                         SEQUENCE LISTING

<110>  EMORY UNIVERSITY
       GEORGIA TECH RESEARCH CORPORATION
 
<120>  FACTOR VIII PROTEINS HAVING ANCESTRAL SEQUENCES, EXPRESSION 
       VECTORS, AND USES RELATED THERETO

<130>  15072 PCT

<150>  62/109,964
<151>  2015-01-30

<160>  277   

<170>  PatentIn version 3.5

<210>  1
<211>  2351
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Leu Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Ile Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Lys Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Gln Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Arg Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Asp  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Asp 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Gly Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Asp Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Arg  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Val Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Gln Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  2
<211>  2324
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  2

Met Gln Ile Ala Leu Phe Thr Cys Phe Phe Leu Ser Leu Phe Asn Phe 
1               5                   10                  15      


Cys Ser Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asn Tyr Met Gln Ser Asp Leu Leu Ser Val Leu His Thr Asp Thr 
        35                  40                  45              


Arg Phe Leu Pro Arg Met Pro Thr Ser Phe Pro Phe Asn Thr Ser Ile 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Tyr Met Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Thr Glu Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Lys Glu Gly Ser Leu Ser Lys Glu Arg 
        195                 200                 205             


Thr Gln Met Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Asp Ser Phe Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Thr Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Ile Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Lys 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Trp Gln Lys Lys Asn Asn Glu Glu Met Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Asp Ser Glu Met Asp Met Phe Thr Leu Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys Tyr Pro Lys Thr Trp 
385                 390                 395                 400 


Ile His Tyr Ile Ser Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Ser 
                405                 410                 415     


Val Leu Thr Ser Asp Asp Gly Ser Tyr Lys Ser Gln Tyr Leu Ser Asn 
            420                 425                 430         


Gly Pro His Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Ile Ala 
        435                 440                 445             


Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Thr Ile Gln His Glu Ser 
    450                 455                 460                 


Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu 
465                 470                 475                 480 


Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His 
                485                 490                 495     


Gly Ile Thr Asp Val Ser Pro Leu His Ser Arg Arg Leu Pro Arg Gly 
            500                 505                 510         


Ile Lys His Val Lys Asp Leu Pro Ile Arg Pro Gly Glu Ile Phe Lys 
        515                 520                 525             


Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro 
    530                 535                 540                 


Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Pro Glu Arg Asp 
545                 550                 555                 560 


Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser 
                565                 570                 575     


Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val Ile 
            580                 585                 590         


Leu Phe Ser Val Phe Asp Glu Asn Gln Ser Trp Tyr Ile Thr Glu Asn 
        595                 600                 605             


Met Gln Arg Phe Leu Pro Asn Ala Ala Asp Thr Gln Pro Gln Asp Pro 
    610                 615                 620                 


Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe 
625                 630                 635                 640 


Asp Ser Leu Gln Leu Thr Val Cys Leu His Glu Val Ala Tyr Trp Tyr 
                645                 650                 655     


Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Ile Phe Phe Ser 
            660                 665                 670         


Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu 
        675                 680                 685             


Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly 
    690                 695                 700                 


Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Lys Arg Gly Met 
705                 710                 715                 720 


Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Ser Thr Ser Asp Tyr 
                725                 730                 735     


Tyr Glu Glu Ile Tyr Glu Asp Ile Pro Thr Gln Leu Val Asn Asp Asn 
            740                 745                 750         


Asn Val Ile Glu Pro Arg Ser Phe Phe Gln Asn Ser Asn His Pro Asn 
        755                 760                 765             


Thr Arg Lys Lys Lys Phe Lys Ala Thr Thr Ile Pro Glu Asn Asp Ile 
    770                 775                 780                 


Glu Lys Ile Glu Pro Gln Phe Gly Glu Thr Ala Glu Met Leu Lys Val 
785                 790                 795                 800 


Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln Ser Pro 
                805                 810                 815     


Thr Pro His Gly Leu Ser Leu Ser Asp Asn Gln Glu Ala Ile Tyr Glu 
            820                 825                 830         


Ala Ile Pro Asp Asp His Ser Pro Asp Ala Ile Asp Ser Asn Glu Gly 
        835                 840                 845             


Pro Ser Lys Val Thr Gln Leu Arg Pro Glu Leu His His Ser Gly Lys 
    850                 855                 860                 


Ile Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Ser Asn Lys Asn 
865                 870                 875                 880 


Leu Glu Thr Thr Ile Glu Val Lys Trp Lys Lys Leu Asp Leu Gln Val 
                885                 890                 895     


Ser Ser Leu Pro Asn Asn Leu Met Thr Thr Thr Ile Leu Ser Asp Asn 
            900                 905                 910         


Leu Thr Ala Thr Ser Glu Lys Thr Asp Ser Ser Gly Ser Pro Asp Met 
        915                 920                 925             


Pro Val His Phe Ser Ser Lys Leu Ser Thr Thr Ala Phe Gly Lys Lys 
    930                 935                 940                 


Ser Tyr Pro Leu Ile Gly Ser His Val Pro Leu Asn Ile Ser Glu Arg 
945                 950                 955                 960 


Asn Ser Asp Ser Asn Leu Leu Asp Ala Thr Leu Met Asn Asn Gln Glu 
                965                 970                 975     


Ser Ser Leu Gly Asp Asn Ile Ser Ser Met Glu Asn Asp Arg Leu Leu 
            980                 985                 990         


Lys Glu Lys Arg Phe His Gly Ile  Ala Leu Leu Thr Lys  Asp Asn Thr 
        995                 1000                 1005             


Leu Phe  Lys Asp Asn Ile Ser  Leu Met Lys Thr Asn  Lys Thr Tyr 
    1010                 1015                 1020             


Asn His  Ser Thr Thr Asn Gly  Lys Ala His Ile Asp  Ser Pro Thr 
    1025                 1030                 1035             


Ser Ile  Glu Asn Ser Thr Ala  Val Leu Gln Asp Thr  Ile Leu Lys 
    1040                 1045                 1050             


Ile Asn  Ser Glu Ile Gln Glu  Val Thr Ser Leu Ile  His Asp Gly 
    1055                 1060                 1065             


Thr Leu  Ser Gly Lys Asn Thr  Thr Tyr Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Leu Asn  Arg Thr Thr Ser Ser  Lys Asn Lys Glu Ile  Phe His Gln 
    1085                 1090                 1095             


Lys Asp  Glu Asp Pro Val Pro  Gln Asp Thr Glu Asn  Thr Ile Met 
    1100                 1105                 1110             


Pro Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Asn Trp Met 
    1115                 1120                 1125             


Lys Arg  Thr Asn Gly Asn Asn  Ser Leu Asn Ser Glu  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Tyr  Leu Met Leu Glu Lys  Ser Val Lys 
    1145                 1150                 1155             


Asn Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Ile  Val Glu Gln 
    1160                 1165                 1170             


Asp Glu  Phe Thr Lys Asp Thr  Gly Leu Lys Asp Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Asn  Met Ser Ile Phe Leu  Thr Thr Leu Ala Asn  Val Gln Glu 
    1190                 1195                 1200             


Asn Asp  Met His Asn Gln Glu  Lys Asn Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Lys Glu  Ala Leu Ile Glu Glu  Lys Val Val Leu Pro  Gln Val His 
    1220                 1225                 1230             


Ile Ala  Thr Gly Ser Lys Asn  Phe Leu Lys Asp Ile  Phe Phe Leu 
    1235                 1240                 1245             


Gly Thr  Arg Gln Asn Val Ser  Leu Asp Glu Asp Ile  Tyr Val Pro 
    1250                 1255                 1260             


Val Leu  Gln Asp Ile Ser Ser  Ile Asn Asn Ser Thr  Asn Thr Val 
    1265                 1270                 1275             


Glu Ile  His Met Ala His Phe  Phe Lys Arg Arg Glu  Asp Glu Glu 
    1280                 1285                 1290             


Thr Asn  Ser Glu Gly Leu Val  Asn Lys Thr Arg Glu  Met Val Lys 
    1295                 1300                 1305             


Asn Tyr  Pro Ser Gln Lys Asn  Ile Ile Thr Gln Arg  Ser Lys Arg 
    1310                 1315                 1320             


Ala Leu  Gly Gln Phe Arg Leu  Pro Leu Ala Ser Thr  Gln Trp Pro 
    1325                 1330                 1335             


Gln Thr  Met Asn Tyr Leu Thr  Gln Ser Ile Ile Thr  Gln Ile Asp 
    1340                 1345                 1350             


His Ser  Lys Glu Gly Glu Lys  Ser Ile Thr Gln Ser  Ser Leu Ser 
    1355                 1360                 1365             


Asp Ser  Ser Met Ile Lys Ser  Thr Thr Gln Thr Asn  Ser Ser Gly 
    1370                 1375                 1380             


Leu His  Ile Val Lys Thr Ser  Ala Phe Pro Pro Thr  Asp Leu Lys 
    1385                 1390                 1395             


Arg Ile  Pro Phe Gln Asp Lys  Phe Phe His Val Leu  Ala Ser Ser 
    1400                 1405                 1410             


Tyr Thr  Tyr Asp Phe Lys Thr  Lys Ser Ser Arg Ile  Gln Glu Ser 
    1415                 1420                 1425             


Ser His  Phe Leu Lys Glu Thr  Lys Ile Asn Asn Ser  Ser Leu Ala 
    1430                 1435                 1440             


Ile Leu  Pro Trp Glu Met Ile  Ile Asn Gln Gly Lys  Phe Ala Ser 
    1445                 1450                 1455             


Pro Gly  Thr Ser Asn Thr Asn  Ser Val Thr Tyr Lys  Lys Leu Glu 
    1460                 1465                 1470             


Asn Ile  Val Leu Leu Lys Pro  Val Leu Pro Glu Glu  Ser Gly Lys 
    1475                 1480                 1485             


Val Glu  Leu Leu Pro Gln Val  Ser Ile His Glu Glu  Glu Leu Leu 
    1490                 1495                 1500             


Pro Thr  Glu Thr Ser His Gly  Ser Pro Gly His Leu  Asp Leu Met 
    1505                 1510                 1515             


Lys Glu  Val Phe Leu Gln Lys  Thr Gln Gly Pro Ile  Lys Trp Asn 
    1520                 1525                 1530             


Lys Ala  Lys Arg His Gly Glu  Ser Glu Leu Lys Gly  Thr Thr Glu 
    1535                 1540                 1545             


Ser Ser  Glu Lys Thr Pro Ser  Lys Leu Leu Asp His  Leu Ala Trp 
    1550                 1555                 1560             


Asp Asn  His Tyr Ala Ala Gln  Ile Pro Lys Asp Lys  Trp Lys Ser 
    1565                 1570                 1575             


Lys Glu  Lys Ser Pro Glu Ile  Thr Ser Ile Lys Arg  Glu Asp Thr 
    1580                 1585                 1590             


Ile Leu  Ser Leu Asn Pro His  Glu Asn Asn His Ser  Ile Val Ala 
    1595                 1600                 1605             


Asn Glu  Lys Gln Asn Trp Pro  Gln Arg Glu Ala Thr  Trp Val Lys 
    1610                 1615                 1620             


Gln Gly  Gln Thr Gln Arg Leu  Cys Ser Gln Asn Pro  Pro Val Leu 
    1625                 1630                 1635             


Lys Arg  His Gln Arg Glu Leu  Ser Ala Leu Gln Ser  Glu Gln Glu 
    1640                 1645                 1650             


Ala Thr  Asp Tyr Asp Asp Ser  Ile Thr Ile Glu Thr  Asn Glu Asp 
    1655                 1660                 1665             


Phe Asp  Ile Tyr Gly Glu Asp  Ile Lys Gln Gly Pro  Arg Ser Phe 
    1670                 1675                 1680             


Gln Gln  Lys Thr Arg His Tyr  Phe Ile Ala Ala Val  Glu Arg Leu 
    1685                 1690                 1695             


Trp Asp  Tyr Gly Met Ser Thr  Ser Pro His Val Leu  Arg Asn Arg 
    1700                 1705                 1710             


Asp Gln  Ser Gly Asn Ala Pro  Gln Phe Lys Lys Val  Val Phe Gln 
    1715                 1720                 1725             


Glu Phe  Thr Asp Gly Ser Phe  Ser Gln Pro Leu Tyr  Arg Gly Glu 
    1730                 1735                 1740             


Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro Tyr Ile  Arg Ala Glu 
    1745                 1750                 1755             


Val Glu  Asp Asn Ile Met Val  Thr Phe Lys Asn Gln  Ala Ser Arg 
    1760                 1765                 1770             


Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser Tyr Lys  Glu Asp Gln 
    1775                 1780                 1785             


Arg Gln  Gly Glu Glu Pro Arg  Arg Asn Phe Val Lys  Pro Asn Glu 
    1790                 1795                 1800             


Thr Lys  Ile Tyr Phe Trp Lys  Val Gln His His Met  Ala Pro Thr 
    1805                 1810                 1815             


Glu Asp  Glu Phe Asp Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val 
    1820                 1825                 1830             


Asp Leu  Glu Arg Asp Met His  Ser Gly Leu Ile Gly  Pro Leu Leu 
    1835                 1840                 1845             


Ile Cys  His Thr Asn Thr Leu  Asn Pro Ala His Gly  Arg Gln Val 
    1850                 1855                 1860             


Ala Val  Gln Glu Phe Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr 
    1865                 1870                 1875             


Lys Ser  Trp Tyr Phe Thr Glu  Asn Val Glu Arg Asn  Cys Lys Thr 
    1880                 1885                 1890             


Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr Leu Lys  Glu Asn Tyr 
    1895                 1900                 1905             


Arg Phe  His Ala Ile Asn Gly  Tyr Val Met Asp Thr  Leu Pro Gly 
    1910                 1915                 1920             


Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser 
    1925                 1930                 1935             


Met Gly  Ser Asn Glu Asn Ile  Gln Ser Ile His Phe  Ser Gly His 
    1940                 1945                 1950             


Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr Lys Met  Ala Val Tyr 
    1955                 1960                 1965             


Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val Glu Met  Leu Pro Ser 
    1970                 1975                 1980             


Arg Ala  Gly Ile Trp Arg Val  Glu Cys Leu Ile Gly  Glu His Leu 
    1985                 1990                 1995             


Gln Ala  Gly Met Ser Thr Leu  Phe Leu Val Tyr Ser  Lys Gln Cys 
    2000                 2005                 2010             


Gln Ile  Pro Leu Gly Met Ala  Ser Gly Ser Ile Arg  Asp Phe Gln 
    2015                 2020                 2025             


Ile Thr  Ala Ser Gly His Tyr  Gly Gln Trp Ala Pro  Asn Leu Ala 
    2030                 2035                 2040             


Arg Leu  His His Ser Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu 
    2045                 2050                 2055             


Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu Thr Pro  Met Ile Ile 
    2060                 2065                 2070             


His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu 
    2075                 2080                 2085             


Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys 
    2090                 2095                 2100             


Trp Leu  Ser Tyr Arg Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe 
    2105                 2110                 2115             


Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys His Asn  Ser Phe Asn 
    2120                 2125                 2130             


Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu His Pro  Thr His Ser 
    2135                 2140                 2145             


Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu 
    2150                 2155                 2160             


Asn Ser  Cys Ser Ile Pro Leu  Gly Met Glu Asn Lys  Val Ile Ser 
    2165                 2170                 2175             


Asp Thr  Gln Ile Thr Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala 
    2180                 2185                 2190             


Thr Trp  Ser Pro Ser Gln Ala  Arg Leu His Leu Gln  Gly Arg Thr 
    2195                 2200                 2205             


Asn Ala  Trp Arg Pro Gln Val  Asn Asp Pro Lys Glu  Trp Leu Gln 
    2210                 2215                 2220             


Val Asp  Leu Gln Lys Thr Met  Lys Val Thr Gly Ile  Ile Thr Gln 
    2225                 2230                 2235             


Gly Val  Lys Ser Leu Phe Thr  Ser Met Phe Val Lys  Glu Phe Leu 
    2240                 2245                 2250             


Ile Ser  Ser Ser Gln Asp Gly  His His Trp Thr His  Ile Leu His 
    2255                 2260                 2265             


Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn Gln Asp  Ser Ser Thr 
    2270                 2275                 2280             


Pro Met  Val Asn Ser Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu 
    2285                 2290                 2295             


Arg Ile  His Pro Gln Ile Trp  Glu His Gln Ile Ala  Leu Arg Leu 
    2300                 2305                 2310             


Glu Ile  Leu Gly Cys Glu Ala  Gln Gln Leu Tyr 
    2315                 2320                 


<210>  3
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  3

Met Gln Ile Ala Leu Phe Thr Cys Phe Phe Leu Ser Leu Phe Asn Phe 
1               5                   10                  15      


Cys Ser Ser 
            


<210>  4
<211>  372
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  4

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asn Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Leu Ser Val Leu His Thr Asp Thr Arg Phe Leu 
            20                  25                  30          


Pro Arg Met Pro Thr Ser Phe Pro Phe Asn Thr Ser Ile Met Tyr Lys 
        35                  40                  45              


Lys Thr Val Phe Val Glu Tyr Met Asp His Leu Phe Asn Ile Ala Lys 
    50                  55                  60                  


Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Trp Thr Glu 
65                  70                  75                  80  


Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro 
                85                  90                  95      


Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly 
            100                 105                 110         


Ala Glu Tyr Glu Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys 
        115                 120                 125             


Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu 
    130                 135                 140                 


Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr Ser Tyr Leu 
145                 150                 155                 160 


Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala 
                165                 170                 175     


Leu Leu Val Cys Lys Glu Gly Ser Leu Ser Lys Glu Arg Thr Gln Met 
            180                 185                 190         


Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser 
        195                 200                 205             


Trp His Ser Glu Thr Lys Asp Ser Phe Thr Gln Ala Met Asp Ser Ala 
    210                 215                 220                 


Ser Thr Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn 
225                 230                 235                 240 


Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp 
                245                 250                 255     


His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu 
            260                 265                 270         


Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu 
        275                 280                 285             


Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Ile Asp Leu 
    290                 295                 300                 


Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Lys His Asp Gly 
305                 310                 315                 320 


Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Trp 
                325                 330                 335     


Gln Lys Lys Asn Asn Glu Glu Met Glu Asp Tyr Asp Asp Asp Leu Asp 
            340                 345                 350         


Ser Glu Met Asp Met Phe Thr Leu Asp Asp Asp Asn Ser Pro Phe Ile 
        355                 360                 365             


Gln Ile Arg Ser 
    370         


<210>  5
<211>  367
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  5

Val Ala Lys Lys Tyr Pro Lys Thr Trp Ile His Tyr Ile Ser Ala Glu 
1               5                   10                  15      


Glu Glu Asp Trp Asp Tyr Ala Pro Ser Val Leu Thr Ser Asp Asp Gly 
            20                  25                  30          


Ser Tyr Lys Ser Gln Tyr Leu Ser Asn Gly Pro His Arg Ile Gly Arg 
        35                  40                  45              


Lys Tyr Lys Lys Val Arg Phe Ile Ala Tyr Thr Asp Glu Thr Phe Lys 
    50                  55                  60                  


Thr Arg Glu Thr Ile Gln His Glu Ser Gly Ile Leu Gly Pro Leu Leu 
65                  70                  75                  80  


Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala 
                85                  90                  95      


Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Ser Pro 
            100                 105                 110         


Leu His Ser Arg Arg Leu Pro Arg Gly Ile Lys His Val Lys Asp Leu 
        115                 120                 125             


Pro Ile Arg Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val 
    130                 135                 140                 


Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr 
145                 150                 155                 160 


Ser Ser Phe Ile Asn Pro Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly 
                165                 170                 175     


Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln 
            180                 185                 190         


Met Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu 
        195                 200                 205             


Asn Gln Ser Trp Tyr Ile Thr Glu Asn Met Gln Arg Phe Leu Pro Asn 
    210                 215                 220                 


Ala Ala Asp Thr Gln Pro Gln Asp Pro Glu Phe Gln Ala Ser Asn Ile 
225                 230                 235                 240 


Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Thr Val 
                245                 250                 255     


Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Val Gly Ala Gln 
            260                 265                 270         


Thr Asp Phe Leu Ser Ile Phe Phe Ser Gly Tyr Thr Phe Lys His Lys 
        275                 280                 285             


Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr 
    290                 295                 300                 


Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Val Leu Gly Cys His 
305                 310                 315                 320 


Asn Ser Asp Phe Arg Lys Arg Gly Met Thr Ala Leu Leu Lys Val Ser 
                325                 330                 335     


Ser Cys Asp Lys Ser Thr Ser Asp Tyr Tyr Glu Glu Ile Tyr Glu Asp 
            340                 345                 350         


Ile Pro Thr Gln Leu Val Asn Asp Asn Asn Val Ile Glu Pro Arg 
        355                 360                 365         


<210>  6
<211>  885
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  6

Ser Phe Phe Gln Asn Ser Asn His Pro Asn Thr Arg Lys Lys Lys Phe 
1               5                   10                  15      


Lys Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Ile Glu Pro Gln 
            20                  25                  30          


Phe Gly Glu Thr Ala Glu Met Leu Lys Val Gln Ser Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Gly Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Asn Gln Glu Ala Ile Tyr Glu Ala Ile Pro Asp Asp His 
65                  70                  75                  80  


Ser Pro Asp Ala Ile Asp Ser Asn Glu Gly Pro Ser Lys Val Thr Gln 
                85                  90                  95      


Leu Arg Pro Glu Leu His His Ser Gly Lys Ile Val Phe Thr Pro Glu 
            100                 105                 110         


Pro Gly Leu Gln Leu Arg Ser Asn Lys Asn Leu Glu Thr Thr Ile Glu 
        115                 120                 125             


Val Lys Trp Lys Lys Leu Asp Leu Gln Val Ser Ser Leu Pro Asn Asn 
    130                 135                 140                 


Leu Met Thr Thr Thr Ile Leu Ser Asp Asn Leu Thr Ala Thr Ser Glu 
145                 150                 155                 160 


Lys Thr Asp Ser Ser Gly Ser Pro Asp Met Pro Val His Phe Ser Ser 
                165                 170                 175     


Lys Leu Ser Thr Thr Ala Phe Gly Lys Lys Ser Tyr Pro Leu Ile Gly 
            180                 185                 190         


Ser His Val Pro Leu Asn Ile Ser Glu Arg Asn Ser Asp Ser Asn Leu 
        195                 200                 205             


Leu Asp Ala Thr Leu Met Asn Asn Gln Glu Ser Ser Leu Gly Asp Asn 
    210                 215                 220                 


Ile Ser Ser Met Glu Asn Asp Arg Leu Leu Lys Glu Lys Arg Phe His 
225                 230                 235                 240 


Gly Ile Ala Leu Leu Thr Lys Asp Asn Thr Leu Phe Lys Asp Asn Ile 
                245                 250                 255     


Ser Leu Met Lys Thr Asn Lys Thr Tyr Asn His Ser Thr Thr Asn Gly 
            260                 265                 270         


Lys Ala His Ile Asp Ser Pro Thr Ser Ile Glu Asn Ser Thr Ala Val 
        275                 280                 285             


Leu Gln Asp Thr Ile Leu Lys Ile Asn Ser Glu Ile Gln Glu Val Thr 
    290                 295                 300                 


Ser Leu Ile His Asp Gly Thr Leu Ser Gly Lys Asn Thr Thr Tyr Leu 
305                 310                 315                 320 


Arg Leu Asn His Met Leu Asn Arg Thr Thr Ser Ser Lys Asn Lys Glu 
                325                 330                 335     


Ile Phe His Gln Lys Asp Glu Asp Pro Val Pro Gln Asp Thr Glu Asn 
            340                 345                 350         


Thr Ile Met Pro Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala Asn 
        355                 360                 365             


Trp Met Lys Arg Thr Asn Gly Asn Asn Ser Leu Asn Ser Glu Gln Gly 
    370                 375                 380                 


Pro Ser Pro Lys Gln Leu Val Tyr Leu Met Leu Glu Lys Ser Val Lys 
385                 390                 395                 400 


Asn Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Ile Val Glu Gln Asp 
                405                 410                 415     


Glu Phe Thr Lys Asp Thr Gly Leu Lys Asp Met Val Phe Pro Ser Asn 
            420                 425                 430         


Met Ser Ile Phe Leu Thr Thr Leu Ala Asn Val Gln Glu Asn Asp Met 
        435                 440                 445             


His Asn Gln Glu Lys Asn Ile Gln Glu Glu Ile Glu Lys Glu Ala Leu 
    450                 455                 460                 


Ile Glu Glu Lys Val Val Leu Pro Gln Val His Ile Ala Thr Gly Ser 
465                 470                 475                 480 


Lys Asn Phe Leu Lys Asp Ile Phe Phe Leu Gly Thr Arg Gln Asn Val 
                485                 490                 495     


Ser Leu Asp Glu Asp Ile Tyr Val Pro Val Leu Gln Asp Ile Ser Ser 
            500                 505                 510         


Ile Asn Asn Ser Thr Asn Thr Val Glu Ile His Met Ala His Phe Phe 
        515                 520                 525             


Lys Arg Arg Glu Asp Glu Glu Thr Asn Ser Glu Gly Leu Val Asn Lys 
    530                 535                 540                 


Thr Arg Glu Met Val Lys Asn Tyr Pro Ser Gln Lys Asn Ile Ile Thr 
545                 550                 555                 560 


Gln Arg Ser Lys Arg Ala Leu Gly Gln Phe Arg Leu Pro Leu Ala Ser 
                565                 570                 575     


Thr Gln Trp Pro Gln Thr Met Asn Tyr Leu Thr Gln Ser Ile Ile Thr 
            580                 585                 590         


Gln Ile Asp His Ser Lys Glu Gly Glu Lys Ser Ile Thr Gln Ser Ser 
        595                 600                 605             


Leu Ser Asp Ser Ser Met Ile Lys Ser Thr Thr Gln Thr Asn Ser Ser 
    610                 615                 620                 


Gly Leu His Ile Val Lys Thr Ser Ala Phe Pro Pro Thr Asp Leu Lys 
625                 630                 635                 640 


Arg Ile Pro Phe Gln Asp Lys Phe Phe His Val Leu Ala Ser Ser Tyr 
                645                 650                 655     


Thr Tyr Asp Phe Lys Thr Lys Ser Ser Arg Ile Gln Glu Ser Ser His 
            660                 665                 670         


Phe Leu Lys Glu Thr Lys Ile Asn Asn Ser Ser Leu Ala Ile Leu Pro 
        675                 680                 685             


Trp Glu Met Ile Ile Asn Gln Gly Lys Phe Ala Ser Pro Gly Thr Ser 
    690                 695                 700                 


Asn Thr Asn Ser Val Thr Tyr Lys Lys Leu Glu Asn Ile Val Leu Leu 
705                 710                 715                 720 


Lys Pro Val Leu Pro Glu Glu Ser Gly Lys Val Glu Leu Leu Pro Gln 
                725                 730                 735     


Val Ser Ile His Glu Glu Glu Leu Leu Pro Thr Glu Thr Ser His Gly 
            740                 745                 750         


Ser Pro Gly His Leu Asp Leu Met Lys Glu Val Phe Leu Gln Lys Thr 
        755                 760                 765             


Gln Gly Pro Ile Lys Trp Asn Lys Ala Lys Arg His Gly Glu Ser Glu 
    770                 775                 780                 


Leu Lys Gly Thr Thr Glu Ser Ser Glu Lys Thr Pro Ser Lys Leu Leu 
785                 790                 795                 800 


Asp His Leu Ala Trp Asp Asn His Tyr Ala Ala Gln Ile Pro Lys Asp 
                805                 810                 815     


Lys Trp Lys Ser Lys Glu Lys Ser Pro Glu Ile Thr Ser Ile Lys Arg 
            820                 825                 830         


Glu Asp Thr Ile Leu Ser Leu Asn Pro His Glu Asn Asn His Ser Ile 
        835                 840                 845             


Val Ala Asn Glu Lys Gln Asn Trp Pro Gln Arg Glu Ala Thr Trp Val 
    850                 855                 860                 


Lys Gln Gly Gln Thr Gln Arg Leu Cys Ser Gln Asn Pro Pro Val Leu 
865                 870                 875                 880 


Lys Arg His Gln Arg 
                885 


<210>  7
<211>  38
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  7

Glu Leu Ser Ala Leu Gln Ser Glu Gln Glu Ala Thr Asp Tyr Asp Asp 
1               5                   10                  15      


Ser Ile Thr Ile Glu Thr Asn Glu Asp Phe Asp Ile Tyr Gly Glu Asp 
            20                  25                  30          


Ile Lys Gln Gly Pro Arg 
        35              


<210>  8
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  8

Ser Phe Gln Gln Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg 
1               5                   10                  15      


Leu Trp Asp Tyr Gly Met Ser Thr Ser Pro His Val Leu Arg Asn Arg 
            20                  25                  30          


Asp Gln Ser Gly Asn Ala Pro Gln Phe Lys Lys Val Val Phe Gln Glu 
        35                  40                  45              


Phe Thr Asp Gly Ser Phe Ser Gln Pro Leu Tyr Arg Gly Glu Leu Asn 
    50                  55                  60                  


Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp 
65                  70                  75                  80  


Asn Ile Met Val Thr Phe Lys Asn Gln Ala Ser Arg Pro Tyr Ser Phe 
                85                  90                  95      


Tyr Ser Ser Leu Ile Ser Tyr Lys Glu Asp Gln Arg Gln Gly Glu Glu 
            100                 105                 110         


Pro Arg Arg Asn Phe Val Lys Pro Asn Glu Thr Lys Ile Tyr Phe Trp 
        115                 120                 125             


Lys Val Gln His His Met Ala Pro Thr Glu Asp Glu Phe Asp Cys Lys 
    130                 135                 140                 


Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Arg Asp Met His Ser 
145                 150                 155                 160 


Gly Leu Ile Gly Pro Leu Leu Ile Cys His Thr Asn Thr Leu Asn Pro 
                165                 170                 175     


Ala His Gly Arg Gln Val Ala Val Gln Glu Phe Ala Leu Phe Phe Thr 
            180                 185                 190         


Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Val Glu Arg 
        195                 200                 205             


Asn Cys Lys Thr Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Leu Lys 
    210                 215                 220                 


Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Val Met Asp Thr Leu 
225                 230                 235                 240 


Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu 
                245                 250                 255     


Ser Met Gly Ser Asn Glu Asn Ile Gln Ser Ile His Phe Ser Gly His 
            260                 265                 270         


Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Val Tyr Asn 
        275                 280                 285             


Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Arg Ala 
    290                 295                 300                 


Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu Gln Ala Gly 
305                 310                 315                 320 


Met Ser Thr Leu Phe Leu Val Tyr Ser Lys 
                325                 330 


<210>  9
<211>  153
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  9

Gln Cys Gln Ile Pro Leu Gly Met Ala Ser Gly Ser Ile Arg Asp Phe 
1               5                   10                  15      


Gln Ile Thr Ala Ser Gly His Tyr Gly Gln Trp Ala Pro Asn Leu Ala 
            20                  25                  30          


Arg Leu His His Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro 
        35                  40                  45              


Phe Ser Trp Ile Lys Val Asp Leu Leu Thr Pro Met Ile Ile His Gly 
    50                  55                  60                  


Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser 
65                  70                  75                  80  


Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Leu Ser Tyr 
                85                  90                  95      


Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp 
            100                 105                 110         


Ser Ser Gly Ile Lys His Asn Ser Phe Asn Pro Pro Ile Ile Ala Arg 
        115                 120                 125             


Tyr Ile Arg Leu His Pro Thr His Ser Ser Ile Arg Ser Thr Leu Arg 
    130                 135                 140                 


Met Glu Leu Met Gly Cys Asp Leu Asn 
145                 150             


<210>  10
<211>  160
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  10

Ser Cys Ser Ile Pro Leu Gly Met Glu Asn Lys Val Ile Ser Asp Thr 
1               5                   10                  15      


Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser 
            20                  25                  30          


Pro Ser Gln Ala Arg Leu His Leu Gln Gly Arg Thr Asn Ala Trp Arg 
        35                  40                  45              


Pro Gln Val Asn Asp Pro Lys Glu Trp Leu Gln Val Asp Leu Gln Lys 
    50                  55                  60                  


Thr Met Lys Val Thr Gly Ile Ile Thr Gln Gly Val Lys Ser Leu Phe 
65                  70                  75                  80  


Thr Ser Met Phe Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly 
                85                  90                  95      


His His Trp Thr His Ile Leu His Asn Gly Lys Val Lys Val Phe Gln 
            100                 105                 110         


Gly Asn Gln Asp Ser Ser Thr Pro Met Val Asn Ser Leu Asp Pro Pro 
        115                 120                 125             


Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ile Trp Glu His Gln 
    130                 135                 140                 


Ile Ala Leu Arg Leu Glu Ile Leu Gly Cys Glu Ala Gln Gln Leu Tyr 
145                 150                 155                 160 


<210>  11
<211>  2354
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  11

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Gln Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Lys Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Ala Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn 
    370                 375                 380                 


Ser Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu 
            420                 425                 430         


Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Arg Pro Leu His Ser Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Leu Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Arg Asn Thr Gly 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Ser Thr Tyr Leu Leu Ser 
            740                 745                 750         


Glu Asn Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
        755                 760                 765             


Pro Ser Thr Arg Gln Lys Gln Phe Lys Ala Thr Thr Ile Pro Glu Asn 
    770                 775                 780                 


Asp Ile Glu Lys Ile Asp Pro Gln Phe Gly Glu Arg Thr Gln Met Leu 
785                 790                 795                 800 


Lys Val Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Thr 
            820                 825                 830         


Tyr Glu Ala Ile Pro Asp Asp His Ser Pro Gly Ala Ile Asp Ser Asn 
        835                 840                 845             


Glu Gly Pro Ser Glu Val Ala His Leu Arg Pro Glu Leu His His Ser 
    850                 855                 860                 


Gly Asp Met Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Leu Asn 
865                 870                 875                 880 


Glu Asn Leu Gly Thr Thr Ile Ala Val Glu Leu Lys Lys Leu Asp Leu 
                885                 890                 895     


Lys Val Ser Ser Ser Ser Asn Asn Leu Met Thr Ser Pro Thr Ile Pro 
            900                 905                 910         


Ser Asp Asn Leu Ala Ala Gly Thr Glu Lys Thr Gly Ser Leu Gly Pro 
        915                 920                 925             


Pro Asn Met Pro Val His Phe Asp Ser Gln Leu Asp Thr Thr Val Phe 
    930                 935                 940                 


Gly Lys Lys Ser Ser Pro Leu Ile Gly Ser Gly Val Pro Leu Ser Leu 
945                 950                 955                 960 


Ser Glu Arg Asn Asn Asp Ser Lys Leu Leu Glu Ala Ala Leu Met Asn 
                965                 970                 975     


Ser Gln Glu Ser Ser Leu Gly Lys Asn Val Ser Ser Met Glu Ser Asp 
            980                 985                 990         


Arg Leu Phe Lys Glu Lys Arg Ala  His Gly Pro Ala Leu  Leu Thr Lys 
        995                 1000                 1005             


Asp Asn  Ala Leu Phe Lys Val  Asn Ile Ser Leu Val  Lys Thr Asn 
    1010                 1015                 1020             


Lys Thr  Ser Asn Asn Ser Thr  Thr Asn Arg Lys Thr  His Ile Asp 
    1025                 1030                 1035             


Gly Pro  Thr Leu Leu Ile Glu  Asn Ser Thr Ser Val  Trp Gln Asp 
    1040                 1045                 1050             


Ile Leu  Glu Ser Asp Thr Glu  Phe Gln Glu Val Thr  Ser Leu Ile 
    1055                 1060                 1065             


His Asp  Lys Met Leu Met Asp  Lys Asn Thr Thr Ala  Leu Arg Leu 
    1070                 1075                 1080             


Asn His  Val Ser Asn Lys Thr  Thr Ser Ser Lys Asn  Met Glu Met 
    1085                 1090                 1095             


Val His  Gln Lys Lys Glu Gly  Pro Val Pro Pro Asp  Ala Glu Asn 
    1100                 1105                 1110             


Pro Asp  Met Ser Phe Phe Lys  Met Leu Phe Leu Pro  Glu Ser Ala 
    1115                 1120                 1125             


Asn Trp  Ile Lys Arg Thr His  Gly Lys Asn Ser Leu  Asn Ser Gly 
    1130                 1135                 1140             


Gln Gly  Pro Ser Pro Lys Gln  Leu Ile Ser Leu Gly  Ser Glu Lys 
    1145                 1150                 1155             


Ser Val  Lys Asp Gln Asn Phe  Leu Ser Glu Lys Asn  Lys Val Val 
    1160                 1165                 1170             


Val Gly  Glu Asp Glu Phe Thr  Lys Asp Thr Gly Leu  Lys Glu Met 
    1175                 1180                 1185             


Ile Phe  Pro Ser Ser Arg Asn  Ile Phe Leu Thr Asn  Leu Ala Asn 
    1190                 1195                 1200             


Val His  Glu Asn Asp Thr His  Asn Gln Glu Lys Lys  Ile Gln Glu 
    1205                 1210                 1215             


Glu Ile  Glu Arg Lys Glu Thr  Leu Ile Gln Glu Asn  Val Val Leu 
    1220                 1225                 1230             


Pro Gln  Val Tyr Thr Val Thr  Gly Thr Lys Asn Phe  Met Lys Asn 
    1235                 1240                 1245             


Leu Phe  Leu Leu Ser Thr Arg  Gln Asn Val Glu Gly  Leu Asp Glu 
    1250                 1255                 1260             


Gly Ala  Tyr Ala Pro Val Leu  Gln Asp Thr Arg Ser  Leu Asn Asp 
    1265                 1270                 1275             


Ser Thr  Asn Arg Thr Glu Ile  His Met Ala His Phe  Ser Lys Lys 
    1280                 1285                 1290             


Arg Glu  Glu Glu Asn Leu Glu  Gly Leu Gly Asn Gln  Thr Lys Gln 
    1295                 1300                 1305             


Met Val  Glu Lys Tyr Pro Ser  Thr Thr Arg Met Ser  Pro Asn Pro 
    1310                 1315                 1320             


Ser Gln  Gln Asn Val Ile Thr  Gln Arg Gly Lys Arg  Ala Leu Lys 
    1325                 1330                 1335             


Gln Phe  Arg Leu Pro Leu Glu  Glu Thr Glu Leu Glu  Lys Gly Leu 
    1340                 1345                 1350             


Ile Val  Asp Asp Thr Ser Thr  Gln Trp Ser Lys Asn  Met Lys Tyr 
    1355                 1360                 1365             


Leu Thr  Gln Ser Thr Leu Thr  Gln Ile Asp Tyr Asn  Glu Lys Glu 
    1370                 1375                 1380             


Lys Lys  Ala Ile Thr Gln Ser  Pro Leu Ser Asp Cys  Leu Met Arg 
    1385                 1390                 1395             


Asn His  Ser Ile Thr Gln Thr  Asn Ser Ser Ala Leu  Pro Ile Ala 
    1400                 1405                 1410             


Lys Val  Ser Ala Phe Pro Ser  Ile Arg Pro Thr Asp  Leu Thr Arg 
    1415                 1420                 1425             


Val Pro  Ser Gln Asp Asn Ser  Ser His Leu Leu Ala  Ser Ala Tyr 
    1430                 1435                 1440             


Arg Lys  Lys Ser Ser Gly Val  Gln Glu Ser Ser His  Phe Leu Gln 
    1445                 1450                 1455             


Gly Ala  Lys Arg Asn Asn Leu  Ser Leu Ala Ile Leu  Thr Leu Glu 
    1460                 1465                 1470             


Met Ile  Gly Asn Gln Arg Lys  Val Gly Ser Leu Gly  Thr Ser Ala 
    1475                 1480                 1485             


Thr Asn  Ser Val Met Tyr Lys  Lys Leu Glu Asn Thr  Val Leu Leu 
    1490                 1495                 1500             


Lys Pro  Gly Leu Pro Glu Ala  Ser Gly Lys Val Glu  Leu Leu Pro 
    1505                 1510                 1515             


Lys Val  His Ile His Gln Lys  Asp Leu Phe Pro Thr  Glu Thr Ser 
    1520                 1525                 1530             


Asn Gly  Ser Pro Gly His Leu  Asp Leu Met Glu Glu  Ile Leu Leu 
    1535                 1540                 1545             


Gln Lys  Thr Gln Gly Ala Ile  Lys Trp Asn Lys Thr  Asn Arg Pro 
    1550                 1555                 1560             


Gly Lys  Val Pro Phe Leu Lys  Gly Ala Thr Glu Ser  Ser Glu Lys 
    1565                 1570                 1575             


Thr Pro  Ser Lys Leu Leu Gly  Pro Leu Ala Trp Asp  Asn Gln Tyr 
    1580                 1585                 1590             


Ala Thr  Gln Ile Pro Lys Glu  Glu Trp Lys Ser Gln  Glu Lys Ser 
    1595                 1600                 1605             


Pro Glu  Asn Thr Ala Phe Lys  Thr Lys Asp Thr Ile  Leu Ser Leu 
    1610                 1615                 1620             


Asn Pro  Cys Glu Ser Asn His  Ala Ile Ala Ala Ile  Asn Glu Gly 
    1625                 1630                 1635             


Gln Asp  Arg Pro Gln Arg Glu  Ala Thr Trp Ala Lys  Gln Gly Gly 
    1640                 1645                 1650             


Thr Gly  Arg Leu Cys Ser Gln  Asn Pro Pro Val Leu  Lys Arg His 
    1655                 1660                 1665             


Gln Arg  Glu Ile Thr Leu Thr  Thr Leu Gln Ser Asp  Gln Glu Glu 
    1670                 1675                 1680             


Ile Asp  Tyr Asp Asp Thr Ile  Ser Ile Glu Thr Lys  Arg Glu Asp 
    1685                 1690                 1695             


Phe Asp  Ile Tyr Gly Glu Asp  Glu Asn Gln Ser Pro  Arg Ser Phe 
    1700                 1705                 1710             


Gln Lys  Lys Thr Arg His Tyr  Phe Ile Ala Ala Val  Glu Arg Leu 
    1715                 1720                 1725             


Trp Asp  Tyr Gly Met Ser Arg  Ser Pro His Val Leu  Arg Asn Arg 
    1730                 1735                 1740             


Ala Gln  Ser Gly Ser Val Pro  Gln Phe Lys Lys Val  Val Phe Gln 
    1745                 1750                 1755             


Glu Phe  Thr Asp Gly Ser Phe  Thr Gln Pro Leu Tyr  Arg Gly Glu 
    1760                 1765                 1770             


Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro Tyr Ile  Arg Ala Glu 
    1775                 1780                 1785             


Val Glu  Asp Asn Ile Met Val  Thr Phe Lys Asn Gln  Ala Ser Arg 
    1790                 1795                 1800             


Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser Tyr Glu  Glu Asp Gln 
    1805                 1810                 1815             


Arg Gln  Gly Ala Glu Pro Arg  Lys Asn Phe Val Lys  Pro Asn Glu 
    1820                 1825                 1830             


Thr Lys  Thr Tyr Phe Trp Lys  Val Gln His His Met  Ala Pro Thr 
    1835                 1840                 1845             


Lys Asp  Glu Phe Asp Cys Lys  Ala Trp Ala Tyr Phe  Ser Asp Val 
    1850                 1855                 1860             


Asp Leu  Glu Lys Asp Met His  Ser Gly Leu Ile Gly  Pro Leu Leu 
    1865                 1870                 1875             


Ile Cys  His Thr Asn Thr Leu  Asn Pro Ala His Gly  Arg Gln Val 
    1880                 1885                 1890             


Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr Ile Phe  Asp Glu Thr 
    1895                 1900                 1905             


Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu Arg Asn  Cys Arg Ala 
    1910                 1915                 1920             


Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr Phe Lys  Glu Asn Tyr 
    1925                 1930                 1935             


Arg Phe  His Ala Ile Asn Gly  Tyr Val Met Asp Thr  Leu Pro Gly 
    1940                 1945                 1950             


Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg Trp Tyr  Leu Leu Ser 
    1955                 1960                 1965             


Met Gly  Ser Asn Glu Asn Ile  His Ser Ile His Phe  Ser Gly His 
    1970                 1975                 1980             


Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr Lys Met  Ala Val Tyr 
    1985                 1990                 1995             


Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val Glu Met  Leu Pro Ser 
    2000                 2005                 2010             


Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu Ile Gly  Glu His Leu 
    2015                 2020                 2025             


His Ala  Gly Met Ser Thr Leu  Phe Leu Val Tyr Ser  Lys Gln Cys 
    2030                 2035                 2040             


Gln Thr  Pro Leu Gly Met Ala  Ser Gly His Ile Arg  Asp Phe Gln 
    2045                 2050                 2055             


Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp Ala Pro  Lys Leu Ala 
    2060                 2065                 2070             


Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala Trp Ser  Thr Lys Glu 
    2075                 2080                 2085             


Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu Ala Pro  Met Ile Ile 
    2090                 2095                 2100             


His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln Lys Phe  Ser Ser Leu 
    2105                 2110                 2115             


Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser Leu Asp  Gly Lys Lys 
    2120                 2125                 2130             


Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly Thr Leu  Met Val Phe 
    2135                 2140                 2145             


Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys His Asn  Ile Phe Asn 
    2150                 2155                 2160             


Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu His Pro  Thr His Tyr 
    2165                 2170                 2175             


Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu Met Gly  Cys Asp Leu 
    2180                 2185                 2190             


Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu Ser Lys  Ala Ile Ser 
    2195                 2200                 2205             


Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe Thr Asn  Met Phe Ala 
    2210                 2215                 2220             


Thr Trp  Ser Pro Ser Gln Ala  Arg Leu His Leu Gln  Gly Arg Thr 
    2225                 2230                 2235             


Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro Lys Glu  Trp Leu Gln 
    2240                 2245                 2250             


Val Asp  Phe Gln Lys Thr Met  Lys Val Thr Gly Ile  Thr Thr Gln 
    2255                 2260                 2265             


Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr Val Lys  Glu Phe Leu 
    2270                 2275                 2280             


Ile Ser  Ser Ser Gln Asp Gly  His His Trp Thr Leu  Phe Phe Gln 
    2285                 2290                 2295             


Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn Gln Asp  Ser Phe Thr 
    2300                 2305                 2310             


Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu Leu Thr  Arg Tyr Leu 
    2315                 2320                 2325             


Arg Ile  His Pro Gln Ser Trp  Val His Gln Ile Ala  Leu Arg Leu 
    2330                 2335                 2340             


Glu Val  Leu Gly Cys Glu Ala  Gln Gln Leu Tyr 
    2345                 2350                 


<210>  12
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  12

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Gln Phe 
1               5                   10                  15      


Ser Phe Ser 
            


<210>  13
<211>  374
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  13

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr Arg Phe Pro 
            20                  25                  30          


Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val Met Tyr Lys 
        35                  40                  45              


Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys 
    50                  55                  60                  


Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln Ala Glu 
65                  70                  75                  80  


Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro 
                85                  90                  95      


Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly 
            100                 105                 110         


Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys 
        115                 120                 125             


Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu 
    130                 135                 140                 


Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr Ser Tyr Leu 
145                 150                 155                 160 


Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala 
                165                 170                 175     


Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg Thr Gln Thr 
            180                 185                 190         


Leu His Lys Phe Val Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser 
        195                 200                 205             


Trp His Ser Glu Thr Lys Asp Ser Leu Met Gln Asp Met Asp Ser Ala 
    210                 215                 220                 


Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn 
225                 230                 235                 240 


Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp 
                245                 250                 255     


His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu 
            260                 265                 270         


Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu 
        275                 280                 285             


Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu 
    290                 295                 300                 


Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly 
305                 310                 315                 320 


Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu 
                325                 330                 335     


Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp Asp Leu Ala 
            340                 345                 350         


Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Ser 
        355                 360                 365             


Phe Ile Gln Ile Arg Ser 
    370                 


<210>  14
<211>  367
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  14

Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu 
1               5                   10                  15      


Glu Glu Asp Trp Asp Tyr Ala Pro Ser Val Leu Thr Pro Asp Asp Arg 
            20                  25                  30          


Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg 
        35                  40                  45              


Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys 
    50                  55                  60                  


Thr Arg Glu Ala Ile Gln Tyr Glu Ser Gly Ile Leu Gly Pro Leu Leu 
65                  70                  75                  80  


Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala 
                85                  90                  95      


Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Arg Pro 
            100                 105                 110         


Leu His Ser Gly Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Leu 
        115                 120                 125             


Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val 
    130                 135                 140                 


Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr 
145                 150                 155                 160 


Ser Ser Phe Ile Asn Leu Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly 
                165                 170                 175     


Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln 
            180                 185                 190         


Met Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu 
        195                 200                 205             


Asn Arg Ser Trp Tyr Leu Thr Glu Asn Met Gln Arg Phe Leu Pro Asn 
    210                 215                 220                 


Ala Ala Gly Val Gln Pro Gln Asp Pro Glu Phe Gln Ala Ser Asn Ile 
225                 230                 235                 240 


Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val 
                245                 250                 255     


Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Ile Gly Ala Gln 
            260                 265                 270         


Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys 
        275                 280                 285             


Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr 
    290                 295                 300                 


Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Val Leu Gly Cys His 
305                 310                 315                 320 


Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser 
                325                 330                 335     


Ser Cys Asp Arg Asn Thr Gly Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp 
            340                 345                 350         


Ile Ser Thr Tyr Leu Leu Ser Glu Asn Asn Val Ile Glu Pro Arg 
        355                 360                 365         


<210>  15
<211>  910
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  15

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Lys Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Ile Asp Pro Gln 
            20                  25                  30          


Phe Gly Glu Arg Thr Gln Met Leu Lys Val Gln Ser Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Gly Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Thr Tyr Glu Ala Ile Pro Asp Asp His 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Glu Gly Pro Ser Glu Val Ala His 
                85                  90                  95      


Leu Arg Pro Glu Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Pro Gly Leu Gln Leu Arg Leu Asn Glu Asn Leu Gly Thr Thr Ile Ala 
        115                 120                 125             


Val Glu Leu Lys Lys Leu Asp Leu Lys Val Ser Ser Ser Ser Asn Asn 
    130                 135                 140                 


Leu Met Thr Ser Pro Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr 
145                 150                 155                 160 


Glu Lys Thr Gly Ser Leu Gly Pro Pro Asn Met Pro Val His Phe Asp 
                165                 170                 175     


Ser Gln Leu Asp Thr Thr Val Phe Gly Lys Lys Ser Ser Pro Leu Ile 
            180                 185                 190         


Gly Ser Gly Val Pro Leu Ser Leu Ser Glu Arg Asn Asn Asp Ser Lys 
        195                 200                 205             


Leu Leu Glu Ala Ala Leu Met Asn Ser Gln Glu Ser Ser Leu Gly Lys 
    210                 215                 220                 


Asn Val Ser Ser Met Glu Ser Asp Arg Leu Phe Lys Glu Lys Arg Ala 
225                 230                 235                 240 


His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Asn 
                245                 250                 255     


Ile Ser Leu Val Lys Thr Asn Lys Thr Ser Asn Asn Ser Thr Thr Asn 
            260                 265                 270         


Arg Lys Thr His Ile Asp Gly Pro Thr Leu Leu Ile Glu Asn Ser Thr 
        275                 280                 285             


Ser Val Trp Gln Asp Ile Leu Glu Ser Asp Thr Glu Phe Gln Glu Val 
    290                 295                 300                 


Thr Ser Leu Ile His Asp Lys Met Leu Met Asp Lys Asn Thr Thr Ala 
305                 310                 315                 320 


Leu Arg Leu Asn His Val Ser Asn Lys Thr Thr Ser Ser Lys Asn Met 
                325                 330                 335     


Glu Met Val His Gln Lys Lys Glu Gly Pro Val Pro Pro Asp Ala Glu 
            340                 345                 350         


Asn Pro Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser Ala 
        355                 360                 365             


Asn Trp Ile Lys Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly Gln 
    370                 375                 380                 


Gly Pro Ser Pro Lys Gln Leu Ile Ser Leu Gly Ser Glu Lys Ser Val 
385                 390                 395                 400 


Lys Asp Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly Glu 
                405                 410                 415     


Asp Glu Phe Thr Lys Asp Thr Gly Leu Lys Glu Met Ile Phe Pro Ser 
            420                 425                 430         


Ser Arg Asn Ile Phe Leu Thr Asn Leu Ala Asn Val His Glu Asn Asp 
        435                 440                 445             


Thr His Asn Gln Glu Lys Lys Ile Gln Glu Glu Ile Glu Arg Lys Glu 
    450                 455                 460                 


Thr Leu Ile Gln Glu Asn Val Val Leu Pro Gln Val Tyr Thr Val Thr 
465                 470                 475                 480 


Gly Thr Lys Asn Phe Met Lys Asn Leu Phe Leu Leu Ser Thr Arg Gln 
                485                 490                 495     


Asn Val Glu Gly Leu Asp Glu Gly Ala Tyr Ala Pro Val Leu Gln Asp 
            500                 505                 510         


Thr Arg Ser Leu Asn Asp Ser Thr Asn Arg Thr Glu Ile His Met Ala 
        515                 520                 525             


His Phe Ser Lys Lys Arg Glu Glu Glu Asn Leu Glu Gly Leu Gly Asn 
    530                 535                 540                 


Gln Thr Lys Gln Met Val Glu Lys Tyr Pro Ser Thr Thr Arg Met Ser 
545                 550                 555                 560 


Pro Asn Pro Ser Gln Gln Asn Val Ile Thr Gln Arg Gly Lys Arg Ala 
                565                 570                 575     


Leu Lys Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys Gly 
            580                 585                 590         


Leu Ile Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys Tyr 
        595                 600                 605             


Leu Thr Gln Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu Lys 
    610                 615                 620                 


Lys Ala Ile Thr Gln Ser Pro Leu Ser Asp Cys Leu Met Arg Asn His 
625                 630                 635                 640 


Ser Ile Thr Gln Thr Asn Ser Ser Ala Leu Pro Ile Ala Lys Val Ser 
                645                 650                 655     


Ala Phe Pro Ser Ile Arg Pro Thr Asp Leu Thr Arg Val Pro Ser Gln 
            660                 665                 670         


Asp Asn Ser Ser His Leu Leu Ala Ser Ala Tyr Arg Lys Lys Ser Ser 
        675                 680                 685             


Gly Val Gln Glu Ser Ser His Phe Leu Gln Gly Ala Lys Arg Asn Asn 
    690                 695                 700                 


Leu Ser Leu Ala Ile Leu Thr Leu Glu Met Ile Gly Asn Gln Arg Lys 
705                 710                 715                 720 


Val Gly Ser Leu Gly Thr Ser Ala Thr Asn Ser Val Met Tyr Lys Lys 
                725                 730                 735     


Leu Glu Asn Thr Val Leu Leu Lys Pro Gly Leu Pro Glu Ala Ser Gly 
            740                 745                 750         


Lys Val Glu Leu Leu Pro Lys Val His Ile His Gln Lys Asp Leu Phe 
        755                 760                 765             


Pro Thr Glu Thr Ser Asn Gly Ser Pro Gly His Leu Asp Leu Met Glu 
    770                 775                 780                 


Glu Ile Leu Leu Gln Lys Thr Gln Gly Ala Ile Lys Trp Asn Lys Thr 
785                 790                 795                 800 


Asn Arg Pro Gly Lys Val Pro Phe Leu Lys Gly Ala Thr Glu Ser Ser 
                805                 810                 815     


Glu Lys Thr Pro Ser Lys Leu Leu Gly Pro Leu Ala Trp Asp Asn Gln 
            820                 825                 830         


Tyr Ala Thr Gln Ile Pro Lys Glu Glu Trp Lys Ser Gln Glu Lys Ser 
        835                 840                 845             


Pro Glu Asn Thr Ala Phe Lys Thr Lys Asp Thr Ile Leu Ser Leu Asn 
    850                 855                 860                 


Pro Cys Glu Ser Asn His Ala Ile Ala Ala Ile Asn Glu Gly Gln Asp 
865                 870                 875                 880 


Arg Pro Gln Arg Glu Ala Thr Trp Ala Lys Gln Gly Gly Thr Gly Arg 
                885                 890                 895     


Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg His Gln Arg 
            900                 905                 910 


<210>  16
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  16

Glu Ile Thr Leu Thr Thr Leu Gln Ser Asp Gln Glu Glu Ile Asp Tyr 
1               5                   10                  15      


Asp Asp Thr Ile Ser Ile Glu Thr Lys Arg Glu Asp Phe Asp Ile Tyr 
            20                  25                  30          


Gly Glu Asp Glu Asn Gln Ser Pro Arg 
        35                  40      


<210>  17
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  17

Ser Phe Gln Lys Lys Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg 
1               5                   10                  15      


Leu Trp Asp Tyr Gly Met Ser Arg Ser Pro His Val Leu Arg Asn Arg 
            20                  25                  30          


Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu 
        35                  40                  45              


Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn 
    50                  55                  60                  


Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp 
65                  70                  75                  80  


Asn Ile Met Val Thr Phe Lys Asn Gln Ala Ser Arg Pro Tyr Ser Phe 
                85                  90                  95      


Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu 
            100                 105                 110         


Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp 
        115                 120                 125             


Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys 
    130                 135                 140                 


Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Met His Ser 
145                 150                 155                 160 


Gly Leu Ile Gly Pro Leu Leu Ile Cys His Thr Asn Thr Leu Asn Pro 
                165                 170                 175     


Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr 
            180                 185                 190         


Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg 
        195                 200                 205             


Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys 
    210                 215                 220                 


Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Val Met Asp Thr Leu 
225                 230                 235                 240 


Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu 
                245                 250                 255     


Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His 
            260                 265                 270         


Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Val Tyr Asn 
        275                 280                 285             


Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala 
    290                 295                 300                 


Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly 
305                 310                 315                 320 


Met Ser Thr Leu Phe Leu Val Tyr Ser Lys 
                325                 330 


<210>  18
<211>  153
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  18

Gln Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe 
1               5                   10                  15      


Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala 
            20                  25                  30          


Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro 
        35                  40                  45              


Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly 
    50                  55                  60                  


Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser 
65                  70                  75                  80  


Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr 
                85                  90                  95      


Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp 
            100                 105                 110         


Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg 
        115                 120                 125             


Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg 
    130                 135                 140                 


Met Glu Leu Met Gly Cys Asp Leu Asn 
145                 150             


<210>  19
<211>  160
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  19

Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala 
1               5                   10                  15      


Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser 
            20                  25                  30          


Pro Ser Gln Ala Arg Leu His Leu Gln Gly Arg Thr Asn Ala Trp Arg 
        35                  40                  45              


Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys 
    50                  55                  60                  


Thr Met Lys Val Thr Gly Ile Thr Thr Gln Gly Val Lys Ser Leu Leu 
65                  70                  75                  80  


Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly 
                85                  90                  95      


His His Trp Thr Leu Phe Phe Gln Asn Gly Lys Val Lys Val Phe Gln 
            100                 105                 110         


Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro 
        115                 120                 125             


Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln 
    130                 135                 140                 


Ile Ala Leu Arg Leu Glu Val Leu Gly Cys Glu Ala Gln Gln Leu Tyr 
145                 150                 155                 160 


<210>  20
<211>  2359
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  20

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Gln Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Arg Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Tyr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn 
    370                 375                 380                 


Ser Pro Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu 
            420                 425                 430         


Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Ser Pro Leu His Ser Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Leu Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Arg Asn Thr Gly 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Pro Thr Tyr Leu Leu Ser 
            740                 745                 750         


Glu Asn Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
        755                 760                 765             


Pro Ser Thr Arg Gln Lys Gln Phe Lys Ala Thr Thr Ile Pro Glu Asn 
    770                 775                 780                 


Asp Ile Glu Lys Ile Asp Pro Gln Phe Gly Glu Arg Thr Gln Met Leu 
785                 790                 795                 800 


Lys Val Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Thr 
            820                 825                 830         


Tyr Glu Ala Ile Pro Asp Asp His Ser Pro Gly Ala Ile Asp Ser Asn 
        835                 840                 845             


Glu Gly Pro Ser Glu Val Ala His Leu Arg Pro Glu Leu His His Ser 
    850                 855                 860                 


Gly Asp Met Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Leu Asn 
865                 870                 875                 880 


Glu Asn Leu Gly Thr Thr Ile Ala Val Glu Leu Lys Lys Leu Asp Leu 
                885                 890                 895     


Lys Val Ser Ser Ser Ser Asn Asn Leu Met Thr Ser Pro Thr Ile Pro 
            900                 905                 910         


Ser Asp Asn Leu Ala Ala Gly Thr Glu Lys Thr Gly Ser Leu Gly Pro 
        915                 920                 925             


Pro Asn Met Pro Val His Phe Ser Ser Gln Leu Gly Thr Thr Val Phe 
    930                 935                 940                 


Gly Lys Lys Ser Ser Pro Leu Ile Gly Ser Gly Val Pro Leu Asn Leu 
945                 950                 955                 960 


Ser Glu Arg Asn Asn Asp Ser Lys Leu Leu Glu Ala Ala Leu Met Asn 
                965                 970                 975     


Ser Gln Glu Ser Ser Leu Gly Lys Asn Val Ser Ser Met Glu Ser Asp 
            980                 985                 990         


Arg Leu Phe Lys Glu Lys Arg Val  His Gly Pro Ala Leu  Leu Thr Lys 
        995                 1000                 1005             


Asp Asn  Ala Leu Phe Lys Val  Asn Ile Ser Leu Val  Lys Thr Asn 
    1010                 1015                 1020             


Lys Thr  Ser Asn Asn Ser Thr  Thr Asn Arg Lys Thr  His Ile Asp 
    1025                 1030                 1035             


Gly Pro  Thr Leu Leu Ile Glu  Asn Ser Thr Ser Val  Trp Gln Asp 
    1040                 1045                 1050             


Ile Ile  Leu Glu Ser Asp Thr  Glu Phe Gln Glu Val  Thr Ser Leu 
    1055                 1060                 1065             


Ile His  Asp Glu Met Leu Met  Asp Lys Asn Thr Thr  Ala Leu Arg 
    1070                 1075                 1080             


Leu Asn  His Val Ser Asn Lys  Thr Thr Ser Ser Lys  Asn Met Glu 
    1085                 1090                 1095             


Met Val  His Gln Lys Lys Glu  Gly Pro Val Pro Pro  Asp Ala Glu 
    1100                 1105                 1110             


Asn Pro  Asp Met Ser Phe Phe  Lys Met Leu Phe Leu  Pro Glu Ser 
    1115                 1120                 1125             


Ala Asn  Trp Ile Lys Arg Thr  His Gly Lys Asn Ser  Leu Asn Ser 
    1130                 1135                 1140             


Gly Gln  Gly Pro Ser Pro Lys  Gln Leu Ile Ser Leu  Gly Ser Glu 
    1145                 1150                 1155             


Lys Ser  Val Lys Asp Gln Asn  Phe Leu Ser Glu Lys  Asn Lys Val 
    1160                 1165                 1170             


Val Val  Gly Glu Asp Glu Phe  Thr Lys Asp Thr Gly  Leu Lys Glu 
    1175                 1180                 1185             


Met Ile  Phe Pro Asn Ser Arg  Ser Ile Phe Leu Thr  Asn Leu Ala 
    1190                 1195                 1200             


Asn Val  Gln Glu Asn Asp Thr  His Asn Gln Glu Lys  Lys Phe Gln 
    1205                 1210                 1215             


Glu Glu  Ile Glu Arg Lys Glu  Thr Leu Ile Gln Glu  Asn Val Val 
    1220                 1225                 1230             


Leu Pro  Gln Val Tyr Thr Val  Thr Gly Thr Lys Asn  Phe Leu Lys 
    1235                 1240                 1245             


Asn Leu  Phe Leu Leu Ser Thr  Arg Gln Asn Val Glu  Gly Leu Asp 
    1250                 1255                 1260             


Glu Gly  Thr Tyr Ala Pro Val  Leu Gln Asp Thr Arg  Ser Leu Asn 
    1265                 1270                 1275             


Asp Ser  Thr Asn Arg Ala Glu  Ile His Met Ala His  Phe Ser Lys 
    1280                 1285                 1290             


Arg Arg  Glu Glu Glu Asn Leu  Glu Gly Leu Gly Asn  Gln Thr Lys 
    1295                 1300                 1305             


Gln Met  Val Glu Lys Tyr Pro  Ser Thr Thr Arg Met  Ser Pro Asn 
    1310                 1315                 1320             


Pro Ser  Gln Gln Asn Val Ile  Thr Gln Arg Gly Lys  Arg Ala Leu 
    1325                 1330                 1335             


Lys Gln  Phe Arg Leu Pro Leu  Glu Glu Thr Glu Leu  Glu Lys Gly 
    1340                 1345                 1350             


Leu Ile  Val Asp Asp Thr Ser  Thr Gln Trp Ser Lys  Asn Met Lys 
    1355                 1360                 1365             


Tyr Leu  Thr Gln Ser Thr Leu  Thr Gln Ile Asp Tyr  Asn Glu Lys 
    1370                 1375                 1380             


Glu Lys  Lys Ala Ile Thr Gln  Ser Pro Leu Ser Asp  Cys Ser Met 
    1385                 1390                 1395             


Arg Asn  His Ser Ile Thr Gln  Thr Asn Ser Ser Ala  Leu Pro Ile 
    1400                 1405                 1410             


Ala Lys  Val Ser Ala Phe Pro  Ser Ile Arg Pro Thr  Asp Leu Thr 
    1415                 1420                 1425             


Lys Ile  Pro Ser Gln Asp Asn  Ser Ser His Leu Leu  Ala Ser Ala 
    1430                 1435                 1440             


Tyr Ser  Tyr Thr Phe Arg Glu  Lys Ser Ser Gly Val  Gln Glu Ser 
    1445                 1450                 1455             


Ser His  Phe Leu Gln Gly Ala  Lys Arg Asn Asn Leu  Ser Leu Ala 
    1460                 1465                 1470             


Ile Leu  Thr Leu Glu Met Ile  Arg Asn Gln Glu Lys  Val Gly Ser 
    1475                 1480                 1485             


Leu Gly  Thr Ser Ala Thr Asn  Ser Val Met Tyr Lys  Lys Leu Glu 
    1490                 1495                 1500             


Asn Thr  Val Leu Leu Lys Pro  Gly Leu Pro Glu Ala  Ser Gly Lys 
    1505                 1510                 1515             


Val Glu  Leu Leu Pro Lys Val  His Ile His Gln Glu  Asp Leu Phe 
    1520                 1525                 1530             


Pro Thr  Glu Thr Ser Asn Gly  Ser Pro Gly His Leu  Asp Leu Met 
    1535                 1540                 1545             


Glu Glu  Ile Leu Leu Gln Lys  Thr Gln Gly Ala Ile  Lys Trp Asn 
    1550                 1555                 1560             


Lys Thr  Asn Arg Pro Gly Lys  Val Pro Phe Leu Lys  Gly Ala Thr 
    1565                 1570                 1575             


Glu Ser  Ser Glu Lys Thr Pro  Ser Lys Leu Leu Gly  Pro Leu Ala 
    1580                 1585                 1590             


Trp Asp  Asn Gln Tyr Ala Thr  Gln Ile Pro Lys Glu  Glu Trp Lys 
    1595                 1600                 1605             


Ser Gln  Glu Lys Ser Pro Lys  Asn Thr Ala Phe Lys  Thr Lys Asp 
    1610                 1615                 1620             


Thr Ile  Leu Ser Leu Asn Pro  Cys Glu Asn Asn His  Ala Ile Ala 
    1625                 1630                 1635             


Ala Ile  Asn Glu Gly Gln Asp  Arg Pro Gln Arg Glu  Ala Thr Trp 
    1640                 1645                 1650             


Ala Lys  Gln Gly Gly Thr Gly  Arg Leu Cys Ser Gln  Asn Pro Pro 
    1655                 1660                 1665             


Val Leu  Lys Arg His Gln Arg  Glu Ile Thr Leu Thr  Thr Leu Gln 
    1670                 1675                 1680             


Ser Glu  Gln Glu Glu Ile Asp  Tyr Asp Asp Thr Ile  Ser Ile Glu 
    1685                 1690                 1695             


Thr Lys  Arg Glu Asp Phe Asp  Ile Tyr Gly Glu Asp  Glu Asn Gln 
    1700                 1705                 1710             


Gly Pro  Arg Ser Phe Gln Lys  Arg Thr Arg His Tyr  Phe Ile Ala 
    1715                 1720                 1725             


Ala Val  Glu Arg Leu Trp Asp  Tyr Gly Met Ser Arg  Ser Pro His 
    1730                 1735                 1740             


Val Leu  Arg Asn Arg Ala Gln  Ser Gly Ser Val Pro  Gln Phe Lys 
    1745                 1750                 1755             


Lys Val  Val Phe Gln Glu Phe  Thr Asp Gly Ser Phe  Thr Gln Pro 
    1760                 1765                 1770             


Leu Tyr  Arg Gly Glu Leu Asn  Glu His Leu Gly Leu  Leu Gly Pro 
    1775                 1780                 1785             


Tyr Ile  Arg Ala Glu Val Glu  Asp Asn Ile Met Val  Thr Phe Lys 
    1790                 1795                 1800             


Asn Gln  Ala Ser Arg Pro Tyr  Ser Phe Tyr Ser Ser  Leu Ile Ser 
    1805                 1810                 1815             


Tyr Glu  Glu Asp Gln Arg Gln  Gly Ala Glu Pro Arg  Lys Asn Phe 
    1820                 1825                 1830             


Val Lys  Pro Asn Glu Thr Lys  Thr Tyr Phe Trp Lys  Val Gln His 
    1835                 1840                 1845             


His Met  Ala Pro Thr Lys Asp  Glu Phe Asp Cys Lys  Ala Trp Ala 
    1850                 1855                 1860             


Tyr Phe  Ser Asp Val Asp Leu  Glu Lys Asp Met His  Ser Gly Leu 
    1865                 1870                 1875             


Ile Gly  Pro Leu Leu Ile Cys  His Thr Asn Thr Leu  Asn Pro Ala 
    1880                 1885                 1890             


His Gly  Arg Gln Val Thr Val  Gln Glu Phe Ala Leu  Phe Phe Thr 
    1895                 1900                 1905             


Ile Phe  Asp Glu Thr Lys Ser  Trp Tyr Phe Thr Glu  Asn Met Glu 
    1910                 1915                 1920             


Arg Asn  Cys Arg Ala Pro Cys  Asn Ile Gln Met Glu  Asp Pro Thr 
    1925                 1930                 1935             


Phe Lys  Glu Asn Tyr Arg Phe  His Ala Ile Asn Gly  Tyr Val Met 
    1940                 1945                 1950             


Asp Thr  Leu Pro Gly Leu Val  Met Ala Gln Asp Gln  Arg Ile Arg 
    1955                 1960                 1965             


Trp Tyr  Leu Leu Ser Met Gly  Ser Asn Glu Asn Ile  His Ser Ile 
    1970                 1975                 1980             


His Phe  Ser Gly His Val Phe  Thr Val Arg Lys Lys  Glu Glu Tyr 
    1985                 1990                 1995             


Lys Met  Ala Val Tyr Asn Leu  Tyr Pro Gly Val Phe  Glu Thr Val 
    2000                 2005                 2010             


Glu Met  Leu Pro Ser Lys Ala  Gly Ile Trp Arg Val  Glu Cys Leu 
    2015                 2020                 2025             


Ile Gly  Glu His Leu His Ala  Gly Met Ser Thr Leu  Phe Leu Val 
    2030                 2035                 2040             


Tyr Ser  Lys Gln Cys Gln Thr  Pro Leu Gly Met Ala  Ser Gly His 
    2045                 2050                 2055             


Ile Arg  Asp Phe Gln Ile Thr  Ala Ser Gly Gln Tyr  Gly Gln Trp 
    2060                 2065                 2070             


Ala Pro  Lys Leu Ala Arg Leu  His Tyr Ser Gly Ser  Ile Asn Ala 
    2075                 2080                 2085             


Trp Ser  Thr Lys Glu Pro Phe  Ser Trp Ile Lys Val  Asp Leu Leu 
    2090                 2095                 2100             


Ala Pro  Met Ile Ile His Gly  Ile Lys Thr Gln Gly  Ala Arg Gln 
    2105                 2110                 2115             


Lys Phe  Ser Ser Leu Tyr Ile  Ser Gln Phe Ile Ile  Met Tyr Ser 
    2120                 2125                 2130             


Leu Asp  Gly Lys Lys Trp Gln  Thr Tyr Arg Gly Asn  Ser Thr Gly 
    2135                 2140                 2145             


Thr Leu  Met Val Phe Phe Gly  Asn Val Asp Ser Ser  Gly Ile Lys 
    2150                 2155                 2160             


His Asn  Ile Phe Asn Pro Pro  Ile Ile Ala Arg Tyr  Ile Arg Leu 
    2165                 2170                 2175             


His Pro  Thr His Tyr Ser Ile  Arg Ser Thr Leu Arg  Met Glu Leu 
    2180                 2185                 2190             


Met Gly  Cys Asp Leu Asn Ser  Cys Ser Met Pro Leu  Gly Met Glu 
    2195                 2200                 2205             


Ser Lys  Ala Ile Ser Asp Ala  Gln Ile Thr Ala Ser  Ser Tyr Phe 
    2210                 2215                 2220             


Thr Asn  Met Phe Ala Thr Trp  Ser Pro Ser Gln Ala  Arg Leu His 
    2225                 2230                 2235             


Leu Gln  Gly Arg Thr Asn Ala  Trp Arg Pro Gln Val  Asn Asn Pro 
    2240                 2245                 2250             


Lys Glu  Trp Leu Gln Val Asp  Phe Gln Lys Thr Met  Lys Val Thr 
    2255                 2260                 2265             


Gly Ile  Thr Thr Gln Gly Val  Lys Ser Leu Leu Thr  Ser Met Tyr 
    2270                 2275                 2280             


Val Lys  Glu Phe Leu Ile Ser  Ser Ser Gln Asp Gly  His His Trp 
    2285                 2290                 2295             


Thr Leu  Phe Leu Gln Asn Gly  Lys Val Lys Val Phe  Gln Gly Asn 
    2300                 2305                 2310             


Gln Asp  Ser Phe Thr Pro Val  Val Asn Ser Leu Asp  Pro Pro Leu 
    2315                 2320                 2325             


Leu Thr  Arg Tyr Leu Arg Ile  His Pro Gln Ser Trp  Val His Gln 
    2330                 2335                 2340             


Ile Ala  Leu Arg Leu Glu Val  Leu Gly Cys Glu Ala  Gln Gln Leu 
    2345                 2350                 2355             


Tyr 
    


<210>  21
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  21

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Gln Phe 
1               5                   10                  15      


Ser Phe Ser 
            


<210>  22
<211>  374
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  22

Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser Trp Asp Tyr 
1               5                   10                  15      


Met Gln Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr Arg Phe Pro 
            20                  25                  30          


Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val Met Tyr Lys 
        35                  40                  45              


Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile Ala Lys 
    50                  55                  60                  


Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Arg Ala Glu 
65                  70                  75                  80  


Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser His Pro 
                85                  90                  95      


Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser Glu Gly 
            100                 105                 110         


Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp Asp Lys 
        115                 120                 125             


Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val Leu Lys Glu 
    130                 135                 140                 


Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr Ser Tyr Leu 
145                 150                 155                 160 


Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile Gly Ala 
                165                 170                 175     


Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg Thr Gln Thr 
            180                 185                 190         


Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu Gly Lys Ser 
        195                 200                 205             


Trp His Ser Glu Thr Lys Asp Ser Leu Thr Gln Ala Met Asp Ser Ala 
    210                 215                 220                 


Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr Val Asn 
225                 230                 235                 240 


Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val Tyr Trp 
                245                 250                 255     


His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu 
            260                 265                 270         


Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu 
        275                 280                 285             


Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met Asp Leu 
    290                 295                 300                 


Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly 
305                 310                 315                 320 


Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu 
                325                 330                 335     


Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp Asp Leu Tyr 
            340                 345                 350         


Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser Pro Pro 
        355                 360                 365             


Phe Ile Gln Ile Arg Ser 
    370                 


<210>  23
<211>  367
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  23

Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr Ile Ala Ala Glu 
1               5                   10                  15      


Glu Glu Asp Trp Asp Tyr Ala Pro Ser Val Leu Thr Pro Asp Asp Arg 
            20                  25                  30          


Ser Tyr Lys Ser Gln Tyr Leu Asn Asn Gly Pro Gln Arg Ile Gly Arg 
        35                  40                  45              


Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp Glu Thr Phe Lys 
    50                  55                  60                  


Thr Arg Glu Ala Ile Gln Tyr Glu Ser Gly Ile Leu Gly Pro Leu Leu 
65                  70                  75                  80  


Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe Lys Asn Gln Ala 
                85                  90                  95      


Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr Asp Val Ser Pro 
            100                 105                 110         


Leu His Ser Gly Arg Leu Pro Lys Gly Val Lys His Leu Lys Asp Leu 
        115                 120                 125             


Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp Thr Val Thr Val 
    130                 135                 140                 


Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu Thr Arg Tyr Tyr 
145                 150                 155                 160 


Ser Ser Phe Ile Asn Leu Glu Arg Asp Leu Ala Ser Gly Leu Ile Gly 
                165                 170                 175     


Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln Arg Gly Asn Gln 
            180                 185                 190         


Met Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser Val Phe Asp Glu 
        195                 200                 205             


Asn Arg Ser Trp Tyr Leu Thr Glu Asn Met Gln Arg Phe Leu Pro Asn 
    210                 215                 220                 


Ala Ala Gly Val Gln Pro Gln Asp Pro Glu Phe Gln Ala Ser Asn Ile 
225                 230                 235                 240 


Met His Ser Ile Asn Gly Tyr Val Phe Asp Ser Leu Gln Leu Ser Val 
                245                 250                 255     


Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser Val Gly Ala Gln 
            260                 265                 270         


Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr Phe Lys His Lys 
        275                 280                 285             


Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe Ser Gly Glu Thr 
    290                 295                 300                 


Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Val Leu Gly Cys His 
305                 310                 315                 320 


Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu Leu Lys Val Ser 
                325                 330                 335     


Ser Cys Asp Arg Asn Thr Gly Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp 
            340                 345                 350         


Ile Pro Thr Tyr Leu Leu Ser Glu Asn Asn Val Ile Glu Pro Arg 
        355                 360                 365         


<210>  24
<211>  915
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  24

Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln Lys Gln Phe 
1               5                   10                  15      


Lys Ala Thr Thr Ile Pro Glu Asn Asp Ile Glu Lys Ile Asp Pro Gln 
            20                  25                  30          


Phe Gly Glu Arg Thr Gln Met Leu Lys Val Gln Ser Val Ser Ser Ser 
        35                  40                  45              


Asp Leu Leu Met Leu Leu Gly Gln Ser Pro Thr Pro His Gly Leu Ser 
    50                  55                  60                  


Leu Ser Asp Leu Gln Glu Ala Thr Tyr Glu Ala Ile Pro Asp Asp His 
65                  70                  75                  80  


Ser Pro Gly Ala Ile Asp Ser Asn Glu Gly Pro Ser Glu Val Ala His 
                85                  90                  95      


Leu Arg Pro Glu Leu His His Ser Gly Asp Met Val Phe Thr Pro Glu 
            100                 105                 110         


Pro Gly Leu Gln Leu Arg Leu Asn Glu Asn Leu Gly Thr Thr Ile Ala 
        115                 120                 125             


Val Glu Leu Lys Lys Leu Asp Leu Lys Val Ser Ser Ser Ser Asn Asn 
    130                 135                 140                 


Leu Met Thr Ser Pro Thr Ile Pro Ser Asp Asn Leu Ala Ala Gly Thr 
145                 150                 155                 160 


Glu Lys Thr Gly Ser Leu Gly Pro Pro Asn Met Pro Val His Phe Ser 
                165                 170                 175     


Ser Gln Leu Gly Thr Thr Val Phe Gly Lys Lys Ser Ser Pro Leu Ile 
            180                 185                 190         


Gly Ser Gly Val Pro Leu Asn Leu Ser Glu Arg Asn Asn Asp Ser Lys 
        195                 200                 205             


Leu Leu Glu Ala Ala Leu Met Asn Ser Gln Glu Ser Ser Leu Gly Lys 
    210                 215                 220                 


Asn Val Ser Ser Met Glu Ser Asp Arg Leu Phe Lys Glu Lys Arg Val 
225                 230                 235                 240 


His Gly Pro Ala Leu Leu Thr Lys Asp Asn Ala Leu Phe Lys Val Asn 
                245                 250                 255     


Ile Ser Leu Val Lys Thr Asn Lys Thr Ser Asn Asn Ser Thr Thr Asn 
            260                 265                 270         


Arg Lys Thr His Ile Asp Gly Pro Thr Leu Leu Ile Glu Asn Ser Thr 
        275                 280                 285             


Ser Val Trp Gln Asp Ile Ile Leu Glu Ser Asp Thr Glu Phe Gln Glu 
    290                 295                 300                 


Val Thr Ser Leu Ile His Asp Glu Met Leu Met Asp Lys Asn Thr Thr 
305                 310                 315                 320 


Ala Leu Arg Leu Asn His Val Ser Asn Lys Thr Thr Ser Ser Lys Asn 
                325                 330                 335     


Met Glu Met Val His Gln Lys Lys Glu Gly Pro Val Pro Pro Asp Ala 
            340                 345                 350         


Glu Asn Pro Asp Met Ser Phe Phe Lys Met Leu Phe Leu Pro Glu Ser 
        355                 360                 365             


Ala Asn Trp Ile Lys Arg Thr His Gly Lys Asn Ser Leu Asn Ser Gly 
    370                 375                 380                 


Gln Gly Pro Ser Pro Lys Gln Leu Ile Ser Leu Gly Ser Glu Lys Ser 
385                 390                 395                 400 


Val Lys Asp Gln Asn Phe Leu Ser Glu Lys Asn Lys Val Val Val Gly 
                405                 410                 415     


Glu Asp Glu Phe Thr Lys Asp Thr Gly Leu Lys Glu Met Ile Phe Pro 
            420                 425                 430         


Asn Ser Arg Ser Ile Phe Leu Thr Asn Leu Ala Asn Val Gln Glu Asn 
        435                 440                 445             


Asp Thr His Asn Gln Glu Lys Lys Phe Gln Glu Glu Ile Glu Arg Lys 
    450                 455                 460                 


Glu Thr Leu Ile Gln Glu Asn Val Val Leu Pro Gln Val Tyr Thr Val 
465                 470                 475                 480 


Thr Gly Thr Lys Asn Phe Leu Lys Asn Leu Phe Leu Leu Ser Thr Arg 
                485                 490                 495     


Gln Asn Val Glu Gly Leu Asp Glu Gly Thr Tyr Ala Pro Val Leu Gln 
            500                 505                 510         


Asp Thr Arg Ser Leu Asn Asp Ser Thr Asn Arg Ala Glu Ile His Met 
        515                 520                 525             


Ala His Phe Ser Lys Arg Arg Glu Glu Glu Asn Leu Glu Gly Leu Gly 
    530                 535                 540                 


Asn Gln Thr Lys Gln Met Val Glu Lys Tyr Pro Ser Thr Thr Arg Met 
545                 550                 555                 560 


Ser Pro Asn Pro Ser Gln Gln Asn Val Ile Thr Gln Arg Gly Lys Arg 
                565                 570                 575     


Ala Leu Lys Gln Phe Arg Leu Pro Leu Glu Glu Thr Glu Leu Glu Lys 
            580                 585                 590         


Gly Leu Ile Val Asp Asp Thr Ser Thr Gln Trp Ser Lys Asn Met Lys 
        595                 600                 605             


Tyr Leu Thr Gln Ser Thr Leu Thr Gln Ile Asp Tyr Asn Glu Lys Glu 
    610                 615                 620                 


Lys Lys Ala Ile Thr Gln Ser Pro Leu Ser Asp Cys Ser Met Arg Asn 
625                 630                 635                 640 


His Ser Ile Thr Gln Thr Asn Ser Ser Ala Leu Pro Ile Ala Lys Val 
                645                 650                 655     


Ser Ala Phe Pro Ser Ile Arg Pro Thr Asp Leu Thr Lys Ile Pro Ser 
            660                 665                 670         


Gln Asp Asn Ser Ser His Leu Leu Ala Ser Ala Tyr Ser Tyr Thr Phe 
        675                 680                 685             


Arg Glu Lys Ser Ser Gly Val Gln Glu Ser Ser His Phe Leu Gln Gly 
    690                 695                 700                 


Ala Lys Arg Asn Asn Leu Ser Leu Ala Ile Leu Thr Leu Glu Met Ile 
705                 710                 715                 720 


Arg Asn Gln Glu Lys Val Gly Ser Leu Gly Thr Ser Ala Thr Asn Ser 
                725                 730                 735     


Val Met Tyr Lys Lys Leu Glu Asn Thr Val Leu Leu Lys Pro Gly Leu 
            740                 745                 750         


Pro Glu Ala Ser Gly Lys Val Glu Leu Leu Pro Lys Val His Ile His 
        755                 760                 765             


Gln Glu Asp Leu Phe Pro Thr Glu Thr Ser Asn Gly Ser Pro Gly His 
    770                 775                 780                 


Leu Asp Leu Met Glu Glu Ile Leu Leu Gln Lys Thr Gln Gly Ala Ile 
785                 790                 795                 800 


Lys Trp Asn Lys Thr Asn Arg Pro Gly Lys Val Pro Phe Leu Lys Gly 
                805                 810                 815     


Ala Thr Glu Ser Ser Glu Lys Thr Pro Ser Lys Leu Leu Gly Pro Leu 
            820                 825                 830         


Ala Trp Asp Asn Gln Tyr Ala Thr Gln Ile Pro Lys Glu Glu Trp Lys 
        835                 840                 845             


Ser Gln Glu Lys Ser Pro Lys Asn Thr Ala Phe Lys Thr Lys Asp Thr 
    850                 855                 860                 


Ile Leu Ser Leu Asn Pro Cys Glu Asn Asn His Ala Ile Ala Ala Ile 
865                 870                 875                 880 


Asn Glu Gly Gln Asp Arg Pro Gln Arg Glu Ala Thr Trp Ala Lys Gln 
                885                 890                 895     


Gly Gly Thr Gly Arg Leu Cys Ser Gln Asn Pro Pro Val Leu Lys Arg 
            900                 905                 910         


His Gln Arg 
        915 


<210>  25
<211>  41
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  25

Glu Ile Thr Leu Thr Thr Leu Gln Ser Glu Gln Glu Glu Ile Asp Tyr 
1               5                   10                  15      


Asp Asp Thr Ile Ser Ile Glu Thr Lys Arg Glu Asp Phe Asp Ile Tyr 
            20                  25                  30          


Gly Glu Asp Glu Asn Gln Gly Pro Arg 
        35                  40      


<210>  26
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  26

Ser Phe Gln Lys Arg Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg 
1               5                   10                  15      


Leu Trp Asp Tyr Gly Met Ser Arg Ser Pro His Val Leu Arg Asn Arg 
            20                  25                  30          


Ala Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu 
        35                  40                  45              


Phe Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn 
    50                  55                  60                  


Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp 
65                  70                  75                  80  


Asn Ile Met Val Thr Phe Lys Asn Gln Ala Ser Arg Pro Tyr Ser Phe 
                85                  90                  95      


Tyr Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu 
            100                 105                 110         


Pro Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp 
        115                 120                 125             


Lys Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys 
    130                 135                 140                 


Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Met His Ser 
145                 150                 155                 160 


Gly Leu Ile Gly Pro Leu Leu Ile Cys His Thr Asn Thr Leu Asn Pro 
                165                 170                 175     


Ala His Gly Arg Gln Val Thr Val Gln Glu Phe Ala Leu Phe Phe Thr 
            180                 185                 190         


Ile Phe Asp Glu Thr Lys Ser Trp Tyr Phe Thr Glu Asn Met Glu Arg 
        195                 200                 205             


Asn Cys Arg Ala Pro Cys Asn Ile Gln Met Glu Asp Pro Thr Phe Lys 
    210                 215                 220                 


Glu Asn Tyr Arg Phe His Ala Ile Asn Gly Tyr Val Met Asp Thr Leu 
225                 230                 235                 240 


Pro Gly Leu Val Met Ala Gln Asp Gln Arg Ile Arg Trp Tyr Leu Leu 
                245                 250                 255     


Ser Met Gly Ser Asn Glu Asn Ile His Ser Ile His Phe Ser Gly His 
            260                 265                 270         


Val Phe Thr Val Arg Lys Lys Glu Glu Tyr Lys Met Ala Val Tyr Asn 
        275                 280                 285             


Leu Tyr Pro Gly Val Phe Glu Thr Val Glu Met Leu Pro Ser Lys Ala 
    290                 295                 300                 


Gly Ile Trp Arg Val Glu Cys Leu Ile Gly Glu His Leu His Ala Gly 
305                 310                 315                 320 


Met Ser Thr Leu Phe Leu Val Tyr Ser Lys 
                325                 330 


<210>  27
<211>  153
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  27

Gln Cys Gln Thr Pro Leu Gly Met Ala Ser Gly His Ile Arg Asp Phe 
1               5                   10                  15      


Gln Ile Thr Ala Ser Gly Gln Tyr Gly Gln Trp Ala Pro Lys Leu Ala 
            20                  25                  30          


Arg Leu His Tyr Ser Gly Ser Ile Asn Ala Trp Ser Thr Lys Glu Pro 
        35                  40                  45              


Phe Ser Trp Ile Lys Val Asp Leu Leu Ala Pro Met Ile Ile His Gly 
    50                  55                  60                  


Ile Lys Thr Gln Gly Ala Arg Gln Lys Phe Ser Ser Leu Tyr Ile Ser 
65                  70                  75                  80  


Gln Phe Ile Ile Met Tyr Ser Leu Asp Gly Lys Lys Trp Gln Thr Tyr 
                85                  90                  95      


Arg Gly Asn Ser Thr Gly Thr Leu Met Val Phe Phe Gly Asn Val Asp 
            100                 105                 110         


Ser Ser Gly Ile Lys His Asn Ile Phe Asn Pro Pro Ile Ile Ala Arg 
        115                 120                 125             


Tyr Ile Arg Leu His Pro Thr His Tyr Ser Ile Arg Ser Thr Leu Arg 
    130                 135                 140                 


Met Glu Leu Met Gly Cys Asp Leu Asn 
145                 150             


<210>  28
<211>  160
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  28

Ser Cys Ser Met Pro Leu Gly Met Glu Ser Lys Ala Ile Ser Asp Ala 
1               5                   10                  15      


Gln Ile Thr Ala Ser Ser Tyr Phe Thr Asn Met Phe Ala Thr Trp Ser 
            20                  25                  30          


Pro Ser Gln Ala Arg Leu His Leu Gln Gly Arg Thr Asn Ala Trp Arg 
        35                  40                  45              


Pro Gln Val Asn Asn Pro Lys Glu Trp Leu Gln Val Asp Phe Gln Lys 
    50                  55                  60                  


Thr Met Lys Val Thr Gly Ile Thr Thr Gln Gly Val Lys Ser Leu Leu 
65                  70                  75                  80  


Thr Ser Met Tyr Val Lys Glu Phe Leu Ile Ser Ser Ser Gln Asp Gly 
                85                  90                  95      


His His Trp Thr Leu Phe Leu Gln Asn Gly Lys Val Lys Val Phe Gln 
            100                 105                 110         


Gly Asn Gln Asp Ser Phe Thr Pro Val Val Asn Ser Leu Asp Pro Pro 
        115                 120                 125             


Leu Leu Thr Arg Tyr Leu Arg Ile His Pro Gln Ser Trp Val His Gln 
    130                 135                 140                 


Ile Ala Leu Arg Leu Glu Val Leu Gly Cys Glu Ala Gln Gln Leu Tyr 
145                 150                 155                 160 


<210>  29
<211>  2360
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  29

Met Arg Ile Glu Leu Pro Cys Cys Phe Phe Leu Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Phe Gly Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Val His Ser Asp Leu Leu Ser Val Leu His Val Pro Thr 
        35                  40                  45              


Gly Phe Pro Gly Arg Val Gly Arg Lys Phe Pro Phe Ser Thr Ser Val 
    50                  55                  60                  


Arg Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Thr 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Arg Ala Glu Val Tyr Asp Thr Val Val Val Thr Leu Lys Asn Leu Ala 
            100                 105                 110         


Ser His Pro Phe Ser Leu His Ala Val Gly Val Thr Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Gly Tyr Asp Asp Glu Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Asp Pro Gly Lys Thr His Thr Tyr Val Trp Glu Val 
145                 150                 155                 160 


Leu Lys Asp Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser Tyr Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Pro Gly Ala Leu Ala Lys Asp Gly 
        195                 200                 205             


Thr Gln Thr Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp Tyr Pro Glu Pro Asn Glu Ser Leu Thr Gln Ala Leu 
225                 230                 235                 240 


Asp Thr Gly Thr Pro Arg Pro Trp Pro Lys Leu His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Gly Ser Leu Pro Gly Leu Ile Gly Cys His Lys Arg Pro 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Leu Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg His Ala 
    290                 295                 300                 


Thr Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Thr Asp Leu Gly Arg Phe Leu Leu Phe Cys His Ile Pro Ala His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Val Cys Pro Glu Glu 
            340                 345                 350         


Pro Lys Leu Arg Met Arg Ala Asp Ala Pro Glu Glu Asp Tyr Tyr Asp 
        355                 360                 365             


Asp Leu Tyr Asp Leu Asp Met Asp Val Ile Arg Phe Asp Asp Asp Asp 
    370                 375                 380                 


Ser Pro Pro Phe Ile Gly Val Arg Ala Phe Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Ile His Tyr Ile Ala Ala Glu Glu Val Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ile Val Pro Thr Tyr Leu Asp Arg Ser Tyr Lys Ser Gln Tyr Leu 
            420                 425                 430         


Glu Ala Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Val Ala Tyr Thr Asp Gly Thr Phe Lys Thr Arg Lys Val Ile Gln Tyr 
    450                 455                 460                 


Asp Thr Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Val Phe Lys Asn Leu Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Leu Thr Ser Val Ser Pro Leu His Pro Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Leu Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Gly Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Tyr Ser Phe Ile Asn Pro Val 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Arg 
            580                 585                 590         


Phe Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Ile Gln Arg Phe Cys Pro Asp Ala Ala Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Tyr Ala Ser Asn Val Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Asn Leu His Leu Lys Leu Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Val Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Phe Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Lys 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys Leu Asn Pro Asp Phe Arg Asp Arg 
705                 710                 715                 720 


Gly Met Trp Ala Leu Leu Lys Val Ser Ser Cys Asp Arg Asp Pro Gly 
                725                 730                 735     


Leu Tyr Tyr Gly Asp Asp Tyr Asp Leu Ile Pro Thr Tyr Leu Leu Asn 
            740                 745                 750         


Glu Asn Asn Val Leu Glu Pro Arg Gly Phe Pro Lys Asn Lys Arg Trp 
        755                 760                 765             


Pro Arg Leu Cys Leu Arg Lys Phe Lys Ala Val Thr Ser Pro Glu Lys 
    770                 775                 780                 


Asp Ile Glu Lys Leu Asp Pro Gln Phe Gly Glu Arg Thr Gln Cys Leu 
785                 790                 795                 800 


Arg Ala Gln Pro Leu Lys Phe Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Asn Pro Asp Pro His Gly Leu Ser Leu Ser Asp Leu Thr Glu Ala Thr 
            820                 825                 830         


Tyr Glu Pro Ile Pro Tyr Asp Ser Phe Pro Gly Pro Val Gly Asn Ser 
        835                 840                 845             


Thr Gly Pro Ser Glu Val Val His Leu Arg Pro Glu Leu His His Ala 
    850                 855                 860                 


Gly Asp Ala Gly Phe Tyr Pro Glu Gly Gly Leu Leu Leu Phe Gly Lys 
865                 870                 875                 880 


Glu Arg Leu Gly Pro Thr Val Ala Val Glu Leu Lys Lys Leu Asp Leu 
                885                 890                 895     


Lys Leu His Lys Ser Val Asp Asn Val Met Phe Ser Pro Thr Ala Pro 
            900                 905                 910         


Leu Asp Asn Leu Glu Lys Gly Leu Lys Gly Thr Gly Thr Leu Gly Pro 
        915                 920                 925             


Leu Lys Glu Pro Val Arg Phe Ser Gly His Leu Gly Pro Thr Val Phe 
    930                 935                 940                 


Gly Lys Lys Glu Thr Gly Leu Ile Gly Ser Gly Val Pro Leu Gln Leu 
945                 950                 955                 960 


Ser Asp Arg Asp His Asp Ser Arg Leu Leu Glu Arg Val Leu Leu Asn 
                965                 970                 975     


Asp Glu Glu Ser Pro Leu Gly Leu Asn Val Thr Ser Leu Lys Pro Asp 
            980                 985                 990         


Arg Pro Phe Lys Asp Lys Arg Val  His Gly Pro Ala Ser  Leu Thr Lys 
        995                 1000                 1005             


Asp Asn  Ala Leu Phe Lys Gly  Asn Ile Thr Leu Val  Lys Leu Asp 
    1010                 1015                 1020             


Lys Thr  Pro Asp Asn Thr Thr  Thr Asn Arg Lys Thr  Tyr Val Asp 
    1025                 1030                 1035             


Gly Pro  Ala Leu Leu Lys Glu  Asn Gly Thr Pro Val  Trp Leu Asp 
    1040                 1045                 1050             


Ile Leu  Glu Asn Asp Thr Arg  Phe Gln Glu Val Ala  Ser Leu Gly 
    1055                 1060                 1065             


Phe Tyr  Glu Thr Phe Gln Asp  Gly Lys Leu Thr Ala  Pro Gly Leu 
    1070                 1075                 1080             


Asp His  Val Leu Asn Lys Thr  Thr Ser Ser Lys Asn  Gly Glu Val 
    1085                 1090                 1095             


Phe Phe  Glu Lys Lys Val Glu  Pro Val Pro Leu Asp  Ala Glu Arg 
    1100                 1105                 1110             


Pro Pro  Ala Pro Phe Phe Lys  Asp Leu Phe Leu Pro  Arg Thr Ala 
    1115                 1120                 1125             


Asn Trp  Leu Leu Asp Thr His  Gly Lys Ala Asp Leu  Arg Ala Gly 
    1130                 1135                 1140             


Gln Gly  Pro Ser Pro Lys Gln  Leu Ile Ser Leu Gly  Ser Asp Lys 
    1145                 1150                 1155             


Ser Gly  Asp Gly Glu His Phe  Leu Ser Ala Lys Ser  Lys Val Arg 
    1160                 1165                 1170             


Leu Gly  Pro Asp Lys Phe Thr  Lys Gly Thr Gly Leu  Leu Glu Met 
    1175                 1180                 1185             


Ile Phe  Pro Gly Arg Lys Asp  Ile Phe Leu Thr Ser  Leu Val Thr 
    1190                 1195                 1200             


Val Gln  Glu Asn Asp Thr Leu  Ile Leu Gly Lys Lys  Phe Gln Glu 
    1205                 1210                 1215             


Ala Ile  Glu Arg Lys Glu Thr  Leu Ile Gln Glu Asn  Val Asp Leu 
    1220                 1225                 1230             


Pro Lys  Leu Tyr Val Val Ala  Gly Thr Arg Asn Phe  Leu Lys Asp 
    1235                 1240                 1245             


Leu Phe  Leu Leu His Thr Arg  Thr Asn Leu Thr Leu  Asp Gly Pro 
    1250                 1255                 1260             


Asp Glu  Gly Asp Tyr Ala Pro  Leu Leu Gln Asp Thr  Arg Tyr Leu 
    1265                 1270                 1275             


Asn Gly  Lys Val Pro Pro Ala  Gly Val His Leu Val  His Gly Ser 
    1280                 1285                 1290             


Lys Leu  Leu Glu Ala Ala Asp  Leu Glu Gly Leu Leu  His Lys Thr 
    1295                 1300                 1305             


Lys Arg  Met Val Leu Asp Tyr  Pro Ser Thr Thr Arg  Thr Ala Pro 
    1310                 1315                 1320             


Lys Pro  Cys Asp Gln Asn Cys  Ile Thr His Arg Gly  Lys Arg Ala 
    1325                 1330                 1335             


Leu Lys  Gln Phe Gly Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Arg 
    1340                 1345                 1350             


Gly Leu  Val Asp Lys Asp Arg  Ala Leu Lys Gly Arg  Lys Asn Met 
    1355                 1360                 1365             


Gly Tyr  Leu Thr Gly Gly Thr  Leu Thr Lys Ile Asp  Tyr Asn Asp 
    1370                 1375                 1380             


Arg Ala  Lys Arg Leu Val Ala  Arg Pro Pro Leu Val  Asp Cys Thr 
    1385                 1390                 1395             


Ala Arg  Asp His Gly Val Thr  Gly Thr Asp Gly Pro  Ala Gly Pro 
    1400                 1405                 1410             


Ile Arg  Gly Val Ser Ala Phe  Pro Pro Ile Arg Pro  Thr Asp Leu 
    1415                 1420                 1425             


Thr Lys  Leu Pro Ser His Asp  Asn Ser Ser His Leu  Pro Ala Ala 
    1430                 1435                 1440             


Ala Cys  Gly Tyr Thr Phe Arg  Glu Lys Ser Ser Gly  Val Arg Gly 
    1445                 1450                 1455             


Gly Ser  His Phe Leu Gln Gly  Ala Lys Arg Thr Ser  Leu Thr Ser 
    1460                 1465                 1470             


Ala Tyr  Leu Thr Leu Lys Thr  Ile Arg Gly Glu Glu  Lys Val Ser 
    1475                 1480                 1485             


Ser Leu  Gly Thr Ser Ala Asp  Thr Pro Pro Thr Tyr  Lys Lys Leu 
    1490                 1495                 1500             


Glu Asn  Thr Val Leu Leu Lys  Pro Gly Leu Pro Glu  Val Val Gly 
    1505                 1510                 1515             


Lys Val  Glu Gly Leu Pro Lys  Pro His Val Trp Glu  Ala Asp Leu 
    1520                 1525                 1530             


Phe Pro  Thr Pro Thr Gly Asn  Gly Thr Pro Gly His  Leu Asp Leu 
    1535                 1540                 1545             


Lys Glu  Glu Trp Leu Leu Gln  Lys Leu Gln Gly Ala  Ile Lys Leu 
    1550                 1555                 1560             


Ser Lys  Val Lys Arg Pro Gly  Asp Phe Pro Phe Leu  Lys Gly Ala 
    1565                 1570                 1575             


Thr Glu  Ile Leu Glu Lys Arg  Pro Ser Lys Leu Leu  Gly Pro Leu 
    1580                 1585                 1590             


Pro Trp  Asp Gly Gln Tyr Leu  Thr Gln Ile Leu Arg  Asp Glu Trp 
    1595                 1600                 1605             


Lys Leu  Lys His Lys Ser Pro  Lys Asn Thr Val Phe  Lys Thr Lys 
    1610                 1615                 1620             


Asp Ala  Ile Leu Pro Leu Ser  Gly Cys Glu Asn Val  His Gly Val 
    1625                 1630                 1635             


Asp Gly  Ile Asn Glu Gly Arg  Asp Arg Leu Gln Lys  Ala Ala Thr 
    1640                 1645                 1650             


Trp Ala  Lys Gln Gly Gly Thr  Glu Arg Leu Cys Ser  Arg Glu Pro 
    1655                 1660                 1665             


Pro Val  Leu Lys Asn His Lys  Arg Glu Ile Thr Leu  Thr Thr Leu 
    1670                 1675                 1680             


Gln Pro  Glu Lys Glu Lys Ile  Asp Tyr Asp Asp Tyr  Leu Lys Pro 
    1685                 1690                 1695             


Glu Thr  Asp Arg Asp Asp Phe  Asp Ile Tyr Gly Glu  Asp Glu Asn 
    1700                 1705                 1710             


Gln Gly  Pro Arg Thr Phe Thr  Gly Arg Thr Arg His  Tyr Phe Ile 
    1715                 1720                 1725             


Ala Ala  Val Glu Arg Leu Trp  Asp Tyr Gly Met Ser  Arg Pro Pro 
    1730                 1735                 1740             


His Phe  Leu Arg Asn Arg Ala  Arg Gly Gly Arg Val  Pro Phe Phe 
    1745                 1750                 1755             


Lys Lys  Val Val Phe Arg Gly  Phe Leu Asp Gly Ser  Phe Thr Gln 
    1760                 1765                 1770             


Pro Leu  Tyr Arg Gly Glu Leu  Asp Glu His Leu Gly  Leu Leu Gly 
    1775                 1780                 1785             


Pro Tyr  Ile Arg Ala Glu Val  Asp Asp Val Ile Met  Val Thr Phe 
    1790                 1795                 1800             


Lys Asn  Leu Ala Ser Arg Pro  Tyr Ser Phe Tyr Ser  Ser Leu Leu 
    1805                 1810                 1815             


Pro Tyr  Glu Gly Gly Leu Gly  Gln Gly Ser Glu Pro  Arg Lys Glu 
    1820                 1825                 1830             


Val Val  Lys Pro Gly Glu Leu  Arg Thr Tyr Phe Trp  Lys Val Leu 
    1835                 1840                 1845             


Pro His  Met Ala Pro Thr Val  Asp Glu Phe Asp Cys  Lys Ala Trp 
    1850                 1855                 1860             


Ala Tyr  Phe Ser Asp Val Asp  Leu Glu Lys Asp Leu  His Ser Gly 
    1865                 1870                 1875             


Leu Val  Gly Pro Leu Leu Ile  Cys Arg Pro Gly Thr  Leu Ser Pro 
    1880                 1885                 1890             


Ala Phe  Gly Arg Gln Leu Thr  Val Gln Glu Phe Ala  Leu Leu Phe 
    1895                 1900                 1905             


Thr Ile  Phe Asp Glu Thr Lys  Ser Trp Tyr Phe Thr  Glu Asn Met 
    1910                 1915                 1920             


Glu Arg  Asn Cys Pro Pro Pro  Cys Gln Ile Gln Pro  Asp Asp Pro 
    1925                 1930                 1935             


Asp Phe  Arg Arg Ser Tyr Arg  Phe His Ala Ile Asn  Gly Tyr Val 
    1940                 1945                 1950             


Met Asp  Thr Leu Pro Gly Leu  Val Met Ala Gln Asp  Gln Arg Val 
    1955                 1960                 1965             


Arg Trp  Tyr Leu Leu Ser Val  Gly Gly Thr Glu Asp  Ile His Ser 
    1970                 1975                 1980             


Val Tyr  Phe His Gly His Val  Phe Thr Val Arg Lys  Lys His Glu 
    1985                 1990                 1995             


Tyr Arg  Met Gly Val Tyr Asn  Leu Tyr Pro Gly Val  Phe Gly Thr 
    2000                 2005                 2010             


Val Glu  Met Leu Pro Ser Lys  Pro Gly Ile Trp Arg  Val Glu Cys 
    2015                 2020                 2025             


Leu Val  Gly Glu His Leu Gln  Ala Gly Met Ser Thr  Leu Phe Leu 
    2030                 2035                 2040             


Val Tyr  Asp Pro Lys Cys Gln  Thr Pro Leu Gly Leu  Ala Ser Gly 
    2045                 2050                 2055             


His Ile  Arg Asp Ala Gln Ile  Thr Ala Ser Gly Gln  Tyr Gly Gln 
    2060                 2065                 2070             


Trp Ala  Pro Arg Leu Ala Arg  Leu His Tyr Ser Gly  Ser Val Asn 
    2075                 2080                 2085             


Ala Trp  Ser Thr Lys Asp Pro  Phe Ser Trp Ile Lys  Val Asp Leu 
    2090                 2095                 2100             


Leu Arg  Pro Met Ile Leu His  Gly Ile Lys Thr Gln  Gly Ala Arg 
    2105                 2110                 2115             


Gln Lys  Phe Ser Ser Leu Tyr  Ile Ser Gln Phe Ile  Ile Phe Tyr 
    2120                 2125                 2130             


Gly Leu  Asp Gly Lys Arg Trp  Lys Arg Tyr Arg Gly  Asn Ala Thr 
    2135                 2140                 2145             


Gly Thr  Leu Met Val Phe Phe  Gly Asn Val Asp Ala  Thr Gly Val 
    2150                 2155                 2160             


Lys His  Asn Arg Phe Asn Pro  Pro Ile Ile Ala Arg  Tyr Ile Arg 
    2165                 2170                 2175             


Leu His  Pro Thr His Tyr Ser  Ile Arg Thr Thr Leu  Arg Met Glu 
    2180                 2185                 2190             


Leu Ile  Gly Cys Asp Leu Asn  Ser Cys Ser Met Pro  Leu Gly Met 
    2195                 2200                 2205             


Glu Asn  Lys Ala Ile Ser Asp  Ala Gln Ile Thr Ala  Ser Ser Tyr 
    2210                 2215                 2220             


Phe Thr  Asn Met Phe Ala Thr  Trp Ala Pro Ser Gln  Ala Arg Leu 
    2225                 2230                 2235             


His Leu  Gln Gly Arg Thr Asn  Ala Trp Arg Pro Lys  Val Asn Ser 
    2240                 2245                 2250             


Pro Lys  Glu Trp Leu Gln Val  Asp Phe Glu Lys Thr  Met Arg Val 
    2255                 2260                 2265             


Thr Gly  Ile Val Thr Gln Gly  Ala Lys Ser Leu Leu  Thr Ser Met 
    2270                 2275                 2280             


Tyr Val  Lys Glu Phe Leu Val  Ser Ser Ser Gln Asp  Gly His Arg 
    2285                 2290                 2295             


Trp Thr  Pro Phe Leu Gln Asp  Gly Lys Val Lys Val  Phe Lys Gly 
    2300                 2305                 2310             


Asn Gln  Asp His Phe Thr Pro  Val Val Asn Ser Leu  Asp Pro Pro 
    2315                 2320                 2325             


Leu Leu  Thr Arg Tyr Leu Arg  Ile His Pro Arg Arg  Trp Val His 
    2330                 2335                 2340             


His Ile  Ala Leu Arg Leu Glu  Phe Leu Gly Cys Asp  Ala Gln Gln 
    2345                 2350                 2355             


Leu Tyr  
    2360 


<210>  30
<211>  2362
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  30

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Arg Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Ile Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Asn Glu Ser Leu Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Tyr Asp Ser Asp Met Asp Val Val Arg Phe Asp Asp Asp Asn 
    370                 375                 380                 


Ser Pro Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Pro Asn Asp Arg Ser Tyr Lys Ser Gln Tyr Leu 
            420                 425                 430         


Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Ser Pro Leu His Ser Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Leu Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Arg Asn Thr Gly 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Pro Thr Tyr Leu Leu Asn 
            740                 745                 750         


Glu Asn Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
        755                 760                 765             


Pro Ser Thr Arg Gln Lys Gln Phe Lys Ala Thr Thr Thr Pro Glu Asn 
    770                 775                 780                 


Asp Ile Glu Lys Ile Asp Pro Gln Phe Gly Glu Arg Thr Gln Leu Leu 
785                 790                 795                 800 


Lys Val Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Thr 
            820                 825                 830         


Tyr Glu Ala Ile Pro Asp Asp His Ser Pro Gly Ala Ile Glu Ser Asn 
        835                 840                 845             


Glu Gly Pro Ser Glu Val Ala His Leu Arg Pro Glu Leu His His Ser 
    850                 855                 860                 


Gly Asp Met Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Leu Asn 
865                 870                 875                 880 


Glu Asn Leu Gly Thr Thr Ile Thr Val Glu Leu Lys Lys Leu Asp Leu 
                885                 890                 895     


Lys Val Ser Ser Ser Ser Asn Asn Leu Met Thr Ser Pro Thr Ile Pro 
            900                 905                 910         


Ser Asp Asn Leu Ala Ala Gly Thr Glu Lys Thr Gly Ser Leu Gly Pro 
        915                 920                 925             


Pro Asn Met Pro Val His Phe Ser Ser Gln Leu Gly Thr Ile Val Phe 
    930                 935                 940                 


Gly Lys Lys Ser Ser Pro Leu Ile Gly Ser Gly Val Pro Leu Asn Leu 
945                 950                 955                 960 


Ser Glu Arg Asp Asn Asp Ser Lys Leu Leu Glu Ala Ala Leu Met Asn 
                965                 970                 975     


Ser Gln Glu Ser Ser Leu Gly Lys Asn Val Ser Ser Met Glu Ser Asp 
            980                 985                 990         


Arg Leu Phe Lys Glu Lys Arg Val  His Gly Pro Ala Ser  Leu Thr Lys 
        995                 1000                 1005             


Asp Asn  Ala Leu Phe Lys Val  Asn Ile Ser Leu Val  Lys Thr Asn 
    1010                 1015                 1020             


Lys Thr  Pro Asn Asn Ser Thr  Thr Asn Arg Lys Thr  His Ile Asp 
    1025                 1030                 1035             


Gly Pro  Thr Leu Leu Ile Glu  Asn Ser Thr Ser Val  Trp Gln Asp 
    1040                 1045                 1050             


Ile Leu  Glu Asn Asp Thr Glu  Phe Gln Glu Val Thr  Ser Leu Ile 
    1055                 1060                 1065             


His Asp  Glu Met Phe Met Asp  Lys Asn Thr Thr Ala  Leu Gly Leu 
    1070                 1075                 1080             


Asn His  Val Ser Asn Lys Thr  Thr Ser Ser Lys Asn  Met Glu Met 
    1085                 1090                 1095             


Val His  Gln Lys Lys Glu Gly  Pro Val Pro Leu Asp  Ala Glu Asn 
    1100                 1105                 1110             


Pro Asp  Met Ser Phe Phe Lys  Met Leu Phe Leu Pro  Asp Ser Ala 
    1115                 1120                 1125             


Asn Trp  Ile Lys Arg Thr His  Gly Lys Asn Ser Leu  Ser Ser Gly 
    1130                 1135                 1140             


Gln Gly  Pro Ser Pro Lys Gln  Leu Ile Ser Leu Gly  Ser Glu Lys 
    1145                 1150                 1155             


Ser Val  Lys Asp Gln Asn Phe  Leu Ser Glu Lys Asn  Lys Val Val 
    1160                 1165                 1170             


Val Gly  Glu Asp Glu Phe Thr  Lys Asp Thr Gly Leu  Lys Glu Met 
    1175                 1180                 1185             


Ile Phe  Pro Asn Ser Lys Ser  Ile Phe Leu Thr Asn  Leu Ala Asn 
    1190                 1195                 1200             


Val Gln  Glu Asn Asp Thr His  Asn Gln Glu Lys Lys  Phe Gln Glu 
    1205                 1210                 1215             


Glu Ile  Glu Arg Lys Glu Thr  Leu Ile Gln Glu Asn  Val Val Leu 
    1220                 1225                 1230             


Pro Gln  Val Tyr Thr Val Thr  Gly Thr Lys Asn Phe  Leu Lys Asn 
    1235                 1240                 1245             


Leu Phe  Leu Leu Ser Thr Arg  Gln Asn Val Thr Val  Glu Gly Leu 
    1250                 1255                 1260             


Asp Glu  Gly Thr Tyr Ala Pro  Val Leu Gln Asp Thr  Arg Ser Leu 
    1265                 1270                 1275             


Asn Asp  Ser Ala Asn Arg Ala  Gly Ile His Met Ala  His Phe Ser 
    1280                 1285                 1290             


Lys Arg  Arg Glu Glu Ala Glu  Thr Asn Leu Glu Gly  Leu Gly Asn 
    1295                 1300                 1305             


Gln Thr  Lys Gln Met Val Glu  Lys Tyr Pro Ser Thr  Thr Arg Met 
    1310                 1315                 1320             


Ser Pro  Asn Pro Ser Gln Gln  Asn Val Ile Thr Gln  Arg Gly Lys 
    1325                 1330                 1335             


Arg Ala  Leu Lys Gln Phe Arg  Leu Pro Leu Glu Glu  Ile Glu Leu 
    1340                 1345                 1350             


Glu Arg  Gly Leu Ile Val Asn  Asp Thr Ser Thr Gln  Trp Ser Lys 
    1355                 1360                 1365             


Asn Met  Lys Tyr Leu Thr Gln  Gly Thr Leu Thr Gln  Ile Asp Tyr 
    1370                 1375                 1380             


Asn Glu  Lys Glu Lys Arg Ala  Ile Thr Gln Ser Pro  Leu Ser Asp 
    1385                 1390                 1395             


Cys Ser  Met Arg Asn His Ser  Ile Thr Gln Thr Asn  Gly Ser Ala 
    1400                 1405                 1410             


Leu Pro  Ile Ala Lys Val Ser  Ala Phe Pro Ser Ile  Arg Pro Thr 
    1415                 1420                 1425             


Asp Leu  Thr Lys Ile Pro Ser  Gln Asp Asn Ser Ser  His Leu Leu 
    1430                 1435                 1440             


Ala Ser  Ala Cys Ser Tyr Thr  Phe Arg Glu Lys Ser  Ser Gly Val 
    1445                 1450                 1455             


Gln Glu  Ser Ser His Phe Leu  Gln Gly Ala Lys Arg  Asn Asn Leu 
    1460                 1465                 1470             


Ser Leu  Ala Ile Leu Thr Leu  Glu Met Ile Arg Gly  Gln Glu Lys 
    1475                 1480                 1485             


Val Ser  Ser Leu Gly Thr Ser  Ala Thr Asn Pro Leu  Met Tyr Lys 
    1490                 1495                 1500             


Lys Leu  Glu Asn Thr Val Leu  Leu Lys Pro Gly Leu  Pro Glu Ala 
    1505                 1510                 1515             


Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val His Val  His Gln Glu 
    1520                 1525                 1530             


Asp Leu  Phe Pro Thr Glu Thr  Ser Asn Gly Ser Pro  Gly His Leu 
    1535                 1540                 1545             


Asp Leu  Met Glu Glu Ile Leu  Leu Gln Lys Thr Gln  Gly Ala Ile 
    1550                 1555                 1560             


Lys Leu  Asn Lys Val Asn Arg  Pro Gly Lys Val Pro  Phe Leu Lys 
    1565                 1570                 1575             


Gly Ala  Thr Glu Ser Ser Glu  Lys Thr Pro Ser Lys  Leu Leu Gly 
    1580                 1585                 1590             


Pro Leu  Ala Trp Asp Asn Gln  Tyr Ala Thr Gln Ile  Pro Arg Glu 
    1595                 1600                 1605             


Glu Trp  Lys Ser Gln Glu Lys  Ser Pro Lys Asn Thr  Ala Phe Lys 
    1610                 1615                 1620             


Thr Lys  Asp Thr Ile Leu Pro  Leu Asn Pro Cys Glu  Asn Asn His 
    1625                 1630                 1635             


Ala Ile  Ala Ala Ile Asn Glu  Gly Gln Asp Arg Pro  Gln Arg Glu 
    1640                 1645                 1650             


Ala Thr  Trp Ala Lys Gln Gly  Gly Thr Gly Arg Leu  Cys Ser Gln 
    1655                 1660                 1665             


Asn Pro  Pro Val Leu Lys Arg  His Gln Arg Glu Ile  Thr Leu Thr 
    1670                 1675                 1680             


Thr Leu  Gln Pro Glu Gln Glu  Lys Ile Asp Tyr Asp  Asp Thr Ile 
    1685                 1690                 1695             


Ser Ile  Glu Thr Lys Arg Glu  Asp Phe Asp Ile Tyr  Gly Glu Asp 
    1700                 1705                 1710             


Glu Asn  Gln Gly Pro Arg Ser  Phe Gln Lys Arg Thr  Arg His Tyr 
    1715                 1720                 1725             


Phe Ile  Ala Ala Val Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Arg 
    1730                 1735                 1740             


Ser Pro  His Ala Leu Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro 
    1745                 1750                 1755             


Gln Phe  Lys Lys Val Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe 
    1760                 1765                 1770             


Thr Gln  Pro Leu Tyr Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu 
    1775                 1780                 1785             


Leu Gly  Pro Tyr Ile Arg Ala  Glu Val Glu Asp Asn  Ile Met Val 
    1790                 1795                 1800             


Thr Phe  Lys Asn Gln Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser 
    1805                 1810                 1815             


Leu Ile  Ser Tyr Glu Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg 
    1820                 1825                 1830             


Lys Asn  Phe Val Lys Pro Asn  Glu Thr Lys Thr Tyr  Phe Trp Lys 
    1835                 1840                 1845             


Val Gln  His His Met Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys 
    1850                 1855                 1860             


Ala Trp  Ala Tyr Phe Ser Asp  Val Asp Leu Glu Lys  Asp Met His 
    1865                 1870                 1875             


Ser Gly  Leu Ile Gly Pro Leu  Leu Ile Cys Arg Thr  Asn Thr Leu 
    1880                 1885                 1890             


Asn Pro  Ala His Gly Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu 
    1895                 1900                 1905             


Phe Phe  Thr Ile Phe Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu 
    1910                 1915                 1920             


Asn Met  Glu Arg Asn Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu 
    1925                 1930                 1935             


Asp Pro  Thr Phe Lys Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly 
    1940                 1945                 1950             


Tyr Val  Met Asp Thr Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln 
    1955                 1960                 1965             


Arg Ile  Arg Trp Tyr Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile 
    1970                 1975                 1980             


His Ser  Ile His Phe Ser Gly  His Val Phe Thr Val  Arg Lys Lys 
    1985                 1990                 1995             


Glu Glu  Tyr Lys Met Ala Val  Tyr Asn Leu Tyr Pro  Gly Val Phe 
    2000                 2005                 2010             


Glu Thr  Val Glu Met Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Val 
    2015                 2020                 2025             


Glu Cys  Leu Ile Gly Glu His  Leu Gln Ala Gly Met  Ser Thr Leu 
    2030                 2035                 2040             


Phe Leu  Val Tyr Ser Lys Gln  Cys Gln Thr Pro Leu  Gly Met Ala 
    2045                 2050                 2055             


Ser Gly  Arg Ile Arg Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr 
    2060                 2065                 2070             


Gly Gln  Trp Ala Pro Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser 
    2075                 2080                 2085             


Ile Asn  Ala Trp Ser Thr Lys  Asp Pro Phe Ser Trp  Ile Lys Val 
    2090                 2095                 2100             


Asp Leu  Leu Ala Pro Met Ile  Ile His Gly Ile Lys  Thr Gln Gly 
    2105                 2110                 2115             


Ala Arg  Gln Lys Phe Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile 
    2120                 2125                 2130             


Met Tyr  Ser Leu Asp Gly Lys  Lys Trp Gln Ser Tyr  Arg Gly Asn 
    2135                 2140                 2145             


Ser Thr  Gly Thr Leu Met Val  Phe Phe Gly Asn Val  Asp Ser Ser 
    2150                 2155                 2160             


Gly Ile  Lys His Asn Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr 
    2165                 2170                 2175             


Ile Arg  Leu His Pro Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg 
    2180                 2185                 2190             


Met Glu  Leu Met Gly Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu 
    2195                 2200                 2205             


Gly Met  Glu Ser Lys Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser 
    2210                 2215                 2220             


Ser Tyr  Phe Thr Asn Met Phe  Ala Thr Trp Ser Pro  Ser Gln Ala 
    2225                 2230                 2235             


Arg Leu  His Leu Gln Gly Arg  Thr Asn Ala Trp Arg  Pro Gln Val 
    2240                 2245                 2250             


Asn Asn  Pro Lys Glu Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met 
    2255                 2260                 2265             


Lys Val  Thr Gly Ile Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr 
    2270                 2275                 2280             


Ser Met  Tyr Val Lys Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly 
    2285                 2290                 2295             


His His  Trp Thr Leu Phe Leu  Gln Asn Gly Lys Val  Lys Val Phe 
    2300                 2305                 2310             


Gln Gly  Asn Gln Asp Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp 
    2315                 2320                 2325             


Pro Pro  Leu Leu Thr Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp 
    2330                 2335                 2340             


Val His  Gln Ile Ala Leu Arg  Leu Glu Val Leu Gly  Cys Glu Ala 
    2345                 2350                 2355             


Gln Gln  Leu Tyr 
    2360         


<210>  31
<211>  2351
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  31

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Thr Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Val Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Ser Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Thr Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Val Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Asn Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Ile Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Glu Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Gln Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Glu Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Asn Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Arg Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Glu  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Pro Arg Thr Thr Arg  Ile Ser Pro Asn Pro  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Gly  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Thr  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Asp Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Pro Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Leu  Lys Pro Gly 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Glu Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Ile 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Gly Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Gly  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Leu Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Lys  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Val Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Ile Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His His Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Glu Leu  Tyr 
    2345                 2350     


<210>  32
<211>  2351
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  32

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Arg Phe 
1               5                   10                  15      


Cys Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Gly Glu Leu Pro Val Asp Ala Arg 
        35                  40                  45              


Phe Pro Pro Arg Val Pro Lys Ser Phe Pro Phe Asn Thr Ser Val Val 
    50                  55                  60                  


Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn Ile 
65                  70                  75                  80  


Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile Gln 
                85                  90                  95      


Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala Ser 
            100                 105                 110         


His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala Ser 
        115                 120                 125             


Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu Asp 
    130                 135                 140                 


Asp Lys Val Phe Pro Gly Gly Ser His Thr Tyr Val Trp Gln Val Leu 
145                 150                 155                 160 


Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Leu Cys Leu Thr Tyr Ser 
                165                 170                 175     


Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu Ile 
            180                 185                 190         


Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Lys Thr 
        195                 200                 205             


Gln Thr Leu His Lys Phe Ile Leu Leu Phe Ala Val Phe Asp Glu Gly 
    210                 215                 220                 


Lys Ser Trp His Ser Glu Thr Lys Asn Ser Leu Met Gln Asp Arg Asp 
225                 230                 235                 240 


Ala Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly Tyr 
                245                 250                 255     


Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser Val 
            260                 265                 270         


Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile 
        275                 280                 285             


Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser 
    290                 295                 300                 


Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu Met 
305                 310                 315                 320 


Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His 
                325                 330                 335     


Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro 
            340                 345                 350         


Gln Leu Arg Met Lys Asn Asn Glu Glu Ala Glu Asp Tyr Asp Asp Asp 
        355                 360                 365             


Leu Thr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Ser Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr 
385                 390                 395                 400 


Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro 
                405                 410                 415     


Leu Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn 
            420                 425                 430         


Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met 
        435                 440                 445             


Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu 
    450                 455                 460                 


Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu 
465                 470                 475                 480 


Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro 
                485                 490                 495     


His Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys 
            500                 505                 510         


Gly Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe 
        515                 520                 525             


Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp 
    530                 535                 540                 


Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Met Glu Arg 
545                 550                 555                 560 


Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu 
                565                 570                 575     


Ser Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val 
            580                 585                 590         


Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu 
        595                 600                 605             


Asn Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp 
    610                 615                 620                 


Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val 
625                 630                 635                 640 


Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp 
                645                 650                 655     


Tyr Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe 
            660                 665                 670         


Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr 
        675                 680                 685             


Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro 
    690                 695                 700                 


Gly Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly 
705                 710                 715                 720 


Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp 
                725                 730                 735     


Tyr Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys 
            740                 745                 750         


Asn Asn Ala Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro 
        755                 760                 765             


Ser Thr Arg Gln Lys Gln Phe Asn Ala Thr Thr Ile Pro Glu Asn Asp 
    770                 775                 780                 


Ile Glu Lys Thr Asp Pro Trp Phe Ala His Arg Thr Pro Met Pro Lys 
785                 790                 795                 800 


Val Gln Asn Val Ser Ser Ser Asp Leu Leu Met Leu Leu Arg Gln Ser 
                805                 810                 815     


Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys Tyr 
            820                 825                 830         


Glu Thr Phe Ser Asp Asp Pro Ser Pro Gly Ala Ile Asp Ser Asn Asn 
        835                 840                 845             


Ser Leu Ser Glu Met Thr His Phe Arg Pro Gln Leu His His Ser Gly 
    850                 855                 860                 


Asp Met Val Phe Thr Pro Glu Ser Gly Leu Gln Leu Arg Leu Asn Glu 
865                 870                 875                 880 


Lys Leu Gly Thr Thr Ala Ala Thr Glu Leu Lys Lys Leu Asp Phe Lys 
                885                 890                 895     


Val Ser Ser Thr Ser Asn Asn Leu Ile Ser Thr Ile Pro Ser Asp Asn 
            900                 905                 910         


Leu Ala Ala Gly Thr Asp Asn Thr Ser Ser Leu Gly Pro Pro Ser Met 
        915                 920                 925             


Pro Val His Tyr Asp Ser Gln Leu Asp Thr Thr Leu Phe Gly Lys Lys 
    930                 935                 940                 


Ser Ser Pro Leu Thr Glu Ser Gly Gly Pro Leu Ser Leu Ser Glu Glu 
945                 950                 955                 960 


Asn Asn Asp Ser Lys Leu Leu Glu Ser Gly Leu Met Asn Ser Gln Glu 
                965                 970                 975     


Ser Ser Trp Gly Lys Asn Val Ser Ser Thr Glu Ser Gly Arg Leu Phe 
            980                 985                 990         


Lys Gly Lys Arg Ala His Gly Pro  Ala Leu Leu Thr Lys  Asp Asn Ala 
        995                 1000                 1005             


Leu Phe  Lys Val Ser Ile Ser  Leu Leu Lys Thr Asn  Lys Thr Ser 
    1010                 1015                 1020             


Asn Asn  Ser Ala Thr Asn Arg  Lys Thr His Ile Asp  Gly Pro Ser 
    1025                 1030                 1035             


Leu Leu  Ile Glu Asn Ser Pro  Ser Val Trp Gln Asn  Ile Leu Glu 
    1040                 1045                 1050             


Ser Asp  Thr Glu Phe Gln Lys  Val Thr Pro Leu Ile  His Asp Arg 
    1055                 1060                 1065             


Met Leu  Met Asp Lys Asn Ala  Thr Ala Leu Arg Leu  Asn His Met 
    1070                 1075                 1080             


Ser Asn  Lys Thr Thr Ser Ser  Lys Asn Met Glu Met  Val Gln Gln 
    1085                 1090                 1095             


Lys Lys  Glu Gly Pro Ile Pro  Pro Asp Ala Glu Asn  Pro Asp Met 
    1100                 1105                 1110             


Ser Phe  Phe Lys Met Leu Phe  Leu Pro Glu Ser Ala  Ser Trp Ile 
    1115                 1120                 1125             


Gln Arg  Thr His Gly Lys Asn  Ser Leu Asn Ser Gly  Gln Gly Pro 
    1130                 1135                 1140             


Ser Pro  Lys Gln Leu Val Ser  Leu Gly Pro Glu Lys  Ser Val Glu 
    1145                 1150                 1155             


Gly Gln  Asn Phe Leu Ser Glu  Lys Asn Lys Val Val  Val Gly Lys 
    1160                 1165                 1170             


Gly Glu  Phe Thr Lys Asp Val  Gly Leu Lys Glu Met  Val Phe Pro 
    1175                 1180                 1185             


Ser Ser  Arg Asn Leu Phe Leu  Thr Asn Leu Asp Asn  Leu His Glu 
    1190                 1195                 1200             


Asn Asn  Thr His Asn Gln Glu  Lys Lys Ile Gln Glu  Glu Ile Glu 
    1205                 1210                 1215             


Arg Lys  Glu Thr Leu Ile Gln  Glu Asn Val Val Leu  Pro Gln Ile 
    1220                 1225                 1230             


His Thr  Val Thr Gly Thr Lys  Asn Phe Met Lys Asn  Leu Phe Leu 
    1235                 1240                 1245             


Leu Ser  Thr Arg Gln Asn Val  Glu Gly Ser Tyr Glu  Gly Ala Tyr 
    1250                 1255                 1260             


Ala Pro  Val Leu Gln Asp Phe  Arg Ser Leu Asn Asp  Ser Thr Asn 
    1265                 1270                 1275             


Arg Thr  Lys Lys His Thr Ala  His Phe Ser Lys Lys  Gly Glu Glu 
    1280                 1285                 1290             


Glu Asn  Leu Glu Gly Leu Gly  Asn Gln Thr Lys Gln  Ile Val Glu 
    1295                 1300                 1305             


Lys Tyr  Ala Cys Thr Thr Arg  Ile Ser Pro Asn Thr  Ser Gln Gln 
    1310                 1315                 1320             


Asn Phe  Val Thr Gln Arg Ser  Lys Arg Ala Leu Lys  Gln Phe Arg 
    1325                 1330                 1335             


Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys Arg Ile  Ile Val Asp 
    1340                 1345                 1350             


Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met Lys His  Leu Thr Pro 
    1355                 1360                 1365             


Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu Lys Glu  Lys Gly Ala 
    1370                 1375                 1380             


Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Leu Thr Arg  Ser His Ser 
    1385                 1390                 1395             


Ile Pro  Gln Ala Asn Arg Ser  Pro Leu Pro Ile Ala  Lys Val Ser 
    1400                 1405                 1410             


Ser Phe  Pro Ser Ile Arg Pro  Ile Tyr Leu Thr Arg  Val Leu Phe 
    1415                 1420                 1425             


Gln Asp  Asn Ser Ser His Leu  Pro Ala Ala Ser Tyr  Arg Lys Lys 
    1430                 1435                 1440             


Asp Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Lys Asn  Asn Leu Ser Leu Ala  Ile Leu Thr Leu Glu  Met Thr Gly 
    1460                 1465                 1470             


Asp Gln  Arg Glu Val Gly Ser  Leu Gly Thr Ser Ala  Thr Asn Ser 
    1475                 1480                 1485             


Val Thr  Tyr Lys Lys Val Glu  Asn Thr Val Leu Pro  Lys Pro Gly 
    1490                 1495                 1500             


Leu Pro  Lys Thr Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Ile Tyr  Gln Lys Asp Leu Phe  Pro Thr Glu Thr Ser  Asn Gly Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Val  Glu Gly Ser Leu Leu  Gln Glu Thr 
    1535                 1540                 1545             


Glu Gly  Ala Ile Lys Trp Asn  Glu Ala Asn Arg Pro  Gly Lys Ile 
    1550                 1555                 1560             


Pro Phe  Leu Arg Val Ala Thr  Glu Ser Ser Ala Lys  Thr Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Gly Pro Leu Ala  Trp Asp Asn His Tyr  Gly Thr Gln 
    1580                 1585                 1590             


Ile Pro  Lys Glu Glu Trp Lys  Ser Gln Glu Lys Ser  Pro Glu Lys 
    1595                 1600                 1605             


Thr Ala  Phe Lys Lys Lys Asp  Thr Ile Leu Ser Leu  Asn Ala Cys 
    1610                 1615                 1620             


Glu Ser  Asn His Ala Ile Ala  Ala Ile Asn Glu Gly  Gln Asn Lys 
    1625                 1630                 1635             


Pro Glu  Ile Glu Val Thr Trp  Ala Lys Gln Gly Arg  Thr Glu Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Leu Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Arg Thr Thr Leu Gln  Ser Asp Gln Glu Glu  Ile Asp Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Ile Ser Val Glu  Met Lys Lys Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Asp  Glu Asp Glu Asn Gln  Ser Pro Arg Ser Phe  Gln Lys Lys 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Ser Ser Pro His  Val Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Ser  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Lys  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Asn Phe  Val Lys Pro Asn Glu  Thr Lys Thr 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Val Cys His 
    1865                 1870                 1875             


Thr Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Met Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Ile Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Arg Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Leu Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Ala Gly 
    2000                 2005                 2010             


Ile Trp  Arg Val Glu Cys Leu  Ile Gly Glu His Leu  His Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Asn Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Glu  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Gly Ile 
    2090                 2095                 2100             


Lys Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Thr 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Ser Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Phe  Thr Asn Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Lys Ala Arg Leu His  Leu Gln Gly Arg Ser  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Val Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Ile Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His His Trp  Thr Leu Phe Phe Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Val His Gln  Ile Ala Leu Arg Met  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Asp Leu  Tyr 
    2345                 2350     


<210>  33
<211>  2360
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  33

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Gln Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Met Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Met Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Gly Ser Leu Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Leu Asp Ser Glu Met Asp Val Phe Arg Phe Asp Asp Asp Asn 
    370                 375                 380                 


Ser Pro Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Ile His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Ser Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu 
            420                 425                 430         


Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Thr Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Ser Pro Leu His Ser Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Leu Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Arg Asn Thr Gly 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Pro Thr Tyr Leu Leu Ser 
            740                 745                 750         


Glu Asn Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
        755                 760                 765             


Pro Ser Thr Arg Gln Lys Gln Phe Lys Ala Thr Thr Ile Pro Glu Asn 
    770                 775                 780                 


Asp Ile Glu Lys Ile Asp Pro Gln Phe Gly Glu Arg Thr Gln Met Leu 
785                 790                 795                 800 


Lys Val Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Thr 
            820                 825                 830         


Tyr Glu Ala Ile Pro Asp Asp His Ser Pro Gly Ala Ile Asp Ser Asn 
        835                 840                 845             


Glu Gly Pro Ser Glu Val Ala His Leu Arg Pro Glu Leu His His Ser 
    850                 855                 860                 


Gly Asp Ile Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Leu Asn 
865                 870                 875                 880 


Glu Asn Leu Gly Thr Thr Ile Ala Val Glu Leu Lys Lys Leu Asp Leu 
                885                 890                 895     


Lys Val Ser Ser Ser Pro Asn Asn Leu Met Thr Ser Pro Thr Ile Pro 
            900                 905                 910         


Ser Asp Asn Leu Ala Ala Gly Thr Glu Lys Thr Gly Ser Leu Gly Pro 
        915                 920                 925             


Pro Asn Met Pro Val His Phe Ser Ser Gln Leu Ser Thr Thr Val Phe 
    930                 935                 940                 


Gly Lys Lys Ser Ser Pro Leu Ile Gly Ser Gly Val Pro Leu Asn Leu 
945                 950                 955                 960 


Ser Glu Arg Asn Asn Asp Ser Lys Leu Leu Glu Ala Ala Leu Met Asn 
                965                 970                 975     


Ser Gln Glu Ser Ser Leu Gly Lys Asn Val Ser Ser Met Glu Ser Asp 
            980                 985                 990         


Arg Leu Phe Lys Glu Lys Arg Val  His Gly Pro Ala Leu  Leu Thr Lys 
        995                 1000                 1005             


Asp Asn  Ala Leu Phe Lys Val  Asn Ile Ser Leu Ile  Lys Thr Asn 
    1010                 1015                 1020             


Lys Thr  Ser Asn Asn Ser Thr  Thr Asn Arg Lys Thr  His Ile Asp 
    1025                 1030                 1035             


Gly Pro  Thr Leu Leu Ile Glu  Asn Ser Thr Ser Val  Trp Gln Asp 
    1040                 1045                 1050             


Thr Ile  Leu Glu Ser Asp Thr  Glu Phe Gln Glu Val  Thr Ser Leu 
    1055                 1060                 1065             


Ile His  Asp Glu Met Leu Met  Asp Lys Asn Thr Thr  Ala Leu Arg 
    1070                 1075                 1080             


Leu Asn  His Val Ser Asn Lys  Thr Thr Ser Ser Lys  Asn Met Glu 
    1085                 1090                 1095             


Met Val  His Gln Lys Lys Glu  Gly Pro Val Pro Pro  Asp Ala Glu 
    1100                 1105                 1110             


Asn Pro  Asp Met Ser Phe Phe  Lys Met Leu Phe Leu  Pro Glu Ser 
    1115                 1120                 1125             


Ala Asn  Trp Ile Lys Arg Thr  His Gly Lys Asn Ser  Leu Asn Ser 
    1130                 1135                 1140             


Gly Gln  Gly Pro Ser Pro Lys  Gln Leu Ile Ser Leu  Gly Ser Glu 
    1145                 1150                 1155             


Lys Ser  Val Lys Asp Gln Asn  Phe Leu Ser Glu Lys  Asn Lys Val 
    1160                 1165                 1170             


Val Val  Gly Glu Asp Glu Phe  Thr Lys Asp Thr Gly  Leu Lys Glu 
    1175                 1180                 1185             


Met Ile  Phe Pro Asn Asn Arg  Ser Ile Phe Leu Thr  Asn Leu Ala 
    1190                 1195                 1200             


Asn Val  Gln Glu Asn Asp Thr  His Asn Gln Glu Lys  Lys Phe Gln 
    1205                 1210                 1215             


Glu Glu  Ile Glu Arg Lys Glu  Ala Leu Ile Gln Glu  Asn Val Val 
    1220                 1225                 1230             


Leu Pro  Gln Val Tyr Thr Val  Thr Gly Thr Lys Asn  Phe Leu Lys 
    1235                 1240                 1245             


Asn Leu  Phe Leu Leu Ser Thr  Arg Gln Asn Ile Gly  Leu Asp Glu 
    1250                 1255                 1260             


Gly Thr  Tyr Ala Pro Val Leu  Gln Asp Thr Arg Ser  Leu Asn Asp 
    1265                 1270                 1275             


Ser Thr  Asn Arg Ala Glu Ile  His Met Ala His Phe  Ser Lys Arg 
    1280                 1285                 1290             


Arg Glu  Glu Glu Glu Thr Asn  Leu Glu Gly Leu Gly  Asn Gln Thr 
    1295                 1300                 1305             


Lys Gln  Met Val Glu Lys Tyr  Pro Ser Thr Thr Arg  Met Ser Pro 
    1310                 1315                 1320             


Asn Pro  Ser Gln Gln Asn Val  Ile Thr Gln Arg Gly  Lys Arg Ala 
    1325                 1330                 1335             


Leu Lys  Gln Phe Arg Leu Pro  Leu Glu Glu Thr Glu  Leu Glu Lys 
    1340                 1345                 1350             


Gly Leu  Ile Val Asp Asp Thr  Ser Thr Gln Trp Ser  Lys Asn Met 
    1355                 1360                 1365             


Lys Tyr  Leu Thr Gln Ser Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu 
    1370                 1375                 1380             


Lys Glu  Lys Lys Ala Ile Thr  Gln Ser Pro Leu Ser  Asp Ser Pro 
    1385                 1390                 1395             


Met Arg  Asn His Ser Ile Thr  Gln Met Asn Ser Ser  Ala Leu Pro 
    1400                 1405                 1410             


Ile Ala  Lys Ile Ser Ala Phe  Pro Ser Ile Arg Pro  Thr Asp Leu 
    1415                 1420                 1425             


Thr Lys  Ile Pro Ser Gln Asp  Asn Ser Ser His Phe  Leu Ala Ser 
    1430                 1435                 1440             


Ala Tyr  Asn Tyr Thr Phe Arg  Glu Lys Ser Ser Gly  Val Gln Glu 
    1445                 1450                 1455             


Ser Ser  His Phe Leu Gln Gly  Ala Lys Arg Asn Asn  Leu Ser Leu 
    1460                 1465                 1470             


Ala Ile  Leu Pro Leu Glu Met  Ile Arg Asn Gln Glu  Lys Val Gly 
    1475                 1480                 1485             


Ser Leu  Gly Thr Ser Ala Thr  Asn Ser Val Met Tyr  Lys Lys Leu 
    1490                 1495                 1500             


Glu Asn  Thr Val Leu Leu Lys  Pro Gly Leu Pro Glu  Ala Ser Gly 
    1505                 1510                 1515             


Lys Val  Glu Leu Leu Pro Lys  Val Pro Ile His Gln  Glu Asp Leu 
    1520                 1525                 1530             


Phe Pro  Thr Glu Thr Ser His  Gly Ser Pro Gly His  Leu Asp Leu 
    1535                 1540                 1545             


Met Glu  Glu Ile Leu Leu Gln  Lys Thr Gln Gly Ala  Ile Lys Trp 
    1550                 1555                 1560             


Asn Lys  Thr Asn Arg Pro Gly  Lys Val Pro Phe Leu  Lys Gly Ala 
    1565                 1570                 1575             


Thr Glu  Ser Ser Glu Lys Thr  Pro Ser Lys Leu Leu  Gly Pro Leu 
    1580                 1585                 1590             


Ala Trp  Asp Asn Gln Tyr Ala  Thr Gln Ile Pro Lys  Glu Glu Trp 
    1595                 1600                 1605             


Lys Ser  Gln Glu Lys Ser Pro  Lys Asn Thr Ala Phe  Lys Thr Lys 
    1610                 1615                 1620             


Asp Thr  Ile Leu Ser Leu Asn  Pro Cys Glu Asn Asn  His Ala Ile 
    1625                 1630                 1635             


Ala Ala  Ile Asn Glu Gly Gln  Asp Arg Pro Gln Arg  Glu Ala Thr 
    1640                 1645                 1650             


Trp Ala  Lys Gln Gly Gly Thr  Gly Arg Leu Cys Ser  Gln Asn Pro 
    1655                 1660                 1665             


Pro Val  Leu Lys Arg His Gln  Arg Glu Ile Thr Leu  Thr Thr Leu 
    1670                 1675                 1680             


Gln Ser  Glu Gln Glu Glu Ile  Asp Tyr Asp Asp Thr  Ile Ser Ile 
    1685                 1690                 1695             


Glu Thr  Lys Arg Glu Asp Phe  Asp Ile Tyr Gly Glu  Asp Glu Asn 
    1700                 1705                 1710             


Gln Gly  Pro Arg Ser Phe Gln  Lys Arg Thr Arg His  Tyr Phe Ile 
    1715                 1720                 1725             


Ala Ala  Val Glu Arg Leu Trp  Asp Tyr Gly Met Ser  Arg Ser Pro 
    1730                 1735                 1740             


His Val  Leu Arg Asn Arg Asp  Gln Ser Gly Ser Val  Pro Gln Phe 
    1745                 1750                 1755             


Lys Lys  Val Val Phe Gln Glu  Phe Thr Asp Gly Ser  Phe Thr Gln 
    1760                 1765                 1770             


Pro Leu  Tyr Arg Gly Glu Leu  Asn Glu His Leu Gly  Leu Leu Gly 
    1775                 1780                 1785             


Pro Tyr  Ile Arg Ala Glu Val  Glu Asp Asn Ile Met  Val Thr Phe 
    1790                 1795                 1800             


Lys Asn  Gln Ala Ser Arg Pro  Tyr Ser Phe Tyr Ser  Ser Leu Ile 
    1805                 1810                 1815             


Ser Tyr  Lys Glu Asp Gln Arg  Gln Gly Ala Glu Pro  Arg Lys Asn 
    1820                 1825                 1830             


Phe Val  Lys Pro Asn Glu Thr  Lys Thr Tyr Phe Trp  Lys Val Gln 
    1835                 1840                 1845             


His His  Met Ala Pro Thr Lys  Asp Glu Phe Asp Cys  Lys Ala Trp 
    1850                 1855                 1860             


Ala Tyr  Phe Ser Asp Val Asp  Leu Glu Lys Asp Met  His Ser Gly 
    1865                 1870                 1875             


Leu Ile  Gly Pro Leu Leu Ile  Cys His Thr Asn Thr  Leu Asn Pro 
    1880                 1885                 1890             


Ala His  Gly Arg Gln Val Thr  Val Gln Glu Phe Ala  Leu Phe Phe 
    1895                 1900                 1905             


Thr Ile  Phe Asp Glu Thr Lys  Ser Trp Tyr Phe Thr  Glu Asn Met 
    1910                 1915                 1920             


Glu Arg  Asn Cys Arg Ala Pro  Cys Asn Ile Gln Met  Glu Asp Pro 
    1925                 1930                 1935             


Thr Phe  Lys Glu Asn Tyr Arg  Phe His Ala Ile Asn  Gly Tyr Val 
    1940                 1945                 1950             


Met Asp  Thr Leu Pro Gly Leu  Val Met Ala Gln Asp  Gln Arg Ile 
    1955                 1960                 1965             


Arg Trp  Tyr Leu Leu Ser Met  Gly Ser Asn Glu Asn  Ile His Ser 
    1970                 1975                 1980             


Ile His  Phe Ser Gly His Val  Phe Thr Val Arg Lys  Lys Glu Glu 
    1985                 1990                 1995             


Tyr Lys  Met Ala Val Tyr Asn  Leu Tyr Pro Gly Val  Phe Glu Thr 
    2000                 2005                 2010             


Val Glu  Met Leu Pro Ser Lys  Ala Gly Ile Trp Arg  Val Glu Cys 
    2015                 2020                 2025             


Leu Ile  Gly Glu His Leu His  Ala Gly Met Ser Thr  Leu Phe Leu 
    2030                 2035                 2040             


Val Tyr  Ser Lys Gln Cys Gln  Ile Pro Leu Gly Met  Ala Ser Gly 
    2045                 2050                 2055             


His Ile  Arg Asp Phe Gln Ile  Thr Ala Ser Gly Gln  Tyr Gly Gln 
    2060                 2065                 2070             


Trp Ala  Pro Lys Leu Ala Arg  Leu His Tyr Ser Gly  Ser Ile Asn 
    2075                 2080                 2085             


Ala Trp  Ser Thr Lys Glu Pro  Phe Ser Trp Ile Lys  Val Asp Leu 
    2090                 2095                 2100             


Leu Ala  Pro Met Ile Ile His  Gly Ile Lys Thr Gln  Gly Ala Arg 
    2105                 2110                 2115             


Gln Lys  Phe Ser Ser Leu Tyr  Ile Ser Gln Phe Ile  Ile Met Tyr 
    2120                 2125                 2130             


Ser Leu  Asp Gly Lys Lys Trp  Gln Thr Tyr Arg Gly  Asn Ser Thr 
    2135                 2140                 2145             


Gly Thr  Leu Met Val Phe Phe  Gly Asn Val Asp Ser  Ser Gly Ile 
    2150                 2155                 2160             


Lys His  Asn Ile Phe Asn Pro  Pro Ile Ile Ala Arg  Tyr Ile Arg 
    2165                 2170                 2175             


Leu His  Pro Thr His Tyr Ser  Ile Arg Ser Thr Leu  Arg Met Glu 
    2180                 2185                 2190             


Leu Met  Gly Cys Asp Leu Asn  Ser Cys Ser Met Pro  Leu Gly Met 
    2195                 2200                 2205             


Glu Ser  Lys Ala Ile Ser Asp  Ala Gln Ile Thr Ala  Ser Ser Tyr 
    2210                 2215                 2220             


Phe Thr  Asn Met Phe Ala Thr  Trp Ser Pro Ser Gln  Ala Arg Leu 
    2225                 2230                 2235             


His Leu  Gln Gly Arg Thr Asn  Ala Trp Arg Pro Gln  Val Asn Asn 
    2240                 2245                 2250             


Pro Lys  Glu Trp Leu Gln Val  Asp Phe Gln Lys Thr  Met Lys Val 
    2255                 2260                 2265             


Thr Gly  Ile Ile Thr Gln Gly  Val Lys Ser Leu Leu  Thr Ser Met 
    2270                 2275                 2280             


Phe Val  Lys Glu Phe Leu Ile  Ser Ser Ser Gln Asp  Gly His His 
    2285                 2290                 2295             


Trp Thr  Leu Phe Leu Gln Asn  Gly Lys Val Lys Val  Phe Gln Gly 
    2300                 2305                 2310             


Asn Gln  Asp Ser Phe Thr Pro  Val Val Asn Ser Leu  Asp Pro Pro 
    2315                 2320                 2325             


Leu Leu  Thr Arg Tyr Leu Arg  Ile His Pro Gln Ser  Trp Val His 
    2330                 2335                 2340             


Gln Ile  Ala Leu Arg Leu Glu  Val Leu Gly Cys Glu  Ala Gln Gln 
    2345                 2350                 2355             


Leu Tyr  
    2360 


<210>  34
<211>  2357
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  34

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Glu Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Arg Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Ile Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Asn Glu Ser Leu Thr Gln Ala Met 
225                 230                 235                 240 


Asp Pro Ala Ser Ala Arg Ala Gln Pro Glu Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Tyr Asp Ser Asp Met Asp Val Val Arg Phe Asp Asp Asp Asn 
    370                 375                 380                 


Ser Pro Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Pro Asn Asp Arg Ser Tyr Lys Ser Leu Tyr Leu 
            420                 425                 430         


Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Ser Pro Leu His Ser Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Met Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Leu Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Asp Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Val Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Arg Asn Thr Gly 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Pro Thr Ser Leu Leu Asn 
            740                 745                 750         


Glu Asn Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
        755                 760                 765             


Pro Ser Thr Arg Gln Lys Gln Phe Lys Ala Thr Thr Thr Pro Glu Asn 
    770                 775                 780                 


Asp Ile Glu Lys Ile Asp Pro Gln Ser Gly Glu Arg Thr Gln Leu Leu 
785                 790                 795                 800 


Lys Val Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Asn Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Thr 
            820                 825                 830         


Tyr Glu Ala Asp Asp His Leu Pro Gly Ala Ile Glu Arg Asn Lys Gly 
        835                 840                 845             


Pro Ser Glu Val Ala His Leu Arg Pro Glu Leu His His Ser Gly Asp 
    850                 855                 860                 


Arg Val Phe Thr Pro Glu Pro Glu Leu Gln Leu Arg Leu Asn Glu Asn 
865                 870                 875                 880 


Leu Gly Thr Thr Ile Thr Val Glu Leu Lys Lys Leu Asp Leu Lys Ile 
                885                 890                 895     


Ser Ser Ser Ser Asn Asn Leu Met Thr Ser Pro Thr Ile Pro Ser Asp 
            900                 905                 910         


Lys Leu Ala Ala Gly Thr Glu Lys Thr Gly Ser Leu Gly Pro Pro Asn 
        915                 920                 925             


Met Pro Val His Phe Ser Ser Gln Leu Gly Thr Ile Val Phe Gly Lys 
    930                 935                 940                 


Asn Ser Ser His Leu Ile Gly Ser Gly Val Pro Leu Gly Leu Ser Glu 
945                 950                 955                 960 


Gly Asp Asn Asp Ser Lys Leu Leu Glu Ala Ala Leu Met Asn Ser Gln 
                965                 970                 975     


Glu Ser Ser Leu Gly Glu Asn Val Leu Ser Met Glu Ser Asp Arg Leu 
            980                 985                 990         


Phe Lys Glu Glu Arg Val His Gly  Pro Ala Ser Leu Thr  Lys Asp Asn 
        995                 1000                 1005             


Ala Leu  Phe Lys Val Asn Ile  Ser Leu Val Lys Thr  Asn Lys Ala 
    1010                 1015                 1020             


Pro Ile  Asn Ser Thr Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro 
    1025                 1030                 1035             


Thr Leu  Leu Ile Glu Asn Ser  Thr Ser Val Trp Gln  Asp Ile Ile 
    1040                 1045                 1050             


Leu Glu  Ser Asn Thr Glu Phe  Gln Glu Val Thr Ser  Leu Ile His 
    1055                 1060                 1065             


Asp Glu  Thr Phe Met Asp Lys  Asn Thr Thr Ala Leu  Gly Leu Asn 
    1070                 1075                 1080             


His Val  Ser Asn Lys Thr Thr  Ser Ser Lys Asn Met  Glu Met Val 
    1085                 1090                 1095             


His Gln  Lys Lys Glu Gly Pro  Val Pro Leu Gly Ala  Glu Asn Pro 
    1100                 1105                 1110             


Asp Thr  Ser Phe Phe Lys Met  Leu Phe Leu Pro Asp  Ser Ala Asn 
    1115                 1120                 1125             


Trp Ile  Lys Arg Thr His Gly  Lys Asn Ser Leu Ser  Ser Gly Gln 
    1130                 1135                 1140             


Arg Pro  Ser Pro Lys Gln Leu  Thr Ser Leu Gly Ser  Glu Lys Ser 
    1145                 1150                 1155             


Val Lys  Asp Gln Asn Phe Leu  Ser Glu Lys Asn Lys  Val Val Val 
    1160                 1165                 1170             


Gly Glu  Asp Glu Phe Thr Lys  Asp Thr Gly Leu Lys  Glu Met Ile 
    1175                 1180                 1185             


Phe Pro  Asn Ser Lys Ser Ile  Phe Leu Thr Asn Leu  Ala Asn Val 
    1190                 1195                 1200             


Gln Glu  Asn Asp Thr His Asn  Gln Glu Lys Lys Ser  Gln Glu Glu 
    1205                 1210                 1215             


Ile Glu  Arg Lys Glu Lys Leu  Ile Gln Glu Asn Val  Val Leu Pro 
    1220                 1225                 1230             


Gln Val  Tyr Thr Val Thr Gly  Thr Lys Asn Phe Leu  Lys Asn Leu 
    1235                 1240                 1245             


Phe Leu  Leu Ser Thr Lys Gln  Asn Val Glu Gly Leu  Asp Glu Gly 
    1250                 1255                 1260             


Thr Tyr  Thr Pro Ile Leu Gln  Asp Thr Arg Ser Leu  Asn Asp Ser 
    1265                 1270                 1275             


Ala Asn  Arg Ala Gly Ile His  Met Ala His Phe Ser  Lys Ile Arg 
    1280                 1285                 1290             


Glu Glu  Ala Asn Leu Glu Gly  Leu Gly Asn Gln Thr  Lys Gln Met 
    1295                 1300                 1305             


Val Glu  Lys Tyr Pro Ser Thr  Thr Arg Met Ser Pro  Asn Pro Ser 
    1310                 1315                 1320             


Gln Gln  Asn Val Ile Thr Gln  Arg Gly Lys Arg Ala  Leu Lys Gln 
    1325                 1330                 1335             


Phe Arg  Leu Pro Leu Glu Glu  Ile Lys Leu Glu Arg  Gly Val Ile 
    1340                 1345                 1350             


Leu Asn  Asp Thr Ser Thr Gln  Trp Ser Lys Asn Met  Lys Tyr Leu 
    1355                 1360                 1365             


Thr Gln  Gly Thr Leu Thr Gln  Ile Glu Tyr Asn Glu  Lys Glu Lys 
    1370                 1375                 1380             


Arg Ala  Ile Thr Gln Ser Leu  Leu Ser Asp Cys Ser  Met Arg Ser 
    1385                 1390                 1395             


His Gly  Ile Ile Gln Thr Asn  Gly Ser Ala Leu Pro  Ile Ala Lys 
    1400                 1405                 1410             


Val Ser  Ala Phe Pro Ser Ile  Arg Pro Thr Asp Leu  Thr Lys Ile 
    1415                 1420                 1425             


Pro Ser  Gln Asp Asn Ser Ser  His Leu Leu Ala Ser  Ala Cys Ser 
    1430                 1435                 1440             


Tyr Thr  Phe Arg Glu Arg Ser  Ser Gly Val Gln Glu  Ser Ser His 
    1445                 1450                 1455             


Phe Leu  Gln Gly Ala Lys Arg  Asn Asn Leu Ser Leu  Ala Phe Leu 
    1460                 1465                 1470             


Thr Leu  Glu Met Ile Arg Gly  Gln Glu Lys Ile Ser  Ser Leu Gly 
    1475                 1480                 1485             


Lys Ser  Ala Thr Asn Pro Leu  Met Tyr Lys Lys Leu  Glu Asn Thr 
    1490                 1495                 1500             


Val Leu  Leu Lys Pro Gly Leu  Ser Glu Ala Ser Gly  Lys Val Glu 
    1505                 1510                 1515             


Leu Leu  Pro Lys Val His Val  His Gln Glu Asp Ser  Phe Pro Thr 
    1520                 1525                 1530             


Lys Thr  Ser Asn Gly Ser Pro  Gly His Leu Asp Leu  Met Glu Glu 
    1535                 1540                 1545             


Ile Phe  Leu Gln Lys Thr Gln  Gly Pro Val Lys Leu  Asn Lys Val 
    1550                 1555                 1560             


Asn Arg  Pro Gly Lys Val Pro  Phe Leu Lys Trp Ala  Thr Glu Ser 
    1565                 1570                 1575             


Ser Glu  Lys Thr Pro Ser Lys  Leu Leu Gly Pro Leu  Ala Trp Asp 
    1580                 1585                 1590             


Asn Gln  Tyr Ala Thr Gln Ile  Pro Arg Glu Glu Trp  Lys Ser Gln 
    1595                 1600                 1605             


Glu Lys  Ser Gln Lys Asn Thr  Ala Phe Lys Thr Lys  Asp Thr Ile 
    1610                 1615                 1620             


Leu Pro  Leu Asp Pro Cys Glu  Asn Asn His Ser Ile  Ala Ala Ile 
    1625                 1630                 1635             


Asn Glu  Gly Gln Asp Lys Pro  Gln Arg Glu Ala Thr  Trp Ala Lys 
    1640                 1645                 1650             


Gln Gly  Gly Thr Gly Arg Leu  Cys Ser Gln Asn Pro  Pro Val Leu 
    1655                 1660                 1665             


Lys Arg  His Gln Arg Glu Ile  Thr Leu Thr Thr Leu  Gln Pro Glu 
    1670                 1675                 1680             


Glu Asp  Lys Ile Asp Tyr Asp  Asp Thr Phe Ser Ile  Glu Thr Lys 
    1685                 1690                 1695             


Arg Glu  Asp Phe Asp Ile Tyr  Gly Glu Asp Glu Asn  Gln Gly Pro 
    1700                 1705                 1710             


Arg Ser  Phe Gln Lys Arg Thr  Arg His Tyr Phe Ile  Ala Ala Val 
    1715                 1720                 1725             


Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Arg Ser Pro  His Ala Leu 
    1730                 1735                 1740             


Arg Asn  Arg Ala Gln Ser Gly  Ser Val Pro Gln Phe  Lys Lys Val 
    1745                 1750                 1755             


Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr 
    1760                 1765                 1770             


Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile 
    1775                 1780                 1785             


Arg Ala  Glu Val Glu Asp Asn  Ile Met Val Thr Phe  Lys Asn Gln 
    1790                 1795                 1800             


Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu 
    1805                 1810                 1815             


Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg Lys Lys  Phe Val Lys 
    1820                 1825                 1830             


Pro Asn  Glu Thr Lys Ile Tyr  Phe Trp Lys Val Gln  His His Met 
    1835                 1840                 1845             


Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe 
    1850                 1855                 1860             


Ser Asp  Val Asp Leu Glu Lys  Asp Met His Ser Gly  Leu Ile Gly 
    1865                 1870                 1875             


Pro Leu  Leu Ile Cys Arg Thr  Asn Thr Leu Asn Pro  Ala His Gly 
    1880                 1885                 1890             


Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 
    1895                 1900                 1905             


Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 
    1910                 1915                 1920             


Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 
    1925                 1930                 1935             


Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Val  Met Asp Thr 
    1940                 1945                 1950             


Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 
    1955                 1960                 1965             


Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 
    1970                 1975                 1980             


Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 
    1985                 1990                 1995             


Ala Val  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 
    2000                 2005                 2010             


Leu Pro  Ser Lys Ala Gly Ile  Trp Arg Ile Glu Cys  Leu Ile Gly 
    2015                 2020                 2025             


Glu His  Leu Gln Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 
    2030                 2035                 2040             


Lys Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  Arg Ile Arg 
    2045                 2050                 2055             


Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 
    2060                 2065                 2070             


Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 
    2075                 2080                 2085             


Thr Lys  Asp Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 
    2090                 2095                 2100             


Met Ile  Ile His Ser Ile Met  Thr Gln Gly Ala Arg  Gln Lys Phe 
    2105                 2110                 2115             


Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 
    2120                 2125                 2130             


Gly Lys  Lys Trp Gln Ser Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 
    2135                 2140                 2145             


Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 
    2150                 2155                 2160             


Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 
    2165                 2170                 2175             


Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 
    2180                 2185                 2190             


Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Asn Lys 
    2195                 2200                 2205             


Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser Tyr  Leu Asn Asn 
    2210                 2215                 2220             


Met Phe  Ala Thr Trp Ser Pro  Ser Gln Ala Arg Leu  His Leu Gln 
    2225                 2230                 2235             


Gly Arg  Thr Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 
    2240                 2245                 2250             


Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Ile 
    2255                 2260                 2265             


Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 
    2270                 2275                 2280             


Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Asn  Trp Thr Leu 
    2285                 2290                 2295             


Phe Leu  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 
    2300                 2305                 2310             


Ser Phe  Thr Pro Val Val Asn  Ser Leu Asp Pro Pro  Leu Leu Thr 
    2315                 2320                 2325             


Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Ala His  Gln Ile Ala 
    2330                 2335                 2340             


Leu Arg  Leu Glu Val Leu Gly  Cys Glu Ala Gln Gln  Leu Tyr 
    2345                 2350                 2355         


<210>  35
<211>  2357
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  35

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Phe Ser Ala Ile Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Glu Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp Gln Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Gln Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ser 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Ile Pro Gly Lys Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Thr Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Thr Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Gly Lys Asn Glu Ser Leu Thr Gln Ala Met 
225                 230                 235                 240 


Asp Pro Ala Ser Ala Arg Ala Gln Pro Ala Met His Thr Ile Asn Gly 
                245                 250                 255     


Tyr Ile Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Tyr Asp Ser Asp Met Asp Val Val Arg Phe Asp Gly Asp Asn 
    370                 375                 380                 


Ala Pro Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Ser Asn Asp Arg Ser Tyr Lys Ser Leu Tyr Leu 
            420                 425                 430         


Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Ile Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Ser Pro Leu His Ser Gly Arg Phe Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Met Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Leu Glu 
545                 550                 555                 560 


Lys Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Gln Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Ile Gln Arg Phe Leu Pro Asn Ala Asp Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Val Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Tyr Ser Cys Asp Arg Asn Thr Gly 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Pro Thr Phe Leu Leu Asn 
            740                 745                 750         


Glu Asn Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
        755                 760                 765             


Pro Ser Thr Arg Gln Lys Gln Phe Lys Ala Thr Thr Thr Pro Glu Asn 
    770                 775                 780                 


Asp Ile Glu Lys Ile Asp Pro Gln Ser Gly Glu Arg Thr Gln Leu Leu 
785                 790                 795                 800 


Lys Glu Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Asn Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Arg 
            820                 825                 830         


Asn Glu Ala Asp Asp His Leu Pro Gly Ala Ile Glu Arg Asn Lys Gly 
        835                 840                 845             


Pro Ser Glu Val Ala His Leu Arg Pro Glu Leu His His Ser Gly Glu 
    850                 855                 860                 


Arg Val Phe Thr Pro Glu Pro Glu Leu Pro Leu Arg Leu Asn Glu Asn 
865                 870                 875                 880 


Leu Gly Thr Thr Ile Thr Val Glu Leu Lys Lys Leu Asp Phe Lys Ile 
                885                 890                 895     


Ser Ser Ser Ser Asn Asn Leu Met Thr Ser Pro Thr Ile Pro Ser Asp 
            900                 905                 910         


Lys Leu Ser Ala Gly Thr Glu Lys Thr Gly Ser Leu Gly Pro Pro Asn 
        915                 920                 925             


Met Pro Val Asn Phe Ser Ser Gln Leu Gly Thr Ile Val Phe Gly Lys 
    930                 935                 940                 


Asn Ser Ser His Phe Ile Gly Ser Gly Val Pro Leu Gly Leu Ser Glu 
945                 950                 955                 960 


Glu Asp Asn Asp Ser Lys Leu Leu Glu Ala Ala Leu Met Asn Ser Gln 
                965                 970                 975     


Glu Ser Ser Leu Gly Glu Asn Val Leu Ser Met Glu Ser Asp Arg Leu 
            980                 985                 990         


Phe Lys Glu Glu Arg Val His Gly  Pro Ala Ser Leu Thr  Lys Asp Asp 
        995                 1000                 1005             


Ala Leu  Phe Lys Val Asn Ile  Ser Leu Val Lys Thr  Asn Lys Ala 
    1010                 1015                 1020             


Pro Val  Asn Ser Thr Thr Asn  Arg Lys Thr His Ile  Asp Asp Pro 
    1025                 1030                 1035             


Thr Leu  Leu Ile Glu Asn Ser  Thr Ser Val Trp Gln  Asp Ile Ile 
    1040                 1045                 1050             


Leu Glu  Ser Asn Thr Glu Phe  Gln Glu Val Thr Ser  Leu Ile His 
    1055                 1060                 1065             


Asp Glu  Thr Phe Met Asp Lys  Asn Thr Thr Ala Leu  Gly Leu Asn 
    1070                 1075                 1080             


His Val  Ser Asn Lys Thr Thr  Ser Ser Lys Asn Met  Glu Met Val 
    1085                 1090                 1095             


His Gln  Lys Lys Glu Gly Pro  Val Pro Leu Asp Ala  Glu Tyr Pro 
    1100                 1105                 1110             


Asp Thr  Ser Phe Phe Lys Thr  Leu Phe Leu Pro Asp  Ser Thr Asn 
    1115                 1120                 1125             


Trp Ile  Lys Arg Thr His Gly  Lys Asn Ser Leu Ser  Ser Gly Gln 
    1130                 1135                 1140             


Arg Pro  Ser Pro Lys Gln Leu  Thr Ser Ser Gly Ser  Glu Lys Ser 
    1145                 1150                 1155             


Val Lys  Asp Gln Asn Phe Leu  Ser Glu Lys Asn Lys  Val Val Val 
    1160                 1165                 1170             


Gly Glu  Asp Glu Phe Ser Lys  Asp Thr Gly Leu Lys  Glu Met Ile 
    1175                 1180                 1185             


Phe Pro  Asn Ser Lys Ser Ile  Phe Leu Thr Asn Leu  Ala Asn Val 
    1190                 1195                 1200             


Gln Glu  Asn Asp Thr His Asn  Gln Glu Lys Lys Ser  Gln Glu Glu 
    1205                 1210                 1215             


Ile Glu  Arg Lys Glu Lys Leu  Ile Gln Glu Asn Val  Val Leu Pro 
    1220                 1225                 1230             


Gln Val  Tyr Thr Val Thr Gly  Thr Lys Asn Phe Leu  Lys Asn Leu 
    1235                 1240                 1245             


Phe Leu  Leu Ser Thr Lys Gln  Asn Val Glu Gly Leu  Asp Glu Gly 
    1250                 1255                 1260             


Thr Tyr  Thr Pro Val Leu Gln  Asp Thr Arg Ser Leu  Asn Asp Ser 
    1265                 1270                 1275             


Ala Lys  Arg Ala Gly Ile His  Met Ala His Phe Ser  Lys Ile Arg 
    1280                 1285                 1290             


Glu Glu  Ala Asn Leu Glu Gly  Leu Gly Asn Gln Thr  Lys Gln Met 
    1295                 1300                 1305             


Val Glu  Lys Tyr Pro Ser Thr  Thr Arg Met Ser Pro  Asn Pro Ser 
    1310                 1315                 1320             


Gln Gln  Asn Val Ile Pro Gln  Arg Gly Lys Arg Asp  Leu Lys Gln 
    1325                 1330                 1335             


Phe Arg  Leu Pro Leu Glu Glu  Ile Lys Leu Glu Arg  Gly Val Ile 
    1340                 1345                 1350             


Leu Asn  Asp Thr Ser Thr Gln  Trp Ser Lys Asn Met  Lys Tyr Leu 
    1355                 1360                 1365             


Thr Gln  Gly Thr Phe Thr Gln  Ile Glu Tyr Asn Lys  Lys Glu Lys 
    1370                 1375                 1380             


Arg Ala  Ile Thr Gln Ser Phe  Leu Ser Asp Cys Ser  Met Arg Ser 
    1385                 1390                 1395             


His Gly  Ile Ile Gln Thr Asn  Gly Ser Ala Leu Pro  Ile Ala Lys 
    1400                 1405                 1410             


Val Ser  Ala Phe Pro Ser Ile  Arg Pro Thr Asp Leu  Thr Lys Ile 
    1415                 1420                 1425             


Pro Ser  Gln Asp Asn Ser Ser  His Leu Pro Ala Ser  Ala Cys Ser 
    1430                 1435                 1440             


Tyr Thr  Phe Gly Glu Arg Ser  Ser Gly Val Gln Glu  Ser Ser His 
    1445                 1450                 1455             


Phe Leu  Gln Gly Ala Lys Arg  Asn Asn Leu Ser Leu  Ala Phe Leu 
    1460                 1465                 1470             


Thr Leu  Glu Met Ile Arg Gly  Gln Gly Lys Ile Ser  Thr Leu Gly 
    1475                 1480                 1485             


Lys Ser  Ala Thr Asn Pro Leu  Met Tyr Lys Lys Leu  Glu Asn Thr 
    1490                 1495                 1500             


Val Leu  Leu Lys Pro Gly Leu  Ser Glu Ala Ser Gly  Lys Val Glu 
    1505                 1510                 1515             


Phe Leu  Pro Lys Val His Val  His Gln Glu Asp Phe  Phe Pro Thr 
    1520                 1525                 1530             


Lys Thr  Ser Asn Gly Ser Pro  Ala His Leu Asp Leu  Arg Glu Glu 
    1535                 1540                 1545             


Ile Phe  Leu Gln Lys Thr Gln  Gly Leu Val Lys Leu  Asn Lys Val 
    1550                 1555                 1560             


Asn Arg  Pro Gly Lys Val Pro  Phe Leu Lys Trp Ala  Thr Glu Ser 
    1565                 1570                 1575             


Ser Glu  Lys Thr Pro Ser Lys  Leu Leu Gly Pro Leu  Ala Trp Asp 
    1580                 1585                 1590             


Asn Gln  Tyr Ala Thr Leu Ile  Pro Arg Glu Glu Trp  Lys Ser Leu 
    1595                 1600                 1605             


Glu Lys  Ser Gln Lys Asn Thr  Ala Phe Lys Thr Lys  Asp Thr Ile 
    1610                 1615                 1620             


Leu Pro  Leu Asp Pro Cys Glu  Asn Asn His Ser Ile  Ala Ala Ile 
    1625                 1630                 1635             


Asn Glu  Gly Gln Asp Lys Pro  Gln Arg Glu Ala Thr  Trp Val Lys 
    1640                 1645                 1650             


Gln Gly  Gly Thr Gly Arg Leu  Cys Ser Gln Asn Pro  Pro Val Leu 
    1655                 1660                 1665             


Lys Arg  His Gln Arg Glu Ile  Thr Leu Thr Thr Phe  Gln Pro Glu 
    1670                 1675                 1680             


Glu Asp  Lys Ile Asp Tyr Asp  Asp Thr Phe Ser Ile  Glu Thr Lys 
    1685                 1690                 1695             


Arg Glu  Asp Phe Asp Ile Tyr  Gly Glu Asp Glu Asn  Gln Gly Pro 
    1700                 1705                 1710             


Arg Ser  Phe Gln Lys Arg Thr  Arg His Tyr Phe Ile  Ala Ala Val 
    1715                 1720                 1725             


Glu Arg  Leu Trp Asp Tyr Gly  Met Ser Arg Ser Pro  His Ala Leu 
    1730                 1735                 1740             


Arg Asn  Arg Ala Gln Asn Gly  Asp Val Pro Gln Phe  Lys Lys Val 
    1745                 1750                 1755             


Val Phe  Gln Glu Phe Thr Asp  Gly Ser Phe Thr Gln  Pro Leu Tyr 
    1760                 1765                 1770             


Arg Gly  Glu Leu Asn Glu His  Leu Gly Leu Leu Gly  Pro Tyr Ile 
    1775                 1780                 1785             


Arg Ala  Glu Val Glu Asp Asn  Ile Met Val Thr Phe  Lys Asn Gln 
    1790                 1795                 1800             


Ala Ser  Arg Pro Tyr Ser Phe  Tyr Ser Ser Leu Ile  Ser Tyr Glu 
    1805                 1810                 1815             


Glu Asp  Gln Arg Gln Gly Ala  Glu Pro Arg Lys Lys  Phe Val Lys 
    1820                 1825                 1830             


Pro Asn  Glu Thr Lys Ile Tyr  Phe Trp Lys Val Gln  His His Met 
    1835                 1840                 1845             


Ala Pro  Thr Lys Asp Glu Phe  Asp Cys Lys Ala Trp  Ala Tyr Phe 
    1850                 1855                 1860             


Ser Asp  Val Asp Leu Glu Lys  Asp Val His Ser Gly  Leu Ile Gly 
    1865                 1870                 1875             


Pro Leu  Leu Ile Cys Arg Thr  Asn Thr Leu Asn Ala  Ala His Gly 
    1880                 1885                 1890             


Arg Gln  Val Thr Val Gln Glu  Phe Ala Leu Phe Phe  Thr Ile Phe 
    1895                 1900                 1905             


Asp Glu  Thr Lys Ser Trp Tyr  Phe Thr Glu Asn Met  Glu Arg Asn 
    1910                 1915                 1920             


Cys Arg  Ala Pro Cys Asn Ile  Gln Met Glu Asp Pro  Thr Phe Lys 
    1925                 1930                 1935             


Glu Asn  Tyr Arg Phe His Ala  Ile Asn Gly Tyr Val  Met Asp Thr 
    1940                 1945                 1950             


Leu Pro  Gly Leu Val Met Ala  Gln Asp Gln Arg Ile  Arg Trp Tyr 
    1955                 1960                 1965             


Leu Leu  Ser Met Gly Ser Asn  Glu Asn Ile His Ser  Ile His Phe 
    1970                 1975                 1980             


Ser Gly  His Val Phe Thr Val  Arg Lys Lys Glu Glu  Tyr Lys Met 
    1985                 1990                 1995             


Ala Val  Tyr Asn Leu Tyr Pro  Gly Val Phe Glu Thr  Val Glu Met 
    2000                 2005                 2010             


Leu Pro  Ser Lys Val Gly Ile  Trp Arg Ile Glu Cys  Leu Ile Gly 
    2015                 2020                 2025             


Glu His  Leu Gln Ala Gly Met  Ser Thr Leu Phe Leu  Val Tyr Ser 
    2030                 2035                 2040             


Lys Lys  Cys Gln Thr Pro Leu  Gly Met Ala Ser Gly  Arg Ile Arg 
    2045                 2050                 2055             


Asp Phe  Gln Ile Thr Ala Ser  Gly Gln Tyr Gly Gln  Trp Ala Pro 
    2060                 2065                 2070             


Lys Leu  Ala Arg Leu His Tyr  Ser Gly Ser Ile Asn  Ala Trp Ser 
    2075                 2080                 2085             


Thr Lys  Asp Pro Phe Ser Trp  Ile Lys Val Asp Leu  Leu Ala Pro 
    2090                 2095                 2100             


Met Ile  Ile His Ser Ile Met  Thr Gln Gly Ala Arg  Gln Lys Phe 
    2105                 2110                 2115             


Ser Ser  Leu Tyr Ile Ser Gln  Phe Ile Ile Met Tyr  Ser Leu Asp 
    2120                 2125                 2130             


Gly Lys  Lys Trp Gln Ser Tyr  Arg Gly Asn Ser Thr  Gly Thr Leu 
    2135                 2140                 2145             


Met Val  Phe Phe Gly Asn Val  Asp Ser Ser Gly Ile  Lys His Asn 
    2150                 2155                 2160             


Ile Phe  Asn Pro Pro Ile Ile  Ala Arg Tyr Ile Arg  Leu His Pro 
    2165                 2170                 2175             


Thr His  Tyr Ser Ile Arg Ser  Thr Leu Arg Met Glu  Leu Met Gly 
    2180                 2185                 2190             


Cys Asp  Leu Asn Ser Cys Ser  Met Pro Leu Gly Met  Glu Asn Lys 
    2195                 2200                 2205             


Ala Ile  Ser Asp Ala Gln Ile  Thr Ala Ser Ser His  Leu Ser Asn 
    2210                 2215                 2220             


Met Phe  Ala Thr Trp Ser Pro  Ser Gln Ala Arg Leu  His Leu Gln 
    2225                 2230                 2235             


Gly Arg  Thr Asn Ala Trp Arg  Pro Gln Val Asn Asn  Pro Lys Glu 
    2240                 2245                 2250             


Trp Leu  Gln Val Asp Phe Gln  Lys Thr Met Lys Val  Thr Gly Ile 
    2255                 2260                 2265             


Thr Thr  Gln Gly Val Lys Ser  Leu Leu Thr Ser Met  Tyr Val Lys 
    2270                 2275                 2280             


Glu Phe  Leu Ile Ser Ser Ser  Gln Asp Gly His Asn  Trp Thr Leu 
    2285                 2290                 2295             


Phe Leu  Gln Asn Gly Lys Val  Lys Val Phe Gln Gly  Asn Gln Asp 
    2300                 2305                 2310             


Ser Phe  Thr Pro Val Val Asn  Ala Leu Asp Pro Pro  Leu Phe Thr 
    2315                 2320                 2325             


Arg Tyr  Leu Arg Ile His Pro  Gln Ser Trp Ala His  His Ile Ala 
    2330                 2335                 2340             


Leu Arg  Leu Glu Val Leu Gly  Cys Glu Ala Gln Gln  Leu Tyr 
    2345                 2350                 2355         


<210>  36
<211>  2351
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  36

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Glu Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Ser Pro Arg Val Pro Arg Ser Leu Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Arg Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp Gln Thr Ser Gln Lys Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Ile Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Phe Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Lys Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Asn Glu Ser Leu Thr Gln Ser Ala 
225                 230                 235                 240 


Gln Ala Gln His Glu Met His Thr Val Asn Gly Tyr Val Asn Arg Ser 
                245                 250                 255     


Leu Pro Gly Leu Thr Gly Cys His Lys Lys Ser Val Tyr Trp His Val 
            260                 265                 270         


Ile Gly Met Gly Thr Thr Pro Glu Val His Ser Ile Phe Leu Glu Gly 
        275                 280                 285             


His Thr Phe Leu Val Arg Asn His Arg Gln Ala Ser Leu Glu Ile Ser 
    290                 295                 300                 


Pro Ile Thr Phe Leu Thr Ala Gln Thr Phe Leu Met Asp Leu Gly Gln 
305                 310                 315                 320 


Phe Leu Leu Phe Cys His Ile Ser Ser His Gln His Asp Gly Met Glu 
                325                 330                 335     


Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu Pro Gln Leu Arg Met 
            340                 345                 350         


Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp Asp Leu Tyr Asp Ser 
        355                 360                 365             


Asp Met Asp Val Val Arg Phe Asp Gly Asp Asn Ser Ser Pro Phe Ile 
    370                 375                 380                 


Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp Val His Tyr 
385                 390                 395                 400 


Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Ser Ala Pro Thr 
                405                 410                 415     


Pro Asn Asp Arg Ser Tyr Lys Asn Leu Tyr Leu Asn Asn Gly Pro Gln 
            420                 425                 430         


Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala Tyr Thr Asp 
        435                 440                 445             


Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln Tyr Glu Ser Gly Ile Leu 
    450                 455                 460                 


Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu Ile Ile Phe 
465                 470                 475                 480 


Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His Gly Ile Thr 
                485                 490                 495     


Asp Val Ser Pro Leu His Ser Gly Arg Leu Pro Lys Gly Val Lys His 
            500                 505                 510         


Leu Lys Asp Met Pro Ile Leu Pro Gly Glu Ile Phe Lys Tyr Lys Trp 
        515                 520                 525             


Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro Arg Cys Leu 
    530                 535                 540                 


Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu Arg Asp Leu Ala Ser 
545                 550                 555                 560 


Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser Val Asp Gln 
                565                 570                 575     


Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val Ile Leu Phe Ser 
            580                 585                 590         


Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn Met Gln Arg 
        595                 600                 605             


Phe Leu Pro Asn Ala Asp Ala Val Gln Pro His Asp Pro Glu Phe Gln 
    610                 615                 620                 


Val Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe Asp Asn Leu 
625                 630                 635                 640 


Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr Ile Leu Ser 
                645                 650                 655     


Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser Gly Tyr Thr 
            660                 665                 670         


Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu Phe Pro Phe 
        675                 680                 685             


Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly Leu Trp Val 
    690                 695                 700                 


Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met Thr Ala Leu 
705                 710                 715                 720 


Leu Lys Val Ser Ser Cys Asn Arg Asn Thr Gly Asp Tyr Tyr Glu Asp 
                725                 730                 735     


Thr Tyr Glu Asp Ile Pro Thr Ser Leu Leu Asn Glu Asn Asn Val Ile 
            740                 745                 750         


Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His Pro Ser Thr Arg Gln 
        755                 760                 765             


Lys Gln Phe Lys Ala Thr Thr Thr Pro Glu Asn Asp Ile Glu Lys Ile 
    770                 775                 780                 


Asp Pro Gln Ser Gly Glu Arg Thr Gln Leu Leu Lys Val Gln Ser Val 
785                 790                 795                 800 


Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln Asn Pro Thr Pro His 
                805                 810                 815     


Gly Leu Phe Leu Ser Asp Leu Gln Glu Ala Thr His Glu Ala Asp Asp 
            820                 825                 830         


His Leu Leu Gly Ala Ile Glu Arg Asn Lys Gly Pro Ser Glu Val Ala 
        835                 840                 845             


Ser Leu Arg Pro Glu Leu His His Ser Gly Asp Arg Val Phe Thr Pro 
    850                 855                 860                 


Glu Pro Glu Leu Gln Leu Arg Leu Asn Glu Asn Leu Gly Thr Thr Val 
865                 870                 875                 880 


Thr Val Glu Leu Lys Lys Leu Asp Leu Lys Ile Ser Ser Ser Ser Asp 
                885                 890                 895     


Asn Leu Met Thr Ser Pro Thr Ile Pro Ser Asp Lys Leu Ala Ala Gly 
            900                 905                 910         


Thr Glu Lys Thr Gly Ser Leu Gly Pro Pro Asn Met Ser Val His Phe 
        915                 920                 925             


Asn Ser His Leu Gly Thr Ile Val Phe Gly Lys Asn Ser Ser His Leu 
    930                 935                 940                 


Ile Glu Ser Gly Val Pro Leu Gly Leu Ser Glu Gly Asp Asn Asp Ser 
945                 950                 955                 960 


Lys Leu Leu Glu Ala Ala Leu Met Asn Ser Gln Glu Ser Ser Leu Gly 
                965                 970                 975     


Glu Asn Val Leu Ser Met Glu Ser Asn Arg Leu Phe Lys Glu Glu Arg 
            980                 985                 990         


Val His Gly Pro Ala Ser Leu Ile  Lys Asp Asn Ala Leu  Phe Lys Val 
        995                 1000                 1005             


Asn Ile  Ser Leu Val Lys Thr  Asn Lys Ala Pro Ile  Asn Ser Thr 
    1010                 1015                 1020             


Thr Asn  Arg Lys Thr His Val  Asp Val Pro Thr Leu  Leu Ile Glu 
    1025                 1030                 1035             


Asn Ser  Thr Ser Val Trp Gln  Asp Ile Ile Leu Glu  Ser Asn Thr 
    1040                 1045                 1050             


Glu Phe  Gln Glu Val Thr Ser  Leu Ile His Asn Glu  Thr Phe Met 
    1055                 1060                 1065             


Asp Arg  Asn Thr Thr Ala Leu  Gly Leu Asn His Val  Ser Asn Lys 
    1070                 1075                 1080             


Thr Thr  Ser Ser Lys Asn Val  Glu Met Val His Gln  Lys Lys Glu 
    1085                 1090                 1095             


Gly Pro  Val Pro Leu Gly Ala  Glu Asn Pro Asp Leu  Ser Phe Phe 
    1100                 1105                 1110             


Lys Ile  Leu Phe Leu Pro Asp  Ser Ala Asn Trp Ile  Lys Arg Thr 
    1115                 1120                 1125             


His Gly  Lys Asn Ser Leu Ser  Ser Gly Gln Arg Pro  Ser Pro Lys 
    1130                 1135                 1140             


Gln Leu  Thr Ser Leu Gly Ser  Glu Lys Ser Val Lys  Asp Gln Asn 
    1145                 1150                 1155             


Phe Leu  Ser Glu Lys Lys Val  Val Val Gly Glu Asp  Glu Phe Thr 
    1160                 1165                 1170             


Lys Asp  Thr Gly Leu Lys Glu  Met Ile Phe Pro Asn  Ser Lys Ser 
    1175                 1180                 1185             


Ile Phe  Phe Thr Asn Leu Ala  Asn Val Gln Glu Asn  Asp Thr Tyr 
    1190                 1195                 1200             


Asn Gln  Glu Lys Lys Ser Gln  Glu Glu Ile Glu Arg  Lys Glu Lys 
    1205                 1210                 1215             


Leu Thr  Gln Glu Asn Val Val  Leu Pro Gln Val Tyr  Thr Val Thr 
    1220                 1225                 1230             


Gly Thr  Lys Asn Phe Leu Lys  Asn Leu Phe Leu Thr  Lys Gln Asn 
    1235                 1240                 1245             


Val Thr  Val Glu Gly Leu Asp  Glu Gly Pro Tyr Thr  Pro Ile Leu 
    1250                 1255                 1260             


Gln Asp  Thr Arg Ser Leu Asn  Asp Ser Ala His Arg  Ala Gly Ile 
    1265                 1270                 1275             


His Met  Ala His Phe Ser Lys  Ile Arg Glu Glu Ala  Asn Leu Glu 
    1280                 1285                 1290             


Gly Leu  Gly Asn Gln Thr Lys  Gln Met Val Glu Arg  Phe Pro Ser 
    1295                 1300                 1305             


Thr Thr  Arg Met Ser Pro Asn  Pro Ser Gln His Asn  Val Ile Thr 
    1310                 1315                 1320             


Gln Arg  Gly Lys Arg Ala Leu  Lys Gln Pro Arg Leu  Ser Leu Glu 
    1325                 1330                 1335             


Glu Ile  Lys Phe Glu Arg Gly  Val Ile Leu Asn Asp  Thr Ser Thr 
    1340                 1345                 1350             


Gln Trp  Ser Lys Asn Met Asn  Tyr Leu Thr Gln Gly  Thr Leu Thr 
    1355                 1360                 1365             


Gln Ile  Glu Tyr Asn Glu Lys  Glu Lys Arg Ala Ile  Thr Gln Ser 
    1370                 1375                 1380             


Leu Leu  Ser Asp Cys Ser Met  Arg Asn His Gly Thr  Ile Gln Met 
    1385                 1390                 1395             


Asn Asp  Ser Ala Leu Pro Ile  Ala Lys Val Ser Ala  Phe Pro Ser 
    1400                 1405                 1410             


Ile Arg  His Thr Asp Leu Thr  Lys Ile Pro Ser Gln  Asp Asn Ser 
    1415                 1420                 1425             


Ser His  Leu Pro Ala Ser Ala  Cys Ser Tyr Thr Phe  Arg Glu Arg 
    1430                 1435                 1440             


Ser Ser  Gly Val Gln Glu Ser  Ser His Phe Leu Gln  Gly Ala Lys 
    1445                 1450                 1455             


Arg Asn  Asn Leu Ser Leu Ala  Phe Leu Thr Leu Glu  Met Ile Arg 
    1460                 1465                 1470             


Gly Gln  Gly Lys Phe Ser Ser  Leu Gly Lys Ser Ala  Thr Asn Gln 
    1475                 1480                 1485             


Pro Met  Tyr Lys Lys Leu Glu  Asn Thr Val Leu Leu  Lys Pro Gly 
    1490                 1495                 1500             


Leu Ser  Glu Ala Ser Gly Lys  Val Glu Leu Leu Pro  Lys Val His 
    1505                 1510                 1515             


Val His  Gln Glu Asp Ser Phe  Pro Thr Lys Thr Ser  Asn Asp Ser 
    1520                 1525                 1530             


Pro Gly  His Leu Asp Leu Met  Glu Lys Ile Phe Leu  Gln Lys Thr 
    1535                 1540                 1545             


Gln Gly  Pro Val Lys Leu Asn  Lys Val Asn Arg Pro  Gly Lys Val 
    1550                 1555                 1560             


Pro Phe  Leu Lys Trp Ala Thr  Glu Ser Ser Glu Lys  Ile Pro Ser 
    1565                 1570                 1575             


Lys Leu  Leu Gly Pro Leu Ala  Trp Asp Asn His Tyr  Ala Thr Gln 
    1580                 1585                 1590             


Ile Pro  Arg Glu Glu Trp Lys  Ser Gln Lys Lys Ser  Gln Lys Asn 
    1595                 1600                 1605             


Thr Ala  Phe Lys Thr Lys Asp  Thr Ile Leu Pro Leu  Gly Pro Cys 
    1610                 1615                 1620             


Glu Asn  Asn His Ser Ile Ala  Ala Ile Asn Glu Gly  Gln Asp Lys 
    1625                 1630                 1635             


Pro Gln  Arg Glu Ala Thr Trp  Ala Lys Gln Gly Glu  Thr Gly Arg 
    1640                 1645                 1650             


Leu Cys  Ser Gln Asn Pro Pro  Val Ser Lys Arg His  Gln Arg Glu 
    1655                 1660                 1665             


Ile Thr  Leu Thr Thr Leu Gln  Pro Glu Glu Asp Lys  Ile Glu Tyr 
    1670                 1675                 1680             


Asp Asp  Thr Phe Ser Ile Glu  Met Lys Arg Glu Asp  Phe Asp Ile 
    1685                 1690                 1695             


Tyr Gly  Glu Asp Glu Asn Gln  Gly Leu Arg Ser Phe  Gln Lys Arg 
    1700                 1705                 1710             


Thr Arg  His Tyr Phe Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr 
    1715                 1720                 1725             


Gly Met  Ser Arg Ser Pro His  Ala Leu Arg Asn Arg  Ala Gln Ser 
    1730                 1735                 1740             


Gly Asp  Val Pro Gln Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr 
    1745                 1750                 1755             


Asp Gly  Ser Phe Thr Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu 
    1760                 1765                 1770             


His Leu  Gly Leu Leu Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp 
    1775                 1780                 1785             


Asn Ile  Met Val Thr Phe Lys  Asn Gln Ala Ser Arg  Pro Tyr Ser 
    1790                 1795                 1800             


Phe Tyr  Ser Ser Leu Ile Ser  Tyr Glu Glu Asp Gln  Arg Gln Gly 
    1805                 1810                 1815             


Ala Glu  Pro Arg Lys Lys Phe  Val Asn Pro Asn Glu  Thr Lys Ile 
    1820                 1825                 1830             


Tyr Phe  Trp Lys Val Gln His  His Met Ala Pro Thr  Lys Asp Glu 
    1835                 1840                 1845             


Phe Asp  Cys Lys Ala Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Glu 
    1850                 1855                 1860             


Lys Asp  Val His Ser Gly Leu  Ile Gly Pro Leu Leu  Ile Cys Arg 
    1865                 1870                 1875             


Ser Asn  Thr Leu Asn Pro Ala  His Gly Arg Gln Val  Thr Val Gln 
    1880                 1885                 1890             


Glu Phe  Ala Leu Phe Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp 
    1895                 1900                 1905             


Tyr Phe  Thr Glu Asn Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn 
    1910                 1915                 1920             


Ile Gln  Lys Glu Asp Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His 
    1925                 1930                 1935             


Ala Ile  Asn Gly Tyr Val Met  Asp Thr Leu Pro Gly  Leu Val Met 
    1940                 1945                 1950             


Ala Gln  Asp Gln Lys Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser 
    1955                 1960                 1965             


Asn Glu  Asn Ile His Ser Ile  His Phe Ser Gly His  Val Phe Thr 
    1970                 1975                 1980             


Val Arg  Lys Lys Glu Glu Tyr  Lys Met Ala Val Tyr  Asn Leu Tyr 
    1985                 1990                 1995             


Pro Gly  Val Phe Glu Thr Val  Glu Met Leu Pro Ser  Lys Val Gly 
    2000                 2005                 2010             


Ile Trp  Arg Ile Glu Cys Leu  Ile Gly Glu His Leu  Gln Ala Gly 
    2015                 2020                 2025             


Met Ser  Thr Leu Phe Leu Val  Tyr Ser Lys Lys Cys  Gln Thr Pro 
    2030                 2035                 2040             


Leu Gly  Met Ala Ser Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala 
    2045                 2050                 2055             


Ser Gly  Gln Tyr Gly Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His 
    2060                 2065                 2070             


Tyr Ser  Gly Ser Ile Asn Ala  Trp Ser Thr Lys Asp  Pro Phe Ser 
    2075                 2080                 2085             


Trp Ile  Lys Val Asp Leu Leu  Ala Pro Met Ile Ile  His Ser Ile 
    2090                 2095                 2100             


Met Thr  Gln Gly Ala Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser 
    2105                 2110                 2115             


Gln Phe  Ile Ile Met Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Ser 
    2120                 2125                 2130             


Tyr Arg  Gly Asn Ser Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn 
    2135                 2140                 2145             


Val Asp  Ser Ser Gly Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile 
    2150                 2155                 2160             


Ile Ala  Arg Tyr Ile Arg Leu  His Pro Thr His Tyr  Ser Ile Arg 
    2165                 2170                 2175             


Ser Thr  Leu Arg Met Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys 
    2180                 2185                 2190             


Ser Met  Pro Leu Gly Met Glu  Asn Lys Ala Ile Ser  Asp Ala Gln 
    2195                 2200                 2205             


Ile Thr  Ala Ser Ser Tyr Leu  Asn Ser Met Phe Ala  Thr Trp Ser 
    2210                 2215                 2220             


Pro Ser  Gln Ala Arg Leu His  Leu Gln Gly Arg Thr  Asn Ala Trp 
    2225                 2230                 2235             


Arg Pro  Gln Ala Asn Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe 
    2240                 2245                 2250             


Gln Lys  Thr Met Lys Val Thr  Gly Ile Thr Thr Gln  Gly Val Lys 
    2255                 2260                 2265             


Ser Leu  Leu Thr Ser Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser 
    2270                 2275                 2280             


Ser Gln  Asp Gly His Asn Trp  Thr Leu Phe Leu Gln  Asn Gly Lys 
    2285                 2290                 2295             


Val Lys  Val Phe Gln Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val 
    2300                 2305                 2310             


Asn Ser  Leu Asp Pro Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His 
    2315                 2320                 2325             


Pro Gln  Ser Trp Ala His Gln  Ile Ala Leu Arg Leu  Glu Val Leu 
    2330                 2335                 2340             


Gly Cys  Glu Ala Gln Gln Leu  Tyr 
    2345                 2350     


<210>  37
<211>  2331
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  37

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Thr Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Glu Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Pro Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Arg Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Ile Pro Gly Glu Ser Tyr Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Asn Glu Ser Leu Thr Gln Ala Met 
225                 230                 235                 240 


Asp Pro Ala Ser Ala Arg Ala Gln Pro Glu Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Lys Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Ser Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Tyr Asp Ser Asp Met Asp Val Val Arg Phe Asp Gly Asp Asn 
    370                 375                 380                 


Ser Pro Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Pro Asn Asp Arg Ser Tyr Lys Ser Leu Tyr Leu 
            420                 425                 430         


Asn Asn Gly Pro Gln Gln Ile Gly Arg Lys Tyr Lys Lys Ala Arg Phe 
        435                 440                 445             


Met Ala Tyr Thr Asp Glu Thr Phe Lys Thr Arg Glu Ala Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Ser Pro Leu His Ser Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Met Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Leu Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Asp Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Val Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asn Arg Asn Thr Gly 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Pro Thr Ser Leu Leu Asn 
            740                 745                 750         


Glu Asn Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
        755                 760                 765             


Pro Ser Thr Arg Gln Lys Gln Phe Lys Ala Thr Thr Thr Pro Glu Asn 
    770                 775                 780                 


Asp Val Glu Lys Ile Asp Leu Arg Ser Gly Glu Arg Thr Gln Leu Leu 
785                 790                 795                 800 


Lys Val Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Asn Pro Thr Pro His Ala Leu Ser Leu Ser Asp Leu Gln Glu Val Thr 
            820                 825                 830         


Tyr Glu Ala Asp Asp His Leu Pro Gly Thr Ile Glu Arg Asn Lys Gly 
        835                 840                 845             


Pro Ser Glu Val Ala His Leu Arg Pro Glu Leu His His Ser Gly Asp 
    850                 855                 860                 


Arg Val Phe Thr Pro Glu Pro Glu Leu Gln Leu Arg Leu Asn Glu Asn 
865                 870                 875                 880 


Leu Gly Thr Thr Ile Thr Val Glu Leu Lys Lys Leu Asp Leu Lys Ile 
                885                 890                 895     


Ser Ser Ser Ser Asn Asn Leu Met Ile Ser Pro Thr Ile Pro Ser Asp 
            900                 905                 910         


Lys Leu Ala Ala Gly Thr Glu Lys Thr Gly Ser Leu Gly Pro Pro Asn 
        915                 920                 925             


Met Pro Val His Phe Ser Ser Gln Leu Gly Thr Ile Val Phe Gly Lys 
    930                 935                 940                 


Asn Ser Ser His Leu Ile Glu Ser Ala Val Pro Leu Gly Leu Ser Glu 
945                 950                 955                 960 


Gly Asp Asn Asp Ser Lys Leu Ile Glu Ala Ala Leu Met Asn Ser Gln 
                965                 970                 975     


Glu Ser Ser Leu Glu Glu Asn Val Leu Ser Met Glu Ser Asp Arg Leu 
            980                 985                 990         


Phe Lys Glu Glu Arg Val His Gly  Pro Val Ser Leu Thr  Lys Asp Asn 
        995                 1000                 1005             


Ala Leu  Phe Lys Val Asn Phe  Ser Leu Val Lys Thr  Asn Lys Ala 
    1010                 1015                 1020             


Pro Ile  Asn Ser Thr Thr Asn  Arg Lys Thr His Ile  Asp Gly Pro 
    1025                 1030                 1035             


Thr Leu  Leu Ile Glu Asn Ser  Thr Ser Val Trp Gln  Asp Ile Ile 
    1040                 1045                 1050             


Leu Glu  Ser Asn Ser Gly Phe  Gln Glu Val Thr Ser  Leu Ile His 
    1055                 1060                 1065             


Asp Glu  Thr Phe Met Asp Lys  Asn Thr Thr Ala Leu  Gly Leu Asn 
    1070                 1075                 1080             


His Val  Ser Asn Lys Thr Thr  Ser Ser Lys Asn Met  Glu Met Val 
    1085                 1090                 1095             


His Gln  Lys Lys Glu Asp Pro  Ala Pro Leu Gly Ala  Glu Asn Pro 
    1100                 1105                 1110             


Asp Ile  Ser Phe Phe Lys Met  Leu Phe Leu Pro Asp  Ser Ala Asn 
    1115                 1120                 1125             


Trp Ile  Lys Arg Thr His Cys  Lys Asn Ser Leu Ser  Ser Gly Gln 
    1130                 1135                 1140             


Arg Pro  Ser Pro Lys Gln Leu  Thr Ser Leu Gly Ser  Glu Lys Ser 
    1145                 1150                 1155             


Val Lys  Asp Gln Asn Phe Leu  Ser Glu Lys Asn Lys  Val Val Val 
    1160                 1165                 1170             


Gly Glu  Asp Glu Phe Thr Lys  Asp Thr Gly Leu Lys  Glu Met Ile 
    1175                 1180                 1185             


Phe Pro  Asn Ser Lys Ser Ile  Phe Leu Thr Asn Leu  Ala Asn Val 
    1190                 1195                 1200             


Gln Glu  Asn Asp Thr His Asn  Gln Glu Lys Asn Ser  Gln Glu Glu 
    1205                 1210                 1215             


Ile Glu  Arg Lys Glu Lys Leu  Ile Gln Lys Asn Val  Val Leu Pro 
    1220                 1225                 1230             


Gln Val  Tyr Thr Val Thr Gly  Thr Lys Asn Phe Leu  Lys Asn Leu 
    1235                 1240                 1245             


Phe Leu  Leu Ser Thr Lys Gln  Asn Val Glu Gly Leu  Asp Glu Gly 
    1250                 1255                 1260             


Thr Tyr  Thr Pro Ile Leu Gln  Asp Thr Arg Ser Leu  Asn Glu Ser 
    1265                 1270                 1275             


Ala Asn  Arg Ala Arg Ile His  Met Ala His Phe Ser  Lys Ile Arg 
    1280                 1285                 1290             


Glu Glu  Ala Asn Leu Glu Gly  Leu Gly Asn Gln Thr  Lys Gln Met 
    1295                 1300                 1305             


Val Glu  Lys Tyr Pro Ser Thr  Thr Arg Met Ser Pro  Asn Pro Arg 
    1310                 1315                 1320             


Gln Gln  Asn Val Ile Thr His  His Gly Lys Arg Ala  Leu Lys Gln 
    1325                 1330                 1335             


Phe Arg  Leu Pro Gln Glu Glu  Ile Lys Leu Glu Arg  Gly Val Ile 
    1340                 1345                 1350             


Leu Asn  Asp Thr Ser Thr Gln  Trp Ser Lys Asn Met  Lys Tyr Leu 
    1355                 1360                 1365             


Thr Gln  Gly Thr Leu Thr Gln  Ile Glu Tyr Asn Glu  Lys Glu Lys 
    1370                 1375                 1380             


Arg Ala  Ile Thr Gln Ser Leu  Leu Ser Asp Cys Ser  Val Arg Ser 
    1385                 1390                 1395             


His Gly  Ile Ile Gln Thr Asn  Gly Ser Ala Leu Pro  Ile Ala Lys 
    1400                 1405                 1410             


Val Ser  Ala Phe Pro Ser Ile  Arg Pro Thr Asp Leu  Thr Lys Ile 
    1415                 1420                 1425             


Pro Ser  Gln Asp Asn Ser Ser  His Leu Leu Ala Ser  Ala Cys Ser 
    1430                 1435                 1440             


Tyr Thr  Phe Arg Glu Lys Ser  Ser Gly Ile Gln Glu  Ser Ser His 
    1445                 1450                 1455             


Phe Leu  Gln Gly Ala Lys Arg  Asn Asn Leu Ser Leu  Ala Phe Leu 
    1460                 1465                 1470             


Thr Leu  Glu Met Ile Arg Gly  Gln Gly Lys Ile Ser  Ser Leu Gly 
    1475                 1480                 1485             


Lys Leu  Ser Glu Ala Ser Gly  Lys Val Glu Leu Leu  Pro Lys Val 
    1490                 1495                 1500             


His Val  His Gln Glu Asp Ser  Phe Pro Thr Lys Thr  Ser Asn Gly 
    1505                 1510                 1515             


Ser Pro  Gly His Leu Asp Leu  Met Glu Glu Ile Phe  Leu Gln Lys 
    1520                 1525                 1530             


Thr Gln  Gly Pro Val Lys Leu  Asn Lys Val Asn Arg  Pro Gly Lys 
    1535                 1540                 1545             


Ile Pro  Phe Leu Lys Trp Ala  Ala Glu Ser Ser Glu  Lys Thr Pro 
    1550                 1555                 1560             


Ser Lys  Leu Leu Gly Pro Leu  Ala Thr Gln Ile Pro  Arg Glu Glu 
    1565                 1570                 1575             


Trp Asn  Ser Gln Glu Lys Ser  Gln Lys Asn Lys Ala  Phe Lys Thr 
    1580                 1585                 1590             


Lys Asp  Thr Ile Ser Pro Leu  Asp Pro Cys Glu Asn  Asn His Ser 
    1595                 1600                 1605             


Ile Ala  Ala Ile Asn Lys Gly  Gln Asp Lys Pro Gln  Arg Glu Ala 
    1610                 1615                 1620             


Thr Trp  Ala Lys Gln Glu Glu  Thr Gly Arg Leu Cys  Ser Gln Asn 
    1625                 1630                 1635             


Pro Pro  Val Leu Lys Arg His  Gln Arg Gln Ile Thr  Leu Thr Thr 
    1640                 1645                 1650             


Val Gln  Pro Glu Glu Asp Lys  Ile Asp Tyr Asp Asp  Thr Phe Ser 
    1655                 1660                 1665             


Thr Glu  Thr Lys Arg Glu Asp  Phe Asp Ile Tyr Gly  Glu Asp Glu 
    1670                 1675                 1680             


Asn Gln  Asp Pro Arg Ser Phe  Gln Lys Arg Thr Arg  His Tyr Phe 
    1685                 1690                 1695             


Ile Ala  Ala Val Glu Arg Leu  Trp Asp Tyr Gly Met  Ser Arg Ser 
    1700                 1705                 1710             


Pro His  Ala Leu Arg Asn Arg  Ala Gln Ser Gly Asp  Val Pro Gln 
    1715                 1720                 1725             


Phe Lys  Lys Val Val Phe Gln  Glu Phe Thr Asp Gly  Ser Phe Thr 
    1730                 1735                 1740             


Gln Pro  Leu Tyr Arg Gly Glu  Leu Asn Glu His Leu  Gly Leu Leu 
    1745                 1750                 1755             


Gly Pro  Tyr Ile Arg Ala Glu  Val Glu Asp Asn Ile  Met Val Thr 
    1760                 1765                 1770             


Phe Lys  Asn Gln Ala Ser Arg  Pro Tyr Ser Phe Tyr  Ser Ser Leu 
    1775                 1780                 1785             


Ile Ser  Tyr Glu Asp Asp Gln  Arg Gln Gly Ala Glu  Pro Arg Lys 
    1790                 1795                 1800             


Lys Phe  Val Lys Pro Asn Glu  Thr Glu Val Tyr Phe  Trp Lys Val 
    1805                 1810                 1815             


Gln His  His Met Ala Pro Thr  Lys Asp Glu Phe Asp  Cys Lys Ala 
    1820                 1825                 1830             


Trp Ala  Tyr Phe Ser Asp Val  Asp Leu Asp Lys Asp  Val His Ser 
    1835                 1840                 1845             


Gly Leu  Val Gly Pro Leu Leu  Ile Cys Arg Ala Asn  Thr Leu Asn 
    1850                 1855                 1860             


Pro Ala  His Gly Arg Gln Val  Thr Val Gln Glu Phe  Ala Leu Phe 
    1865                 1870                 1875             


Phe Thr  Ile Phe Asp Glu Thr  Lys Ser Trp Tyr Phe  Thr Glu Asn 
    1880                 1885                 1890             


Met Glu  Arg Asn Cys Arg Ala  Pro Cys Asn Ile Gln  Met Glu Asp 
    1895                 1900                 1905             


Pro Thr  Phe Lys Glu Asn Tyr  Arg Phe His Ala Ile  Asn Gly Tyr 
    1910                 1915                 1920             


Val Met  Asp Thr Leu Pro Gly  Leu Val Met Ala Gln  Asp Gln Arg 
    1925                 1930                 1935             


Ile Arg  Trp Tyr Leu Leu Ser  Met Gly Ser Asn Glu  Asn Ile His 
    1940                 1945                 1950             


Ser Ile  His Phe Ser Gly His  Val Phe Thr Val Arg  Lys Lys Glu 
    1955                 1960                 1965             


Glu Tyr  Lys Met Ala Val Tyr  Asn Leu Tyr Pro Gly  Val Phe Glu 
    1970                 1975                 1980             


Thr Val  Glu Met Leu Pro Ser  Lys Val Gly Ile Trp  Arg Ile Glu 
    1985                 1990                 1995             


Cys Leu  Ile Gly Glu His Leu  Gln Ala Gly Met Ser  Thr Leu Phe 
    2000                 2005                 2010             


Leu Val  Tyr Ser Lys Lys Cys  Gln Thr Pro Leu Gly  Met Ala Ser 
    2015                 2020                 2025             


Gly His  Ile Arg Asp Phe Gln  Ile Thr Ala Ser Gly  Gln Tyr Gly 
    2030                 2035                 2040             


Gln Trp  Ala Pro Lys Leu Ala  Arg Leu His Tyr Ser  Gly Ser Ile 
    2045                 2050                 2055             


Asn Ala  Trp Ser Thr Lys Asp  Pro Phe Ser Trp Ile  Lys Val Asp 
    2060                 2065                 2070             


Leu Leu  Ala Pro Met Ile Ile  His Ser Ile Met Thr  Gln Gly Ala 
    2075                 2080                 2085             


Arg Gln  Lys Phe Ser Ser Leu  Tyr Ile Ser Gln Phe  Ile Ile Met 
    2090                 2095                 2100             


Tyr Ser  Leu Asp Gly Lys Lys  Trp Gln Ser Tyr Arg  Gly Asn Ser 
    2105                 2110                 2115             


Thr Gly  Thr Leu Met Val Phe  Phe Gly Asn Val Asp  Ser Ser Gly 
    2120                 2125                 2130             


Ile Lys  His Asn Ile Phe Asn  Pro Pro Ile Ile Ala  Arg Tyr Ile 
    2135                 2140                 2145             


Arg Leu  His Pro Thr His Tyr  Ser Ile Arg Ser Thr  Leu Arg Met 
    2150                 2155                 2160             


Glu Leu  Met Gly Cys Asp Leu  Asn Ser Cys Ser Met  Pro Leu Gly 
    2165                 2170                 2175             


Met Glu  Asn Lys Ala Ile Ala  Asp Ala Gln Ile Thr  Ala Ser Ser 
    2180                 2185                 2190             


Tyr Leu  Asn Asn Met Phe Ala  Thr Trp Ser Pro Ser  Gln Ala Arg 
    2195                 2200                 2205             


Leu His  Leu Gln Gly Arg Thr  Asn Ala Trp Arg Pro  Arg Val Asn 
    2210                 2215                 2220             


Asn Pro  Lys Glu Trp Leu Gln  Val Asp Phe Gln Lys  Thr Met Lys 
    2225                 2230                 2235             


Val Thr  Gly Ile Thr Thr Gln  Gly Val Lys Ser Leu  Leu Thr Ser 
    2240                 2245                 2250             


Met Tyr  Val Lys Glu Phe Leu  Ile Ser Ser Ser Gln  Asp Gly His 
    2255                 2260                 2265             


Asn Trp  Thr Leu Phe Leu Gln  Asn Gly Lys Val Lys  Val Phe Gln 
    2270                 2275                 2280             


Gly Asn  Gln Asp Ser Phe Thr  Pro Val Val Asn Ser  Leu Asp Pro 
    2285                 2290                 2295             


Pro Leu  Leu Thr Arg Tyr Leu  Arg Ile His Pro Gln  Ser Trp Gly 
    2300                 2305                 2310             


His Gln  Ile Ala Leu Arg Leu  Glu Val Leu Gly Cys  Glu Ala Gln 
    2315                 2320                 2325             


Gln Leu  Tyr 
    2330     


<210>  38
<211>  2358
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  38

Met Gln Ile Glu Leu Ser Val Cys Phe Phe Leu Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Leu Leu Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Phe Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Arg Ala Glu Val Tyr Asp Thr Val Ile Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Asp Asp Lys Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Ile Pro Gly Glu Ser His Thr Tyr Ile Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Glu Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Ala Asn Glu Ser Leu Ala Gln Gly Val 
225                 230                 235                 240 


Asp Ser Ala Ser Thr Arg Pro Trp Pro Lys Met Tyr Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Pro Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Lys Lys Asn Asn Glu Glu Glu Glu Asp Tyr Glu Asp 
        355                 360                 365             


Asp Leu Tyr Asp Ser Asp Met Asp Val Leu Arg Phe Asp Asp Asp Asn 
    370                 375                 380                 


Ser Pro Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Ile His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ala Val Leu Pro Ser Thr Asp Arg Ser Tyr Lys Ser Gln Tyr Leu 
            420                 425                 430         


Asn Asn Gly Thr Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Ile Ala Tyr Thr Asp Glu Thr Phe Gln Thr Arg Glu Ala Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asn Val Ser Pro Leu His Ser Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Leu Gln Ile Met Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Ala Ser Asn Met Met Tyr Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Asn Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Phe Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Arg Asn Thr Asp 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Pro Thr Tyr Leu Leu Asn 
            740                 745                 750         


Glu Asn Ser Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Ser Arg His 
        755                 760                 765             


Pro Ser Pro Arg Gln Lys Gln Phe Lys Ala Thr Thr Ala Pro Glu Asn 
    770                 775                 780                 


Asp Ile Glu Lys Met Asp Pro Arg Phe Gly Glu Arg Thr Gln Leu Leu 
785                 790                 795                 800 


Lys Ala Gln Ser Val Ser Ser Ser Asp Leu Leu Met Leu Leu Gly Gln 
                805                 810                 815     


Ser Pro Thr Pro His Gly Leu Ser Leu Ser Asp Leu Gln Glu Ala Lys 
            820                 825                 830         


Tyr Glu Ala Ile Pro Asp Asp Pro Ser Pro Gly Ala Ile Glu Asn Lys 
        835                 840                 845             


Glu Gly Pro Ser Glu Val Ala His Leu Arg Pro Glu Leu His His Ser 
    850                 855                 860                 


Glu Asp Met Val Phe Thr Pro Glu Pro Gly Leu Gln Leu Arg Leu Asn 
865                 870                 875                 880 


Glu Asn Leu Glu Thr Thr Ile Thr Glu Asp Leu Lys Lys Leu Asp Leu 
                885                 890                 895     


Lys Val Ser Ser Ser Ser Asn Asn Val Met Thr Ser Pro Ile Ser Ser 
            900                 905                 910         


Ser Asp Asn Leu Pro Ala Asp Thr Glu Lys Thr Asp Ser Leu Gly Pro 
        915                 920                 925             


Leu Asn Thr Pro Val His Phe Ser Ser Gln Leu Gly Thr Ile Leu Phe 
    930                 935                 940                 


Gly Lys Lys Ser Ser Pro Leu Ile Gly Ser Gly Val Pro Leu Asn Leu 
945                 950                 955                 960 


Ser Glu Arg Asp Asn Asp Ser Thr Leu Leu Glu Ala Ala Leu Met Ser 
                965                 970                 975     


Ser Gln Glu Ser Ser Leu Gly Lys Lys Val Ser Ser Met Glu Ser Asp 
            980                 985                 990         


Arg Leu Phe Lys Glu Lys Lys Val  His Gly Pro Ala Ser  Leu Thr Lys 
        995                 1000                 1005             


Asp Asn  Ala Leu Phe Lys Val  Asn Ile Ser Leu Val  Lys Thr Asn 
    1010                 1015                 1020             


Lys Thr  Pro Asn Asn Ser Thr  Thr Asn Arg Lys Thr  His Ile Asp 
    1025                 1030                 1035             


Gly Pro  Thr Leu Leu Asn Glu  Asn Ser Thr Ser Gly  Trp Gln Asp 
    1040                 1045                 1050             


Ile Leu  Lys Asn Asp Thr Glu  Phe Gln Glu Val Thr  Ser Leu Ile 
    1055                 1060                 1065             


His Asn  Glu Met Phe Met Asp  Lys Asn Thr Thr Ala  Leu Gly Leu 
    1070                 1075                 1080             


Asn His  Val Ser Asn Lys Thr  Thr Ser Ser Lys Asp  Met Glu Met 
    1085                 1090                 1095             


Val His  Gln Lys Lys Glu Asp  Pro Val Ser Leu Asp  Ala Glu Asn 
    1100                 1105                 1110             


Pro Asp  Met Ser Phe Phe Lys  Met Leu Phe Leu Pro  Asp Ser Ala 
    1115                 1120                 1125             


Asn Trp  Ile Lys Arg Thr His  Gly Lys Asn Ser Leu  Ser Ser Glu 
    1130                 1135                 1140             


Gln Gly  Pro Ser Pro Lys Gln  Leu Ile Ser Leu Gly  Ser Glu Asn 
    1145                 1150                 1155             


Ser Val  Lys Asp Gln Asn Phe  Leu Ser Glu Lys Asn  Lys Val Ala 
    1160                 1165                 1170             


Val Gly  Glu Asp Glu Phe Thr  Lys Asp Thr Gly Phe  Lys Glu Met 
    1175                 1180                 1185             


Ile Phe  Pro Asn Ser Lys Ser  Ile Phe Leu Thr Asn  Leu Ala Asn 
    1190                 1195                 1200             


Val Gln  Glu Asn Asp Thr Gln  Asn Gln Glu Lys Lys  Phe Gln Glu 
    1205                 1210                 1215             


Glu Ile  Glu Arg Lys Glu Thr  Leu Ile Gln Glu Asn  Val Gly Leu 
    1220                 1225                 1230             


Pro Gln  Val Phe Pro Val Thr  Gly Thr Lys Asn Phe  Leu Lys Thr 
    1235                 1240                 1245             


Leu Phe  Leu Leu Ser Thr Arg  Gln Asn Val Thr Val  Glu Gly Leu 
    1250                 1255                 1260             


Asp Glu  Gly Thr Tyr Ala Pro  Val Leu Gln Asp Thr  Arg Ser Leu 
    1265                 1270                 1275             


Asn Asp  Ser Ala Asn Arg Leu  Gly Leu His Met Ala  His Phe Ser 
    1280                 1285                 1290             


Lys Arg  Arg Glu Glu Ala Asn  Leu Glu Gly Leu Arg  Asn Gln Thr 
    1295                 1300                 1305             


Lys Gln  Met Val Glu Lys Tyr  Pro Ser Pro Thr Arg  Met Ser Pro 
    1310                 1315                 1320             


Asn Pro  Ser Gln Gln Asn Ala  Ile Thr Gln Arg Ser  Lys Arg Ala 
    1325                 1330                 1335             


Leu Lys  Gln Phe Gly Pro Pro  Leu Glu Glu Ile Glu  Leu Glu Arg 
    1340                 1345                 1350             


Gly Leu  Ile Val Asn Asp Thr  Ser Thr Leu Gln Ser  Arg Asn Met 
    1355                 1360                 1365             


Lys Tyr  Leu Thr Gln Gly Thr  Leu Thr Gln Ile Asp  Tyr Asn Glu 
    1370                 1375                 1380             


Lys Glu  Lys Arg Ala Ile Thr  Gln Ser Pro Leu Ser  Asp Cys Ser 
    1385                 1390                 1395             


Met Arg  Asn His Val Ile Thr  Gln Thr Asn Gly Ser  Ala Leu Pro 
    1400                 1405                 1410             


Ile Ala  Lys Thr Ser Ala Phe  Pro Ser Ile Arg Pro  Thr Asp Leu 
    1415                 1420                 1425             


Thr Lys  Ile Pro Ser Gln Asp  Asn Ser Ser His Leu  Leu Ser Ser 
    1430                 1435                 1440             


Ala Cys  Asn Tyr Thr Phe Arg  Glu Lys Ser Ser Gly  Val Gln Glu 
    1445                 1450                 1455             


Ser Ser  His Phe Leu Gln Gly  Ala Lys Arg Asn Asn  Leu Ser Ser 
    1460                 1465                 1470             


Ala Ile  Leu Thr Leu Asp Met  Ile Arg Gly Gln Glu  Lys Val Ile 
    1475                 1480                 1485             


Ser Leu  Ser Ala Thr Asp Pro  Leu Met Tyr Lys Lys  Leu Glu Asn 
    1490                 1495                 1500             


Thr Val  Leu Leu Lys Pro Gly  Leu Pro Glu Ala Ser  Gly Lys Val 
    1505                 1510                 1515             


Glu Leu  Leu Pro Lys Ile His  Val His Gln Glu Asp  Pro Phe Pro 
    1520                 1525                 1530             


Thr Glu  Thr Ser Asn Gly Ser  Pro Gly His Leu Asp  Leu Met Glu 
    1535                 1540                 1545             


Glu Ile  Leu Leu Gln Lys Thr  Gln Gly Ala Ile Lys  Leu Asn Lys 
    1550                 1555                 1560             


Val Asn  Arg Pro Gly Lys Val  Pro Phe Leu Lys Gly  Ala Thr Glu 
    1565                 1570                 1575             


Ser Ser  Glu Lys Thr Leu Pro  Lys Leu Leu Gly Pro  Leu Ala Trp 
    1580                 1585                 1590             


Asp Asn  Gln Tyr Ala Thr Gln  Ile Ser Arg Glu Glu  Trp Gln Ser 
    1595                 1600                 1605             


Gln Glu  Lys Ser Pro Lys Asn  Thr Ala Phe Asn Thr  Lys Asp Thr 
    1610                 1615                 1620             


Ile Ser  Pro Leu Asn Pro Cys  Glu Asn Asn His Ala  Ile Ala Ala 
    1625                 1630                 1635             


Ile Asn  Glu Gly Gln Asp Arg  Leu Gln Lys Glu Ala  Thr Trp Ala 
    1640                 1645                 1650             


Lys Gln  Gly Glu Thr Glu Arg  Leu Cys Ser Glu Asn  Pro Pro Val 
    1655                 1660                 1665             


Leu Lys  His His Pro Arg Glu  Ile Thr Leu Thr Ala  Leu Gln Gln 
    1670                 1675                 1680             


Glu Gln  Glu Lys Ile Asp Tyr  Asp Asp Ala Leu Ser  Ile Glu Thr 
    1685                 1690                 1695             


Lys Arg  Glu Asp Phe Asp Ile  Tyr Gly Glu Asp Glu  Asn Gln Gly 
    1700                 1705                 1710             


Pro Arg  Ser Phe Gln Lys Lys  Thr Arg His Tyr Phe  Ile Ala Ala 
    1715                 1720                 1725             


Val Glu  Arg Leu Trp Asp Tyr  Gly Met Ser Lys Ser  Pro His Ala 
    1730                 1735                 1740             


Leu Arg  Asn Arg Ala Gln Ser  Gly Ser Val Pro Gln  Phe Lys Lys 
    1745                 1750                 1755             


Val Val  Phe Gln Glu Phe Thr  Asp Gly Ser Phe Thr  Gln Pro Leu 
    1760                 1765                 1770             


Tyr Arg  Gly Glu Leu Asn Glu  His Leu Gly Leu Leu  Gly Pro Tyr 
    1775                 1780                 1785             


Ile Arg  Ala Glu Val Glu Asp  Asn Ile Met Val Thr  Phe Lys Asn 
    1790                 1795                 1800             


Gln Ala  Ser Arg Pro Tyr Ser  Phe Tyr Ser Ser Leu  Ile Ser Tyr 
    1805                 1810                 1815             


Glu Glu  Asp Gln Arg Gln Gly  Thr Glu Pro Arg Lys  Asn Leu Val 
    1820                 1825                 1830             


Lys Pro  Asn Glu Thr Lys Thr  Tyr Phe Trp Lys Val  Gln His His 
    1835                 1840                 1845             


Met Ala  Pro Thr Lys Asp Glu  Phe Asp Cys Lys Ala  Trp Ala Tyr 
    1850                 1855                 1860             


Phe Ser  Asp Val Asp Leu Glu  Lys Asp Leu His Ser  Gly Leu Ile 
    1865                 1870                 1875             


Gly Pro  Leu Leu Ile Cys Arg  Thr Asn Thr Leu Asn  Pro Ala His 
    1880                 1885                 1890             


Gly Arg  Gln Leu Thr Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile 
    1895                 1900                 1905             


Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg 
    1910                 1915                 1920             


Asn Cys  Lys Ala Pro Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe 
    1925                 1930                 1935             


Lys Lys  Asn Tyr Arg Phe His  Ala Ile Asn Gly Tyr  Val Met Asp 
    1940                 1945                 1950             


Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp 
    1955                 1960                 1965             


Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn Ile His  Ser Ile His 
    1970                 1975                 1980             


Phe Ser  Gly His Val Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys 
    1985                 1990                 1995             


Met Ala  Val Tyr Asn Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu 
    2000                 2005                 2010             


Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile 
    2015                 2020                 2025             


Gly Glu  His Leu Gln Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr 
    2030                 2035                 2040             


Ser Lys  Glu Cys Gln Thr Pro  Leu Gly Met Ala Ser  Gly Arg Ile 
    2045                 2050                 2055             


Arg Asp  Ser Gln Ile Thr Ala  Ser Gly His Tyr Gly  Gln Trp Ala 
    2060                 2065                 2070             


Pro Lys  Leu Ala Arg Leu His  Tyr Thr Gly Ser Ile  Asn Ala Trp 
    2075                 2080                 2085             


Ser Thr  Lys Asp Pro Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala 
    2090                 2095                 2100             


Pro Met  Ile Ile His Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys 
    2105                 2110                 2115             


Leu Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu 
    2120                 2125                 2130             


Asp Gly  Lys Lys Trp Gln Ser  Tyr Arg Gly Asn Ser  Thr Gly Thr 
    2135                 2140                 2145             


Leu Met  Val Phe Phe Gly Asn  Val Asp Ser Ser Gly  Ile Lys His 
    2150                 2155                 2160             


Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Gln Tyr Ile  Arg Leu His 
    2165                 2170                 2175             


Pro Thr  His His Ser Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met 
    2180                 2185                 2190             


Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser 
    2195                 2200                 2205             


Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr 
    2210                 2215                 2220             


Asn Met  Phe Ala Thr Trp Ser  Pro Ser Gln Ala Arg  Leu His Leu 
    2225                 2230                 2235             


Gln Gly  Arg Thr Asn Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys 
    2240                 2245                 2250             


Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly 
    2255                 2260                 2265             


Ile Thr  Thr Gln Gly Ala Lys  Ser Leu Leu Thr Ser  Met Tyr Val 
    2270                 2275                 2280             


Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp Gly His  His Trp Thr 
    2285                 2290                 2295             


Leu Phe  Leu Gln Asn Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln 
    2300                 2305                 2310             


Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu 
    2315                 2320                 2325             


Thr Arg  Tyr Leu Arg Ile Tyr  Pro Gln Ser Trp Val  His Gln Ile 
    2330                 2335                 2340             


Ala Leu  Arg Leu Glu Val Leu  Gly Cys Gln Ser Gln  Gln His Tyr 
    2345                 2350                 2355             


<210>  39
<211>  1453
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  39

Met Gln Ile Ala Leu Phe Thr Cys Phe Phe Leu Ser Leu Phe Asn Phe 
1               5                   10                  15      


Cys Ser Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asn Tyr Met Gln Ser Asp Leu Leu Ser Val Leu His Thr Asp Thr 
        35                  40                  45              


Arg Phe Leu Pro Arg Met Pro Thr Ser Phe Pro Phe Asn Thr Ser Ile 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Tyr Met Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Thr Glu Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Lys Glu Gly Ser Leu Ser Lys Glu Arg 
        195                 200                 205             


Thr Gln Met Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Asp Ser Phe Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Thr Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Ile Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Lys 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Trp Gln Lys Lys Asn Asn Glu Glu Met Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Asp Ser Glu Met Asp Met Phe Thr Leu Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys Tyr Pro Lys Thr Trp 
385                 390                 395                 400 


Ile His Tyr Ile Ser Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Ser 
                405                 410                 415     


Val Leu Thr Ser Asp Asp Gly Ser Tyr Lys Ser Gln Tyr Leu Ser Asn 
            420                 425                 430         


Gly Pro His Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Ile Ala 
        435                 440                 445             


Tyr Thr Asp Val Thr Phe Lys Thr Arg Glu Thr Ile Gln His Glu Ser 
    450                 455                 460                 


Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu 
465                 470                 475                 480 


Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His 
                485                 490                 495     


Gly Ile Thr Asp Val Ser Pro Leu His Ser Arg Arg Leu Pro Arg Gly 
            500                 505                 510         


Ile Lys His Val Lys Asp Leu Pro Ile Arg Pro Gly Glu Ile Phe Lys 
        515                 520                 525             


Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro 
    530                 535                 540                 


Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Pro Glu Arg Asp 
545                 550                 555                 560 


Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser 
                565                 570                 575     


Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn Val Ile 
            580                 585                 590         


Leu Phe Ser Val Phe Asp Glu Asn Gln Ser Trp Tyr Ile Thr Glu Asn 
        595                 600                 605             


Met Gln Arg Phe Leu Pro Asn Ala Ala Asp Thr Gln Pro Gln Asp Pro 
    610                 615                 620                 


Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe 
625                 630                 635                 640 


Asp Ser Leu Gln Leu Thr Val Cys Leu His Glu Val Ala Tyr Trp Tyr 
                645                 650                 655     


Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Ile Phe Phe Ser 
            660                 665                 670         


Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu 
        675                 680                 685             


Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly 
    690                 695                 700                 


Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Lys Arg Gly Met 
705                 710                 715                 720 


Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Ser Thr Ser Asp Tyr 
                725                 730                 735     


Tyr Glu Glu Ile Tyr Glu Asp Ile Pro Thr Gln Leu Val Asn Asp Asn 
            740                 745                 750         


Asn Val Ile Glu Pro Arg Ser Phe Phe Gln Asn Pro Pro Val Leu Lys 
        755                 760                 765             


Arg His Gln Arg Glu Leu Ser Ala Leu Gln Ser Glu Gln Glu Ala Thr 
    770                 775                 780                 


Asp Tyr Asp Asp Ser Ile Thr Ile Glu Thr Asn Glu Asp Phe Asp Ile 
785                 790                 795                 800 


Tyr Gly Glu Asp Ile Lys Gln Gly Pro Arg Ser Phe Gln Gln Lys Thr 
                805                 810                 815     


Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu Trp Asp Tyr Gly Met 
            820                 825                 830         


Ser Thr Ser Pro His Val Leu Arg Asn Arg Asp Gln Ser Gly Asn Ala 
        835                 840                 845             


Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe Thr Asp Gly Ser Phe 
    850                 855                 860                 


Ser Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu His Leu Gly Leu Leu 
865                 870                 875                 880 


Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn Ile Met Val Thr Phe 
                885                 890                 895     


Lys Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser 
            900                 905                 910         


Tyr Lys Glu Asp Gln Arg Gln Gly Glu Glu Pro Arg Arg Asn Phe Val 
        915                 920                 925             


Lys Pro Asn Glu Thr Lys Ile Tyr Phe Trp Lys Val Gln His His Met 
    930                 935                 940                 


Ala Pro Thr Glu Asp Glu Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser 
945                 950                 955                 960 


Asp Val Asp Leu Glu Arg Asp Met His Ser Gly Leu Ile Gly Pro Leu 
                965                 970                 975     


Leu Ile Cys His Thr Asn Thr Leu Asn Pro Ala His Gly Arg Gln Val 
            980                 985                 990         


Ala Val Gln Glu Phe Ala Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys 
        995                 1000                 1005             


Ser Trp  Tyr Phe Thr Glu Asn  Val Glu Arg Asn Cys  Lys Thr Pro 
    1010                 1015                 1020             


Cys Asn  Ile Gln Met Glu Asp  Pro Thr Leu Lys Glu  Asn Tyr Arg 
    1025                 1030                 1035             


Phe His  Ala Ile Asn Gly Tyr  Val Met Asp Thr Leu  Pro Gly Leu 
    1040                 1045                 1050             


Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met 
    1055                 1060                 1065             


Gly Ser  Asn Glu Asn Ile Gln  Ser Ile His Phe Ser  Gly His Val 
    1070                 1075                 1080             


Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys Met Ala  Val Tyr Asn 
    1085                 1090                 1095             


Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu Met Leu  Pro Ser Arg 
    1100                 1105                 1110             


Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile Gly Glu  His Leu Gln 
    1115                 1120                 1125             


Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr Ser Lys  Gln Cys Gln 
    1130                 1135                 1140             


Ile Pro  Leu Gly Met Ala Ser  Gly Ser Ile Arg Asp  Phe Gln Ile 
    1145                 1150                 1155             


Thr Ala  Ser Gly His Tyr Gly  Gln Trp Ala Pro Asn  Leu Ala Arg 
    1160                 1165                 1170             


Leu His  His Ser Gly Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro 
    1175                 1180                 1185             


Phe Ser  Trp Ile Lys Val Asp  Leu Leu Thr Pro Met  Ile Ile His 
    1190                 1195                 1200             


Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr 
    1205                 1210                 1215             


Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp 
    1220                 1225                 1230             


Leu Ser  Tyr Arg Gly Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe 
    1235                 1240                 1245             


Gly Asn  Val Asp Ser Ser Gly  Ile Lys His Asn Ser  Phe Asn Pro 
    1250                 1255                 1260             


Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His Pro Thr  His Ser Ser 
    1265                 1270                 1275             


Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn 
    1280                 1285                 1290             


Ser Cys  Ser Ile Pro Leu Gly  Met Glu Asn Lys Val  Ile Ser Asp 
    1295                 1300                 1305             


Thr Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr 
    1310                 1315                 1320             


Trp Ser  Pro Ser Gln Ala Arg  Leu His Leu Gln Gly  Arg Thr Asn 
    1325                 1330                 1335             


Ala Trp  Arg Pro Gln Val Asn  Asp Pro Lys Glu Trp  Leu Gln Val 
    1340                 1345                 1350             


Asp Leu  Gln Lys Thr Met Lys  Val Thr Gly Ile Ile  Thr Gln Gly 
    1355                 1360                 1365             


Val Lys  Ser Leu Phe Thr Ser  Met Phe Val Lys Glu  Phe Leu Ile 
    1370                 1375                 1380             


Ser Ser  Ser Gln Asp Gly His  His Trp Thr His Ile  Leu His Asn 
    1385                 1390                 1395             


Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln Asp Ser  Ser Thr Pro 
    1400                 1405                 1410             


Met Val  Asn Ser Leu Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg 
    1415                 1420                 1425             


Ile His  Pro Gln Ile Trp Glu  His Gln Ile Ala Leu  Arg Leu Glu 
    1430                 1435                 1440             


Ile Leu  Gly Cys Glu Ala Gln  Gln Leu Tyr 
    1445                 1450             


<210>  40
<211>  1458
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  40

Met Gln Ile Glu Leu Ser Thr Cys Phe Phe Leu Cys Leu Leu Gln Phe 
1               5                   10                  15      


Ser Phe Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asp Tyr Met Gln Ser Asp Leu Leu Ser Glu Leu His Val Asp Thr 
        35                  40                  45              


Arg Phe Pro Pro Arg Val Pro Arg Ser Phe Pro Phe Asn Thr Ser Val 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Phe Thr Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Arg Ala Glu Val Tyr Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Asp Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Arg Glu Gly Ser Leu Ala Lys Glu Arg 
        195                 200                 205             


Thr Gln Thr Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Asp Ser Leu Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Ala Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Met Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Gln 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Leu Arg Met Lys Asn Asn Glu Glu Glu Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Tyr Asp Ser Glu Met Asp Val Val Arg Phe Asp Asp Asp Asn 
    370                 375                 380                 


Ser Pro Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys 
385                 390                 395                 400 


Thr Trp Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala 
                405                 410                 415     


Pro Ser Val Leu Thr Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu 
            420                 425                 430         


Asn Asn Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe 
        435                 440                 445             


Met Ala Tyr Thr Asp Val Thr Phe Lys Thr Arg Glu Ala Ile Gln Tyr 
    450                 455                 460                 


Glu Ser Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr 
465                 470                 475                 480 


Leu Leu Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr 
                485                 490                 495     


Pro His Gly Ile Thr Asp Val Ser Pro Leu His Ser Gly Arg Leu Pro 
            500                 505                 510         


Lys Gly Val Lys His Leu Lys Asp Leu Pro Ile Leu Pro Gly Glu Ile 
        515                 520                 525             


Phe Lys Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser 
    530                 535                 540                 


Asp Pro Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Ile Asn Leu Glu 
545                 550                 555                 560 


Arg Asp Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys 
                565                 570                 575     


Glu Ser Val Asp Gln Arg Gly Asn Gln Met Met Ser Asp Lys Arg Asn 
            580                 585                 590         


Val Ile Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr 
        595                 600                 605             


Glu Asn Met Gln Arg Phe Leu Pro Asn Ala Ala Gly Val Gln Pro Gln 
    610                 615                 620                 


Asp Pro Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr 
625                 630                 635                 640 


Val Phe Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr 
                645                 650                 655     


Trp Tyr Ile Leu Ser Val Gly Ala Gln Thr Asp Phe Leu Ser Val Phe 
            660                 665                 670         


Phe Ser Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu 
        675                 680                 685             


Thr Leu Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn 
    690                 695                 700                 


Pro Gly Leu Trp Val Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg 
705                 710                 715                 720 


Gly Met Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Arg Asn Thr Gly 
                725                 730                 735     


Asp Tyr Tyr Glu Asp Thr Tyr Glu Asp Ile Pro Thr Tyr Leu Leu Ser 
            740                 745                 750         


Glu Asn Asn Val Ile Glu Pro Arg Ser Phe Ser Gln Asn Pro Pro Val 
        755                 760                 765             


Leu Lys Arg His Gln Arg Glu Ile Thr Leu Thr Thr Leu Gln Ser Glu 
    770                 775                 780                 


Gln Glu Glu Ile Asp Tyr Asp Asp Thr Ile Ser Ile Glu Thr Lys Arg 
785                 790                 795                 800 


Glu Asp Phe Asp Ile Tyr Gly Glu Asp Glu Asn Gln Gly Pro Arg Ser 
                805                 810                 815     


Phe Gln Lys Arg Thr Arg His Tyr Phe Ile Ala Ala Val Glu Arg Leu 
            820                 825                 830         


Trp Asp Tyr Gly Met Ser Arg Ser Pro His Val Leu Arg Asn Arg Ala 
        835                 840                 845             


Gln Ser Gly Ser Val Pro Gln Phe Lys Lys Val Val Phe Gln Glu Phe 
    850                 855                 860                 


Thr Asp Gly Ser Phe Thr Gln Pro Leu Tyr Arg Gly Glu Leu Asn Glu 
865                 870                 875                 880 


His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala Glu Val Glu Asp Asn 
                885                 890                 895     


Ile Met Val Thr Phe Lys Asn Gln Ala Ser Arg Pro Tyr Ser Phe Tyr 
            900                 905                 910         


Ser Ser Leu Ile Ser Tyr Glu Glu Asp Gln Arg Gln Gly Ala Glu Pro 
        915                 920                 925             


Arg Lys Asn Phe Val Lys Pro Asn Glu Thr Lys Thr Tyr Phe Trp Lys 
    930                 935                 940                 


Val Gln His His Met Ala Pro Thr Lys Asp Glu Phe Asp Cys Lys Ala 
945                 950                 955                 960 


Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Lys Asp Met His Ser Gly 
                965                 970                 975     


Leu Ile Gly Pro Leu Leu Ile Cys His Thr Asn Thr Leu Asn Pro Ala 
            980                 985                 990         


His Gly Arg Gln Val Thr Val Gln  Glu Phe Ala Leu Phe  Phe Thr Ile 
        995                 1000                 1005             


Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr Glu Asn  Met Glu Arg 
    1010                 1015                 1020             


Asn Cys  Arg Ala Pro Cys Asn  Ile Gln Met Glu Asp  Pro Thr Phe 
    1025                 1030                 1035             


Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn Gly Tyr  Val Met Asp 
    1040                 1045                 1050             


Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp Gln Arg  Ile Arg Trp 
    1055                 1060                 1065             


Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn Ile His  Ser Ile His 
    1070                 1075                 1080             


Phe Ser  Gly His Val Phe Thr  Val Arg Lys Lys Glu  Glu Tyr Lys 
    1085                 1090                 1095             


Met Ala  Val Tyr Asn Leu Tyr  Pro Gly Val Phe Glu  Thr Val Glu 
    1100                 1105                 1110             


Met Leu  Pro Ser Lys Ala Gly  Ile Trp Arg Val Glu  Cys Leu Ile 
    1115                 1120                 1125             


Gly Glu  His Leu His Ala Gly  Met Ser Thr Leu Phe  Leu Val Tyr 
    1130                 1135                 1140             


Ser Lys  Gln Cys Gln Thr Pro  Leu Gly Met Ala Ser  Gly His Ile 
    1145                 1150                 1155             


Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln Tyr Gly  Gln Trp Ala 
    1160                 1165                 1170             


Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly Ser Ile  Asn Ala Trp 
    1175                 1180                 1185             


Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys Val Asp  Leu Leu Ala 
    1190                 1195                 1200             


Pro Met  Ile Ile His Gly Ile  Lys Thr Gln Gly Ala  Arg Gln Lys 
    1205                 1210                 1215             


Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile Ile Met  Tyr Ser Leu 
    1220                 1225                 1230             


Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly Asn Ser  Thr Gly Thr 
    1235                 1240                 1245             


Leu Met  Val Phe Phe Gly Asn  Val Asp Ser Ser Gly  Ile Lys His 
    1250                 1255                 1260             


Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg Tyr Ile  Arg Leu His 
    1265                 1270                 1275             


Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu Arg Met  Glu Leu Met 
    1280                 1285                 1290             


Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro Leu Gly  Met Glu Ser 
    1295                 1300                 1305             


Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala Ser Ser  Tyr Phe Thr 
    1310                 1315                 1320             


Asn Met  Phe Ala Thr Trp Ser  Pro Ser Gln Ala Arg  Leu His Leu 
    1325                 1330                 1335             


Gln Gly  Arg Thr Asn Ala Trp  Arg Pro Gln Val Asn  Asn Pro Lys 
    1340                 1345                 1350             


Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr Met Lys  Val Thr Gly 
    1355                 1360                 1365             


Ile Thr  Thr Gln Gly Val Lys  Ser Leu Leu Thr Ser  Met Tyr Val 
    1370                 1375                 1380             


Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp Gly His  His Trp Thr 
    1385                 1390                 1395             


Leu Phe  Leu Gln Asn Gly Lys  Val Lys Val Phe Gln  Gly Asn Gln 
    1400                 1405                 1410             


Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu Asp Pro  Pro Leu Leu 
    1415                 1420                 1425             


Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser Trp Val  His Gln Ile 
    1430                 1435                 1440             


Ala Leu  Arg Leu Glu Val Leu  Gly Cys Glu Ala Gln  Gln Leu Tyr 
    1445                 1450                 1455             


<210>  41
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  41

Ser Arg Pro Pro Ser Ala Ser Ala Pro Lys 
1               5                   10  


<210>  42
<211>  1463
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  42

Met Gln Ile Ala Leu Phe Thr Cys Phe Phe Leu Ser Leu Phe Asn Phe 
1               5                   10                  15      


Cys Ser Ser Ala Thr Arg Arg Tyr Tyr Leu Gly Ala Val Glu Leu Ser 
            20                  25                  30          


Trp Asn Tyr Met Gln Ser Asp Leu Leu Ser Val Leu His Thr Asp Thr 
        35                  40                  45              


Arg Phe Leu Pro Arg Met Pro Thr Ser Phe Pro Phe Asn Thr Ser Ile 
    50                  55                  60                  


Met Tyr Lys Lys Thr Val Phe Val Glu Tyr Met Asp His Leu Phe Asn 
65                  70                  75                  80  


Ile Ala Lys Pro Arg Pro Pro Trp Met Gly Leu Leu Gly Pro Thr Ile 
                85                  90                  95      


Trp Thr Glu Val His Asp Thr Val Val Ile Thr Leu Lys Asn Met Ala 
            100                 105                 110         


Ser His Pro Val Ser Leu His Ala Val Gly Val Ser Tyr Trp Lys Ala 
        115                 120                 125             


Ser Glu Gly Ala Glu Tyr Glu Asp Gln Thr Ser Gln Arg Glu Lys Glu 
    130                 135                 140                 


Asp Asp Lys Val Phe Pro Gly Glu Ser His Thr Tyr Val Trp Gln Val 
145                 150                 155                 160 


Leu Lys Glu Asn Gly Pro Met Ala Ser Asp Pro Pro Cys Leu Thr Tyr 
                165                 170                 175     


Ser Tyr Leu Ser His Val Asp Leu Val Lys Asp Leu Asn Ser Gly Leu 
            180                 185                 190         


Ile Gly Ala Leu Leu Val Cys Lys Glu Gly Ser Leu Ser Lys Glu Arg 
        195                 200                 205             


Thr Gln Met Leu His Gln Phe Val Leu Leu Phe Ala Val Phe Asp Glu 
    210                 215                 220                 


Gly Lys Ser Trp His Ser Glu Thr Lys Asp Ser Phe Thr Gln Ala Met 
225                 230                 235                 240 


Asp Ser Ala Ser Thr Arg Ala Trp Pro Lys Met His Thr Val Asn Gly 
                245                 250                 255     


Tyr Val Asn Arg Ser Leu Pro Gly Leu Ile Gly Cys His Arg Lys Ser 
            260                 265                 270         


Val Tyr Trp His Val Ile Gly Met Gly Thr Thr Pro Glu Val His Ser 
        275                 280                 285             


Ile Phe Leu Glu Gly His Thr Phe Leu Val Arg Asn His Arg Gln Ala 
    290                 295                 300                 


Ser Leu Glu Ile Ser Pro Ile Thr Phe Leu Thr Ala Gln Thr Leu Leu 
305                 310                 315                 320 


Ile Asp Leu Gly Gln Phe Leu Leu Phe Cys His Ile Ser Ser His Lys 
                325                 330                 335     


His Asp Gly Met Glu Ala Tyr Val Lys Val Asp Ser Cys Pro Glu Glu 
            340                 345                 350         


Pro Gln Trp Gln Lys Lys Asn Asn Glu Glu Met Glu Asp Tyr Asp Asp 
        355                 360                 365             


Asp Leu Asp Ser Glu Met Asp Met Phe Thr Leu Asp Asp Asp Asn Ser 
    370                 375                 380                 


Pro Phe Ile Gln Ile Arg Ser Val Ala Lys Lys His Pro Lys Thr Trp 
385                 390                 395                 400 


Val His Tyr Ile Ala Ala Glu Glu Glu Asp Trp Asp Tyr Ala Pro Leu 
                405                 410                 415     


Val Leu Ala Pro Asp Asp Arg Ser Tyr Lys Ser Gln Tyr Leu Asn Asn 
            420                 425                 430         


Gly Pro Gln Arg Ile Gly Arg Lys Tyr Lys Lys Val Arg Phe Met Ala 
        435                 440                 445             


Tyr Thr Asp Val Thr Phe Lys Thr Arg Glu Ala Ile Gln His Glu Ser 
    450                 455                 460                 


Gly Ile Leu Gly Pro Leu Leu Tyr Gly Glu Val Gly Asp Thr Leu Leu 
465                 470                 475                 480 


Ile Ile Phe Lys Asn Gln Ala Ser Arg Pro Tyr Asn Ile Tyr Pro His 
                485                 490                 495     


Gly Ile Thr Asp Val Arg Pro Leu Tyr Ser Arg Arg Leu Pro Lys Gly 
            500                 505                 510         


Val Lys His Leu Lys Asp Phe Pro Ile Leu Pro Gly Glu Ile Phe Lys 
        515                 520                 525             


Tyr Lys Trp Thr Val Thr Val Glu Asp Gly Pro Thr Lys Ser Asp Pro 
    530                 535                 540                 


Arg Cys Leu Thr Arg Tyr Tyr Ser Ser Phe Val Asn Met Glu Arg Asp 
545                 550                 555                 560 


Leu Ala Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys Tyr Lys Glu Ser 
                565                 570                 575     


Val Asp Gln Arg Gly Asn Gln Ile Met Ser Asp Lys Arg Asn Val Ile 
            580                 585                 590         


Leu Phe Ser Val Phe Asp Glu Asn Arg Ser Trp Tyr Leu Thr Glu Asn 
        595                 600                 605             


Ile Gln Arg Phe Leu Pro Asn Pro Ala Gly Val Gln Leu Glu Asp Pro 
    610                 615                 620                 


Glu Phe Gln Ala Ser Asn Ile Met His Ser Ile Asn Gly Tyr Val Phe 
625                 630                 635                 640 


Asp Ser Leu Gln Leu Ser Val Cys Leu His Glu Val Ala Tyr Trp Tyr 
                645                 650                 655     


Ile Leu Ser Ile Gly Ala Gln Thr Asp Phe Leu Ser Val Phe Phe Ser 
            660                 665                 670         


Gly Tyr Thr Phe Lys His Lys Met Val Tyr Glu Asp Thr Leu Thr Leu 
        675                 680                 685             


Phe Pro Phe Ser Gly Glu Thr Val Phe Met Ser Met Glu Asn Pro Gly 
    690                 695                 700                 


Leu Trp Ile Leu Gly Cys His Asn Ser Asp Phe Arg Asn Arg Gly Met 
705                 710                 715                 720 


Thr Ala Leu Leu Lys Val Ser Ser Cys Asp Lys Asn Thr Gly Asp Tyr 
                725                 730                 735     


Tyr Glu Asp Ser Tyr Glu Asp Ile Ser Ala Tyr Leu Leu Ser Lys Asn 
            740                 745                 750         


Asn Ala Ile Glu Pro Arg Ser Phe Ala Gln Asn Ser Arg Pro Pro Ser 
        755                 760                 765             


Ala Ser Ala Pro Lys Pro Pro Val Leu Lys Arg His Gln Arg Glu Leu 
    770                 775                 780                 


Ser Ala Leu Gln Ser Glu Gln Glu Ala Thr Asp Tyr Asp Asp Ser Ile 
785                 790                 795                 800 


Thr Ile Glu Thr Asn Glu Asp Phe Asp Ile Tyr Gly Glu Asp Ile Lys 
                805                 810                 815     


Gln Gly Pro Arg Ser Phe Gln Gln Lys Thr Arg His Tyr Phe Ile Ala 
            820                 825                 830         


Ala Val Glu Arg Leu Trp Asp Tyr Gly Met Ser Thr Ser Pro His Val 
        835                 840                 845             


Leu Arg Asn Arg Asp Gln Ser Gly Asn Ala Pro Gln Phe Lys Lys Val 
    850                 855                 860                 


Val Phe Gln Glu Phe Thr Asp Gly Ser Phe Ser Gln Pro Leu Tyr Arg 
865                 870                 875                 880 


Gly Glu Leu Asn Glu His Leu Gly Leu Leu Gly Pro Tyr Ile Arg Ala 
                885                 890                 895     


Glu Val Glu Asp Asn Ile Met Val Thr Phe Lys Asn Gln Ala Ser Arg 
            900                 905                 910         


Pro Tyr Ser Phe Tyr Ser Ser Leu Ile Ser Tyr Lys Glu Asp Gln Arg 
        915                 920                 925             


Gln Gly Glu Glu Pro Arg Arg Asn Phe Val Lys Pro Asn Glu Thr Lys 
    930                 935                 940                 


Ile Tyr Phe Trp Lys Val Gln His His Met Ala Pro Thr Glu Asp Glu 
945                 950                 955                 960 


Phe Asp Cys Lys Ala Trp Ala Tyr Phe Ser Asp Val Asp Leu Glu Arg 
                965                 970                 975     


Asp Met His Ser Gly Leu Ile Gly Pro Leu Leu Ile Cys His Thr Asn 
            980                 985                 990         


Thr Leu Asn Pro Ala His Gly Arg  Gln Val Ala Val Gln  Glu Phe Ala 
        995                 1000                 1005             


Leu Phe  Phe Thr Ile Phe Asp  Glu Thr Lys Ser Trp  Tyr Phe Thr 
    1010                 1015                 1020             


Glu Asn  Val Glu Arg Asn Cys  Lys Thr Pro Cys Asn  Ile Gln Met 
    1025                 1030                 1035             


Glu Asp  Pro Thr Leu Lys Glu  Asn Tyr Arg Phe His  Ala Ile Asn 
    1040                 1045                 1050             


Gly Tyr  Val Met Asp Thr Leu  Pro Gly Leu Val Met  Ala Gln Asp 
    1055                 1060                 1065             


Gln Arg  Ile Arg Trp Tyr Leu  Leu Ser Met Gly Ser  Asn Glu Asn 
    1070                 1075                 1080             


Ile Gln  Ser Ile His Phe Ser  Gly His Val Phe Thr  Val Arg Lys 
    1085                 1090                 1095             


Lys Glu  Glu Tyr Lys Met Ala  Val Tyr Asn Leu Tyr  Pro Gly Val 
    1100                 1105                 1110             


Phe Glu  Thr Val Glu Met Leu  Pro Ser Arg Ala Gly  Ile Trp Arg 
    1115                 1120                 1125             


Val Glu  Cys Leu Ile Gly Glu  His Leu Gln Ala Gly  Met Ser Thr 
    1130                 1135                 1140             


Leu Phe  Leu Val Tyr Ser Lys  Lys Cys Gln Thr Pro  Leu Gly Met 
    1145                 1150                 1155             


Ala Ser  Gly His Ile Arg Asp  Phe Gln Ile Thr Ala  Ser Gly Gln 
    1160                 1165                 1170             


Tyr Gly  Gln Trp Ala Pro Lys  Leu Ala Arg Leu His  Tyr Ser Gly 
    1175                 1180                 1185             


Ser Ile  Asn Ala Trp Ser Thr  Lys Glu Pro Phe Ser  Trp Ile Lys 
    1190                 1195                 1200             


Val Asp  Leu Leu Ala Pro Met  Ile Ile His Gly Ile  Lys Thr Gln 
    1205                 1210                 1215             


Gly Ala  Arg Gln Lys Phe Ser  Ser Leu Tyr Ile Ser  Gln Phe Ile 
    1220                 1225                 1230             


Ile Met  Tyr Ser Leu Asp Gly  Lys Lys Trp Gln Thr  Tyr Arg Gly 
    1235                 1240                 1245             


Asn Ser  Thr Gly Thr Leu Met  Val Phe Phe Gly Asn  Val Asp Ser 
    1250                 1255                 1260             


Ser Gly  Ile Lys His Asn Ile  Phe Asn Pro Pro Ile  Ile Ala Arg 
    1265                 1270                 1275             


Tyr Ile  Arg Leu His Pro Thr  His Tyr Ser Ile Arg  Ser Thr Leu 
    1280                 1285                 1290             


Arg Met  Glu Leu Met Gly Cys  Asp Leu Asn Ser Cys  Ser Met Pro 
    1295                 1300                 1305             


Leu Gly  Met Glu Ser Lys Ala  Ile Ser Asp Ala Gln  Ile Thr Ala 
    1310                 1315                 1320             


Ser Ser  Tyr Phe Thr Asn Met  Phe Ala Thr Trp Ser  Pro Ser Lys 
    1325                 1330                 1335             


Ala Arg  Leu His Leu Gln Gly  Arg Ser Asn Ala Trp  Arg Pro Gln 
    1340                 1345                 1350             


Val Asn  Asn Pro Lys Glu Trp  Leu Gln Val Asp Phe  Gln Lys Thr 
    1355                 1360                 1365             


Met Lys  Val Thr Gly Val Thr  Thr Gln Gly Val Lys  Ser Leu Leu 
    1370                 1375                 1380             


Thr Ser  Met Tyr Val Lys Glu  Phe Leu Ile Ser Ser  Ser Gln Asp 
    1385                 1390                 1395             


Gly His  Gln Trp Thr Leu Phe  Phe Gln Asn Gly Lys  Val Lys Val 
    1400                 1405                 1410             


Phe Gln  Gly Asn Gln Asp Ser  Phe Thr Pro Val Val  Asn Ser Leu 
    1415                 1420                 1425             


Asp Pro  Pro Leu Leu Thr Arg  Tyr Leu Arg Ile His  Pro Gln Ser 
    1430                 1435                 1440             


Trp Val  His Gln Ile Ala Leu  Arg Met Glu Val Leu  Gly Cys Glu 
    1445                 1450                 1455             


Ala Gln  Asp Leu Tyr 
    1460             


<210>  43
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  43

Thr Asp Val Thr Phe 
1               5   


<210>  44
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  44

Ile Ala Leu Phe 
1               


<210>  45
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  45

Phe Phe Leu Ser 
1               


<210>  46
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  46

Phe Leu Ser Leu 
1               


<210>  47
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  47

Leu Ser Leu Phe 
1               


<210>  48
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  48

Ser Leu Phe Asn 
1               


<210>  49
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  49

Leu Phe Asn Phe 
1               


<210>  50
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  50

Phe Asn Phe Cys 
1               


<210>  51
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  51

Asn Phe Cys Ser 
1               


<210>  52
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  52

Phe Cys Ser Ser 
1               


<210>  53
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  53

Cys Ser Ser Ala 
1               


<210>  54
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  54

Ser Ser Ala Thr 
1               


<210>  55
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  55

Leu Ser Trp Asn 
1               


<210>  56
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  56

Trp Asn Tyr Met 
1               


<210>  57
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  57

Asn Tyr Met Gln 
1               


<210>  58
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  58

Asp Leu Leu Ser 
1               


<210>  59
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  59

Leu Leu Ser Val 
1               


<210>  60
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  60

Leu Ser Val Leu 
1               


<210>  61
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  61

Ser Val Leu His 
1               


<210>  62
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  62

Val Leu His Thr 
1               


<210>  63
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  63

Leu His Thr Asp 
1               


<210>  64
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  64

His Thr Asp Thr 
1               


<210>  65
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  65

Thr Asp Thr Arg 
1               


<210>  66
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  66

Thr Arg Phe Leu 
1               


<210>  67
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  67

Arg Phe Leu Pro 
1               


<210>  68
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  68

Phe Leu Pro Arg 
1               


<210>  69
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  69

Leu Pro Arg Met 
1               


<210>  70
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  70

Pro Arg Met Pro 
1               


<210>  71
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  71

Arg Met Pro Thr 
1               


<210>  72
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  72

Pro Thr Ser Phe 
1               


<210>  73
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  73

Thr Ser Phe Pro 
1               


<210>  74
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  74

Asn Thr Ser Ile 
1               


<210>  75
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  75

Thr Ser Ile Met 
1               


<210>  76
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  76

Ser Ile Met Tyr 
1               


<210>  77
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  77

Ile Met Tyr Lys 
1               


<210>  78
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  78

Met Tyr Lys Lys 
1               


<210>  79
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  79

Phe Val Glu Tyr 
1               


<210>  80
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  80

Val Glu Tyr Met 
1               


<210>  81
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  81

Glu Tyr Met Asp 
1               


<210>  82
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  82

Tyr Met Asp His 
1               


<210>  83
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  83

Met Asp His Leu 
1               


<210>  84
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  84

Asp His Leu Phe 
1               


<210>  85
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  85

Pro Thr Ile Trp 
1               


<210>  86
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  86

Thr Ile Trp Thr 
1               


<210>  87
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  87

Ile Trp Thr Glu 
1               


<210>  88
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  88

Trp Thr Glu Val 
1               


<210>  89
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  89

Thr Glu Val His 
1               


<210>  90
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  90

Glu Val His Asp 
1               


<210>  91
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  91

Val His Asp Thr 
1               


<210>  92
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  92

His Asp Thr Val 
1               


<210>  93
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  93

Phe Pro Gly Glu 
1               


<210>  94
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  94

Pro Gly Glu Ser 
1               


<210>  95
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  95

Gly Glu Ser His 
1               


<210>  96
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  96

Glu Ser His Thr 
1               


<210>  97
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  97

Leu Val Cys Lys 
1               


<210>  98
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  98

Val Cys Lys Glu 
1               


<210>  99
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  99

Cys Lys Glu Gly 
1               


<210>  100
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  100

Gly Ser Leu Ser 
1               


<210>  101
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  101

Ser Leu Ser Lys 
1               


<210>  102
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  102

Leu Ser Lys Glu 
1               


<210>  103
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  103

Ser Lys Glu Arg 
1               


<210>  104
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  104

Arg Thr Gln Met 
1               


<210>  105
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  105

Thr Gln Met Leu 
1               


<210>  106
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  106

Gln Met Leu His 
1               


<210>  107
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  107

Met Leu His Gln 
1               


<210>  108
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  108

Leu His Gln Phe 
1               


<210>  109
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  109

His Gln Phe Val 
1               


<210>  110
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  110

Gln Phe Val Leu 
1               


<210>  111
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  111

Lys Asp Ser Phe 
1               


<210>  112
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  112

Asp Ser Phe Thr 
1               


<210>  113
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  113

Ser Phe Thr Gln 
1               


<210>  114
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  114

Phe Thr Gln Ala 
1               


<210>  115
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  115

Thr Gln Ala Met 
1               


<210>  116
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  116

Gln Ala Met Asp 
1               


<210>  117
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  117

Ala Met Asp Ser 
1               


<210>  118
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  118

Met Asp Ser Ala 
1               


<210>  119
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  119

Asp Ser Ala Ser 
1               


<210>  120
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  120

Ser Ala Ser Thr 
1               


<210>  121
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  121

Ala Ser Thr Arg 
1               


<210>  122
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  122

Ser Thr Arg Ala 
1               


<210>  123
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  123

Thr Arg Ala Trp 
1               


<210>  124
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  124

Leu Leu Ile Asp 
1               


<210>  125
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  125

Leu Ile Asp Leu 
1               


<210>  126
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  126

Ile Asp Leu Gly 
1               


<210>  127
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  127

Ser Ser His Lys 
1               


<210>  128
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  128

Ser His Lys His 
1               


<210>  129
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  129

His Lys His Asp 
1               


<210>  130
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  130

Lys His Asp Gly 
1               


<210>  131
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  131

Glu Pro Gln Trp 
1               


<210>  132
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  132

Pro Gln Trp Gln 
1               


<210>  133
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  133

Gln Trp Gln Lys 
1               


<210>  134
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  134

Trp Gln Lys Lys 
1               


<210>  135
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  135

Gln Lys Lys Asn 
1               


<210>  136
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  136

Lys Lys Asn Asn 
1               


<210>  137
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  137

Asn Glu Glu Met 
1               


<210>  138
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  138

Glu Glu Met Glu 
1               


<210>  139
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  139

Glu Met Glu Asp 
1               


<210>  140
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  140

Met Glu Asp Tyr 
1               


<210>  141
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  141

Asp Asp Leu Asp 
1               


<210>  142
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  142

Asp Leu Asp Ser 
1               


<210>  143
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  143

Leu Asp Ser Glu 
1               


<210>  144
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  144

Glu Met Asp Met 
1               


<210>  145
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  145

Met Asp Met Phe 
1               


<210>  146
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  146

Asp Met Phe Thr 
1               


<210>  147
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  147

Met Phe Thr Leu 
1               


<210>  148
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  148

Phe Thr Leu Asp 
1               


<210>  149
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  149

Thr Leu Asp Asp 
1               


<210>  150
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  150

Leu Asp Asp Asp 
1               


<210>  151
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  151

Leu Ser Ala Leu 
1               


<210>  152
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  152

Ser Ala Leu Gln 
1               


<210>  153
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  153

Ala Leu Gln Ser 
1               


<210>  154
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  154

Leu Gln Ser Glu 
1               


<210>  155
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  155

Gln Ser Glu Gln 
1               


<210>  156
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  156

Ser Glu Gln Glu 
1               


<210>  157
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  157

Glu Gln Glu Ala 
1               


<210>  158
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  158

Gln Glu Ala Thr 
1               


<210>  159
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  159

Glu Ala Thr Asp 
1               


<210>  160
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  160

Ala Thr Asp Tyr 
1               


<210>  161
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  161

Thr Asp Tyr Asp 
1               


<210>  162
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  162

Tyr Asp Asp Ser 
1               


<210>  163
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  163

Asp Asp Ser Ile 
1               


<210>  164
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  164

Asp Ser Ile Thr 
1               


<210>  165
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  165

Ser Ile Thr Ile 
1               


<210>  166
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  166

Ile Thr Ile Glu 
1               


<210>  167
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  167

Thr Ile Glu Thr 
1               


<210>  168
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  168

Ile Glu Thr Asn 
1               


<210>  169
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  169

Glu Thr Asn Glu 
1               


<210>  170
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  170

Thr Asn Glu Asp 
1               


<210>  171
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  171

Asn Glu Asp Phe 
1               


<210>  172
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  172

Asp Ile Tyr Gly 
1               


<210>  173
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  173

Ile Tyr Gly Glu 
1               


<210>  174
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  174

Tyr Gly Glu Asp 
1               


<210>  175
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  175

Gly Glu Asp Ile 
1               


<210>  176
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  176

Glu Asp Ile Lys 
1               


<210>  177
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  177

Asp Ile Lys Gln 
1               


<210>  178
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  178

Ile Lys Gln Gly 
1               


<210>  179
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  179

Lys Gln Gly Pro 
1               


<210>  180
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  180

Gln Gly Pro Arg 
1               


<210>  181
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  181

Met Ser Thr Ser 
1               


<210>  182
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  182

Ser Thr Ser Pro 
1               


<210>  183
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  183

Thr Ser Pro His 
1               


<210>  184
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  184

Arg Asn Arg Asp 
1               


<210>  185
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  185

Asn Arg Asp Gln 
1               


<210>  186
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  186

Arg Asp Gln Ser 
1               


<210>  187
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  187

Asp Gln Ser Gly 
1               


<210>  188
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  188

Gln Ser Gly Asn 
1               


<210>  189
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  189

Ser Gly Asn Ala 
1               


<210>  190
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  190

Gly Asn Ala Pro 
1               


<210>  191
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  191

Asn Ala Pro Gln 
1               


<210>  192
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  192

Ala Pro Gln Phe 
1               


<210>  193
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  193

Gly Ser Phe Ser 
1               


<210>  194
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  194

Ser Phe Ser Gln 
1               


<210>  195
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  195

Phe Ser Gln Pro 
1               


<210>  196
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  196

Ser Gln Pro Leu 
1               


<210>  197
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  197

Ile Ser Tyr Lys 
1               


<210>  198
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  198

Ser Tyr Lys Glu 
1               


<210>  199
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  199

Tyr Lys Glu Asp 
1               


<210>  200
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  200

Lys Glu Asp Gln 
1               


<210>  201
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  201

Arg Gln Gly Glu 
1               


<210>  202
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  202

Gln Gly Glu Glu 
1               


<210>  203
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  203

Gly Glu Glu Pro 
1               


<210>  204
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  204

Glu Glu Pro Arg 
1               


<210>  205
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  205

Glu Pro Arg Arg 
1               


<210>  206
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  206

Pro Arg Arg Asn 
1               


<210>  207
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  207

Arg Arg Asn Phe 
1               


<210>  208
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  208

Arg Asn Phe Val 
1               


<210>  209
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  209

Glu Thr Lys Ile 
1               


<210>  210
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  210

Thr Lys Ile Tyr 
1               


<210>  211
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  211

Lys Ile Tyr Phe 
1               


<210>  212
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  212

Ile Tyr Phe Trp 
1               


<210>  213
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  213

Asp Leu Glu Arg 
1               


<210>  214
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  214

Leu Glu Arg Asp 
1               


<210>  215
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  215

Glu Arg Asp Met 
1               


<210>  216
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  216

Arg Asp Met His 
1               


<210>  217
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  217

Asp Met His Ser 
1               


<210>  218
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  218

Met His Ser Gly 
1               


<210>  219
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  219

Leu Ile Cys His 
1               


<210>  220
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  220

Ile Cys His Thr 
1               


<210>  221
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  221

Cys His Thr Asn 
1               


<210>  222
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  222

His Thr Asn Thr 
1               


<210>  223
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  223

Thr Asn Thr Leu 
1               


<210>  224
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  224

Thr Leu Asn Pro 
1               


<210>  225
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  225

Leu Asn Pro Ala 
1               


<210>  226
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  226

Asn Pro Ala His 
1               


<210>  227
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  227

Pro Ala His Gly 
1               


<210>  228
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  228

Arg Gln Val Ala 
1               


<210>  229
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  229

Gln Val Ala Val 
1               


<210>  230
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  230

Val Ala Val Gln 
1               


<210>  231
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  231

Ala Val Gln Glu 
1               


<210>  232
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  232

Arg Asn Cys Lys 
1               


<210>  233
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  233

Asn Cys Lys Thr 
1               


<210>  234
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  234

Cys Lys Thr Pro 
1               


<210>  235
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  235

Lys Thr Pro Cys 
1               


<210>  236
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  236

Thr Pro Cys Asn 
1               


<210>  237
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  237

Glu Asn Ile Gln 
1               


<210>  238
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  238

Asn Ile Gln Ser 
1               


<210>  239
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  239

Ile Gln Ser Ile 
1               


<210>  240
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  240

Gln Ser Ile His 
1               


<210>  241
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  241

Leu Pro Ser Arg 
1               


<210>  242
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  242

Pro Ser Arg Ala 
1               


<210>  243
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  243

Ser Arg Ala Gly 
1               


<210>  244
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  244

Arg Ala Gly Ile 
1               


<210>  245
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  245

Arg His Gln Arg 
1               


<210>  246
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  246

Ser Phe Ala Gln Asn Ser Arg Pro Pro Ser Ala Ser Ala Pro Lys Pro 
1               5                   10                  15      


Pro Val Leu Arg Arg His Gln Arg 
            20                  


<210>  247
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  247

Cys Leu Leu Gln 
1               


<210>  248
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  248

Leu Leu Gln Phe 
1               


<210>  249
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  249

Leu Gln Phe Ser 
1               


<210>  250
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  250

Gln Phe Ser Phe 
1               


<210>  251
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  251

Leu Leu Ser Glu 
1               


<210>  252
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  252

Leu Ser Glu Leu 
1               


<210>  253
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  253

Glu Leu His Val 
1               


<210>  254
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  254

Arg Val Pro Arg 
1               


<210>  255
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  255

Val Pro Arg Ser 
1               


<210>  256
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  256

Pro Thr Ile Arg 
1               


<210>  257
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  257

Thr Ile Arg Ala 
1               


<210>  258
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  258

Ile Arg Ala Glu 
1               


<210>  259
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  259

Asn Glu Glu Glu 
1               


<210>  260
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  260

Glu Glu Glu Asp 
1               


<210>  261
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  261

Cys Asp Arg Asn 
1               


<210>  262
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  262

Glu Asp Thr Tyr 
1               


<210>  263
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  263

Pro Thr Tyr Leu 
1               


<210>  264
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  264

Leu Ser Glu Asn 
1               


<210>  265
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  265

Ile Thr Leu Thr 
1               


<210>  266
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  266

Ser Ile Glu Thr 
1               


<210>  267
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  267

Ile Glu Thr Lys 
1               


<210>  268
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  268

Glu Thr Lys Arg 
1               


<210>  269
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  269

Thr Lys Arg Glu 
1               


<210>  270
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  270

Lys Arg Glu Asp 
1               


<210>  271
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  271

Arg Glu Asp Phe 
1               


<210>  272
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  272

Gln Lys Arg Thr 
1               


<210>  273
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  273

Val Glu Gln Leu 
1               


<210>  274
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  274

Glu Gly Leu Trp 
1               


<210>  275
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  275

Gly Met Ser Arg 
1               


<210>  276
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  276

Met Ser Arg Ser 
1               


<210>  277
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  ancestral

<400>  277

Ser Arg Ser Pro 
1               


