
                                SEQUENCE LISTING

<110> Carlo Laudonna
      Lucia De Franceschi

<120> Modulators of Protein Tyrosine Phosphate
  and Uses Thereof

<130> LEUV-002WO

<150> 62/109,555          
<151> 2015-01-29  

<160> 8

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 26
<212> PRT
<213> Homo sapiens

<400> 1
Lys Gln Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His
 1               5                  10                  15      
Gly Phe Ser Glu Asp Phe Glu Glu Val Gln
            20                  25      


<210> 2
<211> 11
<212> PRT
<213> Homo sapiens

<400> 2
His Gly Phe Ser Glu Asp Phe Glu Glu Val Gln
 1               5                  10      


<210> 3
<211> 43
<212> PRT
<213> Homo sapiens

<400> 3
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys
 1               5                  10                  15      
Gly Lys Gln Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln
            20                  25                  30          
His Gly Phe Ser Glu Asp Phe Glu Glu Val Gln
        35                  40              


<210> 4
<211> 16
<212> PRT
<213> Homo sapiens

<400> 4
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys
 1               5                  10                  15      


<210> 5
<211> 662
<212> PRT
<213> Homo sapiens

<400> 5
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Thr Ala His
 1               5                  10                  15      
Phe Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser
            20                  25                  30          
Ile Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys
        35                  40                  45              
Gln Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly
    50                  55                  60                  
Phe Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn
65                  70                  75                  80  
Ile Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg
                85                  90                  95      
Tyr Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro
            100                 105                 110         
Leu Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr
        115                 120                 125             
Val Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro
    130                 135                 140                 
Leu Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn
145                 150                 155                 160 
Thr Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg
                165                 170                 175     
Lys Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn
            180                 185                 190         
Ile Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val
        195                 200                 205             
Arg Arg Phe Ser Ile Arg Asn Thr Lys Val Lys Lys Gly Gln Lys Gly
    210                 215                 220                 
Asn Pro Lys Gly Arg Gln Asn Glu Arg Val Val Ile Gln Tyr His Tyr
225                 230                 235                 240 
Thr Gln Trp Pro Asp Met Gly Val Pro Glu Tyr Ala Leu Pro Val Leu
                245                 250                 255     
Thr Phe Val Arg Arg Ser Ser Ala Ala Arg Met Pro Glu Thr Gly Pro
            260                 265                 270         
Val Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr Tyr Ile
        275                 280                 285             
Val Ile Asp Ser Met Leu Gln Gln Ile Lys Asp Lys Ser Thr Val Asn
    290                 295                 300                 
Val Leu Gly Phe Leu Lys His Ile Arg Thr Gln Arg Asn Tyr Leu Val
305                 310                 315                 320 
Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Asp Ala Leu Leu Glu Ala
                325                 330                 335     
Ile Leu Gly Lys Glu Thr Glu Val Ser Ser Asn Gln Leu His Ser Tyr
            340                 345                 350         
Val Asn Ser Ile Leu Ile Pro Gly Val Gly Gly Lys Thr Arg Leu Glu
        355                 360                 365             
Lys Gln Phe Lys Leu Val Thr Gln Cys Asn Ala Lys Tyr Val Glu Cys
    370                 375                 380                 
Phe Ser Ala Gln Lys Glu Cys Asn Lys Glu Lys Asn Arg Asn Ser Ser
385                 390                 395                 400 
Val Val Pro Ser Glu Arg Ala Arg Val Gly Leu Ala Pro Leu Pro Gly
                405                 410                 415     
Met Lys Gly Thr Asp Tyr Ile Asn Ala Ser Tyr Ile Met Gly Tyr Tyr
            420                 425                 430         
Arg Ser Asn Glu Phe Ile Ile Thr Gln His Pro Leu Pro His Thr Thr
        435                 440                 445             
Lys Asp Phe Trp Arg Met Ile Trp Asp His Asn Ala Gln Ile Ile Val
    450                 455                 460                 
Met Leu Pro Asp Asn Gln Ser Leu Ala Glu Asp Glu Phe Val Tyr Trp
465                 470                 475                 480 
Pro Ser Arg Glu Glu Ser Met Asn Cys Glu Ala Phe Thr Val Thr Leu
                485                 490                 495     
Ile Ser Lys Asp Arg Leu Cys Leu Ser Asn Glu Glu Gln Ile Ile Ile
            500                 505                 510         
His Asp Phe Ile Leu Glu Ala Thr Gln Asp Asp Tyr Val Leu Glu Val
        515                 520                 525             
Arg His Phe Gln Cys Pro Lys Trp Pro Asn Pro Asp Ala Pro Ile Ser
    530                 535                 540                 
Ser Thr Phe Glu Leu Ile Asn Val Ile Lys Glu Glu Ala Leu Thr Arg
545                 550                 555                 560 
Asp Gly Pro Thr Ile Val His Asp Glu Tyr Gly Ala Val Ser Ala Gly
                565                 570                 575     
Met Leu Cys Ala Leu Thr Thr Leu Ser Gln Gln Leu Glu Asn Glu Asn
            580                 585                 590         
Ala Val Asp Val Phe Gln Val Ala Lys Met Ile Asn Leu Met Arg Pro
        595                 600                 605             
Gly Val Phe Thr Asp Ile Glu Gln Tyr Gln Phe Ile Tyr Lys Ala Met
    610                 615                 620                 
Leu Ser Leu Val Ser Thr Lys Glu Asn Gly Asn Gly Pro Met Thr Val
625                 630                 635                 640 
Asp Lys Asn Gly Ala Val Leu Ile Ala Asp Glu Ser Asp Pro Ala Glu
                645                 650                 655     
Ser Met Glu Ser Leu Val
            660         


<210> 6
<211> 649
<212> PRT
<213> Homo sapiens

<400> 6
Thr Ala His Phe Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro
 1               5                  10                  15      
Asn Glu Ser Ile Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile
            20                  25                  30          
Pro Val Lys Gln Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn
        35                  40                  45              
Gln His Gly Phe Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala
    50                  55                  60                  
Asp Met Asn Ile Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His
65                  70                  75                  80  
Lys Asn Arg Tyr Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys
                85                  90                  95      
Leu Arg Pro Leu Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn
            100                 105                 110         
Ala Asn Tyr Val Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr
        115                 120                 125             
Gln Gly Pro Leu Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp
    130                 135                 140                 
Glu Gln Asn Thr Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys
145                 150                 155                 160 
Gly Arg Arg Lys Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu
                165                 170                 175     
Tyr Gly Asn Ile Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys
            180                 185                 190         
Tyr Thr Val Arg Arg Phe Ser Ile Arg Asn Thr Lys Val Lys Lys Gly
        195                 200                 205             
Gln Lys Gly Asn Pro Lys Gly Arg Gln Asn Glu Arg Val Val Ile Gln
    210                 215                 220                 
Tyr His Tyr Thr Gln Trp Pro Asp Met Gly Val Pro Glu Tyr Ala Leu
225                 230                 235                 240 
Pro Val Leu Thr Phe Val Arg Arg Ser Ser Ala Ala Arg Met Pro Glu
                245                 250                 255     
Thr Gly Pro Val Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly
            260                 265                 270         
Thr Tyr Ile Val Ile Asp Ser Met Leu Gln Gln Ile Lys Asp Lys Ser
        275                 280                 285             
Thr Val Asn Val Leu Gly Phe Leu Lys His Ile Arg Thr Gln Arg Asn
    290                 295                 300                 
Tyr Leu Val Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Asp Ala Leu
305                 310                 315                 320 
Leu Glu Ala Ile Leu Gly Lys Glu Thr Glu Val Ser Ser Asn Gln Leu
                325                 330                 335     
His Ser Tyr Val Asn Ser Ile Leu Ile Pro Gly Val Gly Gly Lys Thr
            340                 345                 350         
Arg Leu Glu Lys Gln Phe Lys Leu Val Thr Gln Cys Asn Ala Lys Tyr
        355                 360                 365             
Val Glu Cys Phe Ser Ala Gln Lys Glu Cys Asn Lys Glu Lys Asn Arg
    370                 375                 380                 
Asn Ser Ser Val Val Pro Ser Glu Arg Ala Arg Val Gly Leu Ala Pro
385                 390                 395                 400 
Leu Pro Gly Met Lys Gly Thr Asp Tyr Ile Asn Ala Ser Tyr Ile Met
                405                 410                 415     
Gly Tyr Tyr Arg Ser Asn Glu Phe Ile Ile Thr Gln His Pro Leu Pro
            420                 425                 430         
His Thr Thr Lys Asp Phe Trp Arg Met Ile Trp Asp His Asn Ala Gln
        435                 440                 445             
Ile Ile Val Met Leu Pro Asp Asn Gln Ser Leu Ala Glu Asp Glu Phe
    450                 455                 460                 
Val Tyr Trp Pro Ser Arg Glu Glu Ser Met Asn Cys Glu Ala Phe Thr
465                 470                 475                 480 
Val Thr Leu Ile Ser Lys Asp Arg Leu Cys Leu Ser Asn Glu Glu Gln
                485                 490                 495     
Ile Ile Ile His Asp Phe Ile Leu Glu Ala Thr Gln Asp Asp Tyr Val
            500                 505                 510         
Leu Glu Val Arg His Phe Gln Cys Pro Lys Trp Pro Asn Pro Asp Ala
        515                 520                 525             
Pro Ile Ser Ser Thr Phe Glu Leu Ile Asn Val Ile Lys Glu Glu Ala
    530                 535                 540                 
Leu Thr Arg Asp Gly Pro Thr Ile Val His Asp Glu Tyr Gly Ala Val
545                 550                 555                 560 
Ser Ala Gly Met Leu Cys Ala Leu Thr Thr Leu Ser Gln Gln Leu Glu
                565                 570                 575     
Asn Glu Asn Ala Val Asp Val Phe Gln Val Ala Lys Met Ile Asn Leu
            580                 585                 590         
Met Arg Pro Gly Val Phe Thr Asp Ile Glu Gln Tyr Gln Phe Ile Tyr
        595                 600                 605             
Lys Ala Met Leu Ser Leu Val Ser Thr Lys Glu Asn Gly Asn Gly Pro
    610                 615                 620                 
Met Thr Val Asp Lys Asn Gly Ala Val Leu Ile Ala Asp Glu Ser Asp
625                 630                 635                 640 
Pro Ala Glu Ser Met Glu Ser Leu Val
                645                 


<210> 7
<211> 600
<212> PRT
<213> Homo sapiens

<400> 7
His Gly Phe Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp
 1               5                  10                  15      
Met Asn Ile Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys
            20                  25                  30          
Asn Arg Tyr Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu
        35                  40                  45              
Arg Pro Leu Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala
    50                  55                  60                  
Asn Tyr Val Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln
65                  70                  75                  80  
Gly Pro Leu Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu
                85                  90                  95      
Gln Asn Thr Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly
            100                 105                 110         
Arg Arg Lys Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr
        115                 120                 125             
Gly Asn Ile Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr
    130                 135                 140                 
Thr Val Arg Arg Phe Ser Ile Arg Asn Thr Lys Val Lys Lys Gly Gln
145                 150                 155                 160 
Lys Gly Asn Pro Lys Gly Arg Gln Asn Glu Arg Val Val Ile Gln Tyr
                165                 170                 175     
His Tyr Thr Gln Trp Pro Asp Met Gly Val Pro Glu Tyr Ala Leu Pro
            180                 185                 190         
Val Leu Thr Phe Val Arg Arg Ser Ser Ala Ala Arg Met Pro Glu Thr
        195                 200                 205             
Gly Pro Val Leu Val His Cys Ser Ala Gly Val Gly Arg Thr Gly Thr
    210                 215                 220                 
Tyr Ile Val Ile Asp Ser Met Leu Gln Gln Ile Lys Asp Lys Ser Thr
225                 230                 235                 240 
Val Asn Val Leu Gly Phe Leu Lys His Ile Arg Thr Gln Arg Asn Tyr
                245                 250                 255     
Leu Val Gln Thr Glu Glu Gln Tyr Ile Phe Ile His Asp Ala Leu Leu
            260                 265                 270         
Glu Ala Ile Leu Gly Lys Glu Thr Glu Val Ser Ser Asn Gln Leu His
        275                 280                 285             
Ser Tyr Val Asn Ser Ile Leu Ile Pro Gly Val Gly Gly Lys Thr Arg
    290                 295                 300                 
Leu Glu Lys Gln Phe Lys Leu Val Thr Gln Cys Asn Ala Lys Tyr Val
305                 310                 315                 320 
Glu Cys Phe Ser Ala Gln Lys Glu Cys Asn Lys Glu Lys Asn Arg Asn
                325                 330                 335     
Ser Ser Val Val Pro Ser Glu Arg Ala Arg Val Gly Leu Ala Pro Leu
            340                 345                 350         
Pro Gly Met Lys Gly Thr Asp Tyr Ile Asn Ala Ser Tyr Ile Met Gly
        355                 360                 365             
Tyr Tyr Arg Ser Asn Glu Phe Ile Ile Thr Gln His Pro Leu Pro His
    370                 375                 380                 
Thr Thr Lys Asp Phe Trp Arg Met Ile Trp Asp His Asn Ala Gln Ile
385                 390                 395                 400 
Ile Val Met Leu Pro Asp Asn Gln Ser Leu Ala Glu Asp Glu Phe Val
                405                 410                 415     
Tyr Trp Pro Ser Arg Glu Glu Ser Met Asn Cys Glu Ala Phe Thr Val
            420                 425                 430         
Thr Leu Ile Ser Lys Asp Arg Leu Cys Leu Ser Asn Glu Glu Gln Ile
        435                 440                 445             
Ile Ile His Asp Phe Ile Leu Glu Ala Thr Gln Asp Asp Tyr Val Leu
    450                 455                 460                 
Glu Val Arg His Phe Gln Cys Pro Lys Trp Pro Asn Pro Asp Ala Pro
465                 470                 475                 480 
Ile Ser Ser Thr Phe Glu Leu Ile Asn Val Ile Lys Glu Glu Ala Leu
                485                 490                 495     
Thr Arg Asp Gly Pro Thr Ile Val His Asp Glu Tyr Gly Ala Val Ser
            500                 505                 510         
Ala Gly Met Leu Cys Ala Leu Thr Thr Leu Ser Gln Gln Leu Glu Asn
        515                 520                 525             
Glu Asn Ala Val Asp Val Phe Gln Val Ala Lys Met Ile Asn Leu Met
    530                 535                 540                 
Arg Pro Gly Val Phe Thr Asp Ile Glu Gln Tyr Gln Phe Ile Tyr Lys
545                 550                 555                 560 
Ala Met Leu Ser Leu Val Ser Thr Lys Glu Asn Gly Asn Gly Pro Met
                565                 570                 575     
Thr Val Asp Lys Asn Gly Ala Val Leu Ile Ala Asp Glu Ser Asp Pro
            580                 585                 590         
Ala Glu Ser Met Glu Ser Leu Val
        595                 600 


<210> 8
<211> 717
<212> PRT
<213> Homo sapiens

<400> 8
Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu Gly Tyr Val
 1               5                  10                  15      
Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln Ile Arg Arg
            20                  25                  30          
Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly Ala Tyr Gly
        35                  40                  45              
Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Gly Arg His Gln
    50                  55                  60                  
Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly Glu Glu Tyr
65                  70                  75                  80  
Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser Asn Lys Thr
                85                  90                  95      
Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu Lys Asp Asp
            100                 105                 110         
Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys Ala Glu Lys
        115                 120                 125             
Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly Ser Glu His
    130                 135                 140                 
Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile Phe Phe Tyr
145                 150                 155                 160 
Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser Glu Asn Arg
                165                 170                 175     
Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro Arg Asp Asn
            180                 185                 190         
Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val Val His His
        195                 200                 205             
Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp Leu Leu Pro
    210                 215                 220                 
Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu Thr Thr Pro
225                 230                 235                 240 
Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg Pro Val Pro
                245                 250                 255     
Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe Thr Thr Glu
            260                 265                 270         
Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn Asn Phe Arg
        275                 280                 285             
Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser Ala Val Arg
    290                 295                 300                 
Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn Pro Leu Gly
305                 310                 315                 320 
Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His Met Lys Val
                325                 330                 335     
Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser Gln Pro Glu
            340                 345                 350         
Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser Tyr Ser Trp
        355                 360                 365             
Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys Asp Ser Asp
    370                 375                 380                 
Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp Ser Leu Tyr
385                 390                 395                 400 
Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg Ser Asp Phe
                405                 410                 415     
Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile Phe Gln Gly
            420                 425                 430         
Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro Ala Ser Ser
        435                 440                 445             
Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp Thr Ser Ser
    450                 455                 460                 
Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met Gly Pro Ser
465                 470                 475                 480 
Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr Ser Thr Leu
                485                 490                 495     
Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser Phe Pro Ser
            500                 505                 510         
Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala Ser Lys Gln
        515                 520                 525             
Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala Ser Pro Gly
    530                 535                 540                 
Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly Thr Glu Glu
545                 550                 555                 560 
Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu Arg Glu His
                565                 570                 575     
Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys Ser Gly Val
            580                 585                 590         
Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser Pro Thr Pro
        595                 600                 605             
Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr Ile Pro Gly
    610                 615                 620                 
His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr Gly Gly Arg
625                 630                 635                 640 
Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr Ser Thr Gln
                645                 650                 655     
Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser Asp Pro Lys
            660                 665                 670         
Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly Asp Arg Phe
        675                 680                 685             
Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu Lys Asn Thr
    690                 695                 700                 
Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu
705                 710                 715         

