                         SEQUENCE LISTING

<110>  TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER 
       EDUCATION
       Yang, Xiaofeng
 
<120>  EARLY HYPERLIPIDEMIA PROMOTES ENDOTHELIAL ACTIVATION VIA A 
       CASPASE-1-SIRTUIN 1 PATHWAY

<130>  206017-0053-00-WO.605091

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  36
<212>  PRT
<213>  Mus musculus

<400>  1

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Tyr Arg Asp Asn Leu Leu Leu Thr Ala Gly Leu Leu Thr Asn Gly 
            20                  25                  30          


Phe His Ser Cys 
        35      


<210>  2
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


Gly Tyr Arg Asp Asn Leu Leu Phe Gly Ala Glu Ile Ile Thr Asn Gly 
            20                  25                  30          


Phe His Ser Cys 
        35      


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  3
gcctagccga gggagagccg                                                   20


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  4
tgtgacttgg gagctctgca gc                                                22


<210>  5
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  5
gccgccccga ctgcatct                                                     18


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  6
atggcacacc acagatatcg g                                                 21


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  7
tgctaaagcg catgctccag actg                                              24


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  8
gagacatata agggagaagg g                                                 21


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  9
aagtgactgc tccattcgga a                                                 21


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  10
ctccgagaac agctggtctt ct                                                22


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  11
tgaagaggag tggatgggtt                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  12
ttcaatgcac tggaatctgc                                                   20


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  13
atggacgcct tggacctcac cg                                                22


<210>  14
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  14
tggcttggct gccgactgag ga                                                22


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  15
agctcctcag gcagtgcagg a                                                 21


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  16
agagcaagac gtgtgcggct                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  17
acagatgaag tgctccttcc a                                                 21


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  18
gtcggagatt cgtagctgga t                                                 21


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  19
accttctaca atgagctgcg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  20
cctggatagc aagtacatgg                                                   20


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  21
ccctcaagtt ttgcccttta ga                                                22


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  22
ccctcggaga aagatgttga aa                                                22


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  23
gttctctaat gtctccgagg c                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  24
cttcagaggc aggaaacagg                                                   20


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  25
gcaaaggaca ctggaaaaga g                                                 21


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  26
tcaaagggat acacattagg gac                                               23


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  27
gctggagaac ttgcgtttaa g                                                 21


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  28
agataaggct tcacactgga c                                                 21


<210>  29
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  29
gaggccggtg ctgagtatgt cgtgga                                            26


<210>  30
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  30
cacacccatc acaaactggg ggcat                                             25


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  31
cgcttgatga ctcagccgga a                                                 21


<210>  32
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  32
agttgagggg actttcccag gc                                                22


<210>  33
<211>  736
<212>  PRT
<213>  Mus musculus

<400>  33

Met Ala Asp Glu Val Ala Leu Ala Leu Gln Ala Ala Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Ala Ala Met Glu Ala Ala Ser Gln Pro Ala Asp Glu Pro Leu 
            20                  25                  30          


Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Gly Arg Ser Pro Gly 
        35                  40                  45              


Glu Pro Ser Ala Ala Val Ala Pro Ala Ala Ala Gly Cys Glu Ala Ala 
    50                  55                  60                  


Ser Ala Ala Ala Pro Ala Ala Leu Trp Arg Glu Ala Ala Gly Ala Ala 
65                  70                  75                  80  


Ala Ser Ala Glu Arg Glu Ala Pro Ala Thr Ala Val Ala Gly Asp Gly 
                85                  90                  95      


Asp Asn Gly Ser Gly Leu Arg Arg Glu Pro Arg Ala Ala Asp Asp Phe 
            100                 105                 110         


Asp Asp Asp Glu Gly Glu Glu Glu Asp Glu Ala Ala Ala Ala Ala Ala 
        115                 120                 125             


Ala Ala Ala Ile Gly Tyr Arg Asp Asn Leu Leu Leu Thr Asp Gly Leu 
    130                 135                 140                 


Leu Thr Asn Gly Phe His Ser Cys Glu Ser Asp Asp Asp Asp Arg Thr 
145                 150                 155                 160 


Ser His Ala Ser Ser Ser Asp Trp Thr Pro Arg Pro Arg Ile Gly Pro 
                165                 170                 175     


Tyr Thr Phe Val Gln Gln His Leu Met Ile Gly Thr Asp Pro Arg Thr 
            180                 185                 190         


Ile Leu Lys Asp Leu Leu Pro Glu Thr Ile Pro Pro Pro Glu Leu Asp 
        195                 200                 205             


Asp Met Thr Leu Trp Gln Ile Val Ile Asn Ile Leu Ser Glu Pro Pro 
    210                 215                 220                 


Lys Arg Lys Lys Arg Lys Asp Ile Asn Thr Ile Glu Asp Ala Val Lys 
225                 230                 235                 240 


Leu Leu Gln Glu Cys Lys Lys Ile Ile Val Leu Thr Gly Ala Gly Val 
                245                 250                 255     


Ser Val Ser Cys Gly Ile Pro Asp Phe Arg Ser Arg Asp Gly Ile Tyr 
            260                 265                 270         


Ala Arg Leu Ala Val Asp Phe Pro Asp Leu Pro Asp Pro Gln Ala Met 
        275                 280                 285             


Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe Lys Phe 
    290                 295                 300                 


Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys His Lys 
305                 310                 315                 320 


Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn Tyr Thr 
                325                 330                 335     


Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg Ile Leu 
            340                 345                 350         


Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys Lys Tyr 
        355                 360                 365             


Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln Val Val 
    370                 375                 380                 


Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile Met Lys 
385                 390                 395                 400 


Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe His Arg 
                405                 410                 415     


Ala Met Lys Tyr Asp Lys Asp Glu Val Asp Leu Leu Ile Val Ile Gly 
            420                 425                 430         


Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser Ile Pro 
        435                 440                 445             


His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro His Leu 
    450                 455                 460                 


His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile Asn Glu 
465                 470                 475                 480 


Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys Asn Pro 
                485                 490                 495     


Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg Pro Gln Lys Glu 
            500                 505                 510         


Leu Val His Leu Ser Glu Leu Pro Pro Thr Pro Leu His Ile Ser Glu 
        515                 520                 525             


Asp Ser Ser Ser Pro Glu Arg Thr Val Pro Gln Asp Ser Ser Val Ile 
    530                 535                 540                 


Ala Thr Leu Val Asp Gln Ala Thr Asn Asn Asn Val Asn Asp Leu Glu 
545                 550                 555                 560 


Val Ser Glu Ser Ser Cys Val Glu Glu Lys Pro Gln Glu Val Gln Thr 
                565                 570                 575     


Ser Arg Asn Val Glu Asn Ile Asn Val Glu Asn Pro Asp Phe Lys Ala 
            580                 585                 590         


Val Gly Ser Ser Thr Ala Asp Lys Asn Glu Arg Thr Ser Val Ala Glu 
        595                 600                 605             


Thr Val Arg Lys Cys Trp Pro Asn Arg Leu Ala Lys Glu Gln Ile Ser 
    610                 615                 620                 


Lys Arg Leu Glu Gly Asn Gln Tyr Leu Phe Val Pro Pro Asn Arg Tyr 
625                 630                 635                 640 


Ile Phe His Gly Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu 
                645                 650                 655     


Ser Ser Ser Ser Cys Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser 
            660                 665                 670         


Pro Ser Leu Glu Glu Pro Leu Glu Asp Glu Ser Glu Ile Glu Glu Phe 
        675                 680                 685             


Tyr Asn Gly Leu Glu Asp Asp Thr Glu Arg Pro Glu Cys Ala Gly Gly 
    690                 695                 700                 


Ser Gly Phe Gly Ala Asp Gly Gly Asp Gln Glu Val Val Asn Glu Ala 
705                 710                 715                 720 


Ile Ala Thr Arg Gln Glu Leu Thr Asp Val Asn Tyr Pro Ser Asp Lys 
                725                 730                 735     


<210>  34
<211>  747
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Ala Gly Ala Asp Arg Glu Ala Ala Ser Ser Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Gly Pro Gly Leu Glu Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Ala 
    50                  55                  60                  


Arg Gly Cys Pro Gly Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Glu 
65                  70                  75                  80  


Ala Glu Ala Ala Ala Ala Gly Gly Glu Gln Glu Ala Gln Ala Thr Ala 
                85                  90                  95      


Ala Ala Gly Glu Gly Asp Asn Gly Pro Gly Leu Gln Gly Pro Ser Arg 
            100                 105                 110         


Glu Pro Pro Leu Ala Asp Asn Leu Tyr Asp Glu Asp Asp Asp Asp Glu 
        115                 120                 125             


Gly Glu Glu Glu Glu Glu Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp 
    130                 135                 140                 


Asn Leu Leu Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys 
145                 150                 155                 160 


Glu Ser Asp Glu Glu Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp 
                165                 170                 175     


Thr Pro Arg Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu 
            180                 185                 190         


Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
        195                 200                 205             


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
    210                 215                 220                 


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
225                 230                 235                 240 


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
                245                 250                 255     


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
            260                 265                 270         


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
        275                 280                 285             


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
    290                 295                 300                 


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
305                 310                 315                 320 


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
                325                 330                 335     


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
            340                 345                 350         


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
        355                 360                 365             


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
    370                 375                 380                 


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
385                 390                 395                 400 


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
                405                 410                 415     


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
            420                 425                 430         


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
        435                 440                 445             


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
    450                 455                 460                 


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
465                 470                 475                 480 


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
                485                 490                 495     


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
            500                 505                 510         


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 
        515                 520                 525             


Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
    530                 535                 540                 


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 
545                 550                 555                 560 


Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 
                565                 570                 575     


Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 
            580                 585                 590         


Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 
        595                 600                 605             


Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 
    610                 615                 620                 


Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 
625                 630                 635                 640 


Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 
                645                 650                 655     


Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 
            660                 665                 670         


Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 
        675                 680                 685             


Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 
    690                 695                 700                 


Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 
705                 710                 715                 720 


Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 
                725                 730                 735     


Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
            740                 745         


