320
Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His Glu 
                325                  330                335    
His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu Asn 
            340                  345                350        
Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr Thr 
        355                  360                365            
Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys Asp 
    370                  375                380                
Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr Met 
385                  390                395                  400
Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp Asp 
                405                  410                415    
Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp Ala 
            420                  425                430        
Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala His 
        435                  440                445            
Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr Cys 
    450                  455                460                
Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn Leu 
465                  470                475                  480
Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg Val Val 
                485                  490                495    
Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser Leu Arg 
            500                  505                510        
Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu Ser Trp 
        515                  520                525            
Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys Asp Tyr 
    530                  535                540                
Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp Glu Lys 
545                  550                555                  560
Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro Glu Gly 
                565                  570                575    
Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu Asp Asp 
            580                  585                590        
Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile Pro Glu 
        595                  600                605            
Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu Ile Asn 
    610                  615                620                
Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly Asn Glu 
625                  630                635                  640
Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu Ser Glu 
                645                  650                655    
Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu Gly Asp 
            660                  665                670        
Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met Val Leu 
        675                  680                685            
Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg Pro Gly 
    690                  695                700                
Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys Ile Ile 
705                  710                715                  720
Leu Thr Tyr Lys Val Pro Gln Ser 
                725            

<210> 32
<211> 463
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..463
<223> /mol_type="protein"
      /note="hepatocyte growth factor alpha chain"
      /organism="Homo sapiens"

<400> 32
Gln Arg Lys Arg Arg Asn Thr Ile His Glu Phe Lys Lys Ser Ala Lys 
1               5                   10                   15    
Thr Thr Leu Ile Lys Ile Asp Pro Ala Leu Lys Ile Lys Thr Lys Lys 
            20                   25                  30        
Val Asn Thr Ala Asp Gln Cys Ala Asn Arg Cys Thr Arg Asn Lys Gly 
        35                   40                  45            
Leu Pro Phe Thr Cys Lys Ala Phe Val Phe Asp Lys Ala Arg Lys Gln 
    50                   55                  60                
Cys Leu Trp Phe Pro Phe Asn Ser Met Ser Ser Gly Val Lys Lys Glu 
65                   70                  75                  80
Phe Gly His Glu Phe Asp Leu Tyr Glu Asn Lys Asp Tyr Ile Arg Asn 
                85                   90                  95    
Cys Ile Ile Gly Lys Gly Arg Ser Tyr Lys Gly Thr Val Ser Ile Thr 
            100                  105                110        
Lys Ser Gly Ile Lys Cys Gln Pro Trp Ser Ser Met Ile Pro His Glu 
        115                  120                125            
His Ser Phe Leu Pro Ser Ser Tyr Arg Gly Lys Asp Leu Gln Glu Asn 
    130                  135                140                
Tyr Cys Arg Asn Pro Arg Gly Glu Glu Gly Gly Pro Trp Cys Phe Thr 
145                  150                155                  160
Ser Asn Pro Glu Val Arg Tyr Glu Val Cys Asp Ile Pro Gln Cys Ser 
                165                  170                175    
Glu Val Glu Cys Met Thr Cys Asn Gly Glu Ser Tyr Arg Gly Leu Met 
            180                  185                190        
Asp His Thr Glu Ser Gly Lys Ile Cys Gln Arg Trp Asp His Gln Thr 
        195                  200                205            
Pro His Arg His Lys Phe Leu Pro Glu Arg Tyr Pro Asp Lys Gly Phe 
    210                  215                220                
Asp Asp Asn Tyr Cys Arg Asn Pro Asp Gly Gln Pro Arg Pro Trp Cys 
225                  230                235                  240
Tyr Thr Leu Asp Pro His Thr Arg Trp Glu Tyr Cys Ala Ile Lys Thr 
                245                  250                255    
Cys Ala Asp Asn Thr Met Asn Asp Thr Asp Val Pro Leu Glu Thr Thr 
            260                  265                270        
Glu Cys Ile Gln Gly Gln Gly Glu Gly Tyr Arg Gly Thr Val Asn Thr 
        275                  280                285            
Ile Trp Asn Gly Ile Pro Cys Gln Arg Trp Asp Ser Gln Tyr Pro His 
    290                  295                300                
Glu His Asp Met Thr Pro Glu Asn Phe Lys Cys Lys Asp Leu Arg Glu 
305                  310                315                  320
Asn Tyr Cys Arg Asn Pro Asp Gly Ser Glu Ser Pro Trp Cys Phe Thr 
                325                  330                335    
Thr Asp Pro Asn Ile Arg Val Gly Tyr Cys Ser Gln Ile Pro Asn Cys 
            340                  345                350        
Asp Met Ser His Gly Gln Asp Cys Tyr Arg Gly Asn Gly Lys Asn Tyr 
        355                  360                365            
Met Gly Asn Leu Ser Gln Thr Arg Ser Gly Leu Thr Cys Ser Met Trp 
    370                  375                380                
Asp Lys Asn Met Glu Asp Leu His Arg His Ile Phe Trp Glu Pro Asp 
385                  390                395                  400
Ala Ser Lys Leu Asn Glu Asn Tyr Cys Arg Asn Pro Asp Asp Asp Ala 
                405                  410                415    
His Gly Pro Trp Cys Tyr Thr Gly Asn Pro Leu Ile Pro Trp Asp Tyr 
            420                  425                430        
Cys Pro Ile Ser Arg Cys Glu Gly Asp Thr Thr Pro Thr Ile Val Asn 
        435                  440                445            
Leu Asp His Pro Val Ile Ser Cys Ala Lys Thr Lys Gln Leu Arg 
    450                  455                460            

<210> 33
<211> 234
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..234
<223> /mol_type="protein"
      /note="hepatocyte growth factor beta chain"
      /organism="Homo sapiens"

<400> 33
Val Val Asn Gly Ile Pro Thr Arg Thr Asn Ile Gly Trp Met Val Ser 
1               5                   10                   15    
Leu Arg Tyr Arg Asn Lys His Ile Cys Gly Gly Ser Leu Ile Lys Glu 
            20                   25                  30        
Ser Trp Val Leu Thr Ala Arg Gln Cys Phe Pro Ser Arg Asp Leu Lys 
        35                   40                  45            
Asp Tyr Glu Ala Trp Leu Gly Ile His Asp Val His Gly Arg Gly Asp 
    50                   55                  60                
Glu Lys Cys Lys Gln Val Leu Asn Val Ser Gln Leu Val Tyr Gly Pro 
65                   70                  75                  80
Glu Gly Ser Asp Leu Val Leu Met Lys Leu Ala Arg Pro Ala Val Leu 
                85                   90                  95    
Asp Asp Phe Val Ser Thr Ile Asp Leu Pro Asn Tyr Gly Cys Thr Ile 
            100                  105                110        
Pro Glu Lys Thr Ser Cys Ser Val Tyr Gly Trp Gly Tyr Thr Gly Leu 
        115                  120                125            
Ile Asn Tyr Asp Gly Leu Leu Arg Val Ala His Leu Tyr Ile Met Gly 
    130                  135                140                
Asn Glu Lys Cys Ser Gln His His Arg Gly Lys Val Thr Leu Asn Glu 
145                  150                155                  160
Ser Glu Ile Cys Ala Gly Ala Glu Lys Ile Gly Ser Gly Pro Cys Glu 
                165                  170                175    
Gly Asp Tyr Gly Gly Pro Leu Val Cys Glu Gln His Lys Met Arg Met 
            180                  185                190        
Val Leu Gly Val Ile Val Pro Gly Arg Gly Cys Ala Ile Pro Asn Arg 
        195                  200                205            
Pro Gly Ile Phe Val Arg Val Ala Tyr Tyr Ala Lys Trp Ile His Lys 
    210                  215                220                
Ile Ile Leu Thr Tyr Lys Val Pro Gln Ser 
225                  230                

<210> 34
<211> 27
<212> PRT
<213> Lactococcus lactis

<220> 
<221> SOURCE
<222> 1..27
<223> /mol_type="protein"
      /note="Usp45 secretion signal"
      /organism="Lactococcus lactis"

<400> 34
Met Lys Lys Lys Ile Ile Ser Ala Ile Leu Met Ser Thr Val Ile Leu 
1               5                   10                   15    
Ser Ala Ala Ala Pro Leu Ser Gly Val Tyr Ala 
            20                   25        

<210> 35
<211> 2550
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..2550
<223> /mol_type="DNA"
      /note="plasmid pNZ8149 "
      /organism="artificial sequences"

<400> 35
ggatctagtc ttataactat actgacaata gaaacattaa caaatctaaa acagtcttaa      60

ttctatcttg agaaagtatt ggtaataata ttattgtcga taacgcgagc ataataaacg     120

gctctgatta aattctgaag tttgttagat acaatgattt cgttcgaagg aactacaaaa     180

taaattataa ggaggcactc accatgggta ctgcaggcat gcggtaccac tagttctaga     240

gagctcaagc tttctttgaa ccaaaattag aaaaccaagg cttgaaacgt tcaattgaaa     300

tggcaattaa acaaattaca gcacgtgttg ctttgattga tagccaaaaa gcagcagttg     360

ataaagcaat tactgatatt gctgaaaaat tgtaatttat aaataaaaat caccttttag     420

aggtggtttt tttatttata aattattcgt ttgatttcgc tttcgataga acaatcaaat     480

cgtttctgag acgttttagc gtttatttcg tttagttatc ggcataatcg ttaaaacagg     540

cgttatcgta gcgtaaaagc ccttgagcgt agcgtggctt tgcagcgaag atgttgtctg     600

ttagattatg aaagccgatg actgaatgaa ataataagcg cagcgtcctt ctatttcggt     660

tggaggaggc tcaagggagt ttgagggaat gaaattccct catgggtttg attttaaaaa     720

ttgcttgcaa ttttgccgag cggtagcgct ggaaaatttt tgaaaaaaat ttggaatttg     780

gaaaaaaatg gggggaaagg aagcgaattt tgcttccgta ctacgacccc ccattaagtg     840

ccgagtgcca atttttgtgc caaaaacgct ctatcccaac tggctcaagg gtttgagggg     900

tttttcaatc gccaacgaat cgccaacgtt ttcgccaacg ttttttataa atctatattt     960

aagtagcttt atttttgttt ttatgattac aaagtgatac actaatttta taaaattatt    1020

tgattggagt tttttaaatg gtgatttcag aatcgaaaaa aagagttatg atttctctga    1080

caaaagagca agataaaaaa ttaacagata tggcgaaaca aaaagatttt tcaaaatctg    1140

cggttgcggc gttagctata gaagaatatg caagaaagga atcagaacaa aaaaaataag    1200

cgaaagctcg cgtttttaga aggatacgag ttttcgctac ttgtttttga taaggtaatt    1260

atatcatggc tattaaaaat actaaagcta gaaattttgg atttttatta tatcctgact    1320

caattcctaa tgattggaaa gaaaaattag agagtttggg cgtatctatg gctgtcagtc    1380

ctttacacga tatggacgaa aaaaaagata aagatacatg gaatagtagt gatgttatac    1440

gaaatggaaa gcactataaa aaaccacact atcacgttat atatattgca cgaaatcctg    1500

taacaataga aagcgttagg aacaagatta agcgaaaatt ggggaatagt tcagttgctc    1560

atgttgagat acttgattat atcaaaggtt catatgaata tttgactcat gaatcaaagg    1620

acgctattgc taagaataaa catatatacg acaaaaaaga tattttgaac attaatgatt    1680

ttgatattga ccgctatata acacttgatg aaagccaaaa aagagaattg aagaatttac    1740

ttttagatat agtggatgac tataatttgg taaatacaaa agatttaatg gcttttattc    1800

gccttagggg agcggagttt ggaattttaa atacgaatga tgtaaaagat attgtttcaa    1860

caaactctag cgcctttaga ttatggtttg agggcaatta tcagtgtgga tatagagcaa    1920

gttatgcaaa ggttcttgat gctgaaacgg gggaaataaa atgacaaaca aagaaaaaga    1980

gttatttgct gaaaatgagg aattaaaaaa agaaattaag gacttaaaag agcgtattga    2040

aagatacaga gaaatggaag ttgaattaag tacaacaata gatttattga gaggagggat    2100

tattgaataa ataaaagccc ccctgacgaa agtcgacatg gactgataaa gtatagtaaa    2160

aacataaaac ggaggatatt gttgtgaaca gagaagagat gactctctta gggtttgaaa    2220

ttgttgctta tgctggagat gctcgctcta agcttttaga agcgcttaaa gcggctgaaa    2280

atggtgattt cgctaaggca gatagtcttg tagtagaagc aggaagctgt attgcagagg    2340

ctcacagttc tcagacaggt atgttggctc gagaagcttc tggggaggaa cttccataca    2400

gtgttactat gatgcatggt caggatcact tgatgactac gatcttatta aaagatgtga    2460

ttcatcacct catcgaactt tataaaagag gagcaaagta attaatgcat aaactcattg    2520

aacttattga gaaagggaaa cgacggatca                                     2550


<210> 36
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="sequencing Primer seqlacF"
      /organism="artificial sequences"

<400> 36
tgtgattcat cacctcatcg                                                20


<210> 37
<211> 21
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..21
<223> /mol_type="DNA"
      /note="Sequencing primer seq2F "
      /organism="artificial sequences"

<400> 37
cgtggctttg cagcgaagat g                                              21


<210> 38
<211> 21
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..21
<223> /mol_type="DNA"
      /note="sequencing primer seq3F "
      /organism="artificial sequences"

<400> 38
gactcaattc ctaatgattg g                                              21


<210> 39
<211> 21
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..21
<223> /mol_type="DNA"
      /note="sequencing primer seq4F"
      /organism="artificial sequences"

<400> 39
tcagtgtgga tatagagcaa g                                              21


<210> 40
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="sequencing primer seq6R "
      /organism="artificial sequences"

<400> 40
ctgtaatttg tttaattgcc                                                20


<210> 41
<211> 20
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..20
<223> /mol_type="DNA"
      /note="sequencing primer seq7R"
      /organism="artificial sequences"

<400> 41
ttgagccagt tgggatagag                                                20


<210> 42
<211> 21
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..21
<223> /mol_type="DNA"
      /note="sequencing primer seq8R "
      /organism="artificial sequences"

<400> 42
gtatctcaac atgagcaact g                                              21


<210> 43
<211> 23
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..23
<223> /mol_type="DNA"
      /note="nis2 sequencing primer"
      /organism="artificial sequences"

<400> 43
caattgaacg tttcaagcct tgg                                            23


<210> 44
<211> 198
<212> DNA
<213> Lactococcus lactis

<220> 
<221> source
<222> 1..198
<223> /mol_type="DNA"
      /note="nisinA promoter"
      /organism="Lactococcus lactis"

<400> 44
tagtcttata actatactga caatagaaac attaacaaat ctaaaacagt cttaattcta     60

tcttgagaaa gtattggtaa taatattatt gtcgataacg cgagcataat aaacggctct    120

gattaaattc tgaagtttgt tagatacaat gatttcgttc gaaggaacta caaaataaat    180

tataaggagg cactcacc                                                  198


<210> 45
<211> 756
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..756
<223> /mol_type="DNA"
      /note="synthetic construct ssUsp45-FGF2-153"
      /organism="artificial sequences"

<400> 45
ggatcctagt cttataacta tactgacaat agaaacatta acaaatctaa aacagtctta      60

attctatctt gagaaagtat tggtaataat attattgtcg ataacgcgag cataataaac     120

ggctctgatt aaattctgaa gtttgttaga tacaatgatt tcgttcgaag gaactacaaa     180

ataaattata aggaggcact caccatgaaa aaaaagatta tctcagctat tttaatgtct     240

acagtgatac tttctgctgc agccccgttg tcaggtgttt acgctgctgg ttccattacg     300

accttgccgg ctttaccaga ggacggaggt tcaggagcct ttccaccagg gcactttaaa     360

gatcccaaac gtctatattg taaaaatgga ggcttctttc tgcgaattca tcctgatgga     420

cgtgtagatg gtgtgcgtga gaaaagtgat cctcatatca aactccaact tcaggcagaa     480

gaaagaggcg tcgtaagtat aaaaggagtt tgcgcgaatc gttacttagc tatgaaagaa     540

gacggtcgat tattggcctc taagtgtgtt actgatgaat gttttttttt tgaacggctt     600

gaatctaata attataacac ttatagaagc agaaaatata catcatggta cgttgcactt     660

aaaaggacag gtcaatataa attagggtct aagacaggac ctggtcaaaa agcaattttg     720

ttcttaccaa tgtcggctaa aagttaataa tctaga                               756


<210> 46
<211> 3066
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..3066
<223> /mol_type="DNA"
      /note="Plasmid pFGF2"
      /organism="artificial sequences"

<400> 46
ggatcctagt cttataacta tactgacaat agaaacatta acaaatctaa aacagtctta      60

attctatctt gagaaagtat tggtaataat attattgtcg ataacgcgag cataataaac     120

ggctctgatt aaattctgaa gtttgttaga tacaatgatt tcgttcgaag gaactacaaa     180

ataaattata aggaggcact caccatgaaa aaaaagatta tctcagctat tttaatgtct     240

acagtgatac tttctgctgc agccccgttg tcaggtgttt acgctgctgg ttccattacg     300

accttgccgg ctttaccaga ggacggaggt tcaggagcct ttccaccagg gcactttaaa     360

gatcccaaac gtctatattg taaaaatgga ggcttctttc tgcgaattca tcctgatgga     420

cgtgtagatg gtgtgcgtga gaaaagtgat cctcatatca aactccaact tcaggcagaa     480

gaaagaggcg tcgtaagtat aaaaggagtt tgcgcgaatc gttacttagc tatgaaagaa     540

gacggtcgat tattggcctc taagtgtgtt actgatgaat gttttttttt tgaacggctt     600

gaatctaata attataacac ttatagaagc agaaaatata catcatggta cgttgcactt     660

aaaaggacag gtcaatataa attagggtct aagacaggac ctggtcaaaa agcaattttg     720

ttcttaccaa tgtcggctaa aagttaataa tctagagagc tcaagctttc tttgaaccaa     780

aattagaaaa ccaaggcttg aaacgttcaa ttgaaatggc aattaaacaa attacagcac     840

gtgttgcttt gattgatagc caaaaagcag cagttgataa agcaattact gatattgctg     900

aaaaattgta atttataaat aaaaatcacc ttttagaggt ggttttttta tttataaatt     960

attcgtttga tttcgctttc gatagaacaa tcaaatcgtt tctgagacgt tttagcgttt    1020

atttcgttta gttatcggca taatcgttaa aacaggcgtt atcgtagcgt aaaagccctt    1080

gagcgtagcg tggctttgca gcgaagatgt tgtctgttag attatgaaag ccgatgactg    1140

aatgaaataa taagcgcagc gtccttctat ttcggttgga ggaggctcaa gggagtttga    1200

gggaatgaaa ttccctcatg ggtttgattt taaaaattgc ttgcaatttt gccgagcggt    1260

agcgctggaa aatttttgaa aaaaatttgg aatttggaaa aaaatggggg gaaaggaagc    1320

gaattttgct tccgtactac gaccccccat taagtgccga gtgccaattt ttgtgccaaa    1380

aacgctctat cccaactggc tcaagggttt gaggggtttt tcaatcgcca acgaatcgcc    1440

aacgttttcg ccaacgtttt ttataaatct atatttaagt agctttattt ttgtttttat    1500

gattacaaag tgatacacta attttataaa attatttgat tggagttttt taaatggtga    1560

tttcagaatc gaaaaaaaga gttatgattt ctctgacaaa agagcaagat aaaaaattaa    1620

cagatatggc gaaacaaaaa gatttttcaa aatctgcggt tgcggcgtta gctatagaag    1680

aatatgcaag aaaggaatca gaacaaaaaa aataagcgaa agctcgcgtt tttagaagga    1740

tacgagtttt cgctacttgt ttttgataag gtaattatat catggctatt aaaaatacta    1800

aagctagaaa ttttggattt ttattatatc ctgactcaat tcctaatgat tggaaagaaa    1860

aattagagag tttgggcgta tctatggctg tcagtccttt acacgatatg gacgaaaaaa    1920

aagataaaga tacatggaat agtagtgatg ttatacgaaa tggaaagcac tataaaaaac    1980

cacactatca cgttatatat attgcacgaa atcctgtaac aatagaaagc gttaggaaca    2040

agattaagcg aaaattgggg aatagttcag ttgctcatgt tgagatactt gattatatca    2100

aaggttcata tgaatatttg actcatgaat caaaggacgc tattgctaag aataaacata    2160

tatacgacaa aaaagatatt ttgaacatta atgattttga tattgaccgc tatataacac    2220

ttgatgaaag ccaaaaaaga gaattgaaga atttactttt agatatagtg gatgactata    2280

atttggtaaa tacaaaagat ttaatggctt ttattcgcct taggggagcg gagtttggaa    2340

ttttaaatac gaatgatgta aaagatattg tttcaacaaa ctctagcgcc tttagattat    2400

ggtttgaggg caattatcag tgtggatata gagcaagtta tgcaaaggtt cttgatgctg    2460

aaacggggga aataaaatga caaacaaaga aaaagagtta tttgctgaaa atgaggaatt    2520

aaaaaaagaa attaaggact taaaagagcg tattgaaaga tacagagaaa tggaagttga    2580

attaagtaca acaatagatt tattgagagg agggattatt gaataaataa aagcccccct    2640

gacgaaagtc gacatggact gataaagtat agtaaaaaca taaaacggag gatattgttg    2700

tgaacagaga agagatgact ctcttagggt ttgaaattgt tgcttatgct ggagatgctc    2760

gctctaagct tttagaagcg cttaaagcgg ctgaaaatgg tgatttcgct aaggcagata    2820

gtcttgtagt agaagcagga agctgtattg cagaggctca cagttctcag acaggtatgt    2880

tggctcgaga agcttctggg gaggaacttc catacagtgt tactatgatg catggtcagg    2940

atcacttgat gactacgatc ttattaaaag atgtgattca tcacctcatc gaactttata    3000

aaagaggagc aaagtaatta atgcataaac tcattgaact tattgagaaa gggaaacgac    3060

ggatca                                                               3066


<210> 47
<211> 687
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..687
<223> /mol_type="DNA"
      /note="synthetic construct ssUsp45-hIL4"
      /organism="artificial sequences"

<400> 47
ggatcctagt cttataacta tactgacaat agaaacatta acaaatctaa aacagtctta      60

attctatctt gagaaagtat tggtaataat attattgtcg ataacgcgag cataataaac     120

ggctctgatt aaattctgaa gtttgttaga tacaatgatt tcgttcgaag gaactacaaa     180

ataaattata aggaggcact caccatgaag aaaaagatta ttagtgcaat tttaatgtca     240

acggtcatct taagcgctgc tgccccattg tcaggtgttt atgcagcaca taagtgtgat     300

ataacattac aagaaattat caaaaccctt aatagtttaa ctgaacagaa gactttgtgt     360

accgaattaa ctgtaactga tatttttgct gcttctaaaa atacaactga aaaagagaca     420

ttttgtcgag ctgccacagt gttaagacaa ttttacagtc atcatgaaaa agacacaaga     480

tgtcttggtg ctacggcaca acaatttcat agacacaaac aacttatccg ttttcttaaa     540

cgtttggatc gtaatctgtg gggcttggca ggattgaaca gttgtcctgt taaagaagcc     600

aatcaatcta ctcttgaaaa tttcttagag agattgaaaa caattatgcg agaaaaatat     660

tctaagtgtt catcttaata atctaga                                         687


<210> 48
<211> 2997
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..2997
<223> /mol_type="DNA"
      /note="Plasmid pIL4"
      /organism="artificial sequences"

<400> 48
ggatcctagt cttataacta tactgacaat agaaacatta acaaatctaa aacagtctta      60

attctatctt gagaaagtat tggtaataat attattgtcg ataacgcgag cataataaac     120

ggctctgatt aaattctgaa gtttgttaga tacaatgatt tcgttcgaag gaactacaaa     180

ataaattata aggaggcact caccatgaag aaaaagatta ttagtgcaat tttaatgtca     240

acggtcatct taagcgctgc tgccccattg tcaggtgttt atgcagcaca taagtgtgat     300

ataacattac aagaaattat caaaaccctt aatagtttaa ctgaacagaa gactttgtgt     360

accgaattaa ctgtaactga tatttttgct gcttctaaaa atacaactga aaaagagaca     420

ttttgtcgag ctgccacagt gttaagacaa ttttacagtc atcatgaaaa agacacaaga     480

tgtcttggtg ctacggcaca acaatttcat agacacaaac aacttatccg ttttcttaaa     540

cgtttggatc gtaatctgtg gggcttggca ggattgaaca gttgtcctgt taaagaagcc     600

aatcaatcta ctcttgaaaa tttcttagag agattgaaaa caattatgcg agaaaaatat     660

tctaagtgtt catcttaata atctagagag ctcaagcttt ctttgaacca aaattagaaa     720

accaaggctt gaaacgttca attgaaatgg caattaaaca aattacagca cgtgttgctt     780

tgattgatag ccaaaaagca gcagttgata aagcaattac tgatattgct gaaaaattgt     840

aatttataaa taaaaatcac cttttagagg tggttttttt atttataaat tattcgtttg     900

atttcgcttt cgatagaaca atcaaatcgt ttctgagacg ttttagcgtt tatttcgttt     960

agttatcggc ataatcgtta aaacaggcgt tatcgtagcg taaaagccct tgagcgtagc    1020

gtggctttgc agcgaagatg ttgtctgtta gattatgaaa gccgatgact gaatgaaata    1080

ataagcgcag cgtccttcta tttcggttgg aggaggctca agggagtttg agggaatgaa    1140

attccctcat gggtttgatt ttaaaaattg cttgcaattt tgccgagcgg tagcgctgga    1200

aaatttttga aaaaaatttg gaatttggaa aaaaatgggg ggaaaggaag cgaattttgc    1260

ttccgtacta cgacccccca ttaagtgccg agtgccaatt tttgtgccaa aaacgctcta    1320

tcccaactgg ctcaagggtt tgaggggttt ttcaatcgcc aacgaatcgc caacgttttc    1380

gccaacgttt tttataaatc tatatttaag tagctttatt tttgttttta tgattacaaa    1440

gtgatacact aattttataa aattatttga ttggagtttt ttaaatggtg atttcagaat    1500

cgaaaaaaag agttatgatt tctctgacaa aagagcaaga taaaaaatta acagatatgg    1560

cgaaacaaaa agatttttca aaatctgcgg ttgcggcgtt agctatagaa gaatatgcaa    1620

gaaaggaatc agaacaaaaa aaataagcga aagctcgcgt ttttagaagg atacgagttt    1680

tcgctacttg tttttgataa ggtaattata tcatggctat taaaaatact aaagctagaa    1740

attttggatt tttattatat cctgactcaa ttcctaatga ttggaaagaa aaattagaga    1800

gtttgggcgt atctatggct gtcagtcctt tacacgatat ggacgaaaaa aaagataaag    1860

atacatggaa tagtagtgat gttatacgaa atggaaagca ctataaaaaa ccacactatc    1920

acgttatata tattgcacga aatcctgtaa caatagaaag cgttaggaac aagattaagc    1980

gaaaattggg gaatagttca gttgctcatg ttgagatact tgattatatc aaaggttcat    2040

atgaatattt gactcatgaa tcaaaggacg ctattgctaa gaataaacat atatacgaca    2100

aaaaagatat tttgaacatt aatgattttg atattgaccg ctatataaca cttgatgaaa    2160

gccaaaaaag agaattgaag aatttacttt tagatatagt ggatgactat aatttggtaa    2220

atacaaaaga tttaatggct tttattcgcc ttaggggagc ggagtttgga attttaaata    2280

cgaatgatgt aaaagatatt gtttcaacaa actctagcgc ctttagatta tggtttgagg    2340

gcaattatca gtgtggatat agagcaagtt atgcaaaggt tcttgatgct gaaacggggg    2400

aaataaaatg acaaacaaag aaaaagagtt atttgctgaa aatgaggaat taaaaaaaga    2460

aattaaggac ttaaaagagc gtattgaaag atacagagaa atggaagttg aattaagtac    2520

aacaatagat ttattgagag gagggattat tgaataaata aaagcccccc tgacgaaagt    2580

cgacatggac tgataaagta tagtaaaaac ataaaacgga ggatattgtt gtgaacagag    2640

aagagatgac tctcttaggg tttgaaattg ttgcttatgc tggagatgct cgctctaagc    2700

ttttagaagc gcttaaagcg gctgaaaatg gtgatttcgc taaggcagat agtcttgtag    2760

tagaagcagg aagctgtatt gcagaggctc acagttctca gacaggtatg ttggctcgag    2820

aagcttctgg ggaggaactt ccatacagtg ttactatgat gcatggtcag gatcacttga    2880

tgactacgat cttattaaaa gatgtgattc atcacctcat cgaactttat aaaagaggag    2940

caaagtaatt aatgcataaa ctcattgaac ttattgagaa agggaaacga cggatca       2997


<210> 49
<211> 774
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..774
<223> /mol_type="DNA"
      /note="synthetic construct ssUsp45-hCSF1"
      /organism="artificial sequences"

<400> 49
ggatcctagt cttataacta tactgacaat agaaacatta acaaatctaa aacagtctta      60

attctatctt gagaaagtat tggtaataat attattgtcg ataacgcgag cataataaac     120

ggctctgatt aaattctgaa gtttgttaga tacaatgatt tcgttcgaag gaactacaaa     180

ataaattata aggaggcact caccatgaaa aagaaaatca tttcagcgat tttgatgtca     240

acggttattt taagcgcagc agctccatta tctggagttt atgcagcaga agaagttagt     300

gagtactgta gtcatatgat tggttctgga cacttacaat cacttcagcg tcttattgat     360

agtcaaatgg aaacctcttg tcaaattaca tttgaatttg tagaccaaga acaacttaaa     420

gatccagtat gttatcttaa gaaagctttt cttttagtcc aagacataat ggaagataca     480

atgagattca gagacaatac tcctaacgct atcgccattg tccaattaca agaactttct     540

ttaagattga aaagttgctt cactaaagat tatgaggaac atgataaagc ttgtgttcga     600

acattttatg aaactccttt gcaattattg gaaaaagtga aaaatgtttt caatgagacg     660

aagaatttgt tggataaaga ttggaatata ttcagtaaga attgtaataa ctcatttgcc     720

gaatgttcaa gccagggtca tgaacgtcaa tcagaaggct cttaataatc taga           774


<210> 50
<211> 3084
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..3084
<223> /mol_type="DNA"
      /note="Plasmid pCSF1"
      /organism="artificial sequences"

<400> 50
ggatcctagt cttataacta tactgacaat agaaacatta acaaatctaa aacagtctta      60

attctatctt gagaaagtat tggtaataat attattgtcg ataacgcgag cataataaac     120

ggctctgatt aaattctgaa gtttgttaga tacaatgatt tcgttcgaag gaactacaaa     180

ataaattata aggaggcact caccatgaaa aagaaaatca tttcagcgat tttgatgtca     240

acggttattt taagcgcagc agctccatta tctggagttt atgcagcaga agaagttagt     300

gagtactgta gtcatatgat tggttctgga cacttacaat cacttcagcg tcttattgat     360

agtcaaatgg aaacctcttg tcaaattaca tttgaatttg tagaccaaga acaacttaaa     420

gatccagtat gttatcttaa gaaagctttt cttttagtcc aagacataat ggaagataca     480

atgagattca gagacaatac tcctaacgct atcgccattg tccaattaca agaactttct     540

ttaagattga aaagttgctt cactaaagat tatgaggaac atgataaagc ttgtgttcga     600

acattttatg aaactccttt gcaattattg gaaaaagtga aaaatgtttt caatgagacg     660

aagaatttgt tggataaaga ttggaatata ttcagtaaga attgtaataa ctcatttgcc     720

gaatgttcaa gccagggtca tgaacgtcaa tcagaaggct cttaataatc tagagagctc     780

aagctttctt tgaaccaaaa ttagaaaacc aaggcttgaa acgttcaatt gaaatggcaa     840

ttaaacaaat tacagcacgt gttgctttga ttgatagcca aaaagcagca gttgataaag     900

caattactga tattgctgaa aaattgtaat ttataaataa aaatcacctt ttagaggtgg     960

tttttttatt tataaattat tcgtttgatt tcgctttcga tagaacaatc aaatcgtttc    1020

tgagacgttt tagcgtttat ttcgtttagt tatcggcata atcgttaaaa caggcgttat    1080

cgtagcgtaa aagcccttga gcgtagcgtg gctttgcagc gaagatgttg tctgttagat    1140

tatgaaagcc gatgactgaa tgaaataata agcgcagcgt ccttctattt cggttggagg    1200

aggctcaagg gagtttgagg gaatgaaatt ccctcatggg tttgatttta aaaattgctt    1260

gcaattttgc cgagcggtag cgctggaaaa tttttgaaaa aaatttggaa tttggaaaaa    1320

aatgggggga aaggaagcga attttgcttc cgtactacga ccccccatta agtgccgagt    1380

gccaattttt gtgccaaaaa cgctctatcc caactggctc aagggtttga ggggtttttc    1440

aatcgccaac gaatcgccaa cgttttcgcc aacgtttttt ataaatctat atttaagtag    1500

ctttattttt gtttttatga ttacaaagtg atacactaat tttataaaat tatttgattg    1560

gagtttttta aatggtgatt tcagaatcga aaaaaagagt tatgatttct ctgacaaaag    1620

agcaagataa aaaattaaca gatatggcga aacaaaaaga tttttcaaaa tctgcggttg    1680

cggcgttagc tatagaagaa tatgcaagaa aggaatcaga acaaaaaaaa taagcgaaag    1740

ctcgcgtttt tagaaggata cgagttttcg ctacttgttt ttgataaggt aattatatca    1800

tggctattaa aaatactaaa gctagaaatt ttggattttt attatatcct gactcaattc    1860

ctaatgattg gaaagaaaaa ttagagagtt tgggcgtatc tatggctgtc agtcctttac    1920

acgatatgga cgaaaaaaaa gataaagata catggaatag tagtgatgtt atacgaaatg    1980

gaaagcacta taaaaaacca cactatcacg ttatatatat tgcacgaaat cctgtaacaa    2040

tagaaagcgt taggaacaag attaagcgaa aattggggaa tagttcagtt gctcatgttg    2100

agatacttga ttatatcaaa ggttcatatg aatatttgac tcatgaatca aaggacgcta    2160

ttgctaagaa taaacatata tacgacaaaa aagatatttt gaacattaat gattttgata    2220

ttgaccgcta tataacactt gatgaaagcc aaaaaagaga attgaagaat ttacttttag    2280

atatagtgga tgactataat ttggtaaata caaaagattt aatggctttt attcgcctta    2340

ggggagcgga gtttggaatt ttaaatacga atgatgtaaa agatattgtt tcaacaaact    2400

ctagcgcctt tagattatgg tttgagggca attatcagtg tggatataga gcaagttatg    2460

caaaggttct tgatgctgaa acgggggaaa taaaatgaca aacaaagaaa aagagttatt    2520

tgctgaaaat gaggaattaa aaaaagaaat taaggactta aaagagcgta ttgaaagata    2580

cagagaaatg gaagttgaat taagtacaac aatagattta ttgagaggag ggattattga    2640

ataaataaaa gcccccctga cgaaagtcga catggactga taaagtatag taaaaacata    2700

aaacggagga tattgttgtg aacagagaag agatgactct cttagggttt gaaattgttg    2760

cttatgctgg agatgctcgc tctaagcttt tagaagcgct taaagcggct gaaaatggtg    2820

atttcgctaa ggcagatagt cttgtagtag aagcaggaag ctgtattgca gaggctcaca    2880

gttctcagac aggtatgttg gctcgagaag cttctgggga ggaacttcca tacagtgtta    2940

ctatgatgca tggtcaggat cacttgatga ctacgatctt attaaaagat gtgattcatc    3000

acctcatcga actttataaa agaggagcaa agtaattaat gcataaactc attgaactta    3060

ttgagaaagg gaaacgacgg atca                                           3084


<210> 51
<211> 27
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..27
<223> /mol_type="DNA"
      /note="nisA ribosome binding site"
      /organism="artificial sequences"

<400> 51
ataaattata aggaggcact caccatg                                        27


<210> 52
<211> 24
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..24
<223> /mol_type="DNA"
      /note="atpG ribosome binding site"
      /organism="artificial sequences"

<400> 52
tattaataag gaggctaact aatg                                           24


<210> 53
<211> 23
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..23
<223> /mol_type="DNA"
      /note="lacA ribosome binding site"
      /organism="artificial sequences"

<400> 53
aaatttagga ggtagtccaa atg                                            23


<210> 54
<211> 16
<212> RNA
<213> artificial sequences

<220> 
<221> source
<222> 1..16
<223> /mol_type="RNA"
      /note="3 prime end of 16S ribosomal DNA "
      /organism="artificial sequences"

<400> 54
ggaucaccuc cuuucu                                                    16


<210> 55
<211> 1850
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..1850
<223> /mol_type="DNA"
      /note="synthetic construct CSF-RBS1-FGF-RBS2-IL4"
      /organism="artificial sequences"

<400> 55
ggatcctagt cttataacta tactgacaat agaaacatta acaaatctaa aacagtctta      60

attctatctt gagaaagtat tggtaataat attattgtcg ataacgcgag cataataaac     120

ggctctgatt aaattctgaa gtttgttaga tacaatgatt tcgttcgaag gaactacaaa     180

ataaattata aggaggcact caccatgaaa aagaaaatca tttcagcgat tttgatgtca     240

acggttattt taagcgcagc agctccatta tctggagttt atgcagcaga agaagttagt     300

gagtactgta gtcatatgat tggttctgga cacttacaat cacttcagcg tcttattgat     360

agtcaaatgg aaacctcttg tcaaattaca tttgaatttg tagaccaaga acaacttaaa     420

gatccagtat gttatcttaa gaaagctttt cttttagtcc aagacataat ggaagataca     480

atgagattca gagacaatac tcctaacgct atcgccattg tccaattaca agaactttct     540

ttaagattga aaagttgctt cactaaagat tatgaggaac atgataaagc ttgtgttcga     600

acattttatg aaactccttt gcaattattg gaaaaagtga aaaatgtttt caatgagacg     660

aagaatttgt tggataaaga ttggaatata ttcagtaaga attgtaataa ctcatttgcc     720

gaatgttcaa gccagggtca tgaacgtcaa tcagaaggct cttaataaac gcgtattaat     780

aaggaggcta actaatgaaa aaaaagatta tctcagctat tttaatgtct acagtgatac     840

tttctgctgc agccccgttg tcaggtgttt acgctgctgg ttccattacg accttgccgg     900

ctttaccaga ggacggaggt tcaggagcct ttccaccagg gcactttaaa gatcccaaac     960

gtctatattg taaaaatgga ggcttctttc tgcgaattca tcctgatgga cgtgtagatg    1020

gtgtgcgtga gaaaagtgat cctcatatca aactccaact tcaggcagaa gaaagaggcg    1080

tcgtaagtat aaaaggagtt tgcgcgaatc gttacttagc tatgaaagaa gacggtcgat    1140

tattggcctc taagtgtgtt actgatgaat gttttttttt tgaacggctt gaatctaata    1200

attataacac ttatagaagc agaaaatata catcatggta cgttgcactt aaaaggacag    1260

gtcaatataa attagggtct aagacaggac ctggtcaaaa agcaattttg ttcttaccaa    1320

tgtcggctaa aagttaataa acgcgtgaaa tttaggaggt agtccaaatg aagaaaaaga    1380

ttattagtgc aattttaatg tcaacggtca tcttaagcgc tgctgcccca ttgtcaggtg    1440

tttatgcagc acataagtgt gatataacat tacaagaaat tatcaaaacc cttaatagtt    1500

taactgaaca gaagactttg tgtaccgaat taactgtaac tgatattttt gctgcttcta    1560

aaaatacaac tgaaaaagag acattttgtc gagctgccac agtgttaaga caattttaca    1620

gtcatcatga aaaagacaca agatgtcttg gtgctacggc acaacaattt catagacaca    1680

aacaacttat ccgttttctt aaacgtttgg atcgtaatct gtggggcttg gcaggattga    1740

acagttgtcc tgttaaagaa gccaatcaat ctactcttga aaatttctta gagagattga    1800

aaacaattat gcgagaaaaa tattctaagt gttcatctta ataaccatgg               1850


<210> 56
<211> 1850
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..1850
<223> /mol_type="DNA"
      /note="synthetic construct FGF-RBS1-IL4-RBS2-CSF"
      /organism="artificial sequences"

<400> 56
ggatcctagt cttataacta tactgacaat agaaacatta acaaatctaa aacagtctta      60

attctatctt gagaaagtat tggtaataat attattgtcg ataacgcgag cataataaac     120

ggctctgatt aaattctgaa gtttgttaga tacaatgatt tcgttcgaag gaactacaaa     180

ataaattata aggaggcact caccatgaaa aaaaagatta tctcagctat tttaatgtct     240

acagtgatac tttctgctgc agccccgttg tcaggtgttt acgctgctgg ttccattacg     300

accttgccgg ctttaccaga ggacggaggt tcaggagcct ttccaccagg gcactttaaa     360

gatcccaaac gtctatattg taaaaatgga ggcttctttc tgcgaattca tcctgatgga     420

cgtgtagatg gtgtgcgtga gaaaagtgat cctcatatca aactccaact tcaggcagaa     480

gaaagaggcg tcgtaagtat aaaaggagtt tgcgcgaatc gttacttagc tatgaaagaa     540

gacggtcgat tattggcctc taagtgtgtt actgatgaat gttttttttt tgaacggctt     600

gaatctaata attataacac ttatagaagc agaaaatata catcatggta cgttgcactt     660

aaaaggacag gtcaatataa attagggtct aagacaggac ctggtcaaaa agcaattttg     720

ttcttaccaa tgtcggctaa aagttaataa acgcgtatta ataaggaggc taactaatga     780

agaaaaagat tattagtgca attttaatgt caacggtcat cttaagcgct gctgccccat     840

tgtcaggtgt ttatgcagca cataagtgtg atataacatt acaagaaatt atcaaaaccc     900

ttaatagttt aactgaacag aagactttgt gtaccgaatt aactgtaact gatatttttg     960

ctgcttctaa aaatacaact gaaaaagaga cattttgtcg agctgccaca gtgttaagac    1020

aattttacag tcatcatgaa aaagacacaa gatgtcttgg tgctacggca caacaatttc    1080

atagacacaa acaacttatc cgttttctta aacgtttgga tcgtaatctg tggggcttgg    1140

caggattgaa cagttgtcct gttaaagaag ccaatcaatc tactcttgaa aatttcttag    1200

agagattgaa aacaattatg cgagaaaaat attctaagtg ttcatcttaa taaacgcgtg    1260

aaatttagga ggtagtccaa atgaaaaaga aaatcatttc agcgattttg atgtcaacgg    1320

ttattttaag cgcagcagct ccattatctg gagtttatgc agcagaagaa gttagtgagt    1380

actgtagtca tatgattggt tctggacact tacaatcact tcagcgtctt attgatagtc    1440

aaatggaaac ctcttgtcaa attacatttg aatttgtaga ccaagaacaa cttaaagatc    1500

cagtatgtta tcttaagaaa gcttttcttt tagtccaaga cataatggaa gatacaatga    1560

gattcagaga caatactcct aacgctatcg ccattgtcca attacaagaa ctttctttaa    1620

gattgaaaag ttgcttcact aaagattatg aggaacatga taaagcttgt gttcgaacat    1680

tttatgaaac tcctttgcaa ttattggaaa aagtgaaaaa tgttttcaat gagacgaaga    1740

atttgttgga taaagattgg aatatattca gtaagaattg taataactca tttgccgaat    1800

gttcaagcca gggtcatgaa cgtcaatcag aaggctctta ataaccatgg               1850


<210> 57
<211> 1850
<212> DNA
<213> artificial sequences

<220> 
<221> source
<222> 1..1850
<223> /mol_type="DNA"
      /note="synthetic construct IL4-RBS1-CSF-RBS2-FGF"
      /organism="artificial sequences"

<400> 57
ggatcctagt cttataacta tactgacaat agaaacatta acaaatctaa aacagtctta      60

attctatctt gagaaagtat tggtaataat attattgtcg ataacgcgag cataataaac     120

ggctctgatt aaattctgaa gtttgttaga tacaatgatt tcgttcgaag gaactacaaa     180

ataaattata aggaggcact caccatgaag aaaaagatta ttagtgcaat tttaatgtca     240

acggtcatct taagcgctgc tgccccattg tcaggtgttt atgcagcaca taagtgtgat     300

ataacattac aagaaattat caaaaccctt aatagtttaa ctgaacagaa gactttgtgt     360

accgaattaa ctgtaactga tatttttgct gcttctaaaa atacaactga aaaagagaca     420

ttttgtcgag ctgccacagt gttaagacaa ttttacagtc atcatgaaaa agacacaaga     480

tgtcttggtg ctacggcaca acaatttcat agacacaaac aacttatccg ttttcttaaa     540

cgtttggatc gtaatctgtg gggcttggca ggattgaaca gttgtcctgt taaagaagcc     600

aatcaatcta ctcttgaaaa tttcttagag agattgaaaa caattatgcg agaaaaatat     660

tctaagtgtt catcttaata aacgcgtatt aataaggagg ctaactaatg aaaaagaaaa     720

tcatttcagc gattttgatg tcaacggtta ttttaagcgc agcagctcca ttatctggag     780

tttatgcagc agaagaagtt agtgagtact gtagtcatat gattggttct ggacacttac     840

aatcacttca gcgtcttatt gatagtcaaa tggaaacctc ttgtcaaatt acatttgaat     900

ttgtagacca agaacaactt aaagatccag tatgttatct taagaaagct tttcttttag     960

tccaagacat aatggaagat acaatgagat tcagagacaa tactcctaac gctatcgcca    1020

ttgtccaatt acaagaactt tctttaagat tgaaaagttg cttcactaaa gattatgagg    1080

aacatgataa agcttgtgtt cgaacatttt atgaaactcc tttgcaatta ttggaaaaag    1140

tgaaaaatgt tttcaatgag acgaagaatt tgttggataa agattggaat atattcagta    1200

agaattgtaa taactcattt gccgaatgtt caagccaggg tcatgaacgt caatcagaag    1260

gctcttaata aacgcgtgaa atttaggagg tagtccaaat gaaaaaaaag attatctcag    1320

ctattttaat gtctacagtg atactttctg ctgcagcccc gttgtcaggt gtttacgctg    1380

ctggttccat tacgaccttg ccggctttac cagaggacgg aggttcagga gcctttccac    1440

cagggcactt taaagatccc aaacgtctat attgtaaaaa tggaggcttc tttctgcgaa    1500

ttcatcctga tggacgtgta gatggtgtgc gtgagaaaag tgatcctcat atcaaactcc    1560

aacttcaggc agaagaaaga ggcgtcgtaa gtataaaagg agtttgcgcg aatcgttact    1620

tagctatgaa agaagacggt cgattattgg cctctaagtg tgttactgat gaatgttttt    1680

tttttgaacg gcttgaatct aataattata acacttatag aagcagaaaa tatacatcat    1740

ggtacgttgc acttaaaagg acaggtcaat ataaattagg gtctaagaca ggacctggtc    1800

aaaaagcaat tttgttctta ccaatgtcgg ctaaaagtta ataaccatgg               1850


<210> 58
<211> 1207
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1207
<223> /mol_type="protein"
      /note="epidermal growth factor isoform 1 preproprotein "
      /organism="Homo sapiens"

<400> 58
Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                   15    
Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                   25                  30        
Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                   40                  45            
Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                   55                  60                
Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                   70                  75                  80
Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                   90                  95    
Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                  105                110        
Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                  120                125            
Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                  135                140                
Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                  150                155                  160
Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                  170                175    
Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                  185                190        
Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                  200                205            
Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                  215                220                
Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                  230                235                  240
Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                  250                255    
Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                  265                270        
Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                  280                285            
Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                  295                300                
Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                  310                315                  320
Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                  330                335    
His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                  345                350        
Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                  360                365            
Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                  375                380                
Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                  390                395                  400
Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                  410                415    
Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                  425                430        
Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                  440                445            
Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                  455                460                
Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                  470                475                  480
Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                  490                495    
His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                  505                510        
Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                  520                525            
Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                  535                540                
Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                  550                555                  560
Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                  570                575    
Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                  585                590        
Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                  600                605            
Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                  615                620                
Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                  630                635                  640
Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                  650                655    
Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                  665                670        
Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                  680                685            
Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                  695                700                
Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                  710                715                  720
Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                  730                735    
Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                  745                750        
Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                  760                765            
Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                  775                780                
Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                  790                795                  800
Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                  810                815    
Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                  825                830        
Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                  840                845            
Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                  855                860                
Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                  870                875                  880
Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                  890                895    
Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                  905                910        
Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                  920                925            
Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                  935                940                
Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                  950                955                  960
Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                  970                975    
Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                  985                990        
Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn Cys Val Val Gly Tyr Ile 
        995                  1000                1005            
Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys Trp Trp Glu Leu Arg His 
    1010                1015                1020                
Ala Gly His Gly Gln Gln Gln Lys Val Ile Val Val Ala Val Cys Val 
1025                1030                1035                1040
Val Val Leu Val Met Leu Leu Leu Leu Ser Leu Trp Gly Ala His Tyr 
                1045                1050                1055    
Tyr Arg Thr Gln Lys Leu Leu Ser Lys Asn Pro Lys Asn Pro Tyr Glu 
            1060                1065                1070        
Glu Ser Ser Arg Asp Val Arg Ser Arg Arg Pro Ala Asp Thr Glu Asp 
        1075                1080                1085            
Gly Met Ser Ser Cys Pro Gln Pro Trp Phe Val Val Ile Lys Glu His 
    1090                1095                1100                
Gln Asp Leu Lys Asn Gly Gly Gln Pro Val Ala Gly Glu Asp Gly Gln 
1105                1110                1115                1120
Ala Ala Asp Gly Ser Met Gln Pro Thr Ser Trp Arg Gln Glu Pro Gln 
                1125                1130                1135    
Leu Cys Gly Met Gly Thr Glu Gln Gly Cys Trp Ile Pro Val Ser Ser 
            1140                1145                1150        
Asp Lys Gly Ser Cys Pro Gln Val Met Glu Arg Ser Phe His Met Pro 
        1155                1160                1165            
Ser Tyr Gly Thr Gln Thr Leu Glu Gly Gly Val Glu Lys Pro His Ser 
    1170                1175                1180                
Leu Leu Ser Ala Asn Pro Leu Trp Gln Gln Arg Ala Leu Asp Pro Pro 
1185                1190                1195                1200
His Gln Met Glu Leu Thr Gln 
                1205        

<210> 59
<211> 1165
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1165
<223> /mol_type="protein"
      /note="epidermal growth factor isoform 2 preproprotein "
      /organism="Homo sapiens"

<400> 59
Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                   15    
Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                   25                  30        
Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                   40                  45            
Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                   55                  60                
Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                   70                  75                  80
Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                   90                  95    
Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                  105                110        
Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                  120                125            
Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                  135                140                
Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                  150                155                  160
Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                  170                175    
Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                  185                190        
Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                  200                205            
Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                  215                220                
Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                  230                235                  240
Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                  250                255    
Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                  265                270        
Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                  280                285            
Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                  295                300                
Lys Ala Glu Asp Asp Thr Trp Glu Pro Asp Val Asn Glu Cys Ala Phe 
305                  310                315                  320
Trp Asn His Gly Cys Thr Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr 
                325                  330                335    
Tyr Cys Thr Cys Pro Val Gly Phe Val Leu Leu Pro Asp Gly Lys Arg 
            340                  345                350        
Cys His Gln Leu Val Ser Cys Pro Arg Asn Val Ser Glu Cys Ser His 
        355                  360                365            
Asp Cys Val Leu Thr Ser Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly 
    370                  375                380                
Ser Val Leu Glu Arg Asp Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro 
385                  390                395                  400
Asp Asn Gly Gly Cys Ser Gln Leu Cys Val Pro Leu Ser Pro Val Ser 
                405                  410                415    
Trp Glu Cys Asp Cys Phe Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys 
            420                  425                430        
Ser Cys Ala Ala Ser Gly Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser 
        435                  440                445            
Gln Asp Ile Arg His Met His Phe Asp Gly Thr Asp Tyr Gly Thr Leu 
    450                  455                460                
Leu Ser Gln Gln Met Gly Met Val Tyr Ala Leu Asp His Asp Pro Val 
465                  470                475                  480
Glu Asn Lys Ile Tyr Phe Ala His Thr Ala Leu Lys Trp Ile Glu Arg 
                485                  490                495    
Ala Asn Met Asp Gly Ser Gln Arg Glu Arg Leu Ile Glu Glu Gly Val 
            500                  505                510        
Asp Val Pro Glu Gly Leu Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr 
        515                  520                525            
Trp Thr Asp Arg Gly Lys Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly 
    530                  535                540                
Lys Arg Ser Lys Ile Ile Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly 
545                  550                555                  560
Ile Ala Val His Pro Met Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly 
                565                  570                575    
Ile Asn Pro Arg Ile Glu Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu 
            580                  585                590        
Val Ile Ala Ser Ser Asp Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp 
        595                  600                605            
Phe Leu Thr Asp Lys Leu Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile 
    610                  615                620                
Glu Met Ala Asn Leu Asp Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn 
625                  630                635                  640
Asp Val Gly His Pro Phe Ala Val Ala Val Phe Glu Asp Tyr Val Trp 
                645                  650                655    
Phe Ser Asp Trp Ala Met Pro Ser Val Met Arg Val Asn Lys Arg Thr 
            660                  665                670        
Gly Lys Asp Arg Val Arg Leu Gln Gly Ser Met Leu Lys Pro Ser Ser 
        675                  680                685            
Leu Val Val Val His Pro Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu 
    690                  695                700                
Tyr Gln Asn Gly Gly Cys Glu His Ile Cys Lys Lys Arg Leu Gly Thr 
705                  710                715                  720
Ala Trp Cys Ser Cys Arg Glu Gly Phe Met Lys Ala Ser Asp Gly Lys 
                725                  730                735    
Thr Cys Leu Ala Leu Asp Gly His Gln Leu Leu Ala Gly Gly Glu Val 
            740                  745                750        
Asp Leu Lys Asn Gln Val Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg 
        755                  760                765            
Val Ser Glu Asp Asn Ile Thr Glu Ser Gln His Met Leu Val Ala Glu 
    770                  775                780                
Ile Met Val Ser Asp Gln Asp Asp Cys Ala Pro Val Gly Cys Ser Met 
785                  790                795                  800
Tyr Ala Arg Cys Ile Ser Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu 
                805                  810                815    
Lys Gly Phe Ala Gly Asp Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys 
            820                  825                830        
Glu Met Gly Val Pro Val Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn 
        835                  840                845            
Thr Glu Gly Gly Tyr Val Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp 
    850                  855                860                
Gly Ile His Cys Leu Asp Ile Asp Glu Cys Gln Leu Gly Glu His Ser 
865                  870                875                  880
Cys Gly Glu Asn Ala Ser Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys 
                885                  890                895    
Met Cys Ala Gly Arg Leu Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser 
            900                  905                910        
Thr Pro Pro Pro His Leu Arg Glu Asp Asp His His Tyr Ser Val Arg 
        915                  920                925            
Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
    930                  935                940                
Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
945                  950                955                  960
Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
                965                  970                975    
Trp Trp Glu Leu Arg His Ala Gly His Gly Gln Gln Gln Lys Val Ile 
            980                  985                990        
Val Val Ala Val Cys Val Val Val Leu Val Met Leu Leu Leu Leu Ser 
        995                  1000                1005            
Leu Trp Gly Ala His Tyr Tyr Arg Thr Gln Lys Leu Leu Ser Lys Asn 
    1010                1015                1020                
Pro Lys Asn Pro Tyr Glu Glu Ser Ser Arg Asp Val Arg Ser Arg Arg 
1025                1030                1035                1040
Pro Ala Asp Thr Glu Asp Gly Met Ser Ser Cys Pro Gln Pro Trp Phe 
                1045                1050                1055    
Val Val Ile Lys Glu His Gln Asp Leu Lys Asn Gly Gly Gln Pro Val 
            1060                1065                1070        
Ala Gly Glu Asp Gly Gln Ala Ala Asp Gly Ser Met Gln Pro Thr Ser 
        1075                1080                1085            
Trp Arg Gln Glu Pro Gln Leu Cys Gly Met Gly Thr Glu Gln Gly Cys 
    1090                1095                1100                
Trp Ile Pro Val Ser Ser Asp Lys Gly Ser Cys Pro Gln Val Met Glu 
1105                1110                1115                1120
Arg Ser Phe His Met Pro Ser Tyr Gly Thr Gln Thr Leu Glu Gly Gly 
                1125                1130                1135    
Val Glu Lys Pro His Ser Leu Leu Ser Ala Asn Pro Leu Trp Gln Gln 
            1140                1145                1150        
Arg Ala Leu Asp Pro Pro His Gln Met Glu Leu Thr Gln 
        1155                1160                1165

<210> 60
<211> 1166
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1166
<223> /mol_type="protein"
      /note="epidermal growth factor isoform 3 preproprotein "
      /organism="Homo sapiens"

<400> 60
Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                   15    
Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                   25                  30        
Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                   40                  45            
Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                   55                  60                
Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                   70                  75                  80
Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                   90                  95    
Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                  105                110        
Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                  120                125            
Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                  135                140                
Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                  150                155                  160
Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                  170                175    
Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                  185                190        
Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                  200                205            
Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                  215                220                
Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                  230                235                  240
Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                  250                255    
Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                  265                270        
Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                  280                285            
Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                  295                300                
Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                  310                315                  320
Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                  330                335    
His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                  345                350        
Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                  360                365            
Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                  375                380                
Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                  390                395                  400
Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                  410                415    
Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                  425                430        
Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                  440                445            
Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                  455                460                
Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                  470                475                  480
Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                  490                495    
His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                  505                510        
Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                  520                525            
Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                  535                540                
Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                  550                555                  560
Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                  570                575    
Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                  585                590        
Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                  600                605            
Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                  615                620                
Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                  630                635                  640
Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                  650                655    
Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                  665                670        
Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                  680                685            
Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                  695                700                
Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                  710                715                  720
Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                  730                735    
Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                  745                750        
Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                  760                765            
Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                  775                780                
Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                  790                795                  800
Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                  810                815    
Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                  825                830        
Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                  840                845            
Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                  855                860                
Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                  870                875                  880
Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                  890                895    
Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                  905                910        
Ser Thr Pro Pro Pro His Leu Arg Glu Asp Asp His His Tyr Ser Val 
        915                  920                925            
Arg Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu 
    930                  935                940                
His Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys 
945                  950                955                  960
Asn Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu 
                965                  970                975    
Lys Trp Trp Glu Leu Arg His Ala Gly His Gly Gln Gln Gln Lys Val 
            980                  985                990        
Ile Val Val Ala Val Cys Val Val Val Leu Val Met Leu Leu Leu Leu 
        995                  1000                1005            
Ser Leu Trp Gly Ala His Tyr Tyr Arg Thr Gln Lys Leu Leu Ser Lys 
    1010                1015                1020                
Asn Pro Lys Asn Pro Tyr Glu Glu Ser Ser Arg Asp Val Arg Ser Arg 
1025                1030                1035                1040
Arg Pro Ala Asp Thr Glu Asp Gly Met Ser Ser Cys Pro Gln Pro Trp 
                1045                1050                1055    
Phe Val Val Ile Lys Glu His Gln Asp Leu Lys Asn Gly Gly Gln Pro 
            1060                1065                1070        
Val Ala Gly Glu Asp Gly Gln Ala Ala Asp Gly Ser Met Gln Pro Thr 
        1075                1080                1085            
Ser Trp Arg Gln Glu Pro Gln Leu Cys Gly Met Gly Thr Glu Gln Gly 
    1090                1095                1100                
Cys Trp Ile Pro Val Ser Ser Asp Lys Gly Ser Cys Pro Gln Val Met 
1105                1110                1115                1120
Glu Arg Ser Phe His Met Pro Ser Tyr Gly Thr Gln Thr Leu Glu Gly 
                1125                1130                1135    
Gly Val Glu Lys Pro His Ser Leu Leu Ser Ala Asn Pro Leu Trp Gln 
            1140                1145                1150        
Gln Arg Ala Leu Asp Pro Pro His Gln Met Glu Leu Thr Gln 
        1155                1160                1165    

<210> 61
<211> 53
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..53
<223> /mol_type="protein"
      /note="mature epidermal growth factor"
      /organism="Homo sapiens"

<400> 61
Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                   15    
Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                   25                  30        
Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                   40                  45            
Trp Trp Glu Leu Arg 
    50            

<210> 62
<211> 208
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..208
<223> /mol_type="protein"
      /note="heparin-binding EGF-like growth factor precursor"
      /organism="Homo sapiens"

<400> 62
Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                   15    
Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                   25                  30        
Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
        35                   40                  45            
Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
    50                   55                  60                
Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
65                   70                  75                  80
Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                85                   90                  95    
Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                  105                110        
Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
        115                  120                125            
Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
    130                  135                140                
Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
145                  150                155                  160
Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                  170                175    
Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                  185                190        
Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
        195                  200                205            

<210> 63
<211> 86
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..86
<223> /mol_type="protein"
      /note="mature heparin-binding EGF-like growth factor"
      /organism="Homo sapiens"

<400> 63
Asp Leu Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser 
1               5                   10                   15    
Lys Pro Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg 
            20                   25                  30        
Lys Lys Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg 
        35                   40                  45            
Lys Tyr Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu 
    50                   55                  60                
Leu Arg Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg 
65                   70                  75                  80
Cys His Gly Leu Ser Leu 
                85    

<210> 64
<211> 160
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..160
<223> /mol_type="protein"
      /note="transforming growth factor alpha isoform 1 preproprotein"
      /organism="Homo sapiens"

<400> 64
Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                   15    
Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala 
            20                   25                  30        
Asp Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro 
        35                   40                  45            
Asp Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val 
    50                   55                  60                
Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala 
65                   70                  75                  80
Arg Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys 
                85                   90                  95    
Lys Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala 
            100                  105                110        
Val Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys 
        115                  120                125            
His Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser 
    130                  135                140                
Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                  150                155                  160

<210> 65
<211> 159
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..159
<223> /mol_type="protein"
      /note="transforming growth factor alpha isoform 2 preproprotein"
      /organism="Homo sapiens"

<400> 65
Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                   15    
Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Asp 
            20                   25                  30        
Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro Asp 
        35                   40                  45            
Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val Gln 
    50                   55                  60                
Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala Arg 
65                   70                  75                  80
Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys Lys 
                85                   90                  95    
Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala Val 
            100                  105                110        
Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys His 
        115                  120                125            
Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser Ala 
    130                  135                140                
Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                  150                155                

<210> 66
<211> 161
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..161
<223> /mol_type="protein"
      /note="transforming growth factor alpha isoform 3 preproprotein"
      /organism="Homo sapiens"

<400> 66
Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                   15    
Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Asp 
            20                   25                  30        
Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro Asp 
        35                   40                  45            
Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val Gln 
    50                   55                  60                
Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala Arg 
65                   70                  75                  80
Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys Lys 
                85                   90                  95    
Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala Val 
            100                  105                110        
Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys His 
        115                  120                125            
Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser Ala 
    130                  135                140                
Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Ala Thr Leu 
145                  150                155                  160
Gly 
    

<210> 67
<211> 163
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..163
<223> /mol_type="protein"
      /note="transforming growth factor alpha isoform 4 preproprotein"
      /organism="Homo sapiens"

<400> 67
Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                   15    
Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala 
            20                   25                  30        
Asp Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro 
        35                   40                  45            
Asp Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val 
    50                   55                  60                
Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala 
65                   70                  75                  80
Arg Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys 
                85                   90                  95    
Lys Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala 
            100                  105                110        
Val Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys 
        115                  120                125            
His Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser 
    130                  135                140                
Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Gly Cys 
145                  150                155                  160
Arg Leu Tyr 
            

<210> 68
<211> 163
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..163
<223> /mol_type="protein"
      /note="transforming growth factor alpha isoform 5 preproprotein "
      /organism="Homo sapiens"

<400> 68
Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                   15    
Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala 
            20                   25                  30        
Asp Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro 
        35                   40                  45            
Asp Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val 
    50                   55                  60                
Gln Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala 
65                   70                  75                  80
Arg Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys 
                85                   90                  95    
Lys Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala 
            100                  105                110        
Val Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys 
        115                  120                125            
His Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser 
    130                  135                140                
Ala Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Gly Cys 
145                  150                155                  160
Arg Leu Tyr 
            

<210> 69
<211> 50
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..50
<223> /mol_type="protein"
      /note="mature transforming growth factor alpha"
      /organism="Homo sapiens"

<400> 69
Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                   15    
Phe His Gly Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys 
            20                   25                  30        
Val Cys His Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu 
        35                   40                  45            
Leu Ala 
    50

<210> 70
<211> 252
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..252
<223> /mol_type="protein"
      /note="amphiregulin preproprotein "
      /organism="Homo sapiens"

<400> 70
Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu 
1               5                   10                   15    
Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Thr 
            20                   25                  30        
Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly 
        35                   40                  45            
Phe Glu Val Thr Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser 
    50                   55                  60                
Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp 
65                   70                  75                  80
Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr 
                85                   90                  95    
Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln 
            100                  105                110        
Asn Lys Thr Glu Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys 
        115                  120                125            
Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn 
    130                  135                140                
Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys 
145                  150                155                  160
Tyr Ile Glu His Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr 
                165                  170                175    
Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Thr His Ser Met Ile 
            180                  185                190        
Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met 
        195                  200                205            
Ser Ala Val Ile Leu Thr Ala Val Ala Val Ile Thr Val Gln Leu Arg 
    210                  215                220                
Arg Gln Tyr Val Arg Lys Tyr Glu Gly Glu Ala Glu Glu Arg Lys Lys 
225                  230                235                  240
Leu Arg Gln Glu Asn Gly Asn Val His Ala Ile Ala 
                245                  250        

<210> 71
<211> 87
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..87
<223> /mol_type="protein"
      /note="mature amphiregulin "
      /organism="Homo sapiens"

<400> 71
Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln Asn Lys Thr Glu 
1               5                   10                   15    
Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys Lys Gly Gly Lys 
            20                   25                  30        
Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn Pro Cys Asn Ala 
        35                   40                  45            
Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys Tyr Ile Glu His 
    50                   55                  60                
Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr Phe Gly Glu Arg 
65                   70                  75                  80
Cys Gly Glu Lys Ser Met Lys 
                85        

<210> 72
<211> 169
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..169
<223> /mol_type="protein"
      /note="epiregulin preproprotein"
      /organism="Homo sapiens"

<400> 72
Met Thr Ala Gly Arg Arg Met Glu Met Leu Cys Ala Gly Arg Val Pro 
1               5                   10                   15    
Ala Leu Leu Leu Cys Leu Gly Phe His Leu Leu Gln Ala Val Leu Ser 
            20                   25                  30        
Thr Thr Val Ile Pro Ser Cys Ile Pro Gly Glu Ser Ser Asp Asn Cys 
        35                   40                  45            
Thr Ala Leu Val Gln Thr Glu Asp Asn Pro Arg Val Ala Gln Val Ser 
    50                   55                  60                
Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr Cys Leu His Gly Gln 
65                   70                  75                  80
Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr Cys Arg Cys Glu Val 
                85                   90                  95    
Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe Leu Thr Val His Gln 
            100                  105                110        
Pro Leu Ser Lys Glu Tyr Val Ala Leu Thr Val Ile Leu Ile Ile Leu 
        115                  120                125            
Phe Leu Ile Thr Val Val Gly Ser Thr Tyr Tyr Phe Cys Arg Trp Tyr 
    130                  135                140                
Arg Asn Arg Lys Ser Lys Glu Pro Lys Lys Glu Tyr Glu Arg Val Thr 
145                  150                155                  160
Ser Gly Asp Pro Glu Leu Pro Gln Val 
                165                

<210> 73
<211> 49
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..49
<223> /mol_type="protein"
      /note="mature epiregulin "
      /organism="Homo sapiens"

<400> 73
Val Ala Gln Val Ser Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr 
1               5                   10                   15    
Cys Leu His Gly Gln Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr 
            20                   25                  30        
Cys Arg Cys Glu Val Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe 
        35                   40                  45            
Leu 
    

<210> 74
<211> 154
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..154
<223> /mol_type="protein"
      /note="epigen isoform 1 precursor"
      /organism="Homo sapiens"

<400> 74
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                   15    
Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                   25                  30        
Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                   40                  45            
Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                   55                  60                
Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                   70                  75                  80
Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Glu 
                85                   90                  95    
His Leu Thr Leu Thr Ser Tyr Ala Val Asp Ser Tyr Glu Lys Tyr Ile 
            100                  105                110        
Ala Ile Gly Ile Gly Val Gly Leu Leu Leu Ser Gly Phe Leu Val Ile 
        115                  120                125            
Phe Tyr Cys Tyr Ile Arg Lys Arg Cys Leu Lys Leu Lys Ser Pro Tyr 
    130                  135                140                
Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
145                  150                

<210> 75
<211> 133
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..133
<223> /mol_type="protein"
      /note="epigen isoform 2 precursor"
      /organism="Homo sapiens"

<400> 75
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                   15    
Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                   25                  30        
Ala Gln Gln Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser 
        35                   40                  45            
His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys 
    50                   55                  60                
Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Phe Thr Gly 
65                   70                  75                  80
Tyr Thr Gly Glu Arg Cys Glu His Leu Thr Leu Thr Ser Tyr Ala Val 
                85                   90                  95    
Asp Ser Tyr Glu Lys Tyr Ile Ala Ile Gly Ile Gly Val Gly Leu Leu 
            100                  105                110        
Leu Ser Gly Phe Leu Val Ile Phe Tyr Cys Tyr Ile Arg Lys Arg Tyr 
        115                  120                125            
Glu Lys Asp Lys Ile 
    130            

<210> 76
<211> 112
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..112
<223> /mol_type="protein"
      /note="epigen isoform 3 precursor"
      /organism="Homo sapiens"

<400> 76
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                   15    
Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                   25                  30        
Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                   40                  45            
Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                   55                  60                
Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                   70                  75                  80
Lys Ala Ile Cys Arg Cys Phe Thr Gly Tyr Thr Gly Glu Arg Cys Leu 
                85                   90                  95    
Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
            100                  105                110        

<210> 77
<211> 103
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..103
<223> /mol_type="protein"
      /note="epigen isoform 4 precursor "
      /organism="Homo sapiens"

<400> 77
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                   15    
Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                   25                  30        
Ala Gln Gln Gly Asn Trp Thr Val Asn Lys Thr Glu Ala Asp Asn Ile 
        35                   40                  45            
Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu Asp His 
    50                   55                  60                
Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu Leu Glu 
65                   70                  75                  80
Lys Ala Ile Cys Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys 
                85                   90                  95    
Ser Gly Glu Arg Arg Pro Leu 
            100            

<210> 78
<211> 103
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..103
<223> /mol_type="protein"
      /note="epigen isoform 5 precursor "
      /organism="Homo sapiens"

<400> 78
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                   15    
Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                   25                  30        
Ala Gln Gln Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser 
        35                   40                  45            
His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys 
    50                   55                  60                
Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Phe Thr Gly 
65                   70                  75                  80
Tyr Thr Gly Glu Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys 
                85                   90                  95    
Ser Gly Glu Arg Arg Pro Leu 
            100            

<210> 79
<211> 94
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..94
<223> /mol_type="protein"
      /note="epigen isoform 6 precursor "
      /organism="Homo sapiens"

<400> 79
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                   15    
Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                   25                  30        
Ala Gln Gln Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser 
        35                   40                  45            
His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys 
    50                   55                  60                
Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Leu Lys Leu 
65                   70                  75                  80
Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu Arg Arg Pro Leu 
                85                   90                

<210> 80
<211> 73
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..73
<223> /mol_type="protein"
      /note="epigen isoform 7 precursor "
      /organism="Homo sapiens"

<400> 80
Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Asp 
1               5                   10                   15    
Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser His Leu Cys Leu Glu 
            20                   25                  30        
Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys Ala Phe His His Glu 
        35                   40                  45            
Leu Glu Lys Ala Ile Cys Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn 
    50                   55                  60                
Val Cys Ser Gly Glu Arg Arg Pro Leu 
65                   70            

<210> 81
<211> 132
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..132
<223> /mol_type="protein"
      /note="mature epigen "
      /organism="Homo sapiens"

<400> 81
Ala Ala Val Thr Val Thr Pro Pro Ile Thr Ala Gln Gln Gly Asn Trp 
1               5                   10                   15    
Thr Val Asn Lys Thr Glu Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu 
            20                   25                  30        
Lys Phe Ser His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn 
        35                   40                  45            
Gly Ala Cys Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys 
    50                   55                  60                
Phe Thr Gly Tyr Thr Gly Glu Arg Cys Glu His Leu Thr Leu Thr Ser 
65                   70                  75                  80
Tyr Ala Val Asp Ser Tyr Glu Lys Tyr Ile Ala Ile Gly Ile Gly Val 
                85                   90                  95    
Gly Leu Leu Leu Ser Gly Phe Leu Val Ile Phe Tyr Cys Tyr Ile Arg 
            100                  105                110        
Lys Arg Cys Leu Lys Leu Lys Ser Pro Tyr Asn Val Cys Ser Gly Glu 
        115                  120                125            
Arg Arg Pro Leu 
    130        

<210> 82
<211> 178
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..178
<223> /mol_type="protein"
      /note="betacellulin precursor "
      /organism="Homo sapiens"

<400> 82
Met Asp Arg Ala Ala Arg Cys Ser Gly Ala Ser Ser Leu Pro Leu Leu 
1               5                   10                   15    
Leu Ala Leu Ala Leu Gly Leu Val Ile Leu His Cys Val Val Ala Asp 
            20                   25                  30        
Gly Asn Ser Thr Arg Ser Pro Glu Thr Asn Gly Leu Leu Cys Gly Asp 
        35                   40                  45            
Pro Glu Glu Asn Cys Ala Ala Thr Thr Thr Gln Ser Lys Arg Lys Gly 
    50                   55                  60                
His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys Gly 
65                   70                  75                  80
Arg Cys Arg Phe Val Val Ala Glu Gln Thr Pro Ser Cys Val Cys Asp 
                85                   90                  95    
Glu Gly Tyr Ile Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr Leu 
            100                  105                110        
Arg Gly Asp Arg Gly Gln Ile Leu Val Ile Cys Leu Ile Ala Val Met 
        115                  120                125            
Val Val Phe Ile Ile Leu Val Ile Gly Val Cys Thr Cys Cys His Pro 
    130                  135                140                
Leu Arg Lys Arg Arg Lys Arg Lys Lys Lys Glu Glu Glu Met Glu Thr 
145                  150                155                  160
Leu Gly Lys Asp Ile Thr Pro Ile Asn Glu Asp Ile Glu Glu Thr Asn 
                165                  170                175    
Ile Ala 
        

<210> 83
<211> 80
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..80
<223> /mol_type="protein"
      /note="mature betacellulin "
      /organism="Homo sapiens"

<400> 83
Asp Gly Asn Ser Thr Arg Ser Pro Glu Thr Asn Gly Leu Leu Cys Gly 
1               5                   10                   15    
Asp Pro Glu Glu Asn Cys Ala Ala Thr Thr Thr Gln Ser Lys Arg Lys 
            20                   25                  30        
Gly His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys 
        35                   40                  45            
Gly Arg Cys Arg Phe Val Val Ala Glu Gln Thr Pro Ser Cys Val Cys 
    50                   55                  60                
Asp Glu Gly Tyr Ile Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr 
65                   70                  75                  80

