                         SEQUENCE LISTING

<110>  University of Delaware
       Colby, David  Wesley
       Morozova, Olga  Andreevna
 
<120>  DETECTION OF DISEASE-ASSOCIATED TAU PROTEIN CONFORMATIONS AND 
       APPLICATIONS THEREOF

<130>  UOD-451Wo

<150>  US 62/108,818
<151>  2015-01-28

<150>  US 62/195,915
<151>  2015-07-23

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
                245                 250                 255     


Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
            260                 265                 270         


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
        275                 280                 285             


Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro 
    290                 295                 300                 


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
305                 310                 315                 320 


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
                325                 330                 335     


Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser 
            340                 345                 350         


Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
        355                 360                 365             


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380     


<210>  2
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu Glu Ala Gly Ile Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala 
                85                  90                  95      


Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys 
            100                 105                 110         


Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala 
        115                 120                 125             


Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala 
    130                 135                 140                 


Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro 
145                 150                 155                 160 


Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr 
                165                 170                 175     


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
            180                 185                 190         


Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
        195                 200                 205             


Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu 
    210                 215                 220                 


Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln 
225                 230                 235                 240 


Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser 
                245                 250                 255     


Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro 
            260                 265                 270         


Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys 
        275                 280                 285             


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
    290                 295                 300                 


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg 
305                 310                 315                 320 


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly 
                325                 330                 335     


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn 
            340                 345                 350         


Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
        355                 360                 365             


Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser 
    370                 375                 380                 


Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala 
385                 390                 395                 400 


Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410         


<210>  3
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val 
    210                 215                 220                 


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
225                 230                 235                 240 


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
                245                 250                 255     


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
            260                 265                 270         


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
        275                 280                 285             


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
    290                 295                 300                 


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
305                 310                 315                 320 


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
                325                 330                 335     


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            340                 345                 350         


<210>  4
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Ala Glu Glu Ala 
        35                  40                  45              


Gly Ile Gly Asp Thr Pro Ser Leu Glu Asp Glu Ala Ala Gly His Val 
    50                  55                  60                  


Thr Gln Ala Arg Met Val Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp 
65                  70                  75                  80  


Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro 
                85                  90                  95      


Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg 
            100                 105                 110         


Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly 
        115                 120                 125             


Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
    130                 135                 140                 


Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
145                 150                 155                 160 


Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys 
                165                 170                 175     


Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met 
            180                 185                 190         


Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu 
        195                 200                 205             


Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu 
    210                 215                 220                 


Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
225                 230                 235                 240 


His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp 
                245                 250                 255     


Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
            260                 265                 270         


Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
        275                 280                 285             


Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His 
    290                 295                 300                 


Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
305                 310                 315                 320 


Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
                325                 330                 335     


Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn 
            340                 345                 350         


Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala 
        355                 360                 365             


Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    370                 375                 380             


<210>  5
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  6
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr 
        275                 280                 285             


Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly 
    290                 295                 300                 


Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln 
305                 310                 315                 320 


Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly 
                325                 330                 335     


Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys 
            340                 345                 350         


Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val 
        355                 360                 365             


Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly 
    370                 375                 380                 


Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu 
385                 390                 395                 400 


Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410 


<210>  7
<211>  343
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Met Ala Glu Pro Arg Gln Glu Phe Asp Thr Met Glu Asp Gln Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Met Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Asn Met Glu Asp Gln 
        35                  40                  45              


Ala Ala Gly His Val Thr Gln Ala Arg Val Ala Gly Val Ser Lys Asp 
    50                  55                  60                  


Arg Thr Gly Asn Asp Glu Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr 
65                  70                  75                  80  


Gly Ala Lys Ile Ala Thr Pro Arg Gly Ala Ala Thr Pro Gly Gln Lys 
                85                  90                  95      


Gly Thr Ser Asn Ala Thr Arg Ile Pro Ala Lys Thr Thr Pro Ser Pro 
            100                 105                 110         


Lys Thr Pro Pro Gly Ser Gly Glu Pro Pro Lys Ser Gly Glu Arg Ser 
        115                 120                 125             


Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
    130                 135                 140                 


Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
145                 150                 155                 160 


Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ala Ser Lys Ser Arg Leu 
                165                 170                 175     


Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Arg Ser Lys 
            180                 185                 190         


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
        195                 200                 205             


Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
    210                 215                 220                 


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu 
225                 230                 235                 240 


Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile 
                245                 250                 255     


Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys 
            260                 265                 270         


Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr 
        275                 280                 285             


Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp 
    290                 295                 300                 


Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp 
305                 310                 315                 320 


Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala 
                325                 330                 335     


Ser Leu Ala Lys Gln Gly Leu 
            340             


<210>  8
<211>  374
<212>  PRT
<213>  Rattus norvegicus

<400>  8

Met Ala Glu Pro Arg Gln Glu Phe Asp Thr Met Glu Asp Gln Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Met Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Asn Met Glu Asp Gln 
        35                  40                  45              


Ala Ala Gly His Val Thr Gln Ala Arg Val Ala Gly Val Ser Lys Asp 
    50                  55                  60                  


Arg Thr Gly Asn Asp Glu Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr 
65                  70                  75                  80  


Gly Ala Lys Ile Ala Thr Pro Arg Gly Ala Ala Thr Pro Gly Gln Lys 
                85                  90                  95      


Gly Thr Ser Asn Ala Thr Arg Ile Pro Ala Lys Thr Thr Pro Ser Pro 
            100                 105                 110         


Lys Thr Pro Pro Gly Ser Gly Glu Pro Pro Lys Ser Gly Glu Arg Ser 
        115                 120                 125             


Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
    130                 135                 140                 


Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala 
145                 150                 155                 160 


Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ala Ser Lys Ser Arg Leu 
                165                 170                 175     


Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Arg Ser Lys 
            180                 185                 190         


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
        195                 200                 205             


Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
    210                 215                 220                 


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln 
225                 230                 235                 240 


Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly 
                245                 250                 255     


Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val 
            260                 265                 270         


Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly 
        275                 280                 285             


Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile 
    290                 295                 300                 


Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp 
305                 310                 315                 320 


His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr 
                325                 330                 335     


Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met 
            340                 345                 350         


Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser 
        355                 360                 365             


Leu Ala Lys Gln Gly Leu 
    370                 


<210>  9
<211>  403
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Met Ala Glu Pro Arg Gln Glu Phe Asp Thr Met Glu Asp Gln Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Met Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Glu Ser Pro Pro Gln Pro Pro Ala Asp Asp Gly Ser Glu Glu Pro 
        35                  40                  45              


Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu 
    50                  55                  60                  


Glu Ala Gly Ile Gly Asp Thr Pro Asn Met Glu Asp Gln Ala Ala Gly 
65                  70                  75                  80  


His Val Thr Gln Ala Arg Val Ala Gly Val Ser Lys Asp Arg Thr Gly 
                85                  90                  95      


Asn Asp Glu Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Gly Ala Lys 
            100                 105                 110         


Ile Ala Thr Pro Arg Gly Ala Ala Thr Pro Gly Gln Lys Gly Thr Ser 
        115                 120                 125             


Asn Ala Thr Arg Ile Pro Ala Lys Thr Thr Pro Ser Pro Lys Thr Pro 
    130                 135                 140                 


Pro Gly Ser Gly Glu Pro Pro Lys Ser Gly Glu Arg Ser Gly Tyr Ser 
145                 150                 155                 160 


Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser 
                165                 170                 175     


Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg 
            180                 185                 190         


Thr Pro Pro Lys Ser Pro Ser Ala Ser Lys Ser Arg Leu Gln Thr Ala 
        195                 200                 205             


Pro Val Pro Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser 
    210                 215                 220                 


Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile 
225                 230                 235                 240 


Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys 
                245                 250                 255     


Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr 
            260                 265                 270         


Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly 
        275                 280                 285             


Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu 
    290                 295                 300                 


Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp 
305                 310                 315                 320 


Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His 
                325                 330                 335     


Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
            340                 345                 350         


Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg 
        355                 360                 365             


His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser 
    370                 375                 380                 


Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys 
385                 390                 395                 400 


Gln Gly Leu 
            


<210>  10
<211>  432
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met Ala Glu Pro Arg Gln Glu Phe Asp Thr Met Glu Asp Gln Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Met Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Glu Ser Pro Pro Gln Pro Pro Ala Asp Asp Gly Ser Glu Glu Pro 
        35                  40                  45              


Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val 
    50                  55                  60                  


Thr Ala Pro Leu Val Glu Glu Arg Ala Pro Asp Lys Gln Ala Thr Ala 
65                  70                  75                  80  


Gln Ser His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly 
                85                  90                  95      


Ile Gly Asp Thr Pro Asn Met Glu Asp Gln Ala Ala Gly His Val Thr 
            100                 105                 110         


Gln Ala Arg Val Ala Gly Val Ser Lys Asp Arg Thr Gly Asn Asp Glu 
        115                 120                 125             


Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Gly Ala Lys Ile Ala Thr 
    130                 135                 140                 


Pro Arg Gly Ala Ala Thr Pro Gly Gln Lys Gly Thr Ser Asn Ala Thr 
145                 150                 155                 160 


Arg Ile Pro Ala Lys Thr Thr Pro Ser Pro Lys Thr Pro Pro Gly Ser 
                165                 170                 175     


Gly Glu Pro Pro Lys Ser Gly Glu Arg Ser Gly Tyr Ser Ser Pro Gly 
            180                 185                 190         


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
        195                 200                 205             


Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
    210                 215                 220                 


Lys Ser Pro Ser Ala Ser Lys Ser Arg Leu Gln Thr Ala Pro Val Pro 
225                 230                 235                 240 


Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser Thr Glu Asn 
                245                 250                 255     


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys 
            260                 265                 270         


Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile 
        275                 280                 285             


Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val 
    290                 295                 300                 


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
305                 310                 315                 320 


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
                325                 330                 335     


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
            340                 345                 350         


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
        355                 360                 365             


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
    370                 375                 380                 


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
385                 390                 395                 400 


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
                405                 410                 415     


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            420                 425                 430         


<210>  11
<211>  469
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Met Ala Glu Pro Arg Gln Glu Phe Asp Thr Met Glu Asp Gln Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Met Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Glu Ser Pro Pro Gln Pro Pro Ala Asp Asp Gly Ser Glu Glu Pro 
        35                  40                  45              


Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu 
    50                  55                  60                  


Glu Ala Gly Ile Gly Asp Thr Pro Asn Met Glu Asp Gln Ala Ala Gly 
65                  70                  75                  80  


His Val Thr Gln Ala Arg Val Ala Gly Val Ser Lys Asp Arg Thr Gly 
                85                  90                  95      


Asn Asp Glu Lys Lys Ala Lys Thr Ser Thr Pro Ser Cys Ala Lys Thr 
            100                 105                 110         


Pro Ser Asn Arg Pro Cys Leu Ser Pro Thr Arg Pro Thr Pro Gly Ser 
        115                 120                 125             


Ser Asp Pro Leu Ile Lys Pro Ser Ser Pro Ala Val Cys Pro Glu Pro 
    130                 135                 140                 


Ala Thr Ser Pro Lys Tyr Val Ser Ser Val Thr Pro Arg Asn Gly Ser 
145                 150                 155                 160 


Pro Gly Thr Lys Gln Met Lys Leu Lys Gly Ala Asp Gly Lys Thr Gly 
                165                 170                 175     


Ala Lys Ile Ala Thr Pro Arg Gly Ala Ala Thr Pro Gly Gln Lys Gly 
            180                 185                 190         


Thr Ser Asn Ala Thr Arg Ile Pro Ala Lys Thr Thr Pro Ser Pro Lys 
        195                 200                 205             


Thr Pro Pro Gly Ser Gly Glu Pro Pro Lys Ser Gly Glu Arg Ser Gly 
    210                 215                 220                 


Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr 
225                 230                 235                 240 


Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val 
                245                 250                 255     


Val Arg Thr Pro Pro Lys Ser Pro Ser Ala Ser Lys Ser Arg Leu Gln 
            260                 265                 270         


Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile 
        275                 280                 285             


Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln 
    290                 295                 300                 


Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly 
305                 310                 315                 320 


Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile 
                325                 330                 335     


Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser 
            340                 345                 350         


Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys 
        355                 360                 365             


Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser 
    370                 375                 380                 


Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu 
385                 390                 395                 400 


Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His 
                405                 410                 415     


Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser 
            420                 425                 430         


Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val 
        435                 440                 445             


Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu 
    450                 455                 460                 


Ala Lys Gln Gly Leu 
465                 


<210>  12
<211>  498
<212>  PRT
<213>  Rattus norvegicus

<400>  12

Met Ala Glu Pro Arg Gln Glu Phe Asp Thr Met Glu Asp Gln Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Met Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Glu Ser Pro Pro Gln Pro Pro Ala Asp Asp Gly Ser Glu Glu Pro 
        35                  40                  45              


Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val 
    50                  55                  60                  


Thr Ala Pro Leu Val Glu Glu Arg Ala Pro Asp Lys Gln Ala Thr Ala 
65                  70                  75                  80  


Gln Ser His Thr Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly 
                85                  90                  95      


Ile Gly Asp Thr Pro Asn Met Glu Asp Gln Ala Ala Gly His Val Thr 
            100                 105                 110         


Gln Ala Arg Val Ala Gly Val Ser Lys Asp Arg Thr Gly Asn Asp Glu 
        115                 120                 125             


Lys Lys Ala Lys Thr Ser Thr Pro Ser Cys Ala Lys Thr Pro Ser Asn 
    130                 135                 140                 


Arg Pro Cys Leu Ser Pro Thr Arg Pro Thr Pro Gly Ser Ser Asp Pro 
145                 150                 155                 160 


Leu Ile Lys Pro Ser Ser Pro Ala Val Cys Pro Glu Pro Ala Thr Ser 
                165                 170                 175     


Pro Lys Tyr Val Ser Ser Val Thr Pro Arg Asn Gly Ser Pro Gly Thr 
            180                 185                 190         


Lys Gln Met Lys Leu Lys Gly Ala Asp Gly Lys Thr Gly Ala Lys Ile 
        195                 200                 205             


Ala Thr Pro Arg Gly Ala Ala Thr Pro Gly Gln Lys Gly Thr Ser Asn 
    210                 215                 220                 


Ala Thr Arg Ile Pro Ala Lys Thr Thr Pro Ser Pro Lys Thr Pro Pro 
225                 230                 235                 240 


Gly Ser Gly Glu Pro Pro Lys Ser Gly Glu Arg Ser Gly Tyr Ser Ser 
                245                 250                 255     


Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu 
            260                 265                 270         


Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr 
        275                 280                 285             


Pro Pro Lys Ser Pro Ser Ala Ser Lys Ser Arg Leu Gln Thr Ala Pro 
    290                 295                 300                 


Val Pro Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser Thr 
305                 310                 315                 320 


Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn 
                325                 330                 335     


Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp 
            340                 345                 350         


Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys 
        355                 360                 365             


Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn 
    370                 375                 380                 


Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys 
385                 390                 395                 400 


Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn 
                405                 410                 415     


Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys 
            420                 425                 430         


Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu 
        435                 440                 445             


Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His 
    450                 455                 460                 


Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro 
465                 470                 475                 480 


Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln 
                485                 490                 495     


Gly Leu 
        


<210>  13
<211>  372
<212>  PRT
<213>  Mus musculus

<400>  13

Met Ala Asp Pro Arg Gln Glu Phe Asp Thr Met Glu Asp His Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Leu Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Asn Gln Glu Asp Gln 
        35                  40                  45              


Ala Ala Gly His Val Thr Gln Ala Arg Val Ala Ser Lys Asp Arg Thr 
    50                  55                  60                  


Gly Asn Asp Glu Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Gly Ala 
65                  70                  75                  80  


Lys Ile Ala Thr Pro Arg Gly Ala Ala Ser Pro Ala Gln Lys Gly Thr 
                85                  90                  95      


Ser Asn Ala Thr Arg Ile Pro Ala Lys Thr Thr Pro Ser Pro Lys Thr 
            100                 105                 110         


Pro Pro Gly Ser Gly Glu Pro Pro Lys Ser Gly Glu Arg Ser Gly Tyr 
        115                 120                 125             


Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro 
    130                 135                 140                 


Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val 
145                 150                 155                 160 


Arg Thr Pro Pro Lys Ser Pro Ser Ala Ser Lys Ser Arg Leu Gln Thr 
                165                 170                 175     


Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly 
            180                 185                 190         


Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile 
        195                 200                 205             


Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser 
    210                 215                 220                 


Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val 
225                 230                 235                 240 


Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu 
                245                 250                 255     


Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser 
            260                 265                 270         


Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu 
        275                 280                 285             


Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr 
    290                 295                 300                 


His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly 
305                 310                 315                 320 


Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro 
                325                 330                 335     


Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp 
            340                 345                 350         


Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala 
        355                 360                 365             


Lys Gln Gly Leu 
    370         


<210>  14
<211>  341
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ala Asp Pro Arg Gln Glu Phe Asp Thr Met Glu Asp His Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Leu Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Asn Gln Glu Asp Gln 
        35                  40                  45              


Ala Ala Gly His Val Thr Gln Ala Arg Val Ala Ser Lys Asp Arg Thr 
    50                  55                  60                  


Gly Asn Asp Glu Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Gly Ala 
65                  70                  75                  80  


Lys Ile Ala Thr Pro Arg Gly Ala Ala Ser Pro Ala Gln Lys Gly Thr 
                85                  90                  95      


Ser Asn Ala Thr Arg Ile Pro Ala Lys Thr Thr Pro Ser Pro Lys Thr 
            100                 105                 110         


Pro Pro Gly Ser Gly Glu Pro Pro Lys Ser Gly Glu Arg Ser Gly Tyr 
        115                 120                 125             


Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro 
    130                 135                 140                 


Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val 
145                 150                 155                 160 


Arg Thr Pro Pro Lys Ser Pro Ser Ala Ser Lys Ser Arg Leu Gln Thr 
                165                 170                 175     


Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly 
            180                 185                 190         


Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile 
        195                 200                 205             


Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser 
    210                 215                 220                 


Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys 
225                 230                 235                 240 


Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser 
                245                 250                 255     


Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu 
            260                 265                 270         


Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His 
        275                 280                 285             


Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser 
    290                 295                 300                 


Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val 
305                 310                 315                 320 


Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu 
                325                 330                 335     


Ala Lys Gln Gly Leu 
            340     


<210>  15
<211>  430
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ala Asp Pro Arg Gln Glu Phe Asp Thr Met Glu Asp His Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Leu Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Glu Ser Pro Pro Gln Pro Pro Ala Asp Asp Gly Ala Glu Glu Pro 
        35                  40                  45              


Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val 
    50                  55                  60                  


Thr Ala Pro Leu Val Asp Glu Arg Ala Pro Asp Lys Gln Ala Ala Ala 
65                  70                  75                  80  


Gln Pro His Thr Glu Ile Pro Glu Gly Ile Thr Ala Glu Glu Ala Gly 
                85                  90                  95      


Ile Gly Asp Thr Pro Asn Gln Glu Asp Gln Ala Ala Gly His Val Thr 
            100                 105                 110         


Gln Ala Arg Val Ala Ser Lys Asp Arg Thr Gly Asn Asp Glu Lys Lys 
        115                 120                 125             


Ala Lys Gly Ala Asp Gly Lys Thr Gly Ala Lys Ile Ala Thr Pro Arg 
    130                 135                 140                 


Gly Ala Ala Ser Pro Ala Gln Lys Gly Thr Ser Asn Ala Thr Arg Ile 
145                 150                 155                 160 


Pro Ala Lys Thr Thr Pro Ser Pro Lys Thr Pro Pro Gly Ser Gly Glu 
                165                 170                 175     


Pro Pro Lys Ser Gly Glu Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro 
            180                 185                 190         


Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro 
        195                 200                 205             


Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser 
    210                 215                 220                 


Pro Ser Ala Ser Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro 
225                 230                 235                 240 


Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys 
                245                 250                 255     


His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp 
            260                 265                 270         


Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
        275                 280                 285             


Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu 
    290                 295                 300                 


Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys 
305                 310                 315                 320 


Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys 
                325                 330                 335     


Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val 
            340                 345                 350         


Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg 
        355                 360                 365             


Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys 
    370                 375                 380                 


Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val 
385                 390                 395                 400 


Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr 
                405                 410                 415     


Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            420                 425                 430 


<210>  16
<211>  350
<212>  PRT
<213>  Mus musculus

<400>  16

Met Ala Asp Pro Arg Gln Glu Phe Asp Thr Met Glu Asp His Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Leu Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Ala Arg Val Ala Ser Lys Asp Arg Thr Gly Asn Asp Glu Lys Lys 
        35                  40                  45              


Ala Lys Gly Ala Asp Gly Lys Thr Gly Ala Lys Ile Ala Thr Pro Arg 
    50                  55                  60                  


Gly Ala Ala Ser Pro Ala Gln Lys Gly Thr Ser Asn Ala Thr Arg Ile 
65                  70                  75                  80  


Pro Ala Lys Thr Thr Pro Ser Pro Lys Thr Pro Pro Gly Ser Gly Glu 
                85                  90                  95      


Pro Pro Lys Ser Gly Glu Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro 
            100                 105                 110         


Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro 
        115                 120                 125             


Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser 
    130                 135                 140                 


Pro Ser Ala Ser Lys Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro 
145                 150                 155                 160 


Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys 
                165                 170                 175     


His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp 
            180                 185                 190         


Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
        195                 200                 205             


Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu 
    210                 215                 220                 


Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys 
225                 230                 235                 240 


Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys 
                245                 250                 255     


Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val 
            260                 265                 270         


Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg 
        275                 280                 285             


Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys 
    290                 295                 300                 


Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val 
305                 310                 315                 320 


Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr 
                325                 330                 335     


Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            340                 345                 350 


<210>  17
<211>  364
<212>  PRT
<213>  Mus musculus

<400>  17

Met Ala Asp Pro Arg Gln Glu Phe Asp Thr Met Glu Asp His Ala Gly 
1               5                   10                  15      


Asp Tyr Thr Leu Leu Gln Asp Gln Glu Gly Asp Met Asp His Gly Leu 
            20                  25                  30          


Lys Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Asn Gln Glu Asp Gln 
        35                  40                  45              


Ala Ala Gly His Val Thr Gln Ala Arg Val Ala Ser Lys Asp Arg Thr 
    50                  55                  60                  


Gly Asn Asp Glu Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr Gly Ala 
65                  70                  75                  80  


Lys Ile Ala Thr Pro Arg Gly Ala Ala Ser Pro Ala Gln Lys Gly Thr 
                85                  90                  95      


Ser Asn Ala Thr Arg Ile Pro Ala Lys Thr Thr Pro Ser Pro Lys Thr 
            100                 105                 110         


Pro Pro Gly Ser Gly Glu Pro Pro Lys Ser Gly Glu Arg Ser Gly Tyr 
        115                 120                 125             


Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro 
    130                 135                 140                 


Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val 
145                 150                 155                 160 


Arg Thr Pro Pro Lys Ser Pro Ser Ala Ser Lys Ser Arg Leu Gln Thr 
                165                 170                 175     


Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly 
            180                 185                 190         


Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile 
        195                 200                 205             


Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser 
    210                 215                 220                 


Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys 
225                 230                 235                 240 


Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser 
                245                 250                 255     


Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu 
            260                 265                 270         


Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His 
        275                 280                 285             


Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser 
    290                 295                 300                 


Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val 
305                 310                 315                 320 


Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu 
                325                 330                 335     


Ala Lys Gln Gly Lys Ala Ala Leu Leu Ser Ser Gln Val Trp Asn Tyr 
            340                 345                 350         


Ser His Asp Leu Ala Thr Ile Thr Asp Leu Gly Leu 
        355                 360                 


<210>  18
<211>  448
<212>  PRT
<213>  Bos taurus

<400>  18

Met Ala Glu Pro Arg Gln Glu Phe Asp Val Met Glu Asp His Ala Gln 
1               5                   10                  15      


Gly Asp Tyr Thr Leu Gln Asp Gln Glu Gly Asp Met Asp Pro Gly Leu 
            20                  25                  30          


Lys Glu Ser Pro Leu Gln Thr Pro Ala Asp Asp Gly Ser Glu Glu Pro 
        35                  40                  45              


Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Ala 
    50                  55                  60                  


Thr Ala Pro Leu Val Asp Glu Gly Ala Pro Gly Glu Gln Ala Ala Ala 
65                  70                  75                  80  


Gln Ala Pro Ala Glu Ile Pro Glu Gly Thr Ala Ala Glu Glu Ala Gly 
                85                  90                  95      


Ile Gly Asp Thr Ser Asn Leu Glu Asp Gln Ala Ala Gly His Val Thr 
            100                 105                 110         


Gln Ala Arg Met Val Ser Lys Gly Lys Asp Gly Thr Gly Pro Asp Asp 
        115                 120                 125             


Lys Lys Thr Lys Gly Ala Asp Gly Lys Pro Gly Thr Lys Ile Ala Thr 
    130                 135                 140                 


Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala Asn Ala Thr 
145                 150                 155                 160 


Arg Ile Pro Ala Lys Thr Thr Pro Thr Pro Lys Thr Ser Pro Ala Thr 
                165                 170                 175     


Met Gln Val Gln Lys Lys Pro Pro Pro Ala Gly Ala Lys Ser Glu Arg 
            180                 185                 190         


Gly Glu Ser Gly Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
        195                 200                 205             


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
    210                 215                 220                 


Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
225                 230                 235                 240 


Lys Ser Pro Ser Ala Ala Lys Ser Arg Leu Gln Ala Ala Pro Gly Pro 
                245                 250                 255     


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn 
            260                 265                 270         


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys 
        275                 280                 285             


Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile 
    290                 295                 300                 


Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val 
305                 310                 315                 320 


Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
                325                 330                 335     


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
            340                 345                 350         


Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Thr 
        355                 360                 365             


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
    370                 375                 380                 


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
385                 390                 395                 400 


Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His Leu Ser 
                405                 410                 415     


Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro Gln Leu 
            420                 425                 430         


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440                 445             


<210>  19
<211>  370
<212>  PRT
<213>  Bos taurus

<400>  19

Met Ala Glu Pro Arg Gln Glu Phe Asp Val Met Glu Asp His Ala Gln 
1               5                   10                  15      


Gly Asp Tyr Thr Leu Gln Asp Gln Glu Gly Asp Met Asp Pro Gly Leu 
            20                  25                  30          


Lys Glu Ser Pro Leu Gln Thr Pro Ala Asp Asp Gly Ser Glu Glu Pro 
        35                  40                  45              


Gly Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr Ala Glu Ala Glu 
    50                  55                  60                  


Glu Ala Gly Ile Gly Asp Thr Ser Asn Leu Glu Asp Gln Ala Ala Gly 
65                  70                  75                  80  


His Val Thr Gln Ala Arg Met Val Ser Lys Gly Lys Asp Gly Thr Gly 
                85                  90                  95      


Pro Asp Asp Lys Lys Thr Lys Gly Ala Asp Gly Lys Pro Gly Thr Lys 
            100                 105                 110         


Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln Ala 
        115                 120                 125             


Asn Ala Thr Arg Ile Pro Ala Lys Thr Thr Pro Thr Pro Lys Thr Ser 
    130                 135                 140                 


Pro Gly Glu Ser Gly Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
145                 150                 155                 160 


Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro 
                165                 170                 175     


Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro 
            180                 185                 190         


Pro Lys Ser Pro Ser Ala Ala Lys Ser Arg Leu Gln Ala Ala Pro Gly 
        195                 200                 205             


Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu 
    210                 215                 220                 


Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Val Tyr Lys 
225                 230                 235                 240 


Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu Gly Asn 
                245                 250                 255     


Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys 
            260                 265                 270         


Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu Asp Asn 
        275                 280                 285             


Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys 
    290                 295                 300                 


Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu 
305                 310                 315                 320 


Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro Arg His 
                325                 330                 335     


Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp Ser Pro 
            340                 345                 350         


Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln 
        355                 360                 365             


Gly Leu 
    370 


<210>  20
<211>  403
<212>  PRT
<213>  Xenopus tropicalis

<400>  20

Met Ala Asp His Tyr Gln Asp Tyr Asp Ser Val Gly Asp His Thr Arg 
1               5                   10                  15      


Asp Gly Ser Ala Gln Gln Ile Tyr Thr Gly Gly Ser Gly Asp His Ile 
            20                  25                  30          


Leu Glu Ser Ser Gln Glu Ser Val Ile Arg Leu Pro Thr Ala Ala His 
        35                  40                  45              


Gly Asp Asp Val Ala Ser Val Gln Glu Asp Leu Ala Asn Gly Glu Ala 
    50                  55                  60                  


Val Arg Ser Gln Gly His Ala Gly Ile Pro Glu Gly Thr Thr Ala His 
65                  70                  75                  80  


Glu Gln Glu Lys His Glu Thr Asp Ser Gln Glu Lys Gly Ala Gln Glu 
                85                  90                  95      


Ala Gly Gly Pro Glu Ser Ala Lys Ser Gln Leu Ser Ala Ser Arg Asn 
            100                 105                 110         


Ala Thr Ser Ala Ser Arg Ile Pro Ala Lys Thr Ser Ser Ile Pro Lys 
        115                 120                 125             


Thr Pro Pro Ser Ala Val Arg Arg Asp Gln Arg Lys Pro Pro Pro Ser 
    130                 135                 140                 


Gly Ala Lys Pro Asp Arg Glu Ser Pro Lys Ser Gly Glu Arg Ser Gly 
145                 150                 155                 160 


Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Thr Gly Arg Ser Ser Ser 
                165                 170                 175     


Gln Thr Pro Pro Thr Arg Glu Pro Lys Lys Ile Ala Val Ile Arg Thr 
            180                 185                 190         


Pro Pro Lys Ser Pro Ala Ser Ala Lys Ser Arg Leu Gln Pro Val Thr 
        195                 200                 205             


Ser Pro Ala Ala Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly 
    210                 215                 220                 


Ser Ile Asp Asn Ile Arg His Gln Pro Gly Gly Gly Lys Val Gln Ile 
225                 230                 235                 240 


Val His Lys Lys Ile Asp Leu Ser Ser Val Gln Ser Lys Cys Gly Ser 
                245                 250                 255     


Lys Asp Asn Leu Lys His Met Pro Gly Gly Gly Thr Ile Gln Ile Thr 
            260                 265                 270         


His Lys Pro Ile Asp Leu Thr His Ile Thr Ser Lys Cys Gly Ser Phe 
        275                 280                 285             


Gly Asn Ile His His Arg Pro Gly Gly Gly Asn Val Glu Val Lys Ser 
    290                 295                 300                 


Glu Lys Leu Glu Phe Asp Lys Ile Gln Ser Lys Ile Gly Ser Leu Asp 
305                 310                 315                 320 


Asn Ile Thr His Thr Pro Gly Gly Gly Ala Lys Lys Ile Glu Ser His 
                325                 330                 335     


Lys Leu Met Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
            340                 345                 350         


Glu Ile Val Tyr Lys Ser Pro Gly Gln Ser Gly Glu Thr Ser Pro Arg 
        355                 360                 365             


Arg Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn Met Thr Asp Ser 
    370                 375                 380                 


Pro Gln Leu Ser Thr Leu Ala Asp Gln Val Ser Ala Ser Leu Ala Lys 
385                 390                 395                 400 


Gln Gly Leu 
            


<210>  21
<211>  421
<212>  PRT
<213>  Xenopus tropicalis

<400>  21

Met Ala Asp His Tyr Gln Asp Tyr Asp Ser Val Gly Asp His Thr Arg 
1               5                   10                  15      


Asp Gly Ser Ala Gln Gln Ile Tyr Thr Gly Gly Ser Gly Asp His Ile 
            20                  25                  30          


Leu Glu Ser Ser Gln Glu Ser Val Ile Arg Leu Pro Thr Ala Ala His 
        35                  40                  45              


Gly Asp Asp Val Ala Ser Val Gln Glu Asp Leu Ala Asn Gly Glu Ala 
    50                  55                  60                  


Val Arg Ser Gln Gly His Ala Gly Ile Pro Glu Gly Thr Thr Ala Glu 
65                  70                  75                  80  


Glu Ala Gly Val Gly His Thr Pro Ser Gln Gln Asp Arg Ala Ala Ala 
                85                  90                  95      


His Glu Gln Glu Lys His Glu Thr Asp Ser Gln Glu Lys Gly Ala Gln 
            100                 105                 110         


Glu Ala Gly Gly Pro Glu Ser Ala Lys Ser Gln Leu Ser Ala Ser Arg 
        115                 120                 125             


Asn Ala Thr Ser Ala Ser Arg Ile Pro Ala Lys Thr Ser Ser Ile Pro 
    130                 135                 140                 


Lys Thr Pro Pro Ser Ala Val Arg Arg Asp Gln Arg Lys Pro Pro Pro 
145                 150                 155                 160 


Ser Gly Ala Lys Pro Asp Arg Ala Glu Ser Pro Lys Ser Gly Glu Arg 
                165                 170                 175     


Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Thr Gly Arg Ser 
            180                 185                 190         


Ser Ser Gln Thr Pro Pro Thr Arg Glu Pro Lys Lys Ile Ala Val Ile 
        195                 200                 205             


Arg Thr Pro Pro Lys Ser Pro Ala Ser Ala Lys Ser Arg Leu Gln Pro 
    210                 215                 220                 


Val Thr Ser Pro Ala Ala Met Pro Asp Leu Lys Asn Val Arg Ser Lys 
225                 230                 235                 240 


Ile Gly Ser Ile Asp Asn Ile Arg His Gln Pro Gly Gly Gly Lys Val 
                245                 250                 255     


Gln Ile Val His Lys Lys Ile Asp Leu Ser Ser Val Gln Ser Lys Cys 
            260                 265                 270         


Gly Ser Lys Asp Asn Leu Lys His Met Pro Gly Gly Gly Thr Ile Gln 
        275                 280                 285             


Ile Thr His Lys Pro Ile Asp Leu Thr His Ile Thr Ser Lys Cys Gly 
    290                 295                 300                 


Ser Phe Gly Asn Ile His His Arg Pro Gly Gly Gly Asn Val Glu Val 
305                 310                 315                 320 


Lys Ser Glu Lys Leu Glu Phe Asp Lys Ile Gln Ser Lys Ile Gly Ser 
                325                 330                 335     


Leu Asp Asn Ile Thr His Thr Pro Gly Gly Gly Ala Lys Lys Ile Glu 
            340                 345                 350         


Ser His Lys Leu Met Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His 
        355                 360                 365             


Gly Ala Glu Ile Val Tyr Lys Ser Pro Gly Gln Ser Gly Glu Thr Ser 
    370                 375                 380                 


Pro Arg Arg Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn Met Thr 
385                 390                 395                 400 


Asp Ser Pro Gln Leu Ser Thr Leu Ala Asp Gln Val Ser Ala Ser Leu 
                405                 410                 415     


Ala Lys Gln Gly Leu 
            420     


<210>  22
<211>  465
<212>  PRT
<213>  Xenopus tropicalis

<400>  22

Met Ala Asp His Tyr Gln Asp Tyr Asp Ser Val Gly Asp His Thr Arg 
1               5                   10                  15      


Asp Gly Ser Ala Gln Gln Ile Tyr Thr Gly Gly Ser Gly Asp His Ile 
            20                  25                  30          


Leu Glu Ser Ser Gln Glu Ser Val Ile Arg Leu Pro Thr Ala Ala His 
        35                  40                  45              


Gly Asp Asp Val Ala Ser Val Gln Glu Asp Leu Ala Asn Gly Glu Ala 
    50                  55                  60                  


Val Arg Ser Gln Gly His Ala Gly Ile Pro Glu Gly Thr Thr Ala His 
65                  70                  75                  80  


Glu Gln Glu Lys His Glu Thr Asp Ser Gln Glu Lys Gly Ala Gln Ile 
                85                  90                  95      


Ser Thr Lys His Pro Pro Ala Lys Asn Ala Lys Ser Arg Leu Tyr Thr 
            100                 105                 110         


Val Pro Gln Lys Ser Pro Ser Ile Thr Ser Lys Ser Pro Ser Ser Pro 
        115                 120                 125             


Ala Ala Ser Ser Val Arg Ser Ile Gln Arg Thr Ser Leu Gly Ala Val 
    130                 135                 140                 


Gly Gln Pro Gly Val Thr Ala Arg Leu His Arg Ala Lys Glu Ala Gly 
145                 150                 155                 160 


Gly Pro Glu Ser Ala Lys Ser Gln Leu Ser Ala Ser Arg Asn Ala Thr 
                165                 170                 175     


Ser Ala Ser Arg Ile Pro Ala Lys Thr Ser Ser Ile Pro Lys Thr Pro 
            180                 185                 190         


Pro Ser Ala Val Arg Arg Asp Gln Arg Lys Pro Pro Pro Ser Gly Ala 
        195                 200                 205             


Lys Pro Asp Arg Glu Ser Pro Lys Ser Gly Glu Arg Ser Gly Tyr Ser 
    210                 215                 220                 


Ser Pro Gly Ser Pro Gly Thr Pro Thr Gly Arg Ser Ser Ser Gln Thr 
225                 230                 235                 240 


Pro Pro Thr Arg Glu Pro Lys Lys Ile Ala Val Ile Arg Thr Pro Pro 
                245                 250                 255     


Lys Ser Pro Ala Ser Ala Lys Ser Arg Leu Gln Pro Val Thr Ser Pro 
            260                 265                 270         


Ala Ala Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser Ile 
        275                 280                 285             


Asp Asn Ile Arg His Gln Pro Gly Gly Gly Lys Val Gln Ile Val His 
    290                 295                 300                 


Lys Lys Ile Asp Leu Ser Ser Val Gln Ser Lys Cys Gly Ser Lys Asp 
305                 310                 315                 320 


Asn Leu Lys His Met Pro Gly Gly Gly Thr Ile Gln Ile Thr His Lys 
                325                 330                 335     


Pro Ile Asp Leu Thr His Ile Thr Ser Lys Cys Gly Ser Phe Gly Asn 
            340                 345                 350         


Ile His His Arg Pro Gly Gly Gly Asn Val Glu Val Lys Ser Glu Lys 
        355                 360                 365             


Leu Glu Phe Asp Lys Ile Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
    370                 375                 380                 


Thr His Thr Pro Gly Gly Gly Ala Lys Lys Ile Glu Ser His Lys Leu 
385                 390                 395                 400 


Met Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile 
                405                 410                 415     


Val Tyr Lys Ser Pro Gly Gln Ser Gly Glu Thr Ser Pro Arg Arg Leu 
            420                 425                 430         


Ser Asn Val Ser Ser Ser Gly Ser Ile Asn Met Thr Asp Ser Pro Gln 
        435                 440                 445             


Leu Ser Thr Leu Ala Asp Gln Val Ser Ala Ser Leu Ala Lys Gln Gly 
    450                 455                 460                 


Leu 
465 


<210>  23
<211>  482
<212>  PRT
<213>  Xenopus tropicalis

<400>  23

Met Ala Asp His Tyr Gln Asp Tyr Asp Ser Val Gly Asp His Thr Arg 
1               5                   10                  15      


Asp Gly Ser Ala Gln Gln Ile Tyr Thr Gly Gly Ser Gly Asp His Ile 
            20                  25                  30          


Leu Glu Ser Ser Gln Glu Ser Val Ile Arg Leu Pro Thr Ala Ala His 
        35                  40                  45              


Gly Asp Asp Val Ala Ser Val Gln Glu Asp Leu Ala Asn Gly Glu Ala 
    50                  55                  60                  


Val Arg Ser Gln Gly His Ala Gly Ile Pro Glu Gly Thr Thr Ala Glu 
65                  70                  75                  80  


Glu Ala Gly Val Gly His Thr Pro Ser Gln Gln Asp Arg Ala Ala Ala 
                85                  90                  95      


His Glu Gln Glu Lys His Glu Thr Asp Ser Gln Glu Lys Gly Ala Gln 
            100                 105                 110         


Ile Ser Thr Lys His Pro Pro Ala Lys Asn Ala Lys Ser Arg Leu Tyr 
        115                 120                 125             


Thr Val Pro Gln Lys Ser Pro Ser Ile Thr Ser Lys Ser Pro Ser Ser 
    130                 135                 140                 


Pro Ala Ala Ser Ser Val Arg Ser Ile Gln Arg Thr Ser Leu Gly Ala 
145                 150                 155                 160 


Val Gly Gln Pro Gly Val Thr Ala Arg Leu His Arg Ala Lys Glu Ala 
                165                 170                 175     


Gly Gly Pro Glu Ser Ala Lys Ser Gln Leu Ser Ala Ser Arg Asn Ala 
            180                 185                 190         


Thr Ser Ala Ser Arg Ile Pro Ala Lys Thr Ser Ser Ile Pro Lys Thr 
        195                 200                 205             


Pro Pro Ser Ala Val Arg Arg Asp Gln Arg Lys Pro Pro Pro Ser Gly 
    210                 215                 220                 


Ala Lys Pro Asp Arg Glu Ser Pro Lys Ser Gly Glu Arg Ser Gly Tyr 
225                 230                 235                 240 


Ser Ser Pro Gly Ser Pro Gly Thr Pro Thr Gly Arg Ser Ser Ser Gln 
                245                 250                 255     


Thr Pro Pro Thr Arg Glu Pro Lys Lys Ile Ala Val Ile Arg Thr Pro 
            260                 265                 270         


Pro Lys Ser Pro Ala Ser Ala Lys Ser Arg Leu Gln Pro Val Thr Ser 
        275                 280                 285             


Pro Ala Ala Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser 
    290                 295                 300                 


Ile Asp Asn Ile Arg His Gln Pro Gly Gly Gly Lys Val Gln Ile Val 
305                 310                 315                 320 


His Lys Lys Ile Asp Leu Ser Ser Val Gln Ser Lys Cys Gly Ser Lys 
                325                 330                 335     


Asp Asn Leu Lys His Met Pro Gly Gly Gly Thr Ile Gln Ile Thr His 
            340                 345                 350         


Lys Pro Ile Asp Leu Thr His Ile Thr Ser Lys Cys Gly Ser Phe Gly 
        355                 360                 365             


Asn Ile His His Arg Pro Gly Gly Gly Asn Val Glu Val Lys Ser Glu 
    370                 375                 380                 


Lys Leu Glu Phe Asp Lys Ile Gln Ser Lys Ile Gly Ser Leu Asp Asn 
385                 390                 395                 400 


Ile Thr His Thr Pro Gly Gly Gly Ala Lys Lys Ile Glu Ser His Lys 
                405                 410                 415     


Leu Met Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu 
            420                 425                 430         


Ile Val Tyr Lys Ser Pro Gly Gln Ser Gly Glu Thr Ser Pro Arg Arg 
        435                 440                 445             


Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn Met Thr Asp Ser Pro 
    450                 455                 460                 


Gln Leu Ser Thr Leu Ala Asp Gln Val Ser Ala Ser Leu Ala Lys Gln 
465                 470                 475                 480 


Gly Leu 
        


<210>  24
<211>  483
<212>  PRT
<213>  Xenopus tropicalis

<400>  24

Met Ala Asp His Tyr Gln Asp Tyr Asp Ser Val Gly Asp His Thr Arg 
1               5                   10                  15      


Asp Gly Ser Ala Gln Gln Ile Tyr Thr Gly Gly Ser Gly Asp His Ile 
            20                  25                  30          


Leu Glu Ser Ser Gln Glu Ser Val Ile Arg Leu Pro Thr Ala Ala His 
        35                  40                  45              


Gly Asp Asp Val Ala Ser Val Gln Glu Asp Leu Ala Asn Gly Glu Ala 
    50                  55                  60                  


Val Arg Ser Gln Gly His Ala Gly Ile Pro Glu Gly Thr Thr Ala Glu 
65                  70                  75                  80  


Glu Ala Gly Val Gly His Thr Pro Ser Gln Gln Asp Arg Ala Ala Ala 
                85                  90                  95      


His Glu Gln Glu Lys His Glu Thr Asp Ser Gln Glu Lys Gly Ala Gln 
            100                 105                 110         


Ile Ser Thr Lys His Pro Pro Ala Lys Asn Ala Lys Ser Arg Leu Tyr 
        115                 120                 125             


Thr Val Pro Gln Lys Ser Pro Ser Ile Thr Ser Lys Ser Pro Ser Ser 
    130                 135                 140                 


Pro Ala Ala Ser Ser Val Arg Ser Ile Gln Arg Thr Ser Leu Gly Ala 
145                 150                 155                 160 


Val Gly Gln Pro Gly Val Thr Ala Arg Leu His Arg Ala Lys Glu Ala 
                165                 170                 175     


Gly Gly Pro Glu Ser Ala Lys Ser Gln Leu Ser Ala Ser Arg Asn Ala 
            180                 185                 190         


Thr Ser Ala Ser Arg Ile Pro Ala Lys Thr Ser Ser Ile Pro Lys Thr 
        195                 200                 205             


Pro Pro Ser Ala Val Arg Arg Asp Gln Arg Lys Pro Pro Pro Ser Gly 
    210                 215                 220                 


Ala Lys Pro Asp Arg Ala Glu Ser Pro Lys Ser Gly Glu Arg Ser Gly 
225                 230                 235                 240 


Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Thr Gly Arg Ser Ser Ser 
                245                 250                 255     


Gln Thr Pro Pro Thr Arg Glu Pro Lys Lys Ile Ala Val Ile Arg Thr 
            260                 265                 270         


Pro Pro Lys Ser Pro Ala Ser Ala Lys Ser Arg Leu Gln Pro Val Thr 
        275                 280                 285             


Ser Pro Ala Ala Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly 
    290                 295                 300                 


Ser Ile Asp Asn Ile Arg His Gln Pro Gly Gly Gly Lys Val Gln Ile 
305                 310                 315                 320 


Val His Lys Lys Ile Asp Leu Ser Ser Val Gln Ser Lys Cys Gly Ser 
                325                 330                 335     


Lys Asp Asn Leu Lys His Met Pro Gly Gly Gly Thr Ile Gln Ile Thr 
            340                 345                 350         


His Lys Pro Ile Asp Leu Thr His Ile Thr Ser Lys Cys Gly Ser Phe 
        355                 360                 365             


Gly Asn Ile His His Arg Pro Gly Gly Gly Asn Val Glu Val Lys Ser 
    370                 375                 380                 


Glu Lys Leu Glu Phe Asp Lys Ile Gln Ser Lys Ile Gly Ser Leu Asp 
385                 390                 395                 400 


Asn Ile Thr His Thr Pro Gly Gly Gly Ala Lys Lys Ile Glu Ser His 
                405                 410                 415     


Lys Leu Met Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
            420                 425                 430         


Glu Ile Val Tyr Lys Ser Pro Gly Gln Ser Gly Glu Thr Ser Pro Arg 
        435                 440                 445             


Arg Leu Ser Asn Val Ser Ser Ser Gly Ser Ile Asn Met Thr Asp Ser 
    450                 455                 460                 


Pro Gln Leu Ser Thr Leu Ala Asp Gln Val Ser Ala Ser Leu Ala Lys 
465                 470                 475                 480 


Gln Gly Leu 
            


<210>  25
<211>  324
<212>  PRT
<213>  Xenopus tropicalis

<400>  25

Met Trp Ala Lys Gln Arg Thr Pro Arg Met Val Ser Lys Ser Lys Asp 
1               5                   10                  15      


Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly Ala Asp Gly Lys Thr 
            20                  25                  30          


Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly Gln 
        35                  40                  45              


Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys Thr 
    50                  55                  60                  


Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr 
65                  70                  75                  80  


Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro 
                85                  90                  95      


Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val Val 
            100                 105                 110         


Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln Thr 
        115                 120                 125             


Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly 
    130                 135                 140                 


Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile 
145                 150                 155                 160 


Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly Ser 
                165                 170                 175     


Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile Val 
            180                 185                 190         


Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser Leu 
        195                 200                 205             


Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser 
    210                 215                 220                 


Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser Leu 
225                 230                 235                 240 


Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr 
                245                 250                 255     


His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly 
            260                 265                 270         


Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser Pro 
        275                 280                 285             


Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val Asp 
    290                 295                 300                 


Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala 
305                 310                 315                 320 


Lys Gln Gly Leu 
                


<210>  26
<211>  483
<212>  PRT
<213>  Oryzias latipes

<400>  26

Met Asp Phe Met Asn Asn Ala Ser Asn Ser Tyr Gly Ser Gly Asp Thr 
1               5                   10                  15      


Met Ser Ser Ser Leu Ala Asn Met Thr Ile Asn Asp Gln His His Gln 
            20                  25                  30          


Glu Asn Gly Val Gln Met Gly His Arg Asn Ala Gly Asp Ala Lys Met 
        35                  40                  45              


Lys Glu Glu Glu Ala Ala Leu Ser Glu Asn Gly Leu Lys Ser Val Ser 
    50                  55                  60                  


Glu Leu Cys Gln Pro Glu Ser Ser His Cys Asp Asp Glu Ala Pro Pro 
65                  70                  75                  80  


Ala Glu Ser Ser Pro Ala Glu Lys Glu Glu Ala Glu Val Ser Gln Leu 
                85                  90                  95      


Ser Glu Asn Glu Ser Ile Thr Ser Glu Glu Lys Gly Gln Pro Ala Ala 
            100                 105                 110         


Gly Gly Ala Val Ser Thr Ala Gln Gly Lys Thr Glu Asn Glu Val Lys 
        115                 120                 125             


Ser Pro Gly Gly Ala Lys Pro Gln Val Arg Gly Ala Lys Pro Pro Thr 
    130                 135                 140                 


Lys Thr Ala Ala Pro Asp Ala Arg Ser Gly Gln Ser Ser Pro Gly Thr 
145                 150                 155                 160 


Pro Lys Ser Pro Ala Ser Gln Ala Leu Ser Ala Ala Glu Ala Asn Lys 
                165                 170                 175     


Val Lys Lys Val Ala Val Val Arg Ser Thr Ser Lys Ser Pro Ala Ser 
            180                 185                 190         


Leu Lys Ser Arg Ser Pro Ala Pro Leu Ala Ala Ala Ala Pro Met Pro 
        195                 200                 205             


Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser Thr Glu Asn Ile Lys 
    210                 215                 220                 


His Gln Pro Gly Gly Gly Lys Val Gln Ile Leu Glu Gln Lys Leu Asp 
225                 230                 235                 240 


Leu Ser Asn Val Gln Ala Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
                245                 250                 255     


Gln Pro Gly Gly Gly Lys Val Gln Ile Leu Asp Lys Lys Leu Asp Leu 
            260                 265                 270         


Ser Ser Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys His Thr 
        275                 280                 285             


Pro Gly Gly Gly Lys Val Lys Ile Leu Glu Gln Arg Leu Asp Phe Ser 
    290                 295                 300                 


Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro 
305                 310                 315                 320 


Gly Gly Gly Asn Val Gln Ile Tyr Glu Lys Lys Leu Asp Leu Ser Ser 
                325                 330                 335     


Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Leu Gly His Val Pro Gly 
            340                 345                 350         


Gly Gly Asn Val Gln Ile Val His Lys Lys Ile Asp Leu Ser Thr Val 
        355                 360                 365             


Thr Ser Lys Cys Gly Ser Lys Ala Asn Ile His His Lys Pro Gly Gly 
    370                 375                 380                 


Gly Asn Ile Glu Ile Lys Ser Glu Lys Leu Glu Phe Lys Val Gln Ser 
385                 390                 395                 400 


Lys Ile Gly Ser Leu Asp Asn Ile Lys His Val Pro Gly Gly Gly Ala 
                405                 410                 415     


Lys Arg Ile Glu Ser His Lys Leu Thr Phe Arg Glu Thr Ala Lys Ala 
            420                 425                 430         


Arg Thr Asp His Gly Ala Glu Ile Val Ser Leu Glu Asp Ser Pro His 
        435                 440                 445             


Gln Leu Ser Thr Val Ser Ser Ser Gly Ser Ile Asn Met Ala Asp Ser 
    450                 455                 460                 


Pro Gln Leu Ser Thr Leu Ala Asp Gln Val Ser Ala Ser Leu Ala Lys 
465                 470                 475                 480 


Gln Gly Leu 
            


<210>  27
<211>  486
<212>  PRT
<213>  Oryzias latipes

<400>  27

Met Asp Phe Met Asn Asn Ala Ser Asn Ser Tyr Gly Ser Gly Asp Thr 
1               5                   10                  15      


Met Ser Ser Ser Leu Ala Asn Met Thr Ile Asn Asp Gln His His Gln 
            20                  25                  30          


Glu Asn Gly Val Gln Met Gly His Arg Asn Ala Gly Asp Ala Lys Met 
        35                  40                  45              


Lys Glu Glu Glu Ala Ala Leu Ser Glu Asn Gly Leu Lys Ser Val Ser 
    50                  55                  60                  


Glu Leu Cys Gln Pro Glu Ser Ser His Cys Asp Asp Glu Ala Pro Pro 
65                  70                  75                  80  


Ala Gln Gly Lys Thr Glu Asn Glu Val Lys Thr Gln Thr Ala Thr Ser 
                85                  90                  95      


Pro Val Ser Ser Pro Lys Arg Pro Ser Val Val Thr Thr Ala Ser Thr 
            100                 105                 110         


Arg Asn Gly His Ser Ser Ile Pro Val Lys Thr Ser Arg Ser Gly Pro 
        115                 120                 125             


Gly His Ala Ser Pro Gly Gly Ala Lys Pro Gln Val Arg Gly Ala Lys 
    130                 135                 140                 


Pro Pro Thr Lys Thr Ala Ala Pro Asp Ala Arg Ser Gly Gln Ser Ser 
145                 150                 155                 160 


Pro Gly Thr Pro Lys Ser Pro Ala Ser Gln Ala Leu Ser Ala Ala Glu 
                165                 170                 175     


Ala Asn Lys Val Lys Lys Val Ala Val Val Arg Ser Thr Ser Lys Ser 
            180                 185                 190         


Pro Ala Ser Leu Lys Ser Arg Ser Pro Ala Pro Leu Ala Ala Ala Ala 
        195                 200                 205             


Pro Met Pro Asp Leu Lys Asn Val Arg Ser Lys Ile Gly Ser Thr Glu 
    210                 215                 220                 


Asn Ile Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Leu Glu Gln 
225                 230                 235                 240 


Lys Leu Asp Leu Ser Asn Val Gln Ala Lys Cys Gly Ser Lys Asp Asn 
                245                 250                 255     


Ile Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Leu Asp Lys Lys 
            260                 265                 270         


Leu Asp Leu Ser Ser Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile 
        275                 280                 285             


Lys His Thr Pro Gly Gly Gly Lys Val Lys Ile Leu Glu Gln Arg Leu 
    290                 295                 300                 


Asp Phe Ser Asn Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys 
305                 310                 315                 320 


His Val Pro Gly Gly Gly Asn Val Gln Ile Tyr Glu Lys Lys Leu Asp 
                325                 330                 335     


Leu Ser Ser Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Leu Gly His 
            340                 345                 350         


Val Pro Gly Gly Gly Asn Val Gln Ile Val His Lys Lys Ile Asp Leu 
        355                 360                 365             


Ser Thr Val Thr Ser Lys Cys Gly Ser Lys Ala Asn Ile His His Lys 
    370                 375                 380                 


Pro Gly Gly Gly Asn Ile Glu Ile Lys Ser Glu Lys Leu Glu Phe Lys 
385                 390                 395                 400 


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Lys His Val Pro Gly 
                405                 410                 415     


Gly Gly Ala Lys Arg Ile Glu Ser His Lys Leu Thr Phe Arg Glu Thr 
            420                 425                 430         


Ala Lys Ala Arg Thr Asp His Gly Ala Glu Ile Val Ser Leu Glu Asp 
        435                 440                 445             


Ser Pro His Gln Leu Ser Thr Val Ser Ser Ser Gly Ser Ile Asn Met 
    450                 455                 460                 


Ala Asp Ser Pro Gln Leu Ser Thr Leu Ala Asp Gln Val Ser Ala Ser 
465                 470                 475                 480 


Leu Ala Lys Gln Gly Leu 
                485     


<210>  28
<211>  523
<212>  PRT
<213>  Oryzias latipes

<400>  28

Met Asp Phe Met Asn Asn Ala Ser Asn Ser Tyr Gly Ser Gly Asp Thr 
1               5                   10                  15      


Met Ser Ser Ser Leu Ala Asn Met Thr Ile Asn Asp Gln His His Gln 
            20                  25                  30          


Glu Asn Gly Val Gln Met Gly His Arg Asn Ala Gly Asp Ala Lys Met 
        35                  40                  45              


Lys Glu Glu Glu Ala Ala Leu Ser Glu Asn Gly Leu Lys Ser Val Ser 
    50                  55                  60                  


Glu Leu Cys Gln Pro Glu Ser Ser His Cys Asp Asp Glu Ala Pro Pro 
65                  70                  75                  80  


Ala Glu Ser Ser Pro Ala Glu Lys Glu Glu Ala Glu Val Ser Gln Leu 
                85                  90                  95      


Ser Glu Asn Glu Ser Ile Thr Ser Glu Glu Lys Gly Gln Pro Ala Gly 
            100                 105                 110         


Gly Ala Val Ser Thr Ala Gln Gly Lys Thr Glu Asn Glu Val Lys Thr 
        115                 120                 125             


Gln Thr Ala Thr Ser Pro Val Ser Ser Pro Lys Arg Pro Ser Val Val 
    130                 135                 140                 


Thr Thr Ala Ser Thr Arg Asn Gly His Ser Ser Ile Pro Val Lys Thr 
145                 150                 155                 160 


Ser Arg Ser Gly Pro Gly His Ala Ser Pro Gly Gly Ala Lys Pro Gln 
                165                 170                 175     


Val Arg Gly Ala Lys Pro Pro Thr Lys Thr Ala Ala Pro Asp Ala Arg 
            180                 185                 190         


Ser Gly Gln Ser Ser Pro Gly Thr Pro Lys Ser Pro Ala Ser Gln Ala 
        195                 200                 205             


Leu Ser Ala Ala Glu Ala Asn Lys Val Lys Lys Val Ala Val Val Arg 
    210                 215                 220                 


Ser Thr Ser Lys Ser Pro Ala Ser Leu Lys Ser Arg Ser Pro Ala Pro 
225                 230                 235                 240 


Leu Ala Ala Ala Ala Pro Met Pro Asp Leu Lys Asn Val Arg Ser Lys 
                245                 250                 255     


Ile Gly Ser Thr Glu Asn Ile Lys His Gln Pro Gly Gly Gly Lys Val 
            260                 265                 270         


Gln Ile Leu Glu Gln Lys Leu Asp Leu Ser Asn Val Gln Ala Lys Cys 
        275                 280                 285             


Gly Ser Lys Asp Asn Ile Lys His Gln Pro Gly Gly Gly Lys Val Gln 
    290                 295                 300                 


Ile Leu Asp Lys Lys Leu Asp Leu Ser Ser Val Gln Ser Arg Cys Gly 
305                 310                 315                 320 


Ser Lys Asp Asn Ile Lys His Thr Pro Gly Gly Gly Lys Val Lys Ile 
                325                 330                 335     


Leu Glu Gln Arg Leu Asp Phe Ser Asn Val Gln Ser Lys Cys Gly Ser 
            340                 345                 350         


Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Asn Val Gln Ile Tyr 
        355                 360                 365             


Glu Lys Lys Leu Asp Leu Ser Ser Val Gln Ser Arg Cys Gly Ser Lys 
    370                 375                 380                 


Asp Asn Leu Gly His Val Pro Gly Gly Gly Asn Val Gln Ile Val His 
385                 390                 395                 400 


Lys Lys Ile Asp Leu Ser Thr Val Thr Ser Lys Cys Gly Ser Lys Ala 
                405                 410                 415     


Asn Ile His His Lys Pro Gly Gly Gly Asn Ile Glu Ile Lys Ser Glu 
            420                 425                 430         


Lys Leu Glu Phe Lys Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile 
        435                 440                 445             


Lys His Val Pro Gly Gly Gly Ala Lys Arg Ile Glu Ser His Lys Leu 
    450                 455                 460                 


Thr Phe Arg Glu Thr Ala Lys Ala Arg Thr Asp His Gly Ala Glu Ile 
465                 470                 475                 480 


Val Ser Leu Glu Asp Ser Pro His Gln Leu Ser Thr Val Ser Ser Ser 
                485                 490                 495     


Gly Ser Ile Asn Met Ala Asp Ser Pro Gln Leu Ser Thr Leu Ala Asp 
            500                 505                 510         


Gln Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        515                 520             


<210>  29
<211>  524
<212>  PRT
<213>  Oryzias latipes

<400>  29

Met Asp Phe Met Asn Asn Ala Ser Asn Ser Tyr Gly Ser Gly Asp Thr 
1               5                   10                  15      


Met Ser Ser Ser Leu Ala Asn Met Thr Ile Asn Asp Gln His His Gln 
            20                  25                  30          


Glu Asn Gly Val Gln Met Gly His Arg Asn Ala Gly Asp Ala Lys Met 
        35                  40                  45              


Lys Glu Glu Glu Ala Ala Leu Ser Glu Asn Gly Leu Lys Ser Val Ser 
    50                  55                  60                  


Glu Leu Cys Gln Pro Glu Ser Ser His Cys Asp Asp Glu Ala Pro Pro 
65                  70                  75                  80  


Ala Glu Ser Ser Pro Ala Glu Lys Glu Glu Ala Glu Val Ser Gln Leu 
                85                  90                  95      


Ser Glu Asn Glu Ser Ile Thr Ser Glu Glu Lys Gly Gln Pro Ala Ala 
            100                 105                 110         


Gly Gly Ala Val Ser Thr Ala Gln Gly Lys Thr Glu Asn Glu Val Lys 
        115                 120                 125             


Thr Gln Thr Ala Thr Ser Pro Val Ser Ser Pro Lys Arg Pro Ser Val 
    130                 135                 140                 


Val Thr Thr Ala Ser Thr Arg Asn Gly His Ser Ser Ile Pro Val Lys 
145                 150                 155                 160 


Thr Ser Arg Ser Gly Pro Gly His Ala Ser Pro Gly Gly Ala Lys Pro 
                165                 170                 175     


Gln Val Arg Gly Ala Lys Pro Pro Thr Lys Thr Ala Ala Pro Asp Ala 
            180                 185                 190         


Arg Ser Gly Gln Ser Ser Pro Gly Thr Pro Lys Ser Pro Ala Ser Gln 
        195                 200                 205             


Ala Leu Ser Ala Ala Glu Ala Asn Lys Val Lys Lys Val Ala Val Val 
    210                 215                 220                 


Arg Ser Thr Ser Lys Ser Pro Ala Ser Leu Lys Ser Arg Ser Pro Ala 
225                 230                 235                 240 


Pro Leu Ala Ala Ala Ala Pro Met Pro Asp Leu Lys Asn Val Arg Ser 
                245                 250                 255     


Lys Ile Gly Ser Thr Glu Asn Ile Lys His Gln Pro Gly Gly Gly Lys 
            260                 265                 270         


Val Gln Ile Leu Glu Gln Lys Leu Asp Leu Ser Asn Val Gln Ala Lys 
        275                 280                 285             


Cys Gly Ser Lys Asp Asn Ile Lys His Gln Pro Gly Gly Gly Lys Val 
    290                 295                 300                 


Gln Ile Leu Asp Lys Lys Leu Asp Leu Ser Ser Val Gln Ser Arg Cys 
305                 310                 315                 320 


Gly Ser Lys Asp Asn Ile Lys His Thr Pro Gly Gly Gly Lys Val Lys 
                325                 330                 335     


Ile Leu Glu Gln Arg Leu Asp Phe Ser Asn Val Gln Ser Lys Cys Gly 
            340                 345                 350         


Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Asn Val Gln Ile 
        355                 360                 365             


Tyr Glu Lys Lys Leu Asp Leu Ser Ser Val Gln Ser Arg Cys Gly Ser 
    370                 375                 380                 


Lys Asp Asn Leu Gly His Val Pro Gly Gly Gly Asn Val Gln Ile Val 
385                 390                 395                 400 


His Lys Lys Ile Asp Leu Ser Thr Val Thr Ser Lys Cys Gly Ser Lys 
                405                 410                 415     


Ala Asn Ile His His Lys Pro Gly Gly Gly Asn Ile Glu Ile Lys Ser 
            420                 425                 430         


Glu Lys Leu Glu Phe Lys Val Gln Ser Lys Ile Gly Ser Leu Asp Asn 
        435                 440                 445             


Ile Lys His Val Pro Gly Gly Gly Ala Lys Arg Ile Glu Ser His Lys 
    450                 455                 460                 


Leu Thr Phe Arg Glu Thr Ala Lys Ala Arg Thr Asp His Gly Ala Glu 
465                 470                 475                 480 


Ile Val Ser Leu Glu Asp Ser Pro His Gln Leu Ser Thr Val Ser Ser 
                485                 490                 495     


Ser Gly Ser Ile Asn Met Ala Asp Ser Pro Gln Leu Ser Thr Leu Ala 
            500                 505                 510         


Asp Gln Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        515                 520                 


<210>  30
<211>  483
<212>  PRT
<213>  Notothenia coriiceps

<400>  30

Met Asp Tyr Thr Asn Asn Ser Ser Asn Ser Tyr Thr Ser Gly Asp Thr 
1               5                   10                  15      


Met Ser Ser Ser Leu Ala Asn Ile Thr Ile Ser Asp Gln His His Gln 
            20                  25                  30          


Glu Asn Gly Ile Met Lys Glu Pro Glu Ala Ala Val Ser Glu Asn Glu 
        35                  40                  45              


Ala Gln Pro Val Ser Glu Leu Cys Asp Asp Lys Val His Pro Val Glu 
    50                  55                  60                  


Thr Ser Glu Lys Ala Gly Val Glu Ala Ala Gly Ser Glu Leu Ser Glu 
65                  70                  75                  80  


Thr Glu Ser Thr Ser Cys Gly Gly Glu Gly Gln Leu Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Gly Gly Gly Gly Ala Ala Ser Thr Ala Gln Ala Lys Ile Asp 
            100                 105                 110         


Asn Ala Ser Ala Asp Lys Gly Pro Gly Leu Ala Lys Ser Gln Thr Gln 
        115                 120                 125             


Gly Val Lys Ser Ala Ala Gln Ala Ala Ser Ala Lys Lys Pro Pro Thr 
    130                 135                 140                 


Pro Lys Asn Gln Lys Asp Gly Ser Gly His Ser Ser Pro Gly Thr Lys 
145                 150                 155                 160 


Ser Pro Ser Ser Gln Leu Ser Ala Lys Ala Ala Ala Glu Ala Asn Lys 
                165                 170                 175     


Val Lys Lys Val Ala Val Val Arg Ser Thr Pro Lys Ser Pro Gly Ser 
            180                 185                 190         


Leu Lys Ser Arg Pro Pro Val Pro Leu Ala Ala Ala Ala Pro Met Pro 
        195                 200                 205             


Asp Leu Lys Asn Val Arg Ser Lys Val Gly Ser Thr Asp Asn Leu Lys 
    210                 215                 220                 


His Gln Pro Gly Gly Gly Lys Val Gln Ile Leu Glu Gln Lys Leu Asp 
225                 230                 235                 240 


Phe Ser Ser Val Gln Ser Lys Cys Gly Ser Lys Gly Asn Met Lys His 
                245                 250                 255     


Val Pro Gly Gly Gly Asn Val Gln Ile Leu Asp Lys Lys Leu Glu Leu 
            260                 265                 270         


Pro Asn Val Ser Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys His Thr 
        275                 280                 285             


Pro Gly Gly Gly Lys Val Gln Ile Val Glu Lys Lys Leu Asp Leu Ser 
    290                 295                 300                 


Ser Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Met Lys His Val Ala 
305                 310                 315                 320 


Gly Gly Gly Asn Val Gln Ile Val Glu Lys Lys Leu Asp Leu Ser Ser 
                325                 330                 335     


Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys His Val Ala Gly 
            340                 345                 350         


Gly Gly Asn Val Gln Ile Val His Lys Lys Val Asp Leu Thr Asn Val 
        355                 360                 365             


Gln Ala Lys Cys Gly Ser Lys Ser Asn Leu His His Lys Pro Gly Gly 
    370                 375                 380                 


Gly Asn Ile Glu Ile Lys Asn Glu Lys Val Glu Phe Lys Gly Gln Ser 
385                 390                 395                 400 


Lys Val Gly Ser Leu Gly Asn Ile Gly His Val Pro Gly Gly Gly Gln 
                405                 410                 415     


Arg Arg Ile Glu Ser His Lys Leu Ser Phe Arg Glu Ser Ala Lys Ala 
            420                 425                 430         


Arg Thr Asp His Gly Ala Glu Ile Val Ser Leu Glu Asp Ser Pro His 
        435                 440                 445             


Pro Leu Ser Thr Val Ser Ser Ser Gly Ser Leu Asn Ile Ala Asp Ser 
    450                 455                 460                 


Pro Gln Leu Ser Thr Leu Ala Asp Gln Val Ser Ala Ser Leu Ala Lys 
465                 470                 475                 480 


Gln Gly Leu 
            


<210>  31
<211>  529
<212>  PRT
<213>  Notothenia coriiceps

<400>  31

Met Asp Tyr Thr Asn Asn Ser Ser Asn Ser Tyr Thr Ser Gly Asp Thr 
1               5                   10                  15      


Met Ser Ser Ser Leu Ala Asn Ile Thr Ile Ser Asp Gln His His Gln 
            20                  25                  30          


Glu Asn Gly Ile Met Lys Glu Pro Glu Ala Ala Val Ser Glu Asn Glu 
        35                  40                  45              


Ala Gln Pro Val Ser Glu Leu Cys Asp Asp Lys Val His Pro Val Glu 
    50                  55                  60                  


Thr Ser Glu Lys Ala Gly Val Glu Ala Ala Gly Ser Glu Leu Ser Glu 
65                  70                  75                  80  


Thr Glu Ser Thr Ser Cys Gly Gly Glu Gly Gln Leu Ala Ala Ala Ala 
                85                  90                  95      


Ala Gly Gly Gly Gly Ala Ala Ser Thr Ala Gln Ala Lys Ile Asp Asn 
            100                 105                 110         


Ala Ser Ala Asp Lys Thr Pro Thr Ala Ile Lys Pro Thr Ser Ser Pro 
        115                 120                 125             


Lys Arg Pro Ser Pro Val Thr Gly Gly Asn Lys Thr Asn Ser Pro Ser 
    130                 135                 140                 


Gly Asn Gly Pro Ser Ser Ile Pro Ile Lys Ser Ser Ser Pro Gly Pro 
145                 150                 155                 160 


Arg Gln Pro Gly Gly Pro Gly Leu Ala Lys Ser Gln Thr Gln Gly Val 
                165                 170                 175     


Lys Ser Ala Ala Gln Ala Ala Ser Ala Lys Lys Pro Pro Thr Pro Lys 
            180                 185                 190         


Asn Gln Lys Asp Gly Ser Gly His Ser Ser Pro Gly Thr Lys Ser Pro 
        195                 200                 205             


Ser Ser Gln Leu Ser Ala Lys Ala Ala Ala Glu Ala Asn Lys Val Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Ser Thr Pro Lys Ser Pro Gly Ser Leu Lys 
225                 230                 235                 240 


Ser Arg Pro Pro Val Pro Leu Ala Ala Ala Ala Pro Met Pro Asp Leu 
                245                 250                 255     


Lys Asn Val Arg Ser Lys Val Gly Ser Thr Asp Asn Leu Lys His Gln 
            260                 265                 270         


Pro Gly Gly Gly Lys Val Gln Ile Leu Glu Gln Lys Leu Asp Phe Ser 
        275                 280                 285             


Ser Val Gln Ser Lys Cys Gly Ser Lys Gly Asn Met Lys His Val Pro 
    290                 295                 300                 


Gly Gly Gly Asn Val Gln Ile Leu Asp Lys Lys Leu Glu Leu Pro Asn 
305                 310                 315                 320 


Val Ser Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys His Thr Pro Gly 
                325                 330                 335     


Gly Gly Lys Val Gln Ile Val Glu Lys Lys Leu Asp Leu Ser Ser Val 
            340                 345                 350         


Gln Ser Arg Cys Gly Ser Lys Asp Asn Met Lys His Val Ala Gly Gly 
        355                 360                 365             


Gly Asn Val Gln Ile Val Glu Lys Lys Leu Asp Leu Ser Ser Val Gln 
    370                 375                 380                 


Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys His Val Ala Gly Gly Gly 
385                 390                 395                 400 


Asn Val Gln Ile Val His Lys Lys Val Asp Leu Thr Asn Val Gln Ala 
                405                 410                 415     


Lys Cys Gly Ser Lys Ser Asn Leu His His Lys Pro Gly Gly Gly Asn 
            420                 425                 430         


Ile Glu Ile Lys Asn Glu Lys Val Glu Phe Lys Gly Gln Ser Lys Val 
        435                 440                 445             


Gly Ser Leu Gly Asn Ile Gly His Val Pro Gly Gly Gly Gln Arg Arg 
    450                 455                 460                 


Ile Glu Ser His Lys Leu Ser Phe Arg Glu Ser Ala Lys Ala Arg Thr 
465                 470                 475                 480 


Asp His Gly Ala Glu Ile Val Ser Leu Glu Asp Ser Pro His Pro Leu 
                485                 490                 495     


Ser Thr Val Ser Ser Ser Gly Ser Leu Asn Ile Ala Asp Ser Pro Gln 
            500                 505                 510         


Leu Ser Thr Leu Ala Asp Gln Val Ser Ala Ser Leu Ala Lys Gln Gly 
        515                 520                 525             


Leu 
    


<210>  32
<211>  530
<212>  PRT
<213>  Notothenia coriiceps

<400>  32

Met Asp Tyr Thr Asn Asn Ser Ser Asn Ser Tyr Thr Ser Gly Asp Thr 
1               5                   10                  15      


Met Ser Ser Ser Leu Ala Asn Ile Thr Ile Ser Asp Gln His His Gln 
            20                  25                  30          


Glu Asn Gly Ile Met Lys Glu Pro Glu Ala Ala Val Ser Glu Asn Glu 
        35                  40                  45              


Ala Gln Pro Val Ser Glu Leu Cys Asp Asp Lys Val His Pro Val Glu 
    50                  55                  60                  


Thr Ser Glu Lys Ala Gly Val Glu Ala Ala Gly Ser Glu Leu Ser Glu 
65                  70                  75                  80  


Thr Glu Ser Thr Ser Cys Gly Gly Glu Gly Gln Leu Ala Ala Ala Ala 
                85                  90                  95      


Ala Ala Gly Gly Gly Gly Ala Ala Ser Thr Ala Gln Ala Lys Ile Asp 
            100                 105                 110         


Asn Ala Ser Ala Asp Lys Thr Pro Thr Ala Ile Lys Pro Thr Ser Ser 
        115                 120                 125             


Pro Lys Arg Pro Ser Pro Val Thr Gly Gly Asn Lys Thr Asn Ser Pro 
    130                 135                 140                 


Ser Gly Asn Gly Pro Ser Ser Ile Pro Ile Lys Ser Ser Ser Pro Gly 
145                 150                 155                 160 


Pro Arg Gln Pro Gly Gly Pro Gly Leu Ala Lys Ser Gln Thr Gln Gly 
                165                 170                 175     


Val Lys Ser Ala Ala Gln Ala Ala Ser Ala Lys Lys Pro Pro Thr Pro 
            180                 185                 190         


Lys Asn Gln Lys Asp Gly Ser Gly His Ser Ser Pro Gly Thr Lys Ser 
        195                 200                 205             


Pro Ser Ser Gln Leu Ser Ala Lys Ala Ala Ala Glu Ala Asn Lys Val 
    210                 215                 220                 


Lys Lys Val Ala Val Val Arg Ser Thr Pro Lys Ser Pro Gly Ser Leu 
225                 230                 235                 240 


Lys Ser Arg Pro Pro Val Pro Leu Ala Ala Ala Ala Pro Met Pro Asp 
                245                 250                 255     


Leu Lys Asn Val Arg Ser Lys Val Gly Ser Thr Asp Asn Leu Lys His 
            260                 265                 270         


Gln Pro Gly Gly Gly Lys Val Gln Ile Leu Glu Gln Lys Leu Asp Phe 
        275                 280                 285             


Ser Ser Val Gln Ser Lys Cys Gly Ser Lys Gly Asn Met Lys His Val 
    290                 295                 300                 


Pro Gly Gly Gly Asn Val Gln Ile Leu Asp Lys Lys Leu Glu Leu Pro 
305                 310                 315                 320 


Asn Val Ser Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys His Thr Pro 
                325                 330                 335     


Gly Gly Gly Lys Val Gln Ile Val Glu Lys Lys Leu Asp Leu Ser Ser 
            340                 345                 350         


Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Met Lys His Val Ala Gly 
        355                 360                 365             


Gly Gly Asn Val Gln Ile Val Glu Lys Lys Leu Asp Leu Ser Ser Val 
    370                 375                 380                 


Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys His Val Ala Gly Gly 
385                 390                 395                 400 


Gly Asn Val Gln Ile Val His Lys Lys Val Asp Leu Thr Asn Val Gln 
                405                 410                 415     


Ala Lys Cys Gly Ser Lys Ser Asn Leu His His Lys Pro Gly Gly Gly 
            420                 425                 430         


Asn Ile Glu Ile Lys Asn Glu Lys Val Glu Phe Lys Gly Gln Ser Lys 
        435                 440                 445             


Val Gly Ser Leu Gly Asn Ile Gly His Val Pro Gly Gly Gly Gln Arg 
    450                 455                 460                 


Arg Ile Glu Ser His Lys Leu Ser Phe Arg Glu Ser Ala Lys Ala Arg 
465                 470                 475                 480 


Thr Asp His Gly Ala Glu Ile Val Ser Leu Glu Asp Ser Pro His Pro 
                485                 490                 495     


Leu Ser Thr Val Ser Ser Ser Gly Ser Leu Asn Ile Ala Asp Ser Pro 
            500                 505                 510         


Gln Leu Ser Thr Leu Ala Asp Gln Val Ser Ala Ser Leu Ala Lys Gln 
        515                 520                 525             


Gly Leu 
    530 


<210>  33
<211>  432
<212>  PRT
<213>  Gallus gallus

<400>  33

Met Ala Glu Pro His Gln Asp Ile Thr Thr Val Glu Glu Gln Glu Arg 
1               5                   10                  15      


Gln His Val Pro Ser Gly Tyr Pro Leu Gln Ile Pro Val Asp Asp Gly 
            20                  25                  30          


Ser Asp Glu Pro Val Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr 
        35                  40                  45              


Thr Glu Asp Ala Thr Ala Pro Leu Val Glu Glu Gly Asp Gln Glu Asp 
    50                  55                  60                  


Gln His Gly Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile 
65                  70                  75                  80  


Gly Ala Thr Pro Ser Leu Glu Asp His Ala Ala Gly Asp Ala Ala Gln 
                85                  90                  95      


Ala Arg Ile Asp Ser Lys Asp Lys Glu Gly Ala Glu Thr Asp Glu Lys 
            100                 105                 110         


Lys Pro Lys Gly Gln Glu Met Arg Gly Gly Thr Lys Pro Ala Thr Pro 
        115                 120                 125             


Arg Ser Ala Ala Gly Gln Ala Gln Arg Asn Ser Ser Asn Ala Thr Arg 
    130                 135                 140                 


Ile Pro Ala Lys Thr Pro Thr Ala Pro Lys Thr Pro Pro Gly Ser Gly 
145                 150                 155                 160 


Arg Lys Glu Gln Lys Lys Pro Pro Pro Ala Ala Ala Lys Pro Glu Lys 
                165                 170                 175     


Gly Glu Gln Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
            180                 185                 190         


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
        195                 200                 205             


Pro Pro Ala Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
    210                 215                 220                 


Lys Ser Pro Ala Ser Ala Lys Ser Arg Val Gln Pro Ser Ala Ala Pro 
225                 230                 235                 240 


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn 
                245                 250                 255     


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys 
            260                 265                 270         


Leu Asp Phe Ser Ser Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile 
        275                 280                 285             


Lys His Ile Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val 
    290                 295                 300                 


Asp Leu Ser His Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
305                 310                 315                 320 


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
                325                 330                 335     


Phe Lys Asp Lys Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Ser 
            340                 345                 350         


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
        355                 360                 365             


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
    370                 375                 380                 


Tyr Lys Ser Pro Thr Ile Ser Gly Asp Ala Ser Pro Arg Arg Leu Ser 
385                 390                 395                 400 


Asn Val Ser Ser Thr Gly Ser Ile Asn Met Val Asp Ser Pro Gln Leu 
                405                 410                 415     


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            420                 425                 430         


<210>  34
<211>  345
<212>  PRT
<213>  Gallus gallus

<400>  34

Met Ala Glu Pro His Gln Asp Ile Thr Thr Val Glu Glu Gln Glu Arg 
1               5                   10                  15      


Gln His Val Pro Ser Ala Glu Glu Ala Gly Ile Gly Ala Thr Pro Ser 
            20                  25                  30          


Leu Glu Asp His Ala Ala Gly Asp Ala Ala Gln Ala Arg Ile Asp Ser 
        35                  40                  45              


Lys Asp Lys Glu Gly Ala Glu Thr Asp Glu Lys Lys Pro Lys Gly Gln 
    50                  55                  60                  


Glu Met Arg Gly Gly Thr Lys Pro Ala Thr Pro Arg Ser Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Gln Arg Asn Ser Ser Asn Ala Thr Arg Ile Pro Ala Lys Thr 
                85                  90                  95      


Pro Thr Ala Pro Lys Thr Pro Pro Gly Ser Gly Arg Lys Glu Gln Lys 
            100                 105                 110         


Lys Pro Pro Pro Ala Ala Ala Lys Pro Glu Lys Ala Arg Glu Pro Lys 
        115                 120                 125             


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ala Ser Ala Lys 
    130                 135                 140                 


Ser Arg Val Gln Pro Ser Ala Ala Pro Met Pro Asp Leu Lys Asn Val 
145                 150                 155                 160 


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
                165                 170                 175     


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Phe Ser Ser Val Gln 
            180                 185                 190         


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Ile Pro Gly Gly Gly 
        195                 200                 205             


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser His Val Thr Ser 
    210                 215                 220                 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
225                 230                 235                 240 


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Lys Val Gln Ser 
                245                 250                 255     


Lys Ile Gly Ser Leu Asp Asn Ile Ser His Val Pro Gly Gly Gly Asn 
            260                 265                 270         


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
        275                 280                 285             


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Thr Ile Ser 
    290                 295                 300                 


Gly Asp Ala Ser Pro Arg Arg Leu Ser Asn Val Ser Ser Thr Gly Ser 
305                 310                 315                 320 


Ile Asn Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
                325                 330                 335     


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            340                 345 


<210>  35
<211>  348
<212>  PRT
<213>  Gallus gallus

<400>  35

Met Ala Glu Pro His Gln Asp Ile Thr Thr Val Glu Glu Gln Glu Arg 
1               5                   10                  15      


Gln His Val Pro Ser Ala Glu Glu Ala Gly Ile Gly Ala Thr Pro Ser 
            20                  25                  30          


Leu Glu Asp His Ala Ala Gly Asp Ala Ala Gln Ala Arg Ile Asp Ser 
        35                  40                  45              


Lys Asp Lys Glu Gly Ala Glu Thr Asp Glu Lys Lys Pro Lys Gly Gln 
    50                  55                  60                  


Glu Met Arg Gly Gly Thr Lys Pro Ala Thr Pro Arg Ser Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Gln Arg Asn Ser Ser Asn Ala Thr Arg Ile Pro Ala Lys Thr 
                85                  90                  95      


Pro Thr Ala Pro Lys Thr Pro Pro Gly Ser Gly Arg Lys Glu Gln Lys 
            100                 105                 110         


Lys Pro Pro Pro Ala Ala Ala Lys Pro Glu Lys Gly Glu Gln Pro Lys 
        115                 120                 125             


Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro 
    130                 135                 140                 


Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Ala Arg Glu 
145                 150                 155                 160 


Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ala Ser 
                165                 170                 175     


Ala Lys Ser Arg Val Gln Pro Ser Ala Ala Pro Met Pro Asp Leu Lys 
            180                 185                 190         


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        195                 200                 205             


Gly Gly Gly Lys Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser His 
    210                 215                 220                 


Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly 
225                 230                 235                 240 


Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Lys 
                245                 250                 255     


Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Ser His Val Pro Gly 
            260                 265                 270         


Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn 
        275                 280                 285             


Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro 
    290                 295                 300                 


Thr Ile Ser Gly Asp Ala Ser Pro Arg Arg Leu Ser Asn Val Ser Ser 
305                 310                 315                 320 


Thr Gly Ser Ile Asn Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala 
                325                 330                 335     


Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            340                 345             


<210>  36
<211>  400
<212>  PRT
<213>  Gallus gallus

<400>  36

Met Ala Glu Pro His Gln Asp Ile Thr Thr Val Glu Glu Gln Glu Arg 
1               5                   10                  15      


Gln His Val Pro Ser Asp Ala Thr Ala Pro Leu Val Glu Glu Gly Asp 
            20                  25                  30          


Gln Glu Asp Gln His Gly Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu 
        35                  40                  45              


Ala Gly Ile Gly Ala Thr Pro Ser Leu Glu Asp His Ala Ala Gly Asp 
    50                  55                  60                  


Ala Ala Gln Ala Arg Ile Asp Ser Lys Asp Lys Glu Gly Ala Glu Thr 
65                  70                  75                  80  


Asp Glu Lys Lys Pro Lys Gly Gln Glu Met Arg Gly Gly Thr Lys Pro 
                85                  90                  95      


Ala Thr Pro Arg Ser Ala Ala Gly Gln Ala Gln Arg Asn Ser Ser Asn 
            100                 105                 110         


Ala Thr Arg Ile Pro Ala Lys Thr Pro Thr Ala Pro Lys Thr Pro Pro 
        115                 120                 125             


Gly Ser Gly Arg Lys Glu Gln Lys Lys Pro Pro Pro Ala Ala Ala Lys 
    130                 135                 140                 


Pro Glu Lys Ala Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro 
145                 150                 155                 160 


Pro Lys Ser Pro Ala Ser Ala Lys Ser Arg Val Gln Pro Ser Ala Ala 
                165                 170                 175     


Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu 
            180                 185                 190         


Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys 
        195                 200                 205             


Lys Leu Asp Phe Ser Ser Val Gln Ser Lys Cys Gly Ser Lys Asp Asn 
    210                 215                 220                 


Ile Lys His Ile Pro Gly Gly Gly Ser Val Gln Ile Val Asn Gln Lys 
225                 230                 235                 240 


Leu Asp Phe Ser Ser Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile 
                245                 250                 255     


Lys His Ile Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val 
            260                 265                 270         


Asp Leu Ser His Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His 
        275                 280                 285             


His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp 
    290                 295                 300                 


Phe Lys Asp Lys Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Ser 
305                 310                 315                 320 


His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr 
                325                 330                 335     


Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val 
            340                 345                 350         


Tyr Lys Ser Pro Thr Ile Ser Gly Asp Ala Ser Pro Arg Arg Leu Ser 
        355                 360                 365             


Asn Val Ser Ser Thr Gly Ser Ile Asn Met Val Asp Ser Pro Gln Leu 
    370                 375                 380                 


Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
385                 390                 395                 400 


<210>  37
<211>  410
<212>  PRT
<213>  Gallus gallus

<400>  37

Met Ala Glu Pro His Gln Asp Ile Thr Thr Val Glu Glu Gln Glu Arg 
1               5                   10                  15      


Gln His Val Pro Ser Ala Glu Glu Ala Gly Ile Gly Ala Thr Pro Ser 
            20                  25                  30          


Leu Glu Asp His Ala Ala Gly Asp Ala Ala Gln Ala Arg Ile Asp Ser 
        35                  40                  45              


Lys Asp Lys Glu Gly Ala Glu Thr Asp Glu Lys Lys Pro Lys Gly Gln 
    50                  55                  60                  


Glu Met Arg Gly Gly Thr Lys Pro Ala Thr Pro Arg Ser Ala Ala Gly 
65                  70                  75                  80  


Gln Ala Gln Arg Asn Ser Ser Asn Ala Thr Arg Ile Pro Ala Lys Thr 
                85                  90                  95      


Pro Thr Ala Pro Lys Thr Pro Pro Gly Ser Gly Arg Lys Glu Gln Lys 
            100                 105                 110         


Lys Pro Pro Pro Ala Ala Ala Lys Pro Glu Lys Gly Glu Gln Pro Lys 
        115                 120                 125             


Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro 
    130                 135                 140                 


Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Ala Arg Glu 
145                 150                 155                 160 


Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ala Ser 
                165                 170                 175     


Ala Lys Ser Arg Val Gln Pro Ser Ala Ala Pro Met Pro Asp Leu Lys 
            180                 185                 190         


Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro 
        195                 200                 205             


Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Phe Ser Ser 
    210                 215                 220                 


Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Ile Pro Gly 
225                 230                 235                 240 


Gly Gly Ser Val Gln Ile Val Asn Gln Lys Leu Asp Phe Ser Ser Val 
                245                 250                 255     


Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys His Ile Pro Gly Gly 
            260                 265                 270         


Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser His Val Thr 
        275                 280                 285             


Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly 
    290                 295                 300                 


Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Lys Val Gln 
305                 310                 315                 320 


Ser Lys Ile Gly Ser Leu Asp Asn Ile Ser His Val Pro Gly Gly Gly 
                325                 330                 335     


Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys 
            340                 345                 350         


Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Thr Ile 
        355                 360                 365             


Ser Gly Asp Ala Ser Pro Arg Arg Leu Ser Asn Val Ser Ser Thr Gly 
    370                 375                 380                 


Ser Ile Asn Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu 
385                 390                 395                 400 


Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
                405                 410 


<210>  38
<211>  429
<212>  PRT
<213>  Gallus gallus

<400>  38

Met Ala Glu Pro His Gln Asp Ile Thr Thr Val Glu Glu Gln Glu Arg 
1               5                   10                  15      


Gln His Val Pro Ser Gly Tyr Pro Leu Gln Ile Pro Val Asp Asp Gly 
            20                  25                  30          


Ser Asp Glu Pro Val Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr 
        35                  40                  45              


Thr Glu Asp Ala Thr Ala Pro Leu Val Glu Glu Gly Asp Gln Glu Asp 
    50                  55                  60                  


Gln His Gly Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile 
65                  70                  75                  80  


Gly Ala Thr Pro Ser Leu Glu Asp His Ala Ala Gly Asp Ala Ala Gln 
                85                  90                  95      


Ala Arg Ile Asp Ser Lys Asp Lys Glu Gly Ala Glu Thr Asp Glu Lys 
            100                 105                 110         


Lys Pro Lys Gly Gln Glu Met Arg Gly Gly Thr Lys Pro Ala Thr Pro 
        115                 120                 125             


Arg Ser Ala Ala Gly Gln Ala Gln Arg Asn Ser Ser Asn Ala Thr Arg 
    130                 135                 140                 


Ile Pro Ala Lys Thr Pro Thr Ala Pro Lys Thr Pro Pro Gly Ser Gly 
145                 150                 155                 160 


Arg Lys Glu Gln Lys Lys Pro Pro Pro Ala Ala Ala Lys Pro Glu Lys 
                165                 170                 175     


Ala Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser 
            180                 185                 190         


Pro Ala Ser Ala Lys Ser Arg Val Gln Pro Ser Ala Ala Pro Met Pro 
        195                 200                 205             


Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys 
    210                 215                 220                 


His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp 
225                 230                 235                 240 


Phe Ser Ser Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His 
                245                 250                 255     


Ile Pro Gly Gly Gly Ser Val Gln Ile Val Asn Gln Lys Leu Asp Phe 
            260                 265                 270         


Ser Ser Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys His Ile 
        275                 280                 285             


Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser 
    290                 295                 300                 


His Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro 
305                 310                 315                 320 


Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp 
                325                 330                 335     


Lys Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Ser His Val Pro 
            340                 345                 350         


Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu 
        355                 360                 365             


Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser 
    370                 375                 380                 


Pro Thr Ile Ser Gly Asp Ala Ser Pro Arg Arg Leu Ser Asn Val Ser 
385                 390                 395                 400 


Ser Thr Gly Ser Ile Asn Met Val Asp Ser Pro Gln Leu Ala Thr Leu 
                405                 410                 415     


Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
            420                 425                 


<210>  39
<211>  463
<212>  PRT
<213>  Gallus gallus

<400>  39

Met Ala Glu Pro His Gln Asp Ile Thr Thr Val Glu Glu Gln Glu Arg 
1               5                   10                  15      


Gln His Val Pro Ser Gly Tyr Pro Leu Gln Ile Pro Val Asp Asp Gly 
            20                  25                  30          


Ser Asp Glu Pro Val Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr 
        35                  40                  45              


Thr Glu Asp Ala Thr Ala Pro Leu Val Glu Glu Gly Asp Gln Glu Asp 
    50                  55                  60                  


Gln His Gly Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile 
65                  70                  75                  80  


Gly Ala Thr Pro Ser Leu Glu Asp His Ala Ala Gly Asp Ala Ala Gln 
                85                  90                  95      


Ala Arg Ile Asp Ser Lys Asp Lys Glu Gly Ala Glu Thr Asp Glu Lys 
            100                 105                 110         


Lys Pro Lys Gly Gln Glu Met Arg Gly Gly Thr Lys Pro Ala Thr Pro 
        115                 120                 125             


Arg Ser Ala Ala Gly Gln Ala Gln Arg Asn Ser Ser Asn Ala Thr Arg 
    130                 135                 140                 


Ile Pro Ala Lys Thr Pro Thr Ala Pro Lys Thr Pro Pro Gly Ser Gly 
145                 150                 155                 160 


Arg Lys Glu Gln Lys Lys Pro Pro Pro Ala Ala Ala Lys Pro Glu Lys 
                165                 170                 175     


Gly Glu Gln Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
            180                 185                 190         


Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
        195                 200                 205             


Pro Pro Ala Arg Glu Pro Lys Lys Val Ala Val Val Arg Thr Pro Pro 
    210                 215                 220                 


Lys Ser Pro Ala Ser Ala Lys Ser Arg Val Gln Pro Ser Ala Ala Pro 
225                 230                 235                 240 


Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly Ser Thr Glu Asn 
                245                 250                 255     


Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile Ile Asn Lys Lys 
            260                 265                 270         


Leu Asp Phe Ser Ser Val Gln Ser Lys Cys Gly Ser Lys Asp Asn Ile 
        275                 280                 285             


Lys His Ile Pro Gly Gly Gly Ser Val Gln Ile Val Asn Gln Lys Leu 
    290                 295                 300                 


Asp Phe Ser Ser Val Gln Ser Arg Cys Gly Ser Lys Asp Asn Ile Lys 
305                 310                 315                 320 


His Ile Pro Gly Gly Gly Ser Val Gln Ile Val Tyr Lys Pro Val Asp 
                325                 330                 335     


Leu Ser His Val Thr Ser Lys Cys Gly Ser Leu Gly Asn Ile His His 
            340                 345                 350         


Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu Lys Leu Asp Phe 
        355                 360                 365             


Lys Asp Lys Val Gln Ser Lys Ile Gly Ser Leu Asp Asn Ile Ser His 
    370                 375                 380                 


Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His Lys Leu Thr Phe 
385                 390                 395                 400 


Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala Glu Ile Val Tyr 
                405                 410                 415     


Lys Ser Pro Thr Ile Ser Gly Asp Ala Ser Pro Arg Arg Leu Ser Asn 
            420                 425                 430         


Val Ser Ser Thr Gly Ser Ile Asn Met Val Asp Ser Pro Gln Leu Ala 
        435                 440                 445             


Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys Gln Gly Leu 
    450                 455                 460             


<210>  40
<211>  467
<212>  PRT
<213>  Gallus gallus

<400>  40

Met Ala Glu Pro His Gln Asp Ile Thr Thr Val Glu Glu Gln Glu Arg 
1               5                   10                  15      


Gln His Val Pro Ser Ala Glu Glu Ala Gly Ile Gly Ala Thr Pro Ser 
            20                  25                  30          


Leu Glu Asp His Ala Ala Gly Asp Ala Ala Gln Ala Arg Ile Asp Ser 
        35                  40                  45              


Lys Asp Lys Glu Gly Ala Glu Thr Asp Glu Lys Lys Pro Lys Lys Ser 
    50                  55                  60                  


Ser Pro Cys Thr Ala Lys Pro Pro Gly Asp Arg Ala Ser Ile Pro Pro 
65                  70                  75                  80  


His Arg His Thr Ser Ser Ser Thr Ala Pro Pro Lys Ser Pro Ser Ser 
                85                  90                  95      


Pro Ala Ser Thr Ser Lys Arg Val Thr Pro Arg Pro Ala Ser Thr Gly 
            100                 105                 110         


Thr His Glu Thr Lys Ala Lys Gly Gln Glu Met Arg Gly Gly Thr Lys 
        115                 120                 125             


Pro Ala Thr Pro Arg Ser Ala Ala Gly Gln Ala Gln Arg Asn Ser Ser 
    130                 135                 140                 


Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Thr Ala Pro Lys Thr Pro 
145                 150                 155                 160 


Pro Gly Ser Gly Arg Lys Glu Gln Lys Lys Pro Pro Pro Ala Ala Ala 
                165                 170                 175     


Lys Pro Glu Lys Gly Glu Gln Pro Lys Ser Gly Asp Arg Ser Gly Tyr 
            180                 185                 190         


Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr Pro 
        195                 200                 205             


Ser Leu Pro Thr Pro Pro Ala Arg Glu Pro Lys Lys Val Ala Val Val 
    210                 215                 220                 


Arg Thr Pro Pro Lys Ser Pro Ala Ser Ala Lys Ser Arg Val Gln Pro 
225                 230                 235                 240 


Ser Ala Ala Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile Gly 
                245                 250                 255     


Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln Ile 
            260                 265                 270         


Ile Asn Lys Lys Leu Asp Phe Ser Ser Val Gln Ser Lys Cys Gly Ser 
        275                 280                 285             


Lys Asp Asn Ile Lys His Ile Pro Gly Gly Gly Ser Val Gln Ile Val 
    290                 295                 300                 


Asn Gln Lys Leu Asp Phe Ser Ser Val Gln Ser Arg Cys Gly Ser Lys 
305                 310                 315                 320 


Asp Asn Ile Lys His Ile Pro Gly Gly Gly Ser Val Gln Ile Val Tyr 
                325                 330                 335     


Lys Pro Val Asp Leu Ser His Val Thr Ser Lys Cys Gly Ser Leu Gly 
            340                 345                 350         


Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys Ser Glu 
        355                 360                 365             


Lys Leu Asp Phe Lys Asp Lys Val Gln Ser Lys Ile Gly Ser Leu Asp 
    370                 375                 380                 


Asn Ile Ser His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu Thr His 
385                 390                 395                 400 


Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His Gly Ala 
                405                 410                 415     


Glu Ile Val Tyr Lys Ser Pro Thr Ile Ser Gly Asp Ala Ser Pro Arg 
            420                 425                 430         


Arg Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asn Met Val Asp Ser 
        435                 440                 445             


Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu Ala Lys 
    450                 455                 460                 


Gln Gly Leu 
465         


<210>  41
<211>  520
<212>  PRT
<213>  Gallus gallus

<400>  41

Met Ala Glu Pro His Gln Asp Ile Thr Thr Val Glu Glu Gln Glu Arg 
1               5                   10                  15      


Gln His Val Pro Ser Gly Tyr Pro Leu Gln Ile Pro Val Asp Asp Gly 
            20                  25                  30          


Ser Asp Glu Pro Val Ser Glu Thr Ser Asp Ala Lys Ser Thr Pro Thr 
        35                  40                  45              


Thr Glu Asp Ala Thr Ala Pro Leu Val Glu Glu Gly Asp Gln Glu Asp 
    50                  55                  60                  


Gln His Gly Glu Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile 
65                  70                  75                  80  


Gly Ala Thr Pro Ser Leu Glu Asp His Ala Ala Gly Asp Ala Ala Gln 
                85                  90                  95      


Ala Arg Ile Asp Ser Lys Asp Lys Glu Gly Ala Glu Thr Asp Glu Lys 
            100                 105                 110         


Lys Pro Lys Lys Ser Ser Pro Cys Thr Ala Lys Pro Pro Gly Asp Arg 
        115                 120                 125             


Ala Ser Ile Pro Pro His Arg His Thr Ser Ser Ser Thr Ala Pro Pro 
    130                 135                 140                 


Lys Ser Pro Ser Ser Pro Ala Ser Thr Ser Lys Arg Val Thr Pro Arg 
145                 150                 155                 160 


Pro Ala Ser Thr Gly Thr His Glu Thr Lys Ala Lys Gly Gln Glu Met 
                165                 170                 175     


Arg Gly Gly Thr Lys Pro Ala Thr Pro Arg Ser Ala Ala Gly Gln Ala 
            180                 185                 190         


Gln Arg Asn Ser Ser Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Thr 
        195                 200                 205             


Ala Pro Lys Thr Pro Pro Gly Ser Gly Arg Lys Glu Gln Lys Lys Pro 
    210                 215                 220                 


Pro Pro Ala Ala Ala Lys Pro Glu Lys Gly Glu Gln Pro Lys Ser Gly 
225                 230                 235                 240 


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
                245                 250                 255     


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Ala Arg Glu Pro Lys 
            260                 265                 270         


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ala Ser Ala Lys 
        275                 280                 285             


Ser Arg Val Gln Pro Ser Ala Ala Pro Met Pro Asp Leu Lys Asn Val 
    290                 295                 300                 


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
305                 310                 315                 320 


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Phe Ser Ser Val Gln 
                325                 330                 335     


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Ile Pro Gly Gly Gly 
            340                 345                 350         


Ser Val Gln Ile Val Asn Gln Lys Leu Asp Phe Ser Ser Val Gln Ser 
        355                 360                 365             


Arg Cys Gly Ser Lys Asp Asn Ile Lys His Ile Pro Gly Gly Gly Ser 
    370                 375                 380                 


Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser His Val Thr Ser Lys 
385                 390                 395                 400 


Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
                405                 410                 415     


Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Lys Val Gln Ser Lys 
            420                 425                 430         


Ile Gly Ser Leu Asp Asn Ile Ser His Val Pro Gly Gly Gly Asn Lys 
        435                 440                 445             


Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys 
    450                 455                 460                 


Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Thr Ile Ser Gly 
465                 470                 475                 480 


Asp Ala Ser Pro Arg Arg Leu Ser Asn Val Ser Ser Thr Gly Ser Ile 
                485                 490                 495     


Asn Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser 
            500                 505                 510         


Ala Ser Leu Ala Lys Gln Gly Leu 
        515                 520 


<210>  42
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  42

Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys 
1               5                   10                  15      


Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val 
            20                  25                  30          


<210>  43
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys 
1               5                   10                  15      


Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val 
            20                  25                  30      


<210>  44
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  44

Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys 
1               5                   10                  15      


Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val 
            20                  25                  30      


<210>  45
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  45

Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys 
1               5                   10                  15      


Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys 
            20                  25                  30          


Lys Ile Glu 
        35  


<210>  46
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  46

Val Gln Ile Ile Asn Lys Lys 
1               5           


<210>  47
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  47

Val Gln Ile Val Tyr Lys 
1               5       


