                         SEQUENCE LISTING

<110>  Salk Institute for Biologic Studies
 
<120>  COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED DIABETES AND 
       RELATED DISORDERS

<130>  365550.1013WO1(00025)

<140>  PCT/US2016/013004
<141>  2016-01-12

<150>  62/154,652
<151>  2015-04-29

<150>  62/110,349
<151>  2015-01-30

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      


Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          


Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              


Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  


Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala 
65                  70                  75                  80  


Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      


Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         


Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             


Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 


Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 


Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     


Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         


Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             


Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
    210                 215                 220                 


Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly 
225                 230                 235                 240 


Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr 
                245                 250                 255     


Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln 
            260                 265                 270         


Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg 
        275                 280                 285             


Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu 
    290                 295                 300                 


Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg 
305                 310                 315                 320 


Lys Asn Pro Ile Asp His His Ser Ile Tyr Cys Ile Ile Ala Val Cys 
                325                 330                 335     


Ser Val Phe Leu Met Leu Ile Asn Val Leu Val Ile Ile Leu Lys Met 
            340                 345                 350         


Phe Trp Ile Glu Ala Thr Leu Leu Trp Arg Asp Ile Ala Lys Pro Tyr 
        355                 360                 365             


Lys Thr Arg Asn Asp Gly Lys Leu Tyr Asp Ala Tyr Val Val Tyr Pro 
    370                 375                 380                 


Arg Asn Tyr Lys Ser Ser Thr Asp Gly Ala Ser Arg Val Glu His Phe 
385                 390                 395                 400 


Val His Gln Ile Leu Pro Asp Val Leu Glu Asn Lys Cys Gly Tyr Thr 
                405                 410                 415     


Leu Cys Ile Tyr Gly Arg Asp Met Leu Pro Gly Glu Asp Val Val Thr 
            420                 425                 430         


Ala Val Glu Thr Asn Ile Arg Lys Ser Arg Arg His Ile Phe Ile Leu 
        435                 440                 445             


Thr Pro Gln Ile Thr His Asn Lys Glu Phe Ala Tyr Glu Gln Glu Val 
    450                 455                 460                 


Ala Leu His Cys Ala Leu Ile Gln Asn Asp Ala Lys Val Ile Leu Ile 
465                 470                 475                 480 


Glu Met Glu Ala Leu Ser Glu Leu Asp Met Leu Gln Ala Glu Ala Leu 
                485                 490                 495     


Gln Asp Ser Leu Gln His Leu Met Lys Val Gln Gly Thr Ile Lys Trp 
            500                 505                 510         


Arg Glu Asp His Ile Ala Asn Lys Arg Ser Leu Asn Ser Lys Phe Trp 
        515                 520                 525             


Lys His Val Arg Tyr Gln Met Pro Val Pro Ser Lys Ile Pro Arg Lys 
    530                 535                 540                 


Ala Ser Ser Leu Thr Pro Leu Ala Ala Gln Lys Gln 
545                 550                 555     


