                         SEQUENCE LISTING

<110>  President and Fellows of Harvard College
 
<120>  PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY

<130>  29297-127001WO

<140>  62/110,203
<141>  2015-01-30

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-Beta inhibitor


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Y is phosphotyrosine

<400>  1

Pro Tyr Leu Lys Thr Lys 
1               5       


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TGF-Beta inhibitor


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Y is phosphotyrosine

<400>  2

Tyr Leu Pro Gln Thr Val 
1               5       


<210>  3
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  4
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Val Leu Ala Pro Ala Trp Ser Pro Thr Thr Tyr Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Gly Leu Ser Gly Thr Gln Asp Cys Ser Phe 
            20                  25                  30          


Gln His Ser Pro Ile Ser Ser Asp Phe Ala Val Lys Ile Arg Glu Leu 
        35                  40                  45              


Ser Asp Tyr Leu Leu Gln Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 
    50                  55                  60                  


Gln Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gln 
65                  70                  75                  80  


Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gln Gly 
                85                  90                  95      


Leu Leu Glu Arg Val Asn Thr Glu Ile His Phe Val Thr Lys Cys Ala 
            100                 105                 110         


Phe Gln Pro Pro Pro Ser Cys Leu Arg Phe Val Gln Thr Asn Ile Ser 
        115                 120                 125             


Arg Leu Leu Gln Glu Thr Ser Glu Gln Leu Val Ala Leu Lys Pro Trp 
    130                 135                 140                 


Ile Thr Arg Gln Asn Phe Ser Arg Cys Leu Glu Leu Gln Cys Gln Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Glu Ala 
                165                 170                 175     


Thr Ala Pro Thr Ala Pro Gln Pro Pro Leu Leu Leu Leu Leu Leu Leu 
            180                 185                 190         


Pro Val Gly Leu Leu Leu Leu Ala Ala Ala Trp Cys Leu His Trp Gln 
        195                 200                 205             


Arg Thr Arg Arg Arg Thr Pro Arg Pro Gly Glu Gln Val Pro Pro Val 
    210                 215                 220                 


Pro Ser Pro Gln Asp Leu Leu Leu Val Glu His 
225                 230                 235 


<210>  5
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Asn Phe Asp Cys Cys 
            20                  25                  30          


Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly Phe 
        35                  40                  45              


Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile Phe 
    50                  55                  60                  


His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr Trp 
65                  70                  75                  80  


Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95  


<210>  6
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu 
1               5                   10                  15      


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser 
    130                 135 


<210>  7
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Leu Leu Ile Leu Ala Leu Leu Gly Ile Cys Ser Leu Thr Ala 
1               5                   10                  15      


Tyr Ile Val Glu Gly Val Gly Ser Glu Val Ser Asp Lys Arg Thr Cys 
            20                  25                  30          


Val Ser Leu Thr Thr Gln Arg Leu Pro Val Ser Arg Ile Lys Thr Tyr 
        35                  40                  45              


Thr Ile Thr Glu Gly Ser Leu Arg Ala Val Ile Phe Ile Thr Lys Arg 
    50                  55                  60                  


Gly Leu Lys Val Cys Ala Asp Pro Gln Ala Thr Trp Val Arg Asp Val 
65                  70                  75                  80  


Val Arg Ser Met Asp Arg Lys Ser Asn Thr Arg Asn Asn Met Ile Gln 
                85                  90                  95      


Thr Lys Pro Thr Gly Thr Gln Gln Ser Thr Asn Thr Ala Val Thr Leu 
            100                 105                 110         


Thr Gly 
        


<210>  8
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  9
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  10
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Cys Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Arg Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Val Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Arg Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Arg Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Asp Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Val Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  11
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  11

Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      


Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          


Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              


Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  


Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  


Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      


Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         


Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             


Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 


Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 


Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     


Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         


Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             


Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 


Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 


Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     


Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         


Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             


Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 


Cys Ser 
305     


<210>  12
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      


His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          


Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              


His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  


Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  


Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      


Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         


Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             


Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 


Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 


Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     


Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         


Tyr Leu Asn Ala Ser 
        195         


<210>  13
<211>  1448
<212>  DNA
<213>  Homo sapiens

<400>  13
gtgaccgagc ggcgcggacg gccgcctgcc ccctctgcca cctggggcgg tgcgggcccg       60

gagcccggag cccgggtagc gcgtagagcc ggcgcgatgc acgtgcgctc actgcgagct      120

gcggcgccgc acagcttcgt ggcgctctgg gcacccctgt tcctgctgcg ctccgccctg      180

gccgacttca gcctggacaa cgaggtgcac tcgagcttca tccaccggcg cctccgcagc      240

caggagcggc gggagatgca gcgcgagatc ctctccattt tgggcttgcc ccaccgcccg      300

cgcccgcacc tccagggcaa gcacaactcg gcacccatgt tcatgctgga cctgtacaac      360

gccatggcgg tggaggaggg cggcgggccc ggcggccagg gcttctccta cccctacaag      420

gccgtcttca gtacccaggg cccccctctg gccagcctgc aagatagcca tttcctcacc      480

gacgccgaca tggtcatgag cttcgtcaac ctcgtggaac atgacaagga attcttccac      540

ccacgctacc accatcgaga gttccggttt gatctttcca agatcccaga aggggaagct      600

gtcacggcag ccgaattccg gatctacaag gactacatcc gggaacgctt cgacaatgag      660

acgttccgga tcagcgttta tcaggtgctc caggagcact tgggcaggga atcggatctc      720

ttcctgctcg acagccgtac cctctgggcc tcggaggagg gctggctggt gtttgacatc      780

acagccacca gcaaccactg ggtggtcaat ccgcggcaca acctgggcct gcagctctcg      840

gtggagacgc tggatgggca gagcatcaac cccaagttgg cgggcctgat tgggcggcac      900

gggccccaga acaagcagcc cttcatggtg gctttcttca aggccacgga ggtccacttc      960

cgcagcatcc ggtccacggg gagcaaacag cgcagccaga accgctccaa gacgcccaag     1020

aaccaggaag ccctgcggat ggccaacgtg gcagagaaca gcagcagcga ccagaggcag     1080

gcctgtaaga agcacgagct gtatgtcagc ttccgagacc tgggctggca ggactggatc     1140

atcgcgcctg aaggctacgc cgcctactac tgtgaggggg agtgtgcctt ccctctgaac     1200

tcctacatga acgccaccaa ccacgccatc gtgcagacgc tggtccactt catcaacccg     1260

gaaacggtgc ccaagccctg ctgtgcgccc acgcagctca atgccatctc cgtcctctac     1320

ttcgatgaca gctccaacgt catcctgaag aaatacagaa acatggtggt ccgggcctgt     1380

ggctgccact agctcctccg agaattcaga ccctttgggg ccaagttttt ctggatcctc     1440

cattgctc                                                              1448


<210>  14
<211>  4978
<212>  DNA
<213>  Homo sapiens

<400>  14
ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag       60

ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc      120

ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg      180

cgcagccccg gcctctcggc ctctgccgga gaaacagttg ggacccctga ttttagcagg      240

atggcccaat ggaatcagct acagcagctt gacacacggt acctggagca gctccatcag      300

ctctacagtg acagcttccc aatggagctg cggcagtttc tggccccttg gattgagagt      360

caagattggg catatgcggc cagcaaagaa tcacatgcca ctttggtgtt tcataatctc      420

ctgggagaga ttgaccagca gtatagccgc ttcctgcaag agtcgaatgt tctctatcag      480

cacaatctac gaagaatcaa gcagtttctt cagagcaggt atcttgagaa gccaatggag      540

attgcccgga ttgtggcccg gtgcctgtgg gaagaatcac gccttctaca gactgcagcc      600

actgcggccc agcaaggggg ccaggccaac caccccacag cagccgtggt gacggagaag      660

cagcagatgc tggagcagca ccttcaggat gtccggaaga gagtgcagga tctagaacag      720

aaaatgaaag tggtagagaa tctccaggat gactttgatt tcaactataa aaccctcaag      780

agtcaaggag acatgcaaga tctgaatgga aacaaccagt cagtgaccag gcagaagatg      840

cagcagctgg aacagatgct cactgcgctg gaccagatgc ggagaagcat cgtgagtgag      900

ctggcggggc ttttgtcagc gatggagtac gtgcagaaaa ctctcacgga cgaggagctg      960

gctgactgga agaggcggca acagattgcc tgcattggag gcccgcccaa catctgccta     1020

gatcggctag aaaactggat aacgtcatta gcagaatctc aacttcagac ccgtcaacaa     1080

attaagaaac tggaggagtt gcagcaaaaa gtttcctaca aaggggaccc cattgtacag     1140

caccggccga tgctggagga gagaatcgtg gagctgttta gaaacttaat gaaaagtgcc     1200

tttgtggtgg agcggcagcc ctgcatgccc atgcatcctg accggcccct cgtcatcaag     1260

accggcgtcc agttcactac taaagtcagg ttgctggtca aattccctga gttgaattat     1320

cagcttaaaa ttaaagtgtg cattgacaaa gactctgggg acgttgcagc tctcagagga     1380

tcccggaaat ttaacattct gggcacaaac acaaaagtga tgaacatgga agaatccaac     1440

aacggcagcc tctctgcaga attcaaacac ttgaccctga gggagcagag atgtgggaat     1500

gggggccgag ccaattgtga tgcttccctg attgtgactg aggagctgca cctgatcacc     1560

tttgagaccg aggtgtatca ccaaggcctc aagattgacc tagagaccca ctccttgcca     1620

gttgtggtga tctccaacat ctgtcagatg ccaaatgcct gggcgtccat cctgtggtac     1680

aacatgctga ccaacaatcc caagaatgta aactttttta ccaagccccc aattggaacc     1740

tgggatcaag tggccgaggt cctgagctgg cagttctcct ccaccaccaa gcgaggactg     1800

agcatcgagc agctgactac actggcagag aaactcttgg gacctggtgt gaattattca     1860

gggtgtcaga tcacatgggc taaattttgc aaagaaaaca tggctggcaa gggcttctcc     1920

ttctgggtct ggctggacaa tatcattgac cttgtgaaaa agtacatcct ggccctttgg     1980

aacgaagggt acatcatggg ctttatcagt aaggagcggg agcgggccat cttgagcact     2040

aagcctccag gcaccttcct gctaagattc agtgaaagca gcaaagaagg aggcgtcact     2100

ttcacttggg tggagaagga catcagcggt aagacccaga tccagtccgt ggaaccatac     2160

acaaagcagc agctgaacaa catgtcattt gctgaaatca tcatgggcta taagatcatg     2220

gatgctacca atatcctggt gtctccactg gtctatctct atcctgacat tcccaaggag     2280

gaggcattcg gaaagtattg tcggccagag agccaggagc atcctgaagc tgacccaggt     2340

agcgctgccc catacctgaa gaccaagttt atctgtgtga caccaacgac ctgcagcaat     2400

accattgacc tgccgatgtc cccccgcact ttagattcat tgatgcagtt tggaaataat     2460

ggtgaaggtg ctgaaccctc agcaggaggg cagtttgagt ccctcacctt tgacatggag     2520

ttgacctcgg agtgcgctac ctcccccatg tgaggagctg agaacggaag ctgcagaaag     2580

atacgactga ggcgcctacc tgcattctgc cacccctcac acagccaaac cccagatcat     2640

ctgaaactac taactttgtg gttccagatt ttttttaatc tcctacttct gctatctttg     2700

agcaatctgg gcacttttaa aaatagagaa atgagtgaat gtgggtgatc tgcttttatc     2760

taaatgcaaa taaggatgtg ttctctgaga cccatgatca ggggatgtgg cggggggtgg     2820

ctagagggag aaaaaggaaa tgtcttgtgt tgttttgttc ccctgccctc ctttctcagc     2880

agctttttgt tattgttgtt gttgttctta gacaagtgcc tcctggtgcc tgcggcatcc     2940

ttctgcctgt ttctgtaagc aaatgccaca ggccacctat agctacatac tcctggcatt     3000

gcacttttta accttgctga catccaaata gaagatagga ctatctaagc cctaggtttc     3060

tttttaaatt aagaaataat aacaattaaa gggcaaaaaa cactgtatca gcatagcctt     3120

tctgtattta agaaacttaa gcagccgggc atggtggctc acgcctgtaa tcccagcact     3180

ttgggaggcc gaggcggatc ataaggtcag gagatcaaga ccatcctggc taacacggtg     3240

aaaccccgtc tctactaaaa gtacaaaaaa ttagctgggt gtggtggtgg gcgcctgtag     3300

tcccagctac tcgggaggct gaggcaggag aatcgcttga acctgagagg cggaggttgc     3360

agtgagccaa aattgcacca ctgcacactg cactccatcc tgggcgacag tctgagactc     3420

tgtctcaaaa aaaaaaaaaa aaaaaagaaa cttcagttaa cagcctcctt ggtgctttaa     3480

gcattcagct tccttcaggc tggtaattta tataatccct gaaacgggct tcaggtcaaa     3540

cccttaagac atctgaagct gcaacctggc ctttggtgtt gaaataggaa ggtttaagga     3600

gaatctaagc attttagact tttttttata aatagactta ttttcctttg taatgtattg     3660

gccttttagt gagtaaggct gggcagaggg tgcttacaac cttgactccc tttctccctg     3720

gacttgatct gctgtttcag aggctaggtt gtttctgtgg gtgccttatc agggctggga     3780

tacttctgat tctggcttcc ttcctgcccc accctcccga ccccagtccc cctgatcctg     3840

ctagaggcat gtctccttgc gtgtctaaag gtccctcatc ctgtttgttt taggaatcct     3900

ggtctcagga cctcatggaa gaagaggggg agagagttac aggttggaca tgatgcacac     3960

tatggggccc cagcgacgtg tctggttgag ctcagggaat atggttctta gccagtttct     4020

tggtgatatc cagtggcact tgtaatggcg tcttcattca gttcatgcag ggcaaaggct     4080

tactgataaa cttgagtctg ccctcgtatg agggtgtata cctggcctcc ctctgaggct     4140

ggtgactcct ccctgctggg gccccacagg tgaggcagaa cagctagagg gcctccccgc     4200

ctgcccgcct tggctggcta gctcgcctct cctgtgcgta tgggaacacc tagcacgtgc     4260

tggatgggct gcctctgact cagaggcatg gccggatttg gcaactcaaa accaccttgc     4320

ctcagctgat cagagtttct gtggaattct gtttgttaaa tcaaattagc tggtctctga     4380

attaaggggg agacgacctt ctctaagatg aacagggttc gccccagtcc tcctgcctgg     4440

agacagttga tgtgtcatgc agagctctta cttctccagc aacactcttc agtacataat     4500

aagcttaact gataaacaga atatttagaa aggtgagact tgggcttacc attgggttta     4560

aatcataggg acctagggcg agggttcagg gcttctctgg agcagatatt gtcaagttca     4620

tggccttagg tagcatgtat ctggtcttaa ctctgattgt agcaaaagtt ctgagaggag     4680

ctgagccctg ttgtggccca ttaaagaaca gggtcctcag gccctgcccg cttcctgtcc     4740

actgccccct ccccatcccc agcccagccg agggaatccc gtgggttgct tacctaccta     4800

taaggtggtt tataagctgc tgtcctggcc actgcattca aattccaatg tgtacttcat     4860

agtgtaaaaa tttatattat tgtgaggttt tttgtctttt tttttttttt ttttttttgg     4920

tatattgctg tatctacttt aacttccaga aataaacgtt atataggaac cgtaaaaa       4978


<210>  15
<211>  1944
<212>  DNA
<213>  Homo sapiens

<400>  15
aatttctcac tgcccctgtg ataaactgtg gtcactggct gtggcagcaa ctattataag       60

atgctctgaa aactcttcag acactgaggg gcaccagagg agcagactac aagaatggca      120

cacgctatgg aaaactcctg gacaatcagt aaagagtacc atattgatga agaagtgggc      180

tttgctctgc caaatccaca ggaaaatcta cctgattttt ataatgactg gatgttcatt      240

gctaaacatc tgcctgatct catagagtct ggccagcttc gagaaagagt tgagaagtta      300

aacatgctca gcattgatca tctcacagac cacaagtcac agcgccttgc acgtctagtt      360

ctgggatgca tcaccatggc atatgtgtgg ggcaaaggtc atggagatgt ccgtaaggtc      420

ttgccaagaa atattgctgt tccttactgc caactctcca agaaactgga actgcctcct      480

attttggttt atgcagactg tgtcttggca aactggaaga aaaaggatcc taataagccc      540

ctgacttatg agaacatgga cgttttgttc tcatttcgtg atggagactg cagtaaagga      600

ttcttcctgg tctctctatt ggtggaaata gcagctgctt ctgcaatcaa agtaattcct      660

actgtattca aggcaatgca aatgcaagaa cgggacactt tgctaaaggc gctgttggaa      720

atagcttctt gcttggagaa agcccttcaa gtgtttcacc aaatccacga tcatgtgaac      780

ccaaaagcat ttttcagtgt tcttcgcata tatttgtctg gctggaaagg caacccccag      840

ctatcagacg gtctggtgta tgaagggttc tgggaagacc caaaggagtt tgcagggggc      900

agtgcaggcc aaagcagcgt ctttcagtgc tttgacgtcc tgctgggcat ccagcagact      960

gctggtggag gacatgctgc tcagttcctc caggacatga gaagatatat gccaccagct     1020

cacaggaact tcctgtgctc attagagtca aatccctcag tccgtgagtt tgtcctttca     1080

aaaggtgatg ctggcctgcg ggaagcttat gacgcctgtg tgaaagctct ggtctccctg     1140

aggagctacc atctgcaaat cgtgactaag tacatcctga ttcctgcaag ccagcagcca     1200

aaggagaata agacctctga agacccttca aaactggaag ccaaaggaac tggaggcact     1260

gatttaatga atttcctgaa gactgtaaga agtacaactg agaaatccct tttgaaggaa     1320

ggttaatgta acccaacaag agcacatttt atcatagcag agacatctgt atgcattcct     1380

gtcattaccc attgtaacag agccacaaac taatactatg caatgtttta ccaataatgc     1440

aatacaaaag acctcaaaat acctgtgcat ttcttgtagg aaaacaacaa aaggtaatta     1500

tgtgtaatta tactagaagt tttgtaatct gtatcttatc attggaataa aatgacattc     1560

aataaataaa aatgcataag atatattctg tcggctgggc gcggtggctc acgcctgtaa     1620

tcccagcact ttgggaggcc gaggcgggcg gatcacaagg tcaggagatc gagaccatct     1680

tggctaacac ggtgaaaccc cgtctctact aaaaatacaa aaaattagcc gggcgcggtg     1740

gcgggcacct gtagtcccag ctactcggga ggctgaggca ggagaatggc gtgaacctgg     1800

gaggcggagc ttgcagtgag ccaagattgt gccactgcaa tccggcctgg gctaaagagc     1860

gggactccgt ctcaaaaaaa aaaaaaaaaa gatatattct gtcataataa ataaaaatgc     1920

ataagatata aaaaaaaaaa aaaa                                            1944


<210>  16
<211>  2115
<212>  DNA
<213>  Homo sapiens

<400>  16
agtttccctt ccgctcacct ccgcctgagc agtggagaag gcggcactct ggtggggctg       60

ctccaggcat gcagatccca caggcgccct ggccagtcgt ctgggcggtg ctacaactgg      120

gctggcggcc aggatggttc ttagactccc cagacaggcc ctggaacccc cccaccttct      180

ccccagccct gctcgtggtg accgaagggg acaacgccac cttcacctgc agcttctcca      240

acacatcgga gagcttcgtg ctaaactggt accgcatgag ccccagcaac cagacggaca      300

agctggccgc cttccccgag gaccgcagcc agcccggcca ggactgccgc ttccgtgtca      360

cacaactgcc caacgggcgt gacttccaca tgagcgtggt cagggcccgg cgcaatgaca      420

gcggcaccta cctctgtggg gccatctccc tggcccccaa ggcgcagatc aaagagagcc      480

tgcgggcaga gctcagggtg acagagagaa gggcagaagt gcccacagcc caccccagcc      540

cctcacccag gccagccggc cagttccaaa ccctggtggt tggtgtcgtg ggcggcctgc      600

tgggcagcct ggtgctgcta gtctgggtcc tggccgtcat ctgctcccgg gccgcacgag      660

ggacaatagg agccaggcgc accggccagc ccctgaagga ggacccctca gccgtgcctg      720

tgttctctgt ggactatggg gagctggatt tccagtggcg agagaagacc ccggagcccc      780

ccgtgccctg tgtccctgag cagacggagt atgccaccat tgtctttcct agcggaatgg      840

gcacctcatc ccccgcccgc aggggctcag ctgacggccc tcggagtgcc cagccactga      900

ggcctgagga tggacactgc tcttggcccc tctgaccggc ttccttggcc accagtgttc      960

tgcagaccct ccaccatgag cccgggtcag cgcatttcct caggagaagc aggcagggtg     1020

caggccattg caggccgtcc aggggctgag ctgcctgggg gcgaccgggg ctccagcctg     1080

cacctgcacc aggcacagcc ccaccacagg actcatgtct caatgcccac agtgagccca     1140

ggcagcaggt gtcaccgtcc cctacaggga gggccagatg cagtcactgc ttcaggtcct     1200

gccagcacag agctgcctgc gtccagctcc ctgaatctct gctgctgctg ctgctgctgc     1260

tgctgctgcc tgcggcccgg ggctgaaggc gccgtggccc tgcctgacgc cccggagcct     1320

cctgcctgaa cttgggggct ggttggagat ggccttggag cagccaaggt gcccctggca     1380

gtggcatccc gaaacgccct ggacgcaggg cccaagactg ggcacaggag tgggaggtac     1440

atggggctgg ggactcccca ggagttatct gctccctgca ggcctagaga agtttcaggg     1500

aaggtcagaa gagctcctgg ctgtggtggg cagggcagga aacccctcca cctttacaca     1560

tgcccaggca gcacctcagg ccctttgtgg ggcagggaag ctgaggcagt aagcgggcag     1620

gcagagctgg aggcctttca ggcccagcca gcactctggc ctcctgccgc cgcattccac     1680

cccagcccct cacaccactc gggagaggga catcctacgg tcccaaggtc aggagggcag     1740

ggctggggtt gactcaggcc cctcccagct gtggccacct gggtgttggg agggcagaag     1800

tgcaggcacc tagggccccc catgtgccca ccctgggagc tctccttgga acccattcct     1860

gaaattattt aaaggggttg gccgggctcc caccagggcc tgggtgggaa ggtacaggcg     1920

ttcccccggg gcctagtacc cccgccgtgg cctatccact cctcacatcc acacactgca     1980

cccccactcc tggggcaggg ccaccagcat ccaggcggcc agcaggcacc tgagtggctg     2040

ggacaaggga tcccccttcc ctgtggttct attatattat aattataatt aaatatgaga     2100

gcatgctaag gaaaa                                                      2115


<210>  17
<211>  3691
<212>  DNA
<213>  Homo sapiens

<400>  17
ggcgcaacgc tgagcagctg gcgcgtcccg cgcggcccca gttctgcgca gcttcccgag       60

gctccgcacc agccgcgctt ctgtccgcct gcagggcatt ccagaaagat gaggatattt      120

gctgtcttta tattcatgac ctactggcat ttgctgaacg catttactgt cacggttccc      180

aaggacctat atgtggtaga gtatggtagc aatatgacaa ttgaatgcaa attcccagta      240

gaaaaacaat tagacctggc tgcactaatt gtctattggg aaatggagga taagaacatt      300

attcaatttg tgcatggaga ggaagacctg aaggttcagc atagtagcta cagacagagg      360

gcccggctgt tgaaggacca gctctccctg ggaaatgctg cacttcagat cacagatgtg      420

aaattgcagg atgcaggggt gtaccgctgc atgatcagct atggtggtgc cgactacaag      480

cgaattactg tgaaagtcaa tgccccatac aacaaaatca accaaagaat tttggttgtg      540

gatccagtca cctctgaaca tgaactgaca tgtcaggctg agggctaccc caaggccgaa      600

gtcatctgga caagcagtga ccatcaagtc ctgagtggta agaccaccac caccaattcc      660

aagagagagg agaagctttt caatgtgacc agcacactga gaatcaacac aacaactaat      720

gagattttct actgcacttt taggagatta gatcctgagg aaaaccatac agctgaattg      780

gtcatcccag aactacctct ggcacatcct ccaaatgaaa ggactcactt ggtaattctg      840

ggagccatct tattatgcct tggtgtagca ctgacattca tcttccgttt aagaaaaggg      900

agaatgatgg atgtgaaaaa atgtggcatc caagatacaa actcaaagaa gcaaagtgat      960

acacatttgg aggagacgta atccagcatt ggaacttctg atcttcaagc agggattctc     1020

aacctgtggt ttaggggttc atcggggctg agcgtgacaa gaggaaggaa tgggcccgtg     1080

ggatgcaggc aatgtgggac ttaaaaggcc caagcactga aaatggaacc tggcgaaagc     1140

agaggaggag aatgaagaaa gatggagtca aacagggagc ctggagggag accttgatac     1200

tttcaaatgc ctgaggggct catcgacgcc tgtgacaggg agaaaggata cttctgaaca     1260

aggagcctcc aagcaaatca tccattgctc atcctaggaa gacgggttga gaatccctaa     1320

tttgagggtc agttcctgca gaagtgccct ttgcctccac tcaatgcctc aatttgtttt     1380

ctgcatgact gagagtctca gtgttggaac gggacagtat ttatgtatga gtttttccta     1440

tttattttga gtctgtgagg tcttcttgtc atgtgagtgt ggttgtgaat gatttctttt     1500

gaagatatat tgtagtagat gttacaattt tgtcgccaaa ctaaacttgc tgcttaatga     1560

tttgctcaca tctagtaaaa catggagtat ttgtaaggtg cttggtctcc tctataacta     1620

caagtataca ttggaagcat aaagatcaaa ccgttggttg cataggatgt cacctttatt     1680

taacccatta atactctggt tgacctaatc ttattctcag acctcaagtg tctgtgcagt     1740

atctgttcca tttaaatatc agctttacaa ttatgtggta gcctacacac ataatctcat     1800

ttcatcgctg taaccaccct gttgtgataa ccactattat tttacccatc gtacagctga     1860

ggaagcaaac agattaagta acttgcccaa accagtaaat agcagacctc agactgccac     1920

ccactgtcct tttataatac aatttacagc tatattttac tttaagcaat tcttttattc     1980

aaaaaccatt tattaagtgc ccttgcaata tcaatcgctg tgccaggcat tgaatctaca     2040

gatgtgagca agacaaagta cctgtcctca aggagctcat agtataatga ggagattaac     2100

aagaaaatgt attattacaa tttagtccag tgtcatagca taaggatgat gcgaggggaa     2160

aacccgagca gtgttgccaa gaggaggaaa taggccaatg tggtctggga cggttggata     2220

tacttaaaca tcttaataat cagagtaatt ttcatttaca aagagaggtc ggtacttaaa     2280

ataaccctga aaaataacac tggaattcct tttctagcat tatatttatt cctgatttgc     2340

ctttgccata taatctaatg cttgtttata tagtgtctgg tattgtttaa cagttctgtc     2400

ttttctattt aaatgccact aaattttaaa ttcatacctt tccatgattc aaaattcaaa     2460

agatcccatg ggagatggtt ggaaaatctc cacttcatcc tccaagccat tcaagtttcc     2520

tttccagaag caactgctac tgcctttcat tcatatgttc ttctaaagat agtctacatt     2580

tggaaatgta tgttaaaagc acgtattttt aaaatttttt tcctaaatag taacacattg     2640

tatgtctgct gtgtactttg ctatttttat ttattttagt gtttcttata tagcagatgg     2700

aatgaatttg aagttcccag ggctgaggat ccatgccttc tttgtttcta agttatcttt     2760

cccatagctt ttcattatct ttcatatgat ccagtatatg ttaaatatgt cctacatata     2820

catttagaca accaccattt gttaagtatt tgctctagga cagagtttgg atttgtttat     2880

gtttgctcaa aaggagaccc atgggctctc cagggtgcac tgagtcaatc tagtcctaaa     2940

aagcaatctt attattaact ctgtatgaca gaatcatgtc tggaactttt gttttctgct     3000

ttctgtcaag tataaacttc actttgatgc tgtacttgca aaatcacatt ttctttctgg     3060

aaattccggc agtgtacctt gactgctagc taccctgtgc cagaaaagcc tcattcgttg     3120

tgcttgaacc cttgaatgcc accagctgtc atcactacac agccctccta agaggcttcc     3180

tggaggtttc gagattcaga tgccctggga gatcccagag tttcctttcc ctcttggcca     3240

tattctggtg tcaatgacaa ggagtacctt ggctttgcca catgtcaagg ctgaagaaac     3300

agtgtctcca acagagctcc ttgtgttatc tgtttgtaca tgtgcatttg tacagtaatt     3360

ggtgtgacag tgttctttgt gtgaattaca ggcaagaatt gtggctgagc aaggcacata     3420

gtctactcag tctattccta agtcctaact cctccttgtg gtgttggatt tgtaaggcac     3480

tttatccctt ttgtctcatg tttcatcgta aatggcatag gcagagatga tacctaattc     3540

tgcatttgat tgtcactttt tgtacctgca ttaatttaat aaaatattct tatttatttt     3600

gttacttggt acaccagcat gtccattttc ttgtttattt tgtgtttaat aaaatgttca     3660

gtttaacatc ccagtggaga aagttaaaaa a                                    3691


<210>  18
<211>  1923
<212>  DNA
<213>  Homo sapiens

<400>  18
cttctgtgtg tgcacatgtg taatacatat ctgggatcaa agctatctat ataaagtcct       60

tgattctgtg tgggttcaaa cacatttcaa agcttcagga tcctgaaagg ttttgctcta      120

cttcctgaag acctgaacac cgctcccata aagccatggc ttgccttgga tttcagcggc      180

acaaggctca gctgaacctg gctaccagga cctggccctg cactctcctg ttttttcttc      240

tcttcatccc tgtcttctgc aaagcaatgc acgtggccca gcctgctgtg gtactggcca      300

gcagccgagg catcgccagc tttgtgtgtg agtatgcatc tccaggcaaa gccactgagg      360

tccgggtgac agtgcttcgg caggctgaca gccaggtgac tgaagtctgt gcggcaacct      420

acatgatggg gaatgagttg accttcctag atgattccat ctgcacgggc acctccagtg      480

gaaatcaagt gaacctcact atccaaggac tgagggccat ggacacggga ctctacatct      540

gcaaggtgga gctcatgtac ccaccgccat actacctggg cataggcaac ggaacccaga      600

tttatgtaat tgctaaagaa aagaagccct cttacaacag gggtctatgt gaaaatgccc      660

ccaacagagc cagaatgtga aaagcaattt cagccttatt ttattcccat caattgagaa      720

accattatga agaagagagt ccatatttca atttccaaga gctgaggcaa ttctaacttt      780

tttgctatcc agctattttt atttgtttgt gcatttgggg ggaattcatc tctctttaat      840

ataaagttgg atgcggaacc caaattacgt gtactacaat ttaaagcaaa ggagtagaaa      900

gacagagctg ggatgtttct gtcacatcag ctccactttc agtgaaagca tcacttggga      960

ttaatatggg gatgcagcat tatgatgtgg gtcaaggaat taagttaggg aatggcacag     1020

cccaaagaag gaaaaggcag ggagcgaggg agaagactat attgtacaca ccttatattt     1080

acgtatgaga cgtttatagc cgaaatgatc ttttcaagtt aaattttatg ccttttattt     1140

cttaaacaaa tgtatgatta catcaaggct tcaaaaatac tcacatggct atgttttagc     1200

cagtgatgct aaaggttgta ttgcatatat acatatatat atatatatat atatatatat     1260

atatatatat atatatatat atatatattt taatttgata gtattgtgca tagagccacg     1320

tatgtttttg tgtatttgtt aatggtttga atataaacac tatatggcag tgtctttcca     1380

ccttgggtcc cagggaagtt ttgtggagga gctcaggaca ctaatacacc aggtagaaca     1440

caaggtcatt tgctaactag cttggaaact ggatgaggtc atagcagtgc ttgattgcgt     1500

ggaattgtgc tgagttggtg ttgacatgtg ctttggggct tttacaccag ttcctttcaa     1560

tggtttgcaa ggaagccaca gctggtggta tctgagttga cttgacagaa cactgtcttg     1620

aagacaatgg cttactccag gagacccaca ggtatgacct tctaggaagc tccagttcga     1680

tgggcccaat tcttacaaac atgtggttaa tgccatggac agaagaaggc agcaggtggc     1740

agaatggggt gcatgaaggt ttctgaaaat taacactgct tgtgttttta actcaatatt     1800

ttccatgaaa atgcaacaac atgtataata tttttaatta aataaaaatc tgtggtggtc     1860

gttttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaa                                                                   1923


<210>  19
<211>  1872
<212>  DNA
<213>  Homo sapiens

<400>  19
tcaggctgcc tgatctgccc agctttccag ctttcctctg gattccggcc tctggtcatc       60

cctccccacc ctctctccaa ggccctctcc tggtctccct tcttctagaa ccccttcctc      120

cacctccctc tctgcagaac ttctccttta ccccccaccc cccaccactg ccccctttcc      180

ttttctgacc tccttttgga gggctcagcg ctgcccagac cataggagag atgtgggagg      240

ctcagttcct gggcttgctg tttctgcagc cgctttgggt ggctccagtg aagcctctcc      300

agccaggggc tgaggtcccg gtggtgtggg cccaggaggg ggctcctgcc cagctcccct      360

gcagccccac aatccccctc caggatctca gccttctgcg aagagcaggg gtcacttggc      420

agcatcagcc agacagtggc ccgcccgctg ccgcccccgg ccatcccctg gcccccggcc      480

ctcacccggc ggcgccctcc tcctgggggc ccaggccccg ccgctacacg gtgctgagcg      540

tgggtcccgg aggcctgcgc agcgggaggc tgcccctgca gccccgcgtc cagctggatg      600

agcgcggccg gcagcgcggg gacttctcgc tatggctgcg cccagcccgg cgcgcggacg      660

ccggcgagta ccgcgccgcg gtgcacctca gggaccgcgc cctctcctgc cgcctccgtc      720

tgcgcctggg ccaggcctcg atgactgcca gccccccagg atctctcaga gcctccgact      780

gggtcatttt gaactgctcc ttcagccgcc ctgaccgccc agcctctgtg cattggttcc      840

ggaaccgggg ccagggccga gtccctgtcc gggagtcccc ccatcaccac ttagcggaaa      900

gcttcctctt cctgccccaa gtcagcccca tggactctgg gccctggggc tgcatcctca      960

cctacagaga tggcttcaac gtctccatca tgtataacct cactgttctg ggtctggagc     1020

ccccaactcc cttgacagtg tacgctggag caggttccag ggtggggctg ccctgccgcc     1080

tgcctgctgg tgtggggacc cggtctttcc tcactgccaa gtggactcct cctgggggag     1140

gccctgacct cctggtgact ggagacaatg gcgactttac ccttcgacta gaggatgtga     1200

gccaggccca ggctgggacc tacacctgcc atatccatct gcaggaacag cagctcaatg     1260

ccactgtcac attggcaatc atcacagtga ctcccaaatc ctttgggtca cctggatccc     1320

tggggaagct gctttgtgag gtgactccag tatctggaca agaacgcttt gtgtggagct     1380

ctctggacac cccatcccag aggagtttct caggaccttg gctggaggca caggaggccc     1440

agctcctttc ccagccttgg caatgccagc tgtaccaggg ggagaggctt cttggagcag     1500

cagtgtactt cacagagctg tctagcccag gtgcccaacg ctctgggaga gccccaggtg     1560

ccctcccagc aggccacctc ctgctgtttc tcacccttgg tgtcctttct ctgctccttt     1620

tggtgactgg agcctttggc tttcaccttt ggagaagaca gtggcgacca agacgatttt     1680

ctgccttaga gcaagggatt caccctccgc aggctcagag caagatagag gagctggagc     1740

aagaaccgga gccggagccg gagccggaac cggagcccga gcccgagccc gagccggagc     1800

agctctgacc tggagctgag gcagccagca gatctcagca gcccagtcca aataaacgtc     1860

ctgtctagca gc                                                         1872


<210>  20
<211>  1116
<212>  DNA
<213>  Homo sapiens

<400>  20
ggagagttaa aactgtgcct aacagaggtg tcctctgact tttcttctgc aagctccatg       60

ttttcacatc ttccctttga ctgtgtcctg ctgctgctgc tgctactact tacaaggtcc      120

tcagaagtgg aatacagagc ggaggtcggt cagaatgcct atctgccctg cttctacacc      180

ccagccgccc cagggaacct cgtgcccgtc tgctggggca aaggagcctg tcctgtgttt      240

gaatgtggca acgtggtgct caggactgat gaaagggatg tgaattattg gacatccaga      300

tactggctaa atggggattt ccgcaaagga gatgtgtccc tgaccataga gaatgtgact      360

ctagcagaca gtgggatcta ctgctgccgg atccaaatcc caggcataat gaatgatgaa      420

aaatttaacc tgaagttggt catcaaacca gccaaggtca cccctgcacc gactctgcag      480

agagacttca ctgcagcctt tccaaggatg cttaccacca ggggacatgg cccagcagag      540

acacagacac tggggagcct ccctgatata aatctaacac aaatatccac attggccaat      600

gagttacggg actctagatt ggccaatgac ttacgggact ctggagcaac catcagaata      660

ggcatctaca tcggagcagg gatctgtgct gggctggctc tggctcttat cttcggcgct      720

ttaattttca aatggtattc tcatagcaaa gagaagatac agaatttaag cctcatctct      780

ttggccaacc tccctccctc aggattggca aatgcagtag cagagggaat tcgctcagaa      840

gaaaacatct ataccattga agagaacgta tatgaagtgg aggagcccaa tgagtattat      900

tgctatgtca gcagcaggca gcaaccctca caacctttgg gttgtcgctt tgcaatgcca      960

tagatccaac caccttattt ttgagcttgg tgttttgtct ttttcagaaa ctatgagctg     1020

tgtcacctga ctggttttgg aggttctgtc cactgctatg gagcagagtt ttcccatttt     1080

cagaagataa tgactcacat gggaattgaa ctggga                               1116


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 1585

<400>  21
ggggtcaacg ttgagggggg                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 1668

<400>  22
tccatgacgt tcctgatgct                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 1826

<400>  23
tccatgacgt tcctgacgtt                                                   20


<210>  24
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2006

<400>  24
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  25
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2006-G5

<400>  25
tcgtcgtttt gtcgttttgt cgttggggg                                         29


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2216

<400>  26
gggggacgat cgtcgggggg                                                   20


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2336

<400>  27
ggggacgacg tcgtgggggg g                                                 21


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN 2395

<400>  28
tcgtcgtttt cggcgcgcgc cg                                                22


<210>  29
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ODN M362

<400>  29
tcgtcgtcgt tcgaacgacg ttgat                                             25


<210>  30
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
1               5                   10                  15      


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
            20                  25                  30          


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
        35                  40                  45              


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
    50                  55                  60                  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
65                  70                  75                  80  


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
                85                  90                  95      


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
            100                 105                 110         


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125             


<210>  31
<211>  125
<212>  PRT
<213>  Mus musculus

<400>  31

Met Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
1               5                   10                  15      


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
            20                  25                  30          


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
        35                  40                  45              


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
    50                  55                  60                  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
65                  70                  75                  80  


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
                85                  90                  95      


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
            100                 105                 110         


Thr Asp Ile Pro Phe Glu Cys Lys Lys Pro Val Gln Lys 
        115                 120                 125 


<210>  32
<211>  781
<212>  DNA
<213>  Homo sapiens

<400>  32
acacagagag aaaggctaaa gttctctgga ggatgtggct gcagagcctg ctgctcttgg       60

gcactgtggc ctgcagcatc tctgcacccg cccgctcgcc cagccccagc acgcagccct      120

gggagcatgt gaatgccatc caggaggccc ggcgtctcct gaacctgagt agagacactg      180

ctgctgagat gaatgaaaca gtagaagtca tctcagaaat gtttgacctc caggagccga      240

cctgcctaca gacccgcctg gagctgtaca agcagggcct gcggggcagc ctcaccaagc      300

tcaagggccc cttgaccatg atggccagcc actacaagca gcactgccct ccaaccccgg      360

aaacttcctg tgcaacccag attatcacct ttgaaagttt caaagagaac ctgaaggact      420

ttctgcttgt catccccttt gactgctggg agccagtcca ggagtgagac cggccagatg      480

aggctggcca agccggggag ctgctctctc atgaaacaag agctagaaac tcaggatggt      540

catcttggag ggaccaaggg gtgggccaca gccatggtgg gagtggcctg gacctgccct      600

gggccacact gaccctgata caggcatggc agaagaatgg gaatatttta tactgacaga      660

aatcagtaat atttatatat ttatattttt aaaatattta tttatttatt tatttaagtt      720

catattccat atttattcaa gatgttttac cgtaataatt attattaaaa atatgcttct      780

a                                                                      781


<210>  33
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  34
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  35
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  36
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Val Arg Leu Pro Leu Gln Cys Val Leu Trp Gly Cys Leu Leu Thr 
1               5                   10                  15      


Ala Val His Pro Glu Pro Pro Thr Ala Cys Arg Glu Lys Gln Tyr Leu 
            20                  25                  30          


Ile Asn Ser Gln Cys Cys Ser Leu Cys Gln Pro Gly Gln Lys Leu Val 
        35                  40                  45              


Ser Asp Cys Thr Glu Phe Thr Glu Thr Glu Cys Leu Pro Cys Gly Glu 
    50                  55                  60                  


Ser Glu Phe Leu Asp Thr Trp Asn Arg Glu Thr His Cys His Gln His 
65                  70                  75                  80  


Lys Tyr Cys Asp Pro Asn Leu Gly Leu Arg Val Gln Gln Lys Gly Thr 
                85                  90                  95      


Ser Glu Thr Asp Thr Ile Cys Thr Cys Glu Glu Gly Trp His Cys Thr 
            100                 105                 110         


Ser Glu Ala Cys Glu Ser Cys Val Leu His Arg Ser Cys Ser Pro Gly 
        115                 120                 125             


Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp Thr Ile Cys Glu 
    130                 135                 140                 


Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser Ala Phe Glu Lys 
145                 150                 155                 160 


Cys His Pro Trp Thr Ser Cys Glu Thr Lys Asp Leu Val Val Gln Gln 
                165                 170                 175     


Ala Gly Thr Asn Lys Thr Asp Val Val Cys Gly Pro Gln Asp Arg Leu 
            180                 185                 190         


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
        195                 200                 205             


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
    210                 215                 220                 


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
225                 230                 235                 240 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
                245                 250                 255     


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
            260                 265                 270         


Val Gln Glu Arg Gln 
        275         


