                               SEQUENCE LISTING

<110> GENENTECH, INC. ET AL.
 
<120> GENE EXPRESSION MARKERS AND TREATMENT OF MULTIPLE SCLEROSIS

<130> P32496-WO

<140>
<141>

<150> 62/108,914
<151> 2015-01-28

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 1859
<212> DNA
<213> Homo sapiens

<400> 1
gcaggcacaa actcatccat ccccagttga ttggaagaaa caacgatgac tcctgggaag       60

acctcattgg tgtcactgct actgctgctg agcctggagg ccatagtgaa ggcaggaatc      120

acaatcccac gaaatccagg atgcccaaat tctgaggaca agaacttccc ccggactgtg      180

atggtcaacc tgaacatcca taaccggaat accaatacca atcccaaaag gtcctcagat      240

tactacaacc gatccacctc accttggaat ctccaccgca atgaggaccc tgagagatat      300

ccctctgtga tctgggaggc aaagtgccgc cacttgggct gcatcaacgc tgatgggaac      360

gtggactacc acatgaactc tgtccccatc cagcaagaga tcctggtcct gcgcagggag      420

cctccacact gccccaactc cttccggctg gagaagatac tggtgtccgt gggctgcacc      480

tgtgtcaccc cgattgtcca ccatgtggcc taagagctct ggggagccca cactccccaa      540

agcagttaga ctatggagag ccgacccagc ccctcaggaa ccctcatcct tcaaagacag      600

cctcatttcg gactaaactc attagagttc ttaaggcagt ttgtccaatt aaagcttcag      660

aggtaacact tggccaagat atgagatctg aattaccttt ccctctttcc aagaaggaag      720

gtttgactga gtaccaattt gcttcttgtt tactttttta agggctttaa gttatttatg      780

tatttaatat gccctgagat aactttgggg tataagattc cattttaatg aattacctac      840

tttattttgt ttgtcttttt aaagaagata agattctggg cttgggaatt ttattattta      900

aaaggtaaaa cctgtattta tttgagctat ttaaggatct atttatgttt aagtatttag      960

aaaaaggtga aaaagcacta ttatcagttc tgcctaggta aatgtaagat agaattaaat     1020

ggcagtgcaa aatttctgag tctttacaac atacggatat agtatttcct cctctttgtt     1080

tttaaaagtt ataacatggc tgaaaagaaa gattaaacct actttcatat gtattaattt     1140

aaattttgca atttgttgag gttttacaag agatacagca agtctaactc tctgttccat     1200

taaaccctta taataaaatc cttctgtaat aataaagttt caaaagaaaa tgtttatttg     1260

ttctcattaa atgtatttta gcaaactcag ctcttcccta ttgggaagag ttatgcaaat     1320

tctcctataa gcaaaacaaa gcatgtcttt gagtaacaat gacctggaaa tacccaaaat     1380

tccaagttct cgatttcaca tgccttcaag actgaacacc gactaaggtt ttcatactat     1440

tagccaatgc tgtagacaga agcattttga taggaataga gcaaataaga taatggccct     1500

gaggaatggc atgtcattat taaagatcat atggggaaaa tgaaaccctc cccaaaatac     1560

aagaagttct gggaggagac attgtcttca gactacaatg tccagtttct cccctagact     1620

caggcttcct ttggagatta aggcccctca gagatcaaca gaccaacatt tttctcttcc     1680

tcaagcaaca ctcctagggc ctggcttctg tctgatcaag gcaccacaca acccagaaag     1740

gagctgatgg ggcagaacga actttaagta tgagaaaagt tcagcccaag taaaataaaa     1800

actcaatcac attcaattcc agagtagttt caagtttcac atcgtaacca ttttcgccc      1859


<210> 2
<211> 155
<212> PRT
<213> Homo sapiens

<400> 2
Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210> 3
<211> 535
<212> DNA
<213> Homo sapiens

<400> 3
agccaccagc gcaacatgac agtgaagacc ctgcatggcc cagccatggt caagtacttg       60

ctgctgtcga tattggggct tgcctttctg agtgaggcgg cagctcggaa aatccccaaa      120

gtaggacata cttttttcca aaagcctgag agttgcccgc ctgtgccagg aggtagtatg      180

aagcttgaca ttggcatcat caatgaaaac cagcgcgttt ccatgtcacg taacatcgag      240

agccgctcca cctccccctg gaattacact gtcacttggg accccaaccg gtacccctcg      300

gaagttgtac aggcccagtg taggaacttg ggctgcatca atgctcaagg aaaggaagac      360

atctccatga attccgttcc catccagcaa gagaccctgg tcgtccggag gaagcaccaa      420

ggctgctctg tttctttcca gttggagaag gtgctggtga ctgttggctg cacctgcgtc      480

acccctgtca tccaccatgt gcagtaagag gtgcatatcc actcagctga agaag           535


<210> 4
<211> 163
<212> PRT
<213> Homo sapiens

<400> 4
Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu 
1               5                   10                  15      


Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys 
            20                  25                  30          


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
        35                  40                  45              


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
    50                  55                  60                  


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
65                  70                  75                  80  


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu 
                85                  90                  95      


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
            100                 105                 110         


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
        115                 120                 125             


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
    130                 135                 140                 


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
145                 150                 155                 160 


His Val Gln 
            


<210> 5
<211> 8608
<212> DNA
<213> Homo sapiens

<400> 5
ctgggcccgg gctggaagcc ggaagcgagc aaagtggagc cgactcgaac tccaccgcgg       60

aaaagaaagc ctcagaacgt tcgttcgctg cgtccccagc cggggccgag ccctccgcga      120

cgccagccgg gccatggggg ccgcacgcag cccgccgtcc gctgtcccgg ggcccctgct      180

ggggctgctc ctgctgctcc tgggcgtgct ggccccgggt ggcgcctccc tgcgactcct      240

ggaccaccgg gcgctggtct gctcccagcc ggggctaaac tgcacggtca agaatagtac      300

ctgcctggat gacagctgga ttcaccctcg aaacctgacc ccctcctccc caaaggacct      360

gcagatccag ctgcactttg cccacaccca acaaggagac ctgttccccg tggctcacat      420

cgaatggaca ctgcagacag acgccagcat cctgtacctc gagggtgcag agttatctgt      480

cctgcagctg aacaccaatg aacgtttgtg cgtcaggttt gagtttctgt ccaaactgag      540

gcatcaccac aggcggtggc gttttacctt cagccacttt gtggttgacc ctgaccagga      600

atatgaggtg accgttcacc acctgcccaa gcccatccct gatggggacc caaaccacca      660

gtccaagaat ttccttgtgc ctgactgtga gcacgccagg atgaaggtaa ccacgccatg      720

catgagctca ggcagcctgt gggaccccaa catcaccgtg gagaccctgg aggcccacca      780

gctgcgtgtg agcttcaccc tgtggaacga atctacccat taccagatcc tgctgaccag      840

ttttccgcac atggagaacc acagttgctt tgagcacatg caccacatac ctgcgcccag      900

accagaagag ttccaccagc gatccaacgt cacactcact ctacgcaacc ttaaagggtg      960

ctgtcgccac caagtgcaga tccagccctt cttcagcagc tgcctcaatg actgcctcag     1020

acactccgcg actgtttcct gcccagaaat gccagacact ccagaaccaa ttccggacta     1080

catgcccctg tgggtgtact ggttcatcac gggcatctcc atcctgctgg tgggctccgt     1140

catcctgctc atcgtctgca tgacctggag gctagctggg cctggaagtg aaaaatacag     1200

tgatgacacc aaatacaccg atggcctgcc tgcggctgac ctgatccccc caccgctgaa     1260

gcccaggaag gtctggatca tctactcagc cgaccacccc ctctacgtgg acgtggtcct     1320

gaaattcgcc cagttcctgc tcaccgcctg cggcacggaa gtggccctgg acctgctgga     1380

agagcaggcc atctcggagg caggagtcat gacctgggtg ggccgtcaga agcaggagat     1440

ggtggagagc aactctaaga tcatcgtcct gtgctcccgc ggcacgcgcg ccaagtggca     1500

ggcgctcctg ggccgggggg cgcctgtgcg gctgcgctgc gaccacggaa agcccgtggg     1560

ggacctgttc actgcagcca tgaacatgat cctcccggac ttcaagaggc cagcctgctt     1620

cggcacctac gtagtctgct acttcagcga ggtcagctgt gacggcgacg tccccgacct     1680

gttcggcgcg gcgccgcggt acccgctcat ggacaggttc gaggaggtgt acttccgcat     1740

ccaggacctg gagatgttcc agccgggccg catgcaccgc gtaggggagc tgtcggggga     1800

caactacctg cggagcccgg gcggcaggca gctccgcgcc gccctggaca ggttccggga     1860

ctggcaggtc cgctgtcccg actggttcga atgtgagaac ctctactcag cagatgacca     1920

ggatgccccg tccctggacg aagaggtgtt tgaggagcca ctgctgcctc cgggaaccgg     1980

catcgtgaag cgggcgcccc tggtgcgcga gcctggctcc caggcctgcc tggccataga     2040

cccgctggtc ggggaggaag gaggagcagc agtggcaaag ctggaacctc acctgcagcc     2100

ccggggtcag ccagcgccgc agcccctcca caccctggtg ctcgccgcag aggagggggc     2160

cctggtggcc gcggtggagc ctgggcccct ggctgacggt gccgcagtcc ggctggcact     2220

ggcgggggag ggcgaggcct gcccgctgct gggcagcccg ggcgctgggc gaaatagcgt     2280

cctcttcctc cccgtggacc ccgaggactc gccccttggc agcagcaccc ccatggcgtc     2340

tcctgacctc cttccagagg acgtgaggga gcacctcgaa ggcttgatgc tctcgctctt     2400

cgagcagagt ctgagctgcc aggcccaggg gggctgcagt agacccgcca tggtcctcac     2460

agacccacac acgccctacg aggaggagca gcggcagtca gtgcagtctg accagggcta     2520

catctccagg agctccccgc agccccccga gggactcacg gaaatggagg aagaggagga     2580

agaggagcag gacccaggga agccggccct gccactctct cccgaggacc tggagagcct     2640

gaggagcctc cagcggcagc tgcttttccg ccagctgcag aagaactcgg gctgggacac     2700

gatggggtca gagtcagagg ggcccagtgc atgagggcgg ctccccaggg accgcccaga     2760

tcccagcttt gagagaggag tgtgtgtgca cgtattcatc tgtgtgtaca tgtctgcatg     2820

tgtatatgtt cgtgtgtgaa atgtaggctt taaaatgtaa atgtctggat tttaatccca     2880

ggcatccctc ctaacttttc tttgtgcagc ggtctggtta tcgtctatcc ccaggggaat     2940

ccacacagcc cgctcccagg agctaatggt agagcgtcct tgaggctcca ttattcgttc     3000

attcagcatt tattgtgcac ctactatgtg gcgggcattt gggataccaa gataaattgc     3060

atgcggcatg gccccagcca tgaaggaact taaccgctag tgccgaggac acgttaaacg     3120

aacaggatgg gccgggcacg gtggctcacg cctgtaatcc cagcacactg ggaggccgag     3180

gcaggtggat cactctgagg tcaggagttt gagccagcct ggccaacatg gtgaaacccc     3240

atctccacta aaaatagaaa aattagccgg gcatggtgac acatgcctgt agtcctagct     3300

acttgggagg ctgaggcagg agaattgctt gaatctggga ggcagaggtt gcagtgagcc     3360

gagattgtgc cattgcactg cagcctggat gacagagcga gactctatct caaaaaaaaa     3420

aaaaaaaaaa gatggtcacg cgggatgtaa acgctgaatg ggccaggtgc agtggctcat     3480

gcttgtaatc ccagcacttt gggaaggcga ggcaggtgga ttgcttgagc tcaggagttc     3540

aagaccagcc tgggcgacat agtgagacct catctctacc taaatttttt tttagtcagt     3600

catggtggca catgcctgta gtcccagcta ctcgggaggc tgatgccaga tgatcacttg     3660

agcccaggag gtagaggctg cagtgagcta taatggtacc attgcaatcc agcctgggca     3720

gcagagtgag accctgtctc aaaaaaaata aaaaagtaga aagatggagt ggaagcctgc     3780

ccagggttgt gagcatgcac gggaaaggca cccaggtcag gggggatccc cgaggagatg     3840

cctgagctga aggattgtgg ttggggaaag cgtagtccca gcaaggaagc agtttgtggg     3900

taagtgctgg gaggtgagtg gagtgagctt gtcagggagc tgctggtgga gcctggaggg     3960

gaaggaggga ggcagtgaga gagatcgggg tggggggtgg ggggatgtcg ccagagctca     4020

ggggtgggga cagccttgtg cgcatcagtc ctgaggcctg gggcaccttt cgtctgatga     4080

gcctctgcat ggagagaggc tgagggctaa acacagctgg atgtcacctg agttcattta     4140

taggaagaga gaaatgtcga ggtgaaacgt aaaagcatct ggcaggaagg tgagtctgaa     4200

gccctgcacc cgcgttccga ctatcagtgg ggagctgtta gcacgtagga ttcttcagag     4260

cagctgggct ggagctcccc tgagctcagg aagccccagg gtgcaagggc aaggaaatga     4320

ggggtggtgg gtcagtgaag atctgggcag accttgtgtg gggaaggggt gctgctgtga     4380

cttcagggtc tgaggtccaa agacagcatt tgaaaagagg ctctgaagcc agtgtttgaa     4440

gaatttgttc ctgaagtacc tcctgggggt aggctagagg cttctggctt cagggtcctg     4500

aagaacacat tgaggtgccg tctgacactg gaatagggtg cccttcattc ctatgcctga     4560

gtccttaact atatttccaa cctccagtga ggaggagaag attcggaaat gtgacaggag     4620

agcaaacagg acagtttgca tgtgtgtgtg cgcacacata catgtgcgtg aaagattatc     4680

aataaaagtg cataaatttg ttgatctggt aagagtttct agcaggaagg tcgagccact     4740

tactgtaggt caagaagttg ctagttgcgg agttttttct tgcagttaga ctttacctag     4800

tggtagcagg gccaccaaag ctctgtgtcc cagatggtgt atggcccata atccacccaa     4860

cagcagcaaa ggaccaggca aaggagaaca ggagcagaag cctcccagcc actagccttt     4920

tgggctcagt ctctccaata atcctggaga ggggcttcgt tgggtctgga cacctaccat     4980

gcattctgtg acctttccct agcttccaat aaataactgt ttgacgccca gagtacagga     5040

taccacaatg cactcttcct gcgtagagca catgttccca tctgctccca ttcctcagga     5100

accttgaatt ctagctctgc tggcctttga gcccatgcca gtaaatgtcc tgatgggcat     5160

tgcctactat ctccagggca gctgcctttg tcctcctaac agctttattg gagtacagtt     5220

cacttaccat acaatccaca attgaccctg cacaatttga tgccggttta gtatagtcac     5280

agttcagcag ccatcagcac agtcagtctt agagtttact acccccaaaa gaaatccagc     5340

cccccttagt caccacccca acctccccat ccctaggcac ccctaggcta ctttgatctc     5400

tgtagacttg cctcttctgg acatgacata gagaaaggag tcataaattc tccaaggtgt     5460

ctgtttcttc tttaatgtca ttccctgttt ctcctcacat tccctcccca tttcctgggc     5520

ccagtctcac actggtcctt gcttacccta aatgctatta attccatcac tctgagtatg     5580

gtgtttgctg tccgctgaat gccaagagct tcaagagtgt gtgtaaataa agccacacct     5640

ttatttttgt attattctga accatggcta ataaattgtt tcaccaagaa atgtctctct     5700

aagaacaggt gccctccacg ctgtgcccct cccacctctt cagctcgtct cctgagtgtg     5760

cagaggtggt tccggttggg aaagaagcag cggagcatct aaccatgcct gtgtccaggc     5820

cgattatgca cgcagccacc aacaagctcc caactcccgc gtagagtttc atgacttttt     5880

cctgcctact atcttgatcc tagttttttt tttgtttttt ttttttttaa ggaataatta     5940

ctttgattca aaaccagttt ctcttttctg cataggaagg tccttgaagg tgtttagggt     6000

ctaaaaaggg tggtgttcgg tctctgaaac atccattcag cagtttgagc tgggatctct     6060

gaatgcaagg gtatgatgga tatacttctt tcttgctttt gttgtgtttt ggttttttgt     6120

ttgtttttaa gtcagggtct ctctgtcacc aggctgtatt acagtggtgc aatcatggct     6180

cactgcagcc tcgacctccc aggctcaagc catctttcca cctcagcctg ccagtggcta     6240

gaactacagg cgtgcaccac tgtgcccggc taatttgtgt gtatatattt tgtagaaatg     6300

gggtttcacc atgttgtcca ggctggtcac gaactcctgg gctcaagcca tctgcccgcc     6360

tcatcctccc aaagtgctgg gattataggc ctgagcccac cgtgcctggc ctttcctgtt     6420

tatctttgaa aattaaatag ggcataagag agaagaagat gtacttacaa tgcagtgggt     6480

ggttttaact ctatagcctt tgggctctgt ggttggtgct ccccttccta aataaatgag     6540

gtgtatgcag ggccctcttc tgccttagcg ccctgccagc tgggactcca gcaaggcccg     6600

gggcacctga ggacagagtg agatggaggg ccgctgctcc agcagccggg cctgcatccc     6660

acaagtcaac tgtgtcggac agaggatcct tacaaagaag aggcagcagg gttgggggct     6720

ggccagctgc tcgtccgccc taggtagctt gctcatctgt aaagtgggtg gggcaggagt     6780

tcccacctca tggggtcctg gcaagcctgc agtatccccg agtggcacca gcctgcttct     6840

ggggcagagc agtttgtgcc ccctgaggta ccactgatcc tctttccctg ctattaggta     6900

ttgctctctt cctccggtgt ttgccttttc agattataga agtaatatgt gttcccatat     6960

ttggcgtctc tcaggagctc aggaagtact tggctgagtg aacatgtcca ttgtggaaaa     7020

atggcaacaa tatggattcc atgggtatat tttatagaag aatatgaaga aaagcagcta     7080

cccctaaacc cattgcacaa gctgttcatg ttaattctgt acccgacgct ttccccacgg     7140

ggcctcccct cactctgaaa tggcatccag gtccatcttg ccctccacct ctgcatggct     7200

ctccatgccc catcgcctct cccagatcct agcactgggt ccacactctc gccctgtcca     7260

tttaggttga tgaaagcagg cagtcacccg ggtgggccag tcttgcctgt gggaggaaca     7320

tgcagtctcc tgtctcatgg tttgaagtgt gccaggaagc ctggcccagc ccacctcccc     7380

ctggagtcct tcccaggagg aataacccct taggtcattg actataagat gagttcgctc     7440

actggatcct tcctctctga tgagacagga agaaggtaca cagtgaccag gtaggaggag     7500

gagagggagt agaaaggagg gatgcgggtg gctggtccct gcatttgcct gcttccctgc     7560

acgggtgtcc cactggccgc ctctgctcac cagtgtcatg ggattctctc agaagatgaa     7620

aacagcccct gcttttttgc tagaatggct gagctttcat ggaaaggaag ctggacccaa     7680

gcaacagccg actaccgaag gttgcctgga gcagtgcaga tgtgggagga agaagggcct     7740

tggtgcacac tggcttttct tcctgactgc aatgtggcat tgtgccagct acctcctctt     7800

tctcggcctc aggaaaatgg agagaaagca gccctgaagg tggctgtgac gagggaaggg     7860

gcagagggcc tgacagtcaa ccacgcgcta tattttcctg ttcttcctta gggcaagaac     7920

tgcatggcca gactcaggca aggcctaggt gtgggctggg cattgcctac acgtgaagag     7980

atcactccgc gtccctactg cacctgtcac aaagtgcctt ctgatatgcc tggcaaacca     8040

aaatcggtga gcgccagctt gcttccctag aagacatttc taaatattca taacatgctt     8100

gctcaaatca atcaccttat tttacatccg ctccagggag aaatgaagac atggtcctac     8160

gttgttctgt aattattttc tatgtaaatt ttgttccttg ttacaattat atatgtctta     8220

ggggaaagga ccatttcaca tgtgtcacct catgtgattc tcaccacagc cctgtgattg     8280

ctcctgtttt ataaataatg acatagttcc agttgatggc caaagccaca gctaacgaga     8340

ggcagagaga gctcaggctc ccaggagctt ccactctcag accttgcctc ccgggctgcc     8400

ctgagtgaaa cgcctgctta gcatttggca cagccagaag cagcaagcta gggtcacaac     8460

acagagaggg gctgtgtaat actggctgcc tctgtgctaa gaaaaaaaaa aaatcactgt     8520

gtgtttgttt attttggtgc aggcccagtg ttcttgctta gacttaatac tacccttcat     8580

gttaaaataa aaccaaacaa aaacccat                                        8608


<210> 6
<211> 866
<212> PRT
<213> Homo sapiens

<400> 6
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210> 7
<211> 2380
<212> DNA
<213> Homo sapiens

<400> 7
acactggcca aacaaaaacg aaagcactcc gtgctggaag taggaggaga gtcaggactc       60

ccaggacaga gagtgcacaa actacccagc acagccccct ccgccccctc tggaggctga      120

agagggattc cagcccctgc cacccacaga cacgggctga ctggggtgtc tgcccccctt      180

gggggggggc agcacagggc ctcaggcctg ggtgccacct ggcacctaga agatgcctgt      240

gccctggttc ttgctgtcct tggcactggg ccgaagccca gtggtccttt ctctggagag      300

gcttgtgggg cctcaggacg ctacccactg ctctccgggc ctctcctgcc gcctctggga      360

cagtgacata ctctgcctgc ctggggacat cgtgcctgct ccgggccccg tgctggcgcc      420

tacgcacctg cagacagagc tggtgctgag gtgccagaag gagaccgact gtgacctctg      480

tctgcgtgtg gctgtccact tggccgtgca tgggcactgg gaagagcctg aagatgagga      540

aaagtttgga ggagcagctg actcaggggt ggaggagcct aggaatgcct ctctccaggc      600

ccaagtcgtg ctctccttcc aggcctaccc tactgcccgc tgcgtcctgc tggaggtgca      660

agtgcctgct gcccttgtgc agtttggtca gtctgtgggc tctgtggtat atgactgctt      720

cgaggctgcc ctagggagtg aggtacgaat ctggtcctat actcagccca ggtacgagaa      780

ggaactcaac cacacacagc agctgcctgc cctgccctgg ctcaacgtgt cagcagatgg      840

tgacaacgtg catctggttc tgaatgtctc tgaggagcag cacttcggcc tctccctgta      900

ctggaatcag gtccagggcc ccccaaaacc ccggtggcac aaaaacctga ctggaccgca      960

gatcattacc ttgaaccaca cagacctggt tccctgcctc tgtattcagg tgtggcctct     1020

ggaacctgac tccgttagga cgaacatctg ccccttcagg gaggaccccc gcgcacacca     1080

gaacctctgg caagccgccc gactgcgact gctgaccctg cagagctggc tgctggacgc     1140

accgtgctcg ctgcccgcag aagcggcact gtgctggcgg gctccgggtg gggacccctg     1200

ccagccactg gtcccaccgc tttcctggga gaacgtcact gtggacaagg ttctcgagtt     1260

cccattgctg aaaggccacc ctaacctctg tgttcaggtg aacagctcgg agaagctgca     1320

gctgcaggag tgcttgtggg ctgactccct ggggcctctc aaagacgatg tgctactgtt     1380

ggagacacga ggcccccagg acaacagatc cctctgtgcc ttggaaccca gtggctgtac     1440

ttcactaccc agcaaagcct ccacgagggc agctcgcctt ggagagtact tactacaaga     1500

cctgcagtca ggccagtgtc tgcagctatg ggacgatgac ttgggagcgc tatgggcctg     1560

ccccatggac aaatacatcc acaagcgctg ggccctcgtg tggctggcct gcctactctt     1620

tgccgctgcg ctttccctca tcctccttct caaaaaggat cacgcgaaag ggtggctgag     1680

gctcttgaaa caggacgtcc gctcgggggc ggccgccagg ggccgcgcgg ctctgctcct     1740

ctactcagcc gatgactcgg gtttcgagcg cctggtgggc gccctggcgt cggccctgtg     1800

ccagctgccg ctgcgcgtgg ccgtagacct gtggagccgt cgtgaactga gcgcgcaggg     1860

gcccgtggct tggtttcacg cgcagcggcg ccagaccctg caggagggcg gcgtggtggt     1920

cttgctcttc tctcccggtg cggtggcgct gtgcagcgag tggctacagg atggggtgtc     1980

cgggcccggg gcgcacggcc cgcacgacgc cttccgcgcc tcgctcagct gcgtgctgcc     2040

cgacttcttg cagggccggg cgcccggcag ctacgtgggg gcctgcttcg acaggctgct     2100

ccacccggac gccgtacccg cccttttccg caccgtgccc gtcttcacac tgccctccca     2160

actgccagac ttcctggggg ccctgcagca gcctcgcgcc ccgcgttccg ggcggctcca     2220

agagagagcg gagcaagtgt cccgggccct tcagccagcc ctggatagct acttccatcc     2280

cccggggact cccgcgccgg gacgcggggt gggaccaggg gcgggacctg gggcggggga     2340

cgggacttaa ataaaggcag acgctgtttt tctaaaaaaa                           2380


<210> 8
<211> 705
<212> PRT
<213> Homo sapiens

<400> 8
Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Gly Leu Ser Cys Arg Leu Trp Asp Ser Asp Ile Leu Cys 
        35                  40                  45              


Leu Pro Gly Asp Ile Val Pro Ala Pro Gly Pro Val Leu Ala Pro Thr 
    50                  55                  60                  


His Leu Gln Thr Glu Leu Val Leu Arg Cys Gln Lys Glu Thr Asp Cys 
65                  70                  75                  80  


Asp Leu Cys Leu Arg Val Ala Val His Leu Ala Val His Gly His Trp 
                85                  90                  95      


Glu Glu Pro Glu Asp Glu Glu Lys Phe Gly Gly Ala Ala Asp Ser Gly 
            100                 105                 110         


Val Glu Glu Pro Arg Asn Ala Ser Leu Gln Ala Gln Val Val Leu Ser 
        115                 120                 125             


Phe Gln Ala Tyr Pro Thr Ala Arg Cys Val Leu Leu Glu Val Gln Val 
    130                 135                 140                 


Pro Ala Ala Leu Val Gln Phe Gly Gln Ser Val Gly Ser Val Val Tyr 
145                 150                 155                 160 


Asp Cys Phe Glu Ala Ala Leu Gly Ser Glu Val Arg Ile Trp Ser Tyr 
                165                 170                 175     


Thr Gln Pro Arg Tyr Glu Lys Glu Leu Asn His Thr Gln Gln Leu Pro 
            180                 185                 190         


Ala Leu Pro Trp Leu Asn Val Ser Ala Asp Gly Asp Asn Val His Leu 
        195                 200                 205             


Val Leu Asn Val Ser Glu Glu Gln His Phe Gly Leu Ser Leu Tyr Trp 
    210                 215                 220                 


Asn Gln Val Gln Gly Pro Pro Lys Pro Arg Trp His Lys Asn Leu Thr 
225                 230                 235                 240 


Gly Pro Gln Ile Ile Thr Leu Asn His Thr Asp Leu Val Pro Cys Leu 
                245                 250                 255     


Cys Ile Gln Val Trp Pro Leu Glu Pro Asp Ser Val Arg Thr Asn Ile 
            260                 265                 270         


Cys Pro Phe Arg Glu Asp Pro Arg Ala His Gln Asn Leu Trp Gln Ala 
        275                 280                 285             


Ala Arg Leu Arg Leu Leu Thr Leu Gln Ser Trp Leu Leu Asp Ala Pro 
    290                 295                 300                 


Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys Trp Arg Ala Pro Gly Gly 
305                 310                 315                 320 


Asp Pro Cys Gln Pro Leu Val Pro Pro Leu Ser Trp Glu Asn Val Thr 
                325                 330                 335     


Val Asp Lys Val Leu Glu Phe Pro Leu Leu Lys Gly His Pro Asn Leu 
            340                 345                 350         


Cys Val Gln Val Asn Ser Ser Glu Lys Leu Gln Leu Gln Glu Cys Leu 
        355                 360                 365             


Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp Asp Val Leu Leu Leu Glu 
    370                 375                 380                 


Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu Cys Ala Leu Glu Pro Ser 
385                 390                 395                 400 


Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser Thr Arg Ala Ala Arg Leu 
                405                 410                 415     


Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser Gly Gln Cys Leu Gln Leu 
            420                 425                 430         


Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala Cys Pro Met Asp Lys Tyr 
        435                 440                 445             


Ile His Lys Arg Trp Ala Leu Val Trp Leu Ala Cys Leu Leu Phe Ala 
    450                 455                 460                 


Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys Lys Asp His Ala Lys Gly 
465                 470                 475                 480 


Trp Leu Arg Leu Leu Lys Gln Asp Val Arg Ser Gly Ala Ala Ala Arg 
                485                 490                 495     


Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala Asp Asp Ser Gly Phe Glu 
            500                 505                 510         


Arg Leu Val Gly Ala Leu Ala Ser Ala Leu Cys Gln Leu Pro Leu Arg 
        515                 520                 525             


Val Ala Val Asp Leu Trp Ser Arg Arg Glu Leu Ser Ala Gln Gly Pro 
    530                 535                 540                 


Val Ala Trp Phe His Ala Gln Arg Arg Gln Thr Leu Gln Glu Gly Gly 
545                 550                 555                 560 


Val Val Val Leu Leu Phe Ser Pro Gly Ala Val Ala Leu Cys Ser Glu 
                565                 570                 575     


Trp Leu Gln Asp Gly Val Ser Gly Pro Gly Ala His Gly Pro His Asp 
            580                 585                 590         


Ala Phe Arg Ala Ser Leu Ser Cys Val Leu Pro Asp Phe Leu Gln Gly 
        595                 600                 605             


Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys Phe Asp Arg Leu Leu His 
    610                 615                 620                 


Pro Asp Ala Val Pro Ala Leu Phe Arg Thr Val Pro Val Phe Thr Leu 
625                 630                 635                 640 


Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala Leu Gln Gln Pro Arg Ala 
                645                 650                 655     


Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala Glu Gln Val Ser Arg Ala 
            660                 665                 670         


Leu Gln Pro Ala Leu Asp Ser Tyr Phe His Pro Pro Gly Thr Pro Ala 
        675                 680                 685             


Pro Gly Arg Gly Val Gly Pro Gly Ala Gly Pro Gly Ala Gly Asp Gly 
    690                 695                 700                 


Thr 
705 


